Mankhwala amapezeka mu mawonekedwe a kulowetsedwa. Ndiwowoneka bwino ngati madzi komanso wachikasu.

Kukhazikika kumogulitsidwa, komwe kumagwiritsidwa ntchito kukonza yankho. Ndi yankho lomveka bwino kapena labwino kwambiri.

Mapiritsi a Ciprinol 250 mg ndi biconvex, ali ndi mawonekedwe ozungulira, oyera mtima, okhala m'mphepete. Amakutidwa ndi nembanemba wa filimu, mbali imodzi ya piritsi pali notch.

Mapiritsi a Ciprinol 500 mg ndi biconvex, ali ndi mawonekedwe owulungika, oyera. Phaleli limakutidwa ndi nembanemba wa filimu, mbali imodzi pali notch.

Mapiritsi a Ciprinol 750 mg ali ndi chowulungika, amakhala ndi zokutira zoyera za filimu, ndipo pamakhala matcheni mbali zonse ziwiri za piritsi.

Zotsatira za pharmacological

Ciprinol (ciprofloxacin) imakhala ndi antibacterial thupi. Ichi ndi m'badwo wachiwiri monofluorinated fluoroquinolone. Mothandizidwa ndi, topoisomerase II, puloteni yomwe imatsimikizira kubwereza ndi biosynthesis ya bacteria deoxyribonucleic acid, imalepheretseka. Amatenganso mbali yogawa ma cell mabacteria komanso michere yama protein.

Ciprinol imakhala ndi bactericidal, imathandiza kwambiri polimbana ndi mabakiteriya opanda gramu. Chifukwa chake, mankhwalawa amagwiritsidwa ntchito pochiza matenda oyambitsidwa ndi mabakiteriya.

Komanso, mabakiteriya angapo abwino amathandizika ndi Ciprinol: Staphylococcus spp., Streptococcus spp. Zimakhudza tizilombo tambiri ta intracellular.

Kugwiritsa ntchito kwambiri kwa mankhwalawa kumadziwika pochiza matenda opatsirana omwe amakwiya ndi Pseudomonas aeruginosa. Ciprinol imagwira ntchito motsutsana ndi chlamydia, anaerobes, mycoplasmas. Bowa, ma virus, protozoa makamaka amawonetsa kukana machitidwe a mankhwala.

Pharmacodynamics ndi pharmacokinetics

Ciprinol mwanjira ya mapiritsi amatengeka mwachangu, kulowa m'mimba. Mayamwidwe ake samakhudzidwa ndi kudya chakudya, kukhudzana kwa moyo wawo sikuchepetsedwa. Bioavailability ndi 50-85%. Kuchuluka kwazinthu zofunikira m'magazi a wodwala kumawonedwa pafupifupi maola 1-1,5 mutatha kumwa mapiritsi. Pambuyo mayamwidwe, chinthu yogwira chimagawidwa mu minofu ya genitourinary ndi kupuma thirakiti, mu magazi, zotumphukira, khungu, mafuta, zimakhala, malovu, sputum, madzimadzi. Imalowetsanso ma cell (macrophages, neutrophils), omwe amawona magwiridwe ntchito ake mankhwalawa matenda opatsirana omwe tizilomboti timayatsidwa patokha.

Zotsatira za biotransformation zomwe zimachitika m'chiwindi, metabolites yogwira ntchito amawoneka. Mankhwalawa amachotsedwa m'thupi kudzera mu impso, komanso machitidwe owonjezera (ndi ndowe, ndi ndulu). Hafu ya moyo wa mankhwala kuchokera mthupi amachokera ku maola 5 mpaka 9. Chifukwa chake, pakuthandizira mankhwala, ndikokwanira kumwa mankhwalawa kawiri patsiku.

Pambuyo kulowetsedwa kwa mtsempha wa mtsempha wa ciprinol, pazotheka kuti anthu ambiri azigwirizana pambuyo pa ola limodzi. Ndi kukhazikitsidwa kwa mtsempha wa magazi m'thupi lathu, zomwe zimapangitsa kuti pakhale kuchuluka kwazinthu zambiri poyerekeza ndi madzi a m'magazi, zimadziwika. Ciprofloxacin imalowa mkati mwa placenta.

Mwa anthu omwe ali ndi vuto lofanana ndi aimpso, theka la moyo wa mankhwalawa limachokera ku maola atatu mpaka asanu. Odwala omwe ali ndi vuto la aimpso, kuwonongedwa kwa theka kumawonjezereka mpaka maola 12.

Pambuyo kulowetsedwa, mankhwalawa amathandizidwa kudzera mu impso. Pafupifupi 50-70% ya mankhwalawa amachotsedwa osasinthika, 10% ina imachotsedwa mu mawonekedwe a metabolites, ndalama zotsalira - kudzera m'mimba. Ndi mkaka wa m'mawere, owerengeka omwe amagwira ntchito amachotsedwa.

Zisonyezero Ziprinol

Ciprinol imayikidwa pakakhala zofunika kuchiza matenda omwe adatsitsidwa ndi ma microorganic omwe ali ndi chidwi chachikulu cha ciprofloxacin, pomwe munthu amatenga matenda ena. Chifukwa chake, zomwe zikuwonetsa kugwiritsa ntchito mankhwalawa ndi izi:

matenda opatsirana thirakiti:bronchitischibayo, cystic fibrosis, bronchiectasis, etc.,
matenda opatsirana a ENT: otitis media, mastoiditis, sinusitis,
kwamikodzo thirakiti ndi matenda a impso: cystitis, matenda amitsemphapyelonephritis,
matenda opatsirana a kumaliseche, komanso ziwalo zina za m'chiuno: prostatitis, epididymitis, endometritis, chlamydia, salpingitis, etc.,
matenda opatsirana a m'mimba: cholecystitischolangitis, chinyezi cholowerera, kutsekula m'mimba, kukulira chifukwa cha matenda, etc.
matenda a pakhungu ndi minofu yofewazilonda zam'mimba, zilonda zam'mimba, mabala, zilonda,
matenda a musculoskeletal: nyamakazi ya septic, osteomyelitis,
chitukuko cha sepsis, matenda mwa anthu omwe ali ndi vuto lolephera chitetezo chokwanira,
njira zodzitetezera kuti musadwale matenda pakachitika opaleshoni ndi mafupa,
mankhwala ndi kupewa pulmonary anthrax.

Contraindication

Ciprinol sayenera kufotokozedwera matenda ndi zinthu zotsatirazi:

kuchuluka kwamphamvu kwa ciprofloxacin, mankhwala ena omwe ali m'gulu la fluoroquinolones kapena zigawo zina zamankhwala.
mimba ndi nthawi yodyetsa,
zaka mpaka 18 (kupatulapo chithandizo chamankhwala omwe amayamba chifukwa cha Pseudomonas aeruginosa mwa ana azaka 5 mpaka 17 omwe ali ndi vuto la pulmonary cystic fibrosis, amagwiritsidwanso ntchito pochiza ndi kupewa anthrax mwa ana),
osagwiritsa ntchito mankhwalawa nthawi yomweyo Tizanidine.

Ciprinol amatchulidwa mosamala kwa odwala kwambiri atherosulinosis mitsempha yaubongo, magazi osokonekera amayenda mu ubongo, komanso anthu akuvutika khunyu, matenda amisala, kulephera kwa impso kapena chiwindi. Mkhalidwe wa okalamba omwe amathandizidwa ndi mankhwalawa, komanso omwe ali ndi vuto la glucose-6-phosphate dehydrogenase, ayenera kuyang'aniridwa bwino.

