Egipentin - kufotokoza mankhwala, malangizo, ntchito, ndemanga

Siyani ndemanga yanu

Chidziwitso Chaposachedwa Chosowa Chidziwitso, ‰

Zikalata zolembetsera EGIPENTIN

• LP-000879

• LP-000684

Webusayiti yovomerezeka ya kampani RLS ®. Ensaikulopediya yayikulu ya mankhwala osokoneza bongo ndi katundu wa mankhwala omwe amapezeka ku Russia Internet. Ndondomeko yamankhwala Rlsnet.ru imapatsa ogwiritsa ntchito malangizo, mitengo ndi mafotokozedwe a mankhwala, zowonjezera pazakudya, zida zamankhwala, zida zamankhwala ndi zina. Maupangiri a pharmacological akuphatikiza chidziwitso cha kapangidwe ndi mawonekedwe amamasulidwe, zochitika zamankhwala, zisonyezo zogwiritsidwa ntchito, contraindication, zotsatira zoyipa, kuyanjana kwa mankhwala, njira yogwiritsira ntchito mankhwala, makampani opanga mankhwala. Ndondomeko ya mankhwala ili ndi mitengo yamankhwala ndi mankhwala ku Moscow ndi mizinda ina ya Russia.

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Zinthu zina zambiri zosangalatsa

Maumwini onse ndi otetezedwa.

Kugwiritsa ntchito malonda pazinthu sikuloledwa.

Chidziwitsochi cholinga chake ndi akatswiri azachipatala.

Kufotokozera kwamachitidwe a pharmacological

Mankhwala othandizira antiepileptic. Kapangidwe kazomwe amapangira mankhwala ndi ofanana ndi GABA, yomwe imakhala ngati mkhalapakati wodziwika pakatikati wamanjenje. Makina a zochita za gabapentin amakhulupirira kuti ndi osiyana ndi anticonvulsants ena omwe amagwiritsa ntchito ma GABA synapses (kuphatikizapo valproate, barbiturates, benzodiazepines, GABA transaminase inhibitors, GABA uptake inhibitors, GABA agonists ndi GABA mankhwala osokoneza bongo. Kafukufuku wa in vitro awonetsa kuti gabapentin amadziwika ndi kukhalapo kwa malo atsopano omangika a peptide mu minyewa yamatumbo amtundu, kuphatikizapo hippocampus ndi ubongo wa cortex, womwe ungakhale wokhudzana ndi ntchito ya anticonvulsant ya gabapentin ndi zotumphukira zake. Makulidwe ochulukirapo a gabapentin samamangiriridwa ku mankhwala ena wamba ndi ma neurotransmitter receptors muubongo, kuphatikiza ndi GABAA-, GABAB-, benzodiazepine receptors, okhala ndi NMDA receptors.

Pomaliza, magwiridwe antchito a gabapentin sanakhazikitsidwe.

Mankhwala

Mankhwala othandizira antiepileptic. Kapangidwe kazomwe amapangira mankhwala ndi ofanana ndi GABA, yomwe imakhala ngati mkhalapakati wodziwika pakatikati wamanjenje. Makina a zochita za gabapentin amakhulupirira kuti ndi osiyana ndi anticonvulsants ena omwe amagwiritsa ntchito ma GABA synapses (kuphatikizapo valproate, barbiturates, benzodiazepines, GABA transaminase inhibitors, GABA uptake inhibitors, GABA agonists ndi GABA mankhwala osokoneza bongo. Kafukufuku wa in vitro awonetsa kuti gabapentin amadziwika ndi kukhalapo kwa malo atsopano omangika a peptide mu minyewa yamatumbo amtundu, kuphatikizapo hippocampus ndi ubongo wa cortex, womwe ungakhale wokhudzana ndi ntchito ya anticonvulsant ya gabapentin ndi zotumphukira zake. Makulidwe ochulukirapo a gabapentin samamangiriridwa ku mankhwala ena wamba ndi ma neurotransmitter receptors muubongo, kuphatikiza ndi GABAA-, GABAB-, benzodiazepine receptors, okhala ndi NMDA receptors.

Pomaliza, magwiridwe antchito a gabapentin sanakhazikitsidwe.

