Melfor (Melfor)

Chifukwa cha kuthekera kotukuka kosangalatsa, kayendetsedwe ka kapisozi ndikulimbikitsidwa. Melfort m'mawa. Mlingo umayikidwa payekha kutengera zisonyezo ndi njira yoyendetsera.
Mukamwa, pakamwa limodzi ndi 0,25-1 g, kuchuluka kwa kayendetsedwe kake komanso nthawi yayitali ya chithandizo kumatengera zomwe akuwonetsa.
Ndi makina a iv, mlingo ndi 0.5-1 g 1 nthawi / tsiku, kutalika kwa chithandizo kumatengera zomwe zikuwonetsa.
0,5 ml ya jekeseni yankho ndi kuchuluka kwa 500 mg / 5 ml kutumikiridwa parabulbarly kwa masiku 10.

Contraindication

Contraindication kugwiritsa ntchito mankhwalawa Melfort ndi: kuchuluka kwazovuta zamkati (kuphatikiza pazovulala za venous outflow, zotupa za intracranial), mimba, mkaka wa m'mawere (ana oyamwitsa), ana ndi achinyamata osakwana zaka 18, kuchuluka kwa chidwi cha meldonium.

Kuchita ndi mankhwala ena

Akaphatikizidwa, meldonium imawonjezera ntchito ya antianginal mankhwala, mankhwala ena a antihypertensive, mtima glycosides.
Ndi munthawi yomweyo kugwiritsa ntchito meldonium ndi nitroglycerin, nifedipine, alpha-blockers, antihypertensive othandizira ndi zotumphukira vasodilators, tachycardia, ochepa hypotension ikhoza kukhala (ndi kuphatikiza uku, kusamala ndikofunikira).

Zizindikiro zogwiritsidwa ntchito

- Kuchepetsa magwiridwe antchito, kuchuluka kwa zochitika zolimbitsa thupi, nthawi yothandizira kuti ifulumizitse kukonzanso.

- Monga gawo la zovuta za matenda a mtima, kuchepa kwa mtima, Cardialgia motsutsana ndi maziko a sitormonal myocardial dystrophy.

- Monga gawo la zovuta za mankhwala amiseche yodziwika bwino (ngozi zakuwoneka za mtundu wa ischemic, makamaka gawo lachiwopsezo, kuperewera kwa mphamvu ya cerebrovascular).

- Chithandizo chovuta chothetsa mowa.

- pachimake retinal kufalitsidwa, hemophthalmus ndi retinal zotupa zosiyanasiyana etiologies, thrombosis chapakati retine mtsempha ndi nthambi zake, retinopathy zosiyanasiyana etiologies (kuphatikizapo matenda ashuga ndi matenda oopsa).

Momwe mungagwiritsire ntchito: Mlingo ndi njira ya chithandizo

Yankho la jakisoni

Kuchulukitsa kwamaganizidwe ndi thupi: kwamitsempha 500 mg (5 ml) kamodzi patsiku. Njira ya mankhwala ndi masiku 10-14. Ngati ndi kotheka, maphunzirowa abwerezedwa pambuyo pa masabata awiri ndi atatu. Kwa matenda amtima (monga gawo la zovuta mankhwala): mtsempha wa magazi 500-1000 mg (5-10 ml). Njira ya mankhwala ndi masiku 10-14.

Ischemic cerebrovascular ngozi, makamaka pachimake gawo (monga gawo la mankhwala): 500 mg mtsempha wa magazi (5 ml) 1 nthawi patsiku kwa masiku 7-10, ndiye kuti amatengedwa pakamwa.

Matenda osakwanira a cerebrovascular: 500 mg intramuscularly (5 ml) kamodzi patsiku. Njira ya mankhwalawa ndi masiku 10 mpaka 14, kenako amasintha pakamwa. Kusiya mowa mowa: mtsempha - 500 mg (5 ml) 2 pa tsiku. Njira ya chithandizo ndi masiku 7-10.

