Momwe mungagwiritsire ntchito Agapurin?

Agapurin ndi antispasmodicothandizira ochizira ndipo ali m'gululi purines. Machitidwe pentoxifyllineCholinga chake ndi kukonza mikhalidwe yazikhalidwe magazi ndikupeza kuyesa. Kugwiritsa ntchito bwino pentoxifylline kuwonetsedwa chifukwa cha kupsinjika phosphodiesterasendi kuwonjezera chidwi ATPmu maselo ofiira amwazindi cAMPmu kuchuluka kwa mapulateletindi kudzaza komwe mphamvu. Njira iyi yochitira zinthu imabweretsa zowoneka Vasodilation, kuchepa kwa kukana kwathunthu kwa ziwiya zotumphukira, kuchuluka kwa miniti ndikugwedezeka kuchuluka kwa magazi ndipo zimachitika popanda kusintha kwakukulu Kufika pamtima.

Pentoxifyllineamakhudza kwambiri ziwiya zam'mapapo ndi mitsempha yam'mimba, potero kuchulukitsa kwa kutulutsa kwa oksijeni kumitsempha ndi kwa minofu ya mtima (antianginal kuchitapo kanthu) komanso kumakulitsa kamvekedwe ka minofu ya kupuma (diaphragm ndi minofu yamimba). Pankhani yoyambira pentoxifyllinekuwonjezeka kumawonedwa kudzera m'mitsempha kufalitsa kozungulira ndi kuchuluka kuchuluka kwa magazikudutsa gawo la gawo. Mu ubongo mumakhala kuchuluka ATPndi kupititsa patsogolo ntchito zama bioelectric a chapakati mantha dongosolo. Kuchepa mamasukidwe amwazi ndi kuchuluka erythrocyte nembanemba elasticity (chifukwa cha mphamvu ya mankhwalawa opindika maselo ofiira amwazi) M'malo ovuta kufalikira kumawonjezeka kuyesa. Ndikulankhula kwapang'onopang'ono, mtunda woyenda kwambiri umakwera, komanso kuzungulira kumachepa ululu pakupumula komanso pafupipafupi kukokana usiku malekezero otsika (makamaka minofu ya ng'ombe).

Pentoxifyllineyodziwika ndi hepatic yachangu kagayidwe ndi kutulutsidwa kwa zinthu zingapo zomwe zimagwira mu metabolic. Chofunika kwambiri metabolites amaganizira1-3-carboxypropyl-3,7-dimethylxanthineomwe ndende yake ya plasma ndi yokwera kwambiri kuposa ma seramu pentoxifylline ndi 1-5-hydroxyhexyl-3,7-dimethylxanthineNthawi 5 zapamwamba za plasma pentoxifylline.

The bioavailability wa mankhwalawa amasinthasintha ndipo amasiyanasiyana pakati pa 6-32%. Kudya Kwapanthawi Imodzimodzi kumawonjezera Cmax pentoxifylline ndi 28%, ndi AUC yake ndi 13%, yokhala ndi Cmax 1-5-hydroxyhexyl-3,7-dimethylxanthine ukuwonjezeka ndi 20%.

Mukamamwa pakamwa, mapiritsi osavuta a TCmax pentoxifyllinendi mphindi 60, mukamamwa mapiritsi a retard - 120-240 mphindi. Pambuyo mphindi theka kulowetsedwa ndi pentoxifylline pa mlingo wa 200 mg, Vd yake ili pamlingo wa 168 malita, ndipo chilolezocho ndi 4500-5100 ml / min.

Kuwonedwa T1 / 2 pambuyo pa kukokana kwa 100 mg pentoxifyllinendi maola 1,1, pambuyo pakukonzekera kwamkati mapiritsi - 0,4-0.8 maola. T1 / 2 yazinthu ziwiri zofunika kwambiri zama metabolic zimachokera ku 1 mpaka 1.6 maola.

Kuchulukitsa kwa 94% kumachitika ndi impso ndi 4% ndi matumbo, mwa mawonekedwe a metabolites. Pafupifupi 90% amachotseredwa maola 4 oyambirira pentoxifylline.

Ndi kwambiri matenda a impso kuchedwa kwakwaniritsidwa kwa metabolites kumadziwika.

At matenda a chiwindi pali kuchuluka kwa bioavailability komanso kuwonjezeka kwa T1 / 2.

Zizindikiro zogwiritsidwa ntchito

Kugwiritsa ntchito Agapurin kukuwonetsedwa pochiza:

zotumphukira kuzungulira kwa matendazimachitika kumbuyo yotupa, matenda ashuga, njira atherosulinotic (kuphatikiza kulankhulirana pang'onopang'onozogwirizana ndi kusokoneza endarteritis, matenda ashuga angiopathy, atherosulinosis),
angioneuropathy(kuphatikiza acrocyanosis, paresthesia, Matenda a Raynaud),
trophic minofu zovutachifukwa cha pathologies venouskapena ochepa miccirculation (kuphatikiza chisanu, zigawenga ndi Zilonda za varicose),
matenda kufalikira kwa magazi muubongo ischemic etiology ya pachimake komanso yopanda vuto (incl. matenda atherosulinosis),
kuphwanya malamulomagazi ocular (kuphatikiza magazi osakwanira ku choroid ndi retina)
zinthu pambuyo sitirokomonga ischemicchoncho hemorrhagic,
kuvulala kwamitsempha magwiridwe khutu lapakati zooneka kusamva.

Contraindication

Kukhazikitsidwa kwa Agapurin ndikutsutsana kwathunthu mu:

kutchulidwa atherosulinosis(korona kapena korona),
wa mimba,
myocardial infaration (nthawi yake yovuta kwambiri)
porphyria,
yoyamwitsa,
zazikulu kutentha kwa mtima,
hemorrhagic stroke (nthawi yake yovuta kwambiri)
zanga zokha Hypersensitivitykuti pentoxifyllinendi / kapena zigawo zina za mankhwala,
osalamulirika ochepa hypotension,
retinal hemorrhage,
chachikulu magazi,
ali ndi zaka 18.

Contraindative zokhudzana ndi izi:

labala HERE,
CHF,
zilonda zam'mimba,
kulosera kwa ochepa hypotension,
kuchuluka kwa zotupa m'mimba,
chiwindi / matenda a impso,
machitidwe ogwira ntchito.

Zotsatira zoyipa

Zosangalatsa:

Machitidwe amanjenje:

Khungu:

Hyperemia ya nkhope,
misomali yothina
mafunde(nthawi zambiri pokhudzana ndi chifuwa chapamwamba ndi nkhope)
kutupa.

