Momwe mungagwiritsire ntchito mankhwala Trulicity?

Anthu odwala matenda ashuga amafuna mankhwala osachiritsika kuti azisinthasintha shuga. Nthawi zambiri, mumayenera kumwa mankhwalawa nthawi imodzi, chifukwa imodzi singathe. Koma pali ndalama zomwe zimatha, ndi jakisoni imodzi pa sabata, kupereka zotsatira zomwe mukufuna. Chimodzi mwa izo ndi Trulicity. Lingalirani malangizo omwe amagwiritsidwa ntchito mwatsatanetsatane ndikuyerekeza ndi fanizo.

Kutulutsa mawonekedwe, kapangidwe kake ndi ma CD

Ndi njira yodziwikiratu, yopanda utoto kwa makina amtundu wanthawi zonse. Ma cholembera anayi a syringe okhala ndi kuchuluka kwa 0,5 ml amaikidwa pakatoni. The analemba mankhwala zikuphatikiza:

• kuseglutide - 0,75 mg kapena 1.5 mg,
• anhydrous citric acid - 0,07 mg,
• mannitol - 23.2 mg,
• polysorbate 80 (masamba) - 0,5 mg,
• sodium citrate dihydrate - 1,37 mg,
• madzi a jakisoni - mpaka 0,5 ml.

Zotsatira za pharmacological

Ili ndi vuto la hypoglycemic. Zinthu zomwe zimagwiritsidwa ntchito ndizotsutsana ndi glucagon-polypeptide receptors. Chifukwa cha mawonekedwe ake, ndioyenera kuyendetsedwera koyenda ndi pafupipafupi nthawi imodzi yokha pa sabata.

Mankhwala amakhazikika ndipo amasunga kuchuluka kwa shuga pamimba yopanda kanthu, musanadye komanso sabata lonse. Amachepetsa kuthira kwam'mimba. Amasintha kuwongolera kwa hypoglycemia mwa odwala omwe ali ndi matenda a shuga a 2. Zimatsimikiziridwa kuti gawo lomwe limagwira ntchito ndilothandiza kwambiri kuposa metformin, ndipo zotsatira zamankhwala zimathamanga.

Pharmacokinetics

Kuzindikira kwakukulu m'magazi kumachitika pambuyo pa maola 48. Amino acid cleavage imachitika kudzera mu mapuloteni a catabolism. Imafufutidwa pafupifupi masiku 4-7.

Amapangidwira zochizira matenda am'mimba a shuga 2, onse mu mawonekedwe a monotherapy, komanso kuphatikiza ena othandizira a hypoglycemic (kuphatikizapo insulin).

Contraindication

• Hypersensitivity pamagawo a mankhwala,
• mtundu 1 shuga
• matenda ashuga ketoacidosis,
• Matenda oopsa am'mimba,
• kuvulala kwambiri aimpso,
• pachimake kapamba
• khansa ya chithokomiro (banja kapena mbiri yakale),
• kulephera kwa mtima
• mimba
• kuyamwa
• wazaka zosakwana 18.

Gwiritsani ntchito mosamala pochiza odwala omwe amamwa mankhwala omwe amafunika kuti azichotse msanga m'mimba, komanso anthu azaka zopitilira 75.

Malangizo ogwiritsira ntchito (njira ndi Mlingo)

Mankhwalawa amangoperekedwa pang'onopang'ono, jakisoni wamkati ndi mu mnofu amaletsedwa. Mlingo umasankhidwa payekha ndi dokotala wopezekapo.

Zingwe zitha kuchitika mu ntchafu, phewa, m'mimba. Sizitengera kudya zakudya ndi nthawi ya tsiku, koma kuyang'anira nthawi yomweyo ndikofunikira. Ndi monotherapy, mlingo wa 0.75 mg kamodzi pa sabata umalimbikitsidwa, kuphatikiza ndi mankhwala ena, 1.5 mg. Mlingo woyambira wa okalamba ndi 0,75 mg.

Mfuti ikasowa, mankhwalawo amayenera kuperekedwa ngati maola opitilira 72 asiyidwa dongosolo lotsatira. Kupanda kutero, muyenera kudikirira tsiku lotsatira la jekeseni, kenako pitilizani chithandizo chomwechi.

Kusintha kwa Mlingo sikofunikira kwa odwala okalamba (zaka 75), komanso pamaso pa mbiri ya kuphwanya kwa impso kapena kwa chiwindi.

Zotsatira zoyipa

• Hypoglycemia,
• Kusanza ndi kusanza, kutsekula m'mimba,
• Reflux burping,
• Anachepetsa chilako
• Dyspepsia
• Kupweteka kwam'mimba
• Kukopa kwamaluwa ndi maluwa,
• Zotsatira zoyipa zamagetsi,
• Asthenia
• Tachycardia,
• Pancreatitis
• Thupi lawo siligwirizana pamalo jakisoni,
• Kulephera kwina (kawirikawiri kwambiri)
• Chotupa cha chithokomiro (chosowa kwambiri).

