Siofor: malangizo ogwiritsira ntchito, mtengo, ndemanga, mapiritsi

Munkhaniyi, mutha kuwerengera malangizo ogwiritsira ntchito mankhwalawa Siofor. Amapereka ndemanga kuchokera kwa alendo omwe amabwera patsamba lino - ogula mankhwalawa, komanso malingaliro a akatswiri azachipatala pakugwiritsa ntchito Siofor pochita. Chopempha chachikulu ndikuti muwonjezere ndemanga zanu za mankhwalawa: mankhwalawo adathandizira kapena sanathandizire kuchotsa matendawa, ndizovuta ziti zomwe zimawoneka ndi zotsatirapo zake, zomwe mwina sizinalengezedwe ndi wopanga. Ma analogi a Siofor pamapezeka ma analogues omwe amapezeka. Gwiritsani ntchito pochizira matenda amishuga amtundu wa 2 komanso kunenepa kwambiri (okonda kuchepa thupi) mwa akulu, ana, komanso pa nthawi ya bere. The zikuchokera ndi mogwirizana ndi mankhwala ndi mowa.

Siofor - mankhwala a hypoglycemic ochokera pagulu la Biguanide. Amapereka kuchepa kwa magulu oyambira a glucose oyambira komanso a postprandial. Simalimbikitsa kubisalira kwa insulin chifukwa chake sikumabweretsa hypoglycemia. Zochita za metformin (zomwe zimagwiritsidwa ntchito ndi mankhwala a Siofor) mwina zimatengera njira zotsatirazi:

• kuchepa kwa shuga m'magazi chifukwa cha kuletsa kwa gluconeogeneis ndi glycogenolysis,
• kukulitsa chidwi cha minofu ku insulin, motero, kukonza zotumphukira zamafuta ndikugwiritsira ntchito,
• kuletsa kwamatumbo shuga.

Siofor kudzera mu zochita zake pa glycogen synthetase imapangitsa kaphatikizidwe ka glycogen. Zimawonjezera kuthekera kwamapuloteni onse a glucose membrane onyamula mpaka pano.

Mosasamala kanthu zazomwe zimachitika ndi glucose wamagazi, zimakhala ndi phindu pa metabolidi ya lipid, zomwe zimapangitsa kutsika kwa cholesterol yathunthu, cholesterol yotsika kwambiri komanso triglycerides.

Kupanga

Metformin hydrochloride + Excipients.

Pharmacokinetics

Mukamadya, mayamwidwe amachepetsa ndipo pang'onopang'ono amachepetsa. Mtheradi wa bioavailability mu odwala athanzi ndi pafupifupi 50-60%. Sizikugwirizana ndi mapuloteni a plasma. Amayamwa mkodzo osasinthika.

Zizindikiro

• lembani matenda ashuga a 2 a shuga (osagwirizana ndi insulin), makamaka kuphatikiza kunenepa kwambiri ndi mankhwala osagwira ntchito pakudya.

Kutulutsa Mafomu

Mapiritsi okhala ndi 500 mg, 850 mg ndi 1000 mg.

Malangizo ogwiritsira ntchito ndi regimen

Mlingo wa mankhwalawa umayikidwa payekha kutengera kuchuluka kwa shuga m'magazi. Mankhwalawa akuyenera kuchitika ndi kuwonjezeka kwapang'onopang'ono kwa mlingo, kuyambira ndi 0,5-1 g (mapiritsi 1-2) a Siofor 500 kapena 850 mg (piritsi 1) la Siofor 850. Kenako, kutengera kuchuluka kwa glucose m'magazi, mlingo wa mankhwalawa umachulukitsidwa pakadutsa nthawi yayitali Sabata 1 pamaso pa pafupifupi tsiku lililonse la 1.5 g (mapiritsi atatu) a Siofor 500 kapena 1.7 g (mapiritsi 2) a Siofor 850. Mulingo wambiri tsiku lililonse wa Siofor 500 ndi 3 g (mapiritsi 6), Siofor 850 ndi 2.55 g (mapiritsi atatu) .

Wapakati tsiku lililonse la Siofor 1000 ndi 2 g (mapiritsi 2). Mlingo wapamwamba wa tsiku lililonse wa Siofor 1000 ndi 3 g (mapiritsi atatu).

Mankhwalawa amayenera kumwedwa pakudya, osafuna kutafuna, kumwa madzi ambiri.

Ngati mlingo wa tsiku ndi tsiku wa mankhwala woposa piritsi limodzi, uyenera kugawidwa pawiri. Kutalika kwa kugwiritsa ntchito kwa mankhwala a Siofor amatsimikiza ndi dokotala.

Mankhwala omwe amusowa sayenera kulipidwa ndi mlingo umodzi wa mapiritsi akuluakulu ofanana.

Chifukwa chowonjezera chiopsezo cha lactic acidosis, mlingo uyenera kuchepetsedwa ngati mavuto azovuta a metabolic.

Zotsatira zoyipa

• kusanza, kusanza,
• kulawa kwazitsulo mkamwa
• kusowa kwa chakudya
• kutsegula m'mimba
• chisangalalo
• kupweteka m'mimba
• munthawi zina (ndi mankhwala osokoneza bongo, pamaso pa matenda omwe kugwiritsa ntchito mankhwalawa akuphwanya, ndi uchidakwa), lactic acidosis ingayambike (imafuna kusiya kwa mankhwalawa),
• Ndi chithandizo chotalika, kupanga B12 hypovitaminosis (malabsorption) ndikotheka,
• anemia yam'magazi,
• hypoglycemia (kuphwanya njira yeniyeni),
• zotupa pakhungu.

Contraindication

• mtundu 1 shuga
• kuchotsa kwathunthu kwa kulowa kwa insulin m'thupi ndi matenda a shuga a 2,
• matenda ashuga ketoacidosis, matenda a shuga, chikomokere,
• chiwindi ndi / kapena impso ntchito,
• myocardial infaration
• kulephera kwa mtima
• kusowa kwamadzi
• matenda oopsa a m'mapapo ndi kulephera kupuma,
• matenda opatsirana opatsirana
• ntchito, kuvulala,
• nyengo yamatumbo (machitidwe omwe ali ndi njira zowola zowonongeka, mwachitsanzo, ngati pali zotupa zamatenda),
• machitidwe a hypoxic
• uchidakwa wambiri,
• lactic acidosis (kuphatikizapo mbiri),
• mimba
• mkaka wa m'mawere (yoyamwitsa),
• kutsatira zakudya zomwe zili ndi malire a chakudya chopatsa mphamvu (zosakwana 1000 kcal patsiku),
• zaka za ana
• gwiritsani ntchito kwa maola 48 kapena kucheperapo isanachitike komanso mkati mwa maola 48 mutapanga maphunziro a radioisotope kapena x-ray ndikukhazikitsa njira yokhala ndi ayodini (Siofor 1000),
• Hypersensitivity pamagawo a mankhwala.

Mimba komanso kuyamwa

Mankhwalawa amatsutsana kuti agwiritse ntchito panthawi yoyembekezera komanso panthawi yoyamwitsa (yoyamwitsa).

Malangizo apadera

Musanafotokozere mankhwala, komanso miyezi isanu ndi umodzi, ndikofunikira kuwunika ntchito ya chiwindi ndi impso.

Ndikofunikira kuyendetsa mulingo wa lactate m'magazi osachepera 2 pachaka.

Njira ya mankhwalawa ndi Siofor 500 ndi Siofor 850 ayenera kuthandizidwa ndi mankhwala ena a hypoglycemic (mwachitsanzo, insulin) masiku 2 asanafike pakuwunika kwa X-ray ndi kuyamwa kwa ayodini, komanso masiku awiri asanagwidwe opaleshoni yayikulu Patatha masiku awiri atamuyeza kapena atamuchita opaleshoni.

Kuphatikiza mankhwala ndi sulfonylureas, kuwunika mosamala kuchuluka kwa shuga m'magazi ndikofunikira.

Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu

Mukamagwiritsa ntchito Siofor, sizikulimbikitsidwa kuti muzichita zinthu zomwe zimafunikira chidwi komanso kuthamanga kwa psychomotor chifukwa choopsa cha hypoglycemia.

Kuyanjana kwa mankhwala

Pogwiritsa ntchito munthawi yomweyo ndi mankhwala a sulfonylurea, acarbose, insulin, mankhwala osokoneza bongo a anti-yotupa (NSAIDs), ma inhibitors a MAO, oxytetracycline, ACE inhibitors, exofibrate, zotumphukira za cyclophosphamide, beta-adrenergic blocker.

Pogwiritsa ntchito munthawi yomweyo ndi glucocorticosteroids (GCS), njira zakulera zam'mlomo, epinephrine, sympathomimetics, glucagon, mahomoni a chithokomiro, zotumphukira zakuchokera kwa nicotinic acid, ndizotheka kuchepetsa zotsatira za hypoglycemic za Siofor.

Siofor imatha kufooketsa zotsatira za anticoagulants.

Pogwiritsa ntchito munthawi yomweyo ndi ethanol (mowa), chiopsezo cha lactic acidosis chimawonjezeka.

Nifedipine imawonjezera mayamwidwe ndi mulingo wa metformin m'madzi a m'magazi, imathandizira kuthetsedwa kwake.

Mankhwala a Cationic (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren, vancomycin) omwe amatulutsidwa m'mapikisano olimbana ndi machitidwe oyendetsa ma tubular ndipo, akakhala ndi chithandizo chambiri, amatha kukulitsa kuchuluka kwa metformin m'magazi am'magazi.

Cimetidine amachepetsa kuchotsedwa kwa Siofor, komwe kumawonjezera chiopsezo cha lactic acidosis.

Analogs a mankhwala Siofor

Zofanana muzochitika zamagulu:

• Bagomet,
• Glycon
• Glyminfor,
• Glyformin
• Chikwanje,
• Glucophage Long,
• Langerine
• Methadiene
• Metospanin
• Metfogamma 1000,
• Metfogamma 500,
• Metfogamma 850,
• Metformin
• Metformin hydrochloride,
• Nova Met
• NovoFormin,
• Siofor 1000,
• Siofor 500,
• Siofor 850,
• Sofamet
• Fomu,
• Forin Pliva.

