Pancreatic lipase > Matenda a shuga

Kuyesedwa kwa lipase kumayendetsedwa pamatenda omwe akuwoneka kuti ali m'matumbo. Tiyeni tiwone za enzyme yotchedwa lipase - ndi chiyani? Ndimagwira ntchito yanji mthupi yomwe imagwira, ndipo ndimatenda ati omwe amapatuka kuchoka pazomwe zimachitika pazotsatira zoyeserera?

Lipase ndi enzyme yopangidwa ndi ziwalo zina za thupi. Imasungunuka, kupatula ndikugaya zigawo zingapo zamafuta, komanso imagwiranso ntchito zina zingapo zofunika. Pancreatic lipase ndiyofunikira kwambiri. Zochita zake zimatha kuyesedwa ngati mafuta sakudya.

Enzyme "imagwira" limodzi ndi colipase (coenzyme) ndi ma acid acid. Amapangidwa, kuwonjezera pa mapapu, m'mimba, matumbo ngakhale maselo oyera oyera - maselo oyera amkati mwa chitetezo chathupi. Palinso zinthu monga "lingual lipase". enzyme yomwe imapangidwa pamkanda wamkamwa mwa akhanda chifukwa chamadongosolo oyamba a chakudya, ndiko kuti, kuwonongeka kwa mkaka wa m'mawere.

Pancreatic lipase

Mulingo wake m'magazi ndiwokwera kwambiri kuposa mulingo wamitundu ina ya lipase. Komabe, ndi pancreatectomy (kuchotsedwa kwa kapamba), ochepa mwa lipase adatsalabe chifukwa chobisalira ndi ziwalo zina. Pakayezetsa mkodzo, lipase nthawi zambiri imasowa. Pambuyo "pobadwa" mu kapamba, umalowa m'matumbo, pomwe umagwira ntchito yake yayikulu - kuphwanya mafuta. Pancreatic lipase imachita mbali yofunika kwambiri. Ndikutanthauza kuti magazi amaperekedwa, popeza kusintha kwa chizindikirochi kungathandize pakuwonetsa matenda ambiri. Ndi ziti, taganizirani pansipa.

Pancreatic lipase ndi enzyme yopangidwa ndi kapamba yomwe "imaphwanya" triglycerides mu glycerol ndi mafuta achilengedwe ambiri. Nthawi zambiri, umaphwanya bowa womwe umatulutsidwa kale ndi bile.

Lipase imagwira ntchito mthupi

Kuphatikiza pa kuwonongeka kwa mafuta, lipase imakhudzidwa ndi kagayidwe ka mphamvu, komanso imatenga nawo gawo la mayamwidwe a polyunsaturated mafuta acids komanso mavitamini ena - makamaka, A, D, E, K.

Hepatic lipase imayang'anira kupatsidwa kwa plasma lipids. Imalimbikitsa mayamwidwe a ma chylomicrons ndi ma kachulukidwe otsika a lipoprotein.
Gastric lipase imayang'anira ntchito yodzutsa mawonekedwe a mafuta a tributyrin.
Lingase lipase.

Lipase assay

Kusanthula kwa Lipase kumachitika pazochitika ziwiri:

Kuyesedwa kwa lipase yamagazi kumawerengedwa kuti ndiwothandiza kwambiri pakudziwika kuti ali ndi pancreatitis pachimake kuposa kuyesa kwa magazi kwa amylase. Komabe, pambuyo pake, milingo ya lipase ikhoza kuchepa. Ndi ma mumps osavuta (omwe amatchedwa "mumps"), mulingo wake umakhalabe woyenera komanso amawonjezeka pokhapokha ngati matendawa amakhudza kapamba. Izi ndizotheka ndi matenda owopsa a impso kapena matenda a impso, ngakhale izi zimatchulidwa kwambiri. Chifukwa chake, tidasanthula enzyme yotchedwa "lipase" - chomwe ili ndi zomwe imagwira m'thupi. Tikhalebe pa kuyezetsa magazi kwa lipase.

Momwe mungakonzekerere kusanthula?

Magazi amaperekedwa mosamala pamimba yopanda kanthu, mumatha kumwa madzi musanayesedwe. Pambuyo pa chakudya chomaliza, pafupifupi maola 8-12 ayenera kudutsa. Ndikwabwino kuchita izi musanamwe mankhwala kapena masabata awiri atachokapo. Ngati izi sizingatheke, musanapereke magazi, ndikofunikira kunena kuti ndi mankhwala ati omwe amagwiritsidwa ntchito.

Tsiku lisanatenge magazi, muyenera kumadya zakudya zopepuka - osanenepetsa mafuta, okazinga, zakudya zonunkhira, mowa, komanso kupewa kuchita masewera olimbitsa thupi. Ndikulimbikitsidwa kupereka magazi musanayambe maphunziro ena - fluorografia, radiology - kapena njira zolimbitsa thupi.

Mlingo wa lipase wamagazi

Chizindikiro cha matenda ambiri ndi lipase enzyme, yodziwika momwe amuna ndi akazi achikulire ali ofanana. Akuluakulu, ndiye kuti, anthu omwe afika zaka 18 - kuchokera ku 0 mpaka 190 mayunitsi. Mwa ana (mpaka zaka 17), zolembedwa za lipase za mayunitsi 0 mpaka 130 zimawonedwa kuti ndizovomerezeka.

Kodi kuchuluka kwa magazi lipase kumatanthauza chiyani?

Kodi kuchuluka kwa puloteni yotchedwa lipase kumatanthauza chiyani? Mulingo wazomwe zili mkati mwake zikuwonetsa kuti kapamba ali bwino, koma ngati zisonyezo zakwaniritsidwa, izi zitha kuwonetsa matenda:

Pachimake kapamba kapena kuchulukitsa kwa matenda aakulu.
Biliary colic.
Matenda a gallbladder.
Zovala zikondamoyo.
Kukhalapo kwa zotupa mu kapamba.
Kutulutsa kwa zikondamoyo zamiyendo (mwala kapena bala).
Intrahepatic cholestasis (ndi kuchepa kwa kayendedwe ka bile mu duodenum).
Pachimake matumbo kutsekedwa.
Mtsempha wamkati.
Peritonitis (kutupa kwa peritoneum).
Zilonda zam'mimbazi.
Kukongoletsa kwa dzenje.
Hepatic matenda, pachimake kapena aakulu.
Mapampu ("mumps"), ndikupereka kaphatikizidwe ka kapamba.
Matenda a metabolism, omwe nthawi zambiri amawonedwa ndi gout, shuga, kunenepa kwambiri.
Matenda a chiwindi.

Komanso nthawi zina lipase imadzuka ndikusakanizidwa ndikugwiritsa ntchito mankhwala kwakanthawi monga barbiturates, narcotic analgesics, indomethacin, heparin.

