Humulin® M3 (Humulin® M3)

Dzina la malonda akukonzekera: HUMULIN ® Nthawi zonse

Dzinalo Losagwirizana Ndi Mayiko Onse (INN):
Soluble insulin (umisiri wa majini a anthu)

Mlingo
Yankho la jakisoni

Kupanga
1 ml muli:
ntchito yogwira - insulin yaumunthu 100 IU / ml,
zokopa: metacresol, glycerol (glycerin), madzi a jakisoni, hydrochloric acid solution 10% ndi / kapena sodium hydroxide solution 10% angagwiritsidwe ntchito popanga njira yokhazikitsira pH.

Kufotokozera
Njira yopanda mawonekedwe.

Gulu la Pharmacotherapeutic
Wothandizirana ndi hypoglycemic ndi insulin yochepa.

Nambala ya ATX A10AB01.

Mankhwala
Mankhwala
Humulin ® pafupipafupi ndimapangidwe amtundu wa DNA insulin. Chochita chachikulu cha insulin ndi kuphatikiza shuga kagayidwe. Kuphatikiza apo, imakhala ndi anabolic komanso anti-catabolic zotsatira zake zosiyanasiyana zamthupi. Mu minofu ya minofu, pali kuchuluka kwa glycogen, mafuta acid, glycerol, kuchuluka kwa mapuloteni komanso kuwonjezereka kwa kumwa ma amino acid, koma nthawi yomweyo kumachepa mu glycogenolysis, gluconeogeneis, ketogenesis, lipolysis, proteinabolism ndi kutulutsidwa kwa ma amino acid.
Humulin ® pafupipafupi ndikulinganiza kwakanthaŵi kwa insulin. Kukhazikika kwa mankhwalawa ndi mphindi 30 pambuyo pa kuperekedwa, mphamvu yayikulu imakhala pakati pa 1 ndi maola 3, kutalika kwa nthawi ndi maola 5-7. Kusiyana kwamwini pantchito ya insulin kumadalira zinthu monga mlingo, kusankha jakisoni, malo olimbitsa thupi, ndi zina zambiri.

Pharmacokinetics
Kukwanira kwathunthu ndi kuyambika kwa mphamvu ya insulin kumadalira malo a jakisoni (m'mimba, ntchafu, matako), mlingo (kuchuluka kwa insulin), kuchuluka kwa insulin, mankhwalawa. Amawonongedwa ndi insulinase makamaka m'chiwindi ndi impso. Amachotsa impso (30-80%).

Gulu la Nosological (ICD-10)

Mlingo ndi makonzedwe

S / c phewa, ntchafu, matako kapena pamimba. Kuwongolera kwa mnofu kumaloledwa.

Mlingo wa Humulin ® M3 umatsimikiziridwa ndi dokotala aliyense payekha, kutengera kuchuluka kwa shuga m'magazi. Mu / kumayambiriro kwa mankhwala a Humulin M3 amatsutsana.

Kutentha kwa mankhwala omwe amaperekedwa kuyenera kukhala kutentha kwambiri. Masamba a jakisoni ayenera kusinthidwa kuti malo omwewo sawagwiritsanso ntchito mwina kamodzi pamwezi. Ndi s / c makonzedwe a insulini, chisamaliro chimayenera kutengedwa kuti musalowe mumtsempha wamagazi. Pambuyo pa jakisoni, tsamba la jakisidwe siliyenera kutenthedwa.

Odwala ayenera kuphunzitsidwa bwino kugwiritsa ntchito insulin yobereka.

Humulin ® M3 ndi msanganizo wopangidwa wokonzeka wokhala ndi mawonekedwe ena a Humulin ® Wokhazikika ndi Humulin ® NPH, wokonzedwa kuti apewe kufunika kophatikizira kukonzekera kwa insulin ndi odwala omwe. Ndondomeko ya insulin makonzedwe ali payekha.

Kukonzekera mawu oyamba

Kukonzekera Humulin ® M3 mu mbale. Musanagwiritse ntchito, Mbale za Humulin ® M3 zizigundidwa kangapo mpaka insulini itayambanso kupangika mpaka ikhale yunifolomu yamadzi kapena mkaka. Gwedezani mwamphamvu, monga izi zimatha kuyambitsa foam, zomwe zingasokoneze mlingo woyenera. Osagwiritsa ntchito insulini ngati ili ndi flakes mutasakaniza kapena tinthu tating'ono tomwe timatirira pansi kapena makhoma a vial, ndikupanga mawonekedwe a frosty. Gwiritsani ntchito syringe ya insulin yomwe ikufanana ndi kuchuluka kwa insulin.