Zotsatira za pharmacological

Siofor ndi mankhwala a hypoglycemic omwe ali m'gululi khwawa. Mankhwalawa ali ndi vuto la antiidiabetes. Zimathandizira kuletsa kuyamwa kwa glucose m'matumbo am'mimba, kumakulitsa chidwi cha insulini m'matumba otumphukira, ndikuchepetsa njirayi glucogeneis. Mothandizidwa ndi mankhwalawa, kugwiritsira ntchito shuga kwa minofu imayatsidwa. Siofor imathandizanso kagayidwe ka lipid chifukwa cha kutsitsa kwa lipid komanso pazinthu zowundana chifukwa cha zotsatira za fibrinolytic.

Mankhwalawa amachepetsa shuga m'magazi, amathandizira kuchepetsa thupi mwa anthu omwe akudwala matenda ashugaamachepetsa chilako.

Pharmacodynamics ndi pharmacokinetics

Pazitali kwambiri ya mankhwalawa imatheka patatha maola 2,5 kuchokera pakamwa. Ngati chakudya chimatengedwa nthawi yomweyo monga mankhwalawa, kuyamwa kumachepa ndikuchepa. Mwa anthu athanzi, bioavailability pafupifupi 50-60%.

Zomwe zimagwiritsidwa ntchito pafupifupi sizikugwirizana ndi mapuloteni a plasma.

Kuchoka kwa mankhwalawa kumachitika mosasinthika mkodzo. Hafu ya moyo pambuyo mkamwa makonzedwe ndi pafupifupi 6.5 maola.

Ngati wodwala wachepetsa impso, kutsitsa hafu ya moyo kumawonjezeka, chifukwa chake, kuphatikizidwa kwa plasma kumawonjezeka metformin.

Contraindication

Contraindication potenga mankhwalawa ndi awa:

• Hypersensitivity
• matenda ashugachoyambirira,
• matenda ashuga ketoacidosis,
• matenda a shuga, chikomokere,
• kusiya kwa amkati insulin katulutsidwe mwa odwala a mtundu 2 matenda oopsa,
• aimpso, chiwindi, kulephera kupuma,
• myocardial infaration pachimake,
• matenda opatsirana opatsirana
• kuvulala ndi maopareshoni
• machitidwe a hypoxic
• njira zowola zowonongeka mthupi (zotupa, ndi zina),
• lactic acidosis,
• uchidakwa wambiri,
• chakudya okhala ndi zopatsa mphamvu zochepa (zosakwana ma calories 1000 patsiku),
• zaka za ana
• nthawi ya pakati, yoyamwitsa.

Zotsatira zoyipa

Mukamamwa Siofor, zotsatirazi ndizotheka:

• Pazigawo zam'mimba: kumayambiriro kwa chithandizo, pamatha kukomoka zachitsulo pakamwa, kuchepa kwa chilala, kusanza, kupweteka pamimba, kutsekula m'mimba. Mankhwalawa, zotsatirazi zimayamba kutha.
• Mu hematopoietic dongosolo: silingathe kukhala megaloblastic anemia.
• Khungu: nthawi zina, khazikani thupi lawo siligwirizana.
• Nthawi zina, mawonetseredwe amatha lactic acidosis.

Malangizo a Siofor (Njira ndi Mlingo)

Nthawi zambiri, mapiritsi amatengedwa pakamwa, amayenera kutsukidwa ndi madzi ambiri, osatafuna. Mlingowo umaperekedwa ndi adotolo kutengera kuchuluka kwa shuga omwe amapezeka mwa wodwala.

Malangizo pa Siofor 500 zotsatirazi: koyambirira mapiritsi 1-2 amatchulidwa patsiku, pang'onopang'ono mlingo wa tsiku ndi tsiku umakulitsidwa ndi mapiritsi atatu. Mlingo waukulu kwambiri wa mankhwalawa patsiku ndi mapiritsi asanu ndi limodzi. Ngati munthu amatenga piritsi limodzi patsiku, ndikofunikira kuti muwagawike muyezo waukulu. Simungathe kuwonjezera mlingo popanda kufunsa kaye dokotala. Kutalika kwa chithandizo kumayikidwa kokha ndi katswiri.

Malangizo ogwiritsira ntchito Siofora 850 chotsatira: poyamba, mankhwalawa amayamba piritsi limodzi. Pang'onopang'ono, mlingo umatha kuwonjezeka mpaka mapiritsi awiri. Simungatenge mapiritsi oposa 3 patsiku. Ngati piritsi limodzi limatengedwa patsiku, muyenera kuwagawa m'magawo angapo. Simungathe kuwonjezera mlingo popanda kufunsa kaye dokotala. Kutalika kwa chithandizo kumatsimikiziridwa ndi katswiri.

Malangizo pa Siofor 1000 Otsatirawa: kudya kumayambira piritsi limodzi, palibe mapiritsi atatu kuposa omwe angathe kumwa tsiku lililonse. Nthawi zina ndikofunikira kuphatikiza kumwa mankhwalawa ndi insulin. Simungagwiritse ntchito Siofor kuti muchepetse thupi musanapume kaye ndi dokotala.

Kumwa mankhwala polycystic ovary Zimatheka pokhapokha kuvomerezedwa ndi dokotala.

Bongo

Mukamachita kafukufuku sanawonedwe hypoglycemia ngakhale mlingo wopitilira tsiku lililonse katatu. Kugwiritsa ntchito mopitirira muyeso kumatha lactic acidosis. Zizindikiro za izi ndi kusanza, kutsegula m'mimba, kufooka, kupuma pafupipafupi, kulephera kudziwa. Potere, hemodialysis imachitidwa. Koma nthawi zambiri kuchotsedwa kwa zizindikiro kumalola kugwiritsa ntchito shuga kapena shuga.

Kuchita

Ngati Siofor amatengedwa nthawi yomweyo ndimankhwala ena ochepetsa shuga, NSAIDs, Mao inhibitors, ma fibrate, ACE inhibitors, insulin, ndikofunikira kuyang'anitsitsa mosamala komanso pafupipafupi kuchuluka kwa shuga. Potere, ma hypoglycemic amatha a Siofor akhoza kuchuluka.

Kugwiritsa ntchito bwino kwa mankhwalawa kumatha kuchepa ngati atengedwa limodzi ndi mahomoni a chithokomiro, glucocorticosteroids, progesterone, estrogenthiazide diuretics sympathomimetics, komanso nicotinic acid. Pankhaniyi, ndikofunikira kuwongolera kuchuluka kwa glycemia, kusintha kwa Siofor ndikotheka.

Chithandizo cha munthawi yomweyo cimetidine zitha kukulitsa mwayi wowonekera lactic acidosis.

Malangizo apadera

Munthawi ya chithandizo ndi mankhwalawa, ndikofunikira kuyang'anitsitsa magwiridwe antchito a impso za wodwalayo.

Ngati kuyezetsa kwa radiology, mankhwalawo amayenera kuyimitsidwa musanayesedwe ndipo musamwe mankhwalawo masiku ena awiri atangoyeserera, popeza kuyambitsa kusiyana kungayambitse kulephera kwa aimpso.

Kulandila kwa Siofor kuyenera kuyimitsidwa masiku awiri asanachitike opaleshoni yomwe inakonzedwa, yomwe ikuchitika pansi pa opaleshoni yayikulu. Chithandizo chitha kupitiliza kwa masiku ena awiri atandichita opareshoni.

Simuyenera kuphatikiza kugwiritsa ntchito mankhwalawa ndi mankhwalawa omwe amawonjezera Hypoglycemic zotsatira.

Mankhwalawa amagwiritsidwa ntchito mosamala pochiza anthu okalamba omwe ali ndi zaka 65 zakubadwa.

Mulingo wololedwa magazi mkakakawiri pachaka. Ngati kudya kwa Siofor kuphatikizidwa ndi mankhwala ena omwe amachepetsa shuga, munthu amatha kuyendetsa mayendedwe amatha kukhala osokonezeka.

Glucophage, Dianormet, Glucophage XR, Metfogamma, Diaformin, Metformin Hexal.

Ma Analogs nthawi zina amagwiritsidwa ntchito ngati m'malo mwa Siofar. Ma fanizo otsatirawa amagwira ntchito: Metformin, Metfogamma, Forethine, Glucophage. Muli ndi zinthu zofananira, motero momwe zimakhudzira thupi zimafanana. Koma akatswiri okhawo omwe amatha kusintha mankhwalawa ndi analogues.

Zomwe zili bwino: Siofor kapena Glucofage?

Glucophage imakhala ndi metformin hydrochloride monga chophatikiza ndipo chimagwiritsidwa ntchito ngati chida cha mtundu 2 matenda a shuga komanso m'njira zovuta. Komabe, mankhwalawa, monga Siofor, sagwiritsidwa ntchito ngati njira yochepetsera thupi. Chifukwa chake, funso loti ndibwino kuti muchepetse kunenepa silolondola pankhaniyi.

Metformin kapena Siofor - ndibwino?

Mankhwalawa onse ali m'gulu la mankhwala amkamwa a hypoglycemic ndipo amatha kusinthana pambuyo povomerezedwa ndi dokotala. Dokotala amawona zoyenera kugwiritsa ntchito izi kapena mankhwalawa payekha.

Mpaka pano, palibe zambiri zachipatala, chifukwa mankhwalawa sagwiritsidwa ntchito pochiza ana.

Kuchepetsa thupi

Mankhwalawa amachepetsa shuga m'magazi, ndipo choyambirira, chimaperekedwa kwa anthu omwe ali nawo matenda ashugaamene ali onenepa kwambiri. Komabe, madokotala samathandizira omwe amagwiritsa ntchito Siofor kokha kuti achepetse thupi. Komabe, kuwunika kwa Siofor chifukwa cha kuchepa thupi kumawonetsa kuti, choyamba, mankhwalawa amachepetsa chikhumbo chofuna kudya maswiti.