Maselo a minofu a fundus ndi retinal dystrophy: jakisoni wa 50 mg (0.5 ml) wa jekeseni imayendetsedwa kwa regobulbarly ndi subconjunctively kwa masiku 10.

Amamwa pakamwa, asanadye, chifukwa chosangalatsa kugwiritsa ntchito m'mawa.

Kuchuluka zolimbitsa thupi 250 mg 4 pa tsiku. Njira ya mankhwala ndi masiku 10-14. Ngati ndi kotheka, mankhwalawa amabwerezedwa pambuyo pa masabata awiri ndi atatu. Ochita masewera amayesedwa 500-1000 mg kawiri pa tsiku asanaphunzitsidwe. Kutalika kwa maphunzirowo pakukonzekera ndi masiku 14-21, panthawi ya mpikisano - masiku 10-14.

Ndi matenda amtima (monga gawo la zovuta mankhwala):

Khola angina pectoris - 250 mg katatu patsiku kwa masiku 3-4, ndiye kuti 250 mg katatu pa tsiku kawiri pa sabata kwa miyezi 1-1.5.

Myocardial infarction: mu pachimake nyengo - kudzera mkati, ndiye mkati mwa 500 mg patsiku, kugwiritsa ntchito mlingo wonse kamodzi kapena 2 pa tsiku.

Kulephera kwa mtima kosatha - 500-1000 mg kamodzi patsiku. Njira ya mankhwala ndi milungu 4-6.

Cardialgia kumbuyo kwa dishormonal myocardial dystrophy 250 mg 2 pa tsiku. Njira ya chithandizo ndi masiku 12.

Cerebrovascular ngozi: munthawi ya pachimake, kudzera m'mitsempha, ndiye 500 mg patsiku, makamaka mu theka loyamba la tsiku. Njira ya mankhwala ndi milungu 4-6.

Kusiya mowa mowa (monga mbali ya mankhwala ena) 500 mg 4 pa tsiku. Njira ya chithandizo ndi masiku 7-10.

Zotsatira za pharmacological

Chothandizira cha Melfora ndi meldonium - analog yopanga ya gamma-butyrobetaine, yomwe imachepetsa zochita za gamma-butyrobetaine hydroxynase. Muzochitika za ischemia, imabwezeretsa bwino momwe magwiridwe antchito a oxygen ndikuperewera kwake m'maselo. Limagwirira ntchito limazindikira kusiyanasiyana kwake zotsatira zake zamankhwala: kuwonjezeka kwa mphamvu, kuchepa kwa chizindikiro cha kupsinjika kwa malingaliro ndi thupi, kutseguka kwa minofu ndi chimbudzi chosavomerezeka.

Imakhala ndi mtima monga: kuwonongeka kwa pachimake kwa ischemic, kumachepetsa mapangidwe a necrotic zone, kufupikitsa nthawi yokonzanso. Ndi kulephera kwa mtima, kumawonjezera kuchepa kwa mtima, kumathandizira kulolerana, komanso kumachepetsa pafupipafupi matenda a angina. Mu pachimake komanso matenda a ischemic matenda amitsempha yamagazi amatulutsa magazi mozungulira ischemia, amathandizira kugawa magazi mokomera dera la ischemic. Kugwiritsa ntchito ngati mtima ndi dystrophic fundus matenda. Imakhala ndi mphamvu pa dongosolo lamkati lamanjenje ndipo imachotsera magwiridwe antchito amitsempha yamagetsi amodzi komanso odziyimira pawokha mwa odwala omwe ali ndi vuto la uchidakwa wokhala ndi matenda achire.

Zotsatira zoyipa

Thupi lawo siligwirizana (redness, zotupa pakhungu, kuyabwa, kutupa), dyspepsia, tachycardia, kuchepa kapena kuwonjezeka kwa kuthamanga kwa magazi, kukwiya sikuvuta.

Ndi mankhwala osokoneza bongo a Melfort, kutsika kwa magazi, kupweteka mutu, tachycardia, chizungulire, kufooka kwakukulu kumayamba. Kuchiza ndi chizindikiro.