Zotsatira zoyipa

Matumbo oyenda: zovuta zovuta kuzimvetsa, kukomoka, hepatonecrosis, hepatitis, cholestatic jaundice, pseudomembranous colitis.
Mitsempha yamkati yotupa:mutu, migraine, kuchuluka kwa kutopa ndi nkhawa, kukomoka, kukokana, kugwedezeka, kuchuluka kwa ICP, kukhumudwa, kusokonezeka kwa chikumbumtima, kuyerekezera zinthu zina, malingaliro ena.
Zosangalatsa:kusawona bwino, kununkhiza, kumva, tinnitus.
Mtima wamtima: mavuto a mtima, tachycardia, kutsitsa magazi, kupopa kwakanthawi.
Hematopoietic dongosolo: anemia, leukopenia, thrombocytopenia, granulocytopenia, thrombocytosis, leukocytosis.
Njira yamikodzo: crystalluria, hematuria, glomerulonephritis, polyuria, dysuria, albinuria, magazi, nephritis, kuchepa kwa nayitrogeni wa impso.
Zizindikiro zoyipa: urticaria, kuyabwa kwa khungu, matuza komanso magazi, zotupa za m'magazi, kutentha kwa mankhwala, edema, vasculitis, erythema nodosum, exanthema, ndi zina zambiri.
Dongosolo laumiseche: nyamakazi, arthralgia, kupindika kwa tendon, tendovaginitis, myalgia, edema.
Mawonetsero ena: candidiasis, kuzindikira kuwala, thukuta, chikhalidwe chofooka.
Malinga ndi zizindikiro zasayansi: kuchuluka kwa hepatic transaminases ndi zamchere phosphatase, hypoprothrombinemia, hyperuricemia, hypercreatininemia, hyperbilirubinemia, hyperglycemia
Mukalowetsedwa, malingaliro am'deralo amatha kuonekera.

Malangizo ogwiritsira ntchito Ciprinol (njira ndi Mlingo)

Mitsempha yonse iwiri yophatikizira yankho la Ciprinol ndi Ciprinol 500 mg (pamapiritsi) imayikidwa kawiri pa tsiku. Mitundu yofatsa yamatenda amkodzo kapena kupuma, komanso kutsegula m'mimba Mlingo umodzi wa mankhwala ndi 250 mg. Woopsa m'matenda kapena ndi zovuta zovuta, wodwala ayenera kumwa 500 kapena 750 mg ya mankhwalawo.

Malangizo a Ciprinol 500 mg amafotokoza kuti ndi gonorrhea mankhwalawa amatengedwa kamodzi. Ngati mtsempha wa intravenous ukuchitika, kulowetsedwa pang'onopang'ono ndikofunikira, ndi mlingo wa 200-400 mg. Ngati wodwala wapezeka ndi pachimake chinzonono, 100 mg ya Ciprinol imaperekedwa kamodzi. Pofuna kupewa zovuta zokhudzana ndi matenda a postoperative, pafupifupi ola limodzi musanayambe opaleshoni, 200-500 mg ya Ciprinol amaperekedwa kwa wodwala.

Ngati wodwalayo aphwanya impso, ndiye kuti tsiku lililonse mankhwalawa akumwa pakumwa amachepetsedwa ndi theka.

Muyenera kumwa mapiritsi musanadye, ndikofunikira kumwa mankhwalawa ndi madzi ambiri.

Bongo

Ndi bongo wambiri, mawonetsedwe azizindikiro zingapo amatha kudziwika: chizunguliremutu, kusanza, nseru, m'mimba. Ngati kwambiri bongo, kusokonezeka chikumbumtima, kugwedezeka, kugwedezeka, kuwonetsa kuyerekezera zinthu zina zotheka.

Chithandizo cha Syndrome chimachitika, ndikofunikira kuonetsetsa kuti wodwalayo amalandira madzi okwanira, komanso kutsuka m'mimba. Zothandiza, kaboni yodziyimira imapangidwanso.

Kuchita

Ngati chithandizo chikuchitika nthawi yomweyo Ciprinol ndi Didanosine, ndiye kuti kuchepa kwa mayamwidwe a ciprofloxacin.

Mothandizidwa ndi ciprofloxacin, ndende imawonjezeka ndi theka la moyo wa theophylline ndi xanthines zina zambiri.

Ndi chithandizo chanthawi yomweyo ndi ciprofloxacin ndi othandizira pakamwa ndi hypoglycemic komanso ma anticoagulants, index ya prothrombin imachepa.

Mwina kukulitsa khunyu ndikutenga ciprofloxacin ndi NSAIDs.

Kuperewera kwa ciprofloxacin kumatha kuchepa limodzi ndi ma antiacid, mankhwala omwe amakhala ndi aluminium, chitsulo, zinc, ndi magnesium ion. Ndikofunikira kuonetsetsa kuti nthawi yomwe pakati pa kumwa mankhwalawa ndi yochepera maola 4.

Ngati ciprofloxacin ndi cyclosporin zimagwiritsidwa ntchito nthawi yomweyo, ndiye kuti nephrotoxic zotsatira zakumapeto zimalimbikitsidwa.

Metoclopramide imayendetsa mayamwidwe a ciprofloxacin. Zotsatira zake, nthawi yofika ndende yake yayikulu kwambiri ya plasma imachepa.

Mankhwala a ciprofloxacin ndi uricosuric mankhwala, mawonekedwe a ciprofloxacin amachepetsedwa ndipo ndende yake mu plasma imakulanso.

Ndi makonzedwe omwewo munthawi yomweyo ndi mankhwala ena omwe ali ndi antimicrobial effect, synergism imadziwika.

Malangizo apadera

Anthu omwe ali ndi vuto la kukomoka, khunyu, matenda am'mimba komanso matenda am'mimba, ciprofloxacin imatha kuikidwa pokhapokha ngati pali zizindikiro zofunika.

Ngati kutsegula m'mimba kwambiri kumachitika pakumwa, mawonekedwe akulu sayenera kuphatikizidwa.pseudomembranous colitis. Mukatsimikizira kuti mukudwala matendawa, ndikofunikira kusiya mankhwala mwachangu ndikuchiza wodwala.

Ngati kupweteka kwa tendon kumadziwika, komanso zizindikiro zoyambirira za tendovaginitis, njira yothandizira imayimitsidwa, chifukwa pakhala pali milandu ya kutupa kwa tendon komanso kupasuka panthawi yamankhwala omwe ali ndi fluoroquinolones.

Zochita zolimbitsa thupi kwambiri siziyenera kuchitidwa nthawi ya chiprofloxacin.

Mlingo wovomerezeka watsiku ndi tsiku suyenera kupitilira, chifukwa chiopsezo cha makristasi chimawonjezeka. Kuti mukhale ndi mkodzo mulingo woyenera, ndikofunikira kumwa madzi okwanira nthawi ya mankhwalawa.

Mukamalandira mankhwala, ma radiation yolimba a UV sayenera kuloledwa.

Kwa anthu omwe ali ndi vuto la shuga-6-phosphate dehydrogenase, hemolytic anemia imatha kuchitika ndi makonzedwe a Ciprinol.

Pochiza ndi maantibayotiki, munthu amayenera kuyendetsa bwino magalimoto ndikuchita zina zokhudzana ndi chidwi chowonjezeka.

Analogs omwe ali ndi vuto lofananalo ndi mankhwala osokoneza bongo Tsiprovin, Cyprrosan, Ciprolon, Cypropane, Cyproquin, Tarifayidi, Syflox, Perty, Reor, Oflomak, Norilet, Oflocide, Negaflox, Norfacin ndi ena onse. Ndikofunika kufunsa dokotala wanu kuti ndi mankhwala ati omwe muyenera kusankha, komanso ngati mankhwalawo ndi othana ndi mankhwala kapena ayi.

Ndi maantibayotiki

Kuphatikiza kwa ciprinol ndi ceftazidime ndi azlocillin pochiza matenda oyambitsidwa ndi Pseudomonas spp. mankhwalawa matenda a streptococcal, kuphatikiza kwa meslocillin, azlocillin, ndi mankhwala ena a beta-lactam amaloledwa. Pochiza matenda a staph, mankhwalawa amaphatikizidwa ndi vancomycin ndi isoxazolepenicillins. Pochiza matenda a anaerobic, kuphatikiza ndi metronidazole ndi clindamycin ndikuloledwa.

Ndi mowa

Sizoletsedwa kumwa zakumwa zoledzeretsa mukamalandira mankhwala ndi Ciprinol.