Dongosolo la mtima:

Matumbo:

atom yamatumbo,
kumverera kolemetsa m'mimba
kuchuluka cholecystitis,
kusanza / kusanza
kutulutsa magazi m'mimba,
kukana kulakalaka,
cholestatic hepatitis.

Ziwalo za Hematopoietic:

pancytopenia,
hypofibrinogenemia,
thrombocytopenia
kukula kwa magazi ochokera ku ziwiya zapakhungu,
leukopenia.

Mawonekedwe a mziwi:

Zizindikiro zantchito:

kuchuluka kwawonjezeka chiwindi transaminase.

Agapurin, malangizo ogwiritsira ntchito

Malangizo ogwiritsira ntchito Agapurin amapereka pakamwa pafupipafupi (nthawi imodzi masana) mapiritsi osavuta komanso mapiritsi obwezera. Ndikofunika kumwa mapiritsi atangomaliza kudya.

Mukamapereka mankhwala pogwiritsa ntchito mapiritsi amodzi, sabata yoyamba ya mankhwala imachitika muyezo wa 200 mg (mapiritsi 2) ndi katatu patsiku. Ngati mawonetseredwe a zofooka kuchokera pakati mantha dongosolo, m'mimba thirakiti kapena lakuthwa kutsitsa magaziMlingo wake uyenera kuchepetsedwa osungidwa pafupipafupi pakumwa mapiritsi.

Ndi mankhwala, monga ulamuliro, kudya katatu kwa 100 mg (piritsi 1) la Agapurin ndi mankhwala kwa maola 24, ndi mlingo wovomerezeka wa tsiku lililonse wa 1200 mg.

Pankhani yoonekera kulephera kwa aimpso ndi mulingo creatinine mopitilira 400 mmol / l, kutsitsa kwa 30-50% kumachitika.

Mukamagwiritsa ntchito mitundu yayitali ya mankhwalawa, mapiritsi a Agapurin achigonjetse, njira yothandizira achire ndi mankhwala amayikidwa payekhapayekha malinga ndi chithunzi cha matenda omwe adapezeka ndi chithandizo chamankhwala omwe amapangidwa.

Mapiritsi a Agapurin 400 CP ayenera kumwedwa katatu patsiku, 600 CP - kawiri pa tsiku. Mlingo wovomerezeka tsiku lililonse ndi 1200 mg.

At matenda a impso ndi CC zosakwana 30 ml / min, kutalika kwa maola 24 kungatenge mapiritsi 2 a 400 mg.

Ndi kwambiri matenda a chiwindikuchepetsa kuchuluka kwa mapiritsi a nthawi yayitali kumafunikira, poganizira kulekerera kwa munthu pentoxifylline.

Pankhani yoika Agapurin achigonjetse odwala hypotensionkapena anthu amakonda kutsitsa magazi (Matenda a mtima wa Ischemiczamankhwala stenosisbongo, etc.) chithandizo chiyenera kuyamba ndi kuchuluka kwamankhwala pentoxifylline, ndi kuchuluka kwawo pang'onopang'ono pamakhalidwe oyenera.

Agapurin jakisoni njira angathe kutumikiridwa kudzera m`mitsempha, magazi kapena intramuscularly, ndi wodwala thupi yopingasa.

Kulowetsedwa kwa mtsempha wa magazi kumachitika tsiku lililonse la 100 mg (1 ampoule), kusungunuka mu 250-500 ml ya mayankho sodium kolorayidi (0.9%) kapena dextrose (5%) kwa maola 1.5-3. Poyankha molimbikitsa kulowetsedwa kosatha, ndizotheka kubwereza muyeso. Zolemba malire patsiku, mutha kulowa / mu 300 mg.

Intraarterial makonzedwe amapangidwa koyambirira kwa 100 mg kusungunuka mu 20-50 ml ya yankho sodium kolorayidi (0.9%). M'tsogolomu, 200-300 mg mu 30-50 ml ya yankho amatsimikiza sodium kolorayidi(0.9%). Mlingo wa makonzedwe a 100 mg wa Agapurin ayenera kukhala osachepera mphindi 10. Pankhani ya wonenedwayo mtima atherosulinosisbongokukhazikitsidwa kwa yankho mu carotid artery sikuloledwa.

At matenda a impso ndi CC zosakwana 10 ml / min, mlingo wa jekeseni wa Agapurin umachepetsedwa ndi 30-50%.

Jekeseni wa mnofu wa njira ikuchitika 1-2 zina 24 mawola mlingo wa 100 mg (1 ampoule).

Bongo

Ndi mankhwala osokoneza bongo a Agapurin akuti: mawonetseredwe kufooka, kutsitsa magazikumverera chizungulirehyperthermia tachycardia, kukomokakuchuluka kugona, kusinthika, kulephera kudziwawamanjenje chisangalalotonic-clonic kukokanazochitika kutulutsa magazi m'mimba (mwachitsanzo, kusanza "malo a khofi").

Chithandizo cha zinthu zoterezi chikuyenera kukhala chofanana ndi zomwe zimawonedwa, ndikukhala (ngati ndikofunikira) kuthamanga kwa magazi ndi kupuma ntchito.

Kuchita

Kugwiritsa ntchito pamodzi kwa Agapurin ndi ena xanthineszingayambitse kuchulukachisangalalo chamanjenje.

Zotsatira pentoxifyllinezitha kuwonjezera zochita valproic acidmankhwala omwe amakhudza magazi m'magazi (manga, anticoagulants), komanso maantibayotiki (kuphatikiza cephalosporins).

Agapurin imathandizira kugwira ntchito mwamphamvu insulin, antihypertensiveamatanthauzakomanso mkamwa mankhwala a hypoglycemic.

Njira yosakanikirana ndi Cimetidine zitha kukulitsa plasma pentoxifylline, zomwe zimawonjezera mwayi wazotsatira zoyipa.

Malangizo apadera

Mankhwala a Agapurin ayenera kuchitika mosalekeza kuthamanga kwa magazi. Odwala CHFmuyenera kukwaniritsa kufalitsa magazi.

Ndi kufanana phwando anticoagulantsyang'anirani mosamala magazi.

Kugwiritsa ntchito Mlingo waukulu wa Agapurin zochizira odwala omwe ali nawo matenda ashugakuvomera mankhwala a hypoglycemiczingayambitse mapangidwe otchulidwa hypoglycemiapamafunika kusintha dongosolo.

Odwala omwe apitapo kale othandizira opaleshonikuganizira kuyenera kuyang'aniridwa mwadongosolo hematocrit ndi hemoglobin.

Mukamazindikira wodwala understatedkapena kuthamanga kwa magazi Mlingo wothandiza wa Agapurin uyenera kugwiritsidwa ntchito.