Tulutsani mawonekedwe, ma CD ndi kapangidwe kake

Ma PC 5. - matumba otumphuka (1) - mapaketi a makatoni.
Ma PC 5. - mapepala otumphukira (2) - mapaketi a makatoni.
Ma PC 5. - matumba otumphukira (3) - mapaketi a makatoni.
Ma PC 5. - mapaketi a matuza (4) - mapaketi a makatoni.
Ma PC 5. - matumba a matuza (6) - mapaketi a makatoni.
Ma PC 5. - matumba otumphuka (10) - mapaketi a makatoni.
Ma PC 10 - matumba otumphuka (1) - mapaketi a makatoni.
Ma PC 10 - mapepala otumphukira (2) - mapaketi a makatoni.
Ma PC 10 - matumba otumphukira (3) - mapaketi a makatoni.
Ma PC 10 - mapaketi a matuza (4) - mapaketi a makatoni.
Ma PC 10 - matumba a matuza (6) - mapaketi a makatoni.
Ma PC 10 - matumba otumphuka (10) - mapaketi a makatoni.
30 ma PC - matumba otumphuka (1) - mapaketi a makatoni.
30 ma PC - mapepala otumphukira (2) - mapaketi a makatoni.
30 ma PC - matumba otumphukira (3) - mapaketi a makatoni.
30 ma PC - mapaketi a matuza (4) - mapaketi a makatoni.
30 ma PC - matumba a matuza (6) - mapaketi a makatoni.
30 ma PC - matumba otumphuka (10) - mapaketi a makatoni.
Ma PC 10 - Zopopera za polymer (1) - mapaketi a makatoni.
20 ma PC. - Zopopera za polymer (1) - mapaketi a makatoni.
30 ma PC - Zopopera za polymer (1) - mapaketi a makatoni.
40 ma PC. - Zopopera za polymer (1) - mapaketi a makatoni.
Ma PC 50. - Zopopera za polymer (1) - mapaketi a makatoni.
Ma PC 100 - Zopopera za polymer (1) - mapaketi a makatoni.

Zizindikiro zamankhwala

Kwa pakamwa kapena mtsempha wa magazi: monga mbali ya zovuta za matenda a mtima (kuphatikiza mu osewera), nthawi yothandizirana kuti ipititse patsogolo kukonzanso, matenda obwera chifukwa cha uchidakwa wophatikizana ndi mankhwala ZMA).

Mwa makonzedwe a parabulbar: kusokonezeka kwakukulu kwa magazi mu retina, hemophthalmus ndi zotupa za m'magazi osiyanasiyana a etiology, thrombosis ya chapakati kwamitsempha yam'mimba komanso nthambi zake, retinopathy yamitundu yosiyanasiyana (kuphatikizapo diabetes komanso hypertonic) - pokhapokha pakayendetsedwe ka parabulbar.

Mlingo

Pokhudzana ndi kuthekera kotukuka kotheka, ndikofunikira kuti muziigwiritsa ntchito m'mawa. Mlingo umayikidwa payekha kutengera zisonyezo ndi njira yoyendetsera.

Mukamwa, pakamwa limodzi ndi 0,25-1 g, kuchuluka kwa kayendetsedwe kake komanso nthawi yayitali ya chithandizo kumatengera zomwe akuwonetsa.

Ndi makina a iv, mlingo ndi 0.5-1 g 1 nthawi / tsiku, kutalika kwa chithandizo kumatengera zomwe zikuwonetsa.

0,5 ml ya jekeseni yankho ndi kuchuluka kwa 500 mg / 5 ml kutumikiridwa parabulbarly kwa masiku 10.

Malangizo apadera

Gwiritsani ntchito mosamala matenda a chiwindi ndi / kapena impso, makamaka kwa nthawi yayitali.

Pazaka zambiri pazachidziwitso cha infarction yokomera ndi kusakhazikika kwa angina m'madipatimenti a mtima imawonetsa kuti meldonium sakhala njira yoyamba yothandizira odwala pachimake coronary syndrome.

