Leskol Forte

Chimodzi mwazinthu zamphamvu kwambiri zamankhwala otchedwa hypocholesterolemic lero ndi a Leskol Forte, malangizo omwe akuwonetsa kuti chida ichi ndicholinga choyeretsa mitsempha yamagazi ndikuchotsa lipids.

Matenda a mtima, omwe amachititsa kuti mafuta ambiri akhale m'magazi, amakhala m'gulu lamalo okwezeka kwambiri. Pafupifupi 20% ya imfa zolembedwa pachaka ndi ziwerengero zapadziko lonse lapansi ndi:

• matenda a mtima ndi zovuta zake,
• vuto la mtima.

Pamagulu omwe ali pachiwopsezo chotenga matendawa, choyambirira, ndikofunikira kubweretsa anthu pamavuto amitsempha yamagazi. Ndipo apa, cholesterol yoyipa imachita mbali yofunika kwambiri.

Ichi ndichifukwa chake akatswiri ambiri amalimbikitsa kuti odwala awo azikumana ndi prophylaxis komanso kuyeretsa thupi la lipids yoyipa. Zidole za cholesterol zimadziunjikira m'matumbo, ndipo zimatha kungobisa lumen ndi kukhala cholepheretsa kupitanso kwa magazi. Uwu ndi mkhalidwe wakufa womwe suyenera kuloledwa mulimonse.

Zizindikiro ndi mlingo

Mankhwala kuchokera kwa opanga Novartis sangatengedwe popanda chilimbikitso kuchokera kwa dokotala. Leskol Forte, yemwe ali ndi sodium ya fluvastatin, amawerengedwa ngati mankhwala amphamvu a cholesterol, chifukwa chake sayenera kugwiritsidwa ntchito pochiritsa ana osaposa zaka 9.

Odwala achikulire omwe ali ndi zaka zopitilira 18, Leskol Forte, yemwe chithunzi chake chimapezeka pang'ono, amalembera oyamba a hypercholesterolemia osakanikirana ndi dyslipidemia. Potere, mankhwalawa amayenera kutsatiridwa ndi zakudya zosankhidwa bwino. Pamavuto a cholesterol yayitali, nthawi zonse amalimbikitsidwa kuti muyang'anenso zakudya zanu. Iyi ndi njira ya theka yopambana.

Kwa odwala akuluakulu, mankhwalawa amaperekedwa kwa matenda a coronary atherosulinosis, ngati wodwala wapezeka ndi matenda amitsempha yamagazi. Leskol Forte amagwira ntchito yofunika kwambiri poletsa matenda osiyanasiyana omwe amakhudzana ndi mtima. Mwachitsanzo, akatswiri amatha kuvomereza mankhwalawa kwa anthu omwe ali pachiwopsezo cha opaleshoni ya mtima, omwe ali ndi myocardial infarction komanso kuthekera kwakukulu kwa kufa mwadzidzidzi chifukwa chomangidwa ndi mtima.

Leskol itha kugwiritsidwanso ntchito pochiza ana ndi achinyamata. Amagwiritsidwa ntchito pochiza heterozygous Famer hypercholesterolemia. Pankhaniyi, ndikofunikira kuphatikiza mankhwalawa ndi zakudya zosankhidwa bwino.

Kuchita bwino kwambiri kwa mankhwalawa kumatheka ndi milungu 4 yogwiritsira ntchito. Chifukwa chake, njira yotenga Leskol Forte idzakhala yayitali. Ponena za mlingo, umasankhidwa nthawi zonse payekha, kutengera zinthu zambiri zokhudzana. Mutha kumwa mankhwala nthawi ina iliyonse masana. Ndikofunikira kumwa kapisozi ndi madzi ambiri. Ngati mankhwalawa amagwiritsidwa ntchito pazolinga za prophylactic, mlingo ndi pafupipafupi wa oyang'anira zitha kuchepetsedwa.

Pambuyo pakugwiritsa ntchito Leskol kwa nthawi yayitali, mphamvu yake imakhalapo kwa nthawi yayitali. Nthawi zina, ngakhale pakakhala ana, chithandizo cha Leskol Forte chitha kupitilizidwa mpaka miyezi isanu ndi umodzi. Mankhwala ndi abwino kwa monotherapy. Koma ikhoza kuphatikizidwa ndi mankhwala ena.

Zizindikiro zogwiritsidwa ntchito

Main hypercholesterolemia (heterozygous achibale komanso osakhala amtundu, mtundu IIa, IIb komanso wosakanikirana malinga ndi gulu la Frederickson) - ndi mankhwala othandizira odwala omwe ali ndi chiopsezo chokhala ndi coronary atherosclerosis, kuphatikiza hypercholesterolemia ndi hypertriglyceridemia, kusagwirizana kwa thupi ndi kuchepa kwa thupi. Matenda a mtima wa Ischemic.

Contraindication ndi zoyipa

Mankhwalawa, akagwiritsidwa ntchito moyenera, amavomerezedwa ndi odwala. Komabe, musanayambe chithandizo, ndikofunikira kukaonana ndi dokotala, popeza Leskol Forte ali ndi zovuta zingapo zolakwika.

Choyamba, muyenera kuganizira kuti zomwe zimagwiritsidwa ntchito ndi mankhwalawa zimachotsedwa makamaka ndi chiwindi. Pansi pa 6% ya zinthu zonse zophatikizidwa ndi piritsi zimakonzedwa ndi impso. Chifukwa chake, kutsutsana kotheratu kogwiritsa ntchito makapisozi a Leskol ndi matenda a chiwindi omwe akugwira ntchito.

Kuphatikiza apo, akatswiri salimbikitsa kugwiritsa ntchito mankhwalawa panthawi yapakati komanso mkaka wa m`mawere. Kwa anthu omwe ali ndi hypersensitivity ku zigawo za Leskol Forte, analogues ya mankhwala amakulolani kusintha m'malo mwake ndi mankhwala ena omwe ali ndi vuto lofananalo.

Ponena za zoletsa zaka, ndikofunikira kuzindikira zaka za ana mpaka 9. Kafukufuku wasonyeza kuti anthu okalamba amalolera bwino mankhwalawa, kotero kwa odwala azaka zopitilira 65, kusintha kwa mankhwalawa ndi mtundu wa mankhwala sizofunikira.

Malangizowo akuwonetsa kuti odwala ambiri amalola bwino Leskol Forte. Komabe, nthawi zina, zovuta zina zimachitika poyesa mankhwala:

• mutu
• kusowa tulo
• kupweteka m'mimba
• kumva mseru
• zotupa pa thupi.

Kuchokera pamtima, ziwonetsero za vasculitis sizimachotsedwa. Zotsatira zoyipa zilizonse zimatheka pokhapokha ngati mugwiritsa ntchito molakwika mankhwalawo komanso kupitirira mlingo womwe dokotala walimbikitsa.

Leskol Forte ndi mankhwala ena

Popeza kuti chinthu chachikulu chomwe chimagwiritsa ntchito mankhwalawa ndi fluvastatin, chomwe sichimayenderana ndi zinthu zina, mankhwalawa amatha kuphatikizidwa ndi mankhwala onse. Komabe, mukamagwiritsa ntchito zina mwa izo, muyenera kuganiziranso zinthu zina.

Mwachitsanzo, ngati Leskol imatengedwa nthawi yomweyo ndi Rimfapicin, ndiye kuti izi zitha kuchepetsa kuchepa kwa zoyambira. Nthawi zina pamakhala kuchepa kwa bioavailability mpaka 50%. Zikakhala choncho, dokotala amatha kusintha mtundu wake kapena muyezo.