Zochizira odwala okalamba, kusintha kwa mankhwalawa kungakhale kofunikira, chifukwa kuchepa kuchuluka kwa zotulutsa.

At chikongaOdwala atha kuwona kuchepa kwa chidziwitso chokwanira cha Agapurin.

Kuphatikiza kwa jekeseni wa jekeseni wa kulowetsedwa ndi kulowetsedwa kuyenera kuyang'anidwa padera.

Theonicol,
Xanthinol Nicotinate.

Trental,
Maluwa,
Pentiline,
Wachisoni,
Kusinthasintha,
Pentoxifylline.

Chifukwa chachitetezo chosadziwika bwino komanso chokwanira cha Agapurin muubwana, sichinapangidwe kuti azichiritsa odwala osaposa zaka 18.

Mimba (ndi mkaka wa m'mawere)

M'milandu yoposa 90%, ndemanga za Agapurin ndi zabwino. Odwala omwe amamwa mankhwalawa nthawi zambiri amakhutira ndi momwe amagwirira ntchito ndipo samazindikira kukula kwa zovuta zilizonse.

Mutha kupezanso malingaliro ndi malingaliro pa kugwiritsa ntchito Agapurin mkati zomanga, pa cholinga cha otchedwa kupompa(kuphatikizika ndi kukula kwa minofu minofu itatha mphamvu). Pankhaniyi, mankhwalawa amakhala ngati njira yachangu kwambiri kupindula kwa minofuchifukwa chakusintha kuyesam'misempha. Ndikofunika kudziwa kuti musanatenge Agapurin zomangamuyenera kufunsa dokotala wanu, chifukwa thanzi labwinobwino silimagwirizana ndi ziwalo zamthupi ndi kachitidwe ka thupi.

Mawonekedwe ndi mawonekedwe a mankhwalawa

Kodi Agapurin ali ndi dzina lapadziko lonse lapansi? Pentoxifylline ndi dzina lachiwiri.

Pakadali pano, mankhwalawa akupezeka m'mitundu iwiri:

Mapiritsi a Biconvex, wokutira (oyera) komanso wokhala ndi sheen wonyezimira. Mankhwalawa ali ndi yogwira pentoxifylline ndi zina zowonjezera (lactose monohydrate, wowuma chimanga, anhydrous colloidal silicon, talc ndi magnesium stearate). Ponena za chipolalachi, chimakhala ndi zinthu monga sodium carmellose, crystalline sucrose, sucrose wa ufa, talc, methyl paraben, titanium dioxide, anhydrous colloidal silicon ndi chingamu.
Solution (yomveka, yopanda utoto), yopangira jakisoni. Mankhwalawa amaphatikizapo pentoxifylline, sodium chloride ndi madzi a jakisoni.

Ndikufuna kunena kuti m'makatani a pharmacy mutha kupezanso mankhwala analogue monga Agapurin Retard. Malangizidwe a mankhwalawa akuti ndikutenga nthawi. Imapezeka m'mapiritsi, omwe amaphatikizidwa ndi film filming. Mankhwalawa ali ndi pentoxifylline ndi zina zowonjezera monga hypromellose, povidone, talc ndi magnesium stearate.

Mankhwala

Kodi Agapurin ndi chiyani? Malangizo ogwiritsira ntchito akuti mankhwala awa ndi antispasmodic ndipo ndi a gulu la purines. Amasintha kwambiri magazi m'magazi, komanso kuphatikiza kwachuma chake. Mfundo zoyenera kuchitira mankhwalawa ndizoletsa phosphodiesterase ndikuonjezera zomwe ATP imakhala m'magazi ofiira a magazi ndi ma cAMP m'mapulateleti okhala ndi mphamvu yayitali nthawi imodzi. Zotsatira zake, vasodilation ndi kuchepa kwa mtima kukana kwamitsempha (zotumphukira) kumachitika, komanso kuwonjezeka kwa miniti ndikuchepa kwa magazi osasinthika kwakukulu pamtima.

Limagwirira a zochita za mankhwala

Kodi makina a zochita za mankhwala "Agapurin" ndi ati? Malangizo ogwiritsira ntchito amapereka yankho lokwanira kufunso. Pambuyo pakugwiritsira ntchito mankhwalawa, mitsempha ya coronary imakulitsidwa, kenako kuperekanso kwa okosijeni m'matumbo am'mapapu ndi myocardium kumawonjezeka, mphamvu ya antianginal imawonekera ndipo mpweya wa magazi umayamba kuyenda bwino.

Tiyeneranso kudziwa kuti mankhwala omwe amaperekedwa amatha kuwonjezera kamvekedwe ka minofu yopuma, makamaka, diaphragm ndi minofu yolumikizana.

Ndi jakisoni wamkati, amatsogolera kuzungulira kozungulira, komanso kukwera kwa kuchuluka kwa magazi omwe amayenda kudutsa gawo limodzi. Kuphatikiza apo, mankhwalawa amatsogolera kuwonjezeka kwa adenosine triphosphate mu ubongo ndipo amathandizanso pa ntchito ya bioelectric yamanjenje.

Malinga ndi malangizo, mankhwalawo omwe atchulidwa amatha kuchepetsa kukhuthala kwa magazi, kuonjezera kukhuthala kwa ma membala a erythrocyte ndikusintha ma cellcirculation oyenda ndi magazi.

Ndi mankhwala ati omwe "Agapurin" ali nawo? Malangizo ogwiritsira ntchito akuti ndi zotupa zokhudzana ndi mitsempha (zotumphukira), mankhwalawa angayambitse kuchotsedwa kwa usiku kukokana m'mitsempha ya ng'ombe, ndikuwonjezera mtunda woyenda ndi kupweteka.

Pharmacokinetics

Mankhwala "Agapurin" amapangidwa mofulumira m'chiwindi. Pankhaniyi, metabolites yogwira imapangidwa.Kuphatikizika kwawo m'magazi kumakhala kambiri kangapo kuposa kugundidwa kwa chinthu chachikulu.

Mankhwala omwe aperekedwa akuwonetsedwa mu mawonekedwe a metabolites mu voliyumu ya 94%, ndipo otsala kudzera m'matumbo. Pakumatha maola 4 pambuyo pa kukhazikitsa, mankhwalawa amasiya kuchuluka kwa 90% ya mlingo womwe umagwiritsidwa ntchito. Zosasinthika, zimapukusidwa mu voliyumu ya 2%. Tiyeneranso kudziwa kuti chinthu chogwira ntchito pentoxifylline ndi metabolites sichimamangiriza mapuloteni amwazi.