Kuyanjana kwa mankhwala osokoneza bongo

Akaphatikizidwa, meldonium imawonjezera ntchito ya antianginal mankhwala, mankhwala ena a antihypertensive, mtima glycosides.

Ndi munthawi yomweyo kugwiritsa ntchito meldonium ndi nitroglycerin, nifedipine, alpha-blockers, antihypertensive othandizira ndi zotumphukira vasodilators, tachycardia, ochepa hypotension ikhoza kukhala (ndi kuphatikiza uku, kusamala ndikofunikira).

Njira yamachitidwe

Mankhwalawa ndi analogue yochita kupanga ya γ-butyrobetaine. Imakhala ndi chidwi chachikulu pakuphatikizidwa kwa carnitine ndi kayendedwe ka mafuta acid kudzera m'makoma a cell, ndikulepheretsa kudziunjikira kwa zotumphukira za acetyl coenzyme ndi acyl carnitine m'maselo.

Pharmacodynamics ya mankhwala imaphatikizapo kuwonjezeka kwa magwiridwe antchito.

Mankhwalawa ischemia, mankhwalawa amatithandizanso kuyendetsa / kugwiritsa ntchito mpweya ndi maselo, kumalepheretsa kuyenda kwa ATP ndikuyambitsa glycolysis. Pochepetsa msambo wa carnitine, mankhwalawa amathandizira kufalitsa kwa gamma-butyrobetaine, yomwe imapangitsa. Pharmacodynamics ya mankhwalawa imaphatikizapo kuwonjezeka kwa magwiridwe antchito, kuchepetsa zotsatira za kupsinjika kwamthupi / m'maganizo, ndikusintha chitetezo chazinthu zanyumba / minofu.

Mu pachimake mitundu ya ischemia, mankhwalawa amalepheretsa kuchitika kwa myocardial ndi necrotic njira, komanso imathandizira kukonzanso. Kuphatikiza apo, limalowetsa dongosolo lamkati lamanjenje ndipo limapangitsa kuti magwiridwe ake azigwira ntchito pakumwa zakumwa.

Mankhwalawa amatengedwa kuchokera m'matumbo. Yake bioavailability ukufika 78%.

Pazitali kwambiri pambuyo pamlomo makonzedwe amawonedwa pambuyo pa 60-120 mphindi.

Pa biotransfform, mankhwalawa amapanga awiri metabolites m'thupi. Kuthetsa theka-moyo ndikuchokera 3 mpaka 6 maola. Mankhwalawa amachotseredwa ndi impso.

Kupanga ndi mawonekedwe a kumasulidwa

Pogulitsa, mankhwalawa amaperekedwa mu mawonekedwe a makapisozi ndi yankho la jakisoni.

Piritsi limodzi lili:

• yogwira chinthu (meldonium dihydrate) - 500 mg,
• zida zina: 27.2 mg wa mbatata wowuma, 10.8 mg wa colloidal silicon dioxide, 5.4 mg wa calcium stearate,
• thupi ndi kapisozi ndi 98% gelatin ndi 2% titanium dioxide.

Mkati mwa makapisozi mumakhala ufa wonyezimira wa hygroscopic.

Pogulitsa, mankhwalawa amaperekedwa mu mawonekedwe a makapisozi.

Njira yothetsera vutoli imayikidwa mu ma ampoules a 5 ml, omwe ali m'matumba a contour cell ndi makatoni.

Zotsatira zoyipa

Zotsatira zotsatirazi zamthupi la mankhwalawa ndizotheka:

• Matupi: zotupa, zotupa, redness (zosowa),
• Matumbo am'mimba: mawonetseredwe a dyspeptic,
• CNS: kukondoweza kwa zochitika zama psychomotor,
• CVS: kuchuluka / kuchepa kwa kuthamanga kwa magazi, tachycardia (m'malo osowa kwambiri).

