Retinalamin: malangizo ogwiritsira ntchito, ma analogi ndi ndemanga, mitengo yamafesi ku Russia

Mitengo muma pharmacie opezeka pa intaneti:

Retinalamin ndi mankhwala ogwiritsira ntchito kachulukidwe ka matenda a ophthalmology omwe amasinthira kusintha kwa retinal komanso kagayidwe ka minyewa ya maso.

Kutulutsa mawonekedwe ndi kapangidwe kake

Retinalamin imapezeka mu mawonekedwe a lyophilizate pokonzekera yankho la makonzedwe a mu intramuscular and parabulbar: porous misa kapena ufa wamtundu woyera kapena wachikasu oyera (22 mg aliyense mu botolo la 5 ml, mu bullet pack ya 5 PVC aluminium / foil) 2 mapaketi).

Mu 1 botolo la lyophilisate muli:

• Zogwira ntchito: retinalamin (kapangidwe ka madzi osungunuka a polypeptide a retina a ziweto) - 5 mg,
• Zowonjezera: glycine (okhazikika).

Zizindikiro zogwiritsidwa ntchito

• Glaucoma wamalipiro oyambira
• Matenda a shuga
• Central retinal dystrophy, kuphatikizapo zoopsa ndi zotupa za m'matumbo,
• Pakatikati ndi potumphera tapetoretinal retinal abiotrophy,
• Matenda a Myopic (monga gawo la mankhwala ophatikiza).

Contraindication

• Central retinal dystrophy yovuta komanso yotupa ya etiology, yapakati komanso yopuma ya tapetoretinal abiotrophy - kwa ana osakwana chaka chimodzi,
• Matenda a Myopic, matenda ashuga retinopathy, adalipitsa glaucoma yoyamba - kwa ana ndi achinyamata osakwana zaka 18 (chifukwa chosadziwa zambiri zokhudzana ndi chitetezo ndi kugwiritsa ntchito bwino mankhwala)
• Hypersensitivity pazinthu zomwe zimapangidwa.

Pa nthawi yoyembekezera, kugwiritsa ntchito retinalamin kumapangidwa (palibe deta yotsimikizira chitetezo chovomerezeka).

Ngati ndi kotheka, ntchito pa mkaka wa m`mawere ayenera kusankha pa kuyamwitsa.

Mlingo ndi makonzedwe

Njira yothetsera ya retinalamin imayendetsedwa kudzera mu intramuscularly kapena parabulbarno.

Mlingo woyenera wa akulu:

• Wapakati komanso zotumphukira za tapetoretinal abiotrophy, chapakati retinal dystrophy yotupa ndi yovuta, matenda ashuga retinopathy: intramuscularly kapena parabulbarly kamodzi patsiku kwa 5-10 mg, nthawi yayitali ya mankhwala - masiku 5 mpaka 10, maphunziro achiwiri amatha ngati pakufunika miyezi 3-6,
• Makina owonekera otsegula makina otseguka: jakisoni wamitsempha kapena parabulbar amachitika nthawi 1 patsiku pa mlingo wa 5-10 mg, nthawi ya chithandizo ndi masiku 10, njira yachiwiri ikhoza kutumikiridwa pambuyo pa miyezi 3-6,
• Matenda a Myopic: parabulbarno kamodzi patsiku mlingo wa 5 mg, kumene - masiku 10, tikulimbikitsidwa kuphatikiza ndi mavitamini a B ndi angioprotective.

Mankhwalawa chapakati ndi zotumphukira tapetoretinal abiotrophy, chapakati retinal dystrophy yotupa ndi zoopsa etiology, ana ndi achinyamata ndi mankhwala jekeseni wa intramuscular kapena parabulbar 1 nthawi patsiku limodzi, malinga ndi zaka:

• Kuyambira chaka chimodzi mpaka zaka 5 - 2,5 mg aliyense,
• Kuyambira zaka 6 mpaka 18 - 2,5-5 mg aliyense.

Kutalika kwa mankhwalawa ndi masiku 10, ngati kuli kotheka, maphunzirowa abwerezedwa pambuyo pa miyezi 3-6.

Pamaso pa jakisoni, lyophilisate imapukusidwa ndi 1-2 ml ya sodium chloride ya 0,9% (ya ana ndi akulu), madzi a jakisoni kapena 0,5% yankho la procaine, kapena novocaine (akulu okha). Kuti tipewe kupindika, tikulimbikitsidwa kuti singano iwongoleredwe pobweretsa zosakanikirana kukhoma la vial.

Malangizo apadera

Njira yakonzayo singasungidwe; lyophilisate iyenera kuchepetsedwa ndi zosungunulira nthawi yomweyo musanabayidwe.

Palibe mawonekedwe a zochita za retinalamin pa mlingo woyamba kapena kumapeto kwa maphunzirowo.

Njira yothetsera vutoli iyenera kugwiritsidwa ntchito pokhapokha ngati dokotala wakupatsani.

Ngati mungalumphe jekeseni wotsatira, simungathe kulowa muyezo wapawiri, kuyendetsa kotsatira kumayenera kuchitika molingana ndi ndondomeko yanthawi zonse yogwiritsira ntchito mankhwalawa.

