Malangizo a Thioctacid - BV (Thioctacid - HR) kuti agwiritse ntchito

Thioctacid BV: malangizo ogwiritsa ntchito ndi kuwunikira

Dzina lachi Latin: Thioctacid

Code ya ATX: A16AX01

Yogwira pophika: thioctic acid (thioctic acid)

Wopanga: GmbH MEDA Production (Germany)

Sinthani mafotokozedwe ndi chithunzi: 10.24.2018

Mitengo muma pharmacies: kuchokera ku 1605 ma ruble.

Thioctacid BV ndi metabolic mankhwala okhala ndi antioxidant zotsatira.

Kutulutsa mawonekedwe ndi kapangidwe kake

Thioctacid BV imapezeka m'mapiritsi okhala ndi utoto wamafuta: wobiriwira chikasu, oblong biconvex (ma 30, 60 kapena ma PC. M'mabotolo amdima amdima, botolo limodzi mumtolo wa makatoni).

Piritsi limodzi lili:

• yogwira mankhwala: thioctic (alpha-lipoic) acid - 0,6 g,
• othandizira zigawo: magnesium stearate, hyprolose, Hyperose-mmalo otsika,
• makanema ophatikizira amakanema: titanium dioxide, macrogol 6000, hypromellose, varnish aluminium yozikidwa pa indigo carmine ndi utoto wa quinoline chikasu, talc.

Mankhwala

Thioctacid BV ndi metabolic mankhwala omwe amasintha trophic neurons, ali ndi hepatoprotective, hypocholesterolemic, hypoglycemic, ndi lipid-kuchepetsa.

Mankhwala omwe amagwira ntchito ndi thioctic acid, omwe ali m'thupi la munthu ndipo amaletsa antioxidant. Monga coenzyme, imatenga nawo gawo la oxidative phosphorylation wa pyruvic acid ndi alpha-keto acid. Limagwirira ntchito thioctic acid ali pafupi ndi michere ya michere ya B. Amathandizira kuteteza maselo ku poizoni wa zotsatira zoyipa zamagetsi zomwe zimachitika machitidwe a metabolic, komanso zimalepheretsa zinthu zina zakupha m'thupi zomwe zalowa m'thupi. Kuchulukitsa msanga wa amkaka antioxidant glutathione, kumayambitsa kuchepa kwa zizindikiro za polyneuropathy.

Mphamvu ya synergistic ya thioctic acid ndi insulin ndiwonjezere pakugwiritsa ntchito shuga.

Pharmacokinetics

Mafuta a thioctic acid kuchokera m'matumbo am'mimba (GIT) akaperekedwa pakamwa amachitika mofulumira komanso kwathunthu. Kumwa mankhwala ndi chakudya kumachepetsa mayamwidwe. C_max (kuchuluka kwa ndende) m'magazi am'madzi mutangotenga muyezo umodzi umatheka pambuyo pa mphindi 30 ndipo ndi 0.004 mg / ml. Mtheradi wa bioavailability wa Thioctacid BV ndi 20%.

Asanalowe kufalikira kwatsatanetsatane, thioctic acid imadutsa gawo loyambira kudzera mu chiwindi. Njira zazikulu za kagayidwe kake ndi oxidation ndi conjugation.

T_1/2 (theka-moyo) ndi mphindi 25.

Kutupa kwa Thioctacid BV yogwira ntchito ndipo ma metabolites amachitika kudzera mu impso. Ndi mkodzo, 80-90% ya mankhwalawa amachotsedwa.

Malangizo ogwiritsira ntchito Thioctacid BV: njira ndi mlingo

Malinga ndi malangizo, Thioctacid BV 600 mg imatengedwa pamimba yopanda kanthu, maola 0,5 asanadye kadzutsa, kumeza lonse ndikumwa madzi ambiri.

Mlingo woyenera: 1 pc. Kamodzi patsiku.

Popeza kupezeka kwa chipatala, pochizira mitundu yayikulu ya polyneuropathy, kukhazikitsidwa koyambirira kwa yankho la thioctic acid kwa mtsempha wa mtsempha wa magazi (Thioctacid 600 T) ndikotheka kwa masiku 14 mpaka 28, kutsatiridwa ndikusintha kwa wodwala tsiku lililonse chifukwa cha mankhwalawa (Thioctacid BV).

