Momwe mungasinthire Metformin: ndibwino bwanji kuchokera ku analogues?

Metformin ndi mankhwala osokoneza bongo a gulu la biguanides a m'badwo wachitatu.

Wothandizira antidiabetic amapereka zoletsa za gluconeogeneis njira ndi ma elekitironi kayendedwe ka kupuma ma mitochondria. Mankhwalawa amathandizira kukhudzika kwa glycolysis, komwe kumayambitsa kuthamanga kwa shuga ndi maselo. Kuphatikiza apo, mankhwalawa amachepetsa mayamwidwe am'mimba mwa makoma a matumbo.

Ma pharmacokinetics ndi pharmacodynamics a mankhwalawa ndiwakuti samapangitsa kuchepa kwakukulu pamlingo wa shuga mthupi, popeza alibe mphamvu yolimbikitsira ma cell a pancreatic omwe amapanga insulin.

Chofunikira chachikulu pa mankhwalawa ndi metformin hydrochloride.

Pali mitundu ingapo ya Metformin yomwe imasiyana muyezo wa kuyera kwa mankhwala ndi kapangidwe kazinthu zothandizira. Komanso, mankhwalawa ali ndi mitundu yambiri ya analogi. Generics of Metformin amapangidwa ndi makampani osiyanasiyana azamankhwala ku Russia, Israel, Poland ndi Hungary.

Mankhwalawa ali ndi zotsutsana zambiri komanso zoyipa, pakuzindikiridwa komwe madokotala amalimbikitsa kuti njira yoyambirirayo isinthidwe ndi fanizo loyenerera.

Zotsatira zoyipa zikachitika, wodwala matenda ashuga ayenera kudziwa momwe angachotsere Metformin ndi zomwe ma Metformin amafanana, komanso momwe mankhwalawa amasiyana.

Kupezeka kwa kuchuluka kwa mankhwalawa omwe amasiyana mosiyanasiyana mayina, ndipo popeza kukhala kulumikizana kwa Metformin, kumapangitsa wodwalayo kuganiza za Metformin yemwe ali wabwino komanso momwe sangapangire zolakwika ndi kusankha kwa mankhwalawa

Kodi chinthu chogwira ntchito Metformin ndi chiani?

Wogwira mankhwala metformin (dzina ladziko lonse lapansi - pln) ndiye chida chachikulu pa mapiritsi osiyanasiyana, omwe nthawi zambiri amalembedwa kwa odwala omwe amapezeka ndi matenda osokoneza bongo. Awa ndi mankhwala a hypoglycemic ochokera ku gulu la Biguanides a m'badwo wachitatu.

Mankhwala a hypoglycemic amalepheretsa njira ya gluconeogeneis, kayendedwe ka ma elekitrodi aulere mu kupumitsa kwa mitochondria.

Metformin imapangitsa chidwi cha machitidwe a glycolysis, maselo amayamba kuyamwa magazi mwachangu komanso mokulira. Mankhwalawa amathandizira kuchepetsa kuyamwa kwa shuga kuchokera ku lumen yogaya chakudya m'magazi a m'magazi. Mankhwalawa samayambitsa kuchepa kwakukulu pamlingo wamafuta m'magazi am'magazi, chifukwa alibe mphamvu yothandizira pazomwe amapanga insulin.

Kapangidwe ka zomwe zimagwira thupi la munthu ndikuwonetsa zotsatirazi:

1. Amachepetsa kuchepa kwa glycogen kuchokera ku chiwalo monga chiwindi. Zotsatira zake, kuwonjezeka koyambira m'magazi a glucose amawonedwa.
2. Imachepetsa njira ya kaphatikizidwe ka shuga wama protein ndi lipids.
3. Moyenerera kumapangitsa kutsika kwa shuga mu chiwindi.
4. Zimathandizira kuchepetsa mawonekedwe a insulin kukaniza ndikukulitsa chidwi cha maselo ndi minyewa ku timadzi timeneti, timene timapangidwa ndi kapamba.
5. Mwabwino amachepetsa mayamwidwe m'matumbo.
6. Zimalimbikitsa kutembenuka kwa glucose kuti agwiritse ntchito m'mimba.
7. Kuchulukitsa lipids yamagazi. Kuphatikiza apo, nthawi yomweyo pali kuchepa kwa cholesterol yoyipa mthupi.
8. Imakakamiza minofu kuti itenge shuga wambiri.

Kukonzekera ndi metformin kumakhala ndi mwayi umodzi wosayerekezeka poyerekeza ndi mankhwala ena - sikuti kumabweretsa chitukuko cha hypoglycemia, ndiko kuti, kuchuluka kwa chakudya m'magazi sikutsikira pang'onopang'ono.

Malangizo ogwiritsira ntchito mankhwala aliwonse a Metformin akuwonetsa kuti sikuti kungokhala ndi shuga kungakhale chidziwitso chovomerezeka. Mapiritsi amatha kuthandizidwanso pazinthu zotere:

• ngati pali kuphwanya kwa kulolerana kwa glucose kapena mavuto a glycemia amapezeka pambuyo podzuka,
• ndikupanga insulin kukana komanso kuwonjezeka kwakukulu kwa kulemera (makamaka pamimba) ꓼ
• Gynecology imagwiritsa ntchito mankhwala a metformin kuchiza ovarian cleopolycystosisꓼ
• pa kuwonetsedwa kwa metabolic syndromeꓼ
• Monga prophylactic popewa kukalamba kwa thupi.

Chosakaniza chophatikizacho chimakhudza ubongo ndipo chimachepetsa chiopsezo chokhala ndi matenda a Alzheimer's.

Kodi mayina ogulitsa mankhwalawa ndi ati?

Mankhwala okhala ndi metformin m'mafakitala amaperekedwa mokwanira. Makampani amakono opanga mankhwala ndi opanga amapanga mitundu ingapo yamitundu mitundu. Itha kukhala mapiritsi kapena makapisozi.

Gulu la mankhwalawa limaphatikizapo mitundu yosiyanasiyana yamankhwala.

Mankhwala oyamba a Metformin Teva. Mapiritsi oterewa, akhoza kukhala ndi magalamu 0,5 mpaka 1.0 a yogwira ntchito. Kutengera ndi kudwala kwa matendawa, adotolo amakupangira mankhwala omwe amafunikira kuchuluka kwa metformin hydrochloride. Kupanga ndi kugwiritsa ntchito bwino mapiritsi ndi udindo wa wopanga Israeli. Metformin Teva ndi mankhwala okhala ndi hypoglycemic effect. Amasankhidwa kuti apange shuga wachiwiri. Kuphatikiza apo, kuwonjezera pamankhwala omwe amapezeka nthawi zonse, mapiritsi amatha kuperekedwa m'njira ngati metformin yotulutsidwa. Mtengo wa mankhwalawa umatengera kuchuluka kwa mankhwala omwe ali m'gulu la mapiritsi. Mtengo wapakati, kutengera mtundu wa chinthu chomwe chikugwiririka kapangidwe kachipangizo kamankhwala, chimasiyana kuchokera pa ma ruble a 77 mpaka 280.

Metformin Canon ndi woimira wa mankhwala achilendo ku Russia. Wopanga wake ndi Russian pharmacological bizinesi Canonfarm Production. Mapiritsi a kapisozi a mankhwalawa, 500, 850 kapena 1000 mg ya mankhwala othandizira atha kukhala. Mankhwala amagwira ntchito ngati hypoglycemic, komanso amathandizanso kuteteza kulemera kwakukulu, makamaka ndi mankhwala. Metformin Canon imakhazikitsidwa bwino pamsika wama pharmacological. Mtengo wake umakhala wotsika kwambiri ndipo umasiyana ndi ma ruble 89 mpaka 130, kutengera mlingo womwe ukufunika.

Metformin Zentiva ndi woyimira mtengo kwambiri wa gulu lotere la kuchepetsa shuga. Mtengo wa mankhwalawa ukhoza kukhala kuchokera ku ruble 118 mpaka 200. Wopangayo ndi kampani ya ku Slovak, yomwe imapatsa ogula mankhwala mankhwala otsatirawa - 0,5, 0,85 kapena 1 gramu ya zinthu zomwe zimagwira. Monga lamulo, Metformin Zentiva amalembedwa kuti achepetse kuchuluka kwa chakudya chamagazi m'magazi, komanso ngati pali insulin yolimbana ndi odwala omwe ali ndi zaka zopitilira khumi.

Metformin Richter ndi imodzi mwazofanizira za metformin yopangidwa ndi imodzi mwa makampani opanga awiriwo. Komwe kuli kampani yopanga zamankhwala ndi Russian Federation ndi Hungary. Kuphatikizika kwa mankhwalawa kumaphatikizapo 500 mpaka 1000 mg ya mankhwala othandizira. Limagwirira ntchito ya metformin umalimbana ndikuchotsa hyperglycemia ndi kuphatikiza kulemera kwakukulu.

Nthawi zambiri mankhwalawa amatchulidwa kuti alowe m'malo mwa mankhwalawo. Mtengo wa mankhwalawa umachokera ku ma ruble a 180 mpaka 235.

Momwe mungamwe mankhwalawo?

Mapiritsi okhala ndi Metformin hydrochloride nthawi zambiri amalembedwa zizindikiro zoyambirira za shuga zikawoneka.

Mlingo woyambirira wa mankhwalawa sayenera kupitirira 0,5 magalamu a mankhwala othandizira. Dokotala yemwe akupezekapo angakulimbikitseni kumwa mapiritsi pakudya kapena mutatha kudya, kutengera zosowa za wodwalayo. Kuchuluka kwa Mlingo wa mankhwalawa sikuyenera kupitilira kawiri kapena katatu patsiku. Pakangotha ​​sabata imodzi kapena iwiri kuchokera pomwe njira yochiritsira isanayambike, kuunikanso kwa Mlingo wokhazikitsidwa kumaloledwa mmwamba. Mlingo wambiri womwe ungatheke tsiku lililonse suyenera kupitirira magalamu awiri a chinthu chomwe chikugwira ntchito. Tiyenera kudziwa kuti ngati mugwiritsa ntchito mankhwalawa musanayambe kudya, ndiye kuti zochita za zomwe zimagwira zimatha kuchepa kwambiri. Nthawi zina, metformin imaphatikizidwa ndi jakisoni wa insulin. Chifukwa chake, kuchuluka kwa jakisoni kumakwaniritsidwa.

Ku Metformin, pharmacokinetics akuwonetsa kuti mankhwalawa, atayamwa pakamwa, amatha kuchuluka kwa plasma patatha pafupifupi maola awiri ndi theka.

Madzi a yogwira pophika amayima patatha maola asanu ndi limodzi atatha kugwiritsa ntchito mapiritsi.

Ma fanizo odziwika kwambiri a Metformin ndi Siofor ndi Glucofage.

Nchiyani chingalowe m'malo mwa mapiritsi a Metformin? Ndi mankhwala ati a pharmacy omwe amadziwika kwambiri pakati pa ogula?

Chimodzi mwazomwe amadziwika kwambiri ndi gulu la Biguanide ndi Siofor, yomwe imapangidwa piritsi. Chofunikira chachikulu cha mankhwalawo ndi metformin hydrochloride, ndipo silicon dioxide, povidone, magnesium stearate, ndi macrogol amagwiritsidwa ntchito ngati zida zothandizira.

Siofor 1000 yodwala matenda a shuga imagwiritsidwa ntchito kuchepetsa magazi. Nthawi yomweyo, kuchepa kwa zizindikiro kumachitika osati pambuyo pa chakudya chachikulu, komanso kumakupatsani mwayi kuti muchepetse maziko. Chofunikira chachikulu mu Siofor chimakupatsani mwayi wopanga ma insulin ndi kapamba, omwe amakhudza thupi bwino komanso samatulutsa chiwopsezo cha hypoglycemia.

Zizindikiro zazikulu zomwe Siofor amatchulidwa ndi matenda a shuga a mtundu wachiwiri, omwe samayendera limodzi ndi insulin. Mphamvu ya Siofor imawonekeranso bwino ndi kusakhazikika kwa mankhwala othandizira.

Gawo lomwe limagwira, lomwe ndi gawo la kapangidwe kameneka, limadziwonetsa kuti likuchepetsa kuyamwa kwa glucose m'matumbo ang'onoang'ono, limalepheretsa mapangidwe ake ndi maselo a chiwindi.

Glucophage ndi ofanana kapangidwe kake ndipo ndi chinthu chotengera metformin hydrochloride. Mpaka pano, mutha kugula mapiritsi azomwe mumakonda kapena nthawi yayitali. Kafukufuku wa zamankhwala adawonetsa kuti kumwa mapiritsi a glucophage kumakhala kovuta kuyambitsa ziwopsezo kuchokera ku ziwalo zam'mimba.

Nthawi yomweyo, mtengo wa Glucofage Long ndiwotsika kwambiri kuposa zomwe makompyuta ena amakonzekera.

Ndi chiani chinanso chomwe chitha kusintha mankhwala?

Momwe mungasinthire metformin? Funso ili lingabuke mwa munthu aliyense wodwala matenda ashuga. Masiku ano, pali mankhwala opitilira zana omwe ali amtundu wofanana kapena generic analogues.

Zitha kuphatikizira metformin hydrochloride, monga chinthu chachikulu, kapena kukhala imodzi mwazo (kuphatikiza mankhwala). Zoyambira zimaperekedwa ngati mitundu yotsika mtengo kapena yotsika mtengo ya mapiritsi. Kusiyana kwa mtengo kumadalira wopanga kapena mlingo wa mankhwalawo.

Mayina odziwika kwambiri a mankhwala ofanana:

Zomwe zili zoyenera kwa wodwalayo zitha kungosankhidwa ndi katswiri yemwe akuwongolera matenda ake.

Mwachitsanzo, Glformin ndi woimira kalasi yayikulu, yomwe imaphatikizapo metformin hydrochloride.Zofanana zokhudzana ndi momwe zimakhudzira thupi zimafotokozedwa ndikuti kapangidwe kake kamakhala ndi zinthu zomwezi. Glyformin amalimbikitsa kukondowanso kowonjezera kwa insulin chifukwa cha maselo a beta, komanso zimakhudza kugwiritsidwa ntchito kwazowonjezera kwa kuchuluka kwa shuga ndi minofu.

Ngati mutenga Glformin ndi mankhwala ena a hypoglycemic nthawi yomweyo, zotsatira zake pakuchepetsa misempha ya magazi kumawonjezeka.

Kodi pali kusiyana m'njira ndi chinthu chimodzi chogwira ntchito?

Nthawi zina mutha kupeza ndemanga za odwala kuti kugwiritsa ntchito ma Metformin sikubweretsa zotsatira zabwino. Ena amayamba kuwonetsa zochita zosiyanasiyana. Tisaiwale kuti lingaliro la kufunika kochotsa mankhwalawa liyenera kuchokera kwa dokotala, kutengera mtundu wa chitukuko cha matenda, komanso mikhalidwe ya wodwalayo. Ichi ndichifukwa chake sikuli bwino kufunafuna mosavomerezeka mankhwala omwe ali m'gulu la mankhwala ofanana ndi dokotala.