Mukatha kugwiritsa ntchito mankhwalawa, zotupa zimatheka.

Kuyenderana ndi mowa

Yogwira pophika mankhwala amapukusidwa mkati mwa maola 12. Pambuyo panthawiyi, chiopsezo chosagwirizana ndi mankhwala ndi zinthu zina sichitha kapena chochepa kwambiri.

Malangizo ogwiritsira ntchito mankhwalawa samaletsa kuphatikiza ndi mowa. Komabe, ngati njira ya makonzedwe ake ikuchitika pofuna kuthana ndi matenda aliwonse a mtima kapena ngozi ya mtima, wodwala ayenera kupewa kumwa mowa. Izi zimachitika chifukwa cha chiwopsezo cha kuchepa kwa ntchito ya mankhwala. Kuphatikizanso komweku kungayambitse:

• mawonekedwe owopsa
• tachycardia ndi angina pectoris,
• dyspeptic zinthu
• kudumpha mu kuthamanga kwa magazi.

Mukamamwa mankhwalawo ndi mowa, kulumpha m'magazi kungayambike.

Tsiku lotha ntchito

Osapitilira zaka 4 kuchokera tsiku lopanga. Ndikoletsedwa kumwa ndi jakisoni, tsiku lotha lomwe lafika.

Nthawi zina, ngati mankhwalawo palibe kapena safunika chifukwa choponderezedwa, mutha kulabadira m'malo mwake.

Zothandiza kwambiri komanso zotchuka za izo ndi:

Chifukwa chosakhalapo pakayipa pakagwiridwe kake ndi ntchito yake, mankhwalawa amalandilidwa kwambiri ndi madokotala ndi odwala. Zimathandizira pakuwonjezera mphamvu ndikuwonjezera mphamvu.

Gennady Oprishchenko (wochiritsa), wazaka 40, Pushkino

Mitundu yonse iwiri ya mankhwalawa (makapisozi ndi yankho) imathandizanso chimodzimodzi pakubwera kwa zizindikiro za kusiya, zovuta zamagazi mu GM ndi ma pathologies ena. Odwala amakhutitsidwa ndi mtengo wotsika mtengo wa mankhwalawo komanso kusowa kwathunthu kwa zotsatira zoyipa.

Ekaterina Kolpakova (wochiritsa), wazaka 36, ​​Yaroslavl

Ndikupangira mankhwala osati anthu odwala, komanso anthu athanzi (othamanga) kuti azichita bwino. Zimawathandiza bwino akapanikizika ndi nkhawa komanso thupi. Zotsatira zoyipa pantchito yanga yonse sizinawoneke.

Stanislav Smirnov, wazaka 41, Ryazan

Mankhwalawa anathandiza mchimwene wanga kuti ayambenso kumwa mowa. Dotolo adatchulidwa kuphatikiza ndi mapiritsi ena. Tsopano m'baleyo ali ndi ntchito ndipo amakhala ndi moyo wathanzi.

Inga Stepanenko, wazaka 38, Sergiev Posad

Mankhwalawa adamwa chifukwa chakulephera kwa kufalitsa kwa chithokomiro. Mphamvu zabwino zimawoneka mwachangu, kusakhalapo kwa zotsatira zoyipa sikungakusangalatseni. Inde, ndipo mtengo wake ndi wokwera mtengo.

Ndemanga za wodwalayo

Dotolo anandiuza Melfor ngati lingaliro lotsika mtengo la mankhwala ena. Chifukwa chake adandifunsa - kuti ndipereke mankhwala kwa mtengo wotsika mtengo kapena wotchipa wakunja.Kodi ndichifukwa chiyani ndikafunika mtengo wogulitsa? Kwa miyezi ingapo tsopano, adalembera kwa ine ndipo pali zotsatira zina: zakhala zosavuta kuyenda, kuukira kwa angina sikuchitika. Mwambiri, ndimakondwera kwambiri ndi a Melfor. Tithokoze mwapadera kwa madokotala omwe amamvetsetsa kuti opuma pantchito sangakhale ndi ndalama zogulira mankhwala okwera mtengo ndikuwapatsa chisankho!