Mankhwala omwe amagwiritsidwa ntchito pochiza matenda am'mimba, monga Ranitidine ndi Omeprazole, angathe, kuwonjezera, kuyamwa kwa fluvastatin. Zotsatira zake, kugwiritsa ntchito mankhwalawa kumakulirakulira.

Pankhani ya contraindication pakugwiritsa ntchito Leskol Forte, ingathe m'malo mwa analogues. Awa atha kukhala Atoris, Torvakard, Rosart, Vasilip, Astin, Livazo, kapena ndalama zina zingapo zingapo zomwezo.

Momwe mungagwiritsire ntchito: Mlingo ndi njira ya chithandizo

Mkati, madzulo kapena pogona, osasamala chakudyacho. Makapiritsi / mapiritsi ayenera kumeza lonse ndi kapu yamadzi. Asanayambe chithandizo, wodwalayo ayenera kusinthidwa kukhala mokhazikika mu zakudya za hypocholesterol, zomwe ziyenera kuchitika pakumwa.

Mlingo woyambirira ndi 20-40 mg kapena 80 mg kamodzi patsiku (Mlingo wa 40 ndi 80 mg ungatengedwe Mlingo 2 ndi 3, motsatana). Mu matenda ofatsa, mlingo wa 20 mg / tsiku ukhoza kukhala wokwanira.

Mlingo woyambirira uyenera kusankhidwa payekhapayekha, poganizira kuchuluka kwa mafuta a cholesterol / LDL ndi cholinga chamankhwala.

Kusintha kwa mankhwalawa kwa mankhwalawa kumachitika molingana ndi mphamvu yomwe idachitika, pakapita milungu inayi.

Zotsatira za pharmacological

Synthetic hypolipidemic wothandizira, ali ndi hypocholesterolemic. Ndi mpikisano wopikisana wa HMG-CoA reductase, yemwe amasintha HMG-CoA kukhala mevalonate - chotsogolera kwa sterols, makamaka cholesterol. Fluvastatin imagwira ntchito yake yayikulu m'chiwindi, ndi mtundu wa 2 erythroenantiomers, umodzi womwe umagwira ntchito ya pharmacological. Kuponderezedwa kwa kaphatikizidwe ka cholesterol kumachepetsa kukhazikika kwake m'maselo a chiwindi, komwe kumalimbikitsa mapangidwe a LDL receptors ndipo potero amawonjezera kuchuluka kwa kuzungulira kwa ma cell a LDL ndi hepatocytes. Zotsatira zakutha kwake ndikuchepa kwa plasma ya cholesterol yathunthu, LDL cholesterol, apolipoprotein B ndi TG, komanso kuwonjezeka kwa cholesterol ya HDL. Zilibe mutagenic.

Zotsatira zake zimadziwika pambuyo pa masabata awiri, zimafika pakali pakatha milungu inayi kuyambira pachiyambire chithandizo ndikupitilira nthawi yonse ya zamankhwala.

Kugwiritsa ntchito ngati mankhwala monotherapy.

Odwala omwe ali ndi matenda a mtima a concitary hypercholesterolemia (LDL-C 115-190 mg / dl), kugwiritsa ntchito fluvastatin pa mlingo wa 40 mg / tsiku kwa zaka 2,5 kumachepetsa kupitilira kwa coronary atherosulinosis.

Pakalipano, palibe deta yogwiritsidwa ntchito kwa fluvastatin odwala omwe ali ndi homozygous Famer hypercholesterolemia.

Zotsatira zoyipa

Pafupipafupi mwadzidzidzi zotsatira zoyipa: zimachitika kawirikawiri - zopitilira 10%, kawirikawiri - 1-10%, kawirikawiri - kuchokera ku 0.001-1%, kawirikawiri kwambiri - ochepera 0.001%.

Kuchokera pamatumbo am'mimba: nthawi zambiri - dyspepsia, nseru, m'mimba ululu, kawirikawiri - hepatitis.

Kuchokera kwamanjenje: Nthawi zambiri - kupweteka mutu, kusowa tulo, pafupipafupi - paresthesia, hypesthesia, dysesthesia.

Thupi lawo siligwirizana: kawirikawiri - zidzolo, urticaria, kawirikawiri - eczema, dermatitis, oxant exanthema, angioedema, lupus-like syndrome.

Kuchokera ku ziwalo za hemopoietic: kawirikawiri - thrombocytopenia.

Kuchokera ku CCC: vasculitis.

Kuchokera ku minculoskeletal system: kawirikawiri - myalgia, kufooka kwa minofu, myopathy, kawirikawiri - myositis, rhabdomyolysis.

Zizindikiro zasayansi: kuchuluka kwa ma "chiwindi" transaminases katatu kapena kuposerapo (1-2%), CPK nthawi zoposa 5 (0.3-1%).

Malangizo apadera

Musanayambe chithandizo komanso nthawi yamankhwala, ndikulimbikitsidwa kuchita mayeso a "chiwindi" ogwira ntchito. Ngati zochita za AST kapena ALT ndizokwera katatu kuchulukirapo kuposa VGN ndikukhalabe okhazikika munthaka iyi, chithandizo chikuyenera kutha.

Odwala omwe atenga HMG-CoA reductase inhibitors, milandu ya myopathy yakhala ikufotokozedwa, kuphatikizapo myositis ndi rhabdomyolysis. Myopathy imatha kuganiziridwa kwa odwala omwe sakudziwika bwino amatulutsa myalgia, kupweteka kwa minofu kapena kufooka komanso kuwonjezeka kwakukulu mu ndende ya CK, kupitirira malire apamwamba a chizolowezi koposa nthawi 10. Odwala ayenera kulangizidwa kuti afotokoze nthawi iliyonse ululu wamisempha, kufooka kapena kufooka kwa minofu, makamaka ngati limodzi ndi malaise kapena kutentha thupi. Ndi kuwonjezeka kodziwika mu ndende ya CPK, matenda a myopathy kapena akuganiza kuti myopathy, chithandizo ndi fluvastatin ziyenera kuyimitsidwa nthawi yomweyo.

Pakalipano, palibe deta yogwiritsidwa ntchito kwa fluvastatin odwala omwe ali ndi homozygous Famer hypercholesterolemia.

Odwala ndi mkhutu aimpso ntchito iliyonse zovuta ndi okalamba palibe kufunika kuchita mlingo kusintha. Palibe chochitika chokhudzana ndi kugwiritsa ntchito fluvastatin mwa anthu ochepera zaka 18; sizingavomerezedwe pochiza odwala a gululi.

Kuyesa makoswe ndi akalulu sikunawonetse mphamvu ya teratogenic mu fluvastatin. Popeza HMG-CoA reductase inhibitors imachepetsa kapangidwe ka cholesterol ndipo, mwina, zinthu zina zogwirizana ndi chilengedwe - zotuluka za cholesterol, zimatha kuvulaza mwana wosabadwayo pamene mankhwalawa amalembera azimayi apakati (ngati pakati pamachitika mankhwala ndi gulu la mankhwala, chithandizo chikuyenera kutha) . Tiyenera kukumbukira kuti amayi akamagwiritsa ntchito lovastatin (HMG-CoA reductase inhibitor) yokhala ndi dextroamphetamine mu trimester yoyamba ya kubereka, kubadwa kwa ana omwe ali ndi mafupa osakanikira, tracheo-esophageal fistula, ndi anus atresia amadziwika.