Kuyanjana kwa mankhwala osokoneza bongo

Mwina kuphwanya mayamwidwe amkamwa hypoglycemic mankhwala akumwa. Izi ziyenera kuganiziridwa popereka mankhwala.

Pazonse, kusintha kwa mankhwalawa kwa mankhwala ena omwe amagwiritsidwa ntchito sikufunikira - mphamvu zawo kwa wina ndi mzake ndizochepa ndipo sizimayambitsa zovuta.

Malangizo apadera

Dokotalayo ayenera kudziwa wodwala zoopsa zomwe zingachitike akachira ndi chida ichi, kuphatikizapo mwayi wokhala ndi khansa ya chithokomiro komanso zotupa zina.

Mankhwala amasiya ngati kapamba amamuganizira.

Kuti muchepetse chiopsezo cha hypoglycemia pogwiritsa ntchito Trulicity ndi insulin kapena sulfonylurea, tikulimbikitsidwa kuti muchepetse Mlingo wawo.

Kawirikawiri samalamulidwa kuchiza kwa anthu omwe ali ndi hepatic kapena a impso. Potere, kuyang'anira wodwala nthawi zonse ndikofunikira.

Trulicity sichilowa m'malo mwa insulin. Amayikidwa pokhapokha ngati ena othandizira a hypoglycemic sathandizira, kuphatikiza ndi zakudya komanso zolimbitsa thupi.

Mankhwalawo pawokha samakhudza kuyendetsa galimoto kapena makina ovuta. Kuphatikiza ndi insulin kapena sulfonylurea, pamakhala chiopsezo cha hypoglycemia, chifukwa chake kuyendetsa magalimoto kuyenera kukhala kochepa.

Osagwiritsidwa ntchito pochiza matenda ashuga a ketoacidosis.

Mankhwala amaperekedwa pokhapokha ngati amupatsa mankhwala.

Kutulutsa mawonekedwe ndi kapangidwe kake

Mankhwala amamasulidwa munjira ya yankho la subcutaneous (s / c) makuponi: madzi oyera, osapaka utoto (0.5 ml iliyonse mu syringe yotsekedwa mbali imodzi ndipo ali ndi singano ya jakisoni yokhala ndi kapu yoteteza - mbali inayo, pamakatoni a makatoni 4 syringe , mumtundu uliwonse womwe syringe imodzi imapangidwira, ndi malangizo ogwiritsira ntchito Trulicity).

0,5 ml ya yankho lili:

• yogwira mankhwala :helangglutide - 0,75 kapena 1.5 mg,
• zina zowonjezera: mannitol, sodium citrate dihydrate, polysorbate 80 (masamba), anhydrous citric acid, madzi a jekeseni.

Mankhwala

Dulaglutide ndi glucagon wokhala ngati peptide 1 (GLP-1) wa receptor agonist. Molekyulu ya thunthu imakhala ndi maunyolo awiri ofanana omwe amalumikizidwa ndi ma disulfide, omwe aliwonse omwe amaphatikizidwa ndi cholumikizira cha munthu chosinthika cha GLP-1 cholumikizidwa bwino kudzera ndi tinthu tating'onoting'ono ta polypeptide ndi chidutswa chachikulu cha unyolo (Fc) wa immunogulinulin G4 (IgG4) yamunthu. Gawo la molekyuli ya molegule, yomwe ndi analogue ya GLP-1, pafupifupi 90% yofanana ndi yachilengedwe (yachilengedwe) yamunthu GLP-1. Hafu ya moyo (T_1/2) wa wobadwa wa munthu GLP-1 chifukwa chobanika ndi dipeptidyl peptidase-4 (DPP-4) komanso chilolezo cha impso ndi mphindi 1.5-2.

Dulaglutide, mosiyana ndi mbadwa ya GLP-1, imagonjetsedwa ndi DPP-4 ndipo ndi yayikulu kukula, yomwe imathandiza kuchepetsa kuyamwa ndikuchepetsa chilolezo cha impso. Zomwe zimapangidwira monga momwe zimagwirira ntchito zimapereka mawonekedwe osungunuka, ndi T_1/2 chifukwa cha izi, limafika masiku 4.7, omwe amakupatsani mwayi kulowa Trulicity s / c 1 nthawi imodzi pa sabata. Kuphatikiza apo, kupanga kwa molekyulu ya molegule imapangitsa kuchepa kwa kuyankha kwakuthupi komwe kumayang'aniridwa ndi Fcγ receptor ndikuchepetsa mphamvu ya immunogenic.

Hypoglycemic zochita za chinthu zimagwirizidwa ndi njira zingapo zochitira GLP-1. Poyerekeza ndi kuzika kwa kuchuluka kwa glucose, kundglutide mu pancreatic β-cell kumabweretsa kuwonjezeka kwa kuchuluka kwa intcacellular cyclic adenosine monophosphate (cAMP), komwe kumapangitsa kuchuluka kwa insulin. Mtundu wachiwiri wa matenda a shuga a mellitus (osadalira insulin), mankhwalawo amalepheretsa kuchuluka kwa glucagon, komwe kumapangitsa kutsika kwa kutulutsa shuga m'magazi, komanso kumachepetsa kuthira kwam'mimba.