Pharmacokinetics

Gabapentin amatengedwa kuchokera m'mimba. Pambuyo kumeza Cmax gabapentin mu plasma imatheka pambuyo maola 2-3. Mtheradi bioavailability pafupifupi 60%. Kulandila nthawi yomweyo monga chakudya (kuphatikiza omwe ali ndi mafuta ochulukirapo) sikukhudza ma pharmacokinetics a gabapentin.

Gabapentin samanga mapuloteni a plasma ndipo ali ndi Vd ya 57.7 L. Odwala omwe ali ndi khunyu, kuchuluka kwa gabapentin m'madzi amchere ndi 20% ya plasma yolingana ndi plasma kumapeto kwa nthawi ya dosing.

Gabapentin amangochotseredwa ndi impso zokha. Palibe zizindikiro za biotransformation la gabapentin mu thupi la munthu. Gabapentin samalimbikitsa oxidases omwe amapezeka mu metabolism ya mankhwala. Kuchotsa kufotokozedwa bwino pogwiritsa ntchito mtundu wa mzere. T1 / 2 imakhala yodziyimira payekha pakapita maola atatu.

Kuvomerezeka kwa Gabapentin kumachepetsedwa mwa okalamba komanso odwala omwe ali ndi vuto laimpso. Mlingo wa kuwongolera mosalekeza, plasma ndi chilolezo cha impso cha gabapentin ndizofanana molunjika kupangira chilolezo chain.

Gabapentin amachotsedwa ku plasma ndi hemodialysis.

Kuzungulira kwa plasma gabapentin mwa ana kunali kofanana ndi akulu.

Gwiritsani ntchito pa nthawi yoyembekezera

Ndizotheka panthawi yoyembekezera pokhapokha ngati chiyembekezo chamankhwala chikuyembekezeka kupitilira mwana wosabadwayo (maphunziro okwanira komanso oyendetsedwa bwino mwa amayi apakati sanatengepo).

Gawo la FDA la mwana wakhanda ndi C.

Panthawi ya chithandizo, kuyamwitsa kuyenera kuyimitsidwa (gabapentin imadutsa mkaka wa m'mawere mukamwa).

Zotsatira zoyipa

Pa mbali ya dongosolo chapakati mantha ndi zotumphukira mantha dongosolo: amnesia, ataxia, chisokonezo, incoordination, maganizo, chizungulire, dysarthria, kuchulukitsidwa irritability mantha, nystagmus, kugona, maganizo nthenda, kugwedeza, khunyu, amblyopia, diplopia, hyperkinesia, cholimbikitsa, zofooketsa kapena kusowa kwa chidwi, paresthesia, kuda nkhawa, kudana, kusokonekera.

Kuchokera pamimba yodutsamo: kusintha kwa madontho a mano, kutsekula m'mimba, kudya kwambiri, mkamwa owuma, nseru, kusanza, kupweteka kwa m'mimba, kupweteka kwam'mimba, kapamba, kusintha kwa mayesero a chiwindi.

Kuchokera ku hemopoietic dongosolo: leukopenia, kuchepa kwa maselo oyera a magazi, thrombocytopenic purpura.

Kuchokera kupuma dongosolo: rhinitis, pharyngitis, chifuwa, chibayo.

Kuchokera ku minculoskeletal system: myalgia, arthralgia, mafupa a mafupa.

Kuchokera pamtima dongosolo: ochepa matenda oopsa, mawonetseredwe a vasodilation.

Kuchokera kwamikodzo dongosolo: kwamikodzo thirakiti matenda, kwamikodzo incinuence.

Zotsatira zoyipa: erythema multiforme, matenda a Stevens-Johnson.

Dermatological zimachitika: kukula kwa khungu, ziphuphu, kuyabwa, zotupa.

Zina: kupweteka kumbuyo, kutopa, kufalikira kwa edema, kusabala, asthenia, malaise, kutupa kwa nkhope, kunenepa kwambiri, kuvulala mwangozi, asthenia, matenda ofanana ndi chimfine, kusinthasintha kwa shuga m'magazi, mwa ana - kachilombo ka virus, otitis media.

Mlingo ndi makonzedwe

Mkati, ngakhale zakudya.

Postherpetic neuralgia: patsiku la 1 la mankhwala - 300 mg / tsiku kamodzi, patsiku la 2 - 1600 mg / tsiku (mu 2 mg waukulu), pa tsiku la 3 900 900 mg / tsiku (mu 3 mg waukulu). Ngati ndi kotheka, kuti muchepetse kupweteka muyezo wotsatira, mutha kuonjezera mpaka 1800 mg / tsiku (mu 3 mg wogawidwa).