Ndi vuto laimpso, kukonzanso kwa metabolite kumachepetsa. Ndi osagwira ntchito chiwindi ntchito, kuchuluka kwa theka moyo kumaonedwa, komanso kuchuluka bioavailability.

Mankhwala "Agapurin" (mapiritsi): malangizo ogwiritsira ntchito

Malinga ndi malangizo omwe aphatikizidwa ndi mankhwalawa, amayenera kumwa nthawi yofananayo patsiku atadya chakudya, kutsukidwa ndi madzi wamba. Mankhwala sayenera kutafuna.

Mlingo woyambirira wa mankhwalawa ndi 200 mg katatu patsiku. Ngati wodwala amakhala ndi chithandizo chambiri kapena ngati sakuvomereza bwino mankhwalawo, ndiye kuti mlingo umodzi umatha kuchepetsedwa ndi theka, koma nthawi yomweyo, kuchuluka kwa milingo kuyenera kusungidwa.

Mlingo wa tsiku lililonse wa mankhwalawa sayenera kupitirira 1200 mg.

Tsopano mukudziwa momwe mungagwiritsire ntchito mankhwala "Agapurin" (mapiritsi). Malangizo ogwiritsira ntchito mankhwala omwewo omwe amakhala ndi nthawi yayitali amakhala ndi zidziwitso zofanana. Komabe, mukamagwiritsa ntchito, kuchepa kwa mulingo wolandila ndikotheka.

Malangizo ogwiritsira ntchito jakisoni

Momwe mungagwiritsire ntchito mankhwalawa "Agapurin"? Mapiritsi amayikidwa ndi madokotala nthawi zambiri kuposa njira zovomerezeka. Ngati, pazifukwa zina, wodwalayo sangamwe mankhwalawo pakamwa, ndiye kuti jakisoni ndi mankhwala.

Mankhwala, opangidwa mwa njira yothetsera jakisoni, amatha kutumikiridwa mu imodzi mwanjira zotsatirazi:

Mothandizidwa. Zomwe zili pamapulogalamuwa ziyenera kuchepetsedwa mu 5% shuga kapena 250-500 ml ya sodium chloride solution (0.9%). Mankhwalawa amayenera kuperekedwa pang'onopang'ono, osapitirira 150 ml pa ola limodzi. Ngati wodwalayo alekerera bwino mankhwalawo, ndiye kuti mlingo wa tsiku ndi tsiku umaloledwa kuti uwonjezeke kukhala ma ampoules awiri, i.e. 200 mg.
Intramuscularly Mankhwalawa amatumizidwa 100 mg kawiri patsiku. Pankhaniyi, zomwe zili m'mapulogalamuwa siziyenera kuchepetsedwa.
Kwambiri. Chithandizo cha wodwalayo ziyenera kuyamba ndikuwonetsa ampoule umodzi, womwe umayenera kuchepetsedwa kale 20-50 ml ya isotonic sodium chloride. Ngati chithandizo cha nthawi yayitali chikufunika, mulingo womwewo ungakulidwe kupita ku ma ampoules a 2-3. Afunika kuchepetsedwa ndi 30-50 ml ya yankho.

Kuyenera kudziwitsidwa mwapadera kuti kuchuluka kwa mankhwalawa omwe amatsimikiziridwa kumadalira kokha ndi adokotala komanso pokhapokha pakulankhula ndi wodwala payekha.

Mankhwala "Agapurin": Zizindikiro zogwiritsidwa ntchito

Musanagwiritse ntchito mankhwalawa, muyenera kufunsa dokotala ndikuyezetsa. Kupatula apo, mankhwala amathandizidwa pokhapokha pang'onopang'ono. Tionanso mndandanda wawo.

Matenda amtundu wa Trophic omwe adayamba chifukwa cha kusakhazikika kwa ma venous kapena arcial microcirculation (mwachitsanzo, gangrene, zilonda za varicose, frostbite, etc.).
Kusokonezeka kwa kayendedwe ka magazi (zotumphukira), komwe kanapangidwa chifukwa cha kutupa, ma atherosulinotic ndi matenda ashuga. Komanso, mankhwalawa amalembedwa kuti akhale ndi "pakati", omwe amayamba chifukwa cha atherosulinosis, kufafaniza kwa endarteritis ndi matenda a shuga.
Ngozi yovuta kwambiri komanso yamphamvu kwambiri, yomwe imachokera ku ischemic. Komanso, mankhwalawa amagwiritsidwa ntchito popanga matenda a muubongo a chotupa, paresthesia, angioneuropathy, matenda a Raynaud ndi acrocyanosis.
Kuzungulira kwa magazi m'matumbo a ziwonetserozo (mu pachimake komanso kuzungulira kwazosakhazikika kwa mtima.
Mikhalidwe yomwe imachitika pambuyo pa kupweteka kwa ischemic kapena hemorrhagic.
Kusokonezeka kwa khutu lapakati la mtima, komwe kumayendetsedwa ndi kumva.

Kugwiritsa ntchito mosamala mankhwala

Mosamala kwambiri, mankhwalawa amayenera kugwiritsidwa ntchito mwa odwala omwe ali ndi vuto lotenga magazi kwambiri, ndi vuto la kuthamanga magazi, kulephera kwamtima (kuperewera), kukoka magazi, aimpso komanso kwa hepatic, komanso ku boma atachitidwa opaleshoni.

Zotsatira zoyipa

Kodi pali zovuta zina za mankhwala "Agapurin"? Mapiritsi, malangizo omwe aperekedwa pamwambapa, komanso yankho la jekeseni amatha kuyambitsa zovuta zingapo. Tiyeni tiwalingalire mwatsatanetsatane.

Matumbo dongosolo: cholestatic hepatitis, matumbo atomu, kuchulukitsa kwa cholecystitis, kamwa yowuma komanso kuchepa kwamtima.
Mchitidwe wamsempha: nkhawa, kugona tulo, chizungulire, kukokana komanso mutu.
Mitsempha yamagazi ndi khungu: chotupa, misomali yovunduka, kuyimitsidwa pakhungu, kusefukira kwa magazi mpaka pachifuwa ndi kumaso.
Mtima dongosolo: arrhythmia, cardialgia, kupita patsogolo kwa angina pectoris, tachycardia ndi kutsitsa magazi.
Hematopoietic ziwalo ndi hemostatic dongosolo: thrombocytopenia, leukopenia, pancytopenia, hypofibrinogenemia, magazi kuchokera m'matumbo, m'mimba, subcutaneous capillaries ndi mucous nembanemba.
Ziwalo zam'maso: kuwonongeka kwa mawonekedwe ndi scotoma.
Thupi lawo siligwirizana: kuyabwa, urticaria, angioedema ndi anaphylactic mantha.