Pancreatic lipase imachulukanso ndi kuvulala kwa mafupa a tubular. Komabe, popeza kuwunika kwa lipase sikungapereke chidziwitso chofunikira pakuwonongeka kwa thupi, chizindikirocho sichimayang'aniridwa chifukwa cha kuphulika.

Koma ndi kuwonongeka kwa kapamba, kuwunika kwa lipase ndi amylase ndikofunikira kwambiri. Kuchuluka kwawo munthawi yomweyo ndi kulondola kwakukulu kumawonetsa momwe maselo amachitika m'maselo a gland. Munthawi yodwalayo, wodwala amakhala kuti wabwinobwino kwambiri kuposa msanga wa lipase.

Zomwe zimayambitsa kuchepa kwa magazi lipase

Ngati lipase itachepetsedwa, imanena mavuto monga:

Kukula kwa khansa iliyonse kupatula khansa ya pancreatic.
Kuchulukirapo kwa triglycerides, komwe kumachitika ndi zosayenera zakudya, makamaka kumwa kwambiri mafuta.
Kusintha kwa kapamba mpaka nyengo yovuta.

Lipase mu enzyme kukonzekera

Thupi lathu limatulutsa michere ya chakudya popukusa mapuloteni, mafuta ndi chakudya (zazikulu zomwe ndi amylase, lipase ndi proteinase). Komabe, pankhani ya kuchepa kwa kupanga kusakwanira), kapamba ndi matenda ena apakhungu, madokotala amalemba mankhwala omwe ali ndi michere ya nyama - ali mu nembanemba, motero amatetezedwa ku kuchuluka kwa acidity ya m'mimba. Kufika ku duodenum, adamulowetsa mmenemo. Enzymes nthawi zambiri amalembedwa m'mafupifupi maphunziro, koma nthawi zina mumayenera kumwa nthawi yayitali. Kugwiritsa ntchito kwa nthawi yayitali ma enzyme kumatha kutsagana ndi kuchepa kwa ntchito ya pancreatic, komabe, atasiya kumwa mankhwalawo, ntchito ya chiwalocho imabwezeretseka. Mwa michere ya pancreatic, Creon, Festal, Mezim, Pancreasim, Panzinorm ndi mankhwala ena, omwe amagwiritsidwa ntchito kwambiri ndi pancreatin. Muli proteinase, lipase, amylase. Mlingo wa lipase piritsi limodzi ndiwokwera kuposa mulingo wa ma enzyme ena. Izi ndichifukwa choti lipase, poyerekeza ndi ma enzyme ena, matendawa amapangidwa ndi thupi pang'ono. Popeza lipase imatsitsidwa m'thupi, zomwe zimapezeka m'mankhwala zimakhala zosachepera 10,000 magawo a ntchito (UNITS).

Kukonzekera kwa enzyme nthawi zambiri kumakhala kotetezeka kwa thupi. Nthawi zambiri amatenga gawo limodzi la mankhwalawa pochiza maantibayotiki, komanso ma pre- ndi ma probiotic, komanso mavitamini ndi mankhwala ena.

Lipase ndi imodzi mwazinthu zofunika kwambiri zosungunulira madzi m'thupi la munthu. yomwe imagwira ntchito yogawa mafuta. Kuphatikiza apo, lipase ndiyofunikira kuti mayamwidwe abwinobwino a mavitamini osungunuka a K, E, D, A komanso njira yopambana ya kagayidwe kamphamvu.

Tizilombo tambiri ndi ziwalo zimatulutsa lipase: chiwindi, mapapu, tiziwopsezo timatumbo tambiri m'matumbo ndi m'mimba, kapamba. Mwa makanda, ensa iyi imapangidwa mkamwa. Ili ndiye lotchedwa lingual lipase, lomwe limaphwanya mafuta mkaka wamawere. Ma Enzym opangidwa ndi tiziwalo tosiyanasiyana timasiyana pang'ono ndipo iliyonse imayang'anira kutembenuka kwa mitundu ina ya mafuta. Chofunika kwambiri ndi lipase yopangidwa ndi kapamba. Amatchedwa pancreatic.

Ntchito ya Lipase

Ntchito yayikulu ya lipase ndikuphika mafuta, kuphwanya ndi kupatula. Kuphatikiza apo, mankhwalawo amatenga nawo gawo pakukonzekera mavitamini angapo, mafuta achilengedwe a polyunsaturated, komanso mphamvu ya metabolism.

Pancreatic lipase yopangidwa ndi kapamba imakhala chinthu chamtengo wapatali kwambiri chomwe chimapangitsa kuti mafuta azikhala ndi nthawi komanso nthawi. Imalowa m'mimba mwa njira yogwiritsira ntchito prolipase, enzyme ina; pancreatic enzyme ina, colipase ndi bile acid, imadzakhala othandizira pazinthuzo.

Pancreatic lipase imaphwanyidwa ndi lipids yomwe imatulutsidwa ndi hepatic bile, yomwe imathandizira kuchepa kwa mafuta osaloledwa omwe amapezeka muzinthu zamagulu azakudya mu glycerol, mafuta achepetsa. Chifukwa cha hepatic lipase, mayamwidwe a otsika osalimba lipoprotein, ma chylomicrons, komanso kuchuluka kwa mafuta mu plasma ya magazi amawongolera.

Gastric lipase imalimbikitsa chidwi cha tributyrin, zinthu zosiyanasiyana zomwe zimagwiritsidwa ntchito zimaphwanya lipids zopezeka mkaka wa m'mawere.

Pali njira zina zomwe zimakhala ndi lipase mthupi, kwa akulu ndi abambo akulu, chiwerengero 0-190 IU / ml chizikhala chizizwitsa, kwa ana osakwana zaka 17 - 0-130 IU / ml.

Pancreatic lipase iyenera kukhala ndi 13-60 U / ml.

Kuchuluka kwa lipase

Ngati pancreatic lipase ikwera, ichi ndichidziwitso chofunikira mukamapanga matenda, chimakhala chidziwitso cha kukula kwa zovuta zina mu kapamba.

Matenda akulu amatha kuonjezera kuchuluka kwa zinthu, kuphatikiza khansa yapakhungu, colic, zilonda zapakhosi, chikhodzodzo, kupweteka kwa matenda a chikhodzodzo.

Nthawi zambiri, kuchuluka kwa lipase kumalankhula za cysts ndi pseudocysts mu kapamba, kutsekeka kwa chimbudzi ndi miyala, chilonda, intracranial cholestasis. Zomwe zimayambitsa matenda ndizotsatira zam'mimba ndizovuta kwambiri, peritonitis, kulephera komanso kupweteka kwa aimpso, kukonzanso kwa zilonda zam'mimba.

