MALANGIZO ogwiritsira ntchito mankhwala DIBICOR ®

Nambala yolembetsa: P N001698 / 01
Dzina la malonda akukonzekera: Dibicor ®
Dongosolo losavomerezeka padziko lonse lapansi: taurine
Fomu ya Mlingo: mapiritsi
KupangaPiritsi 1 ili:
ntchito:

taurine 250 mg
zotuluka: cellcrystalline cellulose 23 mg,
mbatata wowuma 18 mg, gelatin 6 mg, colloidal silicon dioxide
(aerosil) 0,3 mg; calcium yokhala ndi 2.7 mg.
taurine 500 mg
zotuluka: cellcrystalline cellulose 46 mg,
mbatata wowuma 36 mg, gelatin 12 mg, colloidal silicon dioxide
(aerosil) 0,6 mg; calcium owira 5.4 mg.

Kufotokozera: mapiritsi amitundu yoyera kapena yoyera, yozungulira, yosalala, yokhala ndi chiopsezo komanso mawonekedwe.
Gulu la Pharmacotherapeutic: metabolic wothandizira.
Code ya ATX: C01EB

ZOCHULUKA ZA PHARMACOLOGICAL

Mankhwala
Taurine ndi chinthu chachilengedwe chosinthana ndi miyala ya sulufule ya sulfure: cysteine, cysteamine, methionine. Taurine ili ndi zinthu zowononga komanso zoteteza khungu, zimakhudza bwino phospholipid kapangidwe ka cell membrane, ndipo imasinthasintha kusinthana kwa calcium ndi potaziyamu ayoni. Taurine ali ndi mphamvu ya inhibitory neurotransmitter, ili ndi antistress athari, imatha kuyang'anira kutulutsa kwa gamma-aminobutyric acid (GABA), adrenaline, prolactin ndi mahomoni ena, komanso kuwongolera mayankho awo. Kutenga nawo kaphatikizidwe kamapuloteni amtundu wa kupuma mu mitochondria, taurine imayendetsa njira za oxidative ndikuwonetsa katundu wa antioxidant, imakhudza ma enzymes monga cytochromes omwe akukhudzidwa ndi metabolism a xenobiotic osiyanasiyana.

Dibicor ® chithandizo cha mtima kuperewera kwa mtima (CCH) kumayambitsa kuchepa kwa msokonezo wam'magazi komanso kuzungulira kwa magazi: kuthamanga kwa diastoli ya intracardiac kumachepa, contractility ya myocardial imawonjezeka (kuchuluka kwa kuchepetsa komanso kupumula, mgwirizano ndi kupumula).

Mankhwala amachepetsa kuthamanga kwa magazi (BP) mwa odwala omwe ali ndi matenda oopsa ndipo samakhudza kuthamanga kwa magazi kwa odwala omwe ali ndi vuto la mtima ndi kuchepa kwa magazi. Dibicor ® imachepetsa mavuto omwe amabwera chifukwa cha kuchuluka kwa mtima wama glycosides ndi "odekha" othandizira calcium, ndikuchepetsa hepatotoxicity ya mankhwala antifungal. Zimawonjezera magwiridwe antchito nthawi yayitali.

Mu shuga mellitus, pafupifupi masabata awiri atayamba kumwa Dibicor ®, kuchuluka kwa shuga m'magazi kumachepa. Kuchepa kwakukulu kwa kuchuluka kwa triglycerides, mpaka pang'ono, kuchuluka kwa cholesterol, kuchepa kwa atherogenicity ya plasma lipids, adazindikiranso. Kugwiritsa ntchito mankhwala kwa nthawi yayitali (pafupifupi miyezi 6)
kukonza magazi am'maso mwanga.

Pharmacokinetics
Pambuyo pa limodzi mlingo wa 500 mg wa Dibicor, mankhwala ochitikira taurine mu mphindi 15 mpaka 20 amatsimikizika m'magazi,
kufika pazofunikira pambuyo pa maola 1.5-2. Mankhwala kwathunthu amachotsedwa mu tsiku.

Zisonyezero zogwiritsidwa ntchito:

kulephera kwamtima kwamitundu yosiyanasiyana,
mtima glycoside kuledzera,
mtundu 1 shuga
lembani matenda ashuga a 2, kuphatikiza ndi Hypercholesterolemia,
ngati hepatoprotector mwa odwala omwe amamwa mankhwala a antifungal.

Kutulutsa mawonekedwe ndi kapangidwe kake

Amapezeka m'mapiritsi: flat-cylindrical, oyera kapena pafupifupi oyera, ali ndi chiopsezo komanso chinsalu (250 mg - ma PC 10. M'matumba a matuza, paketi ya makatoni 3 kapena 6, ma 30 kapena 60 ma PC. M mitsuko yagalasi yakuda, mu Phukusi la makatoni 1 akhoza, 500 mg - 10 zidutswa chilichonse chodzaza matuza, muthumba la makatoni 3 kapena 6).