Kuphatikiza apo, zida zosiyanasiyana zamankhwala zingakhale ndi chinthu chimodzi chogwira ntchito, koma zimasiyana pakapangidwe kazida zamagetsi othandizira. Ndizowonjezera izi zomwe zingayambitse kuvulaza thupi ndikupanga zovuta.

Ndiye chifukwa chake, malingaliro a akatswiri amadzinamiza mpaka akuti mankhwala a analog amatha m'malo mwa mankhwala akuluakulu pokhapokha ngati lingaliro la adokotala likupita. Monga lamulo, mukamayamba kumwa mankhwala ena, kusapezeka kwa zotsatirapo zabwino kumachitika ngati malamulo olondola kapena a piritsi sakusungidwa ndipo ngati pakhale kuphwanya zakudya.

Mankhwala omwe angagwiritsidwe ntchito kwa odwala matenda ashuga afotokozeredwa ndi katswiri mu kanema munkhaniyi.

Mitundu yayikulu ya Metformin

Pali mitundu ingapo ya mankhwalawa. Onsewa ali ndi maziko ofanana a dzinalo ndipo amasiyana m'mawu oyambira okha kapena mawu ofunikira.

Kuphatikizidwa kwa mitundu yonse ya mankhwalawa kumaphatikizapo metformin hydrochloride monga gawo lalikulu, lodziwika ndi digiri ya kuyeretsa. Mlingo wa kuyeretsa kwazomwe zimagwira zimadalira matekinoloje omwe amagwiritsidwa ntchito ndi makampani opanga mankhwala popanga mankhwala

Kuphatikiza apo, mankhwalawa atha kukhala ndi kusiyana pakapangidwe ndi kuchuluka kwa zinthu zina zomwe zimagwira ntchito yothandizira.

Mitundu ikuluikulu ya mankhwalawa ndi mankhwala omwe amatchedwa Metformin ndi zina zotsatirazi m'dzina:

Mu mitundu yamankhwala awa, mankhwala otsatirawa amagwiritsidwa ntchito ngati zina zowonjezera:

1. Povidone K 90.
2. Wowuma chimanga.
3. Crospovidone.
4. Magnesium wakuba.
5. Talc.
6. Methaconic acid.
7. Methyl methacrylate kopolymer.
8. Macrogol 6000.
9. Titanium dioxide

Mankhwalawa amapangidwa ndi makampani osiyanasiyana, koma amakhudzana ndi mankhwala oyamba. Kukonzekera kumakhala ndi kusiyana pakapangidwe ndi kuchuluka kwa zosakaniza piritsi limodzi.

Momwe mungasinthire Metformin - ndi fanizo liti?

Mankhwala ambiri ali m'gulu la Biguanides, onsewa ndi ma fanizo kapena cholowa m'malo mwa Metformin. Mankhwalawa amatha kukhala ndi kusiyana kwakukulu pakati pa wina ndi mnzake muzochita zake komanso pazinthu zothandizira.

Mankhwalawa amaphatikizidwa ndikupezeka m'gulu limodzi, pharmacodynamics ndi pharmacokinetics. Makampani opanga mankhwala amapanga zonse zotsika mtengo komanso zotsika mtengo.

Pogwiritsa ntchito matenda a shuga panjira ya mankhwalawa, mankhwala osiyanasiyana amakhala ndi mavuto osiyanasiyana, atha kukhalanso ndi zotsutsana zosiyanasiyana komanso malire pazogwiritsa ntchito.Pachifukwa ichi, kusankha kwa mankhwala oyenera kuyenera kuchitika ndi asing'anga malinga ndi machitidwe a thupi la wodwalayo komanso zotsatira za mayeso.

Mpaka pano, ma fanizo otsika mtengo a Metformin apangidwa:

Ma fanizo odziwika kwambiri a mankhwala oyamba ndi awa:

Kuphatikiza pa mankhwalawa, mankhwalawa amapezekanso, momwe metformin imathandiziranso ngati othandizira. Mankhwalawa ndi:

• Dianormet
• Diaformin,
• Emnorm EP,
• Meglift,
• Methamine
• Metamine SR,
• Tefor
• Glycomet
• Glycomet SR
• Insulor,
• Mepharmil.

Kuphatikiza apo, makampani opanga mankhwala amapanga mitundu ingapo ya mankhwala omwe amasiyana mu kapangidwe ka mankhwala, koma ali ndi makina a pharmacological pa thupi lofanana ndi Metformin.

Mankhwala odziwika kwambiri m'gululi ndi awa:

1. Zothandiza zili ndi rosiglitazone ndi metformin.
2. Glibenclamide.
3. Maninil.
4. Ziphuphu.
5. Diabetes.
6. Gliclazide.
7. Glibomet.
8. Glucovans.
9. Dianorm.
10. Gluconorm.
11. Glybophor.
12. Galvus ndi ena ambiri.

Kuti musankhe molondola wothandizila wodwala matenda ashuga, muyenera kulumikizana ndi endocrinologist yemwe angadziwitse mitundu yoyenera ya mankhwala ndi mankhwala ochizira.

Siofor ndi Glucofage - mawonekedwe a mankhwala, mitundu ya kumasulidwa ndi kugwiritsa ntchito

Siofor ndi othandizira odwala matenda ashuga, mankhwala achi Germany, ndipo amapangidwira mankhwala a matenda ashuga a 2. Chofunikira chachikulu ndi metformin hydrochloride. Amapezeka mu mawonekedwe a mapiritsi omwe ali ndi Mlingo wa 500 ndi 1000 mg. Imagulitsidwa pamakatoni ama CD ndipo imapatsidwa malangizo atsatanetsatane kuti agwiritse ntchito.

Mankhwalawa ndi a gulu la Biguanides. Mankhwala amatha kuchepetsa shuga m'magazi a m'magazi, komanso amathandizanso kagayidwe ka lipid. Kugwiritsa ntchito mankhwalawa kumalimbikitsidwa pamaso pa matenda a shuga 2 omwe amayamba chifukwa cha kunenepa. Mankhwalawa amaletsedwa kutenga pakati pa nthawi yoyembekezera komanso yoyamwitsa.

Glucophage ndi dziko lopanga ku France. Amagwiritsidwa ntchito pochiza matenda a shuga a mtundu wachiwiri. Chogulitsacho chimapangidwa ngati mapiritsi okhala ndi Mlingo wa 500 ndi 1000 mg. Mapiritsiwo ali ndi chinthu chokhacho chothandiza - metformin hydrochloride.

Mankhwalawa ali ndi zotsutsana zosiyanasiyana, motero musanagwiritse ntchito, muyenera kufunsa ndi endocrinologist.

Gluconorm ndi Glibenclamide - kugwiritsa ntchito ndi kupanga mankhwala

Gluconorm ndi mankhwala ophatikiza, omwe ali ndi magawo awiri omwe amagwira ntchito - metformin hydrochloride ndi glibenclamide, yomwe imachokera ku sulfonylurea.

Kuphatikiza apo, kuphatikiza kwa mankhwalawa kumaphatikizapo, monga zowonjezera, chimanga wowuma, glycerol, silicon dioxide, magnesium stearate, talc, croscarmellose ndi sodium carboxymethyl wowuma, gelatin, diethyl phthalate ndi cellacephate.

Malondawa ali ngati mapiritsi. Mankhwala ali ndi anti-glycemic. Mukamagwiritsa ntchito, muyenera kusamala.

Kumbukirani kuti munthawi ya mankhwala ndi mankhwalawa, kukula kwa mavuto omwe amakhudza:

• kagayidwe kachakudya njira
• ntchito ya chiwindi ndi ziwalo zam'mimba,
• kugwira ntchito kwa magazi kupanga ziwalo ndi chapakati mantha dongosolo.

Zotsatira zoyipa zoterezi zimatha kutsagana ndi hypoglycemia, lactic acidosis, nseru, kusanza ndi kupweteka pamimba. Mankhwala amatengedwa nthawi imodzi ndi chakudya.

Glibenclamide ndi ya fanizo la Metformin malinga ndi mphamvu ya zamankhwala, komabe, chophatikizacho ndichoyimira gulu lina la mankhwala. Gawo lalikulu la Glibenclamide ndi gulu la dzina lomweli, lomwe limatanthawuza kuchokera ku sulfonylurea.

Glibenclamide imalimbikitsa kapangidwe ka insulin mthupi m'maselo a pancreatic beta. Kuikidwa kwa Glibenclamide ndikoyenera ngati kugwiritsa ntchito mankhwala osokoneza bongo sikupereka zotsatira zabwino. Mankhwala mogwirizana ndi malangizo ali ndi mndandanda wosiririka wa contraindication ogwiritsa ntchito ndi zotsatira zoyipa kuchokera pakugwiritsa ntchito.

Chifukwa chake, popanga mankhwala, munthu ayenera kuganizira za kukhalapo kwa contraindication komanso kukula kwa zovuta.

Saksagliptin, Satagliptin - fanizo la Metformin

Saxagliptin ndi othandizira odwala matenda ashuga, m'mapangidwe omwe mawonekedwe osadziwika a hydrochloride amaphatikizidwa ngati gawo limodzi. Mankhwala ali ndi mndandanda wocheperako wa contraindication kuti mugwiritse ntchito.

Kuphatikiza apo, iyenera kugwiritsidwa ntchito mosamala mu odwala okalamba komanso anthu omwe ali ndi impso ndi hepatic insuffidence.

Kusamala kowonjezeranso kofunikira pakugwiritsa ntchito chida ichi molumikizana ndi zotumphukira za sulfonylurea panthawi yochizira matenda a shuga 2.

Mukamagwiritsa ntchito mankhwalawa zotsatirazi zingachitike:

Mukagwiritsidwa ntchito molumikizana ndi Metformin, nasopharyngitis ndi mutu zimachitika.

Sitagliptin ndi choletsa kusankha kwambiri cha DPP-4. Mankhwalawa ali ndi kusiyana kosiyanasiyana kogwirizana ndi othandizira ena. Cholinga cha pakamwa. Machitidwe a siagliptin amasiyana ndi ma pharmacological amakhudzanso thupi la biguanides. Gawo lolimbikira, lotsekera DPP-4, limabweretsa kuwonjezeka kwa kuchuluka kwa ma insretin, insulinotropic glucose-wodalira ndi glucagon-peptide.

Kuchuluka kwa mankhwalawa kumabweretsa kuchepa kwa glucagon, komwe, motsutsana ndi kuwonjezeka kwa kapangidwe ka insulin, kumabweretsa kutsika kwa kuchuluka kwa shuga m'magazi a magazi.

Kodi metformin ndi chiyani

Metformin ndi m'gulu la mankhwala otchedwa biguanides. Metformin imachepetsa kuchuluka kwa shuga wopangidwa ndi chiwindi, potero kutsitsa shuga m'magazi. Mwa izi, itha kuthandizanso thupi kuyankha bwino ku insulini yake yomwe. Metformin nthawi zambiri imakhala mankhwala ochizira matenda a polycystic ndi matenda ashuga, chifukwa sangalepheretse shuga wochepa magazi poyerekeza ndi mankhwala ena.

Ngakhale kuti metformin ndiyothandiza, ilinso ndi zovuta zingapo zomwe zimaphatikizapo:

• kutsegula m'mimba
• bloating / kuchuluka kubwezerera
• kupweteka kwam'mimba
• kutsokomola
• kuchepa kwamtima
• kupweteka kwa minofu ndi kukokana
• kulawa kwazitsulo mkamwa
• kutopa

Komanso, akamwetsa, kupweteka pachifuwa kapena pachifuwa kumachitika, chomwe chimakhala chizindikiro chachikulu kuti tiletse mankhwalawo! Komanso, ngati muli ndi matenda a impso, ndiye kuti kugwiritsa ntchito metformin kumayeserera kwa inu ndipo muyenera kuyisintha ndi china chake. Kupanda kutero, pali chiopsezo chotenga lactic acidosis yovuta koma yoopsa.

Nthawi zonse funsani kwa dokotala wanu ngati muli ndi zovuta zilizonse kapena mukuda nkhawa ndi mankhwala omwe mukugwiritsa ntchito.

1. Zakudya zoyenera komanso masewera olimbitsa thupi

Njira yothandiza kwambiri pakuyang'anira PCOS ndikusintha moyenera pazakudya zanu ndi moyo wanu.Kutsatira kudya kwa PCOS, komanso kuchita masewera olimbitsa thupi pafupipafupi, kumathandizira kuchepa kwa magazi, kulimbikitsa kusamalira bwino minyewa komanso kuchuluka kwa insulin. Kudya moyenera, kosakonzedwa pang'ono, zakudya zathunthu komanso kuchita masewera olimbitsa thupi ndizovuta masiku ano, koma mphotho ndiyofunika!

Malangizo ofunikira pokonza zakudya zoyenera ku PCOS: yesani kudya kangapo patsiku m'magawo ang'onoang'ono tsiku lonse. Izi zikuthandizira kupewa kulumpha mwadzidzidzi mu insulin m'magazi, kuonetsetsa kuti ndi yosalala komanso yopanda malire.

Ndikofunikira kuti thupi la mkazi lizitha kudya mafuta ambiri tsiku lililonse. Ndi mafuta omwe amatenga nawo gawo pazomwe zimachitika mu mahomoni ogonana ndikuwongolera dongosolo lonse la amayi.

2. Yesani Ayurvedic Herb Jimnem Sylvester (Gymnema)

Gimnema sylvestre, yomwe nthawi zina imadziwika kuti "wowononga shuga," imasokoneza thupi kuti lizitha kumva kukoma. Chomera ndi njira imodzi yothanirana ndi metformin. Zimathandizira kukhala ndi shuga wabwinobwino wamagazi ndi kumva kwa insulin.

Kafukufuku wa 2001 omwe adafalitsidwa mu Diabetes in Control Newsletter adapeza kuti mankhwala owonjezera omwe amalimbitsa thupi amathandizira kusintha kwa shuga mu mtundu 2 odwala matenda ashuga.

Jimnyu Sylvester atha kuledzera mtundu wa tiyi, makapisozi ndi zotulutsa molingana ndi mlingo womwe ukulembedwera palemba la wopanga.

Mwachitsanzo, takusankhani njira zabwino kwambiri kuchokera ku iHerb.com:

Savsta, Gymnema, 60 Veggie Caps

Yankho Lachilengedwe, Gymnema, Mowa Waulere, 600 mg, 1 fl oz (30 ml)

3. Dziwani Zambiri za Chromium Picolinate

Chromium picolinate ndi mchere wofunikira womwe ungathandize kuchepetsa kulakalaka kwa shuga ndikuwongolera chidwi cha insulin - vuto kwa azimayi ambiri omwe ali ndi PCOS.