Maphunziro owongoleredwa bwino okhudza kugwiritsa ntchito ana samakhalapo.

Poyeserera nyama, zotsatira zamafuta am'mimba pamimba ndi chithokomiro cha chithokomiro zidawululidwa.

Tiyenera kukumbukira kuti munthawi yomweyo makonda a lovastatin (choletsa HMG-CoA reductase) ndi cyclosporine, mankhwala antifungal, fibrate (kuphatikizapo gemfibrozil), kuchuluka kwa nicotinic acid, immunosuppressants, macrolides kumawonjezera chiopsezo cha kulephera kwa rhabdomyolysis ndi reute pachimake. ngakhale zochitika zazikulu za pharmacodynamic mogwirizana ndi mgwirizano wa fluvastatin ndi mankhwalawa sizinanenedwe.

Kuchita

Panalibe kusiyana kwakukulu mu mphamvu ya hypolipidemic ya fluvastatin pamene adayikidwa pakudya kwamadzulo kapena maola 4 pambuyo pake. Fluvastatin simalumikizana ndi madzi a mphesa (komanso mankhwala omwe ali gawo lapansi la CYP3A4 isoenzyme).

Colestyramine ndi colestipol amachepetsa bioavailability. Pofuna kupewa kuchepa kwa mayamwidwe a fluvastatin, sayenera kufotokozedwa osapitirira maola 4 mutatha kutenga bile acid sequers (mwachitsanzo, colestyramine).

Ndi munthawi yomweyo makonzedwe a fluvastatin ndi bezafibrate, gemfibrozil, ciprofibrate kapena nicotinic acid, palibe kusintha kwakukulu pamankhwala amodzi a bioavailability awa.

Kukhazikitsidwa munthawi yomweyo ndi CYP3A4 cytochrome isoenzyme inhibitors (itraconazole ndi erythromycin) kumakhala kovuta kwambiri pa bioavailability wa fluvastatin (popeza CYP3A4 sichita mbali yayikulu mu fluvastatin metabolism, titha kuyembekezera kuti enhibitors ena a lenenzazole, zotsatira zake pa kinetics).

Cimetidine, ranitidine, kapena omeprazole pang'onopang'ono zimachulukitsa bioavailability wa fluvastatin.

Rifampicin amachepetsa bioavailability wa fluvastatin ndi pafupifupi 50% (pakadali pano palibe umboni wotsimikizika wachipatala wosintha mu zochitika za fluvastatin akaperekedwa kwa odwala omwe amalandila chithandizo chazitali ndi rifampicin, komabe, kusintha koyenera kwa mlingo kungafunike kuti mukwaniritse zomwe mukufuna).

Momwe amachepetsa kwambiri Cmax ya rifampicin ndi 59%, AUC - mwa 51%, imawonjezera chilolezo cha plasma ndi 95%.

Odwala omwe analandira okhazikika Mlingo wa cyclosporine, panalibe kwambiri kuwonjezeka kwa bioavailability wa fluvastatin zotchulidwa tsiku lililonse mpaka 40 mg. Fluvastatin, sizikhudzanso kuchuluka kwa cyclosporine m'magazi.

Zosintha mu pharmacokinetics za phenytoin ndi munthawi yomweyo makonzedwe a fluvastatin ndi ochepa komanso amakomoka, mukamagwiritsa ntchito kuphatikiza, plasma mozama phenytoin imayang'aniridwa, ndipo mlingo wa fluvastatin suyenera kusinthidwa.

Odwala omwe ali ndi matenda a shuga a mtundu wachiwiri amalandiridwa ndi sulfonylurea derivatives (glibenclamide, tolbutamide), kujowina mankhwala a fluvastatin sikuti kumabweretsa kusintha kwakukuru m'magazi a shuga.

Zitha kuyambitsa kuchuluka kwa digoxin, komabe, pogwiritsa ntchito munthawi yomweyo, palibe zovuta zamankhwala zokhudzana ndi propranolol, digoxin, kapena losartan zomwe zinaonedwa.

Kuphatikiza ndi warfarin ndi zotumphukira zina za coumarin, chiopsezo chotulutsa magazi ndi / kapena nthawi ya prothrombin imachulukitsa (tikulimbikitsidwa kuti muzilamulira nthawi ya prothrombin koyambirira kwa kayendetsedwe ka fluvastatin, pamene mlingo umasinthidwa kapena utatha.

Mafunso, mayankho, ndemanga pa mankhwala a Leskol forte

Zomwe zimaperekedwa zimakonzekera akatswiri azamankhwala komanso zamankhwala. Chidziwitso chokwanira chokhudza mankhwalawa chili m'malangizo omwe amaphatikizidwa ndi zomwe amapanga ndi wopanga. Palibe chidziwitso chomwe chatumizidwa patsamba lino kapena tsamba lililonse la tsamba lathu chomwe chingagwire ntchito ngati cholowa m'malo mwapadera kwa katswiri.

Kupanga ndi mawonekedwe a kumasulidwa

Mu chikhazikitso cha ma PC 7 kapena 14, mu paketi ya makatoni 1 kapena 2 matuza (ma 14 ma PC) kapena matuza 4 (ma 7 ma PC.).

Nambala zotsatirazi zili ndi nambala za ATC zomwezo. Ma Analogs amasankhidwa malinga ndi kapangidwe kazomwe amapangira mankhwalawo ndipo ndizoyenera kwambiri. Zomwe zimapangidwira, zikuwonetsa kugwiritsa ntchito, Mlingo wa zinthu zomwe zimagwira zimasiyana.

12 imapereka ndikuyambira pa 2,678. 00 mpaka 3,401. 00 rub

Mlingo ndi makonzedwe

Mkati, ngakhale chakudya, kumeza lonse, ndi kapu yamadzi, 1 nthawi patsiku. Popeza fluvastatin simalumikizana ndi zinthu zomwe zili gawo lapansi la CYP3A4 isoenzyme, kuyanjana kwake ndi madzi a mphesa sikuyembekezeredwa.

Panalibe kuchepetsedwa kwa Hypolipidemic zotsatira za fluvastatin pamene adalembedwa pakati kapena maola 4 mutatha kudya chakudya chamadzulo.

Popeza mphamvu yayikulu ya hypolipidemic imayamba ndi sabata la 4, kuwunika koyamba kwa mankhwalawa kumachitika molingana ndi zomwe zimachitika, pakadutsa masabata anayi. The achire zotsatira za mankhwala Leskol ® Forte amakhwimitsidwa ndi ntchito kwa nthawi yayitali.

Asanayambe chithandizo ndi Leskol® Forte, wodwalayo ayenera kusamutsidwira ku zakudya za hypocholesterol zovomerezeka. Zakudya ziyenera kuchitika nthawi yonse ya chithandizo.

Mlingo woyambitsidwa woyamba ndi 80 mg (piritsi 1. Leskol® Forte 80 mg) kamodzi patsiku. Mu matenda ofatsa, mlingo wa 20 mg fluvastatin ukhoza kukhala wokwanira (1 ziphuphu. Leskol® 20 mg).

Kwa odwala omwe ali ndi vuto la mtima pambuyo pa opaleshoni ya angioneoplastic, mlingo woyambirira ndi 80 mg / tsiku.

Mankhwala a Leskol® Forte ndi othandiza mukamagwiritsidwa ntchito ngati monotherapy. Pali umboni wothandiza ndi chitetezo cha fluvastatin akaphatikizidwa ndi nicotinic acid, colestyramine kapena fibrate.