Yankho la retinalamin silikulimbikitsidwa kuti liphatikizidwe ndi mankhwala ena.

Chogwiritsidwacho sichikuwonongerani kutha kwamayendedwe ovuta, kuphatikizapo magalimoto.

Zotsatira zoyipa

Malangizowa amachenjeza za mwayi wokhala ndi zotsatirapo zoyipa mukamapatsa retinalamin:

• Thupi lawo siligwirizana munthu aliyense hypersensitivity zigawo zikuluzikulu za mankhwala.

Contraindication

Retinalamin imatsutsana mu milandu yotsatirayi:

• Mimba ndi nthawi yodyetsa (mbiri ya chitetezo cha gulu ili la odwala sichinaphunzire),
• Zaka mpaka 1 chaka (tapetoretinal abiotrophy (chapakati ndi chofiyira), chapakati cha retinal dystrophy cha kutupa ndi zowopsa) mpaka zaka 18 (kulipiritsa glaucoma yoyamba, diabetesic retinopathy, myopic matenda - mbiri yaku chitetezo cha m'badwo uno wa odwala sichinaphunzire),
• Hypersensitivity mankhwala.

Palibe deta pakumvana ndi mankhwala ena / mankhwala ena.

Bongo

Zambiri zosokoneza bongo siziperekedwa. Milandu yama bongo osokoneza bongo sanalembebe pano.

Kupanga ndi mawonekedwe a kumasulidwa

Retinalamin imayimilidwa ndi lyophilisate, yomwe imapangidwa ngati ufa wofanana wa khungu loyera kapena pafupifupi loyera, ndikofunikira pakukonzekera njira yothandizira achire. Njira yotsogolera mankhwalawa intramuscularly ndi parabulbar. Phukusi limodzi lili ndi mabotolo awiri kapena asanu. Khola achire zotsatira zimapereka mgwirizano wa zinthu zomwe zimapangidwa mu mankhwala a retinalamin:

ng'ombe retinal polypeptides (5 mg)

Zotsatira za pharmacological

Ndi othandizira kukonza minofu omwe ali ndi chidwi pakupanga maselo a retinal ndi ma photoreceptors, amathandizira magwiridwe antchito a zinthu za chipolopolo, ndikubwezeretsa kuwunikira kwa gawo lomwe lakhudzidwa ndi masomphenyawo. Mothandizidwa ndi ng'ombe retina polypeptides, kupindika kwamitsempha kumatha kusinthidwa mwachangu, kukula kwa zotupa kumachepetsedwa, ndipo njira zowonongera zimatha kuthamanga ngati vuto la retinal pathologies ndivulala.

Kuwunika kwathunthu kwa pharmacokinetic pazogwira ntchito sikungatheke. Mwa zina zabwino za mankhwala othandizirana ndi retinalamine, ndikofunikira kuchita izi pogwiritsa ntchito tizigawo ting'onoting'ono ta madzi a polypeptide okhala ndi kulemera kwakukulu kwa 10,000.

• Amasintha kagayidwe ka maselo amaso,
• imapangitsa kaphatikizidwe kabwino ka protein,
• imayendetsa ntchito ya nembanemba yama cell am'mimba,
• amalimbana bwino ndi kutukusira, njira za maselo,
• imayendetsa makulidwe a lipid oxidation,
• imapatsa retina mavitamini ofunikira,
• kumawonjezera kukongola kwamatha pambuyo pa maphunziro oyamba,
• imakweza njira zamagetsi.

Kuyanjana kwa mankhwala osokoneza bongo

Akatswiri aluso samalimbikitsa kuti asakanikize mayankho angapo mu botolo limodzi nthawi imodzi. Kuchokera pamankhwala oterewa, kufunikira kwa mankhwalawa kumachepa kwambiri, mavuto sayikidwa pambali. Mwanjira ina, kuyanjana kwa retinalamin muzochita sikunalembedwe mwatsatanetsatane mwatsatanetsatane sikuwonetsedwa.

Zotsatira zoyipa ndi bongo

Palibe zoyipa zomwe zidanenedwa ndi ana adotolo ndi othandizira, kapena sizinalembedwe ndi akatswiri a maso. Chosiyana ndi kukhudzika kwamphamvu kwa thupi kuzinthu zomwe zimapangidwa kuchokera ku retinalamin. Zotsatira zake, kuyanjana kwakanthawi kumachitika komwe kumakhalako kwakanthawi, kumafuna kuyimitsidwa kwa mankhwalawo kapena kusinthanitsa ndi analogi.

Migwirizano yogulitsa ndikusunga

Retinalamin ungagulidwe ku pharmacy popanda mankhwala, koma ungagwiritsidwe ntchito monga momwe dokotala wakupangira. Sungani ufa mu mbale m'malo owuma, amdima komanso ozizira. Onetsetsani kuti mwamaliza masiku oti zitha. Ngati mankhwalawo atha, ataya nthawi yomweyo, mugule ufa watsopano kuti mugwiritse jakisoni wa mu mnofu.