Zotsatira zoyipa

• Kuchokera mmimba: Nthawi zambiri - nseru, kawirikawiri - kusanza, kupweteka m'mimba ndi matumbo, kutsekula m'mimba, kuphwanya kwamva kukomoka,
• Kuchokera kwamanjenje: Nthawi zambiri - chizungulire,
• thupi lawo siligwirizana: kawirikawiri - kuyabwa, zotupa pakhungu, urticaria, anaphylactic mantha,
• kuchokera mthupi lonse: kawirikawiri kwambiri - kuchepa kwamagazi m'magazi, mawonekedwe a hypoglycemia mawonekedwe ammutu, chisokonezo, thukuta limawonjezeka, komanso kuwonongeka kwa mawonekedwe.

Bongo

Zizindikiro: motsutsana ndi maziko a mlingo umodzi wa 1040 g wa thioctic acid, kuledzera kwambiri kumatha kukhala ndi mawonekedwe ofanana ndi kugwidwa kofupikika, hypoglycemic chikomokere, kusokonezeka kwakukulu kwa acid-base usawa, lactic acidosis, kusokonezeka kwamagazi kwambiri (kuphatikizapo imfa).

Chithandizo: ngati mankhwala osokoneza bongo a Thioctacid BV akuwoneka kuti ali ndi mapiritsi 10 akulu, mwana woposa 50 mg pa kilogalamu imodzi ya kulemera kwake kwa thupi, wodwalayo amafunikira kuchipatala msanga poika chithandizo chamankhwala. Ngati ndi kotheka, mankhwala a anticonvulsant amagwiritsidwa ntchito, njira zadzidzidzi zofunika kukonza ziwalo zofunika.

Malangizo apadera

Popeza ethanol imakhala pachiwopsezo chotukuka kwa polyneuropathy ndipo imayambitsa kuchepa kwamankhwala othandizira a Thioctacid BV, kumwa mowa kumatsutsana kwambiri ndi odwala.

Pochiza matenda a shuga a polyneuropathy, wodwalayo ayenera kupanga zinthu zomwe zimatsimikizira kuti shuga ipezeka m'magazi.

Tulutsani mawonekedwe, ma CD ndi kapangidwe ka Thioctacid ® BV

Mapiritsi, utoto wokutidwa ndi chikasu wobiriwira, oblong, biconvex.

Othandizira: Hypertose wotsika - 157 mg, hyprolose - 20 mg, magnesium stearate - 24 mg.

Kuphatikizidwa kwa chovala cha filimuyi: hypromellose - 15,8 mg, macrogol 6000 - 4.7 mg, titanium dioxide - 4 mg, talc - 2.02 mg, alarnum varnish kutengera utoto wa quinoline wachikasu - 1.32 mg, alarnum varnish yozikidwa pa indigo carmine - 0,16 mg.

30 ma PC - mabotolo amdima amdima (1) - mapaketi a makatoni.
Ma PC 60. - mabotolo amdima amdima (1) - mapaketi a makatoni.
Ma PC 100 - mabotolo amdima amdima (1) - mapaketi a makatoni.

Kuyanjana kwa mankhwala osokoneza bongo

Pogwiritsa ntchito munthawi yomweyo Thioctacid BV:

• cisplatin - imatsitsa achire,
• insulin, pakamwa hypoglycemic othandizira - amatha kupititsa patsogolo ntchito zawo, motero, kuyang'anira kuchuluka kwa shuga wamagazi kumafunika, makamaka kumayambiriro kwa kuphatikiza mankhwala, ngati kuli kofunikira, kuchepetsa kwa mankhwala a hypoglycemic ndikololedwa.
• Mowa ndi metabolites - amachititsa kuti mankhwalawa afooke.

Ndikofunikira kuganizira za thioctic acid kumanga zitsulo ndikaphatikizidwa ndi mankhwala okhala ndi chitsulo, magnesium ndi zitsulo zina. Ndikulimbikitsidwa kuti kuvomerezedwa kwawo kuchedwe masana.