Phunziro la 2009 lofalitsidwa mu magazini ya "Matenda A shuga, Kunenepa kwambiri ndi Metabolism", Adawonetsa kuti kuwonjezera kwa chromium kumathandizira kufalitsa kwa insulin mu mbewa ndi shuga.

Ngakhale kuti pakufunika kufufuza zochulukirapo, kufufuza koyambirira kumakhala kolimbikitsa. Kuchuluka: 200-400 mcg tsiku lililonse.

Solgar, Chromium Picolinate, 500 mcg, 120 Veggie Caps

Tsopano Zakudya, Chromium Picolinate, 200 mcg, 250 Makapisozi

4. Onjezani Inositol

Kafukufuku yemwe adasindikizidwa mu 2014 mu magazine "Gynecological Endocrinology », ikuwonetsa kuti myo-inositol ndi D-chiro-inositol amathandizira kuteteza insulin mwa akazi omwe ali ndi PCOS. Miyezo ya insulin ikadzakhala yolondola, ntchito yamchiberekero, kuchuluka kwa dzira, ndi thanzi la msambo zimatha kuyenda bwino. Kuchuluka: 500 mg kawiri kapena kanayi pa tsiku.

Jarrow Formula, Inositol, 750 mg, 100 Veggie Caps

5. Dziwani zambiri za Berberine

Momwe mungasinthire metformin, ngati si Berber. Kafukufuku adasindikizidwa mu European Journal of Endocrinology mu 2012, zikuwonetsa kuti Berberine ali ndi maubwino ofanana a insulin-normalizing, ofanana ndi metformin pochiza PCOS, koma osakhala ndi zotsatirapo zoyipa! Kuphatikiza apo, Berberine anali wamkulu kuposa Metformin pakuchepetsa zina zowopsa, monga kuwonjezeka kwa chiuno komanso m'chiuno kupita m'chiuno. Berberine amapezeka mwachilengedwe m'zomera monga Coptis (Coptisapois), mphesa za Oregon (Berberis aquifolium) ndi Goldenseal (Hydrastis canadensis). Kwa nthawi yayitali amagwiritsidwa ntchito ngati mankhwala achi China monga mankhwala othandizira kupewa komanso kuchiza matenda ashuga.

Berberine wabwino kwambiri pa iHerb.com:

Zinthu Zachilengedwe, Berberine WellBetX, 500 mg, 60 Veggies

Solaray, Berberine Extract, Foramu Yotsogola, Makapu 60 a Veggie

PCOS ndivuto lomwe lingathane nawo!

Kuzindikira kwa PCOS kumawoneka ngati kosafunikira. Komabe, nthawi zambiri imatha kusinthidwa ndi zakudya komanso moyo. Metformin itha kupindulitsa azimayi ena omwe ali ndi PCOS yoletsa insulin. Koma sikuti azimayi onse omwe ali ndi vuto logontha omwe ali ndi PCOS ayenera kumwa. Funsani madokotala anu mafunso ndikuwona njira zina zachilengedwe ngati zingatheke.

Yambani ndi zakudya zoyenera. Phatikizaninso mafuta athanzi azakudya zanu. Idyani zipatso zambiri makamaka masamba ndi zitsamba.Yang'anani shuga yanu yamagazi kuti muwone momwe pulogalamu yanu yochira imayendera. Tsopano mukudziwa momwe mungasinthire metformin. Khalani ophunzira komanso adziwitsidwa zamomwe mungasankhire!

Kuchepetsa Ntchito

Kodi ndizotheka kumwa Metformin kuti muchepetse thupi, ngati shuga ndichabwinobwino? Kuwongolera uku pakukhudzana ndi mankhwala chifukwa cha kuthekera kwake kumenya nkhondo osati ma plaque m'mitsempha yamagazi, komanso ma deposits amafuta.

Kuchepetsa thupi mukamamwa mankhwala kumachitika chifukwa chotsatira:

• kuthamanga kwamafuta oxidation,
• kuchepa kwa kuchuluka kwa zomwe mwapeza
• kuchuluka kwa glucose chifukwa cha minofu.

Izi zimachotsanso kumverera kwanjala yosalekeza, zimathandizira kuti thupi lizikula msanga. Koma muyenera kutentha mafuta mukudya.

Kuti muchepetse kunenepa, muyenera kusiya:

Masewera olimbitsa thupi, monga masewera olimbitsa thupi olimbitsa thupi tsiku lililonse, amafunikanso. Ma regimen akumwa ayenera kuyang'aniridwa mosamala. Koma kumwa mowa ndikoletsedwa.

Tiyenera kukumbukira kuti kuchepa thupi kumangowonjezera mphamvu ya mankhwalawo. Ndipo adokotala okha ndi omwe angadziwe kufunika kwa Metformin kuti athane ndi kunenepa kwambiri.

Ntchito yoletsa kukalamba (anti-okalamba)

Metformin imagwiritsidwanso ntchito polepheretsa kusintha kokhudzana ndi zaka m'thupi.

Ngakhale mankhwalawa siwopanda chiyembekezo chaubwana wamuyaya, amakulolani:

• bwezeretsani kuchuluka kwa bongo ku mawu ofunikira,
• kuchepetsa chiopsezo cha neoplasms yoyipa,
• limbitsani mtima minofu.

Vuto lalikulu la chiwalo chokalamba ndi atherosulinosis, yomwe imasokoneza kugwira ntchito kwa mtima ndi mitsempha yamagazi. Ndiye amene amayambitsa imfa zambiri zomwe zimachitika asanakwane.

Zotsatira za cholesterol yomwe imatsogolera ku atherosulinosis imachitika chifukwa:

• kuphwanya kachitidwe koyenera ka kapamba,
• kulakwitsa kwa chitetezo chamthupi,
• mavuto a metabolic.

Cholinga chake ndikukhalanso ndi moyo womwe anthu okalamba amatsogolera, pomwe amakhala ndi chakudya chambiri komanso zopatsa mphamvu, ndipo nthawi zina zimawonjezera.

Izi zimabweretsa kukokomeza magazi m'mitsempha ndikupanga ma cholesterol amana. Mankhwalawa amathandizira kuchepetsa mafuta m'thupi, kusintha kayendedwe ka magazi ndi kusintha ntchito ya ziwalo zonse ndi machitidwe. Ndiye kodi Metformin ingatengedwe ngati palibe shuga? Ndizotheka, koma pokhapokha ngati pali contraindication.

Zoyipa pa Metformin ndi:

• acidosis (pachimake kapena chovuta),
• nthawi ya pakati, kudyetsa,
• Matendawa ndimankhwala
• chiwindi kapena vuto la mtima,
• myocardial infaration
• Zizindikiro za hypoxia mukamwa mankhwalawa.
• kuchepa kwa thupi ndi matenda opatsirana,
• matenda am'mimba thirakiti (zilonda),
• kuchita zolimbitsa thupi kwambiri.

Lemberani Metformin kuti muchepetse thupi komanso kuti musinthe thupi ndikufunika kukumbukira zotsatirapo zoyipa:

• chiopsezo chowonjezereka cha anorexia
• mseru, kusanza, kutsegula m'mimba kumachitika,
• nthawi zina kukoma kwazitsulo kumawonekera
• kuchepa magazi kumatha kuchitika
• pakuchepa kwa mavitamini a B, ndipo kukonzekera kowonjezereka kumafunikira,
• kugwiritsa ntchito kwambiri, hypoglycemia ingachitike,
• Momwe thupi limagwirira ntchito lingayambitse mavuto amtundu wa khungu.

Makanema okhudzana nawo

Makhalidwe a pharmacological ndi malangizo ogwiritsira ntchito mankhwala Metformin:

Njira yogwiritsira ntchito Metformin osati pochiza matenda ashuga siyachilendo. Kuyambitsa kudzipanga nokha ndikusankha mulingo woyenera panokha osakambirana ndi othandizira azaumoyo ndizowopsa zomwe sizingachitike. Ndipo ziribe kanthu kuti awongolere motani odwala, kumva kwa dokotala kuti achepetse kulemera / kukonzanso mothandizidwa ndi Metformin ndikofunikira.

Moni, owerenga okondedwa komanso obwera kumene ku bulogu yanga. Lero, nkhaniyi ikunena za kuchiza kwa “matenda otsekemera,” monga imodzi mwazinthu zofunika kwambiri pa matenda ashuga.Ndawona kale zitsanzo zokwanira za zolakwika, zomwe sizinapangitse kusintha ndikukhumudwitsa ena.

Metformin hydrochloride - mayendedwe ndi mayina a malonda a mankhwalawo
Metformin yapadziko lonse
Zokonzekera zomwe zimakhala ndi metformin (mayendedwe osokoneza bongo ndi mayina ogulitsa)
Malangizo ogwiritsira ntchito metformin
Njira zazikulu zoyeserera
Zizindikiro za Metformin
Contraindication
Zotsatira zoyipa ndi zotsatira zake
Mlingo ndi njira yoyendetsera metformin
Kuthandiza ndi mankhwala osokoneza bongo a metformin
Momwe mungasinthire metformin?
Chifukwa chiyani metformin siyothandiza?

Metformin hydrochloride - mayendedwe ndi mayina a malonda a mankhwalawo

Bizinesi yama pharmacological imawonedwa ngati imodzi yopindulitsa kwambiri ndipo kampani yokha yaulesi kwambiri siyipanga mankhwala omwe mankhwala ake ndi metformin.

Pakadali pano, mutha kupeza ma analogi ambiri omwe ali ndi mayina osiyanasiyana ogulitsa. Mwa iwo pali onse amtengo wokwera mtengo, pafupifupi wotchuka, ndipo osadziwika ndi aliyense, wotsika mtengo. Pansipa ndikuganiza kuti mudziwe mndandanda wamankhwala, koma choyamba tidzakumana ndi metformin yomwe.
kukhutira
Metformin yapadziko lonse

M'malo mwake, metformin ndi dzina ladziko lonse lapansi, kapena metformin hydrochloride. Metformin ndi m'gulu la Biguanides ndipo ndi woimira yekha. Mayina ena onse omwe amapezeka muchipatala ndi mayina amalonda amakampani osiyanasiyana omwe amapanga mankhwalawa.

Mukalandira kalata kuchokera kwa dokotala kuti mupeze mankhwala aulere ku pharmacy, dzinalo limalembedwa. Ndipo kampani yomwe ingakupatseni zimadalira kupezeka kwa mankhwala opangira mankhwala komanso kwa omwe akuwayang'anira apamwamba omwe amasayina chilolezo chogulitsa ichi kapena mankhwalawo. Ndanena kale m'nkhani yanga "Momwe mungachiritsire matenda ashuga a 2?", Chifukwa chake ndimalimbikitsa kuti ndiwerenge kaye.

Tiyerekeze kuti akuluakulu aboma asayina mgwirizano ndi Akrikhin, ndiye kuti mankhwalawo amangokhala ndi glyformin ndipo osagwiritsa ntchito glucophage kapena siofor. Chifukwa chake, musadabwe ndipo musalumbirire kwa madokotala kuti sakupatsani zomwe mukufuna. Ndi kuti sizimadalira iwo, ndipo izi sizoyenera kwa madokotala. Iwo alemba dzina generic mu Chinsinsi. Malamulo amenewo.

Mndandanda wa mankhwala a metformin
kukhutira
Zokonzekera zomwe zimakhala ndi metformin (mayendedwe osokoneza bongo ndi mayina ogulitsa)

Mankhwala aliwonse asanagulitsidwe, nthawi yambiri imadutsa, kwinakwake kuyambira zaka 10. Poyamba, kampani imodzi imakhudzidwa ndikukula ndikupanga mankhwala. Mankhwala oyamba omwe adatulutsidwa ndi kampaniyi ndi achikale. Ndiye kuti, kampani yomwe idakhazikitsa mankhwala omwe adayambitsa ndikuyipanga yoyamba, kenako ndikugulitsa patentyi yopanga mankhwalawo kumakampani ena. Mankhwala otulutsidwa ndi makampani ena azitchedwa mageneral.

Mankhwala oyamba azikhala okwera mtengo kuposa a generic, koma malinga ndi mtundu wake amakhalanso abwino, chifukwa adayesedwa muzomwe amaphatikizidwa, kuphatikiza ojambula mapiritsi kapena mapiritsi. Ndipo makampani opanga ma generic ali ndi ufulu wogwiritsa ntchito zinthu zina zothandiza komanso zothandiza, koma samayang'ananso ntchito yawo, chifukwa chake magwiridwewo akhoza kukhala otsika.

Mankhwala oyamba a metformin ndi GLUCOFAGE, (France)

Pali mitundu yambiri ya zamagetsi, ndipo ndikuwonetsa otchuka kwambiri:

Siofor, (Germany)
Forin Pliva, (Croatia)
Bagomet, (Argentina)
Gliformin, (Russia)
Metfogamma, (Germany)
Novoformin, (Russia)
Foretin, (Russia)
Metformin, (Serbia)
Metformin Richter, (Russia)
Metformin-Teva, (Israel)

Kuphatikiza pa izi, pali zokonzekera zambiri zomwe opanga aku India ndi Chitchaina, omwe amakhala otsika mtengo kwambiri poyerekeza ndi omwe adawonetsedwa, komanso akutali kwambiri ndi iwo malinga ndi magwiridwe antchito.

Palinso mankhwala omwe amakhala ndi nthawi yayitali, mwachitsanzo, glucophage yomweyo.Komanso metformin ikhoza kukhala gawo lokonzekera, kuphatikizapo glucovans, gluconorm, glybomet, Janumet, galvus anakumana, amaryl M ndi ena. Koma zambiri za iwo munkhani zotsatirazi, chifukwa chake ndikukulangizani kuti mulembetse pazosintha za blog kuti musaphonye.

Ngati mungapeze metformin yaulere, pamaphikidwe okondera, ndiye kuti simuyenera kusankha. Ndipo aliyense amene adzagula ndi ndalama yake, amatha kusankha mankhwala oyenera kwambiri pamtengo ndi mtengo.

Yandex.Direct
Mafuta kuchokera ku caxapa m'mwazi!
Vuto la caxapa la magazi lithetsedwa m'masiku 15 - izi ndiye zotulukapo!
ankarred.ru
Chithandizo cha matenda a shuga!
Chithandizo chothandiza cha matenda a shuga ku MedOnGroup. Otsogolera endocrinologists. Ndiyimbireni!
medongroup-krsk.ru Adilesi ndi nambala yafoni Krasnoyarsk
Pali zotsutsana. Lankhulani ndi dokotala.
kukhutira
Malangizo ogwiritsira ntchito metformin

Metformin ili ndi zotumphukira za hypoglycemic, zomwe zikutanthauza kuti sizilimbikitsa kubisirana kwa insulin ndi kapamba. Mankhwalawa ali ndi zotulukapo zambiri ndipo ndilembera zofunikira kwambiri, ndipo pazithunzi pansipa mutha kuwona zonse (dinani kuti mukulitse).