Milandu yambiri

Kodi chingachitike ndi chiyani ngati ndidzagwiritsa ntchito Agapurin (400 mg, 600 mg, 1200 mg) mu milingo yayikulu? Pankhaniyi, wodwalayo amatha kuona zizindikiro zam'magazi monga kufooka, kuchepa kwamphamvu kwa magazi, chizungulire, tachycardia, kukomoka, kugona, kukomoka, kuzindikira, Hyperthermia, kuwonjezeka kwa manjenje, Zizindikiro za kutulutsa magazi m'matumbo (mwachitsanzo, kusanza " mabwalo a khofi ") ndikusinthika.

Pankhaniyi, chithandizo chamankhwala chofunikira chikufunika, chomwe chimalimbikira kuthamanga kwa magazi ndi ntchito yopuma.

Njira zosungira mankhwalawa, kuwunikira za, mtengo

Mankhwala "Agapurin" amagulitsidwa pafupifupi mankhwala onse. Mutha kugula mapiritsi 60 (100 mg) pa average ya 250 rubles okha aku Russia.

Ndemanga za odwala za mankhwalawa zili zabwino. Ndi chifukwa chake nthawi zambiri amalamula kuposa mankhwala ena kwa odwala omwe ali ndi mavuto amitsempha yamagazi.

Tiyeneranso kudziwa kuti mankhwalawa "Agapurin" pakupanga thupi ndiwotchuka kwambiri. Ndemanga za omanga thupi akuti chida ichi chiyenera kuonedwa mosiyana ndi mankhwala ena omwe amathandizira kusintha kwa magazi. Kupatula apo, ndizothandiza kwambiri komanso nthawi yomweyo zotsika mtengo.

Mankhwalawa ndi oyenera kuti othamanga azitha kumwa, popeza amapezeka osati mwanjira yothetsera jakisoni, komanso mawonekedwe a piritsi. M'mafakisi, chida ichi chimatha kupezeka pansi pa mayina ena omwe akumveka ngati "Pentoxifylline" kapena "Trental."

Cholinga chachikulu cha mankhwala omwe aperekedwawa ndikuwonjezera mamvekedwe amitsempha yamagazi, kuchepetsa mamasukidwe amwazi ndi kuwonjezera magazi. Zonsezi ndi njira yabwino yokwaniritsira kupopa pamasewera olimbitsa thupi, pakakhala kumva kupopa kwamphamvu kwa minofu yogwira ntchito.

Gwiritsani ntchito mankhwalawa kuti mumange omanga thupi omwe ali ndi chidwi ayenera kusamala kwambiri, chifukwa zimapangitsa kuyambitsa bongo ndi zovuta zingapo.

Sungani "Agapurin" makamaka m'malo amdima ndi owuma, momwe mulibe mwayi wa ana aang'ono. Pankhaniyi, kutentha kosungirako kwa mankhwalawa ndi madigiri 10-15 okha. Tsiku lake lotha ntchito likuwonetsedwa pamaphukusi ndipo lofanana zaka ziwiri. Pambuyo pa nthawi imeneyi, kugwiritsa ntchito mankhwala koletsedwa.

Pomaliza, tikuzindikiranso kuti simuyenera kudzipereka nokha mankhwalawa. Kutalika kwa chithandizo ndi mlingo uyenera kutsimikiziridwa ndi adokotala kwa wodwala wina.

Momwe mungatengere agapurin pomanga thupi

Panthawi yogwira ntchito, ndikofunikira kumwa mankhwalawa motere: katatu patsiku, mapiritsi awiri mutatha kudya. Pa masiku opanda maphunziro, piritsi 1 katatu patsiku komanso pakudya. Agapurin amatengedwa kwa milungu itatu, pambuyo pake muyenera kupuma kwa mwezi umodzi. Munthawi imeneyi, muyenera kupitiliza maphunziro kuti muyambe kumwa agapurin pamlingo watsopano, pogwiritsa ntchito zolemera zatsopano. Kugwiritsa ntchito mapiritsiwa kumaphatikizapo kugwiritsa ntchito madzi ambiri akumwa. Pomwe mankhwalawa akailowetsedwa mthupi ndi dontho, ndiye kuti mlingo ndi nthawi yolandiridwa zimasankhidwa payekha. Kulandilidwa kwa njirayi ndizovomerezeka bwino ndi dokotala kuti mudziteteze pazotsatira zoyipa.

Agapurin m'masitolo ogulitsa mankhwala amagulitsidwa pansi pa mayina monga trental ndi pentoxifylline. Amapezeka mwanjira ya mapiritsi ndipo amasiyana pamitengo yotsika mtengo kwambiri. Alumali moyo wa mankhwalawa ndi miyezi 24, ndipo chinthucho chimagula pafupifupi ma ruble 260 a mapiritsi 60 a 100 mg. Palinso mapaketi okhala ndi mapiritsi a 400 ndi 600 mg.

Kupanga ndi contraindication

Pentoxifylline ndichinthu chomwe chimagwiritsa ntchito mankhwalawa ndipo chimadziwika ndi yunifolomu komanso kulowa mwachangu mthupi. Pambuyo maola angapo, mutha kuzindikira kuchuluka kwake kwazonse zofunikira pambuyo pokhazikitsa. Thupi limachotsedwa m'thupi mothandizidwa ndi impso ndi matumbo.

Agapurin amagwiritsidwa ntchito ngati mankhwala pothandiza matenda a varicose, mitsempha ya chisanu, matenda osokoneza bongo, etc. Pomanga thupi sagwiritsidwa ntchito kawirikawiri, chifukwa chidziwitso chofunikira sichikupezeka, koma akatswiri odziwa masewera amathanso kusankha kumwa mankhwalawa. Nthawi yomweyo, mankhwalawa ali ndi zotsutsana zingapo, makamaka kwa magulu omwe nzika zomwe zapulumuka myocardial infaration, zimadwala matenda am'mitsempha kapena magazi. Kumwa mankhwalawa kungayambitse kuwoneka ngati malungo, kuyabwa, ming'oma, chizungulire, koma ngati mutsatira malangizowo, ndiye kuti zotsatira zotere sizingachitike.

Kuunika kwa osewera atatha kumwa mankhwalawa, monga lamulo, ndi kwabwino. Zotsatira zoyipa, ngakhale zimawonetsedwa, ndizosowa kwambiri. Popeza izi zimachitika makamaka ndi akatswiri othamanga, amakhala olimba mtima pazinthu zotere ndipo amatsatira mosamalitsa malangizo. Zotsatira zoyipa zikafika, panali vuto la othamanga. Ngati mugwiritsa ntchito moyenera komanso mwanzeru, mutha kupindula kokha: choyambirira, mankhwalawa amagwira ntchito, ndipo, kachiwiri, amawononga ndalama zochepa kuposa ma analogu opangidwa ndi makampani odziwika omwe amachita masewera othandizira.