Khunyu (monga chida chowonjezera): kwa odwala azaka zopitilira 12 - 900-1800 mg / tsiku (mu 3 waukulu). Mlingo woyambirira ndi 300 mg katatu patsiku, ngati kuli kotheka, onjezani mlingo mpaka 1800 mg / tsiku. Mlingo watsiku ndi tsiku sayenera kupitirira 3600 mg. Ana a zaka 3-12 - mlingo woyambirira wa 10-15 mg / kg / tsiku (mu 3 waukulu), mlingo wogwira umasankhidwa ndi kupereka gawo kwa masiku atatu.

Kwa ana a zaka 5 kapena kuposerapo, muyezo wogwira ndi 25- 35 mg / kg / tsiku, kwa ana a zaka zapakati pa 3-4 - 40 mg / kg / tsiku (mu 3-mgawo wogawika).

Kutalika kwapakati pakati pa Mlingo hakuyenera kupitirira maola 12.

Kuwonongeka kwa gabapentin ndi / kapena kuphatikiza kwina kwa mankhwalawo kumachitika pang'onopang'ono kwa nthawi osachepera sabata limodzi.

Odwala (opitilira zaka 12) omwe ali ndi vuto la impso (creatinine chilolezo chosakwana 60 ml / min) kapena odwala omwe amalandila chithandizo cha hemodialysis, mlingo umachepa. Ndi chilolezo cha osachepera 60 ml / mphindi - 900-3600 mg / tsiku, chilolezo cha 30-59 ml / mphindi - 400-1400 mg / tsiku, 15-29 ml / mphindi - 200-700 mg / tsiku, zosakwana 15 ml / tsiku mphindi - 100-300 mg / tsiku. Kwa odwala a hemodialysis, mankhwala ena owonjezera a hemodialysis ndi 125-350 mg pambuyo pa gawo lililonse la maola anayi a hemodialysis.

Kuchita ndi mankhwala ena

Kuyanjana kwakukulu pakati pa gabapentin ndi ma anticonvulsants ena (phenytoin, valproic acid, phenobarbital, carbamazepine), komanso njira zakulera za pakamwa zomwe zimakhala ndi norethisterone ndi / kapena ethinyl estradiol, sizinakhazikitsidwe.

Maantacidids amachepetsa bioavailability wa gabapentin (mu maphunziro pamene atengedwa ndi Maalox, bioavailability wa gabapentin adachepetsedwa ndi 20%, atatengedwa maola 2 atatenga Maalox, ndi 5%).

Cimetidine pang'ono amachepetsa kuchotsa kwa gabapentin.

Naproxen (pa mlingo wa 250 mg), mwachiwonekere, amachulukitsa kuyamwa kwa gabapentin (pa mlingo wa 125 mg) kuchokera 12 mpaka 15%. Gabapentin sichikhudza magawo a pharmacokinetic a naproxen. Kuchita kwakanthawi kwa mankhwalawa mu Mlingo wolimbikitsidwa sikudziwika.

Morphine (60 mg) atatengedwa maola awiri atatha kutora gabapentin (600 mg) adakulitsa AUC ya gabapentin ndi 44%.

Njira zopewera kugwiritsa ntchito

Gabapentin sayenera kulembedwa kwa odwala omwe ali ndi zaka zosakwana 12 ndi kuchepa kwaimpso (palibe maphunziro omwe adachitidwa). Chenjezo limaperekedwa kwa okalamba (kukhudzana ndi misempha yokhudzana ndi msambo nthawi zambiri, mlingo umayikidwa malinga ndi chilolezo cha creatinine).

Mukutenga gabapentin, simuyenera kuyendetsa magalimoto ndi kugwiritsa ntchito zida zapamwamba zomwe zimafuna chidwi chochulukirapo.

Malangizo apadera olembetsa

Akaphatikizidwa ndi morphine, ndikofunikira kuwongolera zovuta zomwe zikubwera kuchokera ku dongosolo lalikulu lamanjenje. Mlingo wa gabapentin ndi morphine amachepetsedwa pang'onopang'ono.

Gabapentin sayenera kumwedwa pasanadutse maola awiri mutamwa mankhwalawa.

Posankha mapuloteni mumkodzo pogwiritsa ntchito mayeso a Ames N-Multistix SG, zotsatira zabodza zabodza zitha kupezeka limodzi ndi kugwiritsidwa ntchito kwa gabapentin ndi anticonvulsants ena, motero tikulimbikitsidwa kugwiritsa ntchito njira zina.