Ana ndi achinyamata ochepera zaka 18

Ana ndi achinyamata opitirira zaka 9 zakubadwa pasanathe miyezi isanu ndi umodzi asanayambe chithandizo ndi Leskol ® Forte ndipo nthawi yonse ya chithandizo ayenera kutsatira zakudya zapamwamba za hypocholesterol.

Mlingo woyambirira woperekedwa ndi 80 mg (piritsi limodzi la Leskol® Forte 80 mg) nthawi imodzi patsiku. Mu matenda ofatsa, mlingo wa 20 mg fluvastatin ukhoza kukhala wokwanira (1 ziphuphu. Leskol® 20 mg).

Kugwiritsa ntchito fluvastatin nthawi yomweyo ndi nicotinic acid, colestyramine kapena ma fiber mu ana ndi achinyamata sanaphunzire.

Odwala ndi mkhutu aimpso ntchito. Popeza fluvastatin amachotsedwa makamaka ndi chiwindi ndipo ndi ochepera 6% ya mlingo womwe umalandiridwa umathiridwa mu mkodzo, mwa odwala omwe ali ndi vuto laimpso pazovuta zilizonse, palibe chifukwa chosinthira mankhwala.

Odwala omwe ali ndi vuto la chiwindi. Kugwiritsa ntchito mankhwala Leskol Forte akuphatikizidwa chifukwa cha matenda a chiwindi kapena kuwonjezereka kwa kuchuluka kwa ma seramu transaminases a etiology osadziwika.

Odwala okalamba. Kuchita bwino ndi kulolera bwino kwa fluvastatin kwawonetsedwa kwa odwala azaka zopitilira 65 ndi ochepera kuposa m'badwo uno. Mwa anthu azaka zopitilira 65, mayankho omwe adalandira mankhwalawo adatchulidwa, pomwe palibe chidziwitso chokwanira chololera. Chifukwa chake, palibe chifukwa chosinthira mlingo wa Leskol® Forte malinga ndi zaka.

Ma Analogs amafanana ndi nambala 4 ya ATC. Mankhwala okhala ndi mawonekedwe osiyana, koma atha kukhala ofanana pakuwonetsa ndi njira yogwiritsira ntchito.

68 imaperekedwa kuyambira pa 51. 00 mpaka 922. 00 rub

46 imapereka kuyambira pa 42. 00 mpaka 10,526. 00 rub

3 imapereka kuchokera pa 207. 00 mpaka 234. 00 rub

154 imapereka kuyambira 33. 00 mpaka 8.796. 00 rub

27 amapereka akuyamba pa 129. 00 mpaka 502. 00 rub

115 imapereka kuyambira pa 5. 00 mpaka 179,000. 00 rub

37 imapereka ndikuyambira pa 10. 00 mpaka 2.602. 00 rub

138 imapereka kuyambira 59. 00 mpaka 1,866. 00 rub

72 imapereka kuchokera pa 203. 00 mpaka 1,886. 00 rub

269 ​​imapereka kuyambira 16. 00 mpaka 7.642. 00 rub

4 imapereka kuyambira pa 104. 00 mpaka 785. 00 rub

14 imapereka kuyambira pa 6. 00 mpaka 602. 00 rub

32 ipereka kuyambira 7. 00 mpaka 1,089. 00 rub

9 imapereka kuchokera pa 89. 00 mpaka 2,614. 00 rub

5 imapereka kuyambira 253. 00 mpaka 377. 00 rub

123 imapereka kuyambira pa 45. 00 mpaka 17,780. 00 rub

70 zopereka kuyambira pa 437. 00 mpaka 1,790. 00 rub

113 limapereka kuyambira pa 14. 00 mpaka 2,901. 00 rub

113 amapereka akuyamba pa 19. 00 mpaka 3.398. 00 rub

46 imapereka kuyambira pa 324. 00 mpaka 1,407. 00 rub

66 imapereka kuchokera pa 7. 00 mpaka 1,660. 00 rub

Ma 7 amapereka pamtengo wa 51. 00 mpaka 556. 00 rub

12 imapereka kuyambira pa 468. 00 mpaka 2,492. 00 rub

17 imapereka kuyambira pa 298. 00 mpaka 1.396. 00 rub

37 imapereka ndikuyambira pa 45. 00 mpaka 1,085. 00 rub

47 ipereka kuyambira pa 57. 00 mpaka 20,505. 00 rub

Lescol Forte: malangizo ndi fanizo la mankhwala

Ndi cholesterol yokwezeka, ndikofunikira kusankha njira yoyenera yamankhwala ndikuwayandikira molondola kusankha mankhwala. Mankhwala ayenera kukhala othandiza, otsika mtengo, okhala ndi zovuta zingapo.

Chimodzi mwazida zotchuka zomwe zimachepetsa lipids zowonjezera ndi Leskol Forte. Mutha kugula kuchipatala chilichonse, kupereka mankhwala a dokotala. Mankhwalawa ndi osayenera kudzipangira okha mankhwala, chifukwa ngati musankha mlingo woyenera komanso mankhwalawa amathandizanso kuvulaza thupi.

Musanagwiritse ntchito mankhwalawa, ndikofunikira kukaonana ndi dokotala yemwe adzakupatseni kuchuluka kwa mankhwalawo, ndikuyang'ana momwe wodwalayo alili ndi mbiri yachipatala. Mwambiri, a Lescol Forte ali ndi malingaliro abwino kuchokera kwa odwala ndi madokotala.

Chithandizo chogwira ntchito chomwe chawonetsedwa m'chithunzichi ndi fluvastatin. Ichi ndi mankhwala otsitsa lipid, omwe ndi amtundu wa HMG-CoAreductases ndipo akuphatikizidwa ndi gulu la ma statins. Kuphatikizikako kumaphatikizanso titanium dioxide, cellulose, potaziyamu hydrogen carbonate, okusayidi wachitsulo, magnesium stearate.

Mutha kugula mankhwala ku malo ogulitsira kapena apaderadera mukamapereka mankhwala. Mankhwala amapangidwa mwanjira ya mapiritsi a convex amtundu wachikasu, mtengo wawo ndi ma ruble 2600 ndi apamwamba.

Mfundo zoyenera kuchitira mankhwalawa ndi mapiritsi ndi kuletsa kuphatikiza cholesterol ndikuchepetsa kuchuluka kwake mu chiwindi. Zotsatira zake, kuchuluka kwa lipids zovulaza m'magazi a wodwala kumachepetsedwa.

1. Ngati mumatenga Leskol Forte pafupipafupi, kuchuluka kwa LDL kumatsitsidwa ndi 35 peresenti, cholesterol yonse - ndi 23 peresenti, ndi HDL ndi 10-15 peresenti.
2. Monga momwe awonera, odwala omwe ali ndi matenda a mtima omwe amatenga mapiritsi zaka ziwiri, kusanthula kwa coronary atherosulinosis kunawonedwa.
3. Odwala nthawi ya chithandizo, chiopsezo chotenga matenda amtima wamtima, kuchepa kwamitsempha, kapena sitiroko kumachepetsedwa kwambiri.
4. Zotsatira zofananazo zimawonedwa mwa ana omwe amathandizidwa ndi mapiritsi.

Kuti mudziwe zambiri za Leskol Fort, muyenera kuwerengera momwe mungagwiritsire ntchito mankhwalawa. Mankhwalawa amatengedwa kamodzi patsiku nthawi iliyonse, mosasamala chakudyacho. Piritsi imamezedwa yonse ndikutsukidwa ndi madzi ambiri.