Zotsatira za pharmacological

Agapurin ndi m'gulu la purines ndipo ali ndi antispasmodic (i.e. amatsitsa minofu yosalala). Chifukwa cha izi, zimapangitsa kuyenda kwam magazi ngakhale m'mitsempha yaing'ono kwambiri ndikuthandizira kusintha kwazomwe zimachitika m'magazi. Vasodilation yoyambitsidwa ndi Pentoxifylline imayambitsa kutsika kwa zotumphukira zamitsempha, kukwera kwa kugunda kwamphamvu ndi miniti ya mtima. Komabe, palibe kuwonjezeka kwa kugunda kwa mtima.

Njira yolepheretsa ya thrombosis imalumikizidwa ndi kulepheretsa kosasintha kwa phosphodiesterase, kuchuluka kwa cAMP m'mapulateleti, komanso kudziunjikira kwa ATP m'maselo ofiira a m'magazi.

Chosafunikanso ndichomwe chimapangitsa chikoka cha Agapurin pamitsempha yama coronary. Pentoxifylline imawonetsa mphamvu yovutikira ya antianginal chifukwa chakukula osati kokha kwa mitsempha ya mtima, komanso mapapu.

Mankhwala amatha kuonjezera kamvekedwe ka diaphragm ndi minyewa yam'mimba (minyewa yopuma).

Ngati matenda a occlusive am'munsi amatsika (kuthana ndi endarteritis kapena atherosclerosis), mankhwalawa, chifukwa cha antispasmodic ndi antiplatelet kanthu, amathetsa kukokana kwa usiku, kuwonjezera kuyenda, ndikuchepetsa ululu m'misempha ya ng'ombe pang'onopang'ono.

Mlingo ndi makonzedwe

Mapiritsi a Agapurin amatengedwa mukatha kudya, nthawi yomweyo masana, ndimadzi ambiri. Simungathe kutafuna mankhwalawo.

Mlingo woyambira wa Pentoxifylline ndi 200 mg katatu pa tsiku kwa masiku 7. Pankhani ya kuchepa kwambiri kwa kuthamanga kwa magazi, komanso zizindikiro za m'magazi kuchokera mu dongosolo la chimbudzi kapena dongosolo lamanjenje, mlingo umachepetsedwa mpaka 100 mg (wofanana ndi piritsi 1) katatu patsiku.

Pakukonza mankhwala, mlingo wa 100 mg umagwiritsidwa ntchito m'mawa, masana ndi madzulo. Pankhaniyi, mankhwalawa amatengedwa pafupipafupi kwa miyezi ingapo.

Mlingo wovomerezeka tsiku lililonse ndi 1200 mg.

Pachipatala cha creatinine choposa 400 mmol / l (kulephera kwaimpso kapena pachimake), mlingo wotengedwa umachepetsedwa ndi 30% kapena 50%.

Zizindikiro zochuluka

Ngati mubwereza mankhwala tsiku lililonse mobwerezabwereza, zizindikiro monga

Kutaya chikumbumtima.
Kuchepa kwa khungu.
Kutulutsa magazi kuchokera ku ziwiya za mucous membrane wam'mimba (kusanza, zofanana ndi "khofi malo").
Zovuta, limodzi ndi kutentha.
Areflexia.
Kuukira kwa tonic-clonic kulanda.
Kugona.
Tachycardia.
Chizungulire

Mankhwala alibe mankhwala enaake, chifukwa chake, mwa kuledzera kwa Agapurin, pharmacotherapy yodziwika bwino imachitika ndikuyang'anira ntchito zofunikira za thupi.

Kuyanjana kwa mankhwala osokoneza bongo

Pentoxifylline amatha kuthana ndi zotsatira zamankhwala omwe amakhudza njira zopangira magazi. Pakati pawo: anticoagulants osadziwika komanso mwachindunji, komanso thrombolytics. Mwachidule zotsatira zoyipa zitha kudziwika ndi kuphatikiza kwa Agapurin ndi antibacterial othandizira a cephalosporin (1-2 m'badwo). Pentoxifylline ndi osafunikanso kuphatikiza ndi valproates (zotumphukira za valproic acid).

Chifukwa cha zotsatira zake za pharmacodynamic, Agapurin amawonjezera mphamvu ya mankhwalawa monga: antihypertensive mankhwala, pakamwa hypoglycemic mankhwala ndi insulin.

Histamine receptor blocker Cimetidine amatha kuwonjezera kuchuluka kwa pentoxifylline mu seramu yamagazi. Izi zimatha kubweretsa zingapo zoyipa kapena zizindikiro za bongo.

Agapurin wokhala ndi xanthines sayeneranso kuphatikizidwa, chifukwa pharmacotherapy yotere imatha kubweretsa mawonekedwe awonetsero wa kusokonezeka kwamanjenje kwa wodwala.

Zotsatira zoyipa

Mitsempha yam'mimba: Kukodwa mwamphamvu, kugona tulo, chizungulire, nkhawa, kupweteka mutu.
Minofu yofewa (minyewa yamafuta amkati ndi khungu): redness (hyperemia) ya nkhope, kumva kuthinikizika kumtunda, kutupa, kuchuluka kwa misomali.
Kutupa kwam'mimba thirakiti: kuchulukitsa kwa zizindikiro za cholecystitis, hepatitis ya pakhungu, mkamwa youma, matumbo a m'matumbo, kuchepa kwa chilakolako cha chakudya.
Ziwalo zam'maso: kuwoneka kwa mawanga owoneka bwino kapena mozungulira pamaso pa maso, kuchepa kwa mawonekedwe owoneka.
Hematopoietic ziwalo ndi hemostasis dongosolo: kutsika kwa maselo ambiri, leukocytes, fibrinogen, magazi ochokera ku ziwiya za mucous nembanemba.
Thupi lawo siligwirizana za mitundu yapadera kapena yachedwa.
Zoipa zowonekera zasayansi pakuwunika kwa zamankhwala osokoneza bongo: kuchuluka kwa ALT, LDH, AST, alkaline phosphatase.