Zizindikiro zogwiritsidwa ntchito

Chithandizo cha kupweteka kwa neuropathic kwa anthu azaka zopitilira 18, monotherapy ya kukomoka pang'ono komanso popanda kuchita kwachiwiri kwa akuluakulu ndi ana azaka zopitilira 12, monga chida china chowonjezera pakukhudza pang'ono komanso kwachiwiri kwa akulu ndi ana azaka zitatu ndi achikulire.

Zotsatira za pharmacological

Mankhwala othandizira antiepileptic. Kapangidwe kazomwe amapangira mankhwala ndi ofanana ndi GABA, yomwe imakhala ngati mkhalapakati wodziwika pakatikati wamanjenje. Makina a zochita za gabapentin amakhulupirira kuti ndi osiyana ndi anticonvulsants ena omwe amagwiritsa ntchito ma GABA synapses (kuphatikizapo valproate, barbiturates, benzodiazepines, GABA transaminase inhibitors, GABA uptake inhibitors, GABA agonists ndi GABA mankhwala osokoneza bongo.

Dzinalo Losayenerana

Mankhwala a INN - Gabapentin.

Egipentin (dzina ladziko lonse la Gabapentin) ndi mankhwala omwe amagwiritsidwa ntchito pochiza matenda a khunyu, limodzi ndi kugwidwa koopsa.

Mu gulu la padziko lonse la ATX, mankhwalawa ali ndi N03AX12.

Kutulutsa mafomu ndi kapangidwe kake

The pharmacological zotsatira zimatheka ndi kuphatikizidwa kwa gabapentin mu mankhwalawa. Kuphatikiza apo, kapangidwe ka mankhwalawa amaphatikizapo povidone, poloxamer, crospovidone, magnesium stearate, hydrolase.

Mankhwalawa amapezeka mu mawonekedwe a makapisozi, omwe aliwonse amaphatikizapo 300 mg ya mankhwala othandizira. Makapisozi amadzaza matuza 20 ma PC. 3 kapena 6 matuza amatha kunyamula mkatoni.

Momwe mungatenge paripentin?

Mankhwalawa amapangidwira pakamwa. Mlingo wofananira amasankhidwa poganizira zovuta za matendawo. Nthawi zambiri, mlingo wokwanira wa 300 mpaka 600 mg wa patsiku ndi wokwanira kuti umathandizenso. Ngati ndi kotheka, ikhoza kuwonjezeka mpaka 900 mg patsiku.

Mosamala kwambiri, mankhwala ayenera kugwiritsidwa ntchito ngati kuwonjezeka kwa ntchito ya khunyu chifukwa cha kuwonongeka kwa ubongo.
Mankhwalawa amapangidwira pakamwa.
Chithandizo cha odwala matenda a shuga mellitus, nthawi zambiri, amachitika mu Mlingo wochepetsedwa.

Kuchokera minofu ndi mafupa

Kugwiritsa ntchito Egipentin kumatha kupweteka. Nthawi zina, motsutsana ndi maziko akumwa mankhwalawo, maonekedwe a edema ndi kuuma kwa mafupa, tendonitis ndi nyamakazi zimawonedwa. Kuphatikiza apo, mankhwalawa amatha kupanga zofunikira zoyambirira za bursitis, contractures ya minofu ndi mafupa.

Matumbo

Matenda a tizilombo toyambitsa matenda a Egipentin ndiwakuti ndikugwiritsa ntchito mankhwalawa, magwiridwe antchito am'mimba amasemphana. Mankhwalawa amatha kuyambitsa stomatitis, gastroenteritis, glossitis, esophageal hernia, proctitis, etc. Mankhwalawa angayambitse kuchuluka kwa magazi m'mimba. Kuphatikiza apo, odwala nthawi zambiri amakhala ndi zodandaula za kupweteka kwam'mimba.

Hematopoietic ziwalo

Pogwiritsa ntchito Egipentin, thrombocytopenia, zizindikiro za kuchepa kwa magazi ndi matenda a mandira zimatha kuchitika.

Kugwiritsa ntchito Egipentin kumatha kupweteka.
Matenda a tizilombo toyambitsa matenda a Egipentin ndiwakuti ndikugwiritsa ntchito mankhwalawa, magwiridwe antchito am'mimba amasemphana.
Poyerekeza ndi kagwiritsidwe ntchito ka Egipentin, vuto la psychosis lingachitike.