Kuphatikiza apo, kuchuluka kwa lipase kumakhala chiwonetsero:

kuyeretsa kwachigoba,
kagayidwe kachakudya
kunenepa
mtundu uliwonse wa matenda ashuga
mumps zowonongeka ndi kapamba,
nyamakazi
kupatsidwa ziwalo zamkati.

Vutoli nthawi zina limayamba ndi kugwiritsidwa ntchito kwa nthawi yayitali kwa mankhwala ena: barbiturates, narcotic mtundu analgesics, Heparin, Indomethacin.

Ndikotheka kuti kutsegula kwa pancreatic lipase kumachitika chifukwa cha kuvulala, mafupa a mafupa a tubular. Komabe, kusinthasintha kosiyanasiyana kwa zinthu zamagetsi m'magazi sikungaganizidwe kuti ndi chisonyezo chowonongeka.

Chifukwa chake, kusanthula kwa lipase sikufanana konse ndi njira yodziwira kuvulala kwamatenda osiyanasiyana.

Kodi matenda a lipase amakula ndi matenda ati?

Kafukufuku pama paramu a magazi a lipase akuyamba kukhala ofunikira kuzilonda zosiyanasiyana zamatenda am'mimba. Kenako kusanthula kwa enzymeyi ndikulimbikitsidwa kuti kuchitika pamodzi ndi kutsimikiza kwa kuchuluka kwa amylase, enzyme yomwe imalimbikitsa kuwonongeka kwa zinthu zokhuthala mu oligosaccharides. Ngati zikuwonetsa kuti zonsezi zikuwonjezeka kwambiri, izi zikuwonetsa kukula kwa njira yoopsa ya m'mapazi.

Mankhwala ndi matenda a wodwala nthawi zambiri, amylase ndi lipase sakhala okwanira nthawi imodzi, nthawi zambiri lipase imakhala yokwezeka kwambiri kuposa amylase.

Kafukufuku wa Laborator awonetsa kuti ndi njira yotupa mu kapamba:

kuchuluka kwa lipase kumangokulira kuchuluka kokha,
Zizindikiro sizimafika poti dokotala sangadziwe zowona zake,
matendawa amatha kukhazikitsidwa patsiku lachitatu.

Ndikofunikira kuzindikira kuti ndi puffness kwambiri, kuchuluka kwa chinthucho kumakhalabe kwabwinobwino, kuchuluka kwa enzyme kumawonedwa pamaso pa mafuta pancreatic necrosis. Mlingo wa ntchito ya lipase imachulukitsa pafupifupi katatu ndi hemorrhagic mawonekedwe a pancreatic necrosis.

High lipase imatha masiku 3-7 kuyambira kumayambiriro kwa kutukusira pachimake, chizolowezi chodziwika bwino cha zinthu chimawonedwa pokhapokha pa tsiku la 7-14th la matenda. Pamene encyme ya pancreatic idalumphira pamlingo wa 10 ndi kupitilira, kudalirika kwa matendawa kumawoneka kuti sikwabwino, makamaka ngati zamankhwala am'mwazi zawonetsa kuti ntchitoyi ikupitilira masiku angapo, sikuchepera katatu.

Kuwonjezeka kwachangu kwa pancreatic lipase indices kumakhala kwachindunji, kogwirizana kwambiri ndi zomwe zimayambitsa kusokonezeka. Acute pancreatitis amadziwika ndi kukula kwa enzyme 2-6 patatha maola ochulukirapo, patatha maola 12-30, lipase imafika pamtunda wambiri ndipo pang'onopang'ono imayamba kutsika. Pambuyo patatha masiku 2-4, ntchito ya thupilo imayamba bwino.

M'matenda oyambawa, kuwonjezereka pang'ono kwa lipase kumadziwika, pomwe matendawa amakula, kusintha kwa gawo lakukhululuka, kumachitika.

Zoyambitsa Low Lipase

Kukhazikika kwa ma neoplasms owopsa a gawo lililonse la thupi, osati matenda a kapamba okha, amatha kutsitsa kuchuluka kwa lipase. Komanso, zifukwa zake ziyenera kufunafuna kuchepa kwa ntchito ya pancreatic, matenda amtundu wokhala ndi njira yovuta kwambiri, yomwe imachitika chifukwa cha kuwonongeka kwa endocrine glands (matenda a cystic fibrosis).

Pambuyo pa opaleshoni yochotsa mankhwalawa kuti muchotse kapamba, wambiri wama triglycerides m'magazi, omwe adayambitsa kudya kosayenera ndi zakudya zamafuta ambiri, cholowa cham'thupi chatsika chimachepetsa mulingo wa chifuwa cha pancreatic. Nthawi zambiri, kuchepa kwa milomo ya lipase kumawonedwa ndikusintha kwa kapamba kuchokera ku mawonekedwe owopsa kupita ku mbiri.

Kusakhalapo kwathunthu kwa pancreatic lipase kumachitika ndi kuperewera kwa kupangidwa kwake.

Zomwe michere imasungidwa ndi kapamba zimafotokozedwa mu kanema munkhaniyi.

Kodi kuwonjezeka kwa magazi lipase kumasonyezanji?

Kuchokera pakuwona kufunikira, lipase yopangidwa ndi kapamba imatenga gawo lofunikira pakuwunika. Kusinthasintha kwa mulingo wake pakapangidwe ka seramu yamagazi mbali ina kapena mbali ina ndi chizindikiro cha kukhalapo kwa zovuta zina mu kapamba.

Kuwonjezeka kwa kuchuluka kwa enzyme kumawonedwa ndi:

pachimake kapamba, kapena kukokoloka kwa matenda,
Biliary colic
kuvulala kwachikondwerero
kukhalapo kwa zotupa mu kapamba,
Matenda a gallbladder,
mapangidwe a cysts kapena pseudocysts mu kapamba,
kufinya kwa kapamba ndi kansalu kapena mwala,
intrahepatic cholestasis,
pachimake m'mimba
matumbo,
peritonitis
kukonza kwa zilonda zam'mimba,
kuyeretsa kwamkati (kabowo),
pachimake kapena matenda a impso,
mumps, momwe kapamba amakhudzidwa.
zovuta zama metabolic zomwe zimachitika ndi matenda ashuga, kunenepa kwambiri kapena kutuwa,
matenda a chiwindi,
ntchito kwa nthawi yayitali mankhwala - makamaka, barbiturates, narcotic analgesics, heparin, indomethacin,
kupatsidwa ziwalo othandizira.

Nthawi zina, njira ya lipase activation imalumikizidwa ndi kuvulala kwina - mwachitsanzo, mafupa a mafupa. Koma pankhaniyi, kusinthasintha pamlingo wa enzyme m'mwazi sikungaganiziridwe ngati chizindikiro cha kukhalapo kwa kuwonongeka kwakuthupi. Pazifukwa izi, kuyesa kwa lipase sikumaganiziridwa pakupezeka kwa kuvulala kwamavuto osiyanasiyana.

