Aspikor - (Aspikor) malangizo ogwiritsira ntchito

Mankhwala osokoneza bongo amalepheretsa enzyme ntchito cycloo oxygenase 1 ndi 2 (khazikitsani kapangidwe ka prostaglandins).

Mankhwala Aspicor ali ndi ma analgesic (analgesia), odana ndi kutupa komanso antipyretic zotsatira.

The yogwira mankhwala acetylsalicylic acid amachepetsa mapangidwe a prostaglandins, motsogozedwa ndi omwe hyperalgesia ndi kudzikuza. Kuchepa kwa ma prostaglandins pakatikatimachikalac (makamaka E1) imayambitsa thukuta lochulukirapo, kukulira kwa lumen kwa mitsempha ya magazi pakhungu, chifukwa, kutsika kwa kutentha kwa thupi.

An analgesic zotsatira zimatheka ndi zotumphukira komanso pakati zochita za mankhwala. Aspicore akuletsa kaphatikizidwe thromboxane A2 m'mitsempha yamagazi m'magazi, amachepetsa thrombosiskuphatikiza kwa mapulateleti ndi kuphatikiza.

Odwala omwe ali ndi vuto losakhazikika la angina, mankhwala omwe amagwira acetylsalicylic acid amatha kuchepetsa kufa, chiopsezo cha kulowerera kwam'mnyewa wamtima.

Mphamvu ya antiplatelet imatha pafupifupi sabata itatha kumwa kamodzi.

Mlingo wa tsiku ndi tsiku wa magalamu 6 kapena kupitilirapo umawonjezera prothrombin nthawi, umalepheretsa kaphatikizidwe prothrombin m'matumbo a chiwindi.

Mankhwalawa Aspicore amawonjezera pafupipafupi zovuta za hemorrhagic panthawi yochitidwa opaleshoni.

Mothandizidwa ndi mankhwalawa, chimbudzi chimakulitsidwa uric acid (chifukwa chophwanya tubular reabsorption mu impso).

Zizindikiro zogwiritsidwa ntchito

Aspicor amalembera mpumulo ululu (mitundu yofatsa komanso yofikira) ya magwero osiyanasiyana: migraine, mutu, myalgiaradicular syndrome khalidiarthralgia lumbago, neuralgia, mano.

Mankhwalawa amagwiritsidwa ntchito ngati matenda opweteketsa thupi pochotsa matenda opatsirana, otupa.

Contraindication

Mapiritsi a Aspicor sanalembedwepo hemorrhagic diathesis, ndi mawonekedwe amtundu umodzi wa acetylsalicylic acid, ndi mphumu ya bronchial, magazi amatuluka m'mimba, ndi zilonda zam'mimba zam'mimba, kuphatikiza kwa methotrexates, kupaka pakati, zaka zapakati pa khumi ndi zisanu.

Zotsatira zoyipa

Mapiritsi a Aspicor angayambitse matenda am'mimba, nseru, mayankho amtundu wa angioedema, zotupa pakhungu bronchospasm.

Potengera maziko a chithandizo, zosokoneza mu impso ndi chiwindi Matenda a Reye (kupangika mwachangu kwa kulephera kwa chiwindi, chiwindi dystrophy ndi encephalopathy), leukopenia, thrombocytopeniakuchepa magazi kwambiri.

Kutenga nthawi yayitali kumatha kutsatiridwa ndi chisangalalozotupa ndi zotupa zam'mimba zotupa, chizungulire, migraine, kusanza, kusokonezeka kowoneka,yade interstitialmagazi, papillary necrosis, prerenal azotemia ndi hypercalcemia ndi hypercreatininemia, kutupa, kuchuluka kwa matenda a mtima, aseptic meningitis, kuchuluka kwa michere ya chiwindi, nephrotic syndrome.

Aspicor, malangizo ogwiritsira ntchito (Njira ndi Mlingo)

Mapiritsi a Aspicore amatengedwa pakamwa.

Ndi ululu, febrile syndrome Mankhwalawa amatengedwa pakamwa mpaka magalamu atatu (mlingo woyenera ndi 0,5-1 magalamu patsiku) pa 3 Mlingo.

Monga analgesic komanso anti-kutupa othandizira, Aspicor ndi mankhwala 325 mg.

Kutalika kwa mankhwalawa sikuyenera kupitirira milungu iwiri.

Mawonekedwe a efflementscent a mankhwalawa ayenera kuyamba kusungunuka mu 100-200 ml ya madzi. Mlingo umodzi wa mankhwalawa ndi 0,25-1 magalamu (katatu patsiku).

Bongo

Woopsa milandu bongo, hypoglycemia, hyperventilation, chikomokere, malungo, ketoacidosis, mtima ndi kupuma kulephera.

Kufunika kuchipatala mwadzidzidzi, kugwiritsa ntchito makala ophatikizika, phala lam'mimba, diuresis, hemodialysis, ndi chizindikiro cha chithandizo chikufunika.