Iwo omwe amalembetsa pazokambirana za momwe Siofor 500 kapena Siofor 850 ndi kuchepa thupi zimaphatikizidwira ndikuwona kuti kuchepa thupi kumachitika mwachangu kwambiri, makamaka kuphatikizidwa ndi kuchepa kwa calorie kudya komanso kuchita zolimbitsa thupi. Komabe, iwo omwe amamwa mapiritsi a zakudya amakhalanso ndi zovuta - colic, kupesa m'mimbazopumira pafupipafupi komanso zotayirira nseru.

Koma ngati munthu akuganiza zoyesa njira iyi yochepetsera thupi, muyenera kulangizidwa momveka bwino panjira ya momwe mungatenge Siofor kuti muchepetse kunenepa. Pankhaniyi, mankhwala amagwiritsidwa ntchito ndi mlingo wochepa wa yogwira - 500 mg. Muyenera kugwiritsa ntchito mapiritsi nthawi ya chakudya kapena musanadye.

Ngati zakudya zimatsatiridwa mukamamwa mankhwalawa, muyenera kukhala ochepa piritsi limodzi patsiku. Simungathe kumwa mankhwala osokoneza bongo ngati mutalemedwa kwambiri, musakanikize ndi mankhwala ena kuti muchepetse kunenepa, mankhwala othandizira, mankhwala okodzetsa. Njira ya mankhwalawa iyenera kusiyidwa ndi kutentha kwambiri, kuphwanya kwam'mimba kokwanira. Sindikulimbikitsidwa kumwa mankhwalawa kwa miyezi yopitilira 3.

Ndemanga za Siofor

Ndemanga za madotolo pa Siofor 1000, 850, 500 ndizabwino, koma akatswiri amafotokoza kuti mankhwalawa amayenera kumwedwa kokha ndi odwala omwe ali ndi matenda osokoneza bongo, osakhala athanzi, oonda anthu. Mankhwalawa amathandizira kubwezeretsa shuga moyenera komanso, anthu omwe ali ndi matenda osokoneza bongo omwe amatenga Siofor 850 kapena mankhwalawa mu mankhwala ena azindikira kuchepa.

Pa intaneti mutha kupeza ndemanga zambiri za iwo omwe achepetsa thupi mothandizidwa ndi chida ichi, omwe amati mukamamwa, chidwi chanu chimachepa. Koma ndemanga pa Siofor 500 yokhudza matenda ashuga, komanso malingaliro a iwo omwe adatenga chifukwa cha kuchepa thupi, amavomereza kuti atasiya kulandira chithandizo, kulemera kwake kumabwereranso msanga. Zimadziwikanso kuti mapiritsiwa ali ndi mtengo wotsika mtengo. Komabe, palinso ndemanga zambiri zoyipa zomwe zimadza chifukwa cha mankhwalawa. Makamaka, tikulankhula za zovuta pakugwira ntchito kwa chiwindi, kapamba, matumbo, m'mimba.

Siofor: Malangizo ogwiritsira ntchito

Siofor imatha kuchepetsa shuga m'magazi ndikuwongolera kupitilira kwa matenda ashuga a 2.
Chifukwa cha kumwa mankhwalawa, shuga amayamba kulochedwa m'magazi kuchokera pachiwindi.
Siofor simalola kuti chakudya chamafuta azitulutsidwa m'mwazi zochuluka.
Ma cell amthupi amayamba kuganizira kwambiri za insulin, zomwe zimathandizira kulowa kwa mahomoni mkati mwake.
Maziko a Siofor ndimankhwala ophatikizika a Metformin. Pambuyo polowa mthupi, simadziunjikira mkati, koma imakhudzidwa pamodzi ndi impso ndi chiwindi.

Mukatenga nthawi yanji

Siofor adalembedwa kuti pakhale mtundu wachiwiri wa matenda ashuga odwala 2, omwe amayang'anira matenda, osafunikanso zakudya zoyenera komanso masewera olimbitsa thupi.
Mankhwala amatha kuphatikizidwa ndi mankhwala ena. Itha kuikidwa pa insulin.
Nthawi zina mankhwalawa amagwiritsidwa ntchito pothana ndi kunenepa kwambiri, ngakhale matenda a shuga mwa odwala awa sanapezeke.
Siofor amagwiritsidwa ntchito muzochita zakuthala pamene mkazi awulula polycystic ovary syndrome.
Pali umboni kuti Siofor amalepheretsa kukalamba kwa maselo, mwakutalikitsa moyo wa odwala. Komabe, umboni wasayansi pakuganiza motere udakalibe.

Kodi osavomera

Zotsatira zosagwiritsidwa ntchito ndi mankhwalawa:

• Matenda akulu a shuga, omwe amaphatikizidwa ndi chiopsezo chokhala ndi ketoacidosis ndi chikomokere.
• Matenda opatsirana a thupi pathupi.
• Kuthetsa magazi pachimake.
• Kulephera kwa mtima.
• Kuthana ndi vuto lamtima. Mankhwalawa sanatchulidwe nthawi yoyambitsanso kukonzanso.
• Kuwonongeka kwa chiwindi, kupatula mafuta a hepatosis.
• Kuledzeretsa ndi chitukuko cha uchidakwa.
• Age ali pansi pa zaka 10.
• Kuwonongeka kwa impso, limodzi ndi kuchepa kwa kufalikira kwa glomerular mpaka 60 ml / mphindi kapena kuchepera.

Zomwe muyenera kulabadira mwapadera

Ngati wodwalayo akufuna kuchitidwa opaleshoni, kapena kumuyesa X-ray, ndiye kuti mankhwalawo ayenera kusiyidwa masiku 2 njira zisanachitike.
Ngati pali contraindication kutenga Siofor, amene sanaganiziridwe isanayambike chithandizo, wodwalayo angavutike kwambiri mu metabolic njira - lactic acidosis. Pankhaniyi, muyenera kukana kumwa mankhwalawo ndikupempha thandizo kuchipatala.
Pa chithandizo, ndikofunikira kuti musamangotsatira zakudya zoyenera, komanso kukhala ndi moyo wokangalika.

Pogogoda, mlingo wa mankhwalawa suyenera kupitirira 2550 mg. Kuphatikiza apo, piritsi lililonse lili ndi 850 mg, zomwe zikutanthauza kuti simuyenera kumwa mapiritsi oposa atatu patsiku.
Nthawi zina mlingo wa tsiku ndi tsiku umatha kuchuluka mpaka 3000 mg. Pankhaniyi, wodwalayo amapatsidwa mankhwala omwe mlingo wake ndi 1000 mg piritsi limodzi.
Mlingo woyamba wa mankhwalawa uyenera kutsitsidwa pang'ono. Chifukwa chake, odwala amapatsidwa piritsi limodzi mu 500 kapena 850 mg tsiku lililonse. Mlingo ukuwonjezeka bwino masabata angapo. Ngati wodwalayo amalola kuthandizidwa bwino, ndiye kuti masiku onse 11 mpaka 14 mlingo umachulukitsidwa, ndikumubweretsa pamlingo wofunikira.
Imwani mankhwala ndi chakudya.

Wodwala akayamba kuyamwa, ndiye kuti muyenera kukana kumwa mankhwalawo.
Zotsatira zina zoyipa ndizophatikiza:

Monga lamulo, pakatha masiku angapo kuyambira chiyambi cha chithandizo, zovuta zonse zosasangalatsa zidzayimitsidwa.
Ponena za hypoglycemia (vuto lomwe kuchuluka kwa shuga m'magazi limatsika kwambiri), Siofor sangachititse mkwiyo wake. Komabe, ngati adayikidwa limodzi ndi mankhwala ena, ndizosatheka kupatula chitukuko cha izi.
Ngati wodwala alandira jakisoni wa insulin panthawi ya chithandizo ndi Siofor, ndiye kuti mlingo uyenera kuchepetsedwa ndi 25%.
Ngati mankhwalawo ndiwotalikirapo, ndiye kuti mavitamini B12 adzachepa m'thupi. Izi zimayenera kukumbukiridwa popereka mankhwala kwa odwala omwe ali ndi vuto la kuchepa kwa magazi m'thupi.

Kubala mwana, kuyamwitsa

Siofor sinafotokozeredwe kuyamwitsa komanso nthawi yapakati.
Komabe, pakukonzekera kutenga pakati, Siofor amatha kupatsidwa kwa azimayi akapezeka ndi polycystic ovary syndrome. Ngati munthawi imeneyi kutenga pakati kumachitika, pomwe mayi sanadziwe ndikupitiliza kumwa mankhwalawo, ndiye kuti izi sizikuwopseza mayiyo chifukwa cha thanzi la mayi ndi mwana ndipo sayenera kuda nkhawa ndi izi.
Pa mkaka wa m'mawere, chithandizo ndi Siofor chimakanidwa, popeza chinthu chake chachikulu chomwe chimagwira umatha kulowa mkaka wa m'mawere.

Kuchita ndi mankhwala ena

Siofor sikulimbikitsidwa kuti iphatikizidwe ndi njira zakulera zam'mlomo, mahomoni a chithokomiro, zotumphukira za phenotazine, nikotini acid, Epinephrine ndi mankhwala ena. Izi ndizowopsa chifukwa akalowa mogwirizana, amatha kuchepetsa kuthandizidwa ndi Siofor.
Mavuto ena amakumananso kupatsa Siofor mankhwala osokoneza bongo kuti muchepetse magazi komanso kugwiritsa ntchito mankhwala osokoneza mtima.
Zonsezi zimatsimikiziranso kuti kufunsidwa mwatsatanetsatane kuchipatala ndikofunikira musanayambe chithandizo.

Ngati mwalandira mlingo waukulu

Mankhwala osokoneza bongo amawopseza kukula kwa lactic acidosis, koma odwala satenga hypoglycemia. Komabe, kudzikundikira kwa lactic acid m'magazi ndi zinthu zoopsa zomwe zimawopseza moyo. Pankhaniyi, wodwala amagonekedwa kuchipatala mwachangu. Pofuna kuchotsa mankhwalawa mthupi posachedwa, hemodialysis imafunika. Mofananamo, chithandizo chimachitika ndikuchotsa matenda osafunikira a matendawa.