Kutsika kwa glycogen kumasuka, motero kumachepetsa kukula kwa shuga m'magazi
amalepheretsa kaphatikizidwe ka shuga kuchokera m'mapuloteni ndi mafuta
kumapangitsa kutsika kwa shuga mu chiwindi
zimawonjezera chidwi cha zotumphukira zolandilira ku insulin, potero kuchepetsa insulin
amachepetsa kuyamwa kwamatumbo
kuchuluka kutembenuka kwa glucose kuti agwirizane m'mimba
imakhala ndi phindu pa lipids yamagazi, imachulukitsa kuchuluka kwa ma lipoproteins (HDL), imachepetsa cholesterol yathunthu, triglycerides ndi lowensens lipoproteins (LDL)
kuchuluka kwa mayendedwe a glucose kudzera mu nembanemba kulowa mu minofu, i.e., kumathandizira kutulutsa kwa glucose

Limagwirira zake ntchito mankhwala metformin

Popeza metformin ilibe mphamvu yokhudza kapamba, ilibe zotsatira zoyipa monga hypoglycemia (kuchepa kwambiri kwa shuga m'magazi), koma zina pambuyo pake.
kukhutira
Zizindikiro za Metformin

Mankhwala a Metformin si mankhwala antidiabetes okha. Mankhwalawa angagwiritsidwe ntchito:

Ndi kulolerana kwa glucose komanso kusokoneza shuga. Ndinalemba kale za izi mu nkhani yanga "Zizindikiro ndi Zizindikiro za matenda a shuga", kuti mutha kudzidziwa nokha.
Mankhwalawa kunenepa kwambiri, komwe kumayendetsedwa ndi insulin.
Mankhwalawa cleopolycystic ovary (PCOS) mu gynecology.
Ndi metabolic syndrome.
Pofuna kupewa kukalamba.
M'masewera.

Monga mukuwonera, metformin ili ndi mapulogalamu ambiri, ndipo ndilankhula zambiri za izi pazinthu zanga zamtsogolo. Posachedwa, pali chidziwitso chakuti mankhwalawa amaloledwa kwa ana azaka 10 kuti athandizidwe ku matenda a shuga mellitus MODY ndi kunenepa kwambiri. Mukamamwa metformin, ndikofunikira kuti musamwe mowa, chifukwa chomwe ndanena pamwambapa.
kukhutira
Contraindication

Mankhwalawa ali otsutsana pazochitika zotsatirazi:

Mimba komanso kuyamwa
opaleshoni yayikulu komanso kuvulala
vuto la chiwindi
ana ochepera zaka 10
Zakudya zama kalori ochepa (osakwana 1000 kcal patsiku), popeza pali acidization ya thupi, i.e, metabolic acidosis imayamba
Kulephera kwa impso (mulingo wa creatinine ndi wamkulu kuposa 0.132 mmol / l mwa amuna ndi 0.123 mmol / l mwa akazi)
m'mbuyomu lactic acidosis
kupezeka kwa zinthu zomwe zikuyambitsa mkaka wa m'mawere

Contraindative potenga metformin

Zinthu zomwe zingapangitse kuti lactic acid iwonjezere komanso kuchulukitsa kwa lactic acidosis:

Kuwonongeka kwa impso, komwe kumalepheretsa kuchotsa asidiyu m'thupi
mankhwala oledzera osakhazikika komanso poyizoni wa ethanol
matenda osachiritsika komanso opweteka kwambiri omwe amachititsa kuti minofu ipume (kupuma komanso kulephera kwa mtima, kulowetsedwa kwam'mnyewa wam'mimba, matenda am'mimba a pulmonary)
matenda ashuga ketoacidosis
matenda opatsirana pachimake omwe amapezeka ndi kusowa kwamadzi (kusanza, kutsegula m'mimba, kutentha thupi)

Zikatero, ndikofunikira kuletsa mankhwalawo, mwina kwakanthawi, kufikira homeostasis ya thupi ibwezeretsedwa. Ndikulemba za mawonetseredwe a lactic acidosis mu gawo la bongo.
kukhutira
Zotsatira zoyipa ndi zotsatira zake

Kuphatikiza pazabwino, kukonzekera kulikonse kopangidwa kumakhala ndi zotsatira zoyipa. Metformin sichoncho. Zotsatira zake zoyipa kwambiri ndi kugaya chakudya m'mimba. Ambiri mwa anthu omwe amatenga metformin amadandaula:

Kutsegula m'mimba
ukufalikira
nseru
masanzi
kukoma kwakasokonekera (kulawa kwazitsulo mkamwa)
kuchepa kwamtima

Monga lamulo, Zizindikiro zonsezi zimachitika kumayambiriro kwenikweni kwa chithandizo chamankhwala ndipo zimatha pambuyo pa milungu iwiri yoyendetsa. Zonsezi zimagwirizanitsidwa ndi kutsekeka kwa mayamwidwe am'matumbo, zomwe zimapangitsa kuti pakhale mpweya wambiri wopangidwa ndi mpweya woipa, womwe umayambitsa kutsekula m'mimba ndikutulutsa magazi mukamamwa metformin, ndipo patatha milungu ingapo thupi limakhala lovuta.

Zotsatira zoyipa za metformin

Ndichitenji ngati matumbo oyipa ndikudwala m'matumbo nditatulutsa metformin?

Chokhacho chomwe chingathandize ndikuchepetsa / kusiya kwa mankhwalawo kapena kudya ndi chakudya. Ngati izi sizithandiza ndipo zizindikilo sizikutha, ndiye kuti muyenera kusiyiratu mankhwalawa. Mutha kuyesanso kusintha mankhwalawo kukhala mankhwala kuchokera ku kampani ina. Poyerekeza ndi ndemanga, Glucophage satha kuyambitsa zizindikiro zosasangalatsa ngati izi.

Zoyipa kuti metformin ndizosowa, zomwe zimafunikanso kuchoka kwa mankhwalawo. Atha kukhala otupa, kapena erythema, kapena kuyabwa pakhungu. Musaiwale za lactic acidosis, yomwe ndalankhula zambiri zapamwamba.
kukhutira
Mlingo ndi njira yoyendetsera metformin

Monga lamulo, mankhwalawa amaperekedwa kale pazizindikiro zoyambirira za matenda osokoneza bongo ndipo izi zimapangitsa kuti asankhidwa, chifukwa mankhwalawo amalembedwa pa nthawi yake, ndipo izi zikuchitika kale 50%. Kuti muyambe, ndikukuwuzani mtundu wa metformin hydrochloride wopangidwa. Masiku ano, pali mitundu iwiri ya mankhwala omwe amasiyana pakanthawi kachitidwe: fomu yowonjezera ndi mawonekedwe abwinobwino.

Mitundu yonseyi imapezeka pamapiritsi, koma imasiyana.

Metformin yachilendo imapezeka mu Mlingo wa 1000, 850 ndi 500 mg.
Metformin yayitali imapezeka mu Mlingo wa 750 ndi 500 mg

Kuphatikiza mankhwala, metformin ikhoza kukhala mu mlingo wa 400 mg. Mwachitsanzo, mu glibomet.

Mlingo ndi njira yoyendetsera metformin

Mlingo woyambirira wa mankhwalawa ndi 500 mg kokha patsiku. Mankhwala amatengedwa mosamalitsa pambuyo kapena pakudya katatu patsiku. M'tsogolomu, pakatha milungu iwiri, ndizotheka kuwonjezera kuchuluka kwa mankhwalawa malinga ndi kuchuluka kwa shuga. Mlingo wapamwamba wa metformin patsiku ndi 2000 mg.

Ngati mumwa mankhwalawa musanadye, ndiye kuti mphamvu ya metformin imatsika kwambiri. Kumbukirani kuti mtundu uwu wa hypoglycemic unapangidwa kuti usinthe shuga, osasala kudya. Muyenera kukumbukiranso kuti popanda kuchepetsa zakudya zam'mimba, mphamvu ya mankhwalawa ndiyotsika kwambiri. Chifukwa chake muyenera kudya mukamamwa metformin molingana ndi mfundo zapakati pazakudya za shuga ndi kunenepa kwambiri.

Metformin ikhoza kuphatikizidwa ndi mankhwala ena ochepetsa shuga ndi insulin kuti mukwaniritse zotsatira zabwino kwambiri. Kuti muwone momwe mankhwalawa amathandizira, musathamangire ndipo nthawi yomweyo muyembekezere kuchepa kwamisempha. Muyenera kuyembekezera kwa masabata 1-2 mpaka mankhwalawo atakula kwambiri.

Pambuyo pake, tikulimbikitsidwa kuwunika kuchuluka kwa shuga m'magazi (m'mawa mpaka m'mawa) pogwiritsa ntchito glucometer (mwachitsanzo, Contour TC), komanso musanadye chakudya musanakagone. Koma muyenera kuwonetsetsa kuti nthawi yodyera isanathe maola 4-5. Ngati phindu la shuga la magazi silikufikiridwa munthawi imeneyi, ndiye kuti mutha kukulitsa mlingo, koma osapitirira pazovomerezeka.

Kodi ndingatenge metformin mpaka liti?

M'malo mwake, palibe yankho lomveka bwino la funso ili. Kutalika kwa ntchito kumadalira zolinga ndi zisonyezo poika metformin. Ngati zolinga za kanthawi kochepa zikwaniritsidwa, mwachitsanzo, kuchepa thupi, ndiye kuti metformin imathetsedwa mukangokwaniritsa. Ndi matenda a shuga, kagayidwe kazakudya umachepa kwambiri ndipo n`zotheka kuti mankhwalawa amayenera kuperekedwa kwa nthawi yayitali. Mulimonsemo, muyenera kusankha funso lokhudza kumwa mankhwala ndi dokotala.

Kuthandiza ndi mankhwala osokoneza bongo a metformin

Ndi mankhwala osokoneza bongo a metformin, hypoglycemia sizichitika, koma lactic acidosis kapena lactic acidosis imayamba. Izi ndizovuta kwambiri zomwe zitha kutha. Itha kuchitika ndikusakanikirana kwa zinthu zomwe zimatsogolera ku hypoxia komanso kugwiritsa ntchito metformin. Pamwambapa, ndinakuwuzani kuti izi zitha bwanji.

Zizindikiro za lactic acidosis ndi:

Kusanza ndi kusanza
kutsegula m'mimba
kupweteka kwambiri pamimba
kutsitsa kutentha kwa thupi
kupweteka kwa minofu
kupumira msanga
chizungulire
kulephera kudziwa

Munthu akapanda kuthandizidwa, nthawi yomweyo amayamba kugwa, kenako kufa.

Kodi thandizo ndi lactic acidosis ndi chiyani? Choyamba, kuthetsedwa kwa metformin komanso kugonekedwa kuchipatala mwachangu. M'mbuyomu, izi zimachitika ndi kulowetsedwa kwa sodium bicarbonate (koloko), koma chithandizo choterechi ndi chowopsa kuposa chabwino, chifukwa chake chidasiyidwa kapena kuchitidwa mwanjira zina.
kukhutira
Momwe mungasinthire metformin?

Pali nthawi zina pomwe mankhwalawo sioyenera kapena pali zotsutsana pazolinga zake. Momwe mungachitire ndi zomwe zingalowe m'malo mwa metformin? Ngati izi ndizosagwirizana kwambiri ndi mapiritsi, ndiye kuti mutha kuyesa kusintha kuti ikhale mankhwala a kampani ina, koma kuti mulinso ndi metformin, ndiye kuti, mwa kuyankhula kwina, sinthani ndi analogue.

Koma pakakhala chosokoneza chilichonse, kusinthanitsa ma analogue sikungathetse vutoli, chifukwa kumakhala ndi zotsutsana zomwezo. Pankhaniyi, metformin ikhoza kulowa m'malo mwa mankhwalawa, omwe adzakhala ndi machitidwe ofanana:

DPP-4 inhibitor (Januvia, galvus, onglise, trazenta)
fanizo la GLP-1 (byeta ndi victosa)
thiazolidinediones (avandium and actos)

Koma kusintha mankhwala ndikofunikira moyang'aniridwa ndi adokotala.
kukhutira
Chifukwa chiyani metformin siyothandiza?

Nthawi zina odwala amadandaula kuti mankhwalawa sawathandiza, ndiye kuti, sagwirizana ndi ntchito yake yayikulu - yotulutsa shuga. Izi zitha kuchitika pazifukwa zingapo. Pansipa ndalemba zifukwa zomwe metformin singathandizire.

Metformin sinatchulidwepo chizindikiro
Osakwanira mlingo
Chithandizo Cha Mankhwala
Kulephera kudya mukamamwa metformin
Kuchulukana kwamunthu payekha

Nthawi zina zimakhala zokwanira kuti musankhe molakwika komanso kuchepetsa kutsika kwa shuga sikungakuthandizeni kudikirira.

Ndi chisangalalo ndi chisamaliro, endocrinologist Dilara Lebedeva

Metformin ndi mankhwala ofunikira kwa anthu odwala matenda ashuga. Metformin Richter, omwe amawonetsa momwe amagwiritsidwira ntchito omwe ali oyenera odwala ambiri omwe ali ndi matenda ashuga, amathandiza kuchepetsa ndikukhalabe ndi kagayidwe kazomwe zimapangitsa kuti moyo ukhale wabwino, monga zikuwonetsedwa ndi kuwunika kokwanira kwa odwala.

Pharmacodynamics ndi pharmacokinetics

"Metformin" imalepheretsa gluconeogeneis m'chiwindi ndipo imakhala cholepheretsa kulowa kwa glucose kuchokera m'matumbo kulowa muchiwalo ichi.Poterepa, kuwonjezereka kwa kufalikira kwa glucose kumachitika komanso kumva mphamvu ya chiwindi kumapangitsa insulin kuwonjezeka. Njira izi siziphatikizidwa ndi machitidwe a hypoglycemic; mankhwalawa samakhudzana ndikupanga insulin ndi maselo a beta a kapamba, mosiyana ndi mankhwala ena a Metformin.

Zizindikiro zogwiritsidwa ntchito pakuchepetsa thupi zimawonekera chifukwa cha luso la mankhwalawo kukhazikika kapena kuchepetsa kwambiri kulemera kwa thupi la wodwalayo.

Mutatenga Metformin, zinthu zomwe zimayamba kugwira ntchito zimayamba kutuluka m'mimba, ndipo mphamvu ya mankhwalawa imayamba pambuyo pa maola 2-2,5. Chizindikiro cha mankhwalawa ndicho pafupifupi kwathunthu osagwirizana ndi mapuloteni a plasma.

"Metformin" imatha kudziunjikira impso ndi chiwindi, tiziwalo tating'ono, minofu minofu. Imafufutidwa pafupifupi kwathunthu ndi impso pambuyo pa maola 9-12 pambuyo pa kuwongolera. Ngati vuto la impso la wodwalayo lili ndi vuto, mankhwalawo amatha kudzikundana kwa nthawi yayitali.

Zizindikiro ndi contraindication

Zowonetsa kugwiritsa ntchito Metformin ndi izi:

• Type 2 shuga mellitus, akudutsa popanda chizolowezi cha ketoacidosis, chofunikira kwambiri kwa odwala matenda ashuga onenepa kwambiri.
• Kuphatikiza ndi insulin mtundu 2 shuga, onenepa kwambiri, kenako kutsata insulin.

Ngakhale kugwiritsidwa ntchito kwambiri kwa mankhwalawa, pali zotsutsana pakugwiritsira ntchito Metformin:

• Ketoacidosis mu shuga, ambiri boma kapena chikomokere.
• Kuphwanya kwaonekera kwa impso.
• Matenda owopsa omwe amatsogolera kuonekera kwa kupezeka kwa impso - matenda, kuchepa magazi m'mimba kwambiri kapena kusanza, kutentha thupi, matenda a kupuma, hypoxia.
• Matenda owopsa komanso osatha omwe amatsogolera minofu ya hypoxia - kulephera kwa mtima kapena kupuma, kulowetsedwa kwapakhungu.
• Pambuyo pochita opaleshoni yolemekezeka, pambuyo pake insulin imayikidwa.
• Kuchepa kwa chiwindi.
• Pachimake ethanol poyizoni, uchidakwa wosakhalitsa.
• Mimba
• Kuyamwitsa.
• Kusalolera payekha.

Mlingo wa mankhwala

Mlingo wa "Metformin" umatsimikizika potengera zomwe zili m'magazi ndipo amatsimikiziridwa ndi dokotala payekha kwa wodwala aliyense. Nthawi zambiri, mlingo woyambira umachokera ku 0,5 mpaka 1 g / tsiku. (Mapiritsi 1-2), kenako, potengera kuchuluka kwa glucose, atatha masiku 10-15 akuwongolera, kuwonjezereka kwapang'onopang'ono kwa Mlingo ndikotheka.

Mlingo wokonza Metformin ndi 1.5-2.0 g / tsiku. (Mapiritsi 3-4), ndipo muyeso waukulu ndi 3.0 g / tsiku. kapena mapiritsi 6. Kwa odwala omwe ali ndi zaka zapamwamba, mlingo waukulu kwambiri sioposa 1.0 g / tsiku. (Mapiritsi 2).

Zizindikiro zogwiritsidwa ntchito ndi Metformin komanso kuwunika kwa wodwala zikuonetsa kuti mankhwalawa amayenera kumwedwa panthawi ya chakudya kapena itatha, atatsukidwa ndi madzi osafunikira. Mlingo wa tsiku ndi tsiku umalimbikitsidwa kuti ukhale wogawika pakati Mlingo wa 2-3 masana.

Zochita Zambiri

Mankhwala osokoneza bongo amatha kubweretsa kukula kwa lactic acidosis.

Lactic acidosis imadziwika ndi zizindikiro zotsatirazi:

• Chizungulire, limodzi ndi mseru komanso kusanza.
• Kutsegula m'mimba
• Kuchepetsa kwambiri kutentha kwa thupi.
• Kuchuluka kupuma.
• Kupweteka kwambiri m'matumbo, m'mimba.
• Kuyiwala chikumbumtima ndi kuyambanso kugona.

Ngati zizindikiro zosachepera za lactic acidosis zikuwoneka, muyenera kusiya kumwa mankhwalawo "Metformin", kuchitapo kanthu kuchipatala.

Njira yothandiza kwambiri yochizira lactic acidosis ndi hemodialysis, ndipo kuthandizira kwa zizindikiro zina kumathandizanso.

Kuchita ndi mankhwala ena

Mankhwala "Metformin", zomwe zikugwiritsidwa ntchito kuphatikiza pamodzi ndi mankhwala ena munthawi yomweyo, sangathe kugwiritsidwa ntchito limodzi ndi dinazole chifukwa cha vuto la hyperglycemic.Ngati mukufunika kuthandizidwa ndi dinazole, muyenera kusintha mlingo wa Metformin, womwe uyenera kuchitika ndi dokotala.

Kulandila kwa "Metformin" kuyenera kuyimitsidwa kwathunthu kapena mlingo wake wophatikizidwa ndi mankhwala otsatirawa:

• Chlorpromazine.
• Mankhwala a antipsychotic.
• Kulera kwamlomo, mahomoni a chithokomiro, thiazide ndi loop diuretics.
• "Epinephrine."
• "Cimetidine."

Komanso, mukamagwiritsa ntchito Metformin, ndikofunikira kuti musiye kumwa mowa mopanda kutero, kuweruza ndi ndemanga za odwala, njira yothandizidwa imachepetsedwa kwambiri.

"Metformin": amawunika akamagwiritsa ntchito kuwonda

Zotsatira zakuchiritsira sizingokhala m'dera logwiritsa ntchito kukonzekera kwa Metformin. Zizindikiro zogwiritsira ntchito, ndemanga zikuwonetsa kuthekera monga:

• Kuchepetsa shuga.
• Kuchepetsa kupangika kwa insulin, zomwe zimayambitsa kuchepa kwa chilakolako chofuna kudya.
• Kuletsa mapangidwe a mafuta owonjezera mu chiwindi.
• Kuchepetsa kwamphamvu zamafuta m'thupi kudzera mu chakudya.

Kuti mugwiritse ntchito Metformin kuti muchepetse kunenepa, ziyenera kumvetsedwa kuti ntchito yake yayikulu ndikupanga zinthu zomwe zimapangitsa kuti mafuta, osati minofu minofu, apangidwe. Chifukwa chake, pochita komanso osavulaza thupi kuchepa thupi, malinga ndi ndemanga zambiri zamankhwala, onse odwala ndi madokotala, zinthu zabwino ziyenera kupangidwa:

• Kanani zotsekemera ndi ufa, komanso zopangidwa nthawi yomweyo (Zakudyazi, chimanga, mbatata zosenda).
• Chepetsani kudya kwa kalori.
• Chitani masewera olimbitsa thupi nthawi zonse.

Mukamagwiritsa ntchito Metformin poonda, mulingo woyenera kukhala 500 mg / tsiku, ndipo chakudyacho chikuyenera kuperekedwa musanadye chakudya chamadzulo komanso chakudya chamadzulo. Kuunikira kwa wodwala mankhwala kumawonetsa kuyenera kwake pakuchepetsa thupi, koma kugwiritsa ntchito Metformin pazolinga izi ndikosavomerezeka popanda kufunsa adokotala komanso azakudya.

Zotsatira zoyipa

Ngakhale zizindikiritso zambiri zogwiritsidwa ntchito, Metformin ikhoza kuyambitsanso kuwonetsa zina zosasangalatsa kuchokera pamatumbo am'mimba, omwe ali zotsatira zoyipa za mankhwalawa:

• Kusilira ndi mseru.
• Chilichonse chofooka kapena kusakhalapo kwathunthu.
• Kukwiya kwam'mimba, kutsegula m'mimba, kupweteka kwam'mimba.

Nthawi zambiri, zizindikiro zotere zimawonekera koyambirira kwenikweni kwa chithandizo ndipo, malinga ndi odwala, amadzinyikira okha.

Zotsatira zoyipa za machitidwe ena ndizofunika kwambiri:

• Hypovitaminosis B12 ndi lactic acidosis.
• Megaloblastic anemia.
• Hypoglycemia.
• Zotupa pakhungu monga sayanjana.

Malangizo apadera ogwiritsa ntchito ndi kuwunika kwa wodwala

Monga mankhwala ena aliwonse, omwe ali ndi zotsutsana ndi mawonekedwe ake ogwiritsira ntchito, Metformin imafunikira chisamaliro mosamala muyezo ndi nthawi yoyendetsera.

Makamaka, pakukhazikitsa, ndikofunikira kuyang'anira ntchito ya aimpso kawiri pachaka, komanso mawonetseredwe a myalgia, ndikofunikira kudziwa zomwe zili mu plasma lactate. Kuphatikiza apo, serum creatinine iyenera kuyang'aniridwa miyezi isanu ndi umodzi iliyonse, makamaka kwa odwala okalamba.

Mukamamwa Metformin osakanikirana ndi mankhwala a sulfonylurea, ndikofunikira kuyang'anitsitsa kuchuluka kwa shuga m'magazi.

Ngati pali matenda a genitourinary system kapena matenda a bronchopulmonary, muyenera kudziwitsa dokotala wanu za izi.

Kumwa mankhwalawa sikukhudza kuyendetsa galimoto komanso kusokoneza ntchitoyo ndi machitidwe.

Kuphatikizidwa kwa Metformin ndi ena kumatha kubweretsa kukulira kwa zochitika za hypoglycemic zomwe zimadziwika ndi kuwonongeka kwa kukumbukira, momwe zimaletsedwa kuyendetsa galimoto ndikuchita zina zomwe zili zowopsa ndipo zimafuna chidwi chochulukirapo komanso kuchitapo kanthu.

Malinga ndi ndemanga yokhudza mankhwalawa "Metformin", ngakhale akuwopseza kwambiri pazotsatira zoyipa, amawonedwa kawirikawiri kapena pang'ono. Ndipo, chomwe chimadziwika kwambiri ndi okonda maswiti, mukamamwa mankhwalawo, ndizotheka kugula chidutswa cha keke kapena maswiti, ngakhale mutakhala pang'ono.

Komanso, pakuwunika kwa odwala matenda ashuga, pali mwayi wowonjezereka wokhala ndi pakati pamene mukumwa Metformin, yomwe imathandiza osati kungochotsa matendawa, komanso kuti banja likhale losangalala.

Mkazi amene akufuna kukhala ndi mawonekedwe abwino sangathe kuyimitsidwa. Nthawi zina amagwiritsa ntchito njira zosakwanira. Mwachitsanzo, odwala matenda ashuga amatchulidwa Metformin kuti achepetse thupi. Palibe wazopatsa thanzi amalimbikitsa kugwiritsa ntchito mankhwalawa popanda chifukwa chomveka. Komabe, azimayi ena amapereka chithandizo paokha, ngakhale atakhala kuti ali ndi zotsutsana komanso kuthekera kokudwalani.

Limagwirira ntchito "Metformin" kuwonda

"Metformin" imalembedwa kwa anthu omwe amalandira insulin. Amagwiritsidwa ntchito ndi madokotala kuyang'anira kuchuluka kwa insulin m'magazi a wodwalayo ndikuchepetsa thupi ngati izi sizingatheke ndi zakudya komanso zolimbitsa thupi. Zimalepheretsa hyperinsulinemia (kuwonjezera kuchuluka kwa mahomoni m'magazi kuti akhale ndi mfundo zofunika), zomwe, mwa odwala omwe ali ndi vuto la shuga ndizomwe zimapangitsa kuti munthu azikhala ndi thupi lolemera komanso kupezeka kwa matenda a mtima.

Metformin siyimakhudzanso kupanga kwa insulin.

Imasunga kuchuluka kwa mahomoni m'malo osasunthika, kotero kuti wodwalayo amazimiririka nthawi zonse akumva njala.

• Ngati mankhwalawa atengedwa ndi chakudya, zochuluka za zomwe zimagwira zimakhazikika m'matumbo a matumbo. Potere, metformin imalepheretsa kuyamwa kwa shuga m'zakudya ndikuthandizira kuti igwiritsidwe ntchito mwachangu.
• Ngati mankhwalawo amamwa mosiyana ndi chakudya, amatha bwino kumamwa ndi mucosa. Pafupifupi theka la zofunikira zake zimalowa m'magazi, ndipo kuchokera pamenepo zimafalikira mpaka ziwalo zazikulu.

Thupi limapezeka m'chiwindi, pomwe limalepheretsa zomwe zimachitika mthupi la kutembenuka kwa mankhwala osagwiritsa ntchito carbohydrate kukhala shuga. Zotsatira zake, kuchuluka kwa shuga kumalowa m'magazi kumatsika.

Zakudya zomanga thupi ndi gwero lalikulu lamphamvu. Ngati kudya kwawo kapena kapangidwe kake kamachepa, thupi limayamba kuwononga mafuta. Chifukwa chake, anthu omwe amamwa metformin amatha kutsitsa thupi.

Mankhwala amathandizira chiwopsezo cha maselo ku insulin, chifukwa minofu yamtunduwu imayamba kudya glucose mwachangu.

Zakudya zomanga thupi zimalowa m'maselo kuchokera m'magazi. Milingo ya shuga imachepetsedwa kukhala yokhazikika. Pamabwera kamphindi, pamene glucose onse amwedwa, ndi zomwe zimachokera kunja, ndipo zomwe zimapangidwa ndi thupi, zimangodziwononga zokha kuti zilandire mphamvu. Palibe chowonjezera chomwe chimatsalira, zomwe zikutanthauza kuti palibe malo osungidwa omwe amapangidwira mafuta osiyanitsidwa.

Kuchiza kuyenera kutsagana ndi zakudya zapadera komanso zolimbitsa thupi. Onetsetsani kuti mulibe zakudya zonse zothamanga: ufa, maswiti, confectionery, zipatso zokoma kwambiri, chokoleti. Kupanda kutero, mavuto azakudya sangapewe. S shuga iliyonse chifukwa cha kulephera kulozeka m'matumbo imakhumudwitsa makoma ake ndikupita kutuluka.

Malangizo ogwiritsira ntchito

Malangizowo akuwunikiranso kuti wodwala aliyense amapatsidwa mankhwala ndi dokotala. Mankhwalawa amayamba kumwa ndi 500-1000 mg patsiku. Kenako, kutengera glucose m'magazi, patsiku la 10-15 mankhwalawa akhoza kuchuluka mpaka 1700-2000 patsiku. Kuchuluka kwakukulu komwe kumatha kudya tsiku lililonse ndi 3000 mg.

Kuti muchepetse zotsatila za kumwa, mlingo umagawidwa ndi 2-3. Mapiritsiwo amamezedwa lonse, osafuna kutafuna, ndi madzi pang'ono musanadye kapena kale ndi chakudya.

Zotsatira zoyipa zikachitika, dokotalayo amasintha mankhwalawo.Musanamwe Metformin, muyenera kuwerengera magazi ndikuwunika momwe amasinthira.

Sipayenera kupatsidwa anthu:

• pambuyo opaleshoni yayikulu
• kukhala ndi matenda amtima, matenda aimpso, chiwindi, mavuto kupuma,
• ndi kuchepa kwa lactase ndi tsankho lactose,
• matenda opatsirana
• amene adayezedwa x-ray pasanathe masiku awiri asanamwe mankhwalawo.
• zidakwa
• woposa zaka 60 wogwira ntchito molimbika.

Mankhwalawa satengedwa ndi mankhwala ambiri: antipsychotic, antidepressants, akulera, mahomoni olimbikitsa chithokomiro.

Mapiritsi a zakudya sangaphatikizidwe ndi zakudya zamafuta ochepa. Osachepera 1000 kcal amayenera kudyedwa patsiku.

Zotsatira zoyipa kwambiri (mu 18-20% ya milandu) ndizakudya zam'mimba, zong'amba pamimba, kutsutsana ndi chakudya, mutu. Poyerekeza ndi kugwiritsa ntchito nthawi yayitali, akusowa vitamini B12.

Misonkho yokwanira ndalama zomwe mukukambirana ndi:

• Forethine
• Siofor
• Chikwanje,
• Glformin
• Bagomet.

Onsewa ali ndi kapangidwe kofananira ndi mawonekedwe amachitidwe, ndipo amasiyana muzipangidwe ndi mtengo. Mwa zina mwa dzina la Metformin, ndemanga zotsutsa kwambiri za mapiritsi a Ozone ndi. Ena amati samva kuti zimawakhudza bwanji. Nthawi zambiri, zokonda zimaperekedwa kukonzekera komwe Gedeon Richter amapanga.

Metformin kapena Glucophage, ndibwino?

Mapiritsi a Metformin ali ndi wowuma, pomwe Glucofage imadzaza ndi macrogol. Chifukwa chake, chomalizachi chimayambitsa zotsatira zoyipa ndi chimbudzi.

Kugwiritsa ntchito kwa mankhwala "Metformin" ngati njira yochepetsera thupi kumatsutsana. Mwachidziwikire, sizingatheke kufotokozera popanda umboni. Kodi ndizoyenera kuyika thanzi lanu pachiwopsezo, ndikuyembekeza kutaya makilogalamu awiri, kapena mwina kuyeseza, kungodalira zakudya zoyenera komanso kuchita masewera olimbitsa thupi? Yankho likuwoneka kukhala lodziwikiratu.

Metformin ndi mankhwala omwe amagwiritsidwa ntchito masiku onse kudziwa matenda a shuga. Kuphatikiza apo, imagwiritsidwa ntchito kuthana ndi kunenepa kwambiri ndikuchotsa ovary ya polycystic mu gynecology. Mankhwala amakulolani kuti muchepetse kunenepa kwambiri, kumachepetsa mulingo, koma sikuyambitsa zovuta zoyipa.

Kutenga Metformin ndi njira yodalirika yopewera kukula kwa zovuta za matenda ashuga, monga kugunda kwa mtima ndi sitiroko, potenga nthawi yayitali moyo wa odwala. Pali umboni kuti Metformin amateteza anthu ku mitundu ina ya zotupa za khansa.

Mtengo wa mankhwalawa ndi wotsika, chifukwa makampani ambiri azamankhwala akupanga nawo ntchito yake.

Zowonetsa kutenga Metformin, zomwe zimaperekedwa mu malangizo a boma:

Type 2 shuga.

Type 1 shuga mellitus odwala omwe ali ndi kunenepa kwambiri komanso kukana insulin.

Komabe, zenizeni, anthu ambiri amatenga Metformin kuti achepetse thupi. Amanenanso zochizira polycystic ovary syndrome mwa akazi. Kuchita izi kumawonjezera mwayi wodwala kudziwa bwino.

Kuphatikiza pa kumwa mankhwalawa, amayi omwe ali ndi vuto la ovary polycystic ayenera kutsatira zakudya zotsika komanso zolimbitsa thupi. Izi zimawonjezera mwayi woganiza bwino.

Metformin: malangizo ogwiritsira ntchito

Kodi mankhwalawa amagwira ntchito bwanji?

Metformin amalembera odwala matenda a shuga a mtundu wachiwiri, ndipo nthawi zina amaphatikizidwa ndi mankhwala othandizira odwala matenda ashuga amtundu woyamba. Mankhwalawa amathandizira kuchepetsa shuga m'magazi pamimba yopanda kanthu ndikatha kudya, komanso amakupatsani mphamvu yochepetsa hemoglobin.
Kumwa mankhwalawa kumapangitsa kuti muchepetse kupanga kwa shuga m'chiwindi, komanso kumalepheretsa kuyamwa kwa mafuta ambiri m'matumbo. Chifukwa cha Metformin, ndizotheka kuwonjezera chidwi cha maselo kuti apange insulin.Zikondamoyo pa mankhwala sizipanga insulin yambiri, zomwe zimalepheretsa kukula kwa hypoglycemia.

Mankhwalawa sadziunjikira m'thupi. Ambiri a iwo amachotseredwa ndi impso. Mankhwala omwe akhala akugwiritsidwa ntchito kwa nthawi yayitali atagwiritsidwa ntchito, mwachitsanzo, Glucofage Long, Metformin imatengedwa nthawi yayitali ngati mungayerekeze nthawi ino ndi mapiritsi a nthawi zonse.
Malinga ngati munthu ali ndi vuto linalake la impso, Metformin iyenera kuyikidwa mosamala.

Mukatenga nthawi yanji

Mankhwalawa amalembedwa kwa odwala omwe ali ndi matenda a shuga 2, omwe amakhala ndi kunenepa kwambiri komanso omwe ali ndi chiwopsezo chochepa cha maselo a insulin.
Kuchiza ndi metformin kuyenera kuchitika motsutsana ndi maziko azokwanira zolimbitsa thupi komanso kudya zakudya zochepa.

Mankhwala sangathe kumwa

Contraindication chithandizo ndi Metformin:

• Matenda a shuga ketoacidosis.
• Matenda a shuga.
• ndi kulowetsedwa kwa glomerular ya 45 ml / min ndi pansi.
• Magazi a creatinine ndi 132 μmol / L kwa amuna ndi 141 μmol / L kwa akazi.
• Kulephera kwa chiwindi.
• Matenda opatsirana omwe ali pachimake gawo.
• Kuthetsa madzi m'thupi

Zomwe muyenera kulabadira mwapadera

Ngati wodwala atamuchita opaleshoni, kapena kumuyesa X-ray pogwiritsa ntchito kusiyanitsa, ndiye kuti ayenera kusiya kumwa Metformin masiku awiri isanachitike.
Nthawi zina odwala amatha kukhala ndi vuto lalikulu lactic acidosis. Izi zimatsatiridwa ndi kuchepa kwa magazi pH mpaka 7.25, yomwe imabweretsa chiwopsezo chachikulu osati thanzi komanso moyo. Chifukwa chake, pamene zizindikiro monga kupweteka kwam'mimba, kufooka kowonjezereka, kusanza ndi kupuma movutikira kuonekera, ambulansi iyenera kuyitanidwa.
Monga lamulo, lactic acidosis imayamba pokhapokha ngati munthu wamwa mlingo waukulu kwambiri wa mankhwalawo, kapena chithandizo chinkachitika ngati pali zotsutsana. Nthawi zina, chithandizo cha Metformin sichimatsogolera pakukula kwa lactic acidosis.

Momwe mungatengere komanso mlingo

Kuchiza kuyenera kuyamba ndi mlingo wochepa wa 500-850 mg patsiku. Pang'onopang'ono, imawonjezeka ndikubwera mpaka 2550 mg pa tsiku, kumwa piritsi limodzi la 850 mg katatu patsiku. Kuchulukaku kuyenera kuchitika nthawi 1 m'masiku 7-10.
Ngati munthu agwiritsa ntchito mankhwala okhala ndi nthawi yayitali kuchitira mankhwala, tsiku ndi tsiku mlingo umachepetsedwa mpaka 2000 mg. Imwani mankhwalawa 1 nthawi patsiku, musanakagone.

Zotsatira zoyipa zimafotokozedwera mu mawonekedwe amisala pakuchitika kwa dongosolo la m'mimba. Munthu amadwala matenda otsegula m'mimba, nseru, kusanza, chilakolako chake cha thupi chikamakulirakulira, kukoma kwake kumatha kupotozedwa. Monga lamulo, chisokonezo chotere chimawonedwa m'masiku oyambira okha kuyambira pachiyambire mankhwala.
Kuchepetsa mwayi wokhala ndi zotsatirapo zochepa, chithandizo chikuyenera kuyambitsidwa ndi Mlingo wochepa.
Ngati wodwala ali ndi zotupa pakhungu komanso kuyabwa, ndiye kuti izi zimafunikira upangiri wa udokotala, chifukwa zingasonyeze kuti munthu alibe vuto lakelo.
Pa chithandizo cha nthawi yayitali, kuperewera kwa vitamini B12 m'thupi ndikotheka.

Kuchepetsa ndi pakati

Pakubala kwa mwana komanso poyamwitsa, mankhwalawa saikidwa kwa akazi. Komabe, nthawi zambiri amagwiritsidwa ntchito pochiza polycystic ovary syndrome. Ngati panthawiyi mayi ali ndi pakati, ndiye kuti palibe chowopsa chomwe chidzachitike. Ndikofunika kuti musamwe mankhwalawo mukazindikira za vuto lakelo.

Ngati mlingo waukulu watengedwa

Ndi mankhwala osokoneza bongo, hypoglycemia samakula, koma lactic acidosis imatha kuchitika (pafupifupi 32% ya milandu). Munthu ayenera kugonekedwa kuchipatala mwachangu. Kuti muchotse mankhwalawo mwachangu m'thupi, kuyimba pamafunika. Mofananamo, chithandizo chamankhwala chimachitika.

Kuchita ndi mankhwala ena

Ndi munthawi yomweyo makonzedwe a Metformin omwe ali ndi insulin, kuchepa kwakukulu kwa shuga m'magazi ndikotheka.Komanso, mankhwalawa amatha kuthana ndi mankhwala kuti muchepetse kuthamanga kwa magazi komanso ndi mankhwala othandizira.

Fomu yotulutsidwa, malo osungira

Mankhwalawa amatha kupezeka pamankhwala a 500, 850 ndi 1000 mg. Ikupezeka piritsi.
Kutentha kozungulira sikuyenera kupitirira 25 digiri. Moyo wa alumali umasiyana zaka zitatu mpaka zisanu.

Prediabetes ndi Metformin

Metformin itha kumwa mankhwala onenepa a prediabetes. Izi zikuchepetsa mwayi wokhala ndi matenda ashuga amtundu wa 2.

Choyamba muyenera kuyesera kuchepetsa thupi ndi zakudya. Ngati zotsatira zake sizikwaniritsidwa, ndiye kuti mutha kulumikiza mankhwala. Kuphatikiza pa zakudya, munthu ayenera kuwonjezera zochita zake zolimbitsa thupi: kuchita masewera olimbitsa thupi, kuyenda kwambiri, kuthamanga. Mofananamo, ndikofunikira kuyang'anira kuchuluka kwa kuthamanga kwa magazi, komanso kuchuluka kwa shuga m'magazi, kuphatikizapo kusala kudya.

Metformin si mankhwala. Zimatengedwa mu moyo wonse, popanda zosokoneza, tsiku ndi tsiku.

Ngati munthu wayamba kutsegula m'mimba kapena matenda ena am'mimba, ndiye kuti ichi sichiri chifukwa chosiya kumwa. Ndizotheka kuti muchepetse mlingo kwakanthawi.

Kamodzi pa miyezi isanu ndi umodzi, kuyezetsa magazi kuyenera kutengedwa kuti athe kudziwa kuchuluka kwa vitamini B12 m'thupi. Ngati pali kuchepa, ndiye kuti iyenera kutengedwa padera. Palinso malingaliro kuti mutenge vitamini B12 ngati njira yothanirana.

Zisonyezero zogwiritsira ntchito Metformin

Gawo logwira la mankhwala a hypoglycemic ndi mawonekedwe ake ndi metformin. Pazinthu zothandizira za piritsi la mankhwalawa, mankhwala a magnesium stearate, wowuma, talc amagwiritsidwa ntchito. Mankhwalawa ndi a gulu la Biguanides.

The pharmacological zotsatira ndi zoletsa shuga - mapangidwe a glucose chifukwa cha kagayidwe kachakudya njira mu chiwindi. Mankhwala amachepetsa mayamwidwe am'mimba m'matumbo, amalimbikitsa kugwiritsidwa ntchito kwa shuga. Amachepetsa kuthekera kwa hypoglycemia ndi hyperinsulinemia, amathandizira kuyang'anira kulemera, komanso amalepheretsa kukula kwa mtima pathologies (diabetesic angiopathy).

Zochita za metformin sizikhudzanso kupanga kwa insulin ndipo sizipangitsa kuti pakhale chinsinsi. Mankhwala amachepetsa zomwe zimakhala ndi lipoprotein m'magazi. Katunduyu amagwiritsidwa ntchito pochotsa kunenepa kwambiri.

• matenda ashuga ketoacidosis,
• Mimba, kuyamwa,
• zaka za ana
• aimpso ndi chiwindi kulephera,
• malungo
• vuto la mtima
• uchidakwa.

Mitundu ya Metformin ndi mankhwala osokoneza bongo amadziwika pamodzi ndi insulin. Mlingo umatsimikiziridwa ndi payekha pakuthandizira endocrinologist. Mlingo woyambitsidwa woyamba ndi 500 mg / tsiku (piritsi 1).

Mayina amalonda

Muzochita zamankhwala, onse mankhwala oyambira Metformin, ma analogi ake, ndi ma generic opanga pamtengo wotsika mtengo amagwiritsidwa ntchito:

• Metformin-Teva (wopangidwa ku Israeli). Mankhwala enieni mu mawonekedwe apiritsi. Mtengo - kuchokera ku ma ruble 80.
• Metaformin Long (ntchito yayitali).
• Metformin-Richter (mankhwala aku Russia). Mtengo kuchokera ku 180 rub.
• Metformin-Zentiva (mankhwala a kampani ya mankhwala ku Slovak). Mtengo kuchokera pa 120 rub.
• Metformin-Kanon (wopangidwa ndi kampani yaku Russia ya zamankhwala yotchedwa Kanonfarma Production). Mankhwalawa amapezeka m'mapiritsi. Mtengo wotsika - kuchokera ku ma ruble 90.

Ma analogu a Metformin ali ndi chinthu chogwiritsidwa ntchito pa mlingo wa 500 mpaka 1000 mg. Mankhwalawa ali ndi zochizira zofanana.

Kuzindikira kwa shuga - ingomwani tsiku lililonse.

Metamorphine Long ndiwabwino m'njira yoti njira zochizira matendawa zimatenga nthawi yayitali poyerekeza ndi mankhwala achilengedwe omwe ali mgululi.

Kukonzekera kwa pharmac okhala ndi mawonekedwe osiyana, koma okhala ndi vuto lofanananso ndi mankhwala, amatchedwa ma analogues. Kampani iti, yomwe ndi yabwino kuchokera pazofanizira za Metformin, idzatsimikizidwe ndi adokotala.Mankhwala osiyanasiyana a hypoglycemic ali pamsika.

Ma fanizo odziwika bwino a Metformin ndi awa:

Kuti muthane ndi funso momwe mungasinthire Metamorphine, munthu ayenera kuganizira za zovuta zoyambitsidwa ndi zigawo zina za mankhwala. Ma analogs ndi ma synophms amasiyana pama kapangidwe kosiyanasiyana ka zinthu zowonjezera ndi zotumphukira za mapiritsi ndi makapisozi.

Pali kuthekera kwa kusintha kwa zinthu zina mukamatenga Metformin. Pankhaniyi, muyenera kulumikizana ndi dokotala-endocrinologist.

Mukamasankha mankhwala a hypoglycemic, munthu sayenera kuyang'ana kwambiri pamtengo;

Mankhwala a hypoglycemic, omwe ndi amodzi ofunikira kwambiri a Metformin. Amapereka kuchepa kwa basal glucose level. Zimalimbikitsa kukhathamira kwa glucose pogwiritsa ntchito minofu. Amachepetsa kuyamwa kwa chakudya cham'mimba.

Siofor 1000 imalimbikitsa kaphatikizidwe ndi kudziunjikira kwa glycogen m'maselo a chiwindi. Amasintha kagayidwe ka lipid. Amagwiritsidwa ntchito kuti achepetse kunenepa kwambiri. Imakhazikika mkhalidwe wa odwala omwe ali ndi matenda a shuga a 2.

Siofor 1000 imapezeka mu piritsi la 1000 mg yogwira ntchito, mu 60 ma PC. pamtengo wa ma ruble 369. Siofor 500 ndi Siofor 850 amapangidwa ndi mitundu yoyenera ya metformin 500 mg ndi 850 mg.

Kuchepetsa shuga ku France kuchokera ku gulu la mankhwala a Metformin analogues.

Timapereka kuchotsera kwa owerenga tsamba lathu!

Amagwiritsidwa ntchito pochiza matenda a shuga. Zisakhudze kuchuluka kwa glucose mwa anthu omwe amakhala ndi chakudya chambiri chama metabolism. Amapezeka mu 1000 mg m'mapiritsi a 60 zidutswa. Mtengo - 322 rub. Glucophage Long imakhala ndi 500 mg, 750 mg, 1000 mg ya metformin. Imakhala nthawi yayitali ya mankhwala.

Mankhwala apiritsi a Russia opangidwa ndi hypoglycemic effect.

Zilibe mphamvu mwachindunji pakupanga insulin. Amachepetsa ndende ya triglycerides ndi lipoproteins zovulaza. Amachepetsa mafuta m'thupi. Amawongolera kuchuluka kwa insulin yomangidwa komanso yaulere. Wolemba Akrikhin OJSC. 500 mg, 850 mg, mapiritsi a 1000 mg. Mtengo wake umachokera ku ma ruble 120.

Mankhwala ophatikizika a hypoglycemic (opangidwa ku Argentina). Kuphatikiza pa metformin, ili ndi glibenclamide yogwira.

Mankhwala amachepetsa kuchuluka kwa shuga m'magazi seramu. Imayambitsa kagayidwe kazakudya, imalepheretsa kupanga shuga m'chiwindi ndikutulutsa kwa mafuta m'magazi. Mosangalatsa zimakhudza kagayidwe ka lipid.

Glibenclamide, mosiyana ndi metformin, imakhudza kugwira ntchito kwa maselo otulutsa insulin, amathandizira zochitika zawo zachinsinsi.

Bagomet imapezeka m'mapiritsi a 850 mg (60 phukusi lililonse) pamtengo wa 136 rubles.

Oral hypoglycemic mankhwala. Amapezeka ngati mapiritsi okhala ndi interic.

Malingaliro a madotolo

Endocrinologists awona kuchuluka kwa zopempha za matenda ashuga.

Vutoli limachulukirachulukira ndikusowa kwa chakudya, komwe kumasokoneza kagayidwe kazakudya. Mankhwala ochepetsa shuga a magazi amathandiza odwala kukhazikika. Kuchokera kwa othandizira a hypoglycemic, madokotala amapatula Metaformin ndi ma analogues, omwe ali ndi chofanana ndi achire.

Olga Dmitrievna (endocrinologist)

Metformin adatsimikizira kuti ndi woyenera kwambiri pothandizira matenda a carbohydrate metabolism kwa odwala omwe ali ndi matenda osokoneza bongo. Ndiwothandiza makamaka koyambirira kwa chitukuko cha matenda a zamitsempha. Zimaphatikizidwa ndi mankhwala ndi othandizira ena odwala matenda ashuga. Mwa minus, kupezeka kwa vuto la m'matumbo ngati zotsatira zoyipa titha kuzindikira. Pali tsankho lililonse pazamankhwala.

Konstantin Leonidovich (wazakudya)

Anformate a Metformin agwiritsidwa ntchito kukonza ndikuchepetsa thupi pochotsa kunenepa kwambiri. Zinali zotheka kukwaniritsa zabwino pamankhwala. Koma panali zovuta zina. Odwala adadandaula ndi mseru, kutsekula m'mimba, kumatulutsa. Chilichonse chamadya chinatheratu, chisangalalo chikukula.

Ndemanga Zahudwala

Matenda a 2 a shuga amakupatsani mwayi wogwira ntchito, koma amachepetsa moyo. Odwala amakakamizidwa kumwa mankhwala amoyo wonse. Milandu yakuchiritsa kwathunthu matendawa ndiyosowa. Chithandizo cha mankhwala amatha kupititsa patsogolo mkhalidwe wa odwala pamlingo wovomerezeka.

Veronika Sergeevna (wodwala matenda ashuga kwa zaka zoposa 20)

Ndine wonenepa kwambiri. Kulemera kuposa 100 kg. Sanayembekezere chozizwitsa kuti atenge Metformin. Kulemera kwake komwe kunkakhala 34 kg, ndiye kuti kunayamba kuchepa pang'onopang'ono. Nthawi ndi nthawi, kutsegula m'mimba kumachitika. Koma zotsatira zake ndizochepa. Kuphatikizanso ndikuti mankhwalawa ndiokwera mtengo. Shuga akhoza kuchepetsedwa. Vutoli nthawi zambiri limakhala labwinoko kuposa mapiritsi amenewa.

Potsatira lingaliro la dotolo, adayamba kumwa Metformin kuti achepetse thupi. Ndingonena kuti ngati panali chifukwa chomwa mapiritsi awa, ndiye kuti ndikosafunika kwenikweni. Sindinazindikire momwe zimakhalira. Ndikudziwa kuti kuwonjezera pa mapiritsi, muyenera kudya zakudya ndikukhala olimba. Kenako zidzatha kuthana ndi vuto la mapaundi owonjezera.

Metformin, kuphatikizapo ma analogues angapo, amagwiritsidwa ntchito pochita endocrinological kuti apititse patsogolo odwala omwe ali ndi matenda a shuga. Amagwiritsidwanso ntchito mu gynecology pochiza ma cystic misa komanso kuwonda kunenepa kwambiri. Mankhwalawa akuwonetsa zotsatira zabwino zochizira. Mtengo wotsika wa ma analogu ena umakwanira chifukwa cha zovuta.

Matenda a shuga nthawi zonse amayambitsa zovuta zakupha. Mwazi wamagazi ochulukirapo ndi woopsa kwambiri.

Aronova S.M. adafotokoza za chithandizo cha matenda ashuga. Werengani kwathunthu

Zakudya ndi Metformin

Kuti muchepetse kunenepa kwambiri, komanso munthawi ya matenda a shuga, muyenera kutsatira zakudya zochepa zamafuta. Sikokwanira kungodula zopatsa mphamvu za tsiku ndi tsiku ndi kuchuluka kwa mafuta omwe adawonongeka - izi sizingakulolani kuti musunge shuga wambiri. Kuphatikiza apo, kudya zakudya zochepa zopatsa mphamvu kumathandizanso kuti munthu azikhala ndi chidwi chofuna kudya, zomwe zingayambitse kudya kwambiri, kusweka komanso kuchuluka kwa thupi.

Ngati simukuchepetsa kuchuluka kwa chakudya chamafuta omwe mumamwe, ndiye kuti simungathe kukwaniritsa zochizira pakumwa mapiritsi ngakhale mutaba jakisoni wa insulin. Kudya zakudya zoyenera kumakuthandizani kukhala odzala ndi kupewa kunenepa kwambiri.

Ndi mankhwala ati oti musankhe: Metformin, Siofor kapena Glucofage?

Glucophage ndi mankhwala oyamba ozikidwa metformin. Siofor ndi mankhwala ena omwe ali ndi fanizo.

Glucophage Long - chida chokhala ndi mphamvu yokhalitsa. Kuwongolera kwake sikungapangitse kuyambitsa zovuta pamtundu wa m'mimba kuposa mankhwala ochiritsira ofanana ndi metformin. Glucophage Long imatengedwa asanagone, zomwe zimalepheretsa kulumpha m'mawa m'magazi.

Mtengo wa Glucofage ndi Glucophage Long kukonzekera sikokwanira. Chifukwa chake, sizikupanga nzeru kusinthira kumafanizo awo. Chofunika kupulumutsa sichitha.

Metformin yokhala yayitali kwa nthawi yayitali - ndi kusiyana kotani?

Ngati munthu watenga metformin wokhazikika, mankhwalawa amamwetsa mwachangu kwambiri. Pambuyo 4 mawola kudya magazi, ambiri pazomwe amagwira zimawonedwa. Fotokozerani mankhwala katatu patsiku ndi chakudya.

Munthu akatenga metformin yomasulidwa kwa nthawi yayitali, mankhwalawa amamwa nthawi yayitali, koma amakhalanso nthawi yayitali. Fotokozerani mankhwalawa 1 nthawi patsiku, musanakagone. Izi zithandiza kupewa m'mawa kwambiri.

Metformin wokhala ndi nthawi yayitali samayambitsa zotsatira zoyipa mwanjira yakuphwanya magwiridwe antchito. Komabe, amawongolera kuchuluka kwa shuga masana.Chifukwa chake, ndikulimbikitsidwa kuvomerezedwa kwa anthu omwe ali ndi shuga othamanga kwambiri. Mankhwala oyamba a metformin ndi Glucofage Long. Pogulitsa palinso fanizo la mankhwalawa ndi mphamvu yayitali.

Zotsatira za metformin pachiwindi. Mafuta hepatosis ndi metformin

Metformin sayenera kumwedwa ndi kuwonongeka kwambiri kwa chiwindi, mwachitsanzo, ndi matenda a cirrhosis kapena chiwindi. Ndi mafuta a chiwindi hepatosis, kugwiritsa ntchito kwake, m'malo mwake, kudzabweretsa zabwino zambiri. Kuphatikiza apo, wodwalayo afunika kutsatira zakudya zamagulu ochepa. Mukamatsatira malangizowa, mudzatha kukonza moyo wawo mwachangu. Fatpat hepatosis imatha kugonjetsedwa kudzera muzakudya zoyenera komanso Metformin. Mofananamo, munthu amayamba kuchepa thupi.

Metformin ndi mahomoni

Metformin siyimakhudzanso potency ya amuna ndi kuchuluka kwa magazi a testosterone.

Ndi polycystic ovary syndrome mwa akazi, mahomoni ambiri ogonana amuna amawonedwa, komanso kusokonezeka kwa metabolic ndi insulin kukana. Kutenga metformin, mwachitsanzo, Siofor, kuchotsa vuto lomwe liripo. Mankhwalawa amathandizanso kukongoletsa maimidwe achikazi ndipo kumawonjezera mwayi woti agwire bwino ntchito.

Ndi mankhwala ati omwe amayenera kumwa m'malo mwa metformin chifukwa cha kulephera kwa impso?

Kutenga Metformin chifukwa cha kulephera kwa impso nkoletsedwa. Sichikuperekedwa kwa odwala matenda ashuga omwe muyezo wama glomerular amatsitsidwa mpaka 45 ml / miniti.

Ndi kulephera kwa aimpso, mutha kumwa mankhwala monga Januvia, Galvus, Glyrenorm. Kukhazikitsidwa kwa jakisoni wa insulin ndikothekanso. Mulimonsemo, dokotala yekha ndiye ayenera kupereka mankhwala kwa odwala omwe ali ndi mavuto otere.

Metformin imakulitsa moyo - sichoncho?

Metformin bwino imathandizira kutalikitsa kwa moyo wa anthu omwe akudwala matenda ashuga, chifukwa amaletsa kukula kwa zovuta zovuta za matendawa.

Ponena za kuchuluka kwa chiyembekezo cha moyo mwa odwala omwe alibe matenda a shuga, palibe umboni wa sayansi pazowona izi. Komabe, kafukufuku wokhudza nkhaniyi wayambitsidwa kale.

Mutha kupezanso ndemanga kuti chithandizo ndi Glucofage chimachepetsa ukalamba. Izi zimatsimikiziridwa ndi anthu omwe samamwa mankhwala a shuga.

Prophylactic Metformin ndi mlingo wake

Ngati munthu ndi wonenepa kwambiri, ndiye kuti amatha kutenga Metformin kuti ikhale prophylactic. Mankhwalawa amakupatsani mwayi wochotsa ma kilogalamu angapo olemera kwambiri, komanso kuchepetsa matenda a cholesterol, omwe, amathandizanso kupewa matenda a shuga a 2.

Musanayambe mankhwala othandizira kupewa, muyenera kuphunzira malangizo oti mugwiritse ntchito ndikuonetsetsa kuti palibe zotsutsana.

Ndikulimbikitsidwa kuti muthe kutenga Metformin muli ndi zaka 35 mpaka 40, ngakhale palibe zomwe zasinthidwa pazomwezi. Kuphatikiza pa kuwongolera zolemetsa zamankhwala, muyenera kutsatira zakudya zochepa zamanyama. Tiyenera kumvetsetsa kuti kuchuluka kwa mapiritsi kumakhala kocheperako ngati mukupitiliza kudya mosayenera. Zomwe zimavulaza kwambiri ndizinthu zomwe zimakhala ndi shuga woyengetsa.

Anthu onenepa amafunika kumwa Metformin pa 2550 mg tsiku lililonse. Ngati mankhwalawa akuchitika ndi mankhwala okhala ndi mphamvu yayitali, ndiye kuti tsiku lililonse mlingo uyenera kukhala 2000 mg. Muyenera kuukweza bwino. Pakati pa sabata yoyamba, zidzakhala zokwanira kumwa 500-850 mg wa mankhwalawa patsiku. Izi zimathandizira kuti thupi lizolowerana ndi mankhwalawa.

Ngati munthu alibe vuto lolemera mopitirira muyeso, ndipo akufuna kutenga Metformin kuti aletse kukalamba koyambirira, ndiye kuti ndikokwanira kumwa 500-1700 mg ya mankhwalawa patsiku. Palibe zidziwitso zatsopano pankhaniyi.

Metformin imakupatsani mphamvu kuti muchepetse thupi popanda kuvulaza thanzi, chifukwa mankhwalawa samabweretsa zovuta zoyipa. Kuphatikiza apo, ndi chithandizo chake ndikotheka kutulutsa mtundu wa cholesterol ndi glucose m'magazi.

Popeza izi, sizodabwitsa kuti metformin imakonda kugwiritsidwa ntchito pakuchepetsa thupi. Zomwe zachitika ndikutenga zaka zopitilira 50. Mankhwala opangidwa ndi Metformin amapangidwa ndi makampani ambiri azamankhwala. Izi zimakuthandizani kuti musunge mtengo wa mankhwala oyambilira Glucofage pamlingo wotsika.

Pofuna kusokoneza kukula kwa zoyipa, metformin iyenera kutengedwa mu yaying'ono Mlingo woyamba. Musanayambe ndewu yolimbana ndi kunenepa kwambiri, muyenera kuonetsetsa kuti munthu alibe zotsutsana ndi mankhwalawa.

Kodi mungataye ndalama zingati ndi metformin?

Ngati simukumanganso zakudya zanu komanso osachita masewera olimbitsa thupi, ndiye kuti simungathe kuchita bwino chifukwa chochepetsa thupi kuposa makilogalamu 2-4.

Pambuyo miyezi 1.5-2 kuyambira poyambira kumwa metformin, zotulukapo zake palibe, ndipo kulemera kumakhalabe pamigawo yapitayi, izi zitha kuwonetsa kuti munthuyo ali ndi hypothyroidism. Onetsetsani kuti mwakumana ndi katswiri ndikuyesera mahomoni a chithokomiro.

Kutsatira zakudya zamafuta ochepa ophatikizidwa ndi metformin kumachepetsa kwambiri kulemera kwa makilogalamu 15 kapena kuposerapo. Kuti musunge izi, muyenera kutenga Metformin mosalekeza. Mutasiya mapiritsiwo, kulemera kwake kumatha kubwerera.

Elena Malysheva akuti metformin ndi njira yothanirana ndi ukalamba, koma sakusonyeza za kuthekera kwake kuchepetsa kunenepa kwambiri. Wowonetsa TV yemwe amadziwika kwambiri amavomereza kuti azitsatira zakudya zake, osamwa mankhwala osokoneza bongo. Komabe, muyeso wotere suyenera kwa munthu aliyense.

Metformin ndi hypothyroidism

Metformin imatha kutengedwa ndi hypothyroidism, popeza matendawa sasonyezedwa ngati cholakwira. Amaloledwa kugwiritsidwa ntchito molumikizana ndi mankhwala othandizira hypothyroidism. Ndizotheka kuti izi zikuthandizani kuti muchepetse thupi komanso mukhale ndi thanzi labwino. Komabe, adotolo ayenera kutenga nawo mbali pamankhwala a hypothyroidism, ndipo metformin ilibe vuto pamatendawa.

Metformin ndi matenda a shuga a 2

Metformin ndi mankhwala ochizira matenda amishuga amtundu wa 2, omwe amakupatsani mphamvu kuti muchepetse kuchuluka kwa shuga mutatha kudya komanso pamimba yopanda kanthu. Kugwiritsa ntchito metformin kumakupatsani mwayi wopewa kukula kwa zovuta zovuta za matenda, kuyimitsa kupitilira kwake komanso osavulaza thanzi. Metformin sayenera kuonedwa ngati machiritso ozizwitsa omwe angathandize kuthana ndi matenda ashuga. Zachidziwikire, panali zochitika pomwe munthu adalimbana ndi kunenepa kwambiri, ndipo matendawa amachepetsa, omwe amalola kusiya kugwiritsa ntchito metformin, koma zochitika ngati izi ndizosowa.

Ngati munthu amatenga metformin pafupipafupi komanso kwanthawi yayitali, ndiye kuti izi zimapangitsa kuti shuga, cholesterol ndi triglycerides m'magazi komanso kuchepa thupi.

Metformin ndi mankhwala otetezeka, motero, amapatsidwa mankhwala ochizira matenda osokoneza bongo komanso kunenepa kwambiri kwa ana opitirira zaka 10. Muyenera kuyamba kumwa mankhwalawa osachepera 500-850 mg patsiku, pang'onopang'ono kubweretsa kuchuluka kwa tsiku lililonse kwa 2250 mg. Ngati mankhwala Glucofage Long amagwiritsidwa ntchito pochiza, ndiye kuti mlingo wosakwana 2000 mg uyenera kumwedwa patsiku.

Kusunga matenda a shuga komanso kulemera pansi moyang'aniridwa ndi chithandizo chamankhwala sikungathandize. Wodwala amafunika kutsatira zakudya. Kupanda kutero, matenda a shuga akupitabe patsogolo ndikupangitsa kuti pakhale zovuta zazikulu.

Ndi mankhwala ati a metformin amene amachepetsa kwambiri shuga?

Zochizira matenda a shuga, glucophage ndiyabwino. Ichi ndi mankhwala oyambira pamtengo wotsika mtengo kwa anthu ambiri.Muthanso kutenga ma analog ake Siofor.

Kuti muchepetse shuga m'magazi kuti muuke m'mawa, mutha kugwiritsa ntchito mankhwala Glucofage Long. Amatengedwa asanagone, choncho amagwira ntchito usiku wonse. Njira izi zikapanda kukhazikika shuga, jakisoni wa insulin ingafunike. Kumbukirani kuti kuwuka kwam'magazi m'magazi kumathandizira kuti pakhale zovuta zamagulu a shuga. Chifukwa chake, kudumpha koteroko sikunganyalanyazidwe.

Ngati ndatsegula m'mimba kuchokera ku metformin kapena sizithandiza, ndiye kuti ndi chiyani chomwe chitha kusintha?

Ndikosavuta kupeza m'malo mwa metformin - ndi chinthu chapadera chochepetsera shuga m'magazi.

Chifukwa chake, choyamba muyenera kuyesa kupewa kupewa kutsekula m'mimba, kuti musayang'ane m'malo mwa metformin. Kuti muchite izi, yambani kulandira chithandizo cha mankhwala ochepa. Izi zimalola kuti thupi lizolowera mankhwalawo ndipo osayankhidwa chifukwa cholephera kugaya chakudya.

Pafupipafupi, mankhwala osasunthika othandizira. Chifukwa chake, kwakanthawi mutha kusintha m'malo mwa mapiritsi a Metformin.

Ngati kumwa mankhwalawa sikuchepetsa shuga m'magazi, ndiye kuti munthu atha kudwala matenda ashuga amtundu woyamba. Nthawi yomweyo, kapambayu wachotsa mphamvu zonse zomwe wasunga ndipo sangatulutsenso insulin. Kenako muyenera kusinthana ndi jakisoni wa timadzi timeneti. Kupanda kutero, munthu akhoza kufa chifukwa cha zovuta za shuga. Mapiritsi ayenera kutayidwa.

Pomwe metformin imatsitsa shuga m'magazi, koma izi sizokwanira, chithandizo chitha kuphatikizidwa ndi jakisoni wa insulin, koma muyezo waukulu.

Ngati munthu ali ndi thupi lochepa, koma amadwala matenda a shuga, ndiye kuti odwala oterowo amafunikira kupatsidwa insulin yomweyo. Mankhwala omwe amawotcha shuga sangakupatseni mwayi wolimbana ndi matendawa.

Kutenga metformin kumabweretsa kuwonjezeka kwa shuga m'magazi, chifukwa chake nchiani?

Metformin sichithandiza shuga m'magazi ngati mtundu wachiwiri wa shuga ndi woopsa, kapena munthu akapezeka ndi matenda a shuga a mtundu woyamba. Pankhaniyi, jakisoni wa insulin adzafunika, komanso kudya.

Dokotala atha kukuthandizani kuti mulandire kapena kuwonjezera kukonzekera kwa metformin ndi mankhwala monga: Diabeteson MV, Amaril, Manil, etc. Mankhwala aposachedwa kwambiri akupezekanso kuti mugulidwe, kuphatikizapo Januvia, Galvus, Forsiga, Jardins, etc. amakulolani kuti mukwaniritse zomwe mukufuna, ndiye kuti muyenera kusinthira jakisoni wa insulin. Kukana insulin mankhwala sayenera. Komanso, kumwa mankhwala kumatha kuchepetsa mlingo wa insulin nthawi 2-7. Izi zimakuthandizani kuti musunge shuga komanso kuti musawononge thanzi lanu.

Chithandizo cha matenda a shuga ndi metformin ndi jakisoni wa insulin

Nthawi zambiri, kukonzekera kwa metformin kumayikidwa mu regimen zovuta ndi jakisoni wa insulin. Izi zidzakonza kuchuluka kwa shuga pa 4.0-5.5 mmol / L.

Kupyola pakudya ndi pakamwa pobayira mankhwala owotcha shuga omwe shuga amatha kuyatsidwa ngati ali pachiwopsezo chomakula. Nthawi zina, Mlingo wambiri wa insulin amafunikira. Izi ndizothandiza kwa odwala omwe mulingo wa shuga sagwera pansi pa 6.0-7.0 mmol / L. Ndi zizindikirozi, zovuta za matenda ashuga zipita patsogolo, ngakhale osati mwachangu kwambiri.

Ngati tilingalira za njira zochizira matenda osokoneza bongo, choyamba tiyenera kuyesa kukonza zakuphwanya mothandizidwa ndi dongosolo lazakudya zopatsa thanzi komanso zolimbitsa thupi. Pokhapokha amayamba kumwa mankhwala owotcha shuga. Mphamvuyo ikakhala kuti singatheke, jakisoni wa insulini akuwonetsedwa. Mlingo wa insulin ufunika kuchepetsedwa ndi 25%, ngati nthawi yomweyo munthu alandire kukonzekera kwa metformin. Kuchulukitsa mlingo wa insulin panthawi ya mankhwala omwe amawotcha shuga amawopseza kukula kwa hypoglycemia.

Kuphatikiza pa njira zakuchiritsira zomwe zili pamwambapa, odwala matenda ashuga amafunika kusewera masewera.Zimathandizira kuchepetsa kuthamanga kwa matenda kapena, monga amatchedwanso, qi-run. Mutha kusinthanso zochita zanu zolimbitsa thupi ndi kuyenda kwa Nordic.

Metformin: kuvomera bwanji?

Metformin imatengedwa ndi zakudya, zomwe zimachepetsa chiopsezo cha mavuto.

Mapiritsi okhala ndi nthawi yayitali ayenera kumwa kwathunthu popanda kutafuna. Amakhala ndi matrix a cellulose, omwe amachititsa kuti pang'onopang'ono kumasulidwa kwachangu. Kuwonongeka kwa matrix kotere kumachitika m'matumbo. Pankhaniyi, kusintha kwa kusunthika kwa chopondacho ndikotheka, koma popanda kutsegula m'mimba. Izi sizimabweretsa ngozi.

Kodi ndingatenge metformin popanda kufunsa dokotala?

Mankhwala a Metformin amagawidwa ku mankhwala osokoneza bongo popanda mankhwala, kotero munthu amatha kuwagula osayendera dokotala kale. Musanayambe kugwiritsa ntchito mankhwalawa, muyenera kuwonetsetsa kuti wodwala alibe zotsutsana ndi ntchito yake. Ndikwabwino kuyezetsa magazi. Ikuwunika momwe chiwindi ndi impso zimayendera. Kuyesedwa koteroko kumayenera kuchitika kamodzi kamodzi m'miyezi 6. Ndikofunikanso kuwongolera kuchuluka kwa cholesterol m'magazi komanso kuchuluka kwa kuthamanga kwa magazi, zomwe zimapangitsa kuti pakhale zovuta zodwala zamtima.

Mlingo wa metformin wokwanira tsiku ndi tsiku ndi zingati?

Onse ochepetsa thupi komanso pochiza matenda amtundu wa 2 wodwala, wodwalayo amapatsidwa 2550 mg ya metformin tsiku lililonse. Pankhaniyi, munthu ayenera kumwa mapiritsi atatu a mankhwalawa katatu patsiku. Mlingo wa mankhwalawa ndi 850 mg.

Ngati mankhwala omwe atulutsidwa nthawi yayitali atagwiritsidwa ntchito pochiza, ndiye kuti mlingo wambiri tsiku lililonse ndi 2000 mg. Kuti muchite izi, imwani mapiritsi 4 a 500 mg a mankhwala Glucofage kale musanagone.

Mlingo woyamba wa mankhwalawa ukhale wocheperako: 500 kapena 850 mg. Kenako, kutsatira momwe thupi limagwirira ntchito, mlingo wake umayamba kuwonjezeka. Kuyenda pang'onopang'ono kumalepheretsa kukula kwa zovuta m'mimba.

Ngati munthu angaganize kutenga metformin kuti achepetse moyo wobwera, ndikulimbikitsidwa kusunga mlingo wa 500-1700 mg patsiku, koma osatinso.

Kodi zotsatira zake zimatenga nthawi yayitali bwanji?

Metformin yokhala ndi nthawi yayitali imagwira ntchito kwa maola 8-9. Mapiritsi a metformin amchikhalidwe amakhalabe ndi zotsatira zosaposa maola 6. Ngati mlingo wotsatira watengedwa kumwa mankhwala asanachitike, musadandaule. Sizowononga thanzi. Ndikofunika kuonetsetsa kuti palibe mankhwala osokoneza bongo omwe amachitika. Pachifukwa ichi, mankhwalawa sayenera kumwedwa mopitirira muyeso wa tsiku lililonse.

Kodi metformin ikhoza kuphatikizidwa ndi ma statins?

Metformin imatha kutengedwa ndi ma statins, omwe amathandiza kuchepa kwa mafuta m'thupi. Ngati nthawi yomweyo munthu amatsatira zakudya, ndiye kuti zidzakhala zotheka kuti asamangokhala cholesterol, komanso triglycerides, komanso mgwirizano wa atherogenicity. Komanso, kudya metformin ndikudya chakudya kwakanthawi kumatha kukuthandizani kuti mupewe kupuma. Menyu wokhala ndi zopatsa mphamvu zamagalimoto ambiri umakupatsani mwayi kuti muchotse madzi ochulukirapo m'thupi, muchotse edema, komanso muchepetse magazi. Chifukwa chake, madokotala amalimbikitsa pang'onopang'ono kuchepetsa Mlingo wa mankhwalawa zochizira mtima, kenako mutha kuzisiyiratu. Ndizotheka kuti zitha kuyimitsa mankhwalawa ndi mankhwala okodzetsa.

Kodi metformin ikhoza kuphatikizidwa ndi mowa?

Mankhwalawa ndi mankhwala a metformin, ndizovomerezeka kugwiritsa ntchito milingo yaying'ono ya mowa. Komabe, muyenera kuyang'anira kuchuluka kwa mowa womwe umamwa, sikuletsedwa kuledzera.

Palibe chifukwa chokhazikitsira pakati pakumwa mankhwala kapena kumwa mowa. Ndiye kuti, mumatha kumwa mowa nthawi yomweyo.

Ngati simumayang'anira kumwa ndi kumwa kwambiri mowa, ndiye kuti kwa odwala matenda ashuga izi zikuwopseza kukula kwa lactic acidosis. Ili ndi vuto lalikulu lomwe lingayambitse imfa. Chifukwa chake, uchidakwa umakhala wowopsa thanzi.