Kuchita

Malangizo ogwiritsira ntchito Aspicore salimbikitsa kugwiritsa ntchito mankhwalawa nthawi imodzi ndi othandizira a hypoglycemic. valproic acid, methotrexate, antiplatelet agents, thrombolytics,anticoagulants, heparin, sulfonamides, antihypertensive ndi uricosuric othandizira, okodzetsa.

Kuopsa kwa magazi m'mimba kumawonjezeka ndimankhwala amodzimodzi omwe amapezeka ndi glucocorticosteroids ndi mankhwala okhala ndi ethanol.

Aspikor imatha kuwonjezera kuchuluka kwa barbiturates, digoxin, mchere wa lithiamu mu plasma.

Mafuta a acetylsalicylic acid amachepetsedwa panthawi ya chithandizo maantacid.

Mphamvu ya hematotoxic ya Aspicore imawonjezeka ndi mankhwala a myelotoxic mankhwala.

Malangizo apadera

Kugwiritsidwa ntchito kwa Aspikor ngati mankhwala othana ndi kutupa kumachepa chifukwa cha chiwopsezo chachikulu chotenga NSAIDs-gastropathy.

Kutalika kwa mankhwalawa sikuyenera kupitirira masiku 5.

Pakadali pano, mankhwalawa saikidwa rheumatic choreaMatupi awo sagwirizana ndi mawonekedwe myocarditis, ndi nyamakazi, komanso pericarditis ndi rheumatism.

Aspicor tikulimbikitsidwa kuti aletsedwe masiku 5-7 ntchito isanachitike.

Kutenga nthawi yayitali kumafunikira kuwunika ma magazi, kuwunika ndowe za magazi amizimu.

Mankhwalawa amatha kupatsa zotsatira za teratogenic.

Acetylsalicylic acid amachotseredwa mkaka wa m'mawere.

Mankhwala angayambitse matenda oopsa a gout.

Tulutsani mawonekedwe, ma CD ndi mapangidwe Aspicor ®

Mapiritsi okhala ndi kanthu okhala oyera kapena oyera, pafupi, biconvex, pamtanda - gulu lalikulu la mitundu yoyera kapena yoyera.

Othandizira: microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, colloidal silicon dioxide (aerosil), stearic acid.

Kuphatikizika kwa kuphatikizika kwa enteric: methaconic acid-ethyl acrylate Copolymer, propipylene glycol, macrogol 4000, titanium dioxide, talc.

Ma PC 10 - matumba otumphuka (1) - mapaketi a makatoni.
Ma PC 10 - mapepala otumphukira (2) - mapaketi a makatoni.
Ma PC 10 - matumba otumphukira (3) - mapaketi a makatoni.
Ma PC 10 - matumba a matuza (6) - mapaketi a makatoni.
20 ma PC. - matumba otumphuka (1) - mapaketi a makatoni.

Zotsatira za pharmacological

NSAIDs, wothandizira antiplatelet. Makina a zochita za acetylsalicylic acid amachokera pa choletsa chosasintha cha cycloo oxygenase-1 (COX-1), chifukwa chomwe pali kutsekedwa kwa kapangidwe ka thromboxane A 2 komanso kuponderezana kwa kuphatikiza kwa mapulateleti. Amakhulupirira kuti acetylsalicylic acid ali ndi njira zina zothandizira kuponderesa kuphatikizana kwa maselo othandiza magazi kuundana, omwe amakulitsa kukula kwake m'magulu osiyanasiyana a mtima.

Acetylsalicylic acid ilinso ndi anti-yotupa, analgesic, antipyretic kwenikweni.

Pharmacokinetics

Pambuyo pakukonzekera kwamlomo, acetylsalicylic acid imatengedwa kuchokera kumtumbo yaying'ono. C max mu plasma amawonedwa pafupifupi maola atatu atatha kumwa mankhwalawa.

Acetylsalicylic acid amakhala ndi gawo la metabolism m'chiwindi ndikupanga ma metabolites osagwira.

Imafufutidwa ndi impso, zonse zosasinthika ndi metabolites. T 1/2 acetylsalicylic acid ndi pafupifupi mphindi 15, chifukwa cha metabolites - pafupifupi maola atatu

Zisonyezero Aspikor ®

• kupewa kupewa pachimake myocardial infaration pamaso pa zinthu zoopsa (mwachitsanzo, matenda ashuga, hyperlipidemia, ochepa matenda oopsa, kunenepa kwambiri, kusuta, kukalamba),
• kupewa kubwereza myocardial infaration,
• angina wosakhazikika,
• kupewa matenda opha ziwalo (kuphatikizapo odwala omwe ali ndi matenda osakhalitsa a cerebrovascular matenda),
• kupewa ngozi yochepa yam'mimba,
• kupewa thromboembolism atachitidwa opaleshoni ndi zina zowonjezera zamitsempha (mwachitsanzo, zamitsempha yama cell a m'mitsempha, kukokoloka kwa mitsempha, carotid artery endarterectomy, arteriovenous shunting, carotid artery angioplasty),
• kupewa kwamitsempha yama mtima ndi thromboembolism yam'mitsempha ya m'mimba ndi nthambi zake (mwachitsanzo, ndi kusakhazikika kwa nthawi yayitali chifukwa cha kulowererapo kwakukulu kwa opaleshoni).