Mankhwala amatha kutumikiridwa pochiza ana ndi achinyamata osakwana zaka 18 pokhapokha ngati chithandizo ndi prophylaxis cha anthrax chikufunika, komanso mankhwalawa chifukwa cha Pseudomonas aeruginosa mu ana omwe ali ndi pulmonic cystic fibrosis.

Ciprofloxacin

Ciprofloxacin: malangizo ogwiritsira ntchito ndi kuwunika

Dzina lachi Latin: Ciprofloxacinum

Code ya ATX: S03AA07

Zogwira pophika: Ciprofloxacin (Ciprofloxacinum)

Wopanga: PJSC Farmak, PJSC Technolog, OJSC Kyivmedpreparat (Ukraine), LLC Ozon, OJSC Veropharm, OJSC Synthesis (Russia), C.O. Kampani ya Rompharm S.R.L. (Romania)

Kusintha malongosoledwe ndi chithunzi: 04/30/2018

Mitengo muma pharmacies: kuchokera ku ma ruble 6.

Ciprofloxacin ndi mankhwala antimicrobial omwe ali ndi chiwonetsero chambiri cha bactericidal kuchokera ku gulu la fluoroquinolones.

Ndemanga za Ciprinol

Kuunika kwa odwala kumawonetsa kuti mothandizidwa ndi Ciprinol adatha kuthana ndi matenda omwe adayambitsa matendawa. Komabe, pali ndemanga zambiri zakuwonetsa kuwonetsa pazovuta zake pamankhwala. Makamaka, dysbacteriosis, matenda a mafangasi, ndi kuwonongeka kwa ziwonetsero zamagazi a labotale zimatchulidwa. Dziwani kuti maantibayotiki ayenera kumwedwa panthawi yomwe adokotala adawauza.

Mlingo ndi makonzedwe

Mlingo watsimikiza ndi dokotala, kutengera kuopsa kwa matendawa, mtundu wa matenda, mkhalidwe wamthupi, zaka (zochepera 18 kapena kupitirira 60), kulemera ndi impso.

Zizindikiro zogwiritsidwa ntchito

Mlingo wosakwatiwa / tsiku lililonse wa akulu

Kutalika konse kwa chithandizo

(kuganizira mankhwala ndi parenteral mitundu ya ciprofloxacin)

Pansi kupuma thirakiti matenda

Matenda apamwamba kwambiri a m'mapapo

Kuchulukitsa kwa matenda a sinusitis

Matenda othandizira otitis

Malignant otitis externa

Matenda amitsempha

Amayi amiseche - kamodzi 500 mg

Cystitis yovuta, pyelonephritis yovuta

Osachepera masiku 10, nthawi zina (mwachitsanzo, ndi ma abscesses) - mpaka masiku 21

Milungu 2-4 (pachimake)

Masabata 4-6 (aakulu)

Matenda amtunduwu

Gonococcal urethritis ndi cervicitis

Mlingo umodzi wa 500 mg

Orchoepididymitis ndi zotupa matenda amchiberekero

Osachepera masiku 14

Matenda am'mimba komanso matenda amtumbo

Kutsekula m'mimba koyambitsidwa ndi kachilombo ka bakiteriya, kuphatikiza Shigella spp, kupatula mtundu wa Shigella dysenteriae I ndi chithandizo chamankhwala cham'mimba chovuta kwambiri

Kutsegula m'mimba koyambitsidwa ndi Shigella dysenteriae Type I

Vibrio chlera m'mimba

Matenda a grram-intra-m'mimba

Khungu ndi matenda ofewa a minofu

Matenda ophatikizika ndi mafupa

Kupewa komanso kuchiza matenda kwa odwala omwe ali ndi neutropenia. Analimbikitsa kucheza ndi mankhwala ena

Mankhwalawa akupitiliza mpaka kumapeto kwa nthawi ya neutropenia.

Kupewa matenda obwera chifukwa cha Neisseria meningitides

Postexposure prophylaxis ndi mankhwala a anthrax. Chithandizo chiyenera kuyambitsidwa mwachangu pambuyo poti wakayikira kapena watitsimikizira kuti watenga kachilomboka.

Masiku 60 kuchokera pa chitsimikiziro

Kwa odwala okalamba, mlingo umachepetsedwa ndi 30%.

Odwala omwe ali ndi vuto la chiwindi: Kusintha kwa mankhwalawa sikofunikira.

Odwala ndi mkhutu aimpso ntchito: mlingo umasinthidwa malinga ndi tebulo:

250-500 mg kamodzi pa maola 24 aliwonse

250-500 mg 1 nthawi pakatha maola 24 pambuyo pa dialysis

Zotsatira zoyipa

Pa khungu ndi subcutaneous minofu: erythema multiforme ndi nodosum.

Kuchokera pamtima: kutalika kwa nthawi ya QT, ventricular arrhythmias (kuphatikizapo mtundu wa pirouette), vasculitis, kuyaka kwamoto, migraine, kukomoka.

Kuchokera m'mimba ndi chiwindi: chisawawa, anorexia.

Kuchokera kumbali yamanjenje ndi psyche: intracranial matenda oopsa, kusowa tulo, kusokonezeka, kugwedezeka, zosowa zambiri, zotumphukira zakukhosi, thukuta, paresthesia ndi kukomoka, kulumikizana, kusokonezeka, kukhumudwa, mantha komanso kununkhira. zosokoneza zowoneka (diplopia, chromatopsia), tinnitus, kumva kwakanthawi kwamakutu. Zitachitika izi, musiyeni, musiyeni.

Kuchokera ku hemopoietic system: thrombocytopenia, kawirikawiri - leukocytosis, thrombocytosis, hemolytic anemia, anemia, agranulocytosis, pancytopenia (yowopseza moyo), kupsinjika kwa m'mafupa (kuwopseza moyo).

Thupi lawo siligwirizana ndi immunopathological: Mankhwala, komanso photosensitization, osakhala bronchospasm, osowa kwambiri anaphylactic, myalgia, matenda a Lyell, interstitial nephritis, hepatitis.

Makina a minofu ndi mafupa: nyamakazi, kukweza minofu kamvekedwe ndi kukokana. Osowa kwambiri - kufooka kwa minyewa, tendonitis, kupindika kwa tendon (makamaka Achilles tendon), kukulitsa kwa zizindikiro za myasthenia gravis.

Ziwalo zopumira: kupuma movutikira (kuphatikiza zochitika za mphumu).

Mulingo wambiri: asthenia, kutentha thupi, kutupa, thukuta (hyperhidrosis).

Kukhudzika kwazizindikiro za labotale: hyperglycemia, kusintha kwa kuchuluka kwa prothrombin, kuwonjezeka kwa zochitika za amylase.

Zolemba ntchito

Musanayambe chithandizo, pitani kuchipatala!

Ngati kutsegula m'mimba kwambiri kwakanthawi komanso pakapita nthawi, pitani kuchipatala msanga.

Ngati pali zowawa m'misempha, muyenera kusiya kumwa mankhwalawo ndikuwonana ndi dokotala.

Kukopa pa kuyendetsa galimoto ndikugwira ntchito ndi zinthu

Pa chithandizo, munthu ayenera kupewa kuchita zinthu zomwe zingakhale zovulaza zomwe zimafunikira chidwi chochulukirapo komanso kuthamanga kwa malingaliro ndi magalimoto.

Njira zopewera kupewa ngozi

Matenda akulu a ziwongo, ziwopsezo zam'mimba, matenda amisala, matenda amtundu, khunyu, aimpso komanso / kapena kulephera kwa chiwindi, ukalamba.

Mavuto a mtima. Ciprofloxacin iyenera kugwiritsidwa ntchito mosamala kuphatikiza ndi mankhwala omwe amawonjezera nthawi ya QT (mwachitsanzo, mankhwala a kalasi I ndi III antiarrhythmic), kapena odwala omwe ali ndi chiopsezo chowonjezeka cha mtundu wa pirouette arrhythmias (mwachitsanzo, ndi kutalika kwodziwika kwa gawo la QT, kukonza hypokalemia).