Kuyambira kuyambira kwa oyamba kutsata, omwe ali ndi mtundu wachiwiri wa matenda a shuga, Trulicity imathandizira kuwongolera glycemic pochepetsa mwachangu glucose, musanadye komanso mutatha kudya, komwe kumatenga sabata mpaka mlingo wotsatira.

Odwala omwe ali ndi mtundu wachiwiri wa matenda a shuga, molingana ndi zotsatira za kafukufuku wa mankhwala; Komanso, panthawi yowerengera, zidapezeka kuti ndi mlingo umodzi wa 1.5 mg, kuchuluka kwambiri kwa insulin komwe kumachitika ndi ma pancreatic β-cell ndipo ntchito ya β-cell idayendetsedwa mwa odwala omwe ali ndi shuga omwe amadalira insulin, poyerekeza ndi gulu la placebo.

Mbiri ya pharmacokinetic ndi yogwirizana ndi pharmacodynamic pazomwe zimagwira zimathandiza kugwiritsa ntchito Trulicity kamodzi pa sabata.

Mphamvu ndi chitetezo cha lulaglutide zidawerengedwa m'mayesero 6 omwe ankayang'anira gawo limodzi la III, lomwe limakhudza odwala 5171 omwe ali ndi mtundu wa 2 matenda a shuga (kuphatikiza 958 azaka zapakati pa 65 ndi 93 zopitilira 75). Maphunzirowa anali okhudza anthu 3,136 omwe amathandizidwa ndi lulaglutide, pomwe 1,719 a iwo amalandila mankhwalawo kamodzi pa sabata pa 1.5 mg ndi 1417 pa mlingo wa 0.75 mg wokhala ndi pafupipafupi kugwiritsa ntchito. Kafukufuku onse adawonetsa kusintha kwakukulu pakulamulira kwa glycemic, monga momwe anayeza ndi glycated hemoglobin (HbA1C).

Kugwiritsa ntchito kulaglutide ngati mankhwala a monotherapy poyerekeza ndi metformin kunaphunziridwa pamayeso azachipatala a milungu 52 mothandizidwa nawo. Ndi makonzedwe a Trulicity kamodzi pa sabata pa Mlingo wa 1.5 mg / 0.75 mg, mphamvu yake idaposa ya metformin, yogwiritsidwa ntchito tsiku lililonse 1500-2000 mg, pokhudzana ndi kuchepetsa kwa HbA1c. Masabata 26 atangoyambira kumene chithandizo, ambiri ophunzirawo adakwaniritsa chandamale HbA1c

Kutulutsa mafomu ndi kapangidwe kake

Njira yotheka popanda kupaka utoto. 1 cm³ imakhala ndi 1.5 mg kapena 0,75 mg wa phulaglutida pawiri. Cholembera chovomerezeka chimakhala ndi 0,5 ml ya yankho. Singano ya hypodermic imaperekedwa ndi syringe. Pali ma syringes anayi phukusi limodzi.

Cholembera chovomerezeka chimakhala ndi 0,5 ml ya yankho.

Zizindikiro zogwiritsidwa ntchito

• ndi monotherapy (chithandizo ndi mankhwala amodzi), pamene zochitika zolimbitsa thupi pamlingo woyenera komanso zakudya zopangidwa mwapadera zokhala ndi chakudya chochepa cha mafuta sizikukwanira pakulamulira kwazizindikiro za shuga,
• Ngati chithandizo cha mankhwala ndi Glucophage ndi mawonekedwe ake chikutsutsana pazifukwa zilizonse kapena mankhwalawa salola anthu.
• Mankhwala ophatikizika pamodzi ndi kugwiritsa ntchito munthawi yomweyo mankhwala ena ochepetsa shuga, ngati chithandizo chotere sichikubweretsa njira zothandizira achire.

Mankhwalawa sanatchulidwe kuchepa thupi.

Kumwa mankhwala a shuga

Mankhwalawa amagwiritsidwa ntchito pokhapokha. Mutha kuchita jakisoni pamimba, ntchafu, phewa. Intramuscular kapena intravenous management sikoletsedwa. Mutha kubayira jakisoni nthawi iliyonse masana, mosasamala zakudya.

Ndi monotherapy, 0,75 mg uyenera kuperekedwa. Pankhani ya chithandizo chophatikiza, 1.5 mg ya yankho iyenera kuperekedwa. Kwa odwala azaka zapakati pa 75 ndi kupitirira, 0,75 mg ya mankhwalawa amayenera kuperekedwa, mosasamala mtundu wa chithandizo.

Ngati mankhwalawa adawonjezeredwa kwa mankhwala a Metformin ndi mankhwala ena ochepetsa shuga, ndiye kuti mlingo wawo suwosinthidwa. Pochiza ndi analogues ndi zotumphukira za sulfonylurea, prandial insulin, ndikofunikira kuchepetsa kuchuluka kwa mankhwalawa kuti mupewe chiopsezo cha hypoglycemia.