Zotsatira za momwe mankhwalawa amawonedwera palibe pambuyo pa milungu inayi pambuyo pake, pomwe zotsatira za mankhwalawa zikupitilira kwa nthawi yayitali.

Asanayambe chithandizo, wodwalayo ayenera kutsatira zakudya zapamwamba za hypocholesterol, zomwe zimapitilira maphunziro onse.

Mlingo amasankhidwa ndi dokotala, poganizira zomwe zimachitika mthupi ndi zizindikiro za lipids zovulaza.

Pamaso pa matenda a mtima pambuyo pa opaleshoni, piritsi limodzi patsiku limagwiritsidwanso ntchito.

• Mankhwala a LescolForte akulimbikitsidwa kuti asaphatikizidwe ndi mankhwala ena mgululi. Pakadali pano, michere yambiri, nicotinic acid ndi cholestyramine amaloledwa kutengera mlingo.
• Ana ndi achinyamata opitirira zaka zisanu ndi zinayi amatha kuthandizidwa ndi mapiritsi ofanana ndi achikulire, koma izi zisanachitike, ndikofunikira kudya moyenera komanso zakudya zamankhwala kwa miyezi isanu ndi umodzi.
• Popeza mankhwalawa amachotsedwa makamaka ndi kutenga chiwindi, odwala omwe ali ndi vuto laimpso sangathe kusintha mlingo.
• Kumwa mankhwalawa ndikolakwika ngati pali matenda a impso, kuwonjezereka kwa kuchuluka kwa ma seramu transaminases osachokera komwe.

Malinga ndi kafukufuku, mapiritsi ndi makapisozi ndi othandiza pamtundu uliwonse. Izi zikuwonekeranso ndemanga zingapo zabwino. Koma muyenera kuganizira kuti mankhwalawa ali ndi zovuta zambiri zomwe muyenera kudziwa pasadakhale.

Sungani mankhwala pamtunda wosaposa 25 digiri, kutali ndi dzuwa ndi ana. Alumali moyo wa mapiritsi ndi zaka ziwiri.

Leskol Forte amagwiritsidwa ntchito pochita hypercholesterolemia, dyslipidemia, atherosclerosis, komanso kupewa matenda a mtima. Kwa ana osaposa zaka 9, chithandizo chamankhwala chimasonyezedwa pamaso pa chibadwa cha cholowa chamadzimadzi.

Tengani kuti mankhwala ali contraindicated ngati pali matenda a chiwindi ndi impso, sayanjana zimachitika yogwira mankhwala ndi zigawo zikuluzikulu za mankhwala. Simungathe kuchitira chithandizo panthawi yoyembekezera komanso yoyamwitsa.

Palibe milandu ya bongo yomwe yapezeka panthawiyi. Komabe, mapiritsi amatha kukhala ndi mitundu yosiyanasiyana yazotsatira zoyipa:

1. Vasculitis nthawi zina,
2. Supombocytopenia
3. Mutu, parasthesia, hypesthesia, zovuta zina zamanjenje,
4. Hepatitis mwapadera, matenda a dyspeptic,
5. Matenda azitsamba
6. Myalgia, myopathy, rhabdomyolysis,
7. Kuwonjezeka kasanu mu creatine phosphokinase, kuwonjezeka katatu kwa transmiasis.

Chisamaliro makamaka chiyenera kutengedwa ndi anthu omwe amamwa mowa kwambiri, komanso odwala matenda a chiwindi. Kuphatikiza sikofunikira kuchita mankhwalawa a rhabdomyolysis, matenda amisempha yayitali, chizindikiritso cha milandu yoyipa ya thupi kuma statins.

Musanayambe kumwa mankhwala, muyenera kuwunika momwe chiwindi chilili. Pakatha milungu iwiri, kuyezetsa magazi kumaperekedwa.

Ngati ntchito ya AST ndi ALT imachulukanso kuposa katatu, muyenera kukana kumwa mankhwalawo.

Wodwala akakhala ndi matenda a chithokomiro, kuwonongeka kwa chiwindi ndi impso, uchidakwa, kuwunikira kowonjezera kumachitika kuti usinthe kuchuluka kwa CPK.

Popeza kuti yogwira mankhwala fluvastatin sichikhudzana ndi mankhwala ena, imatha kutengedwa molumikizana ndi mapiritsi ena. Koma mukamagwiritsa ntchito mankhwala ena, muyenera kuyang'anira zina zake.

Makamaka, kutenga Rimfapicin nthawi yomweyo, Leskol Forte amachepetsa mphamvu pa thupi.

Komanso, nthawi zina bioavailability imatsitsidwa ndi 50 peresenti, pamenepa, adokotala amasintha mlingo wosankhidwa kapena kusankha mtundu wina wa mankhwala.

Pa mankhwala a Omeprazole ndi Ranitidine, omwe amagwiritsidwa ntchito pakusokoneza m'mimba, m'malo mwake, kuyamwa kwa fluvastatin kumawonjezereka, komwe kumawonjezera mphamvu yamapiritsi.

Mankhwala Leskol Forte ali ndi ma fanizo ambiri, pakadali pano pali mapiritsi oposa 70, omwe amagwira ntchito omwe ndi fluvastatin.

Otsika kwambiri ndi Astin, Atorvastatin-Teva ndi Vasilip, mtengo wawo ndi ma ruble 220-750. Komanso mu pharmacy mungapeze ma statins Atoris, Torvakard, Livazo, ali ndi mtengo wofanana ndi ma ruble 1,500.

Mankhwala okwera mtengo kwambiri akuphatikiza Krestor, Rosart, Liprimar, mapiritsi oterowo adzafunika ruble 2000-3000.

Mitunda yolimba kwambiri imaphatikizapo Rosuvastatin ndi Atorvastatin, Lovastatin, Simvastatin, Fluvastatin, Pravastatin amakhala olimba.

Mankhwalawa onse amatha kuchita chimodzimodzi, koma thupi la munthu limayankha nthawi zonse ku mtundu wina. Chifukwa chake, madokotala nthawi zambiri amalimbikitsa kuyesa ma statin ochepa ndikusankha yomwe ili yothandiza kwambiri.

Pakadali pano, pali mibadwo inayi yamankhwala a cholesterol yapamwamba.

• Mankhwala a m'badwo woyamba akuphatikizapo Simgal, Zovotin, Lipostat, Cardiostatin, Rovacor. Mapiritsi oterewa ali ndi lipid-yotsitsa, ndiye kuti, amachepetsa kaphatikizidwe ka lipids zovulaza ndikuletsa kudziunjikira kwawo m'mitsempha yamagazi. Kuchuluka kwa triglycerides kumacheperanso ndipo kuchuluka kwa cholesterol yopindulitsa kumakwera. Mankhwala amagwiritsidwa ntchito pochiza matenda a coronary atherosulinosis.
• Leskol Forte ndi am'badwo wa 2nd statins, amathandizira kupanga ma lipoproteins apamwamba kwambiri, omwe pamapeto pake amatsitsa kuchepa kwa kuchuluka kwa lipids ndi triglycerides. Mankhwalawa nthawi zambiri amaperekedwa kwa hypercholesterolemia, ndipo amathanso kuwalimbikitsa ngati prophylactic pa matenda a mtima.
• Mankhwala a m'badwo wachitatu amagwiritsidwa ntchito ngati chithandizo chamankhwala othandizira komanso masewera olimbitsa thupi sichithandiza. Awa ndi Liprimar, Tulip, Anvistat, Lipobay, Torvakard, Atomaks, Atorvaks. Kuphatikiza pa mankhwalawa kumawerengedwa kuti ndi njira yabwino yopeweretsera matenda a mtima, matenda a shuga, matenda a mtima. Zotsatira zamankhwala zimatha kuwonedwa pakatha milungu iwiri.
• Zothandiza kwambiri komanso zosavulaza thupi ndizomwe zili za m'badwo wachinayi. Amakhala ndi zochepa zotsutsana ndi zoyipa, chifukwa chake mapiritsi amatha kugwiritsidwa ntchito kuphatikiza ana. Pankhaniyi, mulingo wocheperako ndi wocheperako, ndipo zotsatira zake zitha kuwoneka m'masiku ochepa. Izi zikuphatikiza mankhwala monga Acorta, Tevastor, Roxer, Krestor, Mertenir, Livazo.