Musculoskeletal system.Pazizindikiro zoyambirira za tendonitis (kutupa kwakupweteka pakulowa, kutupa), kugwiritsa ntchito ciprofloxacin kuyenera kuyimitsidwa, zolimbitsa thupi ziyenera kuthiridwa, chifukwa pali chiopsezo chotumphukira kwa tendon, ndikuwonana ndi dokotala. Ciprofloxacin iyenera kugwiritsidwa ntchito mosamala odwala omwe amatenga ma steroid omwe ali ndi mbiri ya matenda a tendon omwe amagwirizana ndi quinolones.

Ciprofloxacin imakulitsa kufooka kwa minofu kwa odwala omwe ali ndi myasthenia gravis.

Gwiritsani ntchito mosamala ngati pali mbiri yakusowa kwa matenda, matenda amisala (kukhumudwa, psychosis), kulephera kwaimpso (komanso motsutsana ndi kulephera kwa chiwindi). Mwakamodzikamodzi, matenda amisala amawonekera chifukwa chofuna kudzipha. Muzochitika izi, muyenera kusiya kumwa ciprofloxacin ndi kudziwitsa dokotala.

Mukamamwa ciprofloxacin, zimachitika m'maso, motero odwala ayenera kupewa kulumikizana ndi dzuwa kapena kuwala kwa UV. Kuchiza pamilandu iyi kuyenera kusiyidwa.

Muyenera kusamala mukamagwiritsa ntchito ciprofloxacin ndi theophylline, methylxanthine, khofi, duloxetine, clozapine, chifukwa kuwonjezeka kwa kuchuluka kwa mankhwalawa m'magazi kungayambitse zovuta zina.

Popewa kukula kwa crystalluria, mlingo womwe umalimbikitsidwa tsiku lililonse sayenera kupitirira, kukhathamiritsa madzi okwanira ndikusunga mkodzo wa acid acid ndikofunikira.

Pharmacokinetics

Ukamamwa pakamwa, ciprofloxacin imatsala pang'ono kutuluka komanso kugwirira msanga m'mimba (makamaka mu jejunum ndi duodenum). Kudya kumalepheretsa mayamwidwe, koma sikukhudza bioavailability ndi pazere kwambiri. Bioavailability ndi 50-85%, ndipo voliyumu yogawa ndi 2-3.5 l / kg. Ciprofloxacin imamangiriza mapuloteni a plasma ndi pafupifupi 20-40%. Mulingo wokwanira wa chinthu mthupi ukatengedwa pakamwa umapezeka pambuyo pafupifupi mphindi 60-90. Kuzindikira kwakukulu kumakhala kofanana ndi mlingo womwe umatengedwa ndi Mlingo wa 1000, 750, 500 ndi 250 mg ndi 5.4, 4.3, 2.4 ndi 1.2 μg / ml, motsatana. Maola 12 atamwa 750, 500 ndi 250 mg, zomwe zili za profrofloxacin mu plasma zimachepetsedwa kukhala 0,4, 0,2 ndi 0,1g / ml, motsatana.

Thupi limagawidwa mokwanira mu minofu ya thupi (kupatula minofu yolimbitsa mafuta, mwachitsanzo, minyewa yamitsempha). Zomwe zimakhala mu minofu ndizochulukirapo kawiri ndi kawiri kuposa madzi am'magazi. Zochitika zochizira zimapezeka pakhungu, malovu, zotumphukira, ma cellil, ma cartilage ofanana ndi zotumphukira, mafupa ndi minyewa, matumbo, chiwindi, ndulu, chikhodzodzo, impso ndi kwamikodzo, ziwalo zam'mimba komanso zotupa za m'mimba. machubu, endometrium), zimakhala za prostate, zotupa zam'mimba, zotupa za bronchial, minofu yam'mapapo.

Ciprofloxacin imalowa m'magazi a cerebrospinal m'magawo ang'onoang'ono, pomwe zinthu zake ndizosagwirizana ndi mankhwalawa ndi 6-10% ya izo mu seramu yamagazi, ndipo ndi yotupa yokhayo yomwe ilipo, ndi 14- 37%.

Ciprofloxacin imalowanso mkati mwanabele, pleura, ocular fluid, peritoneum kudzera mwa placenta. Kuphatikiza kwake mu neutrophils wamagazi ndi 2-7 kuposa nthawi ya seramu. Pulogalamuyo imapangidwira m'chiwindi ndi 15-30%, ndikupanga metabolites osagwira (formylcycrofloxacin, diethylcycrofloxacin, oxociprofloxacin, sulfociprofloxacin).

Hafu ya moyo wa ciprofloxacin ndi pafupifupi maola 4, ndipo kulephera kwaimpso kumawonjezeka mpaka maola 12. Imafukusidwa makamaka kudzera mu impso kudzera mu tubular secretion ndi machulukitsidwe a tubular mu mawonekedwe osasinthika (40-50%) komanso mu mawonekedwe a metabolites (15%), ena onse amamuona kudzera m'mimba. Kuchuluka kwa ciprofloxacin kumachotsedwa mkaka wa m'mawere. Chilolezo cha impso ndi 3-5 ml / min / kg, ndipo chilolezo chonse ndi 8-10 ml / min / kg.

Kulephera kwa aimpso (CC oposa 20 ml / mphindi), kuchuluka kwa kuchulukitsidwa kwa ciprofloxacin kudzera mu impso kumatsika, koma sikumachitika mthupi chifukwa chakuwonjezeka kwa kagayidwe kake ka chinthuchi ndi kuphipha kwake kudzera m'mimba.

Mukamachita kulowetsedwa kwa mankhwala osokoneza bongo mu 200 mg, pazipita ndende ya ciprofloxacin ya 2.1 μg / ml imatheka pambuyo pa mphindi 60. Pambuyo pokonzekera mtsempha wa magazi, zomwe zili mumkodzo mumkodzo patangotha maola 2 atatha kulowetsedwa zimakhala pafupifupi 100 nthawi yayikulu kuposa m'magazi am'magazi, omwe amapitilira kuchuluka kwa ma inhibitory ambiri chifukwa cha tizirombo toyambitsa matenda.

Ikagwiritsidwa ntchito mopyola, ciprofloxacin imalowa mu ziwalo za diso: chipinda chamkati ndi ziphuphu, makamaka kuwonongeka kwa corneal epithelium. Ikawonongeka, chinthucho chimadziunjikira mkati mwake momwe chimatha kuwononga ambiri oyambitsa matenda a corneal.

Pambuyo pakukhazikitsa kamodzi, zomwe zili profrofloxacin mu chinyezi cha chipinda chamkati chamaso chimatsimikizika pambuyo pa mphindi 10 ndipo ndi 100 μg / ml. Kuchuluka kwazomwe kumapangitsa kuti pakhale chinyezi cha chipinda chamkati kumafikira pambuyo pa ola limodzi ndipo ndikofanana ndi 190 μg / ml. Pambuyo pa maola 2, ndende ya ciprofloxacin imayamba kuchepa, koma mphamvu yake ya antibacterial m'mitsempha yama corneal imakhala nthawi yayitali ndipo imatha kwa maola 6, mu chinyezi cha chipinda chamkati - mpaka maola 4.

Pambuyo pokhazikitsa, kuyamwa kwachilengedwe kwa ciprofloxacin kumawonedwa. Mukamagwiritsa ntchito mawonekedwe amaso amatsikira kanayi pa tsiku m'maso onse kwa masiku 7, pafupifupi kuchuluka kwa zinthu m'magazi am'magazi sikupitirira 2-2.5 ng / ml, ndipo kuchuluka kwa ndende kumakhala kochepa kuposa 5 ng / ml.