Ngati mlingo wotsatira wa mankhwalawo watayika, ndiye kuti uyenera kutumikiridwa posachedwa, ngati masiku opitilira atatu atatsala jakisoni wotsatira. Ngati masiku osakwana 3 asiyidwa jakisoni asanachitike, ndiye kuti kutsata kwotsatira kumapitilira malinga ndi dongosolo.

Mankhwalawa amagwiritsidwa ntchito pokhapokha. Mutha kuchita jakisoni pamimba, ntchafu, phewa.

Kuyambitsa kumatha kuchitika pogwiritsa ntchito cholembera. Ichi ndi chipangizo chimodzi chokhala ndi 0,5 ml ya mankhwala omwe ali ndi yogwira ya 0,5 kapena 1.75 mg. Cholembera chimayambitsa mankhwalawo atangosinikiza batani, pomwepo amachichotsa. Zotsatira za jakisoni motere:

• chotsani mankhwalawo mufiriji ndikuwonetsetsa kuti chizindikirocho ndichabwino,
• yang'anani cholembera
• sankhani jakisoni (mutha kudziyambitsa nokha m'mimba kapena ntchafu, ndipo wothandizira akhoza kupanga jekeseni m'mbali mwa phewa),
• vula chovala, ndipo musakhudze ndi singano yosabala,
• kanikizani pansi pakhungu pamalowo jekeseni, kuzungulira mphete,
• kanikizani ndikudina batani m'malo ano mpaka litadina,
• pitilizani kukanikiza maziko mpaka kudina kwachiwiri
• chotsani chogwirizira.

Pang'onopang'ono, mankhwalawa amatha kubayidwa nthawi iliyonse masana, mosasamala zakudya.

Matumbo

Kuchokera kugaya ziwalo za odwala, nseru, kutsegula m'mimba, ndi kudzimbidwa zimawonedwa. Nthawi zambiri pamakhala zochitika zakuchepa kwa kudya kwa anorexia, bloating ndi gastroesophageal matenda. Nthawi zina, kuvomereza kumapangitsa kuti pakhale pancreatitis yovuta kwambiri, yomwe imafunikira opaleshoni yofunikira mwachangu.

Pakati mantha dongosolo

Pafupifupi, kuyambika kwa mankhwalawa kunayambitsa chizungulire, minyewa.

Nthawi zina, munthawi ya chithandizo chamankhwala, odwala amawona mawonekedwe am'mimba ndi kudzimbidwa.
Mwa odwala ena, mankhwalawa amayambitsa nseru.
Pa chithandizo, chizungulire sichimachotsedwa.Momwe thupi limasokoneza.

Nthawi zambiri, odwala amakumana ndi Quincke edema, uritisaria wamkulu, zotupa zambiri, nkhope, milomo ndi mkanda. Nthawi zina mantha a anaphylactic amakula. Odwala onse omwe amamwa mankhwalawo, ma antibodies ena aomwe amapangira, aaggututide, sanapangidwe.

Nthawi zina, pakhala zochitika zakumaloko zomwe zimakhudzana ndikuyambitsa yankho pansi pakhungu - zotupa ndi zotupa. Zochitika ngati izi zinali zofooka ndipo zidapita mwachangu.

Zokhudza mphamvu pakuwongolera njira

Ndikofunika kuchepetsa ntchitoyi pogwiritsa ntchito njira zovuta komanso kuyendetsa odwala omwe ali ndi chizolowezi chokhala ndi chizungulire komanso kutsika kwa kuthamanga kwa magazi.

Ngati pali chizolowezi chotsika magazi, ndiye kuti pakanthawi kokhala chithandizo ndikofunika kusiya kuyendetsa galimoto.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Palibe chidziwitso chokhudzana ndi kuperekedwa kwa mankhwalawa panthawi yapakati. Kafukufuku wokhudzana ndi ntchito ya kudyaglutide mu nyama yathandizira kuzindikira kuti ili ndi poizoni pa mwana wosabadwayo. Pachifukwa ichi, kugwiritsidwa ntchito kwake mu nthawi ya phwando ndizoletsedwa.

Mzimayi akulandila chithandizo ndi mankhwalawa atha kukonzekera kutenga pakati. Komabe, zizindikilo zoyambirira zikaonekera zomwe zikuonetsa kuti mayiyo apezeka, njira yothetsera mankhwalawa iyenera kuthetsedweratu ndipo analogue yotetezayo iyenera kulembedwa. Simuyenera kutenga chiopsezo mukupitiliza kumwa mankhwala panthawi yomwe muli ndi pakati, chifukwa kafukufuku amawonetsa kuti atha kukhala ndi mwana wolakwika. Mankhwala amatha kusokoneza mafupa.

Palibe chidziwitso cha mayamwidwe a lulaglutide mkaka wa amayi. Komabe, chiwopsezo cha zotsatira za poizoni kwa mwana sichitha, chifukwa chake, mankhwalawa amaletsedwa panthawi yoyamwitsa. Ngati pakufunika kupitiliza kumwa mankhwalawo, ndiye kuti mwana amasinthidwa kudyetsa mankhwala osokoneza bongo.

Palibe chidziwitso chokhudzana ndi kuperekedwa kwa mankhwalawa panthawi yapakati.