Dokotala wokhazikika ndi amene angadziwe kuti ndi mapiritsi ati omwe muyenera kugwiritsa ntchito mutatha kuphunzira mbiri yachipatala ndi zotsatira za matenda.

Kuti chithandizo chithandizike, ma statin amayenera kumwedwa nthawi zonse.

Koma ndikofunikira kuwunika momwe wodwalayo alili tsiku lililonse kuti ateteze zotsatira zoyipa, chifukwa mankhwala omwe ali mgululi ali ndi zovuta zambiri.

Statins akufotokozedwa mu kanema munkhaniyi.

Sonyezani shuga lanu kapena sankhani jenda pamayendedwe Kusaka OsapezekaKusaka Kuyang'ana kosapezeka

Kutentha kopitilira 25 ° C.

Pewani kufikira ana.

Osagwiritsa ntchito tsiku lotha ntchito likusonyezedwa pa phukusi.

Leskol Forte: tsatanetsatane wa mankhwalawa

Musanaganize zomwe malangizo a Leskol Forte angagwiritse ntchito, tisonkhanitsani zambiri zantchitoyo. Dzina lapadziko lonse la mankhwala ndi fluvastatin.

Mothandizidwa ndi gulu, mankhwalawo ndi amgulu la mankhwala ochepetsa lipid, subcategory - HMG-CoA reductase inhibitors. Mphamvu yogwira ya mankhwala ndi fluvastatin - wopanga yemwe ali m'gulu la ma statins.

Mankhwalawa amapezeka mu mawonekedwe a piritsi, mawonekedwe - mapiritsi achikasu a convex, mbali imodzi yomwe amalembedwa LE, mbali inayo - NVR.

Mapiritsiwo ali ndi matuza - pamakhala matumba awiri, chilichonse chimakhala ndi miyala 14, mumakhala matuza anayi ndi mapiritsi 7 aliwonse.

Kuphatikiza pa chophatikizira chachikulu (fluvastatin sodium salt), mapiritsiwo amakhalanso ndi zinthu zina zothandiza - mapadi, titanium dioxide, iron oxide (yomwe imapatsa miyala mapiritsi achikasu), potaziyamu hydrogen carbonate ndi magnesium stearate.

Zotsatira zakugwiritsa ntchito Leskol Forte

Odwala omwe ali ndi dyslipidemia ndi hypercholesterolemia omwe adagwiritsa ntchito mankhwalawa kwa milungu 24 adawonetsa zotsatirazi: panali kuchepa kwa cholesterol ndi 23%, kuchuluka kwa LDL kutsika ndi 34%, ndipo kuchuluka kwa HDL kudakwera pafupifupi 10%.

Odwala omwe ali ndi cholesterol choyambirira cha HDL amatha kukwaniritsa kuchuluka kwa 13-14%.

Kugwiritsa ntchito bwino kwa mankhwalawo kumafika pazomwe zili kumapeto kwa sabata lachiwiri, mapiri ogwira ntchito amatha sabata zina ziwiri, ndipo kugwiritsa ntchito Leskol Forte kumapitilira nthawi yonseyi.

Kuphatikiza apo, kugwiritsa ntchito mankhwalawa pafupipafupi ndikodalirika kumayambitsa kuchepetsa kwakukulu kwa zochitika zamtima zilizonse, ngati zingayambitsenso, kugunda kwa mtima, kufunikira kwa kuthana ndi mitsempha.

Chifukwa cha fluvastatin omwe amapezeka mu mankhwalawa, mwayi wokhala ndi vuto la mtima kapena kumangidwa kwadzidzidzi kwamtima kumachepetsa ndi 31%.

Kugwiritsa ntchito mankhwalawa ndi ana kunawonetsanso zotsatira zabwino - zomwe LDL zili m'magazi zimatsika ndi 5%:

1. Pachipatala chachikulu kwambiri cha LDL (zoposa 4.9 mmol / lita),
2. Ndi kuchuluka kwambiri (kuyambira 4.1 mmol / lita) ndi kukhalapo kwa zinthu zingapo zowopsa za cholesterol yamagazi, mwachitsanzo, shuga, kusuta, kuthamanga kwa magazi, komanso kuwonetsa koyambirira kwa matenda a mtima.
3. Pa kuchuluka kwa osachepera 4.1 mmol / lita ndi kukhalapo kwa chilema chodziwika pamlingo wa jini.

Kulandila Leskol Forte kwa ana azaka 9 zakubadwa sikubweretsa vuto lililonse - palibe zovuta zoyipa monga kukula kwakukula ndi chitukuko, vuto la kutha msinkhu.

Dziwani kuti zotsatira zakufufuzazi pamwambapa sizingatengedwe ngati maziko a chithandizo cha ana osaposa zaka 9.

Pharmacokinetic zotsatira

Poganizira Leskol Forte, malangizo ogwiritsira ntchito ayenera kukhala ndi chidziwitso cha mankhwala a pharmacokinetics. Ganizirani zofunikira pankhaniyi.

Fluvastatin ali ndi mayamwidwe abwino. Kulowa kwamkati mwa mankhwalawa monga njira yothetsera vutoli kumachitika mwachangu komanso pafupifupi kutengeka kwathunthu - mtengo wake ndi 98%.

Ponena za Leskol Forte, njira yonyamulirayi imatenga nthawi yayitali 60% chifukwa cha mankhwalawa omwe amapezeka nthawi yayitali. Mankhwala othandizira ali m'magazi kwa maola anayi. Mankhwala omwe amwe atatha kudya ali ndi mayamwidwe ochepera. Chizindikiro cha bioavailability ndi 24%.

Kupenda

Njira zazikulu za metabolic zimachitika m'chiwindi. Zinthu zomwe zimalowa m'magazi ndi fluvastatin ndi wochepa wogwiritsa ntchito-metabolite - desisopropyl-propionic acid.

Njira yosinthira zinthu yogwira siyogwirizana ndi cytochrome P450, chifukwa chake kuchuluka kwa metabolic sikudalira zinthu zina zomwe zimagwira pa cytochrome 450. Fluvastatin palokha imalepheretsa CYP2C9 isoenzyme.

Mafuta amuchotsa mwachilengedwe - mpaka 95% amuchotseredwa ndowe komanso pafupifupi 5% - kudzera mkodzo. Chilolezo cha plasma mwa wodwala yemwe amamwa mankhwalawa ndi 1.8 l / m.

Milandu yapadera ya pharmacokinetics

Nthawi yakutenga Leskol Forte sikugwira ntchito yayikulu - kumwa mankhwalawa musanadye chakudya chamadzulo komanso maola 4 atatha osawonetsa kusintha kulikonse ku AUC.