Mlingo

Mapiritsi ayenera kumwedwa pakamwa, asanadye, ndi madzi ambiri.

Kupewa kwa kulowetsedwa kwamphamvu kwambiri kwa m'mnyewa wamatumbo: 100-200 mg / tsiku (piritsi loyamba liyenera kutafunidwa kuti lizichotse mwachangu).

Kupewera kwa pachimake khunyu yokhala pachimake kupsinjika pamaso pazochitika: 100 mg / tsiku.

Kupewa kwa kubwerezanso kwa myocardial infaration, angina osakhazikika, kupewa kugunda kwa mtima komanso kuchepa kwa vuto la kuchepa kwa magazi, kupewa masoka a thromboembolic pambuyo pa opaleshoni kapena maphunziro owonjezera: 100-300 mg / tsiku.

Kupewera kwa minyewa yayikulu ya thrinosis ndi thromboembolism yam'mitsempha yamagazi ndi nthambi zake: 100-200 mg / tsiku.

Mankhwalawa adapangira kuti azigwiritsidwa ntchito kwa nthawi yayitali. Kutalika kwa mankhwala kumatsimikiziridwa ndi adokotala.

Zotsatira zoyipa

Kuchokera pamimba: kukhumudwa, kutentha pa mtima, kusanza, kupweteka pamimba, zotupa zam'mimba zam'mimba ndi duodenum (kuphatikizapo mafuta opaka), kutulutsa magazi m'mimba, kuchuluka kwa michere ya chiwindi.

Kuchokera pakupuma dongosolo: bronchospasm.

Kuchokera ku hemopoietic dongosolo: kuchuluka magazi, osowa - kuchepa kwa magazi.

Kuchokera kumbali ya chapakati mantha dongosolo: chizungulire, tinnitus.

Zotsatira zamagetsi: urticaria, edema ya Quincke, anaphylactic reaction.

Mimba komanso kuyamwa

Kugwiritsa ntchito salicylates mu Mlingo woyambirira m'nthawi yoyambirira ya mimba kumalumikizidwa ndi kuchuluka kwa zolakwika za fetal (kupatuka kwapakati, zolakwika za mtima). Mu trimester yachiwiri yokhudzana ndi kubereka, ma salicylates amatha kuyikidwa pokhapokha ngati akuwonetsetsa kuti ali pachiwopsezo komanso kupindula.

Mu wachitatu trimester wa mimba, salicylates mu Mlingo wambiri (oposa 300 mg / tsiku) amalepheretsa ntchito, kutsekeka msanga kwa ductus arteriosus mu mwana wosabadwayo, kuchuluka kwa magazi kwa mayi ndi mwana wosabadwayo, ndipo makonzedwe atangobadwa kumene angayambitse kukha magazi kwakanthawi, makamaka ana akhanda. Kukhazikitsidwa kwa salicylates mu III trimester ya mimba kumatsutsana.

Ma salicylates ndi ma metabolites ang'onoang'ono amawonjezedwa mkaka wa m'mawere. Mwadzidzidzi kudya kwa salicylates pa mkaka wa m`mawere sikuyenda limodzi ndi zovuta mu mwana ndipo sikutanthauza kuti kuyamwa yoyamwitsa. Komabe, ngati mukufuna kugwiritsa ntchito mankhwalawa kwa nthawi yayitali kapena kupatsidwa mlingo waukulu, kuyamwitsa kuyenera kuyimitsidwa nthawi yomweyo.

Kuyanjana kwa mankhwala osokoneza bongo

Ndi munthawi yomweyo kugwiritsa ntchito acetylsalicylic acid timapitiriza izi:

• methotrexate pochepetsa impso ndikuyichotsa pakulankhulana ndi mapuloteni,
• heparin ndi anticoagulants osalunjika chifukwa cha vuto la kupatsidwa zinthu za m'magazi ndi kusamutsa anticoagulants osadziwika polumikizana ndi mapuloteni,
• thrombolytic ndi antiplatelet mankhwala (ticlopidine),
• digoxin chifukwa kuchepa kwa impso yake,
• hypoglycemic wothandizila (insulin ndi sulfonylurea zotumphukira) chifukwa cha hypoglycemic katundu wa acetylsalicylic acid palokha muyezo waukulu ndi kuchoka kwa sulfonylurea zotumphukira polumikizana ndi mapuloteni,
• valproic acid chifukwa chakuchoka kwawo kulumikizana ndi mapuloteni.

Mphamvu yowonjezera imawonedwa mukutenga acetylsalicylic acid ndi Mowa.

Acetylsalicylic acid imafooketsa uricosuric mankhwala (benzbromarone) chifukwa cha mpikisano wa tubular kuchotsa kwa uric acid.

Mwa kukulitsa kuchotsa kwa ma salicylates, systemic corticosteroids imafooketsa mphamvu yawo.

VERTEX AO (Russia)