Zogwira ntchito: taurine, piritsi limodzi - 250 kapena 500 mg.

Zothandiza monga: mbatata wowonda, cellcrystalline cellulose, calcium stearate, colloidal silicon dioxide (aerosil), gelatin.

Mankhwala

Taurine - yogwira ntchito ya Dibikor - chinthu chachilengedwe chosinthana ndi sulufa wokhala ndi amino acid: cysteamine, cysteine, methionine. Ili ndi osmoregulatory komanso nembanemba yoteteza khungu, imathandiza pa kuphatikizika kwa phospholipid ka cell membrane, ndipo imathandizira kusintha kusinthana kwa potaziyamu ndi calcium ion muma cell.

Ili ndi mphamvu ya inhibitory neurotransmitter, ili ndi antioxidant ndi antistress athari, imayang'anira kutulutsidwa kwa GABA (gamma-aminobutyric acid), prolactin, adrenaline ndi mahomoni ena, komanso mayankho ake. Zimatenga nawo kaphatikizidwe kamapuloteni amtundu wa kupuma mu mitochondria, ndikofunikira kuti njira za oxidative zithandizire, ndipo zimakhudza ma enzyme omwe amayang'anira metabolism osiyanasiyana a xenobiotic.

Odwala omwe ali ndi matenda ashuga, pafupifupi masabata awiri atayamba chithandizo, kuchepa kwa shuga m'magazi kumawonedwa. Panalinso kuchepa kwakukulu kwa ndende ya triglycerides, pang'ono pochepera - atherogenicity ya plasma lipids, cholesterol level. Pakupita kwa nthawi yayitali (pafupifupi miyezi isanu ndi umodzi), kusintha kwamkati wamagazi kwamaso kumawonedwa.

Zotsatira zina za Dibikor:

kusintha kwa kagayidwe kachakudya njira mu chiwindi, mtima ndi zina zimakhala ndi ziwalo,
kuchuluka kwa magazi ndi kuchepa zovuta za cytolysis pamaso pa matenda oyipa a chiwindi,
Kuchepetsa msokonezo m'magawo ang'onoang'ono / akulu oyenda ndi magazi ndi mtima kulephera, komwe kumawonetsedwa mwa kuchepa kwa intastacardiac diastolic, kuthamanga kwa mphamvu ya mtima,
kutsika kwa hepatotoxicity ya mankhwala antifungal ophatikizika,
kutsika kwapakati pa kuthamanga kwa magazi ndi matenda oopsa, pomwe odwala omwe ali ndi vuto la mtima komanso kuchepa kwa magazi, izi sizikupezeka,
kuchepa kwakali konse kwamayendedwe oyipa omwe amabwera chifukwa cha kuchuluka kwa mtima wama glycosides komanso oletsa calcium pang'onopang'ono,
kuchuluka magwiridwe anthawi yolimbitsa thupi.

Malangizo ogwiritsira ntchito Dibikora: njira ndi mlingo

Dibicor iyenera kutengedwa pakamwa.

Malangizo othandizira malinga ndi zomwe akuwonetsa:

Kulephera kwa mtima: 250-500 mg 2 kawiri pa tsiku mphindi 20 musanadye, kutalika kwa mankhwala ndi masiku osachepera 30. Ngati ndi kotheka, tsiku ndi tsiku mlingo ukuwonjezeka mpaka 2000-3000 mg,
Mankhwala a mtima glycoside: osachepera 750 mg patsiku,
Type 1 shuga mellitus: 500 mg kawiri pa tsiku limodzi ndi insulin. Njira ya mankhwala ndi miyezi 3-6,
Type 2 shuga mellitus: 500 mg kawiri pa tsiku ngati mankhwala amodzi kapena osakanikirana ndi ena othandizira pakamwa.
Ngati mankhwala a hepatoprotective: 500 mg 2 kawiri pa tsiku kwa nthawi yonse yogwiritsa ntchito antifungal agents.

Kuyanjana kwa mankhwala osokoneza bongo

Taurine imawonjezera inotropic mphamvu ya mtima glycosides.

Ngati ndi kotheka, Dibicor itha kugwiritsidwa ntchito limodzi ndi mankhwala ena.

Mafanizo a Dibikor ndi awa: Taufon, ATP-long, Tauforin OZ, Tincture wa hawthorn, ATP-Forte, Vazonat, Ivab-5, Kapikor, Karduktal, Cardioactive Taurin, Mexico, Metamax, Metonat, Mildrocard, Milkardin, Neocardilok, Rimodok , Tricard, Trizipin, Trimet, Vazopro, Mildrazin, Mildronat.