Kuphatikizika, mawonekedwe omasulira ndi mawonekedwe osungira

Mankhwala amapezeka pokhapokha piritsi. Mapiritsiwo ndi owongoka kapena ozungulira powoneka ndi oyera mu utoto. Zili m'matuza omwe adapangidwa ndikunyamula makatoni. Mankhwalawa amachokera pa metformin hydrochloride, yomwe ndi yofunika kwambiri pakapangidwa. Mlingo umasiyana ndipo umatha kukhala 500, 850 kapena 1000 mg.
Monga zigawo zothandizira, zinthu monga hypromellose, macragolum, titanium dioxide, magnesium stearate, povidone, etc. zimagwiritsidwa ntchito.
Mankhwalawa amasungidwa kuchokera kwa ana kuti azitha kutentha osayenera kupitirira 25 ° C. Tsiku lotha ntchito kuchokera patsiku lopanga ndi zaka zitatu.

Siofor amapangidwa ndi kampani yaku Germany Berlin-Chemie AG / Menarini Gulu. Chofunikira chachikulu ndi metformin. Mtengo wa Siofor suli wokwera, chifukwa chake mankhwalawa amapezeka kuti angagulidwe ngakhale nzika zosauka za Russia. Komabe, ma analogi a Siofor akugulitsidwa, omwe amasiyana pamitengo yotsika.

Analogs a mankhwala a Siofor, omwe amapangidwa ku Russia:

Kampani ya Akrikhin imapanga mankhwala otchedwa Glformin.

Kampani ya Metformin-Richter imapanga mankhwala otchedwa Gedeon Richter-RUS.

Kampani ya Pharmstandard-Leksredstva imenya mankhwala otchedwa Fermetin.

Company ya Canonfarm Production imayambitsa mankhwala otchedwa Metformin Canon.

Siofor wakhala akugwiritsidwa ntchito pochiza odwala matenda a shuga kwa zaka zambiri. Izi zimakuthandizani kuti muweruzire mozama kukhathamira kwa mankhwalawa. Kuphatikiza pa kutumizidwa kwa odwala matenda ashuga, Siofor amatengedwa ndi anthu onenepa kwambiri.

Kuphatikiza pa mitengo yotsika mtengo yogulitsa zoweta, pamsika wama pharmacological mungapeze mankhwala amakampani akunja.

Izi zikuphatikiza:

Kampani yaku France Merk ipanga mankhwala otchedwa Glucofage.

Kampani yaku Germany ya Worwag Pharma imapanga mankhwala otchedwa Metfogamma.

Kampani yaku Bulgaria Sopharma imapereka mankhwalawa Sofamet kwa odwala matenda ashuga.

Kampani ya Israeli Teva ikuyambitsa Metformin-Teva.

Kampani ya Slovak Zentiva imatulutsa Metformin Zentiva.

Kugwiritsa ntchito mankhwala a Siofor muzochita zakuthwa

Ngati mzimayi wapezeka ndi matenda otupa a polycystic, adotolo amatha kumuwonetsa Siofor. Izi zimakuthandizani kuti muzitha kusintha kagayidwe kake mthupi, kusintha kayendedwe ka kusamba komanso ngakhale kubereka. Kuphatikiza pa kumwa mankhwalawa, akatswiri azachipatala amalimbikitsa odwala kuti azitsatira zakudya zochepa zomwe zimalepheretsa matenda ashuga amtundu wa 2.

Siofor ndi mtengo wotsika mtengo komanso wogwira ntchito pochiza matenda ovary. Chifukwa chake, amakhalabe mankhwala osankhidwa kwa odwala omwe ali ndi vutoli. Ngati palibe chithandizo kuchokera kuchipatala, amayamba kugwiritsa ntchito njira zina kuti akhale ndi pakati, mwachitsanzo, kupereka mankhwala a mahomoni, kuchita IVF, ndi zina. Nthawi zina, akatswiri azachipatala amalimbikitsa kutenga Siofor kwa odwala awo onenepa kwambiri. Nthawi yomweyo, mkazi amayeneranso kutsatira zakudya komanso masewera olimbitsa thupi.

Siofor ikhoza kulowa m'malo mwa Glucofage kapena Glucofage Long. Ndiye amene ali chida choyambirira chozikidwa pa metformin.

Kodi kusankha Siofor kapena Glyukofazh?

Glucophage ndi mankhwala oyamba ochizira matenda a shuga a 2. Siofor amachita ngati mnzake. Akatswiri ena amati glucophage samakhala woyambitsa mavuto, komanso amachepetsa shuga la magazi. Komabe, zambiri zimatengera umunthu wa wodwalayo. Mwambiri, kusiyana pakati pa mankhwalawo sikofunika. Chifukwa chake, ngati munthu akonda kugwiritsa ntchito mankhwala oyambirirawo kulandira chithandizo, ndiye kuti ayenera kusankha Glucofage. Ngati izi sizofunika kwa wodwala, ndiye kuti Siofor angagwiritsidwe ntchito.

Kodi Siofor amalembedwa ngati palibe shuga?

Mankhwala Siofor adziyambitsa okha chida chothandiza pakuchepetsa thupi. Chifukwa chake, anthu ambiri onenepa kwambiri amamwa mankhwalawa kuti achepetse thupi. Monga lamulo, izi zimachitika popanda upangiri wa udokotala. Mutha kugula Siofor popanda mankhwala.

Metformin ndi chinthu chomwe chimakuthandizani kuti muchepetse thupi popanda kuvulaza thanzi lanu. Pali chizolowezi chogwiritsa ntchito mankhwalawa kunenepa kwambiri kwa ana (kwa achikulire kuposa zaka 10).

Mpaka pano, maphunziro adayamba kale pachitika kuti Siofor atha kutalikitsa moyo. Komanso, izi ndizowona kwa anthu onenepa komanso owonda. Komabe, mpaka pano, maphunziro awa sanamalizebe.

Kulandila Siofora amakhudza chiwindi. Kodi izi ndi zowona?

M'malo mwake, Siofor sinafotokozeredwe odwala omwe ali ndi matenda enaake komanso matenda ena oopsa a hepatobiliary system. Mwambiri, shuga mellitus, yomwe imapangidwa ndi hepatic pathologies, imakhala yovuta kwambiri kuchiza.

Nthawi yomweyo, Siofor angagwiritsidwe ntchito pochiritsa odwala omwe ali ndi chiwindi chamafuta. Mofananamo, wodwalayo ayenera kutsatira zakudya zamafuta ochepa.

Ponena za funsolo la Siofor pachiwindi, zakudya zosenda ndi kusuta ndi zakumwa zoledzeretsa zimawononga thupi kwambiri. Mukasinthira pazakudya zoyenera, zomwe zilibe zakudya zopatsa thanzi, chiwindi chimayankhanso ndi thanzi.

Metformin ndi Siofor - pali kusiyana kotani?

Metformin ndi dzina la chinthu chomwe ndi gawo la mankhwala a Siofor. Chifukwa chake, funso loti kusiyana pakati pawo ndikosayenera.

Ndikofunikira kudziwa kuti Siofor ili ndi ma analogi ambiri apakhomo ndi akunja, omwe amakhalanso ndi metformin. Mankhwala oyamba kuchokera metformin ndi Glucofage.

Kulandila kwa Siofor kutengera chakudya

Mankhwalawa amatengedwa ndi chakudya kapena akangomaliza kudya. Ngati mumamwa mapiritsi pasadakhale, zimawonjezera chiopsezo cha zotsatira zoyipa zamagetsi. Mwachitsanzo, munthu amatha kudwala matenda otsekula m'mimba, kusangalala kwina, ndi zina zambiri.

Ngati wodwala akuvutika ndi kuchepa kwa shuga makamaka m'mawa, ndiye kuti madokotala amalimbikitsa kuti atenge Siofor madzulo asanagone. Komanso, zokonda ziyenera kuperekedwa kwa mankhwala ogwirizana ndi metformin wokhala ndi nthawi yayitali, mwachitsanzo, mankhwala Glyukofazh Long.

Mankhwalawa amayenera kukhala nthawi yayitali bwanji?

Ngati mayi ali ndi vuto la ovary la polycystic, ndiye kuti ayenera kumwa mankhwalawo mpaka athetse vutoli. Pambuyo pamimba, chithandizo chimayima.

Ngati Siofor amatchulidwa kuti alandire matenda a shuga 2, ndiye kuti ayenera kukhala okhalitsa. Nthawi zambiri, chithandizo cha mankhwala chimatenga nthawi yayitali. Mukakana kulandira chithandizo, munthu ayamba kunenepa, ndipo matendawa adzapita patsogolo.

Osawopa kugwiritsa ntchito mankhwalawa kwa nthawi yayitali. Izi sizingawononge thanzi, koma, m'malo mwake, ndizithandizira kuti ziziteteza. Komanso, kwa odwala matenda ashuga, chithandizo ndichofunikira kwambiri.

Kuti mupewe kuchepa kwa magazi m'thupi kwa B12, komwe kumatha kuchitika chifukwa cha chithandizo cha nthawi yayitali ndi Siofor, madokotala amalimbikitsa kumwa Vitamini B12 kamodzi kapena kawiri pachaka. Nthawi yomweyo, ndizosatheka kukana chithandizo chachikulu.

Kodi nditha kumwa mankhwalawa ndimodzimodzi tsiku limodzi?

Ngati mutenga Siofor tsiku lililonse, simudzakwanitsa kuchepetsa shuga la magazi. Komanso, sizingathandize kutaya mapaundi owonjezera. Chifukwa chake, muyenera kutsatira mosamalitsa malangizo azachipatala ndikumwa mankhwalawa malinga ndi malangizo, ndiye kuti, tsiku ndi tsiku.

Mlingo woyambirira wa mankhwalawa uyenera kukhala 50 mpaka 850 mg patsiku. Kuti mubweretse pazovomerezeka kwambiri, zimatenga nthawi.

Siofor ndi mowa

Mukamachitira ndi Siofor, mutha kumwa mowa, koma ochepa. Komabe, ndendende za zakumwa zochepa za mowa. Ngati malingaliro awa anyalanyazidwa, ndiye kuti mwayi wokhala ndi vuto lalikulu, makamaka lactic acidosis, ukuwonjezeka. Mkhalidwe uwu ndiwopseza moyo. Chifukwa chake, kugwiritsa ntchito moledzera mowa koletsedwa.