Jenda komanso zaka za wodwalayo sizimathandizira kudziwa kuyamwa kwa zomwe zimachitika. Komabe, phindu la mankhwalawa limawonjezeka pang'ono mwa okalamba.

Chizindikiro chovomerezeka

Zizindikiro zogwiritsidwa ntchito ndi akulu ndi:

• Hypercholesterolemia ndi dyslipidemia, ngati chithandizo cha mankhwala,
• Hypercholesterolemia ndi atherosulinosis, kuphatikizapo osatchulidwa kwambiri
• Kupewa matenda a mtima.

Ana ndi achinyamata opitirira zaka 9 amatha kugwiritsa ntchito mankhwalawa ngati pali mtundu wina wa banja.

Mlingo woyenera

Leskol Forte amatengedwa kamodzi patsiku, mosasamala nthawi yakudya. Piritsi imatsukidwa ndi madzi. Kuchuluka kwa mankhwalawa kumafikira milungu inayi yokha ya kudya, chifukwa chake, kuwunika kwa mankhwalawa kungakhale pambuyo pa nthawi yomwe ili pamwambapa.

Dokotala asanakupatseni mankhwala, wodwala ayenera kudya zakudya zomwe zimapangidwira kutsitsa cholesterol. Iyenera kuonedwa nthawi zonse pamene wodwala akutenga Leskol Forte.

Mlingo woyambirira woperekedwa ndi 80 mg, ndipo ngati pali matenda ofatsa, ndikokwanira kutenga 20 mg. Mlingo umagwira ntchito kwa ana ndi akulu omwe.

Chithandizo chogwira ntchito cha mankhwala chimatha kulumikizana ndi nicotinic acid ndi ma fibrate (kutsimikizika kogwira ntchito).

Kuphatikiza apo, chidachi chitha kugwiritsidwa ntchito ngati odziimira pawokha ochizira.

Mndandanda wamankhwala ndi mitengo

Choyamba, tiyeni tilingalire za fanizo la Leskol Forte. Mankhwala onse omwe alembedwa pansipa, tawasankha malinga ndi dongosolo la gulu la ATC.

Zomwe zimagwiritsidwa ntchito ndi mankhwala ndi fluvastatin. Ma analogu onse osankhidwa amafanana ndi manambala a 4 a ATC, ngakhale atapangidwa, omwe amatha kusiyanasiyana ndi mankhwala ena, malinga ndi mawonekedwe ndi njira.

Pakadali pano, pali mitundu pafupifupi 70 pamsika - lingalirani ena a iwo:

• Atoris - kuyambira 195 mpaka 1200 rubles,
• Vasilip - kuchokera ku ruble 136 mpaka 785,
• Krestor - kuchokera 347 mpaka 19400 rubles,
• Liprimar - kuchokera ku ruble 200 mpaka 2800,
• Torvakard - kuyambira 237 mpaka 1500 rubles,
• Livazo - kuchokera 455 mpaka 1440 rubles,
• Rosart - kuyambira 370 mpaka 2400 rubles,
• Astin - kuchokera pa ma ruble 87 mpaka 220,
• Atorvastatin-Teva - kuchokera 93 mpaka 597 rubles.
• Mtengo wapakati wa Leskol Forte ndi ma ruble 2800.

Kodi mankhwalawa amagwira ntchito bwanji?

Chithandizo chogwira ntchito chomwe chawonetsedwa m'chithunzichi ndi fluvastatin. Ichi ndi mankhwala otsitsa lipid, omwe ndi amtundu wa HMG-CoAreductases ndipo akuphatikizidwa ndi gulu la ma statins. Kuphatikizikako kumaphatikizanso titanium dioxide, cellulose, potaziyamu hydrogen carbonate, okusayidi wachitsulo, magnesium stearate.

Mutha kugula mankhwala ku malo ogulitsira kapena apaderadera mukamapereka mankhwala. Mankhwala amapangidwa mwanjira ya mapiritsi a convex amtundu wachikasu, mtengo wawo ndi ma ruble 2600 ndi apamwamba.

Mfundo zoyenera kuchitira mankhwalawa ndi mapiritsi ndi kuletsa kuphatikiza cholesterol ndikuchepetsa kuchuluka kwake mu chiwindi. Zotsatira zake, kuchuluka kwa lipids zovulaza m'magazi a wodwala kumachepetsedwa.

1. Ngati mumatenga Leskol Forte pafupipafupi, kuchuluka kwa LDL kumatsitsidwa ndi 35 peresenti, cholesterol yonse - ndi 23 peresenti, ndi HDL ndi 10-15 peresenti.
2. Monga momwe awonera, odwala omwe ali ndi matenda a mtima omwe amatenga mapiritsi zaka ziwiri, kusanthula kwa coronary atherosulinosis kunawonedwa.
3. Odwala nthawi ya chithandizo, chiopsezo chotenga matenda amtima wamtima, kuchepa kwamitsempha, kapena sitiroko kumachepetsedwa kwambiri.
4. Zotsatira zofananazo zimawonedwa mwa ana omwe amathandizidwa ndi mapiritsi.

Malangizo ogwiritsira ntchito

Kuti mudziwe zambiri za Leskol Fort, muyenera kuwerengera momwe mungagwiritsire ntchito mankhwalawa. Mankhwalawa amatengedwa kamodzi patsiku nthawi iliyonse, mosasamala chakudyacho. Piritsi imamezedwa yonse ndikutsukidwa ndi madzi ambiri.

Zotsatira za momwe mankhwalawa amawonedwera palibe pambuyo pa milungu inayi pambuyo pake, pomwe zotsatira za mankhwalawa zikupitilira kwa nthawi yayitali.

Asanayambe chithandizo, wodwalayo ayenera kutsatira zakudya zapamwamba za hypocholesterol, zomwe zimapitilira maphunziro onse.

Poyamba, ndikulimbikitsidwa kuti mutenge piritsi limodzi la 80 mg. Ngati matendawa ndi ofatsa, ndikokwanira kugwiritsa ntchito 20 mg patsiku, momwe makapisozi amapezeka. Mlingo amasankhidwa ndi dokotala, poganizira zomwe zimachitika mthupi ndi zizindikiro za lipids zovulaza. Pamaso pa matenda a mtima pambuyo pa opaleshoni, piritsi limodzi patsiku limagwiritsidwanso ntchito.

• Mankhwala a LescolForte akulimbikitsidwa kuti asaphatikizidwe ndi mankhwala ena mgululi. Pakadali pano, michere yambiri, nicotinic acid ndi cholestyramine amaloledwa kutengera mlingo.
• Ana ndi achinyamata opitirira zaka zisanu ndi zinayi amatha kuthandizidwa ndi mapiritsi ofanana ndi achikulire, koma izi zisanachitike, ndikofunikira kudya moyenera komanso zakudya zamankhwala kwa miyezi isanu ndi umodzi.
• Popeza mankhwalawa amachotsedwa makamaka ndi kutenga chiwindi, odwala omwe ali ndi vuto laimpso sangathe kusintha mlingo.
• Kumwa mankhwalawa ndikolakwika ngati pali matenda a impso, kuwonjezereka kwa kuchuluka kwa ma seramu transaminases osachokera komwe.

Malinga ndi kafukufuku, mapiritsi ndi makapisozi ndi othandiza pamtundu uliwonse. Izi zikuwonekeranso ndemanga zingapo zabwino. Koma muyenera kuganizira kuti mankhwalawa ali ndi zovuta zambiri zomwe muyenera kudziwa pasadakhale.

Sungani mankhwala pamtunda wosaposa 25 digiri, kutali ndi dzuwa ndi ana. Alumali moyo wa mapiritsi ndi zaka ziwiri.