Zolemba za Agapurin

Trental 400 Pentoxifylline Rivo, Fleksital, Pentoxifylline-ICN, Pentoxifylline, Pentoxifylline-Teva, Pentoxifylline eka, Pentoxifylline, Escom, Pentoxifylline-PVD Radomin, Agapurin achigonjetse Pentomer, Ralofekt 300 Ralofekt, Trental, H Trenpental, Pentogeksal, Pentilin forte, Pentamone, Pentoxifylline, Arbiflex-100, Pentilin, Agapurin 600 retard, Arbiflex-400 Vazonit, Agapurin SR

Zolemba zaukadaulo wazachipatala

Agapurin ndi mankhwala osokoneza bongo a pentoxifylline.Mankhwalawa ndi a metabolites kuchokera ku gulu la xanthines, purines ndipo amathandizira kukonza ndikusintha ma microcirculation osiyanasiyana a mtima. Monga vasodilator wogwira, Agapurin amasintha kwambiri magazi m'magazi, amakulitsa m'mitsempha yamagazi, amachititsa minofu, ndipo amatha kuwonjezera kuchuluka kwa ATP m'maselo a thupi.

Kutulutsa Fomu

Mankhwalawa amapezeka piritsi ndi jekeseni, m'magulu osiyanasiyana, omwe amasonyezedwa pamafupa osiyanasiyana a mtima, kutengera kuopsa kwa matendawa. Monga lamulo, ngati matendawa apezeka kuti ndi akulu, jakisoni wa Agapurin amaperekedwa kudzera mwamitsempha kapena intramuscularly, kukonza mankhwalawa kapena kuchiza matenda opatsirana kumaphatikizapo kumwa mankhwalawo piritsi.

Njira yodzilowetsera - ma ampoules a ma milliliters asanu, asanu ndi awiri
Mapiritsi a milligram 100, mapiritsi 60 pamphongo
Mapiritsi - mamiligalamu 400 a mankhwala othandizira - mapiritsi 10 pachimake, matuza 2-10 pakunyamula koyambirira
Mapiritsi - ma milligram 600 a pentoxifylline, mapiritsi 10 pachimake, matuza awiri mpaka 10 pa paketi iliyonse
Agapurin retard - 400, ma milligram 600 a mankhwala othandizira, ali pachimake cha mapiritsi 10, m'matumba awiri a matuza

Zomwe zimapangidwira zimaphatikizapo zinthu izi:

Pentoxifylline (100, 400, 600 mg)
: Lactose monohydrate (lactose monohydrate, shuga mkaka)
Talcum ufa
Wowuma chimanga
Magnesium stearate (magnesium stearate, stearic acid)
Silicium dioxide colloidal (silicon dioxide colloidal)
Carlone sodium, glycerol (sodium carmellose)
Kubweza
Methylparaben (ochepa kuchuluka kwa methylparaben)
Gummi arabicum (acacia chingamu)
Titanium Dioxide
Microcrystalline mapadi

Mlingo ndi kasamalidwe ka Agapurin

Mapiritsi a Agapurin amatengedwa pakamwa pakudya, makamaka nthawi yomweyo. Mlingo woyambirira, monga lamulo, ndi 200 mg katatu patsiku. Odwala omwe akhala akuchita chithandizo kwa nthawi yayitali, komanso omwe ali ndi vuto lalikulu kwambiri loyipa kapena kupweteka kwam'mimba kapena kuchepa kwamitsempha yamagazi, amachepetsa mlingo wa 100 mg katatu patsiku. Mlingo wovomerezeka tsiku lililonse ndi 1200 mg.

Mapiritsi okhala ndi nthawi yayitali amapatsidwa 1 pc. kawiri kapena katatu patsiku.

Njira ya Agapurin imatha kuperekedwa kudzera mu intramuscularly, kudzera m'mitsempha kapena kudzera m'mitsempha. Njirayi ndiyovomerezeka m'malo a wodwala.

Mitsempha, mankhwalawa nthawi zambiri amathandizidwa ndi 100 mg (omwe amafanana ndi 1 ampoule), kusungunuka kwa 250-500 ml ya 5% dextrose solution kapena 0,9% sodium chloride yankho pakuwola kwa maola 1.5-3. Ngati Agapurin adalekerera bwino, mlingo umatha kuwirikiza, ndi 300 mg.

Patsiku loyamba, 100 mg ya Agapurin imayang'aniridwa kudzera m'mitsempha, ndikuwasungunula mu 20-50 ml ya sodium kolorayidi, ndiye 200-300 mg aliyense wosungunuka ndi 30-50 ml ya solvent. Kutalika kwa jakisoni ndi mphindi 10. Odwala omwe ali ndi vuto lalikulu la mitsempha ya chithokomiro amaletsedwa kupaka jekeseni ya chotupa cha carotid.

Intramuscularly, Agapurin amapatsidwa 100 mg kamodzi kapena kawiri pa tsiku.

Kusintha kwa mulingo wocheperako (pafupifupi 30-50%) kumafunikira anthu omwe ali osakwanira aimpso (omwe ali ndi CC yopitilira 400 mmol / l).

Migwirizano ndi magwiritsidwe akusungidwa

Ndikulimbikitsidwa kusunga Agapurin pouma, yotetezedwa ku dzuwa mwachindunji ndi malo ozizira kutentha: 15-25 ºº - mwanjira ya mapiritsi, 10-25 ºº - mwanjira yankho.

Moyo wa alumali wa mapiritsi a Agapurin ndi zaka 5, yankho lake ndi zaka zitatu.

Kodi mwapeza cholakwika m'mawuwo? Sankhani ndikusindikiza Ctrl + Lowani.

Kugwiritsa ntchito Agapurin Pakati Pathupi

Malinga ndi malangizo, kugwiritsa ntchito pakakhala pakati sikulimbikitsidwa. Komabe, muzochitika za kuchipatala, milandu sichachilendo pamene mayi wamtsogolo amatha kupatsidwa mankhwala okhala ndi pentoxifylline. Munthawi ya bere, zovuta zina zoyenda mozungulira zimatheka, ndipo zinthu izi ndizowopsa pakukula kwa mwana wosabadwayo. Zikatero, adotolo amabweretsa funso loti kuchuluka kwa mavuto kwa mayi ndikuwopseza mwana. Chimodzi mwazinthu zowopsa kwambiri ndi gestosis, yomwe imayamba yachiwiri chifukwa cha venous stagnation kapena kuvalidwa kwa capillaries. Mchitidwewo umayamba ndikutupa, kenako kukanika kwa impso kumachitika, mapuloteni amawoneka mkodzo, mutu komanso ngakhale kukokana. FPN imakhalanso yoopsa - kusowa kwa fetoplacental, limodzi ndi ma spasms a mtima dongosolo la placenta ndi fetal hypoxia.
Gwiritsani ntchito panthawi yomwe muli ndi pakati pazovomerezeka ngati izi sizovomerezeka, komanso zofunikira, chifukwa mankhwalawa amatha kubwezeretsanso kusintha kwachilendo komanso kuthamanga kwa magazi. Kupereka mankhwala kumathandizira kuyendetsa magazi, kuchepetsa chiopsezo cha kupatsidwa zinthu za m'magazi (gluing), komanso kukonza magazi m'thupi. Vasodilation imalola magazi kukhala ndi minyewa yambiri ndikuchepetsa chiwopsezo cha fetal hypoxia. Kusankhidwa koteroko kumakhala koyenera, popeza maubwino a mayi ndi mwana amakula kwambiri zotsatira zoyipa za pentoxifylline.