Pakati mantha dongosolo

Kugwiritsa ntchito kwa Egipentin kungayambitse kuchepa kwa chidwi ndi mphamvu zamagulu amisempha. Kuphatikiza apo, gawo logwiritsira ntchito la mankhwalawa limatha kuyambitsa nkhope, kutsekeka kwa magazi ndi kusowa kwa magazi. Poyerekeza ndi kagwiritsidwe ntchito ka Egipentin, momwe mumakhala chisangalalo, kuyerekezera zinthu zina komanso kuukira kwa psychosis. Kuwonongeka kwa chidwi, kugona tulo masana komanso kusokoneza mgwirizano.

Kuchokera pamtima

Kupanga zotsatira zoyipa kuchokera pa kutenga Egipentin kuchokera ku mtima ndi kosowa kwambiri. Nthawi yomweyo, pamakhala chiwopsezo cha arrhasmia, vasodilation ndi kudumphira magazi.

Kutenga Egipentin kungayambitse cystitis komanso kusokonekera kwamikodzo.
Kuphatikiza apo, mankhwalawa angayambitse kukula kwa impso.
Kutengera komwe kumamwa mankhwalawa, kuoneka kwa mayankho osiyanasiyana, omwe akuwoneka ngati zotupa pakhungu, ndikotheka.

Kutengera komwe kumamwa mankhwalawa, thupi limatulutsa thupi, lomwe limafotokozedwa ngati zotupa pakhungu ndi kuyabwa, kutupa kwa minofu yofewa. Nthawi zina, anaphylactic zimachitika.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Kuchita bwino komanso chitetezo chogwiritsa ntchito mankhwalawa panthawi yomwe muli ndi pakati komanso mkaka wa m`mawere sichinatsimikizidwe, chifukwa chake, izi ndi zotsutsana ndi ntchito ya Egipentin.

Ukalamba si kuphwanya kugwiritsa ntchito mankhwalawa, koma kusintha kwa mankhwalawa kumafunikira kutengera momwe impso imagwirira ntchito.
Mankhwala angagwiritsidwe ntchito mankhwalawa khunyu ana oposa zaka 12.
Nthawi yokhala ndi pakati komanso mkaka wa m`mawere ndi contraindication pakugwiritsa ntchito Egipentin.
Ngati mumamwa kwambiri Egipentin, kutsekula m'mimba kumawonekera nthawi zambiri.
Egipentin amatha kuwonjezera kuchuluka kwa phenytoin m'madzi a m'magazi pogwiritsa ntchito magazi.

Kuyenderana ndi mowa

Mukamalandira mankhwalawa, mowa sayenera kumwa.

Mankhwala omwe amathandizanso ofanana ndi awa:

1. Neurinu.
2. Tebantin.
3. Gabagamm
4. Convalis.
5. Gabapentin.
6. Katena.
7. Gapantek et al.

Piritsi la Gabapentin. Khunyu Mpweya pa Marichi 16, 2016. Mtundu wa HD.

Wopanga

Mankhwalawa amapangidwa ndi Iberfar-Viwanda Pharmaceuticals.

Mapangidwe ofanana ndi Neurontin.
Monga njira ina, mutha kusankha Tebantin.
Ngati ndi kotheka, mankhwalawa amatha kusintha ndi Convalis.

Ndemanga za Egipentin

Svetlana, wa zaka 32, Chiwombankhanga

Kuyambira ndili mwana ndimadwala matenda a khunyu. Nthawi zambiri matendawa amakomoka, koma madotolo amatenga mankhwalawo ndikuleka. Pafupifupi zaka 3 zapitazo, adatenga pakati ndipo adataya mwana. Poona izi, kukomoka kudayambiranso. Dokotala adamuuza Egipentin. Ntchito mankhwalawa kwa miyezi 6. Ndine wokhutira ndi zotsatira zake. Sindinawone zotsatira zoyipa zilizonse, koma pang'onopang'ono kuchuluka kwa kogwiritsa kunachepa. Ngakhale kuti ndalama zomwe zalandilidwa zidayima, kwazaka zambiri sizinachitike.