Ndemanga pa Thioctacide BV

Ndemanga za Thioctacide BV nthawi zambiri zimakhala zabwino. Odwala omwe ali ndi matenda ashuga amawonetsa kuchepa kwa shuga m'magazi ndi cholesterol, thanzi labwino motsutsana ndi maziko amagwiritsidwa ntchito mankhwalawa kwa nthawi yayitali. Chimodzi mwa mankhwalawa ndikutulutsidwa kwa thioctic acid mwachangu, komwe kumathandizira njira zama metabolic ndikuchotsa mafuta osakwaniritsidwa m'thupi, ndikusintha mafuta kukhala mphamvu.

Njira yothandiza yochizira imadziwika mukamagwiritsa ntchito mankhwalawa pochiza chiwindi, matenda amitsempha, komanso kunenepa kwambiri. Poyerekeza ndi analogues, odwala amawonetsa kuchepetsedwa kosafunikira.

Mwa odwala ena, kumwa mankhwalawo kunalibe chiyembekezo chozama chochepetsera cholesterol kapena kunathandizira kukulitsa urticaria.

Zotsatira za pharmacological

Mankhwala osokoneza bongo. Thioctic (α-lipoic) acid imapezeka m'thupi la munthu, pomwe imagwira ntchito ngati coenzyme mu phosphorylation wa oxidative wa pyruvic acid ndi alpha-keto acid. Thioctic acid ndi antioxidant wa amkati; malinga ndi kupangira kwamapangidwe amtunduwu, ali pafupi ndi mavitamini a B.

Thioctic acid imathandiza kuteteza maselo kuti asawonongedwe ndi ma radicals aulere omwe amapezeka munjira za metabolic, amathandizanso mankhwala ena omwe amapezeka m'thupi. Thioctic acid kumawonjezera ndende ya amkati antioxidant glutathione, zomwe zimabweretsa kuchepa kukula kwa zizindikiro za polyneuropathy.

Mankhwalawa ali ndi hepatoprotective, hypolipidemic, hypocholesterolemic, hypoglycemic effect, amakongoletsa ma trophic neurons. Machitidwe a synergistic a thioctic acid ndi insulin amachititsa kuti shuga agwiritsidwe ntchito kwambiri.

Kupanga, kufotokozera, mawonekedwe ndi kuyika kwa mankhwalawo

Mutha kugula mankhwalawa m'njira ziwiri:

• Kukonzekera kwa pakamwa "Thioctacid BV" (mapiritsi). Malangizo ogwiritsira ntchito akuti ali ndi mawonekedwe a convex, komanso chipolopolo chachikasu kapena utoto wonyezimira. Pogulitsa, mapiritsi oterewa amabwera m'mabotolo azidutswa 30. Zomwe zimagwira chida ichi ndi thioctic acid. Mankhwalawa amakhalanso ndizowonjezera pazinthu zamtundu wa hydroxypropyl cellulose, magnesium stearate, hydroxypropyl cellulose, hypromellose, macrogol 6000, mchere wa quinoline chikasu cha aluminium, titanium dioxide, talc ndi indigo carmine aluminium salt.
• Njira yothetsera "Thioctacid BV" 600. Malangizo ogwiritsira ntchito akunena kuti mawonekedwe amtunduwu wa mankhwalawa amapangira jakisoni wambiri. Yankho lomveka bwino ndi chikasu ndipo limapezeka mumagalasi amdima amdima. Gawo lake logwira ndi thioctic acid. Monga zinthu zina zowonjezera, madzi oyeretsedwa ndi trometamol amagwiritsidwa ntchito.

Pharmacology

Mthupi la munthu, asidi wa thioctic amagwira ntchito ya coenzyme, yomwe imakhudzana ndi okosijeni a phosphorylation a alpha-keto acid, komanso pyruvic acid. Kuphatikiza apo, ndi antioididant wamkati. Mwakugwiritsa ntchito kwake (biochemical), gawo ili lili pafupi kwambiri ndi mavitamini a B.

Malinga ndi akatswiri, thioctic acid imateteza maselo ku zinthu zoyipitsidwa ndi ma free radicals omwe amapangidwa nthawi ya metabolism. Zimathandizanso kuti mankhwala osokoneza bongo omwe adalowa m'thupi la munthu.