Amalembedwa mosamala kwa amayi apakati omwe ali ndi mbiri ya UBI kapena chilonda cha duodenal, komanso omwe ali ndi magazi ochepa. Komanso, mankhwalawa amayenera kusiyidwa kumapeto kwa nthawi yoletsa kubereka. Mwambiri, Agapurin, monga mawonekedwe ake, amagwiritsidwa ntchito kwambiri pachipatala, kuchita zinthu zothandizira kuphatikiza ngati vasodilator wopatsa yemwe alibe chiyambi pakukula kwa fetal.

Mlingo ndi makonzedwe

Mlingo komanso muyezo wa mankhwalawa zimatengera kuperewera kwa matendawa komanso kuopsa kwa matendawa. Sipangakhale kuyikidwa konse konse m'lingaliro ili, komabe, pali malingaliro onse omwe amaperekedwa pansipa.

Mlingo ndi makonzedwe kutengera mitundu:

Fomu yamapiritsi. Mankhwalawa amatengedwa mutatha kudya, imwani piritsi popanda kutafuna, ndimadzimadzi ambiri (madzi)
Kulandila kuyenera kutsimikiziridwa ndi mtundu - piritsi likuledzera nthawi yomweyo ya tsiku
Mlingo woyambirira wa mankhwalawa ndi mamiligalamu 200 katatu patsiku
Ndi chiwonetsero cha mavuto, mankhwalawo amachepetsa chimodzimodzi monga regimen - 100 mg 2 nthawi komanso kugogoda. Pambuyo pa masiku 3-4, 100 mg imatha kumwa katatu patsiku
Mlingo wambiri watsiku ndi tsiku sayenera kupitirira mamililita 1200
Agapurin retard (mankhwala osakhalitsa) amatengedwa nthawi zambiri - nthawi 1-2 patsiku, kutengera mawonekedwe ake
Jekeseni imatha kutumikiridwa kudzera m'mitsempha kapena m'mitsempha:

Intramuscularly 100mg 102 nthawi tsiku lililonse popanda zosungunulira
Mothandizidwa - mankhwala amaphatikizidwa mu 250 kapena 500 ml ya sodium kolorayidi (monga njira yothetsera shuga - 5%). Njira yoyendetsera ndiyosayenda, osati apamwamba kuposa mamililita 150 pa ola limodzi. Mulingo wambiri watsiku ndi tsiku wa jakisoni wa Agapurin ndi ma ampoules awiri
Intraarterial kukokana - the ampoule amasungunuka mu 20 kapena 50 silt wa sodium chloride. Kuyamba kuyenera kukhala kosakwiya, kokwanira - mphindi 10. Pazipita tsiku mlingo 3 ampoules patsiku
Kutalika kwa chithandizo kumatengera chithunzi cha matenda ndi momwe achire angathere.

Malangizowa siabodza ndipo sangaganize kuti ndi lingaliro lachindunji pakugwiritsira ntchito mankhwalawa. Njira ntchito ndi kumwa mankhwala ndi dokotala mogwirizana ndi momwe wodwalayo alili komanso zikuwonetsa kuti wapezeka ndi mtima.

Kuchita ndi mankhwala ena

Kugwiritsa ntchito mankhwala osokoneza bongo chifukwa cha pharmacodynamics, mankhwalawa amatha kuyambitsa mankhwala aliwonse a antihypertensive, vasodilators, ma amine opanga (ganglion blockers). Chifukwa chake, mankhwalawa omwe amatha kuthana ndimagazi, ndikumamwa, kuwonjezera mphamvu zawo, ndikuyambitsa kuyanjana. Ma anticoagulants ochokera mwachindunji kapena osagwiritsidwa ntchito, mankhwala okhala ndi valproic acid, mitundu ina ya mankhwala opatsirana, makamaka cephalosporin osakanikirana ndi Agapurin angayambitse matenda osafunikira, izi ziyenera kuganiziridwa popereka mankhwala.

Mogwirizana ndi mankhwala ena:

Kuchuluka kwa magwiridwe antchito:

Kuphatikiza ndi thrombolytics
Ndi munthawi yomweyo mankhwala a antihypertensive mankhwala
Kuphatikiza ndi insulin kapena mankhwala ena a hypoglycemic mu mawonekedwe a piritsi
Ndi munthawi yomweyo makonzedwe a cephalosporins (cefoperazone, cefamandol, cefotetan)
Kuphatikiza ndi PVC - valproate (Depakin, Valparin, Konvuleks)

Fotokozerani mosamala ndi mankhwalawa:

Kuphatikiza ndi cimetidine, kuchuluka kwa yogwira mankhwala (pentoxifylline) m'madzi a m'magazi kungachulukane
The munthawi yomweyo makonzedwe a Agapurin ndi ena purines, xanthines akhoza kubweretsa zoyipa kuchokera mantha dongosolo (kuchuluka mantha excitability)
Mothandizidwa ndi mankhwala othana ndi mphumu (theophylline), mavuto obwera ndi phosphodiesterase inhibitors atha kukhala - nseru, kutsekula m'mimba, kupweteka kwa mutu, ma epileptoid mayiko

Popeza Agapurin amayambitsa mwachangu machitidwe a mankhwala omwe amapangidwa kuti achepetse kuthamanga kwa magazi, ndikofunikira kuonetsetsa kuti kuphatikiza kwa mankhwalawa sikumapangitsa kuti magazi azikhala ochepa. Kuphatikiza apo, kugwiritsidwa ntchito kwa nthawi yayitali kwa xanthines kumatha kuyambitsa zotsatira za mankhwala a hypoglycemic, komanso insulin, pazinthu zotere, kukonzanso chithandizo cha antidiabetic ndikuwunika pafupipafupi kuchuluka kwa shuga m'magazi kumalimbikitsidwa kupewa hypoglycemia. Ndi makonzedwe apakati pa Agapurin ndi thrombolytics, PTV (nthawi ya prothrombin) ndi IPT (prothrombin index) iyenera kuwerengedwa pafupipafupi kuteteza chiwopsezo cha kukha mwazi ndi kukha mwazi.

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