Nthawi yomweyo, chithandizo ndi Siofor sichikakamiza munthu kusiya mowa mpaka kalekale. Ngati palibe zotsutsana zina ndi zina zilizonse kuti mumwe, ndiye kuti nthawi zina amaloledwa kumwa pang'ono. Pankhaniyi, palibe kudalira nthawi yomwe mumamwa mankhwalawa chifukwa cha kumwa, ndiye kuti, kumamwa mowa ndikololedwa nthawi yomweyo mutangomwa mlingo wotsatira.

Pazipita tsiku lililonse mankhwala a Siofor

Monga tafotokozera pamwambapa, kuyamba kulandira chithandizo chokhala ndi Mlingo wambiri watsiku ndi tsiku ndizoletsedwa. Thupi likasintha, wodwala amafunika kumwa piritsi limodzi katatu patsiku, pakudya kwakukulu. Mlingo umodzi ndi 850 mg.

Ngati munthu wamwa mankhwala osachiritsika kwanthawi yayitali, ndiye kuti mlingo wa metformin wokwanira tsiku lililonse umatsitsidwa mpaka 2000 mg. Imwani mankhwalawa musanagone, kamodzi patsiku. Izi zitha kupewa kulumpha m'mawa m'magazi.

Nthawi zambiri anthu amatenga Siofor pawokha kuti achepetse kukalamba kwa thupi. Pankhaniyi, palibe chifukwa chomamwa mankhwalawa tsiku lililonse. Ndikokwanira kuchepa 500-500 mg pa kugogoda. Zowonjezera zokhudzana ndi kutenga kukalamba kwa Siofor pakadali pano zikusowa.

Hypothyroidism ndi Siofor: mawonekedwe olandirira

Hypothyroidism sikuti kuphwanya kutenga Siofor. Mankhwala amalola kuti muchepetse thupi, koma sangathe kuthetsa vuto la kuchepa kwa mahomoni m'thupi.

Endocrinologist amathandizika pa matenda a hypothyroidism. Ndiye amene ayenera kusankha mankhwala a mahomoni, omwe amachokera pa kudziwa kwa wodwala wina.

Komanso, anthu omwe ali ndi vuto la hypothyroidism ayenera kutsatira zakudya, kuchotsa chakudya kuchokera pamenyu omwe angayambitse kuwonongeka. Chithandizo chitha kuphatikizidwa pomwa ma vitamini-mineral complexes.

Kulandila Prophylactic Siafora

Kupewera kwa matenda ashuga amtundu wa 2 kumakhudzanso zakudya zamagulu ochepa. Palibe mankhwala amodzi, kuphatikiza ena okwera mtengo kwambiri, omwe amatha kuletsa kukula kwa matendawa ngati munthu akudya zakudya zopanda pake.

Kutsatira mfundo za kadyedwe kabwino ndikukhalabe ndi moyo wathanzi ndizothandiza kwambiri kupewa osati matenda ashuga okha, komanso kuthamanga kwa magazi, atherosclerosis ndi zina matenda.

Ndi mankhwala ati omwe angalowe m'malo mwa Siofor?

Kupeza m'malo mwa Siofor kumakhala kovuta kwambiri, chifukwa mawonekedwe ake othandizira (metformin) amatha kutchedwa kuti osiyana. Nthawi zina kutenga Siofor sikulola kutsitsa shuga ya magazi kukhala milingo yomwe mukufuna. Mwambiri, izi zikuwonetsa kuti wodwala wadwala matenda ashuga, kapena mtundu wachiwiri wa shuga wadutsa mtundu woyamba wa matenda ashuga. Pankhaniyi, palibe mankhwala ochepetsa shuga omwe angathandize wodwalayo. Jakisoni wa insulin adzafunika. Kasitomala wathetsa zonse zomwe zasungidwa ndipo salinso kupanga insulini. Munthu amayamba kuchepa thupi kwambiri, amakumana ndi zovuta za matenda ashuga. Ngati mankhwala a insulin sanayambike munthawi yake, wodwalayo adzafa.

Nthawi zina odwala amafuna kulowa Siofor osati chifukwa sizithandiza, koma chifukwa mankhwalawa amayambitsa zotsatira zoyipa kuchokera mthupi, mwachitsanzo, kutsegula m'mimba. Pankhaniyi, mutha kuyesa kusinthana ndi mankhwala Glyukofazh Long. Kuwonjezereka kosavuta kwa mankhwalawa kungathandize kuthana ndi mavuto am'mimba. Kwakukulukulu, zikuwonetsa kuti kutsekula m'mimba kumachitika mwa odwala omwe sanatsatire lamuloli, nthawi yomweyo akuyamba kumwa mankhwalawa tsiku lililonse.

Mphamvu ya Siofor ku ziwalo zamkati komanso kuzungulira kwa mahomoni

Ngati wodwala ali ndi mafuta a chiwindi a hepatosis, ndiye kuti kutenga Siofor kumathandiza kuthana ndi kuphwanya izi. Izi zimatheka pokhapokha ngati munthu atsatira chakudya chochepa chamafuta. Ngati wodwalayo ali ndi chiwindi, ndiye kuti muyenera kufunsa katswiri wokhudzana ndi kuthekera kwa mankhwalawo.

Siofor amathandizira kuchepetsa shuga m'magazi ndipo amathandizira kupewa kufooka kwa impso. Komabe, ngati munthu ali kale ndi matenda a impso, ndiye kuti kutenga Metformin kumatsutsana. Chifukwa chake, musanayambe chithandizo, muyenera kudutsa mayeso oyenera.

Siofor ndi mankhwala omwe amakulolani kuchepa thupi. Ngati munthu ali ndi thanzi, ndiye kuti mankhwalawa sangathe kuyambitsa impso ndi chiwindi.

Amayi akamatenga Siofor pochiza matenda a ovary polycystic, ndiye kuti mahomoni awo amakhala bwino.

Za mankhwala a Siofor, mutha kupeza ndemanga zabwino komanso zoyipa.

Anthu akuwonetsa kuti kumwa mankhwalawa kumatha kuthana ndi chidwi chofuna kudya kwambiri komanso kutaya makilogalamu awiri mpaka 15 kuchokera ku thupi, ngakhale mzere wambiri wazowuma kuyambira 3 mpaka 6 kg.

Pali ndemanga pankhani yoti Siofor amayambitsa matenda am'mimba komanso matenda ena ammimba. Komabe, ngati muwerenga malingaliro awa mosamala, zimapezeka kuti zidalembedwa ndi anthu omwe adayamba kulandira chithandizo mosachedwa kwambiri. Izi zikutanthauza kuti mwina sanakaonane ndi dokotala kapena sanawerenge malangizo kuti agwiritse ntchito. Ngati mlingo umakulirakudya bwino, mavuto omwe ali ndi chimbudzi angapewe. Zomwezi ndizofanana ndi zovuta zina.

Sizikudziwika ngati mankhwalawo amabwerera pambuyo pa kutha kwa mankhwalawa. Akatswiri akukhulupirira kuti gawo la ma kilogalamu otayika lidzasinthidwanso. Odwala ena atasiya kumwa mankhwalawa amapitilizabe kutsatira zakudya, ndipo kulemera kwawo kumasungidwa pamlingo womwe angafune. Komabe, kuti muchite izi muyenera kusintha kaganizidwe kanu ndi kakhalidwe kwanu onse.

Kwa odwala omwe ali ndi matenda a shuga a 2, Siofor ndiye chipulumutso chenicheni. Mankhwalawa amakulolani kuti musangochepetsa thupi, komanso kuti muziyang'anira matenda anu.

Chifukwa chake, kuwunika kosavomerezeka nthawi zambiri kumasiyidwa ndi odwala omwe samawerenga mosamala malangizo omwe amamwa mankhwalawo ndikusokoneza, zomwe zimapangitsa kuti pakhale zovuta zoyipa.

Kumbukirani kuti chithandizo cha matenda osokoneza bongo amatsika osati kumangomwa mankhwalawo, komanso kutsatira zakudya. Popanda izi, chithandizo chamankhwala sichitha. Sikukwanira kudziyika nokha mu mafuta ndi kilocalories, ndikofunikira kuti muchepetse kudya zakudya zamafuta. Ngati izi sizichitika, ndiye kuti matenda ashuga apitilizabe kupita patsogolo, ngakhale ali ndi chithandizo chanthawi zonse. Komanso, ngakhale wodwala atamwa mankhwala okwera mtengo kwambiri, omwe Siofor satanthauza.

Za adotolo: Kuyambira 2010 mpaka 2016 Othandizira pachipatala chachipatala chapakati chaumoyo Na. 21, mzinda wa elektrostal. Kuyambira mu 2016, agwira ntchito ku malo ozindikira matenda No. 3.

Njira zoyenera kutsata mankhwala azitsamba azitsamba zilizonse zazikazi (matenda azitsamba)

Momwe mungachedwetsere magazi komanso kuthamanga?

Kutulutsa mawonekedwe ndi kapangidwe kake

Mlingo wa Siofor 500 - mapiritsi okhala ndi mbali: yoyera, yozungulira, ya biconvex (zidutswa 10 chilichonse pachimake, mu bokosi la makatoni 12, 6 kapena 3 matuza).

Piritsi limodzi lili:

• yogwira mankhwala: metformin hydrochloride - 0,5 g,
• othandizira zigawo: povidone, hypromellose, magnesium stearate,
• kapangidwe kazigoba: hypromellose, titanium dioxide (E171), macrogol 6000.

Pharmacokinetics

Mayamwidwe amkamwa a metformin amapezeka m'matumbo am'mimba. Kuchuluka kwa plasma kumachitika pambuyo pa maola 2,5. Mutatenga mlingo waukulu, sizidutsa 0,004 mg / ml. Kumwa mankhwala ndi chakudya kumabweretsa kuchepa kwa mayamwidwe ndi kutsika pang'ono. Mu odwala athanzi, bioavailability ya mankhwala pafupifupi 50-60%.