Kudziwa milingo ya seramu lipase ndikofunikira kwambiri pachilonda chilichonse chazirala. Pankhaniyi, kuyezetsa magazi pazomwe zili ndi enzymeyi komanso kuwunika kwa amylase (enzyme yomwe imalimbikitsa kupasuka kwa starch mu oligosaccharides) ndi chidaliro chachikulu imawonetsa kukhalapo kwa dongosolo la pathological mu pancreatic tishu: zisonyezo zonse ziwiri ndizapamwamba kuposa zabwinobwino). Pakukonzanso momwe wodwalayo alili, ma enzymewa satembenukiranso nthawi imodzi: monga ulamuliro, mulingo wa lipase umakhalabe wokwezeka kwambiri kuposa msinkhu wa amylase.

M'maphunziro, zidapezeka kuti pancreatitis patsiku loyamba, milingo ya lipase imakwera pokhapokha pamiyeso yochepa kwambiri ndipo nthawi zambiri imafikira pamlingo womwe ungatheke kuti udziwe ngati uli ndi chidaliro chachikulu. Kwenikweni, kukhalapo kwa matendawa potengera zomwe zikuwonetsa ntchito za lipase kungathe kutsimikiziridwa pa tsiku lachitatu. Pankhaniyi, mfundo zina ziyenera kukumbukiridwa:

ndi matenda osiyanasiyana am'matumbo, milomo ya lipase imakhalabe yofananira,
kuchuluka kwapakati pa enzyme kumawonedwa pamaso pa mafuta pancreatic necrosis,
ntchito ya lipase imachulukitsa nthawi 3.5 ndi hemorrhagic mawonekedwe a pancreatic necrosis.

Mlingo wambiri wa lipase umapitirira kuyambira masiku atatu mpaka asanu ndi awiri kuchokera pachiwopsezo cha kutupa. Kutsika komweko kumachitika pokhapokha masiku 7-14.

Ndi kuwonjezeka kwa milomo ya lipase ya 10 kapena kupitilira apo, matulukidwe a matendawa amawoneka kuti ndi osayenera, makamaka ngati chochitikacho chimapitilira masiku angapo ndipo sichimatsika katatu pamiyeso yokhazikika.

Kuwonjezeka kwa milingo ya pancreatic lipase kumakhala ndi kutengera kwake kutengera chifukwa chomwe chinayambitsa:

Mwanjira yovuta kwambiri ya kapamba, kuchuluka kwa ma enzyme kumayamba kukwera patatha maola angapo (kuchokera pa 2 mpaka 6) pambuyo povunda kwa kanyumba. Pambuyo maola 12-30, imafika pamlingo waukulu ndikuyamba kutsika. Matenda a enzyme amasinthidwa patatha masiku 2-4.
Mu mawonekedwe a pancreatitis, kuwonjezeka kwapang'onopang'ono kwa milomo ya lipase kumayamba kulembedwa. Koma momwe matenda amakula, chizindikirocho chimabweranso mwakale.

Norm, kutsitsa ndi kuchuluka lipase m'magazi

Mwa ana ndi achinyamata ochepera zaka 18, lipase yodziwika bwino m'magazi (tikulankhula za mawonekedwe ake apamba) imachokera ku 0 mpaka 125-130 mayunitsi / ml. Akuluakulu, amayi ndi abambo, zomwe zili mu enzymeyi kuchokera pamitundu yotalika 0 mpaka 190 zimawonedwa ngati zabwinobwino.

Ngati kuchuluka kwa lipase kudapitilira, ndiye kuti izi zitha kutanthauza kukhalapo kwa matenda monga:

Pakreatitis
Pancreatic cysts ndi zotupa (kuphatikizapo zilonda),
Peritonitis
Zilonda zam'mimba
Bowel,
Mitsempha kapena minyewa yamtima,
Kulephera kwina
Khansa ya m'mawere
Matenda a gallbladder ndi biliary thirakiti, mwachitsanzo, cholecystitis
Biliary colic, intrahepatic cholestasis,
Matenda a Metabolic, mwachitsanzo, kunenepa kwambiri, matenda a shuga,
Kupukusa, chifukwa chomwe kapamba amakhudzidwanso.

Nthawi zina misempha ya lipase ya magazi imachulukirachulukira ndikuwonongeka kwakukuru kwa minofu. , mwachitsanzo, ndi mafuta onunkhira (opindika) a ziwalo zamkati, minofu, yokhala ndi mafupa.

Mankhwala ochulukirapo a lipase ochulukitsitsa omwe amapezeka ndimatenda oopsa a kapamba - 10-50 nthawi. Milandu idalembedwa pomwe mayesowo adawonetsa kuwonjezeka kwa lipase 200 nthawi zonse kuchokera ku chizolowezi. Mlingo wa enzyme m'magazi umafika pazofunikira zake patatha maola 2-6 kuchokera nthawi yoyamba kuukira, ndipo pambuyo maola 12-30 amayamba kuchepa pang'onopang'ono.

Pancreatitis yayikulu, kuchuluka kwa lipase kumatengera mtundu wa matendawa. Nthawi zambiri, zinthu zapamwamba kwambiri za enzyme zimapitilira kwa masiku 3 mpaka 7 kutomera. Kutsika kwapang'onopang'ono kwa lipase kumachitika kawirikawiri pakati pa masiku 7 mpaka 14. Ngati chifuwa chachikulu cha pancreatitis chikuwonjezeka nthawi 10, ndiye kuti matendawa amatenga matenda oopsa kwambiri, makamaka ngati matendawa akupitilira masiku angapo.

Monga lamulo, milingo ya lipase imachulukirachulukira ndikugwiritsa ntchito mankhwala monga indomethacin, heparin, narcotic analgesics, barbiturates, ndi njira zina zoletsa pakamwa.

Kutsika kwa lipase kumatha kuonanso kusokonezeka kwakukulu m'thupi . Izi zitha kukhala chimodzi mwazizindikiro za matenda otsatirawa:

Ntchito yakuchepa kwa kapamba,
Matenda a oncological a chiwalo chilichonse (kupatula cha kapamba palokha),
Cystic fibrosis (matenda obadwa ndi chibadwa omwe amayamba chifukwa cha kuwonongeka kwa tiziwalo ta endocrine),
Herederal hyperlipidemia (mafuta amitsempha yamagazi).

Nthawi zambiri, kuchepa kwa lipase kumawonetsa kuti pachimake pacreatitis chayamba kale kukhala mawonekedwe osakhazikika.