Katundu wa mankhwala osokoneza bongo

Kodi mankhwala a "Thioctacid BV 600 ndi ati? Malangizo ogwiritsa ntchito akuti thioctic acid amatha kuwonjezera kuchuluka kwa antioxidant amkati monga glutathione. Zotsatira zomwezo zimabweretsa kuchepa kwakukulu kwa zizindikiro za polyneuropathy.

Ndizosatheka kunena kuti mankhwalawa ali ndi hypoglycemic, hepatoprotective, hypocholesterolemic ndi hypolipidemic. Amathanso kukonza ma trophic neurons.

Zotsatira za synergistic za thioctic acid ndi insulin zimathandizira kugwiritsira ntchito shuga.

Contraindication

Chifukwa cha kusowa kwa chidziwitso chakugwiritsa ntchito chida ichi ndi maphunziro azachipatala, sizikulimbikitsidwa kuti aziisankhira amayi oyamwitsa ndi amayi oyembekezera.

Kodi ndizotheka kupatsa mwana mankhwala "Thioctacid 600BV"? Kugwiritsa ntchito mankhwalawa kwa ana ndi achinyamata ndizoletsedwa. Komanso, sayenera kugwiritsidwa ntchito ngati munthu sakhudzidwa ndi chilichonse.

Zotsatira zoyipa

Ndi makonzedwe amkati a mankhwala, wodwalayo atha kukhala osafunikira monga:

• thupi lawo siligwirizana monga zotupa ndi kuyabwa pakhungu, komanso urticaria,
• Zotsatira zoyipa za m'mimba (kutaya m'mimba, nseru, kupweteka komanso kusanza).

Ponena za mawonekedwe omwe angathe kubayidwa, nthawi zambiri amayambitsa:

• zotupa pakhungu, anaphylactic mantha ndi kuyabwa
• kupuma movutikira komanso kuwonjezeka kowopsa kwa kupanikizika (intracranial),
• magazi, kukokana, mavuto ammaso, komanso kutaya mtima pang'ono.

Milandu ya mankhwala osokoneza bongo

Ngati mulingo woyenera wa mankhwalawa utakulirakulira, wodwalayo amatha kukhala ndi zizindikiro monga kukomoka, lactic acidosis, kusokonezeka kwa magazi ndi kukomoka kwa hypoglycemic.

Mukawona zoterezi, muyenera kufunsa dokotala, komanso kusanza m'manja mwa womenyedwayo, mumupatseni ma enterosorbents ndi kutsuka m'mimba mwanu. Wodwalayo ayenera kuthandizidwanso mpaka ambulansi itafika.

Mlingo

Mapiritsi a 600 mg okhala ndi mafilimu

Piritsi limodzi lili

ntchito yogwira - thioctic acid (alpha lipoic) 600 mg,

zokopa: hydroxypropyl cellulose otsika-hydroxypropyl cellulose, magnesium stearate,

hypromellose, macrogol 6000, titanium dioxide (E 171), talc, quinoline chikasu (E 104), indigo carmine (E 132).

Mapiritsi, okhala ndiula achikasu-obiriwira, oboweka mawonekedwe ndi biconvex pamwamba.

Analogi ndi mtengo

Sinthani mankhwala ngati Thioctacid BV ndi mankhwala otsatirawa: Berlition, Alpha Lipon, Dialipon, Tiogamm.

Ponena za mtengo, zitha kukhala zosiyana kwa mitundu yosiyanasiyana ndi opanga. Mtengo wa piritsi la "Thioctacid BV" (600 mg) ndi pafupifupi ruble 1700 pazidutswa 30. Mankhwala mu mawonekedwe a yankho amatha kugulitsidwa ma ruble 1,500 (pazinthu zisanu).

Ndemanga za mankhwala

Monga mukudziwa, mankhwalawa "Thioctacid BV" adapangidwira anthu omwe ali ndi vuto lalikulu la metabolic. Ndemanga za odwala zokhudza piritsi ndi zazing'ono. Malinga ndi malipoti awo, chida ichi ndi chothandiza kwambiri. Koma mwatsoka, mapiritsi nthawi zambiri amayambitsa zovuta, zomwe zimawonekera mu mseru, urticaria, ndipo nthawi zina ngakhale mawonekedwe amtundu wotentha komanso kusintha kwaumoyo wa wodwalayo.