Grigory, wazaka 26, Vladivostok

Ndinayesetsa kugwiritsa ntchito mankhwala ambiri kuti ndithane ndi khunyu. Kugwiritsa ntchito kwa Egyptin kumayikidwa ndi dokotala. Mankhwalawa sandiyenera. Kuyambira tsiku loyamba la makonzedwe, zotsatira zoyipa kuchokera m'matumbo am'mimba zidawonekera. Kupweteka m'mimba, kusanza, ndi kutsekula m'mimba kunandipangitsa kusiya kumwa mankhwalawa.

Zotsatira zoyipa

Pa mbali ya dongosolo chapakati mantha ndi zotumphukira mantha dongosolo: amnesia, ataxia, chisokonezo, incoordination, maganizo, chizungulire, dysarthria, kuchulukitsidwa irritability mantha, nystagmus, kugona, maganizo nthenda, kugwedeza, khunyu, amblyopia, diplopia, hyperkinesia, cholimbikitsa, zofooketsa kapena kusowa kwa chidwi, paresthesia, kuda nkhawa, kudana, kusokonekera.

Kuchokera pamimba yodutsamo: kusintha kwa madontho a mano, kutsekula m'mimba, kudya kwambiri, mkamwa owuma, nseru, kusanza, kupweteka kwa m'mimba, kupweteka kwam'mimba, kapamba, kusintha kwa mayesero a chiwindi.

Kuchokera ku hemopoietic dongosolo: leukopenia, kuchepa kwa maselo oyera a magazi, thrombocytopenic purpura.

Kuchokera kupuma dongosolo: rhinitis, pharyngitis, chifuwa, chibayo.

Kuchokera ku minculoskeletal system: myalgia, arthralgia, mafupa a mafupa.

Kuchokera pamtima dongosolo: ochepa matenda oopsa, mawonetseredwe a vasodilation.

Kuchokera kwamikodzo dongosolo: kwamikodzo thirakiti matenda, kwamikodzo incinuence.

Zotsatira zoyipa: erythema multiforme, matenda a Stevens-Johnson.

Dermatological zimachitika: kukula kwa khungu, ziphuphu, kuyabwa, zotupa.

Zina: kupweteka kumbuyo, kutopa, kufalikira kwa edema, kusabala, asthenia, malaise, kutupa kwa nkhope, kunenepa kwambiri, kuvulala mwangozi, asthenia, matenda ofanana ndi chimfine, kusinthasintha kwa shuga m'magazi, mwa ana - kachilombo ka virus, otitis media.

Mimba komanso kuyamwa

Maphunziro okwanira komanso owongoleredwa mosamala pa chitetezo cha gabapentin pa nthawi yoyembekezera komanso mkaka wa m'mawere mwa anthu sanachitike. Ngati ndi kotheka, ntchito pa nthawi ya pakati ndi mkaka wa m`mawere ayenera kuwunika mosamala zabwino zomwe zingachitike pakubwera kwa mayiyo ndi kuopsa kwa mwana wosabadwayo kapena khanda.

Gabapentin amachotseredwa mkaka wa m'mawere. Mukamagwiritsa ntchito mkaka wa m`mawere, mawonekedwe a gabapentin wakhanda samakhazikitsidwa.

Kuchita

Kuphatikizidwa ndi ma anticonvulsants, zotsatira zoyesa zamkodzo wa mkodzo wabodza zanenedwa. Kuti mudziwe mapuloteni mumkodzo, tikulimbikitsidwa kugwiritsa ntchito njira yodziwika yolimbitsa mpweya wa sulfosalicylic acid.

Pogwiritsa ntchito munthawi yomweyo maantacid, mayamwidwe a gabapentin kuchokera m'matumbo amachepa.

Pogwiritsa ntchito nthawi yomweyo ndi felbamate, kuwonjezeka kwa T1 / 2 ya felbamate ndikotheka.

Ndi kugwiritsa ntchito pamodzi, vuto la kuchuluka kwa phenytoin m'madzi a m'magazi lafotokozedwa.

Gwiritsani ntchito ana

Kuchita bwino komanso chitetezo cha mankhwala a ululu wa neuropathic mwa odwala omwe ali ndi zaka zosakwana 18 sizinakhazikitsidwe.

Mphamvu ndi chitetezo cha gabapentin monotherapy pochotsa kugwidwa kwakanthawi kwa ana osaposa zaka 12 ndi zina zowonjezera ndi gabapentin pothandizira pakukhudzidwa pang'ono kwa ana osaposa zaka 3