Lipase Assays

Miyezo ya lipase yamagazi imatsimikiziridwa ndi kusanthula. Kuwongolera kumaperekedwa ngati munthu akuvutika ndi ululu wa "lamba", pali matenda a kapamba, chiwindi ndi chimbudzi, kulephera kwa impso, zilonda zam'mimba, kutsekeka kwamatumbo ang'onoang'ono, uchidakwa. Kuyesedwa kwa lipase kumakhalanso kofunikira kwa iwo omwe adachitidwa opaleshoni ya ziwalo.

Kuyesa kwa magazi kwa lipase kumachitika ndi njira ziwiri: enzymatic ndi biochemical . Yoyamba imagwiritsidwa ntchito nthawi zambiri, chifukwa imakuthandizani kuti mupeze zotsatira mwachangu.

Ngati pali zolinga zingapo zosonyeza matenda monga kapamba, ndiye kuti mupeze vuto lozindikira, kuwonjezera pazomwe mulase ya lipase, kuyezetsa kumapangidwanso pazomwe amylase.

Magazi a lipase amaperekedwa kuchokera m'mitsempha m'mawa, pamimba yopanda kanthu. Kuti mawunikidwewo aperekedwe chithunzi, ndikofunikira kukana chakudya chamafuta maola 12 musanabadwe.

Ngati pancreatitis ikukayikiridwa, dokotala amakupangira kuyesedwa kwa lipase, komwe kumatsimikiza kuchuluka kwa puloteni iyi m'magazi.

Zikondamoyo zimatulutsa lipase panthawi ya chimbudzi. Enzyme imeneyi imathandizira matumbo kugwetsa mafuta. Zikondazo zikagundika, zimabisala.

Kuyesedwa kwa lipase kumatha kuwonetsa ngati misempha ya lipase ya magazi ndi yokwera. Mulingo wokwera ungathe kuwonetsa vuto ndi kapamba.

Dokotala wanu amathanso kutsimikizira kuchuluka kwa enzyme ina yotchedwa amylase pamodzi ndi kuyesa kwa lipase. Izi zitha kupereka chidziwitso chowonjezereka chomwe chithandizira kuzindikira vuto la pancreatic.

Ganizirani machitidwe, zotsatira ndi miyambo ya lipase m'magazi, komanso zomwe muyenera kuchita ngati lipase ndi yokwezeka.

Dokotala nthawi zambiri amakupangira kuyesedwa kwa lipase yamagazi ngati munthu ali ndi vuto la kapamba.

Zizindikiro zina zimaphatikizapo:

malungo
chopondapo mafuta
kusanza ndi kapena kusanza
kupweteka kwambiri kumtunda kwa m'mimba,
kugunda kwa mtima
kuwonda
kusowa kwa chakudya
kupweteka kumbuyo.

Dokotala wanu atha kuyitanitsa kuyesa kwa amylase pamodzi ndi kuyesa kwa lipase. Zotsatira zakuyesa kwa Amylase zitha kuwonetsa ngati munthu ali ndi matenda apamba.

Miyezo ya Amylase ikhoza kuwonetsa zovuta zotsatirazi:

kapamba kapena kutupira kwa kapamba, amene amakhala wopweteka kapena pachimake,
kutupa kwa ndulu,
matenda a celiac
matenda a impso
khansa ya kapamba.

Pambuyo pakuzindikira, dokotala amatha kugwiritsa ntchito mayeso a lipase ndi amylase kuti awone momwe wodwalayo alili.

Kodi kuwunika kwa lipase kumachitika bwanji?

Kuyesedwa kwa lipase kumachitika ngati kuyezetsa magazi kulikonse. Katswiri wa labu amakoka mtsempha wokhala ndi alendo. Kenako amasankha mtsempha, ndikuthira magawo pamalowo ndikutulutsa magazi kuchokera mu mtsempha.

Wothandizira labotaleyo ndiye kuti amatumiza zitsanzo zamagazi ku labotale, komwe milingo ya lipase imayezedwa ndikuwunikiridwa.

Nthawi yazotsatira zimadalira momwe zinthu ziliri. Funsani dokotala wanu pamene zotsatira zoyesa zakonzeka.

Momwe mungakonzekerere kusanthula?

Kukonzekera kuwunika kwa lipase yamagazi ndikochepa. Nthawi zambiri ndikofunikira kuyesedwa m'mimba popanda kudya kwa maola 8 mpaka 12, musanakayezetse magazi.

Munthu yemwe amamwa mankhwala aliwonse kapena othandizira ayenera kudziwitsa adokotala pasadakhale chifukwa zinthu zina zimasokoneza zotsatira zoyenera za mayeso a lipase. Dokotala angakulangizeni kuti musamwe mankhwala ena musanayesedwe.

Mankhwala otsatirawa angakhudze milingo ya magazi lipase:

codeine
kulera
thiazide okodzeya,
morphine.

Mitundu ya lipase m'magazi

Magawo azotsatira amapezeka malinga ndi izi:

zaka
mbiri yazachipatala
njira yoyesera

Chifukwa cha kusiyanasiyana, ndikofunikira kukambirana pazotsatira ndi dokotala. Zotsatira zomwezi zitha kuonetsa vuto mwa munthu m'modzi, koma khalani mwa mtundu wina.

Ma labotale akapereka zotsatira zoyeserera, milingo ya lipase nthawi zambiri imayezedwa m'magawo pa millilita yamagazi.

Mitundu ya lipase m'magazi:

Kuchulukitsa kwa kapamba kumapangitsa kuchuluka kwa lipase m'magazi mkati mwa maola 4-8. Magawoli amatha kukhala okwera mpaka milungu iwiri.

Miyezi yambiri ya lipase imatha kuwonetsanso zovuta zina, monga impso kapena matumbo.

Miseru yokhala ndi lipase yachilendo mwadzidzidzi imatha kuwonetsa mavuto osiyanasiyana.

Kodi kuchuluka kwa magazi lipase kumatanthauza chiyani?

Milingo yokwezeka ya lipase ikhoza kuwonetsa zinthu zingapo, monga:

pachimake kapamba
gastroenteritis ya gallstones, yomwe imachitika pamene kachilombo kamayambitsa kutupa m'mimba,
matumbo
cholecystitis kapena mwadzidzidzi kutupa kwa ndulu
matenda a celiac
matenda ammbuyo
khansa ya kapamba
kulephera kwa aimpso
mumps
peritonitis.

Kuchulukitsa kwa lipase ya m'magazi kungayambenso chifukwa chotenga mankhwala osiyanasiyana - maantibayotiki, ma analgesics, etc.

Kutanthauzira kwa zotsatira za kusanthula ndi kuwunika kuyenera kupangidwa ndi adokotala.

Kodi kuchepa kwa magazi lipase kumatanthauza chiyani?

Lipase yotsika kwambiri imatha kuwonetsa kuwonongeka kosatha kwa maselo a pancreatic omwe amapanga lipase. Izi zitha kukhala chifukwa cha kuphwanya kwanthawi yayitali, monga:

aakulu kapamba
cystic fibrosis.