Kugwiritsa ntchito kwadongosolo (mapiritsi, njira yothetsera kulowetsedwa, konzekerani pokonzekera yankho la kulowetsedwa)

Kwa odwala akuluakulu, ciprofloxacin amagwiritsidwa ntchito pochiza komanso kupewa matenda opatsirana komanso otupa oyambitsidwa ndi tizilombo tating'onoting'ono:

bronchitis (aakulu pachimake pachimake ndi pachimake), bronchiectasis, chibayo, cystic fibrosis ndi matenda ena kupuma.
frontitis, sinusitis, pharyngitis, otitis media, sinusitis, tonsillitis, mastoiditis ndi matenda ena a ziwalo za ENT,
pyelonephritis, cystitis ndi matenda ena a impso ndi kwamkodzo thirakiti.
adnexitis, gonorrhea, prostatitis, chlamydia ndi matenda ena amkati ndi ziwalo zamkati,
mabakiteriya zotupa zam'mimba (m'mimba thirakiti), ndulu za ndulu, chimbudzi, ndi zotupa zina zam'mimba,
zilonda zam'mimba, kuwotcha, zilonda, mabala, chifuwa ndi zotupa zina pakhungu ndi minofu yofewa.
nyamakazi ya septic, osteomyelitis ndi matenda ena am'mafupa ndi mafupa,
opaleshoni (pofuna kupewa matenda),
Anthrax ya pulmonary (kupewa ndi kuchiza),
matenda motsutsana maziko a chitetezo chokwanira chifukwa cha mankhwala omwe ali ndi mankhwala a immunosuppress kapena neutropenia.

Kwa ana azaka zapakati pa 5 mpaka 17, Ciprofloxacin amalembedwa mwatsatanetsatane kwa pulmonary cystic fibrosis pochizira zovuta zomwe zimayambitsidwa ndi Pseudomonas aeruginosa, komanso kupewa ndi kuchiza pulmonary anthrax (Bacillus anthracis).

Njira yothetsera kulowetsedwa ndi kusunthika pakukonzekera njira yothetsera kulowetsedwa imagwiritsidwanso ntchito ngati matenda a maso ndi matenda akuthupi ambiri - sepsis.

Mapiritsi amalembedwa kwa KFOR (kusankha matumbo decontamination) kwa odwala omwe ali ndi chitetezo chokwanira.

Kugwiritsa ntchito pamutu (madontho amaso, maso ndi khutu)

Madontho a Ciprofloxacin amagwiritsidwa ntchito pochizira komanso kupewa matenda opatsirana omwe amayambitsidwa ndi tizilombo tating'onoting'ono tokhudza chiprofloxacin:

ophthalmology (madontho amaso, makutu amaso ndi khutu): blepharitis, subacute ndi pachimake conjunctivitis, blepharoconjunctivitis, keratitis, keratoconjunctivitis, meibomite (balere), dacryocystitis yodutsitsa, matenda a bakiteriya am'mimba, matenda opatsirana chifukwa cha vuto la diso. opaleshoni yamaso
otorhinolaryngology (madontho amaso ndi khutu): otitis media yakunja, chithandizo cha matenda opatsirana pambuyo pake.

Mapiritsi okhala ndi mafilimu

Mapiritsi a Ciprofloxacin amatengedwa pakamwa pambuyo pa chakudya, kumeza lonse, ndi madzi pang'ono. Kumwa mapiritsi pamimba yopanda kanthu kumathandizira kuyamwa kwa chogwira ntchito.

Mlingo woyenera: 250 mg katatu patsiku, ndi matenda oopsa - 500-750 mg 2 kawiri pa tsiku (1 nthawi mu maola 12).

Mlingo wokhudza matenda / zikhalidwe:

matenda a kwamkodzo thirakiti: kawiri pa tsiku, 250-500 mg pakapita masiku 7 mpaka 10,
Matenda a prostatitis: kawiri patsiku 500 mg kwa masiku 28,
gonorrhea wovuta: 250-500 mg kamodzi,
Matenda a gonococcal osakanikirana ndi chlamydia ndi mycoplasmosis: kawiri pa tsiku (nthawi 1 m'mawola 12) 750 mg mwanjira kuyambira masiku 7 mpaka 10,
chancroid: kawiri pa tsiku, 500 mg kwa masiku angapo,
meningococcal kunyamula mu nasopharynx: 500-750 mg kamodzi,
Matumbo onyamula nsomba: kawiri pa tsiku, 500 mg iliyonse (ngati pangafunike, onjezerani ku 750 mg) pakapita masiku 28,
matenda oopsa (obwerezanso cystic fibrosis, matenda am'matumbo, mafupa, mafupa) oyambitsidwa ndi pseudomonads kapena staphylococci, chibayo cham'mimba chifukwa cha streptococci, chlamydial matenda amtundu wa genitourinary: kawiri pa tsiku (1 nthawi mu maola 12) pa mlingo wa 750 mg (njira ya mankhwalawa osteomyelitis itha kukhala mpaka masiku 60)
matenda am`mimba thirakiti chifukwa Staphylococcus aureus: kawiri pa tsiku (1 nthawi maola 12) pa mlingo wa 750 mg pakapita masiku 7 mpaka 28,
Pseudomonas aeruginosa wa ana a zaka 5 mpaka 17 ndi pulmonary cystic fibrosis: kawiri patsiku 20 mg / kg (mlingo waukulu wa tsiku lililonse - 1500 mg) pakatha masiku 10 mpaka 14,
anthrax ya pulmonary (chithandizo ndi kupewa): kawiri tsiku lililonse kwa ana 15 mg / kg, achikulire 500 mg (Mlingo wokwanira: limodzi - 500 mg, tsiku lililonse - 1000 mg), njira ya mankhwalawa - mpaka masiku 60, ayambe kumwa mankhwalawa Iyenera kuchitika pambuyo poti wadwala (akuganiza kapena kutsimikiziridwa).

Mulingo wambiri watsiku ndi tsiku wa ciprofloxacin mu kulephera kwa impso:

creatinine chilolezo (CC) 31-60 ml / mphindi / 1.73 m 2 kapena seramu creatinine ndende ya 1.4-1.9 mg / 100 ml - 1000 mg,
KK 2 kapena serum creatinine ndende> 2 mg / 100 ml - 500 mg.

Odwala a hemo- kapena peritoneal dialysis ayenera kumwa mapiritsi atatha dialysis gawo.

Okalamba odwala amafunika kuchepetsa 30%.

Njira yothetsera kulowetsedwa, konzekera kwambiri pokonzekera yankho la kulowetsedwa

Mankhwalawa amaperekedwa kudzera m'mitsempha, pang'onopang'ono, mumitsempha yayikulu, izi zimachepetsa chiopsezo cha zovuta m'malo a jakisoni. Ndi kuyambitsa 200 mg ya ciprofloxacin, kulowetsedwa kumatenga mphindi 30, 400 mg - 60 Mphindi.

Musanagwiritse ntchito, gwiritsani ntchito kukonzekera njira yothetsera kulowetsedwa kuyenera kuchepetsedwa mpaka 50 mamilimita mu njira zotsatirazi: 0.9% sodium kolorayidi, yankho la Ringer, 5% kapena 10% dextrose solution, 10% yankho la fructose, 5% dextrose yankho ndi 0.225 -0.45% sodium kolorayidi njira.

Yankho la kulowetsedwa limayendetsedwa lokha kapena limodzi ndi mayankho ofananirana kulowetsedwa: 0,9% sodium kolorayidi, Ringer ndi Ringer Lactate solution, 5% kapena 10% dextrose solution, 10% fructose solution, 5% dextrose solution kuchokera pa 0.225-0.45 % yankho la sodium kolorayidi. Njira yothetsera vutoli itasakanikirana iyenera kugwiritsidwa ntchito mwachangu kuti ikhalebe yolimba.