Kuchita ndi mankhwala ena

Milandu yodziwika kwambiri yogwirizana ndi mankhwalawa ndi awa:

1. Paracetamol - kuchuluka kwa mankhwalawa sikofunikira, kutsika kwa mayiyo ndi kochepa.
2. Atorvastatin ilibe kusintha kofunikira pochiritsa mukamagwiritsidwa ntchito mosiyanasiyana.
3. Mankhwala ndi kuhlalaglutide, kuchuluka kwa digoxin sikofunikira.
4. Mankhwala amatha kupatsidwa mankhwala ena onse a antihypertensive.
5. Kusintha pakugwiritsa ntchito warfarin sikufunika.

Ngati mankhwala osokoneza bongo, zizindikiro za kuphwanya kwam'mimba zimawonedwa.

Zosungidwa zamankhwala

Cholembera chimbale chimasungidwa mufiriji. Ngati palibe zoterezi, ndiye kuti zimasungidwa kwa milungu yopitilira 2. Kutha kwa nthawi ino, kugwiritsa ntchito mankhwalawa sikuletsedwa, chifukwa amasintha malowo ndikuyamba kufa.

Mankhwalawa sangaphatikizidwe ndi mowa.

Ndemanga za Trulicity

Irina, wodwala matenda ashuga, wazaka 40, ku Moscow: "Mankhwalawa akuwonetsa kugwiritsidwa ntchito bwino kwa mankhwalawa a matenda a matenda a shuga a mtundu wa 2. Ndimamupatsa mankhwala omwe amawonjezeredwa ngati mankhwala a Metformin ndi mawonekedwe ake. amawongolera kuchuluka kwama glucose mukatha kudya ndikulepheretsa kukula kwa mitundu yoopsa ya hyperglycemia. "

Oleg, endocrinologist, wazaka 55, Naberezhnye Chelny: "Ndi chida ichi ndikotheka kuwongolera moyenera njira ya odwala osagwirizana ndi insulin omwe ali m'magulu osiyanasiyana a odwala. Ndimapereka mankhwala ngati mankhwala a Metformin sabweretsa zotsatira zofunikira komanso mapiritsi a Glucofage wodwalayo akadali shuga wokwera. Zizindikiro za matenda ashuga ndipo zimatsimikizira mitengo yokhazikika. "

"Trulicity pamafunso ndi mayankho" "Zochitika ku Russia ndi Israel: chifukwa chake odwala T2DM amasankha Trulicity" Trulicity ndiye woyamba ku Russia aGPP-1 wogwiritsidwa ntchito kamodzi pa sabata "

Svetlana, wazaka 45, Tambov: "Mothandizidwa ndi chinthucho, ndimatha kukhalabe ndi thanzi labwino. Ndikamamwa mapiritsiwa, ndimakhalabe ndi shuga wambiri, ndimatopa, ndimva ludzu, nthawi zina ndimalephera chifukwa cha kuchepa kwambiri kwa shuga. Mankhwalawa adathetsa zovutazi, tsopano ndiyesera sungani kuchuluka kwa shuga m'magazi anu. "

Sergey, wazaka 50, ku Moscow: "Chida chothandiza kuthana ndi matenda a shuga. Ubwino wake ndikuti muyenera kupaka jakisoni kamodzi pa sabata. Ngati mugwiritsa ntchito mankhwalawa munthawi imeneyi, palibe zotsatirapo zake. "glycemia yakhazikika, thanzi layamba bwino. Ngakhale mtengo uli wokwera, ndikufuna kukonza kupitiliza chithandizo."

Elena, wazaka 40, St. Petersburg: "Kugwiritsa ntchito mankhwalawa kumakuthandizani kuti muchepetse matenda ashuga ndikuchotsa zizindikiro za matendawa. Patatha jekeseni wapansi, ndinazindikira kuti cholembera cha shuga chatsika, kunayamba bwino, kutopa kwatha. mita sikusonyeza pamwamba pa 6 mmol / l. "

Forsiga (dapagliflozin)

Chida ichi chimalepheretsa kuyamwa kwa glucose mutatha kudya ndikuchepetsa kuchuluka kwake. Mtengo - kuchokera ku 1800 rubles ndi pamwambapa. Amapanga Bristol Myers, Puerto Rico. Kuletsedwa kuchitira ana ndi amayi apakati, komanso okalamba.

Kugwiritsa ntchito kulikonse kwa analogi kuyenera kuvomerezedwa ndi dokotala. Kudzichitira nokha mankhwala ndikosavomerezeka!

Trulicity ili ndi mayankho abwino kuchokera kwa odwala. Anthu odwala matenda ashuga amatamandira mankhwalawa kamodzi pakanthawi kamodzi. Zimadziwikanso kuti mavuto ena samachitika kawirikawiri, ndipo mankhwalawa ndi oyenera nthawi zonse.