Komanso, kuchepetsedwa kwa magazi lipase kungasonyeze:

chotupa mu ziwalo zosiyanasiyana,
peritonitis
kutupa ndi mitsempha ya ndulu,
zotupa ndi zotupa za kapamba,
zilonda zam'mimba zopangidwa, etc.

Momwe milili ya lipase imachepera

Kuti muchepetse lipase m'magazi, ndikofunikira kuchita zochizira matenda omwe adakula.

Acute pancreatitis ndi amodzi mwa mavuto omwe amabwera chifukwa cha kuthamanga kwa magazi m'magazi. Dokotala akapeza matenda am'mbuyomu, chithandizo chitha kuphatikizaponso:

jekeseni wa intravenous wa mankhwala
mankhwala a ululu
kukana kudya panthawi yoyenera, ndiye kudya kofewa.

Dokotala amathandizanso mavuto aliwonse omwe amayamba chifukwa cha kapamba, monga ma gallstones kapena calcium. Mankhwala ena amatha kuyambitsa pancreatitis yovuta kwambiri, pomwepo dokotala angasinthe mtundu wa mankhwala kapena mlingo.

Mutha kuchepetsa chiopsezo chokhala ndi pancreatitis pachimake pakudya zakudya zopatsa thanzi komanso zopewera kupewa komanso kumwa mopitirira muyeso.

Mankhwalawa atathandizira pazomwe zimayambitsa, milomo ya magazi lipase iyenera kubwerera mwakale.

Chiyeso cha lipase sichimazungulira ndipo sichingayambitse zovuta zina.

Zotsatira zakuyesa zitha kuthandiza dokotala wanu kuzindikira pancreatitis yachuma komanso mavuto ena azaumoyo omwe akukhudza kapamba wanu.

Kuzindikira ndi kuchiza pancreatitis pachimake kumayambiriro kumalepheretsa kuchepa kwaumoyo. Kuperewera kwa mankhwala a kapamba kumatha kupha.

Madokotala amalabadira kuyesedwa kwa magazi osati monga choncho . Pa magazi, mulimonse, kapena sichoncho, amawonetsedwa m'mayendedwe odziwika kwambiri. Lero tikambirana za matenda a kapamba omwe amatha kupezeka pogwiritsa ntchito enzyme yotchedwa lipase, kuchuluka kapena kuchepa kwa zomwe zikuwonetsa kuti chimbudzi sichikuyenda molingana ndi dongosolo .

Tisanafotokoze za lipase ngati enzy, ndikofunikira kufotokozera "ma enzyme" ndi chifukwa chofunikira. Ma enzyme (onaninso: enzyme) ndi molekyulu yapadera yomwe imaphwanya pawiri ya mankhwala m'magulu osavuta. Pali ma enzyme ambiri, ndipo aliyense wa iwo ali ndi udindo wa molekyulu inayake yomwe imafunika kugawanika. Zikuwoneka ngati zokumbira mamolekyulu: mwachitsanzo, ngati madzi amawoneka ngati lalikulu ndi mabwalo awiri (1 molekyulu ya hydrogen ndi mamolekyulu a 2 a oksijeni), ndiye kugawaniza kwa enzyme kumawoneka ngati kupumula kwa lalikulu limodzi ndi mabwalo awiri. Izi zikufotokozera kuti enzyme inayake ikhoza kugwetsa mtundu umodzi wofanana wa mamolekyulu: ena sioyenera kuumba.

Pambuyo pakuwongolera bwino, enzymeyo imasiya zinthu zowola kupita kwina ndikuyang'ana "wotsatira" wotsatira.

Lipase ndi dzina wamba la gulu la ma enzymes (tikambirana mitundu imodzi ya anthu m'gawo lotsatira). Ntchito za Lipase: kuwonongeka kwa mafuta, mankhwala a phosphorous ndi mavitamini ena. Lipase imapangidwa ndi minyewa yambiri yamthupi, koma zikondamoyo ndizo zimakhala zochuluka. Kumbuyo kwake, malingana ndi "mtundu" wake ndi chiwindi, chiwindi: mapapu, malovu, matumbo. Mlingo wa lipase m'magazi: kuyambira 0 mpaka 190 mayunitsi / lita.

Mitundu ya Lipase

Lipase agawidwa kukhala:

Lipoprotein lipase. Mtunduwu umapangidwa ndi minofu yambiri, kuphatikiza kwakukulu kumatha kupezeka mu mtima, minofu ndi minyewa ya adipose. Lipoprotein lipase imaphwanya lipids (mafuta) ozungulira m'magazi. Ngati lipase yamtunduwu sikokwanira, wodwalayo amakhala pachiwopsezo cha atherosulinosis, chifukwa mafuta osakhazikika amakhala pamakoma amitsempha yamagazi.
Pancreatic lipase. Enzyme iyi ndi yofunika kwambiri pakati pa lipases, imapangidwa ndi kapamba ndipo imalowa m'matumbo, pomwe imaphwanya mafuta. Matenda a pancreatic amatsogolera pakupanga enzyme yopanga, ndipo imayamba kulowa m'magazi, omwe amawonetsedwa pakuwunika.
Hepatic lipase. Izi lipase mu kachitidwe kake imakhala yofanana ndi pancreatic, koma salowa m'matumbo, koma nthawi yomweyo m'magazi. Pamodzi ndi lipoprotein lipase, amaswa mafuta omwe amayenderera m'magazi.
Phospholipase. Mtunduwu umawononga mafuta omwe ali ndi phosphorous. Phospholipase ndiyofunikira kwa thupi, chifukwa phosphorous, yomwe imachokera ku chakudya, imasandulika kukhala ATP - molekyu yomwe imasunga mphamvu mwa iyo yokha ndikupereka kwa maselo ena. Phospholipase inagawika m'mitundu ingapo (A1, A2, B, C, D), koma okhawo omwe amadziwa sayansi ya chemistry ndiomwe amvetsetse kusiyana pakati pawo.

Tsiku lisanafike kusanthula, simungadye zakudya zamafuta, chifukwa izi zimapotoza zotsatira.

Kodi zolakwika mu phunziroli ndizotheka?

Zosatheka, koma zotheka.

Kudya zakudya zamafuta musanayesedwe.Ngati mumadya kanthu kena kokhala ndi mafuta, ndiye kuti lipase yomwe ili m'magazi imathamangira kumafuta omwe akubwera ndikuyamba kuwaphwanya, zomwe zimachepetsa kudandaula kwake.
Zovuta za mafupa a tubular. Mu ma fractures, ma enzyme omwe ali m'mafupa awa amatulutsidwa kulowa m'magazi, omwe amachititsa kuthamanga kwambiri.