Pharmacodynamics ndi pharmacokinetics

Mankhwalawa ali ndi zovuta zosungunuka zamadzi tizigawo ta protein. Njira yamachitidwe Ndikukonza kagayidwe kamaso ka minyewa yamaso ndikusintha ntchito ya maselo. Mankhwalawa ali ndi phindu pa mapuloteni kaphatikizidwe, komanso amasintha njira mafuta oxidation, zimathandizira kuti kayendedwe ka kayendedwe ka mphamvu.

Sizotheka kuchita kusanthula kwa pharmacokinetic, chifukwa chophatikiza chophatikizika ndichovuta chonse cha zigawo za polypeptide.

Zomwe zimayikidwa

Retinalamin ndi bieptgator ya peptide yopangidwira kupangidwanso kwa minofu. Chofunikira chachikulu ndicho kuphatikizira magawo a nyama retinal polypeptide. Mankhwala amapezeka mu mawonekedwe a lyophilisate (ufa kuti athandizidwe). Amayendetsa intramuscularly kapena mu orbit (parabulbar).

Retinalamin imalimbikitsanso kapangidwe kake ka ma cell a retina ndi Photoreceptor. Ndi kusintha kwa dystrophic, mankhwalawa amathandizira kulimbitsa ubale pakati pa zigawo zakunja za photoreceptors ndi epithelium ya pigment, kubwezeretsa chidwi cha kuwala kwa retina. Kuphatikiza apo, retinalamin imabwezeretsanso kuchepa kwa mitsempha yamagazi ndikuthamangitsanso kudzipulumutsa kwa retina mu ma pathologies ake osiyanasiyana.

Mankhwala amamasulidwa mu mawonekedwe a ufa woyera kapena porous misa. Mu paketi imodzi mumabotolo asanu. Vial imodzi imakhala ndi 5 mg ya polypeptide madzi osungunuka am'mimba, komanso 17 mg ya glycine.

Chidacho chimamasulidwa ndi kampani yaku Russia "Geropharm". Mtengo wa phukusi limodzi ndikuchokera ku 3500 mpaka 4500 rubles, koma amodzi, monga lamulo, ndiokwanira mu maphunziro.

Zizindikiro ndi contraindication

Retinalamin imawerengedwa ngati chisonyezo chachikulu chokhazikitsidwa ndi retinal dystrophy. Ndi ophthalmologist yekha yemwe angadziwe kuyenera kwa mankhwala kuti apatsidwe mankhwala kutengera zomwe zimayambitsa matenda a dystrophy ndi pathologies okhudzana nawo.

Zisonyezero zakugwiritsa ntchito retinalamin mu ophthalmologists:

1. Matenda a shuga a retinopathy. Ndi matenda ashuga, zovuta za maso zimachitika kawirikawiri. Popanda chithandizo, matenda ashuga a retinopathy angayambitse khungu. Matendawa amapita pang'onopang'ono, koma pang'onopang'ono: mitsempha ya magazi imakhala yofooka, zotupa za m'mimba zimawonekera. Pankhaniyi, ntchito zowoneka zimasokonekera, zipsera zimapangidwa zomwe zimalimbitsa retina, zomwe zimayambitsa kuphwanya.
2. Pakatikati ndi zotumphukira za tapetoretinal abiotrophy. Matendawa amapezeka kawirikawiri ndipo amadziwika ndi kuphwanya kwa Photoreceptors. Nthawi zambiri, zoyambitsa abiotrophy ndimatengera kwa chibadwa. Masomphenya amatayika pang'onopang'ono, kuwonongeka kwamawonedwe kumadziwika. Ndi abiotrophy, kutayika kwathunthu kwamaso kumatha.
3. Post-zoopsa ndi yotupa chapakati retinal dystrophy. Zomwe zimayambitsa izi ndikuphwanya kwamkati mwa khungu. Ndi retinal dystrophy, ma photoreceptors amawonongeka, omwe amachititsa malingaliro a mitundu ndikuwona patali. Poyamba, matendawa ndi asymptomatic, koma mtsogolomo kuchepa kwamawonedwe owonekera, kupenyera kwakumaso ndikusintha mumdima kukuipiraipira.
4. Makina oyambira otseguka a glaucoma. Izi ndi zovuta za ma pathologies omwe amachititsa kuwonjezeka kwa kuthamanga kwa intraocular chifukwa chakuyenda bwino kwa chinyezi cha maso ndi kapangidwe kabwino ka mbali ya chipinda chamaso. Open angle glaucoma imapezeka kawirikawiri. Poyamba, matendawa amatuluka popanda chizindikiro. Zomwe zimayambitsa glaucoma sizinayambike.

Retinalamine mankhwala amapatsidwa mankhwala osiyanasiyana a retina. Mankhwalawa sathandiza mu matenda amtundu wa chifuwa ndi retinitis pigmentosa. Contraindication imaphatikizapo chidwi cha munthu payekha pazinthuzo, kutenga pakati komanso kuyamwa. Nthawi zambiri, odwala amalekerera bwino mankhwalawo, koma nthawi zina, matendawo amatha. Zotsatira zoyipa zimawonedwa ndi tsankho la munthu pazigawo zake.