Tsopano mukudziwa zomwe mankhwalawa amatanthauza "Thioctacid BV 600". Malangizo ogwiritsira ntchito, mtengo wa mankhwalawa wafotokozedwa pamwambapa.

Ndemanga za mankhwala omwe atchulidwa sachoka odwala okhawo omwe amatenga mapiritsi ake, komanso omwe adayikidwa yankho la jakisoni.

Malinga ndi malipoti a anthu otere, mavuto obwera chifukwa chakupanga msambo wa mankhwalawa siachilendo. Komanso, samatchulidwa ngati mumamwa mapiritsi.

Chifukwa chake, titha kudziwa kuti "Thioctacid BV" ndi chida chothandiza kwambiri kupangira zizindikiritso za polyneuropathy zomwe zidayamba pambuyo pakumwa zakumwa zoledzeretsa kapena motsutsana ndi maziko a matenda osokoneza bongo.

Mankhwala

Pharmacokinetics

Ndi makonzedwe apakamwa, pamakhala kuyamwa mwachangu kwa thioctic (alpha-lipoic) acid m'thupi. Chifukwa chogawa mwachangu minofu, theka la moyo wa thioctic (alpha-lipoic) acid m'magazi a m'magazi ndi pafupifupi mphindi 25. Mkulu paz plasma ndende ya 4 μg / ml anayeza ndi 0,5 mawola pambuyo pakamwa makonzedwe a 600 mg a alpha lipoic acid. Kuchoka kwa mankhwalawa kumachitika makamaka kudzera mu impso, 80-90% - mu mawonekedwe a metabolites.

Mankhwala

Thioctic (alpha-lipoic) acid ndi antioxidant wamkati ndipo amagwira ntchito ngati coenzyme mu oxidative decarboxylation wa alpha-keto acid. Hyperglycemia yoyambitsidwa ndi matenda a shuga imatsogolera kudzikundikira kwa glucose pama protein a matrix amitsempha yamagazi ndikupanga zomwe akuti "zomaliza zopangidwa kwambiri ndi glycation." Njirayi imayambitsa kuchepa kwa magazi a endoneural hypoxia-ischemia, omwe amaphatikizidwa ndikuwonjezeka kwa kupanga ma free radicals okosijeni, komwe kumabweretsa kuwonongeka kwa mitsempha yotayika komanso kufooka kwa ma antioxidants monga glutathione.

Mlingo ndi makonzedwe

Tengani piritsi limodzi la Thioctacid 600BV kamodzi patsiku limodzi, mphindi 30 asanadye kaye koyamba.

Tengani pamimba yopanda kanthu, osafuna kutafuna ndikumwa madzi ambiri. Kuphatikizidwa ndi kudya kwa zakudya kumatha kuchepetsa kuchepa kwa alpha lipoic acid.

Kutalika kwa mankhwalawa kumatsimikiziridwa ndi dokotala aliyense payekhapayekha.

Zochita zamankhwala osokoneza bongo

Panali kuchepa mu mphamvu ya chisplatin pamene idaperekedwa pamodzi ndi thioctacid. Mankhwala sayenera kutumikiridwa pamodzi ndi chitsulo, magnesium, potaziyamu, nthawi yapakati pakati Mlingo wa mankhwalawa iyenera kukhala osachepera maola asanu. Popeza kuchepa kwa shuga kwa insulin kapena mankhwala opatsirana pakamwa kungalimbikitsidwe, kuyang'anira shuga wamagazi ndikulimbikitsidwa, makamaka kumayambiriro kwa mankhwala ndi Thioctacid 600BV. Pofuna kupewa zizindikiro za hypoglycemia, ndikofunikira kuyang'anitsitsa kuchuluka kwa shuga m'magazi.

Wogwirizira Sitifiketi Yoyang'anira

MEDA Pharma GmbH & Co KG, Germany

Adilesi ya bungwe yomwe imavomereza zomwe ogula akufuna pa mtundu wa zinthu ku Republic of Kazakhstan Kuyimira kwa MEDA Pharmaceuticals Switzerland GmbH ku Republic of Kazakhstan: Almaty, 7 Al-Farabi Ave., PFC "Nurly Tau", nyumba 4 A, office 31, tel. 311-04-30, 311-52-49, kulembera / fakisi 277-7732