Kufotokozera kwapfupi

Analogue yanyumba ya minimronate ndi mankhwala a Melfor (the yogwira mankhwala meldonium) - mankhwala a metabolic omwe amathandizira kutuluka kwa kagayidwe kachakudya kagayidwe kachakudya ndikuwongolera mphamvu yamagetsi. Zimalepheretsa kulowa mu mitochondria kwamafuta aulere achilengedwe, potero kuchepetsa kuchepa kwa makutidwe ndi okosijeni kumapeto kwake. Zotsatira zimaletsa kayendedwe kazinthu zamafuta kudzera m'matumbo a cell, komabe, imagwira ntchito pankhaniyi posankha, osangodutsa mafuta amafuta ochepa. Ponena za omwe ali ndi unyolo wamfupi, amatha kulowa ma mitochondria mwaulere ndikupanga chilichonse chomwe angafune (choyamba, tikulankhula za makutidwe awo). Mosiyana ndi trimetazidine, Melfore samayambitsa kudzikundikira kwa mafuta ochepera-oxidised acid mkati mwa mitochondria. Poyerekeza ndi ischemia, mankhwalawa amabwezeretsa mulingo wosazungulira mu kayendedwe ka okosijeni kupita ku minofu ndikugwiritsanso ntchito m'malo operekera. Nthawi yomweyo, anaerobic glycolysis imakulirakulira. Mothandizidwa ndi melphor, vasodilator wa gamma-butyrobetaine akuyamba kubereka mwachangu. Mankhwala amasintha magwiridwe antchito, amachepetsa zizindikiro za kutopa kwakuthupi ndi psychoemotional overstrain, amasintha chitetezo cha mthupi, mothandizidwa ndi chitetezo chokwanira cha cellular ndi chamanyazi, ndipo amakhala ndi mtima. Mu kuwonongeka kwa ischemic pachimake pamtima, Melfor amachepetsa kukula kwa necrosis, imathandizira kukonzanso. Ndi kusakwanira kwa mtima ntchito, kumawonjezera contractility ya mtima minofu, bwino kulolerana zolimbitsa thupi, ndipo amachepetsa chiopsezo cha angina pectoris. Ndi ubongo ischemia, kusungunuka kumapangitsa magazi kuyenda mu ischemic foci, kuwongolera kutuluka kwa magazi makamaka kumadera a ischemic. Palibe amene angalephere kuzindikira phindu lomwe likuwoneka la kugwiritsa ntchito Melfor kwa pathologies a fundus (mtima ndi dystrophic).

Mankhwalawa atha kugwiritsidwanso ntchito pakuwonjezera zovuta kwa odwala omwe ali ndi vuto loledzera: kumayambitsa dongosolo lamkati lamanjenje ndikuwachotsa zovuta zomwe zimagwira m'malo mwake. Mndandanda wazotsatira zabwino za Melfor sizingokhala ndi izi: mwachitsanzo, mankhwalawa amawonetsa antioxidant, kupewa lipid peroxidation ndikuyambitsa ma antioxidants amkati, chifukwa chomwe zotsatira za kupsinjika kwa oxidative zimatha. Mu maphunziro azachipatala, kuthekera kwa Melfor kuwongolera moyenera ntchito za endothelium ndikuwongolera kamvekedwe ka mitsempha yamagazi kunatsimikiziridwa. Kuphatikiza apo, zidapezeka kuti mankhwalawa amakhalanso ndi zotupa zina: mwachitsanzo, amachotsa ma adrenal ndi angiotensin mtima spasms, ndikuchepetsa kwathunthu zotumphukira mtima. Kuphatikiza apo, kusungunuka kumawonjezera chidwi cha zimakhala kuti insulin, imayendetsa kagayidwe ka lipids ndi glucose.