Kudzikundikira kwazinthu zomwe zimagwira kumachitika m'magazi, chiwindi, impso ndi minofu, ndipo metformin imalowanso m'magazi ofiira a m'magazi. Kumangiriza kwa mapuloteni a plasma sikuchitika. Voliyumu yogawa ikhoza kukhala malita 63-276.

Hafu ya moyo wa mankhwalawa ndi pafupifupi maola 6.5. Osasinthika, amathandizidwa kudzera mu impso. Kuwonekera kwa aimpso kwa metformin kopitilira 400 ml / min.

Ndi vuto laimpso, kuwonongeka kwa metformin kumachepera mogwirizana ndi creatinine chilolezo (CC). Izi zimapangitsa kuchuluka kwa theka la moyo komanso kuchuluka kwa metformin m'madzi am'magazi.

Zizindikiro zogwiritsidwa ntchito

Malinga ndi malangizo, Siofor 500 akuwonetsedwa pochiza matenda a shuga 2 omwe amalephera kugwiritsa ntchito mankhwala olimbitsa thupi komanso masewera olimbitsa thupi, makamaka kwa odwala onenepa kwambiri.

Mankhwala amatchulidwa ngati monotherapy kapena ngati gawo limodzi la mankhwala othandizira ndi insulin. Kuphatikiza apo, mu akulu - osakanikirana ndi ena am'kamwa a hypoglycemic othandizira.

Malangizo ogwiritsira ntchito Siofora 500: njira ndi mlingo

Mapiritsi a Siofor 500 amatengedwa pakamwa pakudya kapena pambuyo chakudya.

Malangizo, phwando lamankhwala, nthawi ya maphunzirowa, dokotala amadziwonetsa payekhapayekha, poganizira kuchuluka kwa kuchuluka kwa shuga m'magazi a m'magazi.

Mlingo woyenera wa akulu:

• monotherapy: koyamba mlingo - 1 pc. (0.5 g) nthawi 1-2 pa tsiku kwa masiku 10-15. Kenako, mutapatsidwa kuchuluka kwa shuga m'magazi am'magazi, mlingowo umakulitsidwa pang'onopang'ono mpaka zidutswa za 3-4. patsiku. Kuwonjezeka kwapang'onopang'ono kwa mankhwalawa kumapewa kupewetsa ziwonetsero za kusalephera kwa m'mimba. Mlingo wapamwamba tsiku lililonse ndi 6 ma PC. (3 g) logawika 3,
• kuphatikiza mankhwala ndi insulin: koyamba mlingo - 1 pc. 1-2 patsiku. Mlingo uyenera kuchuluka pang'onopang'ono, ndi masiku 7. Wapakati tsiku ndi tsiku mutatha kuchuluka ndi ma PC atatu. Mlingo wa insulin umatsimikizika potengera kuchuluka kwa shuga m'magazi. Mlingo wa tsiku ndi tsiku wa mankhwalawa sayenera kupitirira 6 ma PC., Iyenera kugawidwa m'magawo atatu.

Kusintha ndikugwiritsa ntchito wothandizila wina wodwala matenda ashuga kumachitika poyimitsa koyamba komanso koyambirira kwa kumwa Siofor 500 pazodzo pamwambapa.

Kwa odwala okalamba, mlingo wa mankhwalawa uyenera kuikidwa mosamala kwambiri, kungodziwa kuchuluka kwa creatinine m'madzi a m'magazi. Chithandizo chiyenera kuyang'aniridwa ndi impso.

Mlingo wovomerezeka wa Siofor 500 wa ana opitirira zaka 10 ndi monotherapy komanso kuphatikiza ndi insulin: koyamba mlingo - 1 pc. (0.5 g) 1 nthawi patsiku. Kuti mukwaniritse kuyesedwa koyenera pambuyo pa masiku 10-15 mukuyendetsa, mutha kuyamba kuwonjezera pang'onopang'ono mlingo kutengera glucose m'magazi a m'magazi. Mlingo wapamwamba wa tsiku lililonse wa ana a zaka 10 mpaka 18 ndi 4 ma PC. (2 g of metformin) mu waukulu Mlingo 2-3. Mlingo wa insulin umatsimikizika potengera kuchuluka kwa shuga m'magazi am'magazi.

Ndi poika 4-6 ma PC. (2-3 g) patsiku, mutha kugwiritsa ntchito mapiritsi a mankhwala osokoneza bongo 1 g (Siofor 1000).

Kukopa pa kuthekera koyendetsa magalimoto ndi njira zowerengeka

Kugwiritsa ntchito kwa Siofor 500 monga monotherapy sikumayambitsa hypoglycemia ndipo sikukhudza kuthekera kwa wodwala kuyendetsa magalimoto kapena makina osiyanasiyana.

Monga gawo la kuphatikiza mankhwalawa ndi othandizira ena a hypoglycemic, Siofor 500 ikhoza kuyambitsa kukhazikitsidwa kwa zochitika za hypoglycemic, motero odwala ayenera kusamala kuti agwire ntchito zowopsa zomwe zimafunikira chidwi komanso kuthamanga kwa ma psychomotor.

Mimba komanso kuyamwa

Kugwiritsa ntchito Siofor 500 kumapangidwa pakamwa ndi poyamwitsa.

Wodwala yemwe ali ndi mtundu wachiwiri wa matenda a shuga ayenera kuchenjezedwa za zomwe zimayenera kuuzidwa kwa adokotala kuti akonzekere kapena atangoyamba kumene kubereka, popeza munthawi imeneyi mankhwalawa amayenera kutha ndipo chithandizo cha insulin chiyenera kugwiritsidwa ntchito kutithandizira kapena kuyerekezera kuchuluka kwa shuga m'magazi a mayi woyembekezera. Izi zimachepetsa chiopsezo cha matenda a hyperglycemia pakukula kwa mwana wosabadwayo.

Popeza kufunika kogwiritsa ntchito mankhwalawa panthawi yoyamwa, adokotala ayenera kusankha kusiya Siofor 500, kapena kusiya kuyamwitsa.

Palibe chidziwitso pakufika kwa metformin mkaka wa m'mawere wa amayi.

Gwiritsani ntchito paubwana

Siofor sayenera kulembedwa kwa ana 500 osakwana zaka 10.

Chenjezo uyenera kugwiritsidwa ntchito pochiza ana azaka zapakati pa 10-12.

Ana azaka zapakati pa 10 mpaka 18 akuwonetsedwa kugwiritsa ntchito Siofor 500 pa monotherapy komanso kuphatikiza ndi insulin. Mlingo woyambirira ndi piritsi limodzi (0.5 g) 1 nthawi patsiku. Pambuyo masiku 10,5 oyendetsa, kuwonjezeka kwapang'onopang'ono kwa mlingo kumasonyezedwa mukuganizira kuchuluka kwa shuga m'magazi am'magazi. Mulingo wambiri watsiku ndi tsiku ndi mapiritsi 4 (2 g a metformin) mu 2-3. Mlingo wa insulin umatsimikizika potengera kuchuluka kwa shuga m'magazi am'magazi.

Gwiritsani ntchito mu ukalamba

Kwa odwala okalamba (azaka zopitilira 60) omwe zochitika zawo zimagwirizanitsidwa ndi kuchita masewera olimbitsa thupi, mankhwalawa ayenera kuyikidwa mosamala chifukwa chowonjezera chiopsezo cha lactic acidosis.

Mlingo wa Siofor 500 uyenera kutsimikizika pamaziko a zisonyezo za creatinine m'madzi a m'magazi. Chithandizo chikuyenera kuyendera limodzi ndi kuyang'anira magwiridwe antchito a impso.

Kuyanjana kwa mankhwala

Kugwiritsidwa ntchito kwa metformin kumapangidwira nthawi imodzi ndi jekeseni wamitsempha yama cell omwe amakhala ndi zotsutsana, chifukwa izi zingayambitse kulephera kwa impso komanso kuwerengera kwa metformin wodwala. Chifukwa chake, ngati kuli kofunikira kugwiritsa ntchito mankhwala osokoneza bongo omwe ali ndi ayodini pakuwunika kwa X-ray mwa odwala omwe ali ndi seramu creatinine, kutenga Siofor 500 kuyenera kuyimitsidwa maola 48 isanachitike ndikuyambitsanso maola 48 atatha phunzirolo. Othandizira ena a hypoglycemic, monga insulin, ayenera kugwiritsidwa ntchito panthawiyi.

Sitikulimbikitsidwa kuphatikiza kumwa mankhwalawo ndi ma ethanol omwe amakhala ndi othandizira kumwa. Kuledzera kwa pachimake kapena kugwiritsa ntchito munthawi yomweyo mankhwala okhala ndi ethanol, makamaka motsutsana ndi maziko a kulephera kwa chiwindi, chakudya chosokoneza thupi kapena kufa ndi njala, kumawonjezera chiopsezo cha lactic acidosis.

Ndi munthawi yomweyo kugwiritsa ntchito Siofor 500:

• danazol angathandizire kukulitsa kwa vuto la hyperglycemic, motero, kusintha kwa metformin kumafunikira pakukonzekera komanso atasiya kutulutsa danazol, poganizira kuchuluka kwa shuga m'magazi a m'magazi,
• zotumphukira za sulfonylureas, insulin, acarbose, salicylates zingayambitse kuchuluka kwa hypoglycemic ya mankhwala,
• kulera pakamwa, epinephrine, glucagon, mahomoni a chithokomiro, phenothiazine ndi nikotini acid zotumphukira zimatha kuwonjezera kuchuluka kwa shuga m'magazi am'magazi,
• nifedipine imachulukitsa mayamwidwe ndi kuchuluka kwa metformin m'madzi a m'magazi, amachepetsa mayeso ake,
• cimetidine amalimbikitsa kuthetsedwa kwa mankhwalawa, kuwonjezera chiwopsezo cha lactic acidosis,
• amiloride, morphine, quinidine, procainamide, ranitidine, vancomycin, triamteren (mankhwala a cationic) omwe amagwiritsidwa ntchito kwa nthawi yayitali atha kuwonjezera kuchuluka kwa metformin m'magazi am'magazi,
• anticoagulants angathenso kufooketsa mphamvu zawo zochizira,
• furosemide amachepetsa kwambiri ndende yake ndi theka-moyo,
• beta-adrenergic agonists, okodzetsa, glucocorticoids ali ndi zochita za hyperglycemic,
• antihypertensive othandizira, kuphatikizapo angiotensin-otembenuza enzyme inhibitors, amatha kutsitsa shuga m'magazi a plasma.