Oleg: “Ndili ndi matenda ashuga. Nthawi inayake, ngakhale adatsata chakudya, mapiritsiwo adasiya kuthandiza. Adotolo adandisamutsira ku Trulicity, ndikuti mankhwalawa ndi osavuta. Zotsatira zake, ngakhale zili zotsika mtengo, ndizabwino kwambiri ndipo zimathandiza ndi zilonda zonse za matenda ashuga. Shuga umagwira, ndipo ngakhale kulemera kumayambiranso. Ndimakondwera ndi mankhwalawa. ”

Victoria: “Dokotalayo anakhazikitsa Trulicity. Poyamba ndidali wotetezedwa ndi mtengo, komanso ngakhale kuti muyenera kuchita jakisoni imodzi pa sabata. Mwanjira yachilendo, ndimaganiza kuti ndi mtundu wina wa mankhwala osathandiza. Koma kwa miyezi ingapo tsopano ndakhala ndikugwiritsa ntchito izi popanda ndalama zowonjezera. Shuga ndi okhazikika, monganso kulemera. Palibe zoyipa, komanso momwe zidakhalira - ndidachita jakisoni imodzi, ndipo kwa sabata lathunthu ndidalibe mavuto. Ndimakonda kwambiri mankhwalawa. ”

Dmitry: “Bambo anga ndi odwala matenda ashuga. Tinayesetsa kugwiritsa ntchito mankhwala osokoneza bongo, patapita nthawi onse anasiya kuchita zinthu. Ndibwino kuti adakali wokalamba - ali ndi zaka 60 zokha, choncho dotolo adadzipereka kuyesa Trulicity, yoyenera anthu okalamba. Chipangizocho ndiokwera mtengo, koma chothandiza. Jakisoni imodzi yokha - ndipo sabata yonseyo bambo anga alibe mavuto ndi shuga. Zimakhala zochititsa manyazi pang'ono kuti mankhwalawa ndi atsopano, sakukwanira aliyense, koma abambo anga akhuta. Iye akuti ngakhale mavuto ena azaumoyo apita. Ndipo kunalibe zotsatirapo zake. Ndiye mankhwalawa ndi abwino. ”

Gulu la Nosological (ICD-10)

Zisonyezero za Trulicity ya mankhwala ®

Trulicity ® imawonetsedwa kuti igwiritsidwe ntchito kwa odwala akuluakulu omwe ali ndi mtundu wa 2 matenda a shuga kuti athandizire kuwongolera glycemic:

mu mawonekedwe a monotherapy ngati zakudya ndi masewera olimbitsa thupi sizipereka chiwongolero chofunikira cha glycemic mwa odwala omwe sawonetsedwa kugwiritsa ntchito metformin chifukwa chosalolera kapena kuponderezana,

mwanjira yophatikiza mankhwala osakanikirana ndi mankhwala ena a hypoglycemic, kuphatikiza insulin, ngati mankhwalawa pamodzi ndi zakudya komanso kuchita masewera olimbitsa thupi samapereka kuyenera kwa glycemic.

Mimba komanso kuyamwa

Palibe zosowa pakugwiritsa ntchito lulaglutide mwa amayi apakati kapena kuchuluka kwawo kuli kochepa.

Kafukufuku wazinyama awonetsa kawopsedwe akubereka, motero kugwiritsa ntchito saglutide kumatsutsana panthawi yapakati.

Palibe chidziwitso pazolowera kwa amoglutide kulowa mkaka wa m'mawere. Chiwopsezo cha akhanda / makanda sichingadziwike kuti. Kugwiritsa ntchito gawoglutide nthawi yoyamwitsa kumatsutsana.

Mlingo ndi makonzedwe

P / Cmpaka pamimba, ntchafu kapena phewa.

Mankhwala sangathe kulowa / mkati kapena / m.

Mankhwalawa amatha kutumikiridwa nthawi iliyonse ya tsiku, mosasamala kanthu ndi chakudya.

Monotherapy. Mlingo wovomerezeka ndi 0.75 mg / sabata.

Kuphatikiza mankhwala Mlingo woyenera ndi 1.5 mg / sabata.

Odwala azaka zapakati pa 75 ndi kupitilira apo, mankhwalawo oyamba a mankhwalawa ndi 0.75 mg / sabata.

Pamene kuhlalaglutide ikawonjezeredwa ku mankhwala omwe alipo ndi metformin ndi / kapena pioglitazone, metformin ndi / kapena pioglitazone zitha kupitilizidwa pa mlingo womwewo. Pamene kuhlalaglutide ikawonjezeredwa pamankhwala apano a mankhwala a sulfonylurea kapena insulin, kuchepetsedwa kwa mankhwala a sulfonylurea kapena insulin kungafunike kuchepetsa chiopsezo cha hypoglycemia.

Zowonjezera zowunikira za glycemia ya kusintha kwa mlingo wa siphgutut sikofunikira. Zowonjezera zowunikira za glycemic zingafunikire kuti musinthe mlingo wa zotuluka za sulfonylurea kapena prandial insulin.

Dumphani mlingo. Ngati mulingo wa Trulicity ® unaphonya, uyenera kutumizidwa mwachangu, ngati masiku atatu asiyidwa mlingo wotsatira usanaperekedwe (maola 72). Ngati pasanathe masiku atatu (maola 72) kuti mulandire mlingo wotsatira womwe waperekedwa, ndikofunikira kudumphira pakumwa mankhwala ndikukhazikitsa mlingo wotsatira malinga ndi dongosolo. Munthawi zonsezi, odwala amatha kuyambiranso regimen kamodzi pa sabata.