Kuchuluka kwamakhalidwe

Lipase imachulukitsa pamene lita imodzi yamagazi ikapezeka zopitilira 190 . M'milandu yambiri, izi zimachitika pa chimodzi mwazifukwa ziwiri: kapamba amatulutsa lipase yambiri kuposa momwe amafunikira, kapena thupi siligwiritsa ntchito moyenera.

pachimake kapena pancreatitis yayikulu
chotupa chowopsa kapena chotupa mu kapamba,
matumbo,
peritonitis
mafupa
kulephera kwa aimpso
kunenepa kwambiri, matenda ashuga
phwando la barbiturates.

Yekhayo, kuchuluka sikukhudza thanzi la wodwalayo, koma zomwe zimayambitsa zimamveka bwino (ndizovuta kuti zindikire kutsekeka kapena kukhumudwa).

Kuti mubweretse kuchuluka kwa lipase kukhala yabwinobwino, muyenera kuchotsa zomwe zimayambitsa kukula kwake. Izi zikuyenera kuchitika mwachangu, chifukwa zonse zomwe zimapangitsa (kupatula kunenepa kwambiri, kuvulala kwa minofu yofewa komanso chifuwa chachikulu) zimawopseza thanzi ndi moyo wa wodwala pano ndi pano. Njira zochizira zimadalira matenda enieni, adokotala ayenera kusankha njira yochizira.

Kuti chimbudzi chikhale ndi chakudya chomwe chatha, pamafunika ma enzyme ambiri. Ndi ma protein awa omwe amakupatsani mwayi kuti muwononge mapuloteni ovuta, mafuta ndi chakudya chamafuta muzinthu zosavuta zomwe zingathe kubwezeretsanso luntha lanu.

Kodi lipase ndi chiyani?

Kapangidwe kazinthu kameneka ndi gawo logwira ntchito la enzyme. Lipase imatha kuphwanya zinthu zovuta m'mafuta kukhala triglycerides, kenako ndikupanga mafuta acids, omwe pamapeto pake amapita kuti atsimikizire metabolism.

Kuphatikiza pakupanga mphamvu, lipase imaphatikizidwanso pakuphatikizidwa kwamafuta a polyunsaturated mafuta acids ndi mavitamini osungunuka a mafuta A, D, E, F, K.

Katemera wa enzyme

Lipase ndi enzyme yomwe imasungidwa mu ziwalo zambiri, koma mosiyanasiyana.

Gwero lalikulu la enzyme ndi kapamba. Kuphatikiza pa chipangizochi, makina otsatirawa amathanso kubisirana pakamwa:

Malangizo a hepatocytes,
maselo am'mimba
matumbo am'mimba,
minofu yam'mapapo
maselo oyera - magazi oyera,
m`kamwa mwa mwana yoyamwitsa.

Mfundo za lipase

Udindo waukulu pakugawika kwamafuta ovuta kukhala zinthu zosavuta zimaperekedwa ndi pancreatic lipase. Kukhazikitsa kwake kumafunikira kutsatira kwake. Ndi lipancreatic lipase yomwe ndi kachigawo kakulidwe ka magazi komwe magazi amayesedwa.

Enzime imalowa m'matumbo amtundu ngati gawo lofooka la prolipase. Pambuyo podziwikirana ndi bile acids ndi co-lipase (enzyme ina yomwe imapangidwa ndi kapamba), prolipase imasandulika mawonekedwe ofunikira ndikuyamba kukwaniritsa ntchito yake. Amayamba kuphwanya mafuta omwe adakhudzidwa kale ndi mankhwala a bile acid.

Kuphatikiza pa chinthu chachikulu, pali gawo lachiwiri la enzyme, zigawo zomwe zimapangidwa ndi ziwalo zina.

Lingual lipase, yomwe imapangidwa ndi tiziwalo tating'ono ta tiubwino tatsopano, imapereka chiyambi cha kugaya chakudya ndi kuwonongeka kwamafuta mumkaka wa m'mawere omwe ali mkatikati mwa kamwa. Izi zitha kufotokozedwa ndikuti pancreatic enzymatic ntchito mchaka choyamba cha moyo sichinapangidwe bwino ndipo sizimalola kuyamwa mokwanira zinthu zofunika kuti zitsimikizire bwino.

Hepatic lipase imayang'anira kuwongolera kwa ma lipids a plasma. Amayang'anira kudya ndi kusamala kwa otsika osalimba lipoprotein ndi ma chylomicrons. Chosangalatsa ndichakuti, zomwe zili pamwamba pazinthu izi zimathandizira kuti pakhale zotupa zamatumbo a atherosulinotic. Ndiko kuti, mosadziwika, mulingo wabwinobwino wa hepatic lipase imagwira ntchito ngati choletsa kukula kwa atherothrombosis.
Mitsempha yamkati pambuyo poti yaphatikizidwe ndi mayendedwe am'mimba ndi gawo lachigono limatsimikizira kusweka ndi kuyamwa kwa mavitamini osungunuka a mafuta.

Chifukwa chiyani amatenga magazi a lipase?

Pakuwunika kwamwazi wamagazi, zomwe zimapezeka m'magawo ochepa pancreatic zitha kufotokozedwa, popeza zina zonsezo sizingafanizidwe chifukwa cha kuchuluka kochepa kopitilira magazi.

Chifukwa chake, chomwe chimapangitsa kuti pakhale sampling ya magazi nthawi zambiri chimakhala chizindikiritso cha matenda a kapamba - nthawi zambiri, chifuwa chachikulu. Nthawi zina amachita njira zingapo nthawi zosiyanasiyana kuti adziwe mphamvu za njirayi ndi luso la chithandizo chamankhwala.

Kukonzekera kwa Kusanthula

Kuyesedwa kwa magazi kwa lipase nthawi zonse kumayikidwa m'mawa, pamimba yopanda kanthu. Kuti mudziwe kuchuluka kwa lipase, pamafunika magazi a venous.

Musanapange kafukufuku kuti mufufuze lipase, muyenera kukonzekera.

Tsiku lisanafike mpanda, osapatula mafuta, zonunkhira, okazinga zakudya.
Kwa maola 8-12, siyani kudya chakudya chilichonse, mumatha kumwa tiyi ndi madzi osafooka okha.
Sizoletsedwa kumwa mowa usiku watatsala masiku atatu kuti ayesedwe.
M'tsiku lomaliza kuti muchepetse zolimbitsa thupi.

Ndi diagnostics ovuta, werengani musanayambe kugwiritsa ntchito njira zofufuzira zama radiology (fluorography, x-ray ya m'mimba, ndi zina).

Kulephera kutsatira malamulowo kumatha kupangitsa kuti munthu amasuke kwambiri poyankha zakudya zamafuta kapena zochita zolimbitsa thupi, kapena amathandizire kulepheretsa kugwira ntchito kwa pancreatic (atatha kuyatsidwa ndi radiation). Kuphwanya kotereku kumayambitsa zotsatira zolakwika, zomwe zingaphwanye kuzindikira komanso kusankha kwa zovuta mankhwala.