Ma Analogs a Siofor 500 ndi awa: Bagomet, Diaformin, Glformin, Metformin, Glyukofazh, Metfogamma, Formmetin.

Kufotokozera ndi kapangidwe

Mapiritsiwo ndi oyera, osadukiza. Phwando lowoneka bwino lomwe lili pakatikati pa chinthucho. Yogwira ntchito ya mankhwala ndi metformin hydrochloride.

Mndandanda wazida zothandizira umaperekedwa motere:

Zomwe chipolopolocho chili ndi zigawo izi:

Gulu la mankhwala

Siofor ndi mankhwala osokoneza bongo a hypoglycemic.

Hypoglycemic wothandizira kuchokera mndandanda wa Biguanides. Amapereka shuga m'magazi a wodwala komanso oyambira pambuyo pake. Gawo lolimbikira silithandiza kupanga insulin chifukwa chake silitsogolera ku hypoglycemia. Zotsatira za metformin mwina zimatengera mawonekedwe:

• kuchepa kwamphamvu kwa kupanga kwa shuga m'chiwindi chifukwa kuchepa kwa gluconeogeneis ndi glycogenolysis,
• kuchuluka kwa minofu kumva insulin,
• kusintha kwa zophatikizira shuga ndi kuwononga kwake,
• kuletsa kwamatumbo a glucose.

Pambuyo pakukonzekera pakamwa, pazinthu zambiri za plasma zimafikiridwa pambuyo pafupifupi maola awiri. Chakudya chikatha, kunyowa kumalephereka ndipo kumachepetsa. Mndandanda wa bioavailability mwa odwala wathanzi ndi 50-60%. Chithandizo chogwira ntchito sikugwirizana ndi mapuloteni a plasma. Amachotsa mkodzo m'thupi la wodwalayo.

Kwa akuluakulu

Ngati pali zisonyezo zogwiritsidwa ntchito, mankhwalawa amatha kuperekedwa kwa odwala akuluakulu. Musanagwiritse ntchito malonda, muyenera kuwerenga malangizo kuti agwiritse ntchito. Zotsatira zoyipa zikagwiritsidwa ntchito pakupanga mankhwala, chithandizo chimayima ndipo njira yatsopano yowonetsera imasankhidwa.

Mankhwala Siofor sagwiritsidwa ntchito pochita ana. Malangizo ogwiritsira ntchito amadziwitsa kuti mankhwalawa amatha kugwiritsidwa ntchito kokha kwa ana opitirira zaka 14. Mkhalidwe wa wodwalayo uyenera kuyang'aniridwa pafupipafupi.

Kwa pakati ndi kuyamwitsa

Mankhwala Siofor amaphatikizidwa kuti agwiritse ntchito panthawi yoyembekezera komanso yoyamwitsa. Wodwala ayenera kukumbukira kufunika kudziwitsa katswiri wa endocrinologist. Mayi yemwe akukonzekera kutenga pakati ayenera kudziwitsa katswiri wa izi; Mtsikanayo amasamutsidwa kupita ku insulin. Ndikofunikira kusankha mlingo womwe umakupatsani kukhazikika kwa shuga m'magazi. Kupereka koteroko kumachepetsa mwayi wowonekera kwa zovuta za fetal zomwe zimayambitsidwa ndi hyperglycemia.

Tisaiwalenso kuti gawo lomwe limagwiritsa ntchito mankhwalawa limadutsa mkaka wa m'mawere. Ngati ndizosatheka kuleka kumwa Siofor panthawi yoyamwitsa, mwana amasinthidwa ndi chakudya ndi mkaka wosakaniza.

Malo osungira

Mankhwala amaperekedwa kuchokera kuzipatala zamankhwala kwa odwala omwe amapatsidwa malangizo kuchokera kwa katswiri wa endocrinologist. Kugwiritsa ntchito mankhwala mosavomerezeka kumapangitsa kuti munthu akhale wathanzi. Kuti tisunge zochizira, tiyenera kutsatira malangizo oyenera oti tisungidwe: kutentha kwa chipinda mpaka madigiri 25, chitetezo kuchokera ku chinyezi ndi kuwala kwadzuwa. Sungani mankhwalawo kwa ana otetezeka. Nthawi yovomerezeka ndi zaka 2 kuyambira tsiku lopangidwa. Kugwiritsa ntchito malonda atatha izi ndizoletsedwa.

Pogulitsa mutha kupeza zofananira za Siofor:

1. Glucophage, mankhwalawa amapangidwa m'mapiritsi, omwe amakhala ndi metformin monga chinthu chogwira ntchito. Awa ndi mankhwala aku Europe, omwe amawononga mtengo wotsika mtengo kuposa Siofor, koma nthawi yomweyo samatsika kuposa iwo mwabwino. Mankhwala amavomerezedwa kuti azigwiritsidwa ntchito mwa ana opitilira zaka 12.
2. Glucophage Kutalika. Mankhwalawa amapezeka m'mapiritsi omwe amatulutsidwa pang'onopang'ono ndi metformin, yomwe imakupatsani mwayi woti muzimwa kamodzi kokha patsiku nthawi yogona, koma, mwatsoka, imaperekedwa kwa odwala omwe ali ndi zaka 18. Amasiyananso ndi Siofor pama kapangidwe kazinthu zina.
3. Bagomet Plus. Mankhwala osakanikirana okhazikika, zosakaniza zomwe ndi metformin ndi glibenclamide. Chifukwa chomwe achire zotsatira za mankhwalawo amatchulidwa. Amaloledwa kugwiritsa ntchito mankhwalawa pokhapokha pochiza odwala azaka zopitilira 18. Simalimbikitsidwa kwa odwala opitirira zaka 60.
4. Galvus Met ndi mankhwala osakaniza a ku Switzerland omwe zosakaniza zake ndi metformin ndi vildagliptin. Onsewa amachepetsa shuga m'magazi ndipo amathandizira pakuthandizira wina ndi mnzake ndipo amadziwika kuposa Siofor. Mankhwalawa amatha kugwiritsidwa ntchito kwa odwala azaka zopitilira 18.

Ndalama zomwe zatchulidwa zitha kugwiritsidwa ntchito ngati zofunikira m'malo mwa mankhwala, komabe, ndikofunikira kukambirana ndi kusintha kwa mankhwala a Siofor ndi analogues ndi katswiri.

Mtengo wa Siofor ndi pafupifupi ma ruble 315. Mitengo kuyambira 197 mpaka 481 rubles.

Madokotala amawunika za Siofor 500

Siofor (metformin) - mankhwala omwe amasintha kagayidwe kazachilengedwe komanso minyewa yamphamvu ya insulin. Muzochita zanga, ndimapereka mankhwala (mwatsoka!) Ana, nthawi zambiri mu unyamata. Amasonyezedwa za matenda a shuga a mtundu wachiŵiri pankhani ya kukana insulini mwa mwana, osati aliyense amene ali ndi PCOS, osavomerezeka ndi kulolerana kwa shuga.

Amachepetsa mulingo wa vitamini B12.

Mu ana endocrinology si mankhwala osankha. Zimapereka zovuta zambiri!

Mulingo wa "golide" wamakono wa endocrinology ndi matenda ashuga. Kuchita bwino kwa mankhwalawa sikukayikira. Ndimaligwiritsa ntchito pochita kuchipatala pafupifupi tsiku lililonse. Zotsatira zabwino komanso zoyipa zaphunziridwa bwino, mankhwalawa ndiwonetseratu, omwe ndiofunikira.

Nthawi zina odwala amadandaula za matenda otsegula m'mimba, kusanza, kusasangalala kwam'mimba. Koma! Nthawi zambiri, pakatha nthawi yoti zizolowere, zonsezi zimatha. Ndipo ngati sachepetsa kwambiri moyo wa wodwalayo, ndiye kuti sinditha kuletsa mankhwalawo!

"Metformin", "Siofor" imatha kupanga nyimbo zosiyanasiyana. Zimathandiza odwala ambiri kukhala athanzi!

Mankhwalawa ndi abwino kwambiri, amagwiritsidwa ntchito nthawi zambiri ndi mtundu wachiwiri wa matenda a shuga, omwe ali ndi matenda a prediabetes (kusokonezeka glycemia, kulolera shuga), ndi PCOS. osati onse osati nthawi zonse, koma ambiri amawonetsedwa.

Nthawi zina pamakhala chopondapo monga zotsatira zoyipa, motero odwala ayenera kuchenjezedwa za kuyamba kulandira chithandizo sabata isanakwane (kuti zovuta kuntchito zizichitika).

Kukana kwa insulin kumatanthauza Metformin (Siofor).

Ndemanga za Odwala a Siofor 500

"Siofor" adandiuza kuti ndiopanga matenda a shuga. Poyamba zonse zinali bwino, kenako sanali kumva bwino. Zinayamba kusanza masana, m'mimba mumakhala kuwawa. Ndinafunika kusiya. Adotolo adasinthidwa ndi Glucofage.

Mankhwala "Siofor" adayamba kugwiritsidwa ntchito mwezi womwe wapitayo potsatira lingaliro la dokotala. Kumayambiriro kwa ntchito panali zovuta zina zam'mimba ndi zowawa zam'mimba, koma patatha milungu iwiri zonse zidapita. Ndimakonda mankhwalawa chifukwa amachepetsa kudya komanso amathandizira kuti glucose azikhalapo bwino, zomwe zimapangitsa kuti thupi lizithamanga.

Agogo anga akudwala matenda osokoneza bongo omwe samadalira insulin, akhala akumwa mankhwala ambiri kwa zaka zingapo, kuphatikiza ndi Siofor. Amagwiritsa ntchito mankhwalawa kutsitsa shuga wamagazi ndikuyitcha kuti yothandiza kwambiri pazomwe zimamuyesa zaka zambiri. Amamwa katatu patsiku ndipo shuga amakhala bwino kwambiri m'dera la 7-8, izi ndi zotsatira zabwino kwa thupi lake. Posachedwa, amatha ngakhale kudya pang'ono lokoma, koma chifukwa cha mankhwalawa, izi sizikhudza thanzi lake. Zokhazo zoyipa ndizokwera mtengo.