Yemwe akuwonetsedwa chithandizo

Leskol Forte amagwiritsidwa ntchito pochita hypercholesterolemia, dyslipidemia, atherosclerosis, komanso kupewa matenda a mtima. Kwa ana osaposa zaka 9, chithandizo chamankhwala chimasonyezedwa pamaso pa chibadwa cha cholowa chamadzimadzi.

Tengani kuti mankhwala ali contraindicated ngati pali matenda a chiwindi ndi impso, sayanjana zimachitika yogwira mankhwala ndi zigawo zikuluzikulu za mankhwala. Simungathe kuchitira chithandizo panthawi yoyembekezera komanso yoyamwitsa.

Palibe milandu ya bongo yomwe yapezeka panthawiyi. Komabe, mapiritsi amatha kukhala ndi mitundu yosiyanasiyana yazotsatira zoyipa:

1. Vasculitis nthawi zina,
2. Supombocytopenia
3. Mutu, parasthesia, hypesthesia, zovuta zina zamanjenje,
4. Hepatitis mwapadera, matenda a dyspeptic,
5. Matenda azitsamba
6. Myalgia, myopathy, rhabdomyolysis,
7. Kuwonjezeka kasanu mu creatine phosphokinase, kuwonjezeka katatu kwa transmiasis.

Chisamaliro makamaka chiyenera kutengedwa ndi anthu omwe amamwa mowa kwambiri, komanso odwala matenda a chiwindi. Kuphatikiza sikofunikira kuchita mankhwalawa a rhabdomyolysis, matenda amisempha yayitali, chizindikiritso cha milandu yoyipa ya thupi kuma statins.

Musanayambe kumwa mankhwala, muyenera kuwunika momwe chiwindi chilili. Pakatha milungu iwiri, kuyezetsa magazi kumaperekedwa. Ngati ntchito ya AST ndi ALT imachulukanso kuposa katatu, muyenera kukana kumwa mankhwalawo. Wodwala akakhala ndi matenda a chithokomiro, kuwonongeka kwa chiwindi ndi impso, uchidakwa, kuwunikira kowonjezera kumachitika kuti usinthe kuchuluka kwa CPK.

Popeza kuti yogwira mankhwala fluvastatin sichikhudzana ndi mankhwala ena, imatha kutengedwa molumikizana ndi mapiritsi ena. Koma mukamagwiritsa ntchito mankhwala ena, muyenera kuyang'anira zina zake.

Makamaka, kutenga Rimfapicin nthawi yomweyo, Leskol Forte amachepetsa mphamvu pa thupi.

Komanso, nthawi zina bioavailability imatsitsidwa ndi 50 peresenti, pamenepa, adokotala amasintha mlingo wosankhidwa kapena kusankha mtundu wina wa mankhwala.

Pa mankhwala a Omeprazole ndi Ranitidine, omwe amagwiritsidwa ntchito pakusokoneza m'mimba, m'malo mwake, kuyamwa kwa fluvastatin kumawonjezereka, komwe kumawonjezera mphamvu yamapiritsi.

Mitu ya mankhwalawa

Mankhwala Leskol Forte ali ndi ma fanizo ambiri, pakadali pano pali mapiritsi oposa 70, omwe amagwira ntchito omwe ndi fluvastatin.

Otsika kwambiri ndi Astin, Atorvastatin-Teva ndi Vasilip, mtengo wawo ndi ma ruble 220-750. Komanso mu pharmacy mungapeze ma statins Atoris, Torvakard, Livazo, ali ndi mtengo wofanana ndi ma ruble 1,500.

Mankhwala okwera mtengo kwambiri akuphatikiza Krestor, Rosart, Liprimar, mapiritsi oterowo adzafunika ruble 2000-3000.

Ndi mitundu yanji ya ma statins omwe alipo

Mitunda yolimba kwambiri imaphatikizapo Rosuvastatin ndi Atorvastatin, Lovastatin, Simvastatin, Fluvastatin, Pravastatin amakhala olimba.

Mankhwalawa onse amatha kuchita chimodzimodzi, koma thupi la munthu limayankha nthawi zonse ku mtundu wina. Chifukwa chake, madokotala nthawi zambiri amalimbikitsa kuyesa ma statin ochepa ndikusankha yomwe ili yothandiza kwambiri.

Mankhwala ena m'gululi amalumikizana ndi mankhwala ena. Chifukwa, mwachitsanzo, Atorvastatin, Pravastatin ndi Simvastatin sangagwiritsidwe ntchito mutatha kumwa madzi a mphesa, izi zitha kubweretsa zotsatira zowopsa. Chowonadi ndi chakuti madzi a citrus amalimbikitsa kuchuluka kwa ma statins m'magazi.

Pakadali pano, pali mibadwo inayi yamankhwala a cholesterol yapamwamba.

• Mankhwala a m'badwo woyamba akuphatikizapo Simgal, Zovotin, Lipostat, Cardiostatin, Rovacor. Mapiritsi oterewa ali ndi lipid-yotsitsa, ndiye kuti, amachepetsa kaphatikizidwe ka lipids zovulaza ndikuletsa kudziunjikira kwawo m'mitsempha yamagazi. Kuchuluka kwa triglycerides kumacheperanso ndipo kuchuluka kwa cholesterol yopindulitsa kumakwera. Mankhwala amagwiritsidwa ntchito pochiza matenda a coronary atherosulinosis.
• Leskol Forte ndi am'badwo wa 2nd statins, amathandizira kupanga ma lipoproteins apamwamba kwambiri, omwe pamapeto pake amatsitsa kuchepa kwa kuchuluka kwa lipids ndi triglycerides. Mankhwalawa nthawi zambiri amaperekedwa kwa hypercholesterolemia, ndipo amathanso kuwalimbikitsa ngati prophylactic pa matenda a mtima.
• Mankhwala a m'badwo wachitatu amagwiritsidwa ntchito ngati chithandizo chamankhwala othandizira komanso masewera olimbitsa thupi sichithandiza. Awa ndi Liprimar, Tulip, Anvistat, Lipobay, Torvakard, Atomaks, Atorvaks. Kuphatikiza pa mankhwalawa kumawerengedwa kuti ndi njira yabwino yopeweretsera matenda a mtima, matenda a shuga, matenda a mtima. Zotsatira zamankhwala zimatha kuwonedwa pakatha milungu iwiri.
• Zothandiza kwambiri komanso zosavulaza thupi ndizomwe zili za m'badwo wachinayi. Amakhala ndi zochepa zotsutsana ndi zoyipa, chifukwa chake mapiritsi amatha kugwiritsidwa ntchito kuphatikiza ana. Pankhaniyi, mulingo wocheperako ndi wocheperako, ndipo zotsatira zake zitha kuwoneka m'masiku ochepa. Izi zikuphatikiza mankhwala monga Acorta, Tevastor, Roxer, Krestor, Mertenir, Livazo.

Dokotala wokhazikika ndi amene angadziwe kuti ndi mapiritsi ati omwe muyenera kugwiritsa ntchito mutatha kuphunzira mbiri yachipatala ndi zotsatira za matenda. Kuti chithandizo chithandizike, ma statin amayenera kumwedwa nthawi zonse. Koma ndikofunikira kuwunika momwe wodwalayo alili tsiku lililonse kuti ateteze zotsatira zoyipa, chifukwa mankhwala omwe ali mgululi ali ndi zovuta zambiri.

Statins akufotokozedwa mu kanema munkhaniyi.