Pakadali pano, lipase yamagazi imatsimikiziridwa ndi njira ziwiri:

Zotsirizirazi nthawi zambiri zimagwiritsidwa ntchito mu labotore, chifukwa zimakhala ndi mphamvu kwambiri komanso kuthamanga.

Lipase yachilendo yamagazi

Kupatuka kwa magwiridwe antchito a chiwalo kumatha kukhazikitsidwa pamaziko a kuchuluka kapena kuchepa kwa lipase. Chifukwa cha izi tiyenera kudziwa zofunikira za mulingo wa enzyme m'thupi la munthu.

Mwa akazi ndi abambo, enzymatic ntchito ya lipase ili mu zofanana. Chowoneka mosiyanitsa pazambiri zake ndi zaka.

Kwa ana kuyambira nthawi yobadwa mpaka zaka 17, njira yodziwika bwino ya lipase m'magazi imaganiziridwa ngati ili m'magawo a 0 - 130 magawo 1 ml.

Akuluakulu azaka za 18 zakubadwa, kuchuluka kwa ma enzyme kupita ku 190 U / ml kumadziwika kuti ndikwabwino.

Chofunika ndikuwona mphamvu za zizindikiro, popeza mtundu wa lipase ndizambiri, koma umunthu payekha. Mtengo wapakati wazomwe zimakhala ndi enzyme ndi manambala 13 - 60 Units.

Ntchito Zowonjezera

Kuwonjezeka kwa lipase kumawonedwa ndikukula kwa njira zowopsa zomwe zimakhudzana ndi kuwonongeka kwa ziwalo zam'mimba thirakiti, nthawi zambiri za kapamba.

Kuchulukitsa kwa lipase kumatha kuonedwa ndikupanga zochitika zotsatirazi zamatenda:

pachimake kupweteka kwa kapamba ndi chitukuko chachikulu kapena kuchuluka kwa nthawi yayitali,
mumps pa 3 milungu matenda (nthawi yakugonjetsedwa kwa maselo a pancreatic ndi wothandizila wopatsirana),
chitukuko cha pancreatic necrosis,
Kukula kapena kupweteka kwa kapamba,
mafuta opaka m'mimba kapena zilonda zam'mimba,
matumbo necrosis,
pachimake aimpso kulephera
Biliary colic
cholestasis ndi chitukuko cha subhepatic jaundice,
peritonitis
matenda a metabolic (shuga, gout),
2-3 madigiri a kunenepa kwambiri.

Kuphatikiza pa kukhazikika kwa zikhalidwe za pathological, kuchuluka kwa enzyme komwe kumachitika chifukwa cha kumwa mankhwala okhala ndi mbali iyi. Mwachitsanzo, kugwiritsidwa ntchito kwa nthawi yayitali kwa indomethacin, heparins mwachindunji, barbiturates ndi analgesics. Ndiye kuti, kuti muchepetse kuchuluka kwa lipase m'magazi, ndikokwanira kungoimitsa kumwa kwa mankhwala omwe ali pamwambapa.

Komanso, zomwe adawonetsa zidawonetsa kuti milingo ya magazi ya lipase imachuluka ndi ma fractures a mafupa akulu a tubular. Izi ndichifukwa choti mafupa akulu akulu amasamba okhala ndi mafuta ambiri, omwe, pamene kukhulupirika kwa ziwiya kumaphwanyidwa, amalowa m'magazi. Mosangalatsa, thupi limayamba kuwonjezera kutulutsa kwa lipase kuti muchepetse kuchuluka kwa mafuta. Vutoli limathanso kuyambitsa embolism yamafuta.

Mu chilonda chachikulu cha pancreatitis ndi zina zomwe zimapangitsa kuti enzyme iwonjezeke, kuchuluka kwake m'magazi sikuwonjezereka nthawi yomweyo. M'masiku oyambirawa, ndizosavuta kupeza matenda pogwiritsa ntchito njira yofufuzira iyi. Lipase limakhala ndi phindu lalikulu pambuyo masiku atatu odwala. Mulingo wambiri wa enzyme, ngakhale mankhwalawo atasankhidwa bwino, amatha masiku 10-14. Kenako imayamba kuchepa.

Milingo yotsika kwambiri

Mlingo wotsika kwambiri wa lipase samawerengedwa kuti sachokera ku ziwerengero zomwe zili munthawi ya enzyme m'magazi, koma kuchokera pazofunikira za pancreatic lipase, zomwe m'munsi mwake mumakhala 13 U / ml. Zomwe zimapangitsa kuchepa kwa ntchito ya enzyme imaphatikizapo chikhalidwe chobadwa nacho, kusintha kwa matendawa, kapena mavuto a anamentary.

Kukula kwa khansa, kuphatikiza pakuwonongeka kwa chinthu chobisalira chokha (ndi khansa ya kapamba, enzyme imadzuka), imayambitsa kuchepa kwa ntchito ya lipase.
Lipase imachepetsedwa ndi chakudya chosayenera, pomwe gawo lotsiriza limapezeka pazowonjezera pakati pa mapuloteni, chakudya ndi mafuta, zomwe zimapangitsa kufooka kwa enzyme m'magazi. Izi zimabweretsa kutsika kwa kuchuluka kwa lipase.
Chizindikiro chovuta chimawerengedwa ngati gawo lochepa la enzyme mu pancreatitis yovuta kwambiri. Izi zikutanthauza kuti matendawo ayamba kudwala.
Matenda a m'magazi amachititsa kuti pakhale zotere chifukwa cha kuchuluka kwa lipids.

PITIRIZANI NTCHITO YOLALIKIRA YOPHUNZITSIRA 1. Muikeni wodwalayo pabedi, tebulo logwiritsira ntchito 2. Valani magolovesi osalala. 3. Tengani ma tweezers ndi swab wothira mafuta enamel kapena ammonia, yeretsani khungu kuzungulira bala. 4. Su

Kutulutsa mano, magazi amatha kupita theka la ola kapena ola, ndipo izi ndizabwinobwino. Kenako zovalazo zizipangika pamalo owonongeka, ngati kumangirira bala. Ndi zochotsa zovuta, zimatha kutulutsa magazi mpaka tsiku, koma zimachitika kuti nthawi imeneyi yayamba

Ngati dzino lipweteka pansi pa korona, zifukwa zingakhale zosiyana kwambiri - kuchokera pakukonzekera kosayenera pamaso pa ma prosthetics mpaka kukalowa kwa thupi lachilendo kulowa mu ngalande. Nthawi zambiri, ndizotheka kudziwa vuto pokhapokha kwakanthawi mutapanga ndi