Sindinapite motsimikiza! Anawononga tsiku lovuta m'moyo wake - zonse zidapweteka: onse mutu ndi zamkati, ngati kuti watentha ndi moto! Kuphatikiza pa chisangalalo, kusanza kosalekeza nthawi yomweyo monga kupukusira m'mimba kosalekeza! Pafupifupi maola 24 atalandiridwa, zinali ngati kusinthana kwadina - zonse zapita! Nthawi ya piritsi yatsopano! Ndidaganiza kuti palinso njira zina zopewera moyo wanga, ndipo ndidalumikizana ndi Siofor.

Dokotala adandiwuza kuti ndikhale ndi Siofor 500 zaka zitatu zapitazo. Ndimagwiritsa ntchito piritsi lililonse 1 piritsi limodzi ndi chakudya kuti ndisinthe shuga m'magazi, chifukwa ndimadwala matenda ashuga. Munthawi yopereka zovuta zowonekera, sizinawonekere. Koma sindinganene kuti 100% kuti amasintha shuga kwathunthu, chifukwa nthawi zina chizindikiro changa chimakwera kwambiri. Ndikofunikira kwambiri kudya ndikusunga zomwe mumadya ngakhale mumamwa mankhwalawa.

Idasankhidwa kangapo. Pa mlingo wocheperako, mwezi woyamba umakhala wovuta kwambiri, umakhudza bile, umabweretsa kupweteka kwambiri. Kenako chizolowezi chimayamba, koma ndikuwonjezeka kwa kuchuluka kwa kupweteka mu ndulu amalekerera, ndinayenera kusiya mankhwalawo. Glucofage ndiyabwino kwambiri, komanso 500.

Zimathandizira kuchotsa kukana kwa insulin ndi shuga wambiri (kutsitsidwa kuchoka pa 5.6 mpaka 4.8 m'miyezi itatu). Anachiritsa polycystic.

Koma sanandithandizire, endocrinologist amayenera kundisamutsira insulin, koma sindinkafuna kwenikweni. Ndinkakhala ndi chiyembekezo chonse cha kusayipa!

Ndakhala pa Siofor pafupifupi zaka zitatu - zonse zili bwino, palibe mankhwala osokoneza bongo, shuga amapezeka paliponse. Koma endocrinologist anandiuza nthawi yomweyo kuti palibe siofor yemwe angalowe m'malo mwa zakudya. Chifukwa chake malingaliro amayenera kutsatiridwa mulimonse.

Kufotokozera kwapfupi

Siofor (INN - metformin) ndi mankhwala othandizira omwe ali m'gulu la Biguanide. Imakhala ndi antihyperglycemic, ndipo imatha kuchepetsa kuchuluka kwa shuga m'magazi mutatha kudya komanso m'mimba yopanda kanthu. Ndikofunikira kwambiri kuzindikira kuti siofor (mosiyana ndi zinthu zina za sulfonylurea) sizimalimbikitsa katemera wa insulin ndipo motero sizimayambitsa kuchepa kwambiri kwa glucose. Limagwirira a Siofor imayendetsedwa mbali zazikuluzikulu: kuponderezedwa kwa shuga mu chiwindi, kuchepa kwa zotumphukira minofu kukana insulin, ndikuchepetsa mayamwidwe a shuga m'matumbo ang'onoang'ono. Pogwira ntchito ya glycogen synthase, siofor imalimbikitsa kupangika kwa glycogen mkati mwa maselo ndikuwonjezera mphamvu pazonse zomwe zimadziwika za GLUT (zotulutsa shuga). Chinthu chinanso chabwino cha Siofor, chosayimira kuchuluka kwa shuga m'magazi, ndizothandiza zake pa metabolid metabolism, yomwe yatsimikiziridwa mobwerezabwereza m'mayesero azachipatala olamulidwa. Mankhwala amachepetsa kuchuluka kwa triglycerides, cholesterol yathunthu komanso otsika kachulukidwe lipoproteins.

Mlingo wa siofor umakhazikitsidwa payekhapayekha ndi endocrinologist malinga ndi kuchuluka kwa shuga wa plasma. Mankhwala a Siofor ayenera kuchitika ndi kuwonjezeka kosalala kwa mlingo kuchokera 500-850 mg mpaka pamlingo wambiri wa 3000 mg (pa avareji, tsiku lililonse la Siofor ndi 2000 mg).

Mankhwala amatengedwa ndi zakudya. Kutalika kwa nthawi ya maphunzirowa kumatsimikiziridwa ndi adokotala. Musanatenge Siofor, ndipo miyezi isanu ndi umodzi iliyonse ndikulimbikitsidwa kupimidwa ndikuwunikidwa kwa chiwindi ndi impso kuti agwire bwino ntchito. Kuwongolera kuchuluka kwa shuga wamagazi kumafunikiranso, makamaka pophatikiza siofor ndi zotumphukira za sulfonylurea. Pakati pa magulu ena a mankhwala omwe amatha kuyambitsa zotsatira za hypoglycemic ya mankhwalawa, mankhwala osokoneza bongo omwe amaletsa kutupa, monoamine oxidase inhibitors, angiotensin otembenuza enzyme inhibitors, ndi beta-blockers akhoza kudziwika. Ngati muphatikiza Siofor ndi mahomoni a chithokomiro, kulera kwapakamwa, glucocorticosteroids, ndiye kuti zotsutsana ndizotheka - kuchepa kwa zotsatira za hypoglycemic. Zambiri zokhudzana ndi kuchuluka kwa mankhwala osokoneza bongo sizikhala zopanda tanthauzo: kufooka, kupuma movutikira, kugona, kusanza, kutsekula m'mimba, kupweteka kwam'mimba komanso kuchepa kwa kuthamanga kwa magazi. Zikatero, chithandizo chamankhwala chimasonyezedwa.

Pharmacology

Hypoglycemic mankhwala ochokera pagulu la Biguanide. Amapereka kuchepa kwa magulu oyambira a glucose oyambira komanso a postprandial. Simalimbikitsa kubisalira kwa insulin chifukwa chake sikumabweretsa hypoglycemia. Machitidwe a metformin mwina amatengera njira zotsatirazi:

• kuchepa kwa shuga m'magazi chifukwa cha kuletsa kwa gluconeogeneis ndi glycogenolysis,
• kukulitsa chidwi cha minofu ku insulin, motero, kukonza zotumphukira zamafuta ndikugwiritsira ntchito,
• kuletsa kwamatumbo shuga.

Metformin, kudzera mu zochita zake pa glycogen synthetase, imapangitsa kaphatikizidwe ka glycogen. Zimawonjezera kuthekera kwamapuloteni onse a glucose membrane onyamula mpaka pano.

Mosasamala kanthu zazomwe zimachitika ndi glucose wamagazi, zimakhala ndi phindu pa metabolidi ya lipid, zomwe zimapangitsa kutsika kwa cholesterol yathunthu, cholesterol yotsika kwambiri komanso triglycerides.

Gwiritsani ntchito ntchito yolakwika yaimpso

Mankhwalawa amatsutsana ngati vuto la impso likulephera kapena aimpso (KK ®), ndikofunikira kusintha kwakanthawi ndimankhwala ena a hypoglycemic (mwachitsanzo, insulin) maola 48 asanafike komanso maola 48 atatha kufufuza kwa X-ray ndi iv yoyendetsedwa ndi othandizira ayodini.

Kugwiritsa ntchito mankhwalawa Siofor ® kuyenera kuyimitsidwa maola 48 isanachitike opaleshoni yomwe idakonzedwa pansi pa opaleshoni yayikulu, ndi msana kapena mankhwala opweteka. Mankhwalawa amayenera kupitilizidwa pambuyo poti ayambanso kudya pakamwa kapena osachepera maola 48 atachitidwa opaleshoni, malinga ndi chitsimikiziro cha ntchito yachilendo.

Siofor ® sichimalo mmalo mwa zakudya ndi masewera olimbitsa thupi tsiku ndi tsiku - mitundu iyi yamankhwala iyenera kuphatikizidwa mogwirizana ndi malingaliro a dokotala. Pa chithandizo ndi Siofor ®, odwala onse ayenera kutsatira zakudya zomwe zimadya thupi tsiku lonse. Odwala onenepa kwambiri ayenera kutsatira zakudya zamafuta ochepa.

Mayeso a labotale omwe ali muyezo kwa odwala matenda a shuga ayenera kuchitidwa pafupipafupi.

Musanagwiritse ntchito Siofor ® mwa ana a zaka zapakati pa 10 mpaka 18, kuwunika kwa matenda a shuga a 2 kuyenera kutsimikiziridwa.

Pakapita maphunziro azachipatala omwe adawongolera chaka chimodzi, zotsatira za metformin pakukula ndi chitukuko, komanso kutha kwa ana sizinawoneke, zambiri pazowonetsa izi pogwiritsa ntchito nthawi yayitali sizikupezeka. Pankhani imeneyi, kuwunikira mosamala magawo omwe ana akulandila metformin akulimbikitsidwa, makamaka munthawi ya prepubertal (zaka 10-12).

Monotherapy yokhala ndi Siofor ® siziwatsogolera ku hypoglycemia, koma kusamala kumalangizidwa mukamagwiritsa ntchito mankhwalawa ndi insulin kapena sulfonylurea.

Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu

Kugwiritsa ntchito kwa Siofor ® sikumayambitsa hypoglycemia, chifukwa chake, sikukhudza kuthekera koyendetsa magalimoto ndikusunga machitidwe.

Pogwiritsa ntchito munthawi yomweyo kugwiritsa ntchito mankhwalawa Siofor ® ndi mankhwala ena a hypoglycemic (sulfonylureas, insulin, repaglinide), chitukuko cha zochitika za hypoglycemic ndizotheka, motero, kusamala kumafunikira mukamayendetsa magalimoto ndi zochitika zina zoopsa zomwe zimafunikira chidwi ndi kuthamanga kwa zochitika zama psychomotor.