Tsiku loperekera mankhwala lingasinthidwe ngati kuli kofunikira, malinga ngati mlingo womaliza unaperekedwa masiku osachepera atatu (maola 72) apitawo.

Magulu apadera a odwala

Ukalamba (woposa zaka 65). Kusintha kwa Mlingo kutengera msinkhu sikofunikira. Komabe, zokumana nazo za odwala omwe ali ndi zaka ≥75 ndizochepa kwambiri; mwa odwala, mankhwalawa oyambira a mankhwalawa ndi 0.75 mg / sabata.

Matenda aimpso. Odwala ndi mkhutu aimpso ntchito ofatsa kapena zolimbitsa mwamphamvu, kusintha kwa mankhwala sikofunikira. Pali zambiri zomwe zimagwiritsidwa ntchito pakugwiritsa ntchito kuhlalaglutide kwa odwala omwe ali ndi vuto lowonongeka la impso (GFR 2) kapena kulephera kwa gawo lachiwindi, motero kugwiritsa ntchito kosglutide pakali pano sikulimbikitsidwa.

Kuwonongeka kwa chiwindi. Odwala omwe ali ndi vuto la chiwindi, kusintha kwa mankhwalawa sikofunikira.

Ana. Chitetezo ndi kugwira ntchito kwa dzuwaglutide mwa ana ochepera zaka 18 sizinakhazikitsidwe. Palibe zambiri zomwe zilipo.

Malangizo pakugwiritsira ntchito mankhwala Trulicity ® (lulaglutide), yankho la sc. 0.75 mg / 0.5 ml kapena 1.5 mg / 0.5 ml mu cholembera chogwiritsa ntchito kamodzi kamodzi pa sabata

Zambiri pa syringe pen imodzi ya Trulicity ®

Muyenera kuwerengera mosamala ndi kwathunthu izi Malangizo Ogwiritsira Ntchito ndi Malangizo pakugwiritsira ntchito mankhwalawa musanayambe kugwiritsa ntchito cholembera chogwiritsa ntchito mankhwala amodzi a Trulicity ®. Muyenera kukambirana ndi dokotala wanu za momwe mungagwiritsire ntchito bwino Trulicity ®.

Cholembera cha syringe chogwiritsidwa ntchito kamodzi pa mankhwala a Trulicity ® ndi chida chinagwiritsira ntchito, chodzaza ndi utsi wa mankhwala, okonzeka kugwiritsa ntchito. Cholembera chilichonse cha syringe chimakhala ndi mlingo umodzi wa sabata iliyonse wa Trulicity ® (0.75 mg / 0.5 ml kapena 1.5 mg / 0.5 ml). Adapangira kukhazikitsa mlingo umodzi wokha.

Mankhwala Trulicity ® imayendetsedwa kamodzi pa sabata. Wodwalayo akulimbikitsidwa kuti alembepo kalendala kuti asayiwale za kuyambitsidwa kwa mlingo wotsatira.

Wodwalayo akakanikiza batani jakisoni wobiriwira wobiriwira, cholembera chimodzicho chimalowetsa singano pakhungu, ndikulowetsa mankhwalawo ndikutulutsa singano atatha jekeseni.

Musanayambe kugwiritsa ntchito mankhwalawa, muyenera

1. Chotsani kukonzekera mufiriji.

2. Chongani lembalo kuti muwonetsetse kuti mankhwala olondola atengedwa komanso kuti sanathe ntchito.

3. Yang'anani cholembera. Osamagwiritsa ntchito ngati zadziwika kuti cholembera sichingawonongeke kapena mankhwalawo ndi mitambo, asintha mtundu kapena ali ndi tinthu tosiyanasiyana.

Kusankha kwa malo oyambira

1. Dotolo yemwe akupezekapo akhoza kukuthandizani kusankha malo omwe ali ndi jekeseni oyenera odwala.

2. Wodwalayo amatha kudzipatsira mankhwalawo m'mimba kapena ntchafu.

3. Wina amatha kupatsa jakisoni m'dera la phewa.

4. Sinthani (sinthani) jakisoni wa mankhwalawa sabata iliyonse. Mutha kugwiritsa ntchito gawo lomweli, koma onetsetsani kuti mwasankha mfundo zingapo za jakisoni.

Kuti mupeze jakisoni, ndikofunikira

1. Onetsetsani kuti cholembera chatsekedwa. Chotsani ndikutaya chofewa chakumutu chophimba m'munsi. Osayikanso cap, ikhoza kuwononga singano. Osakhudza singano.

2. Kanikizani maziko ofikira pakhungu pamalo opaka jekeseni. Tsegulani potembenuza mphete yotseka.

3. Dinani ndikusunga batani jakisoni wobiriwira mpaka kumveketsa mawu.

4. Pitilizani kukanikiza gawo loyera pakhungu mpaka kuwonekera kwachiwiri kumveka. Izi zidzachitika pamene singano iyamba kubwereranso pambuyo pa 5-10 s. Chotsani cholembera pakhungu. Wodwalayo amaphunzira kuti jakisoni yatha pomwe gawo la imvi limawonekera.