Melfor amapezeka m'mitundu iwiri ya mapiritsi: makapisozi ndi yankho la jakisoni. Ndikofunika kumwa mankhwalawa m'mawa, monga zingakhale zosangalatsa. Mlingo umakhazikitsidwa ndi adokotala payekhapayekha. Malinga ndi malingaliro apakati pakumwa pakamwa, mlingo umodzi wa Melfor ndi 0,25-1 g, kuchuluka kwa kayendetsedwe kake komanso nthawi yayitali ya mankhwalawa kumatsimikiziridwa ndi mawonekedwe ake. Ndi mtsempha wa mtsempha, tsiku lililonse mankhwalawa ndi 0,5-1 g, kutumikiridwa pa nthawi. Parabulbar (kudzera pakhungu la m'munsi chikope) Melfor imayendetsedwa mu 0,5 ml kwa masiku 10. Pomaliza, ndemanga yofunika: monga kafukufuku wazachipatala komanso chidziwitso pochiza matenda osakhazikika a angina ndi chithokomiro chachikulu cha myocardial awonetsa, Melfor sakhala kusankha koyamba mu matenda a pachimake.

Pharmacology

Metabolism enhancer, gamma-butyrobetaine analogue. Imachepetsa gamma-butyrobetaine hydroxynase, imalepheretsa kaphatikizidwe ka carnitine ndi kayendedwe ka mautali amafuta ambiri kudzera mumitsemvu yama cell, komanso kumalepheretsa kudziunjikira kwamitundu yamafuta aciccarnitine ndi acylcoenzyme A.

Mikhalidwe ya ischemia, imabwezeretsa bwino momwe magwiritsidwe ntchito a mpweya ndikuperekera ma cell, imalepheretsa kuphwanyidwa kwa kayendedwe ka ATP, ndipo nthawi yomweyo imayambitsa glycolysis, yomwe imachitika popanda kugwiritsa ntchito mpweya. Zotsatira zakuchepa kwa ndende ya carnitine, gamma-butyrobetaine yokhala ndi masodilating amapangidwe kwambiri. Limagwirira ntchito limazindikira kusiyanasiyana kwake zotsatira zake zamankhwala: kuwonjezeka kwa mphamvu, kuchepetsa mphamvu ya kupsinjika kwa malingaliro ndi thupi, kutseguka kwa minofu ndi kusakhazikika pakulimbitsa thupi, mtima.

Pankhani ya kuwonongeka kwa pachimake kwa ischemic ku myocardium, kumachepetsa mapangidwe a necrotic zone ndikufupikitsa nthawi yokonzanso. Ndi kulephera kwa mtima, kumawonjezera kuchepa kwa mtima, kumathandizira kulolerana, komanso kumachepetsa pafupipafupi matenda a angina. Mu pachimake komanso matenda a ischemic matenda amitsempha yamagazi amatulutsa magazi mozungulira ischemia, amathandizira kugawa magazi mokomera dera la ischemic. Kugwiritsa kwa mtima ndi dystrophic matenda a fundus. Imakhala ndi kukhudzika kwa chapakati mantha dongosolo, amachotsa magwiridwe antchito a mantha amthupi mwa odwala omwe ali ndi uchidakwa woperewera.

Pharmacokinetics

Pambuyo pakumwa pakamwa, imatengedwa mwachangu kuchokera mumimba. Bioavailability pafupifupi 78%. C_max mu plasma zimatheka 1-2 mawola makonzedwe. Amapangidwa mthupi ndikupanga ma metabolites awiri akuluakulu omwe amatsitsidwa ndi impso. T_1/2 ndi maola 3-6 ndipo zimatengera mlingo.

Kugwirizana kwa Melfor ndi mankhwala ena

Chiwopsezo chokhala ochepa hypotension ndi tachycardia wolimbitsa thupi chimachitika chifukwa cha munthawi yomweyo Melfort ndi mankhwala otsatirawa:

• zotumphukira vasodilators,
• alpha adrenergic blockers,
• antihypertensive othandizira
• nifedipine
• nitroglycerin.