Ngati pali kusagwirizana kosagwirizana ndi yankho lina / mankhwala, njira ya kulowetsedwa kwa ciprofloxacin imayendetsedwa mosiyana. Zizindikiro zowoneka zosagwirizana ndi kupendekera kwamtambo, kutentha kapena kusinthasintha kwa madzi. Mlozera wa haidrojeni (pH) wa kulowetsedwa kwa ciprofloxacin ndi 3.5-4.6, motero, sugwirizana ndi mayankho onse / kukonzekera komwe kulibe thupi kapena mankhwala osakhazikika pamitengo ya pH (heparin solution, penicillins), makamaka ndi ma pH osintha mbali ya zamchere. Chifukwa chosungira yankho pamatenthedwe ochepa, kupangika kwa madzi osungunuka firiji ndikutheka. Sitikulimbikitsidwa kusunga yankho la kulowetsedwa mufiriji ndikuyimayimitsa, chifukwa yankho lokhalo komanso loonekera ndiloyenera kugwiritsidwa ntchito.

Mlingo wolimbikitsidwa wa ciprofloxacin wa akulu akulu:

matenda kupuma thirakiti: kutengera mkhalidwe wodwala ndi kuopsa kwa matenda - 2 kapena 3 pa tsiku, 400 mg aliyense,
matenda a genitourinary dongosolo: pachimake, osavuta - 2 kawiri pa tsiku mpaka 200 mg 400 mg, zovuta - 2 kapena katatu patsiku, 400 mg,
adnexitis, bacterial prostatitis, orchitis, epididymitis: 2 kapena katatu patsiku, 400 mg aliyense,
m'mimba: 2 kawiri pa tsiku, 400 mg aliyense,
matenda ena omwe adalembedwa mu gawo la "Zizindikiro Zakugwiritsa": 2 kawiri pa tsiku, 400 mg aliyense,
matenda oopsa oopsa, makamaka omwe amayamba chifukwa cha Staphylococcus spp., Preudomonas spp. ,
pulmonary (inhalation) mawonekedwe a anthrax: 2 kawiri pa tsiku, 400 mg pakapita masiku 60 (pochiza ndi kupewa).

Kuwongolera mlingo wa ciprofloxacin okalamba odwala kumachitika pansi, malingana ndi kuopsa kwa matendawa ndi chizindikiro cha QC.

Zochizira ana a zaka 5 mpaka 17, mavuto a Pseudomonas aeruginosa oyambitsidwa ndi pulmonary cystic fibrosis akulimbikitsidwa katatu pa tsiku 10 mg / kg (pazipita tsiku lililonse - 1200 mg) kwa masiku 10 mpaka 14. Zochizira ndi kupewa pulmonary anthrax, 2 infusions patsiku la 10 mg / kg ya ciprofloxacin akulimbikitsidwa (pazenera limodzi - 400 mg, tsiku lililonse - 800 mg), kumene - masiku 60.

Mulingo wambiri watsiku ndi tsiku wa ciprofloxacin mu kulephera kwa impso:

creatinine chilolezo (CC) 31-60 ml / mphindi / 1.73 m 2 kapena seramu creatinine ndende ya 1.4-1.9 mg / 100 ml - 800 mg,
KK 2 kapena serum creatinine ndende> 2 mg / 100 ml - 400 mg.

Kwa odwala pa hemodialysis, ciprofloxacin imayendetsedwa pambuyo pa maphunzirowa.

Nthawi yayitali ya mankhwala:

gonorrhea wovuta - 1 tsiku,
matenda a impso, kwamikodzo thirakiti ndi m'mimba - mpaka masiku 7,
osteomyelitis - osaposa masiku 60,
matenda a streptococcal (chifukwa cha kuopsa kwa zovuta zaposachedwa) - osachepera masiku 10,
matenda motsutsana maziko a chitetezo chokwanira chifukwa cha mankhwala omwe ali ndi immunosuppress mankhwala - panthawi yonse ya neutropenia,
matenda ena - masiku 7-14.

Diso likugwetsa, diso ndi khutu

Muzochita za ophthalmic, madontho a ciprofloxacin (ophthalmic, ophthalmic ndi khutu) amaikidwa mu gawo la conjunctival sac.

Malangizo othandizira kutengera mtundu wa matenda ndi kuuma kwa njira yotupa:

pachimake bakiteriya conjunctivitis, blepharitis (yosavuta, scaly ndi ulcerative), meibomites: 1-2 imatsika 4-8 pa tsiku kwa masiku 5-14,
keratitis: dontho limodzi kuchokera 6 pa tsiku kwa masiku 14-31,
zilonda zam'magazi mabakiteriya: Tsiku 1 - 1 ligwetsere mphindi 15 zilizonse kwa maora 6 oyambilira, ndiye kuti mumaponya mphindi 30 zilizonse nthawi yakudzuka, tsiku lachiwiri - dontho limodzi 1 pakatha maola atatu masiku - pa maola ogalamuka, 1 dontho maola 4 aliwonse. Ngati epithelization sichinachitike pambuyo masiku 14 achithandizo, chithandizo chololedwa kupitiliza masiku ena 7,
dacryocystitis pachimake: 1 kusiya 6-12 pa tsiku limodzi ndi osapitilira masiku 14,
kuvulala kwamaso, kuphatikiza matupi akunja (kupewa matenda opatsirana): 1 dontho 4-8 pa tsiku kwa masiku 7-14,
Kukonzekera kwa wogwira: 1 dontho kanayi kwa tsiku kwa masiku awiri musanayambe kugwira ntchito, dontho 1 kangapo ndi mphindi 10 musanayambe opareshoni,
postoperative nyengo (kupewa matenda opatsirana): 1 dontho katatu pa tsiku kwa nthawi yonseyi, kuyambira masiku 5 mpaka 30.

Mu otorhinolaryngology, mankhwalawa (maso ndi khutu akutsikira) amaikidwa mu ngalande yakunja, atayeretsa kale mosamala.

Malangizo othandizira a dosing: 2-5 kawiri pa tsiku (kapena pafupipafupi, ngati ndikofunikira) madontho a 3-4. Kutalika kwa mankhwalawa sikuyenera kupitilira masiku 5 mpaka 10, pokhapokha ngati malowo ndi omasuka, ndiye kuti maphunzirowo akuloledwa.

Mwa njirayi, tikulimbikitsidwa kubweretsa njira yothetsera kutentha kwa chipinda kapena kutentha kwa thupi pofuna kupewa kukondoweza. Wodwalayo ayenera kugona pambali pake, moyang'anizana ndi khutu lomwe lakhudzidwa, ndikukhalabe m'malo ano kwa mphindi 5 mpaka 10 ataphunzitsidwa.

Nthawi zina, pambuyo pakuyeretsa kwapanja kunja kwa ngalande, imaloledwa kuyika thonje swab choviikidwa mu njira ya Ciprofloxacin mu khutu ndikuisunga pamenepo mpaka kuphunzitsidwa kwotsatira.

Kuyanjana kwa mankhwala

Chifukwa cha kuchuluka kwa mankhwala opangidwa ndi mankhwala a Ciprofloxacin komanso kuopsa kwa mayanjano omwe amapezeka ndi mankhwala, lingaliro la zomwe angathe kuphatikizidwa ndi mankhwala ena osokoneza bongo amapangidwa ndi adotolo.

Mndandanda wa ciprofloxacin mwanjira yamapiritsi: Quintor, Procipro, Ceprova, Ciprinol, Ciprobay, Ciprobid, Ciprodox, Ciprolet, Cipropan, Cifran, ndi ena.

Mitu yankho la kulowetsedwa ndikuyang'ana kukonzekera njira yothetsera kulowetsedwa kwa Ciprofloxacin: Basigen, Ififpro, Quintor, Procipro, Tseprova, Ciprinol, Tsiprobid, ndi ena.

Mndandanda wa ophthalmic / ocular ndi khutu umatsika Ciprofloxacin: Betaciprol, Rocip, Ciprolet, Ciprolon, Cipromed, Ciprofloxacin-AKOS.

Migwirizano ndi magwiritsidwe akusungidwa

Sungani pamalo owuma, amdima pamatenthedwe mpaka 25 ° C, yankho la kulowetsedwa, gwiritsani ntchito mankhwalawa ndikutsikira - musazizire. Pewani kufikira ana.

Alumali moyo wamapiritsi ndi kuyambira zaka 2 mpaka 5 (kutengera wopanga), yankho ndikuchita mozama - zaka 2, diso / diso ndi khutu limatsika - zaka zitatu.