Kusunga ndi kusamalira

Cholembera chimakhala ndi magalasi. Gwirani chida mosamala. Wodwala akakugwetsera pansi molimbika, osagwiritsa ntchito. Gwiritsani ntchito cholembera chatsopano cha jakisoni.

Sungani cholembera mu firiji.

Ngati sizotheka kusunga mufiriji mutagula mankhwala, wodwala amatha kusungitsa cholembera osazizira 30 ° C osaposa masiku 14.

Osamasula cholembera. Ngati cholembera cha syringe chawuma, osachigwiritsa ntchito.

Sungani cholembera mu makatoni ake oyambirira kuti mutetezedwe ku kuwala, kwa ana.

Chidziwitso chokwanira pakusungidwa koyenera kili mu malangizo ogwiritsira ntchito mankhwala.

Taya cholembera mu chidebe cha sharps kapena monga akuvomerezedwera ndi akatswiri azaumoyo anu.

Osabwezanso zotengera zazitali.

Muyenera kufunsa dokotala wanu za njira zotayira zomwe sizikugwiranso ntchito.

Ngati wodwala ali ndi vuto lowona, musagwiritse ntchito cholembera chogwiritsa ntchito Trulicity ® popanda thandizo la munthu wophunzitsidwa bwino ntchito.

Wopanga

Anamaliza kupanga mafomu ndi kupanga ma CD: Eli Lilly & Company, USA. Eli Lilly & Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA.

Kukhazikitsa kwachiwiri ndikupereka kuwongolera kwapamwamba: Eli Lilly ndi Company, USA. Eli Lilly & Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA.

Kapena "Eli Lilly Italy S.P.A.", Italy. Via Gramsci, 731-733, 50019, Sesto Fiorentino (Florence), Italy.

Ofesi yoyimira ku Russia: Ofesi yoyimira ku Moscow ya JSC "Eli Lilly Vostok S.A.", Switzerland. 123112, Moscow, Presnenskaya nab., 10.

Tele. ((495) 258-50-01, fakisi: (495) 258-50-05.

Bungwe lalamulo lomwe dzina lake limalembetsedwa: Eli Lilly Vostok S.A. Switzerland 16, msewu waukulu wa Cocquelico 1214 Vernier-Geneva, Switzerland.

TRULISITI ® ndi chizindikiro cha Ely Lilly & Company.

Kufotokozera za mankhwalawa

Trulicity ndi choyerekeza chamtsogolo. Makamaka, Trulicity ndi glucagon-peptide-1 (GLP-1) receptor agonist wokhala ndi 90% amino acid sequology homology wokhala ndi endo native GLP-1 (7-37). GLP-1 (7-37) imayimira 20% ya chiwerengero chonse chozungulira cha GLP-1. Trulicity imamangirira ndikuyambitsa zolandila za GLP-1. GLP-1 ndi gawo lofunikira la shuga la homeostasis, lomwe limatulutsidwa pambuyo pakudya zamagalimoto kapena mafuta. Ndikofunikira kugula Trulicity ndi malire, popeza pali mwayi wolumpha mlingo, chifukwa cha zifukwa zokhudzana ndi zaka.

Migwirizano ndi magwiritsidwe akusungidwa

Kusungika kwa Trulicity kumakhala pansi pa malamulo awa: • Tayetsani mankhwalawo ngati ali ndi tinthu tambiri, • Taya gawo losagwiritsidwa ntchito la mankhwalawo, • Osachoka kuti agwiritse ntchito mtsogolo, • Osatulutsa kutentha, • Osamagwiritsa ntchito ngati mankhwala atapanga mazira, kuwongolera dzuwa, • Sungani pamtunda wotsika ndi 30 ° C, kutali ndi malo otentha, kwa masiku 14, • Sungani m'bokosi lomwe likupezeka. Sungani mankhwalawo kutali ndi ana, popeza pali chiopsezo cha kuwonongeka kwa ma ampoules. Mtengo wa Trulicity umasiyanasiyana pamitundu 10 rub 000 rubles.

Mimba komanso kuyamwa

Gwiritsani ntchito pokhapokha ngati mapindu ake akutsimikizira kuti chiwopsezo cha mwana sichitha. Mankhwala omwe amaphatikizidwa ndi chiopsezo cha zolephera kapena kusokonekera. Zowopsa zomwe sizingatheke sizingadziwike. American College of Obstetrics and Gynecologists (ACOG) ndi American Diabetes Association (ADA) akupitiliza kuvomereza insulini ngati njira yokhayo yothandizira azimayi omwe ali ndi matenda osokoneza bongo a mellitus kapena gestationalabetes mellitus (GDM) ofuna mankhwala. Insulin sikuwoloka placenta. Sizikudziwika ngati matupi amtundu wa munthu amapukusidwa. Kuchepa kwa thupi kwa ana kumawonedwa ndi makoswe omwe amathandizidwa ndi mankhwalawa panthawi yokhala ndi pakati.