Ndemanga za Dibicore

Malinga ndi ndemanga, Dibikor ndi chida chotsika mtengo komanso chothandiza. Amawonetsa kuti mankhwalawa amatha kulolera bwino, amasintha shuga mwachangu, amathandizira kuonjezera mphamvu, kukonza kukumbukira ndikuyenda bwino. Odwala ena sasangalala ndi kukula kwa mapiritsiwo, omwe amawapangitsa kuti ayambe kumeza.

Mlingo ndi makonzedwe

Mapiritsi a Dibicor amatengedwa pakamwa musanadye (nthawi zambiri mphindi 20 chakudya chisanafike). Ayenera kumezedwa yonse osatafuna komanso kumwa madzi ambiri. Mlingo wa mankhwalawa zimatengera momwe thupi limagwirira ntchito:

Kulephera kwa mtima - 250 kapena 500 mg kawiri pa tsiku, ngati kuli kotheka, muyezowo utha kuwonjezeka mpaka 1-2 g (1000-2000 mg) mu milingo ingapo. Kutalika kwa chithandizo chotere kumadziwika ndi zizindikiro za mtima kulephera, pafupifupi, ndi masiku 30.
Mtundu woyamba wa matenda a shuga 1 mellitus (wodalira insulin) - mapiritsi amatengedwa pamodzi ndi kuvomerezedwa kwa mankhwala a insulin pamankhwala a 500 mg 2 kawiri pa tsiku, kutalika kwa mankhwalawa kumachitika kuyambira miyezi itatu mpaka miyezi isanu ndi umodzi.
Type 2 shuga mellitus (osadalira insulini) - 500 mg kawiri pa tsiku ngati monotherapy kapena osakaniza ndi mankhwala ena ochepetsa shuga. Mlingo womwewo, mapiritsi a Dibicor amagwiritsidwa ntchito pa matenda ashuga omwe amawonjezera kuchuluka kwa magazi m'thupi (hypercholesterolemia). Kutalika kwa mankhwalawa kumatsimikiziridwa ndi dokotala payekhapayekha, kutengera magawo a labotale a carbohydrate ndi lipid metabolism.
Mtima glycoside kuledzera - 750 mg patsiku kwa 2-3 waukulu.
Kupewera kwa matenda oopsa a hepatitis mukamagwiritsa ntchito mankhwala antifungal - 500 mg kawiri pa tsiku nthawi yonse yoyendetsedwa.

Nthawi zambiri, nthawi ya mankhwala ndi mankhwalawa imatsimikiziridwa ndi adokotala pawokha.

Zotsatira zoyipa

Mwambiri, mapiritsi a Dibicor amalekeredwa bwino. Nthawi zina zimakhala zotheka kukhala ndi matupi amtundu wakhungu ndi mawonekedwe a pakhungu, kuyabwa kapena ming'oma (chotupa ndi chotupa chomwe chimawoneka ngati kutentha kwa nettle). Zotsatira zosagwirizana (angioedema Quincke edema, anaphylactic mantha) mutamwa mankhwalawa sizinafotokozedwe.

Malangizo apadera

Pamapiritsi a Dibicor, pali malangizo apadera angapo omwe muyenera kuwamvetsera musanayambe kugwiritsa ntchito:

Potengera zakumbuyo zakugawana ndi mtima glycosides kapena calcium blockers, Mlingo wa mapiritsi a Dibicor uyenera kuchepetsedwa pafupifupi kawiri, kutengera momwe wodwalayo amamvera ndi mankhwalawa.
Mankhwalawa angagwiritsidwe ntchito molumikizana ndi mankhwala a magulu ena a mankhwala.
Palibe chidziwitso chokhudza chitetezo cha mapiritsi a Dibicor pokhudzana ndi mwana yemwe akukula panthawi yomwe ali ndi pakati kapena khanda panthawi yoyamwitsa, chifukwa chake, muzochitika izi, kayendetsedwe kawo kabwino.
Mankhwala samakhudza kuthamanga kwa zochitika zama psychomotor kapena kuthekera kwa kutsitsidwa.

M'mafakisoni, mankhwalawa amaperekedwa popanda mankhwala. Ngati mukukayika kapena mafunso okhudza kugwiritsa ntchito mapiritsi a Dibicor, funsani dokotala.

Contraindication

Hypersensitivity mankhwala. Osakwana zaka 18
(kufunikira ndi chitetezo sichinakhazikitsidwe).
Gwiritsani ntchito pa nthawi yoyembekezera komanso nthawi yoyamwitsa
Sichikulimbikitsidwa kugwiritsa ntchito mankhwalawa panthawi yapakati komanso nthawi yapakati
yoyamwitsa chifukwa chosowa luso
ntchito odwala m'gulu ili la odwala.