Mutatsegulira botolo, masheya amaso ndi khutu osaposa masiku 28, diso limatsika osaposa masiku 14.

250 kapena 500 mg mapiritsi

Mapiritsi ayenera kumwedwa pamimba yopanda kanthu, osafuna kutafuna ndikumwa ndi madzi. Mlingo wovomerezeka wa mankhwalawa ndi 250 mg katatu patsiku. Mu matenda oopsa, tikulimbikitsidwa kumwa mankhwala a 500-750 mg maola 12 aliwonse (kawiri pa tsiku).

Mlingo wovomerezeka wa ciprofloxacin zimatengera mtundu wamatenda, kuuma kwa matendawa, mkhalidwe wa thupi, impso, kulemera ndi msinkhu wa wodwalayo.

Pochiza matenda osavuta a impso ndi kwamikodzo, 250 mg ya Ciprinol iyenera kumwedwa kawiri pa tsiku kwa masiku 7-10, ndi matenda osavuta - 500 mg kawiri pa tsiku kwa masiku atatu.

Aakulu matenda a prostatitis, 500 mg ya mankhwala zotchulidwa 2 pa tsiku kwa masiku 28.

Zochizira matenda opatsirana komanso otupa a m'munsi kupuma kwamphamvu kwambiri, tikulimbikitsidwa kumwa 250-500 mg wa Ciprinol 2 kawiri pa tsiku. Mankhwalawa milandu yambiri, mlingo umakulitsidwa 750 mg 2 kawiri pa tsiku.

Mu chinzonono chachikulu, muyezo umodzi wa 250-500 mg wa ciprofloxacin ndi mankhwala. Ngati matenda a gonococcal aphatikizidwa ndi mycoplasma ndi chlamydia, ndiye kuti mankhwalawa ndi 750 mg wa mankhwalawa maola 12 aliwonse (nthawi ya makonzedwe akuchokera masiku 7 mpaka 10).

Ndi chancroid, tikulimbikitsidwa kutenga 500 mg ya Ciprinol 2 kawiri pa tsiku kwa masiku angapo.

Mlingo umodzi wa ciprofloxacin wokhala ndi Salmonellatyphi ndi 250 mg, komabe, ngati pangafunikire, utha kuwonjezeka mpaka 500 kapena 750 mg. Pafupipafupi kuvomereza ndi 2 kawiri pa tsiku, kutalika kwa maphunzirowa mpaka milungu 4.

Matenda opatsirana a m'mimba, osteomyelitis ndi matenda ena akulu, 750 mg ya mankhwalawa amatchulidwa 2 pa tsiku. Njira ya mankhwalawa osteomyelitis imatha kupitilira miyezi iwiri.

Kuthana ndi matenda am'mimba oyambitsidwa ndi Staphylococcus aureus, 750 mg wa Ciprinol ayenera kutengedwa maola 12 aliwonse masiku 7 mpaka 28.

Ndi matenda a m'mimba mwa apaulendo, 500 mg ya ciprofloxacin imayikidwa 2 pa tsiku kwa masiku 5-7 (nthawi zina mpaka masiku 14).

Mu matenda a khutu, mmero ndi mphuno, mlingo zimatengera kuopsa kwa matendawa: zolimbitsa - kuchokera 250 mpaka 500 mg, kwambiri - kuchokera 500 mpaka 750 mg. Mankhwala amatengedwa 2 pa tsiku.

Zochizira zamavuto obwera chifukwa cha Pseudomonas aeruginosa mu ana omwe ali ndi pulmonary cystic fibrosis kuyambira zaka 5 mpaka 17, tikulimbikitsidwa kugwiritsa ntchito ciprofloxacin pa mlingo wa 20 mg pa 1 kg ya kulemera (mlingo waukulu ndi 1500 mg). Zikatero, Ciprinol amatengedwa katatu patsiku kwa masiku 10-14.

Poletsa matenda opaleshoni, 500-750 mg wa Ciprinol ndi mankhwala 1-1.5 mawola asanachite opareshoni.

Pofuna kupewa ndi kuchiza matenda a anthrax, odwala okalamba amapatsidwa 500 mg ya ciprinol 2 pa tsiku, ana - 15 mg ya ciprofloxacin pa 1 makilogalamu a thupi kawiri pa tsiku. Ndikofunikira kuyamba kumwa mankhwalawa mutangotenga kachilombo (mukumaganizira kapena kutsimikiziridwa). Pa gawo loyamba la chithandizo, ndikofunikira kugwiritsa ntchito mitundu ya makolo. Kutalika konse kwa chithandizo ndi masiku 60.

Nthawi zambiri, njira yochizira mankhwalawa imayamba masiku 7 mpaka 10, mutatha kutentha, ndikofunikira kutenga Ciprinol masiku ena atatu.

Odwala ovuta a aimpso ntchito ayenera kulandira theka la mankhwala. Mankhwalawa odwala aimpso kulephera, mlingo wotsatira akulimbikitsidwa:

KK woposa 50 ml / mphindi - mlingo wamba,
CC kuchokera 30 mpaka 50 ml / mphindi - kuchokera 250 mpaka 500 mg wa Ciprinol kamodzi pa maola 12 aliwonse,
KK kuyambira 5 mpaka 29 ml / mphindi - kuchokera 250 mpaka 500 mg ya mankhwalawa kamodzi pa maola 18 aliwonse,
odwala akudwala peritoneal dialysis kapena hemodialysis - kuchokera 250 mpaka 500 mg ya ciprofloxacin 1 nthawi maola 24

Mapiritsi 750 mg

Mapiritsi ayenera kumwedwa mutatha kudya, osafuna kutafuna ndikumwa ndi madzi. Mlingo wovomerezeka wa ciprofloxacin zimatengera mtundu wamatenda, kuuma kwa matendawa, mkhalidwe wa thupi, impso, kulemera ndi msinkhu wa wodwalayo.

Ngati matenda opatsirana komanso otupa a m'munsi kupuma kwamphamvu kwambiri 2 pa tsiku, 750 mg ya mankhwala ndi mankhwala.

Ndi pyelonephritis yovuta, tikulimbikitsidwa kutenga 750 mg 2 kawiri pa tsiku. Njira ya mankhwalawa imachokera masiku 10, ndipo mwapadera (mwachitsanzo, ndi chala cha impso), nthawi yayitali ingathe kupitirira masiku 21.

Odwala kwambiri pakhungu ndi minofu yofewa, mankhwalawa amatengedwa 2 pa tsiku kwa 750 mg. Njira ya mankhwala ndi masiku 7-14.

Woopsa m'matenda a mafupa ndi olowa (septic nyamakazi, osteomyelitis), 750 mg wa Ciprinol ndi mankhwala 2 kawiri pa tsiku. Kutalika kwa mankhwala a osteomyelitis mpaka miyezi iwiri.

Pa matenda a ziwalo zoberekera ndi ziwalo za m'chiberekero, mankhwalawa amalimbikitsidwa kuti amwe kawiri pa tsiku, 750 mg aliyense.

Kwa matenda am'mimbamo chifukwa cha bakiteriya wopanda gramu, pafupipafupi kumwa ciprofloxacin ndi 2 kawiri pa tsiku pa 750 mg.

Mu nkhani ya matenda motsutsana ndi maziko a chitetezo chokwanira, mankhwalawa ndi mankhwala limodzi ndi antibacterial wothandizira 2 pa tsiku, 750 mg aliyense.

Pa prophlaxis yamatenda pakuchita opareshoni, ma 1-1.5 maola asanalowe, kumenyedwa kwa 500-750 mg wa ciprofloxacin akusonyezedwa.

Kukula kwa matendawa kumakhudza nthawi yayitali ya chithandizo, mutatha kutentha matendawa, mankhwala ayenera kupitilizidwa kwa masiku ena atatu. Kutalika kwa nthawi yotalikirana ndi masiku 7-10.