Kuphatikiza apo, akatengedwa limodzi ndi mtima glycosides, mankhwala osokoneza bongo, komanso mitundu ina ya antihypertensive mankhwala, zotsatira zawo zimayamba kutchulidwa.

Bongo

Pankhani ya kuchuluka Mlingo wa mankhwala, kumverera kwa kufooka, mutu ndi chizungulire, kukula kwa tachycardia, ndi kutsika kwa magazi kungachitike. Popeza mankhwalawa ali ndi poizoni wochepa, mawonekedwe onse osafunikira amapezeka msanga pambuyo pa chithandizo chamankhwala.

Migwirizano ndi magwiritsidwe akusungidwa

Alumali moyo wa mankhwala Melfor ndi miyezi 24 kuchokera tsiku lotulutsidwa. Sungani pamalo owuma komanso amdima osavutikira ana.

Kutentha kwa mpweya sikuyenera kupitirira + 25 digiri Celsius.

Mankhwala Melfor amapezeka mu mankhwala opangidwa ndi mankhwala. Mtengo wake wapakati ku Russia ndi 500-560 rubles.

Mu malo azachipatala aku Ukraine Mutha kugula mankhwala a Melfor pamtengo wa 200 mpaka 250 hryvnia.

Nthawi zina, ngati mankhwalawa Melfor ndi osayenera, kapena ngati sangathe kugwiritsa ntchito, muyenera kulabadira m'malo omwe amagwiritsidwa ntchito kwambiri.

Ma fanizo odziwika kwambiri a Melfora ndi awa:

• Magnikor - kukonzekera kochokera pa acetylsalicylic acid ndi magnesium hydroxide, omwe amawaganizira zochizira matenda a mtima mu mawonekedwe owopsa komanso osakhazikika,
• Pumpan - mankhwala okhala ngati madontho ndi mapiritsi othandizira odwala matenda oopsa, kulephera kwa mtima, arrhasmia ndi matenda ena amtima.
• Cordaflex - mapiritsi otumphukira okhala ndi chophatikizira chachikulu cha nifedipine. Mankhwalawa amapangidwira khola la angina pectoris, vuto la matenda oopsa, matenda a mtima, komanso matenda oopsa, omwe amakhala ndi zovuta zina,
• Corvitol - mapiritsi okhala ndi metoprolol. Amagwiritsidwa ntchito pochizira matenda a mtima, matenda amitsempha yamagazi, angina pectoris, hyperthyroidism, matenda oopsa, komanso mtima wama mtima.
• Kudesan ndi mankhwala osokoneza bongo monga madontho ndi mapiritsi otengera ubidecarinone. Zizindikiro zazikulu za kugwiritsidwa ntchito kwawo ndi matenda a mtima, kuchepa kwa mtima, arrhythmia, komanso nthawi yobwezeretsa pambuyo povutika ndi myocardial infarction,
• Amlipin ndi mankhwala osakanikirana omwe amachokera ku lisinopril ndi amlodipine, omwe amathandizira matenda a mtima ndi matenda oopsa oopsa.
• Bisoprol - mapiritsi ozikidwa ndi bisoprol fumarate, omwe cholinga chake ndi mankhwala a angina pectoris, kulephera kwamtima, komanso matenda oopsa.

Chifukwa chogwira ntchito kwambiri komanso kusapezeka kwa zotsatira zoyipa, mankhwalawa Melfor amalandila ndemanga zabwino kuchokera kwa odwala ndi madokotala. Zambiri zitha kumapeto kwa nkhaniyi.

Anthu omwe adamwa mankhwalawo kuti ali ndi phindu pa mkhalidwe wamtima wamthupi ndi machitidwe a magazi. Zimathandizanso kuti mphamvu zithandizire mwachangu komanso kuwonjezera mphamvu.

Ngati muli ndi chidziwitso cha mankhwala omwe mumagwiritsa ntchito mankhwalawa Melfor, onetsetsani kuti mukugawana malingaliro anu ndi alendo ena pamalowa, kusiya ndemanga.