Zokonzekera Humulin ® M3 m'makalata. Musanagwiritse ntchito, makatiriji a Humulin ® M3 amayenera kukukhidwira pakati pama manja khumi ndikugwedezeka, kutembenuka kwa 180 ° komanso khumi mpaka insuliniyo itatsitsimuka kwathunthu mpaka itakhala yunifolomu yamadzi kapena mkaka. Gwedezani mwamphamvu, monga izi zimatha kuyambitsa foam, zomwe zingasokoneze mlingo woyenera. Mkati mwa bokosi lirilonse pali galasi yaying'ono yagalasi yomwe imathandizira kusakanikirana kwa insulin. Musagwiritse ntchito insulini ngati ili ndi mapokoso mukasakaniza. Chipangizo cha ma cartridge sichimalola kusakanikirana ndi zomwe zili ndi insulini zina mwachindunji mu cartridge lokha. Makatoniwo sanapangidwe kuti adzazitsidwe. Pamaso pa jekeseni, ndikofunikira kuti mudziwe bwino malangizo a wopanga kuti mugwiritse ntchito cholembera kuti mupeze insulin.

Kwa Humulin ® M3 mu cholembera cha QuickPen ™ Syringe. Pamaso jakisoni, muyenera kuwerenga Malangizo a QuickPen ™ Syringe pen Instruction.

QuickPen ™ Syringe chole Guide

QuickPen ™ Syringe chole ndi yosavuta kugwiritsa ntchito. Ndi chipangizo chothandizira kuperekera insulini ("insulin cholembera)" yomwe ili ndi 3 ml (300 PIECES) pakukonzekera kwa insulin ndi ntchito ya 100 IU / ml. Mutha kulowa kuchokera ku 1 mpaka 60 ya insulin pa jakisoni. Mutha kukhazikitsa mlingo molondola ndi umodzi. Ngati mayunitsi ambiri akhazikitsidwa, mlingowo ungakonzedwe popanda kutaya insulin. QuickPen ™ Syringe chole ikulimbikitsidwa kuti izigwiritsidwa ntchito ndi singano zopangira Becton, Dickinson ndi Company (BD) zolembera ma syringe. Musanagwiritse ntchito cholembera, onetsetsani kuti singanoyo imalumikizidwa kwathunthu ndi cholembera.

M'tsogolo, malamulo otsatirawa akuyenera kutsatiridwa.

1. Tsatirani malamulo a asepsis ndi antiseptics omwe adokotala amuuzani.

3. Sankhani malo pobayira.

4. Pukuta khungu pamalo opaka jekeseni.

5. Masamba obayira enanso kuti malo omwewo sawagwiritsanso ntchito kamodzi pamwezi.

Kukonzekera ndi Kuyambitsa QuickPen ™ Syringe cholembera

1. Kokani chipewa cha cholembera kuti muchotse. Osazungulira kapu. Osachotsa cholembera ku cholembera. Onetsetsani kuti insulin imayang'ana mtundu wa insulin, tsiku lotha ntchito, mawonekedwe. Pukutani pang'onopang'ono cholembera kakhumi pakati pa kanjedza ndikutembenuka kangapo.

2. Tengani singano yatsopano. Chotsani chomata papepala lakunja kwa singano. Gwiritsani ntchito swab ya mowa kupukuta disc ya mphira kumapeto kwa cholembera. Gomerani singano yomwe ili mu chipewa, makamaka, ku cholembera. Skani pa singano kufikira mutalumikizidwa kwathunthu.

3. Chotsani kapu yakunja kuchokera singano. Osataya. Chotsani thumba lamkati la singano ndikuitaya.

4. Chongani cholembera cha QuickPen ™ Syringe cholembera. Nthawi iliyonse muyenera kuwunika insulin. Chitsimikizo cha kutulutsidwa kwa insulini kuchokera ku cholembera kuti chichitike jekeseni iliyonse isanafike pang'onopang'ono mpaka inshuwaransi ikawonekere kuonetsetsa kuti cholembera chakonzeka.

Ngati simukuyang'ana insulin, musanayambe kudwala, mutha kupeza insulin yochepa kwambiri kapena yambiri.

5. Konzani khungu pakukoka kapena kulisonkhanitsa mu khola lalikulu. Ikani singano ya sc pogwiritsa ntchito jekeseni yemwe dokotala wanu wakupatsani. Ikani chala chanu pa batani la mlingo ndikusindikiza mwamphamvu mpaka chitayima kwathunthu. Kuti mulowetse mlingo wathunthu, gwiritsani batani la mlingo ndikuwerengerani pang'onopang'ono mpaka 5.

6. Chotsani singano ndikufinya pang'onopang'ono malo a jakisoni ndi swab ya thonje kwa masekondi angapo. Osatupa malo a jakisoni. Ngati insulin ikung'ambika kuchokera singano, nthawi zambiri wodwalayo sanagwiritse singano pansi pakhungu kwanthawi yayitali. Kukhalapo kwa dontho la insulin pamsana pa singano ndikwabwinobwino, sikukhudza mlingo.

7. Pogwiritsa ntchito singano, inaninso singano ndikuitaya.

Ngakhale manambala amasindikizidwa muwindo la chizindikiro ngati manambala, manambala osamvetseka ngati mizere yolunjika pakati pa manambala.

Ngati mlingo wofunikira pakumuyendetsa uposa kuchuluka kwa zigawo zomwe zatsalira mu cartridge, mutha kuyika kuchuluka kwa insulini mu cholembera ichi ndipo mugwiritse ntchito cholembera chatsopano kuti mumalize muyeso wofunikira, kapena lembani mlingo wonse pogwiritsa ntchito cholembera chatsopano.

Osayesa kubaya insulin potembenuza batani la mlingo. Wodwala sadzalandira insulin ngati atembenuza batani la mlingo. Muyenera kuwonekera pa batani la mlingo molunjika kuti mulandire insulin.

Musayese kusintha mlingo wa insulin panthawi ya jakisoni.

Zindikirani Cholembera sichingalole kuti wodwalayo akhazikitse muyeso wa insulin mopitirira muyeso wa zigawo zomwe zatsala mu cholembera. Ngati mulibe chitsimikizo kuti mlingo wathunthu waperekedwa, simuyenera kulowa wina. Ndikofunikira kuchotsa singano pambuyo pa jekeseni iliyonse. Muyenera kuwerengera ndikutsatira malangizo omwe akupezeka mu malangizo ogwiritsira ntchito mankhwalawa. Ndikofunikira kuyang'ana cholembera pa cholembera asanalowe aliyense jakisoni, kuonetsetsa kuti tsiku lotha ntchito latha ndipo wodwalayo akugwiritsa ntchito mtundu woyenera wa insulin, osachotsa chizindikiro pa cholembera.

Mtundu wa batani la syringe cholembera wa QuickPick ™ ulingana ndi mtundu wa Mzere pa cholembera cholembera ndipo zimatengera mtundu wa insulin. Mu buku ili, batani la mlingo limayimitsidwa. Mtundu wa beige wa cholembera cha syringe wa QuickPen ™ umawonetsera kuti umapangidwa kuti ugwiritse ntchito ndi zinthu za Humulin ®.

Kusunga ndi kutaya

Cholembera sichitha kugwiritsidwa ntchito ngati chakhala kunja kwa firiji kwa nthawi yochulukirapo kuposa yomwe idafotokozedwa m'mayendedwe ogwiritsa ntchito.

Osasunga cholembera ndi singano yake. Ngati singanoyo yatsala kuti ikanikizidwe, insulansi ingatuluke m'timalo, kapena insulin ikhoza kupukuta mkati mwa singano, potseka singano, kapena thovu la mpweya lingalowe mkati mwa katoni.

Ma cholembera a syringe omwe sagwiritsidwa ntchito ayenera kusungidwa mufiriji kutentha kwa 2 mpaka 8 ° C. Osagwiritsa ntchito cholembera kuti chitauma.

Chingwe chomwe chagwiritsidwa ntchito pakadali pano chizisungidwa kutentha, m'malo otetezedwa ndi kutentha ndi kuwala, kwa ana.

Chotsani singano zogwiritsidwa ntchito polemba-maumboni, zopangira zofananira (mwachitsanzo, zotengera zama biohazardous zvinhu kapena zinyalala), kapena monga momwe katswiri wanu wazachipatala adakulimbikitsira.

Tayani chimbudzi chogwiritsa ntchito sindingagwiritse ntchito ndi singano malinga ndi malangizo a dotolo wothandizila malinga ndi zofunikila zotaya zinyalala zakuchipatala.

Osabwezanso zotengera zazitali.

Kutulutsa Fomu

Kuyimitsidwa kwa kayendetsedwe ka subcutaneous, 100 IU / ml. 10 ml ya mankhwalawa osalowa mugalasi Mbale. 1 fl. kuyikidwa mu paketi ya kadikhadi.

3 ml iliyonse kapu yolowerera ndale. Makatoni 5 amaikidwa pachimake. 1 bl. zimayikidwa pabokosi lamakatoni kapena makatoni amaikidwa mu cholembera cha syringe ya QuickPen ™. Ma cholembera asanu a syringe amaikidwa pakatoni.

Wopanga

Yopangidwa ndi: Eli Lilly ndi Company, USA. Lilly Corporate Center, Indianapolis, Indiana 46285, USA.

Atanyamula: ZAO "ORTAT", 157092, Russia, dera la Kostroma, chigawo cha Susaninsky, s. Kumpoto, microdistrict. Kharitonovo.

Cartridges, QuickPen ™ Syringe Pens , yopangidwa ndi Lilly France, France. Zone Industrialiel, 2 ru Colonel Lilly, 67640 Fegersheim, France.

Atanyamula: ZAO "ORTAT", 157092, Russia, dera la Kostroma, chigawo cha Susaninsky, s. Kumpoto, microdistrict. Kharitonovo.

Lilly Pharma LLC ndiye mlendo yekha wa Humulin ® M3 ku Russia Federation

Zotsatira za pharmacological

Munthu wobwerezabweretsanso insulin ya DNA. Ndi kukonzekera kwa insulin.
Choyambitsa chachikulu cha mankhwalawa ndi kuyamwa kwa kagayidwe kazakudya. Kuphatikiza apo, ili ndi anabolic zotsatira. Mu minofu ndi minyewa ina (kupatula ubongo), insulin imayendetsa mofulumira intracellular ya glucose ndi amino acid, imathandizira protein anabolism. Insulin imalimbikitsa kutembenuka kwa glucose kukhala glycogen m'chiwindi, kumalepheretsa gluconeogeneis ndikuthandizira kusintha kwa glucose owonjezera kukhala mafuta.

Zotsatira zoyipa

- Zotsatira zoyipa zomwe zimakhudzana ndi zotsatira zazikulu za mankhwala: hypoglycemia.
- Hypoglycemia yayikulu imatha kutha kwa chikumbumtima ndipo (mwapadera) mpaka kufa.
- Zotsatira zoyipa: Matenda a m'deralo amatha - kukhumudwa, kutupa kapena kuyabwa pamalo opangira jakisoni (nthawi zambiri amayimitsa pakadutsa masiku angapo mpaka masabata angapo), zimachitika mwatsatanetsatane (zimachitika kangapo, koma zimakhala zowopsa) - kuyamwa kokhazikika, kufupika, kupuma movutikira, kutsika magazi, kuchuluka kwa mtima, kuchuluka thukuta. Milandu yambiri yokhudzana ndimomwe thupi limagwirira ntchito ikhoza kukhala pachiwopsezo cha moyo.
- Zina: mwayi wokhala ndi lipodystrophy ndizochepa.

Mlingo

Kuyimitsidwa kwa jakisoni 100 IU / ml

Mlingo umodzi wa kuyimitsidwa uli ndi

ntchito yogwira - insulin ya anthu (DNA - recombinant) 100 IU,

obwera: metasedresol yosungunuka, glycerin, phenol, protamine sulfate, sodium hydrogen phosphate heptahydrate, zinc oxide (malinga ndi Zn ++ zinc), hydrochloric acid 10% kusintha pH, sodium hydroxide 10% yothetsera kusintha pH, madzi a jakisoni.

Kuyimitsidwa koyera, komwe, kuyimilira, kumakhala exxpatant yowoneka bwino, yopanda utoto kapena mawonekedwe oyera. Mtengo umasinthidwa mosavuta ndikugwedezeka modekha.

Mankhwala

Pharmacokinetics

Humulin® M3 ndiakonzekereratu. Kukhazikika kwa mankhwala ndi mphindi 30 pambuyo pa kuperekedwa, mphamvu yayikulu imakhala pakati pa 1 ndi 8.5 maola, nthawi ya kuchitapo ndi maola 14-15.

Chithunzi chojambulidwa (glucose uptake curve) pambuyo pa kayendetsedwe ka subcutaneous chikuwonetsedwa ngati mzere wolimba mtima pach chithunzi chomwe chili pansipa. Kusiyana kwamwini pantchito ya insulin kumadalira zinthu monga mlingo, kusankha jakisoni, malo olimbitsa thupi, ndi zina zambiri.

Ntchito ya insulin

Nthawi (maola)

Mankhwala

Humulin M3 ndi mtundu wina wa insulin wa DNA. Ndi kuyimitsidwa kawiri kwa jakisoni (30% Humulin Х Nthawi zonse ndi 70% Humulin NPH).

Chochita chachikulu cha insulin ndi kuphatikiza shuga kagayidwe.

Kuphatikiza apo, imakhala ndi anabolic komanso anti-catabolic zotsatira zosiyanasiyana zamthupi. Mu minofu ya minofu, pali kuchuluka kwa glycogen, mafuta acid, glycerol, kuchuluka kwa mapuloteni komanso kuwonjezereka kwa kumwa ma amino acid, koma nthawi yomweyo kumachepa mu glycogenolysis, gluconeogeneis, ketogenesis, lipolysis, proteinabolism ndi kutulutsidwa kwa ma amino acid.