Gwiritsani ntchito paubwana

Poletsa ndi kuchiza matenda a pulmonary anthrax ana a zaka 5 mpaka 17, 10 mg ya ciprofloxacin pa 1 kg ya kulemera kwa thupi imayikidwa 2 pa tsiku. Mlingo wapamwamba wa tsiku ndi tsiku wothandizidwa ndi intravenous makonzedwe a 800 mg (mlingo umodzi wapamwamba ndi 400 mg).

Odwala omwe ali ndi pulmonary cystic fibrosis ya ana a zaka 5 mpaka 17, mankhwalawa omwe amayamba chifukwa cha Pseudomonas aeruginosa, 10 mg ya ciprofloxacin pa 1 mg wa thupi lililonse amalembetsa maola 8 aliwonse. Njira ya mankhwalawa ndi kuyambira masiku 10 mpaka 14.

Ndi mkhutu aimpso ntchito

Odwala omwe atchulidwa kuti aimpso ntchito ayenera kulandira theka la mankhwalawa (onani "Mlingo ndi Ulamuliro: Mapiritsi a 250 ndi 500 mg").

Ndi serum creatinine ndende pakati pa 1.4 / 100 ml ndi 1.9 mg / 100 ml kapena chilolezo cha creatinine cha 31 ml / mphindi / 1.73 sq. mpaka 60 ml / mphindi / 1,73 sq. m, mlingo woyenera wa tsiku ndi tsiku wa mankhwala ndi 800 mg.

Zochizira odwala kwambiri aimpso kulephera (kulengedwa kwa creatinine - mpaka 30 ml / mphindi / 1,73 sq. M, creatinine ndende - oposa 2 mg / 100 ml), theka la tsiku tsiku lililonse (osapitirira 400 mg patsiku). Ndi peritonitis mu odwala a kunja kwa peritoneal dialysis, n`zotheka kuperekera chiprofloxacin intraperitoneally 4 pa tsiku, 50 mg pa 1 lita imodzi ya dialysate.

Ndemanga pa Ciprinol

Kuwunikira kwa Ciprinol kumawonetsa kugwira ntchito kwa mankhwalawa - kumathandiza kuthana ndi matenda omwe adayambitsa matendawa. Nthawi yomweyo, ogwiritsa ntchito ambiri amakamba za zoyipa (kufooka kwa ziwerengero zamagazi a labotale, matenda oyamba ndi fungus, dysbiosis). Amadziwika kuti mankhwalawa amayenera kumwedwa kokha panthawi yomwe dokotala watchulidwa.

Kodi mwapeza cholakwika m'mawuwo? Sankhani ndikusindikiza Ctrl + Lowani.

Kupanga ndi mawonekedwe a kumasulidwa

Mankhwalawa amapezeka m'mitundu ingapo - madontho amaso ndi khutu, mapiritsi, jakisoni, mafuta amaso. Malinga ndi malangizo, maziko a zonsezi ndi ciprofloxacin hydrochloride. Mlingo wa chinthu ichi ndi zinthu zina zothandizira ndi zomwe zimasiyana. Kamangidwe ka mankhwala akufotokozedwa pagome:

Fomu la kumasulidwa kwa Ciprofloxacin (dzina lachi Latin - ciprofloxacin)

Mapiritsi ogwiritsira ntchito pakamwa

250, 500 kapena 750 mg

Chophimba ndi zokutira filimu, mawonekedwewo zimatengera wopanga ndi kipimo.

silika colloidal owononga madzi,

Diso ndi khutu zimatsika 0,3%

Mtundu wopanda khungu, wowonekera kapena pang'ono wachikasu. Wogulitsa ma polyper dontho mabotolo 1 a katoni.

Kulowetsedwa ampoule yankho la otsikira

Makina osawoneka bwino kapena amtundu pang'ono m'mbale 100 ml.

kuchepetsa hydrochloric acid,

Amapezeka m'matumba a aluminiyamu, omwe amamangidwa m'makatoni.

Tsatirani njira yothetsera kulowetsedwa

Pang'ono pang'ono chikasu kapena chikasu chowonekera cha 10 ml m'botolo. Amagulitsidwa mzidutswa 5 papaketi iliyonse.

disodium edetate dihydrate,

madzi a jakisoni

Mankhwala

Malinga ndi malangizo, mitundu yonse ya mankhwalawo imakhala ndi antibacterial wodziwika bwino pothana ndi gram-positive ndi gram-negative aerobic ndi anaerobic bacteria, monga:

Chifuwa chachikulu cha mycobacterium,
Brucella spp.,
Listeria monocytogene,
Mycobacterium kansasii,
Chlamydia trachomatis,
Legionella pneumophila,
Mycobacterium avium-intracellulare.

Staphylococci yogonjetsedwa ndi methicillin samva chidwi ndi ciprofloxacin. Zosagwirizana ndi Treponema pallidum. Streptococcus pneumoniae ndi mabakiteriya a Enterococcus faecalis amatha chidwi ndi mankhwalawo. Mankhwalawa amagwira ntchito pa ma tizilombo tating'onoting'ono poletsa DNA yawo ndikupondereza gyrase ya DNA. The yogwira thunthu limalowa bwino mu madzi madzimadzi, minofu, khungu, bile, plasma, mwanabele. Pambuyo ntchito mkati, bioavailability ndi 70%. Mafuta a zigawo zikuluzikulu amakhudzidwa pang'ono ndi chakudya.

Mlingo ndi makonzedwe

Malangizo amadziwika ndi mtundu komanso kuuma kwa matendawa. Ciprofloxacin - malangizo ake ogwiritsira ntchito akuwonetsa njira zitatu zogwiritsira ntchito. Mankhwalawa angagwiritsidwe ntchito kunja, mkati kapena ngati jakisoni. Ntchito yeniyeni imakhudzanso mlingo, ndipo nthawi zina msinkhu ndi thupi. Kwa okalamba ndi ana, ndizotsika kwambiri. Mukamwa mapiritsi, ndikofunikira kuti muzichita pamimba yopanda kanthu. Zingwe zimagwiritsidwa ntchito pazovuta kwambiri, kuti mankhwalawa amagwira ntchito mwachangu. Malinga ndi malangizo asanakhazikitsidwe, amayesedwa kuti adziwe ngati pathogenyo ilipo.

Zotsatira zoyipa ndi mankhwala osokoneza bongo

Ubwino wamitundu yonse yamankhwala ndi wololera bwino, koma odwala ena amakhalabe ndi zovuta monga:

mutu
kunjenjemera
chizungulire
kutopa
wokongola.

Izi nthawi zambiri zimakhala zoipa pogwiritsira ntchito chiprofloxacin. Malangizowo akuwonetseranso zovuta zina. Nthawi zina, odwala amatha:

intracranial matenda oopsa,
mafunde
thukuta
kupweteka m'mimba
kusanza kapena kusanza
chiwindi
tachycardia
kukhumudwa
Khungu
chisangalalo.

Poyerekeza ndi ndemanga, pokhapokha, odwala amakhala ndi bronchospasm, anaphylactic shock, Lyell syndrome, creatinine, vasculitis. akagwiritsidwa ntchito mu otology, mankhwalawa amatha kuyambitsa tinnitus, dermatitis, mutu. Kugwiritsa ntchito mankhwala kuchiritsa maso, mutha kumva:

kukhudzika kwa thupi lakunja pamaso, kusasangalala ndi kumva kuwawa,
Maonekedwe oyera ngati chovala chamkati kumaso,
conjunctival hyperemia,
lacure
kuchepa kowoneka bwino,
Photophobia
kutupa kwa matope,
Madera a ziphuphu.

Migwirizano yogulitsa ndikusunga

Mitundu yonse yotulutsira mankhwala imangoperekedwa pokhapokha ngati mwalandira mankhwala.Malo omwe asungirako ayenera kukhala ovuta kufikira ana ndi kuwayikira bwino. Malinga ndi malangizo, kutentha komwe kumalimbikitsa ndi kutentha kwa m'chipinda. Moyo wa alumali umatengera mawonekedwe a kumasulidwa ndipo ndi: