Glucophage Long 500 pakuchepetsa thupi - malangizo ogwiritsira ntchito ndi mawonekedwe, mawonekedwe omasulira ndi mtengo

Glucophage Long: Malangizo ogwiritsira ntchito ndi kuwunikira

Dzina lachi Latin: Glucophage lalitali

Code ya ATX: A10BA02

Chithandizo chogwira: Metformin (Metformin)

Wopanga: Merck, KGaA (Germany), Merck Sante, s.a.s. (France)

Kusintha kufotokozera ndi chithunzi: 10.23.2018

Mitengo muma pharmacies: kuchokera ku 205 ma ruble.

Glucophage Long - mankhwala omwe ali ndi hypoglycemic effect.

Kutulutsa mawonekedwe ndi kapangidwe kake

Mlingo wa kutulutsidwa kwa Glucofage Long - mapiritsi olimbikitsidwa: kapangidwe kake, biconvex, pafupifupi koyera kapena koyera, mbali imodzi yolemba "500", "750" kapena "1000" (kutengera mlingo), 750 ndi 1000 mg aliyense mbali inayi, Merck yolemba (ma PC 7 m'matumba, matuza 4 kapena 8 pamatoni a makatoni, ma PC 10. M'matumba, matuza atatu kapena 6 pamatumba a makatoni, ma PC 15 m'matumba, pamatumba awiri kapena anayi). chithuza, pa chithuza ndi bokosi lamatoni kuti muteteze kusasokoneza kokhala ndi chizindikiro "M".

Piritsi limodzi:

• yogwira mankhwala: metformin hydrochloride - 500, 750 kapena 1000 mg,
• othandizira (500/750/1000 mg): sodium carmellose - 50 / 37.5 / 50 mg, cellcrystalline cellulose - 102 //0 mg, hypromellose 2208 - 358 / 294.24 / 392.3 mg, hypromellose 2910 - 10/0/0 mg, magnesium stearate - 3.5 / 5.3 / 7 mg.

Mankhwala

Glucophage Long ali m'gulu la mankhwala otuluka m'kamwa kuchokera pagulu la Biguanide, omwe amachepetsa kuchuluka kwa shuga m'magazi a postalandial plasma.

Metformin simalimbikitsa kubisirana kwa insulini ndipo sikupangitsa kuti hypoglycemia itukuke. Zimawonjezera chidwi cha zotumphukira za insulin zolandilira komanso kugwiritsa ntchito shuga ndimaselo. Chifukwa cha kuletsa kwa glycogenolysis ndi gluconeogeneis, amachepetsa kupanga shuga ndi chiwindi. Kuchepetsa mayamwidwe m'matumbo.

Metformin, wogwiritsa ntchito glycogen synthetase, amalimbikitsa kapangidwe ka glycogen. Kuchulukitsa kuchuluka kwa mayendedwe amtundu uliwonse wa ma membrane glucose.

Thupi limakhala ndi phindu pa metabolidi ya lipid: otsika triglycerides, otsika kachulukidwe lipoproteins (LDL) ndi cholesterol yathunthu.

Pazithandizo, wodwala amakhala wodekha kapena wocheperako.

Pharmacokinetics

Mayamwidwe a metformin pambuyo mkamwa makonzedwe a Glucofage Long poyerekeza ndi mapiritsi ndi ochiritsira amasulidwe pang'onopang'ono. T_max (nthawi yoti mupeze kuchuluka kwa zinthuzo) mutatenga 500 mg ndi maola 7 (mutatenga 1500 mg T_max ikhoza kusintha pakati pa maola 4-12), T_max mapiritsi okhala ndi kutulutsidwa kwapadera - maola 2,5.

Mofanana, C_max (pazipita kuchuluka kwa chinthu) ndi AUC (dera lozunguliridwa ndi nthawi yayitali) siziwonjezeka malinga ndi mlingo. Mlingo umodzi wa 2000 mg wa metformin mu mawonekedwe a mapiritsi otulutsidwa, AUC ndi ofanana ndi pambuyo pa 1000 mg ya metformin kawiri patsiku mawonekedwe a mapiritsi omasulidwa mwachizolowezi.

Mwa odwala ena, kusinthasintha mu C_max ndi AUC pankhani yotenga Glucofage Long ndiwofanana ndi omwe amatenga mapiritsi okhala ndi mbiri yabwino yotulutsidwa.

Mayamwidwe a metformin kuchokera pamapiritsi a nthawi yayitali sizimadalira chakudya.

Kumangika kwa zinthuzo m'mapuloteni a plasma sikungatheke. C_max m'magazi m'munsi mwa plasma C_max ndipo imafikiridwa pafupifupi nthawi yomweyo. Pakati V_d (voliyumu yogawa) ili mulingo kuchokera pa malita 63 mpaka 276.

Kuchulukana kwa metformin ndi Mlingo wambiri mpaka 2000 mg patsiku sikuwonetsedwa.

Palibe ma metabolites omwe anapezeka.

T_1/2 (kuchotsa theka-moyo) pambuyo pakamwa pakamwa ndi pafupifupi maola 6.5. Imafufutidwa ndi impso zosasinthika. Kuwonekera kwamphumo kwa chinthu ndi> 400 ml / min (metformin imachotsedwa chifukwa cha katulutsidwe katulutsidwe komanso kusefedwa kwa glomerular).

Chilolezo cha Metformin mwa odwala omwe ali ndi vuto la impso amachepetsa mogwirizana ndi kulengedwa kwa creatinine, T_1/2 pagululi la odwala limachulukitsa, lomwe lingayambitse kuchuluka kwa plasma.

Contraindication

kuwonongeka kwa impso kapena kulephera kwa aimpso (kulengedwa kwa creatinine kwa 10% - pafupipafupi,> 1% ndi 0,1% ndi 0,01% ndi 5 mmol / l, kuchuluka kwa lactate / pyruvate ndikukulitsa kusiyana kwa anionic.) Ngati lactic acidosis ikukayikiridwa Glucofage Long yathetsedwa nthawi yomweyo.

Mankhwala ayenera kusokonezedwa maola 48 asanafike pokonzekera opareshoni. Kuyambiranso kwa mankhwalawa kumatha kuchitika patatha maola 48, pokhapokha pakuwunikira, ntchito yaimpso inadziwika kuti ndi yachilendo.

Asanayambe chithandizo komanso mtsogolomo mtsogolo, kuvomerezedwa kwa creatinine kuyenera kutsimikiziridwa: pakalibe kusokonezeka, osachepera 1 pachaka, odwala okalamba, komanso odwala omwe amapezeka ndi creatinine chilolezo chotsika, kuyambira 2 mpaka 4 pachaka. Ndi creatinine chilolezo chochepera 45 ml / min, kugwiritsa ntchito Glucofage Long ndizotsutsana.

Pamaso pa vuto la impso lomwe lingayambike motsutsana ndi maziko ophatikizira ndi antihypertensive mankhwala, okodzetsa kapena osagwiritsa ntchito mankhwala a anti-kutupa odwala okalamba, chisamaliro chapadera chikuyenera kuthandizidwa.

Chiwopsezo chachikulu cha hypoxia ndi kulephera kwaimpso chimawonedwa mwa odwala omwe ali ndi vuto la mtima. Gulu ili la odwala likufunika kuwunika mtima ndi ntchito ya impso.

Odwala akulangizidwa kuti apitirize kudya zakudya zomwe zimapezeka mu chakudya tsiku lonse.

Ndi onenepa kwambiri, muyenera kupitiriza kutsatira zakudya zama hypocaloric (koma osachepera 1000 kcal patsiku). Komanso, odwala ayenera kuchita masewera olimbitsa thupi pafupipafupi.

Matenda opatsirana aliwonse (matenda a kwamkodzo ndi matenda amtundu wa kupuma) ndi chithandizo ziyenera kudziwitsidwa kwa dokotala.

Kuti muthane ndi matenda ashuga, kuyeserera kwa ma labotale kumayenera kuchitidwa pafupipafupi.

Ndi monotherapy, Glucophage Long siyimayambitsa hypoglycemia, koma kusamala kumalimbikitsidwa akagwiritsidwa ntchito limodzi ndi insulin kapena othandizira ena pakamwa. Zizindikiro zazikulu za hypoglycemia: kuchuluka thukuta, kufooka, chizungulire, kupweteka mutu, palpitations, kusokonezeka kwa chidwi kapena masomphenya.

Zosagwira ntchito za Glucofage Long zitha kupukusidwa kudzera m'matumbo osasinthika, zomwe sizikuwakhudza mankhwalawa othandizira.

Ndi mkhutu aimpso ntchito

• kuvulala impso ntchito (creatinine chilolezo zosakwana 60 ml / mphindi), zovuta pachimake ndi chiwopsezo aimpso ntchito (kuphatikizapo madzi m'thupi kwambiri / kutsegula m'mimba, kusanza mobwerezabwereza), matenda opatsirana, mantha: Glucofage Long is contraindicated,
• Kulephera kwa aimpso (creatinine chilolezo cha 45-59 ml / mphindi): mankhwalawa akuyenera kuchitika mosamala.

Kuyanjana kwa mankhwala osokoneza bongo

Kafukufuku wama radiology wogwiritsa ntchito ma iodine wokhala ndi ma radiopaque othandizira kuti alephere kugwira ntchito mwamphamvu kwa odwala omwe ali ndi matenda osokoneza bongo angayambitse kukula kwa lactic acidosis. Maola 48 asanafike phunziroli, Glucophage Long iyenera kuletsedwa. Ngati ntchito ya impso idapezeka kuti yakhala yachilendo pakubwereza, chithandizo chitha kuyambiranso pambuyo pa maola 48.

Mukamamwa ethanol, mwayi wa lactic acidosis panthawi yoledzera mowa umachulukirachulukira, makamaka ndi kulephera kwa chiwindi, komanso ngati mukudya kwambiri zakudya zopatsa mphamvu. Mankhwala okhala ndi ethanol sayenera kugwiritsidwa ntchito pakumwa.

Kuphatikiza kosamala:

• okodzetsa, danazol, beta₂--adrenomimetics, chlorpromazine (Mlingo kuchokera pa 100 mg patsiku), mankhwala osokoneza bongo a hyperglycemic (makamaka, glucocorticosteroids ndi tetracosactides othandizira apakhungu / a systemic): makamaka kuyang'anira kuchuluka kwa shuga wamagazi kungafunike, makamaka kumayambiriro kwa chithandizo, Ngati ndi kotheka, munthawi ya chithandizo, muyezo wa Glucofage Long ungasinthidwe,
• "Loop" okodzetsa: kukulitsa kwa lactic acidosis (komwe kumayenderana ndi kugwira ntchito kwa aimpso),
• zotumphukira za sulfonylureas, insulin, acarbose, salicylates: kukula kwa hypoglycemia,
• nifedipine: kuchuluka mayamwidwe ndi C_max metformin
• kupita ku chisel: kuchuluka kwa plasma ndende ya metformin m'magazi (kuchuluka kwa AUC popanda kuchuluka kwakukulu kwa C_max),
• mankhwala a cationic (quinine, triamteren, ranitidine, quinidine, amiloride, digoxin, procainamide, morphine, vancomycin ndi trimethoprim), omwe amatsekeredwa mu renal tubules: mpikisano ndi metformin yama tubular transport system, omwe ungapangitse kuwonjezereka kwa C yake_max.

Zofanizira za Long Glucophage ndi: Fomu, Metformin, Metadiene, Fomu Pliva, Diasfor, Bagomet, Glformin, Glucofage, Sofamet ndi ena.

Mfundo zoyenera kuchita ndi mapiritsi

Pharmacological zotsatira za yogwira pophika - metformin, umalimbana kuchepetsa kuchuluka kwa shuga m'thupi la munthu, womwe umatha kuchuluka pambuyo chakudya.

Njira yolerera yodutsa m'magazi nditatha kudya ndiyachilengedwe ngakhale kwa munthu aliyense wathanzi, ndipo kapamba amatenga nawo mbali nthawi zonse, ndikupereka kapangidwe kake ka insulin. Cholinga cha mahormoni ndicho kuphwanya shuga kukhala mafuta.

Mankhwalawa ali ndi vuto limodzi labwino - limapereka kuchepa kwa thupi osati kokha kwa matenda a shuga a 2, komanso mwa anthu athanzi omwe amamwa.

Ndiye, ndi zotsatirapo ziti zomwe mungayembekezere kuchokera kwa mankhwala omwe akhala akuchita kwa nthawi yayitali? Kutenga mapiritsi kumapereka izi:

• Kukhazikika kwa kagayidwe ka lipid m'thupi.
• Dziwani kuwonongeka kwa chakudya cham'mimba komanso kusintha kwawo kukhala minofu ya adipose.
• Matenda a cholesterol m'mwazi.
• Chepetsani ndi kukhazikika shuga pamlingo woyenera.
• Kuwongolera magwiridwe antchito a kapamba.
• Kuchepetsa chilala, kusowa chidwi mu zakudya zotsekemera.

Pakachepetsa kuchepa kwa shuga, mamolekyulu amtunduwu amapatsidwa minyewa yomweyo. Amakhala komweko, shuga "imatha", mafuta makutidwe ndi michere amawonekera, kuyamwa kwa chakudya kumalepheretsa.

Zotsatira zake, izi zimatsogolera kuti kuchepa kwa njala kumapezeka, maselo amafuta samadziunjikanso, motero, samayikidwa m'malo osiyanasiyana a thupi.

Zizindikiro zogwiritsidwa ntchito

Chizindikiro chachikulu chogwiritsidwa ntchito ndi Glucofage Long 500 mg ndi chithandizo cha mtundu 2 wa shuga, ngati odwala alibe chithandizo chamankhwala chofunikira.

Mwambiri, nthawi zambiri mankhwalawa amalimbikitsidwa kwa odwala omwe, motsutsana ndi matenda awo osakhazikika, amakhalanso ndi kunenepa kwambiri. Mapiritsi amatha kutsimikiziridwa ngati njira yodziwira chithandizo, ndiye kuti ndi njira yokhayo.

Kapenanso amaikidwa m'gulu la mankhwalawo, lomwe limaphatikizaponso mankhwala ena a hypoglycemic a pakamwa, kapena insulin.

Ndemanga za odwala zimawonetsa kugwira ntchito kwa mankhwalawa. Amazindikira kuti mankhwalawa alidi ndi tanthauzo, chilimbikitso chimachepetsa, ndipo zolakalaka za maswiti zimatha. Ponena za kuchepetsa shuga, njirayi imachitika pang'onopang'ono, ndipo glucose imakhazikika pamlingo wofunikira pakapita nthawi.

Mutha kugula mankhwala okhala nthawi yayitali mukam'pangira mankhwala, ogulitsa mankhwala osokoneza bongo kapena m'malo ogulitsira apadera.

Mtengo wa Glucofage Long 500 mg (phukusi la mapiritsi 60) ndi pafupifupi ma ruble 550.

Malangizo ogwiritsira ntchito

Musanapitilize mwachindunji ndi malangizo ogwiritsira ntchito mankhwalawa, ayenera kukumbukiranso. Ngakhale kuti mankhwalawa athandiza anthu ambiri kuchotsa mapaundi owonjezera, simuyenera kuchita nawo zodziyimira nokha.

Mankhwala amtunduwu amapangidwira zochizira matenda a shuga, koma osati kuwonda. Chifukwa chake, ngati mankhwalawa adathandizira kuchepetsa thupi - izi ndi zotsatira zoyipa, koma osatinso zina.

Mankhwala okhala nthawi yayitali akulimbikitsidwa kuti amwe pakamwa. Mapiritsiwo ayenera kuti amezedwa lonse, simungathe kutafuna mankhwalawo, kapena kukukuta m'njira ina iliyonse. Mlingowo umaperekedwa payekhapayekha, ndipo zimatengera kuchuluka kwa shuga m'magazi.

Zomwe ntchito mankhwalawa:

• Monga lamulo, Mlingo wokhazikika ndi piritsi limodzi la 500 mg kamodzi patsiku chakudya chamadzulo.
• Ngati wodwalayo wasamutsidwa kuchokera ku Glucofage nthawi zonse, Mlingo uyenera kukhala wofanana ndi mlingo wa Glucofage wa tsiku ndi tsiku.
• Kutengera mphamvu zakuchepa kwa shuga m'magazi, mulingo wa mankhwalawa umakulitsidwa pang'onopang'ono ndi 500 mg pazokwera tsiku lililonse.
• Mlingo wambiri ndi kumwa mapiritsi 4 patsiku chakudya chamadzulo.

Mankhwala a glucophage ayenera kumwedwa tsiku lililonse, simungathe kupanga pakati pakulandila kwake. Ngati wodwalayo amasiya mankhwalawo payekha, kapena sangathe kumwa chifukwa chilichonse, ndikofunikira kudziwitsa dokotala.

Chofunikira: ngati mankhwalawo adaphonya, ndiye kuti mulingo wotsatira umatengedwa mwachizolowezi, simungamwe mapiritsi awiri nthawi imodzi.

Mitu ya mankhwalawa

Monga tafotokozera pamwambapa, mankhwala ochizira matenda ashuga athandiza odwala ambiri, koma mndandanda waukulu wokhudza zotsutsana sikuti nthawi zonse umapangitsa kuti aperekedwe munthawi inayake.

Mothandizidwa ndi izi, adotolo angalimbikitse mankhwala omwewo kuti athandizane ndi kuchuluka kwa shuga m'magazi. Ganizirani mapiritsi ofala kwambiri komanso othandiza kuti muchepetse shuga.

Bagomet - mankhwala ochizira matenda a shuga a mellitus, omwe amaphatikizapo zinthu ziwiri zogwira ntchito nthawi imodzi: metformin ndi glibenclamide. Mapiritsi amalembedwa kuti athandize odwala matenda ashuga ngati wodwalayo alibe chizolowezi chokhala ndi matenda a shuga a 2. Mtengo wa mankhwalawo ndi pafupifupi ma ruble 250.

1. Gliminfor - mankhwala omwe amathandiza kuchepetsa kuchuluka kwa shuga m'magazi, ali m'gulu la Biguanides. Imakhala ndi zotsutsana zambiri komanso zoyipa, mlingo umayikidwa payekhapayekha. Mtengo wapakati ndi ma ruble 300.
2. Metfogamm 500 mg - mankhwala ochizira matenda a shuga, amapezeka mu mawonekedwe am'mapiritsi a pakamwa. Mankhwala ndi a gulu la Biguanides, kumawonjezera chiwopsezo cha minofu yofewa kwa shuga, kutsitsa thupi. Mtengo m'dera la 600-700 rubles.

Pomaliza, ziyenera kunenedwa kuti nthawi zambiri, kuwunika kwa Glucophage Long kunali kwabwino. Koma kuti mukwaniritse zofunikira pakuthandizira, muyenera kusankha mlingo woyenera, ndipo izi zitha kuchitidwa ndi dokotala okha.

Ndi mankhwala ati omwe mumamwa kuti muthane ndi matenda ashuga? Kodi Glucophage adakulimbikitsani, ndipo zidachitika bwanji? Gawani ndemanga zanu kuti muwonjezere ndemanga ndi malingaliro enieni.

Zotsatira zoyipa

Odwala ambiri omwe amatha kulipira bwino shuga ndi metformin amakakamizidwa kusiya milungu iwiri yoyambirira. Kwa izi amakakamizidwa ndi kupukusa m'mimba, zomwe zimakhala zotsatira zoyipa za mankhwalawo.Chiwopsezo chawo chimatha kuchepetsedwa ndikuwonjezera mlingo pang'onopang'ono, kumwa metformin nthawi yomweyo ndi chakudya komanso madzulo okha. Malinga ndi ndemanga, Zizindikiro zosasangalatsa pang'onopang'ono zimafooka ndipo pofika mwezi woyamba wa chithandizo nthawi zambiri zimatha.

Ngati zotupa zimasokoneza moyo wabwinobwino kapena kupitiliza kwa nthawi yayitali, akatswiri a ma endocrinologists amalimbikitsa kutenga glucophage yayitali kapena mawonekedwe ake. Mu theka la milandu, kusintha kwa mankhwala kumayendera limodzi ndi kutha kapena kufooka kwa zotsatira zoyipa.

Mndandanda ndi pafupipafupi (%%) zamatumbo zomwe zingachitike:

Malangizo ena amatcha zotsalira zoyipa za Glucofage ndizosowa kwambiri, malinga ndi wopanga, osakwana 0.01% odwala amakumana nawo:

• Thupi lawo siligwirizana nthawi zambiri limafotokozedwa mtundu wa kuyabwa ndi urticaria,
• kusokonezeka kwa chiwindi, kukula kwa michere ya chiwindi. Zotsatira zoyipazi nthawi zambiri sizifunikira chithandizo ndipo zimazimiririka zokha ukachoka kwa Glucofage Long,
• Vitamini B12 akusowa kwa nthawi yayitali,
• lactic acidosis imachitika nthawi zambiri ndi kulephera kwa aimpso, komwe kumayambitsa kukodza kwa metformin. Kuopsa kwa lactic acidosis kumachulukitsidwa ndi hypoxia, mowa, kusala kudya kwanthawi yayitali.

Kuphatikizika kwa mankhwalawa, mawonekedwe a kumasulidwa, kusungidwa ndi kugulitsa zinthu

Mankhwala amapangidwa ndi makampani azachipatala okha mwa mawonekedwe a piritsi.

Kunja, piritsi ili ndi mawonekedwe osinthika, mbali imodzi momwe amalembedwa 500 mg, zomwe zikutanthauza kuti zomwe zimapangidwa ndi chinthu chachikulu, kumbuyo ndiko kulembedwa dzina la wopanga.

Kuphatikiza pa ntchito yogwira, mapiritsiwa amaphatikizanso mankhwala othandizira.

Zotsatirazi zimagwira gawo lothandiza ku Glucofage Long 500:

• hypopellose,
• magnesium wakuba,
• povidone
• carmellose sodium,
• ma cellulose pama microcrystals.

Mankhwalawa amagwiritsidwa ntchito makamaka pa matenda a shuga a 2. Pozindikira izi, adathandizira odwala ambiri kuchepetsa misempha ya m'magazi awo mwa kusintha mtundu wa shuga m'magulu awo. Komanso mankhwalawa amathandizira pakuchepetsa thupi la wodwalayo, ndipo vutoli limapezeka kawirikawiri kwa odwala matenda a shuga.

Dziwani kuti chidacho chili ndi ndemanga zabwino, zomwe zikuwonetsa kuti si mankhwala othandizirana kwambiri, komanso amavulaza thupi. Ndemanga za mankhwalawa zimawonetsa kuti zotsatira zabwino za kumwa mankhwalawa zimapambana kwambiri pakuwonekera kwa zovuta zoyipa ndikupangitsa kuvulaza thupi.

Pharmodynamics ndi pharmacokinetics a mankhwalawa

Ngati mumazolowera malangizo omwe mungagwiritse ntchito mankhwalawa mwatsatanetsatane, zimamveka bwino za kugwiritsa ntchito mankhwalawa, komanso momwe zimachitikira thupi la munthu.

Kupanga kwakukulu kwa zamankhwala kwa zinthu zomwe zili ndi glucophage kutalika 500 ndikofunikira kuti muchepetse kuchuluka kwa shuga m'magazi a anthu.

Metformin, yomwe ndi gawo la mankhwalawa, satha kulimbikitsa kupanga insulin yowonjezera ndi maselo a beta. Pachifukwa ichi, kumwa mankhwalawa sikuti kumayambitsa kukula kwa thupi mthupi. Kuchita kwa chigawo chogwira ntchito ndikufuna kuchititsa zolandilira zama cell zomwe zimadalira insulin.

Pambuyo pakutenga Glucofage Long 500, kuwonjezeka kwa chidwi cha maselo a cell kupita ku insulin kumawonedwa, zomwe zikuwonjezera kuwonjezeka kwa kugwiritsidwa ntchito kwa glucose kuchokera m'madzi a m'magazi.

Kuphatikiza apo, pali kuchepa kwakukulu kwa kuchuluka kwa glucose wopangidwa ndi chiwindi maselo chifukwa cha kuyambitsa kwazomwe zimalepheretsa glycogenolysis ndi gluconeogenesis.

Metformin, yomwe ndi gawo la miyala, imapangitsa kuchepa kwa glucose kuchokera ku lumen ya m'mimba ndi maselo a khoma lamatumbo. Zomwe zimachepetsa kudya kwa mafuta m'magazi am'magazi. Izi zimachepetsa kuchuluka kwa chakudya chamafuta m'thupi.

Metformin imayendetsa njira zomwe zimayang'anira kupanga glycogen. Kutsegula kumachitika chifukwa cha metformin pa glycogen synthetase.

Kulowa kwa gawo logwira ntchito mthupi kumakulitsa mphamvu ya transporter yamtundu uliwonse.

Odwala ambiri omwe amatenga Glucofage Long amawonetsa kuti mankhwalawo adawathandiza kuti azichita shuga.

Kuphatikiza apo, chidachi chimalimbikitsa kuchepa thupi, chomwe ndichofunikira pakuchiritsa matenda a shuga.

Kuphatikiza apo, mankhwalawa amathandizira:

• kusintha kwa kagayidwe kachakudya njira,
• sinthani magawikidwe amthupi omwe amalowa mthupi ndi chakudya,
• Matenda a masanjidwe opanga insulin, chifukwa chomwe kuchuluka kwa mafuta amachepetsa,
• magazi cholesterol magazi.

Pothandizira izi, kuwunika kwa wodwala kumveka, mwachitsanzo, kuti, ndimamwa kapena kumwa Glucofage ndipo monga chotulukapo, kulemera kwanga kwa thupi kunabwezeretsa.

Mukamamwa Glucofage, pamakhala kuchepa kwa chilimbikitso, komwe kumachepetsa kuchuluka kwa mafuta m'thupi.

Kuchepa kwa njala kumathandizira kuti wodwalayo akhale ndi shuga.

Zotsatira zoyipa ndi kuyanjana ndi mankhwala ena

Makhalidwe abwino omwe Glucophage Long 500 ali nawo afotokozedwa kale pamwambapa.

Tsopano muyenera kufotokozera zovuta zomwe mankhwalawa atha kukhala nazo, komanso pazomwe zingakhale bwino kukana chithandizo ndi mankhwalawa.

Chifukwa chake, ndikofunika kumwa mankhwalawa:

• Nthawi yokhala ndi pakati ya azimayi, komanso nthawi yoti mayi ayamwe kuyamwa,
• kumwa kwambiri mowa,
• pakakhala zovuta ndi chiwindi.
• wodwala matenda ashuga
• ndi mavuto pokodza, komwe kumalumikizidwa ndi matenda a impso,
• pambuyo pathupi lamatumbo,
• pakakhala mavuto ndi mtima
• chododometsa kapena chochita pambuyo pake.

Munthawi zonsezi, ndibwino kukana chithandizo ndi mankhwalawa. Nthawi yomweyo, osagwiritsanso ntchito fanizo la mankhwalawa. Mavuto azinthu zomwe zimagwira mthupi pazinthu zomwe zili pamwambazi zimatha kuvulaza thanzi la munthu.

Inde, pali milandu yambiri pomwe mankhwala amathandizadi wodwala, koma palinso umboni kuti ungakhale wovulaza thanzi.

Makamaka, izi zimachitika m'mikhalidwe yomwe odwala samanyalanyaza malangizo a dokotala ndikuyamba kuthandizidwa pawokha.

Malangizo ogwiritsira ntchito mankhwalawa

Mphamvu zomwe zimathandizira kuti shuga asungidwe m'thupi la wodwalayo zimachitika pamene wodwalayo awona mosamala mlingo wa mankhwalawa komanso mankhwala ake.

Chifukwa chakuti mankhwalawa ali ndi phula lalitali, ndikokwanira kumwa mapiritsi kamodzi patsiku. Ndipo ndibwino kuzichita usiku.

Ngati mankhwalawa akuchitika molingana ndi malangizo ogwiritsira ntchito, ndiye kuti akuwonetsa - nthawi yakumwa mankhwalawa imatha masiku 10 mpaka 20. Pambuyo pake, kupumula kwakanthawi kumapangidwa kukhala kwa miyezi iwiri, ndipo atatha mankhwalawa amapitilira mogwirizana ndi malangizo a dokotala.

Dongosolo la chithandizo cha munthu payekha likhonza kuperekedwa kwa wodwala aliyense, kutengera zomwe zimachitika mthupi lake komanso kuunika kwake. Nthawi zambiri, mankhwalawa amathandizidwa ndi endocrinologist, yemwe amayambitsa kafukufuku wodwalayo pokhapokha atapereka njira yovomerezeka ya chithandizo.

Izi ndichifukwa choti aliyense wodwala matenda ashuga ali ndi zomwe ali ndi thupi. Mwanjira ina, m'chilengedwe mulibe chinthu chachiwiri chomwe chikhala ndi zofanana. Chifukwa chake, dongosolo la mankhwalawa limaperekedwa nthawi zonse ndi dokotala ndipo limasiyana ndi malingaliro omwe dokotala amapatsa wodwala wina.

Pankhani imeneyi, sizovuta kunena kuti simuyenera kumwa nokha mankhwalawo. Choyamba muyenera kufunsa katswiri wa endocrinologist.

Mankhwalawa, monga analogues, omwe amaphatikizanso Metformin Long, amapatsidwa mankhwala awa:

• lembani matenda ashuga 2 odwala
• Chithandizo cha matenda a shuga osagwiritsa ntchito mankhwala ena ochepetsa shuga (monotherapy),
• Kwa odwala azaka zosaposa 18, mankhwalawa amagwiritsidwa ntchito limodzi ndi insulin.
• pamene kudya komanso kuchita masewera olimbitsa thupi sizinathandize kuthana ndi shuga wambiri m'thupi,
• omwe ali ndi mavuto a kunenepa kwambiri.

Kutengera ndi chidziwitso ichi, zikuwonekeratu kuti mankhwalawa amagwiritsidwa ntchito makamaka kwa anthu odwala matenda ashuga, omwe, motsutsana ndi matenda omwe amapezeka kale, ali ndi zovuta zolemetsa.

Ndizofunikira kudziwa kuti malongosoledwe a mankhwala omwe amapezeka mu malangizo amafotokoza mwatsatanetsatane za momwe mankhwalawo amathandizira thupi komanso momwe zimakhalira ndi moyo

Wodwala aliyense ayenera kumwa mankhwala kwa nthawi yayitali malinga ndi kuchuluka kwa mankhwalawa omwe adokotala akumupangira komanso mogwirizana ndi dongosolo la mankhwalawa.

Kupenda kwamankhwala odwala ndi upangiri wachipatala

Mankhwala monga Glucofage Long 500 ndi mankhwala atsopano. Ndizoyenera kwa odwala omwe akufuna kuchita nthawi yayitali. Zimathandiza kuchepetsa bwino shuga ya wodwala. kusintha kukhathamira kwa shuga ndikupangitsa matenda a insulin kuphatikizika.

Koma awa ndi magawo akuluakulu a Glucophage Long 500 malangizo ogwiritsira ntchito akuwonetsanso kuti mankhwalawa amathandizira kwambiri ndi matenda a shuga komanso kunenepa kwambiri.

Koma, zowona, kuti amathandizadi wodwalayo, muyenera kufufuza kaye koyamba ndikuzindikira wodwalayo kuti adziwe. Izi zikuthandizira kutsimikizira njira yoyenera yothandizira, ndipo ngati kuli kotheka, kusankha mankhwala omwe amwe limodzi ndi mankhwalawa. Ndikofunikanso kupatula njira zomwe zingachitike kwa wodwala wina.

Ndizodziwikiratu kuti masiku ano pali fanizo lazinthu zochizira izi. Koma muyenera kuwasankha pokhapokha ngati mukufunsidwa ndi dokotala, simungasankhe nokha kuti ndi mtundu uti wa mankhwala omwe ali ndi mankhwala omwe ali bwino ndikusintha njira zomwe zilipo kale.

Zowunikira momwe akuti "Glucophage, ndidapulumutsidwa kwamuyaya" kapena "ndakhala ndikumwa mankhwala okhawo kwa zaka zambiri ndipo kulemera kwanga kuli kwambri", zimatha kukhala zowona, koma pokhapokha ngati wodwalayo ali ndi mavuto ndi mayamwidwe a shuga, mwanjira ina, matenda ashuga. Tengani mankhwalawo kuti muchepetse thupi, popanda kuyang'aniridwa ndi adokotala ndikosatheka.

Odwala ambiri amasangalala ndi mtengo wa mankhwalawo. Tiyenera kudziwa kuti mtengo wamalondawo ndiwothandiza kwambiri, motero odwala ambiri amatha kulipirira. Inde, pali zofananira za mankhwalawa, ndi adokotala okha omwe amayenera kuwalimbikitsa. Simuyenera kuyiyika pachiwopsezo ndikudziyimira nokha payokha, ndibwino kudalira katswiri.

Machitidwe a pharmacological a Glucophage akufotokozedwa mu kanema munkhaniyi.

Kugwirizana kwina ndi mankhwala ena

Kuti muchepetse mavuto omwe amabwera chifukwa cha Glucofage komanso kupewa mavuto, tikulimbikitsidwa kuti tisaphatikize kugwiritsa ntchito mapiritsi azakudya ndi mankhwala ena. Izi zikuphatikiza:

• mankhwala ochepetsa shuga, ngati sagwiritsidwa ntchito ndi dokotala,
• antipsychotic, antidepressants, zokupatsani mphamvu,
• mowa ndi mankhwala okhala nazo,
• zida zodulira
• antihypertensive (kuchepetsa-kukakamiza),
• mankhwala a cationic obisika mu aimpso tubules (Digoxin, Quinine, Quinidine, Morphine),
• zotumphukira za sulfonylureas, acarbose, salicylates (mwina kukula kwa hypoglycemia).

Kwa omwe mankhwalawo amatsutsana

Lactic acidosis ndi owopsa kwambiri. Chiwopsezo cha kufa kwa odwala matenda a shuga omwe ali ndi lactic acidosis ndi okwera kwambiri poyerekeza ndi zovuta zina za matenda ashuga. Metformin imachulukitsa kuchuluka kwa lactate m'thupi, chifukwa chake, mu contraindication ku kayendetsedwe kake, malangizowa akuphatikizapo zochitika zonse momwe chiopsezo cha lactic acidosis chikuwonjezeka. Awa ndi matenda aliwonse omwe amayambitsa hypoxia: mtima, impso ndi kupuma, kuchepa kwa magazi, kuchepa magazi chifukwa cha kusanza kapena kutsegula m'mimba, matenda opweteka kwambiri, makamaka kupuma komanso kwamikodzo thirakiti. Simungathe kutenga Glucophage Long ndi mafuta osakwanira a calorie (osakwana 1000 patsiku), uchidakwa, uchidakwa. Chonde dziwani kuti zochita za metformin zimatha kuposa tsiku limodzi, chifukwa chake simungathe kumwa piritsi m'mawa ndikumwa mowa madzulo.

Contraindication imaphatikizapo zochitika zilizonse zowopsa za anthu odwala matenda ashuga, pomwe sizingatheke kuyendetsa glycemia ndi mapiritsi, ndipo insulin yofunikira ndiyofunikira. Izi zonse ndi zovuta za matenda ashuga, osatengera gawo lawo, kuvulala kwambiri, kuwotcha, kukonzekera ndi kuchitapo kanthu mwadzidzidzi kwa opaleshoni yofunafuna opaleshoni yayikulu.

Glucophage Long aletsedwa kutenga ubwana, popeza wopanga sanachitepo maphunziro owonetsa chitetezo chake. Glucophage wabwinobwino amaloledwa kuchokera zaka 10.

Kugwiritsa Ntchito Mimba

Metformin imatha kulowa m'magazi a amayi kulowa m'magazi a mwana wosabadwayo. Komabe, sizimayambitsa kubadwa mwatsopano, sizimachulukitsa kufa kwa intrauterine. Pali malingaliro omwe mankhwalawa angayambitse kuyipa kwa mwana, koma sanapezeke mu maphunziro omwe analipo. Ku Russia, kubereka ndi kutsutsana kwathunthu kwa metformin. Poyerekeza ndi ndemanga, ngakhale mankhwalawo sanagwiritse ntchito molingana ndi mawonekedwe (kukonza ntchito yamchiberekero), amathetsedwa pakatha mimba. Ku Europe, metformin imavomerezeka chifukwa cha matenda ashuga.

Thupi limatha kudutsa mkaka wa m'mawere, ndipo kuchokera pamenepo limalowa m'magazi am'mimba ndi magazi a mwana. Ndi mkaka wa m`mawere, malangizowo amakupatsani mwayi kutenga Glucofage Long ndi fanizo la mankhwala mosamala pokhapokha ngati phindu lake limakhala lalikulu kwambiri kuposa vuto lomwe lingavulaze mwana. Izi zitha kukhala kukana kwambiri kwa insulini kuphatikiza kunenepa kwambiri, ndipo, motero, kufunika kwa Mlingo waukulu wa insulin. Kuchepetsa thupi pambuyo pobereka kapena kuchepetsa pang'ono glycemia, metformin nthawi zambiri sagwiritsidwa ntchito pa mkaka wa m`mawere.

Kuphatikiza ndi mankhwala ena

Zinthu zina zimatha kukhudza pharmacokinetics ya Glucophage Long, ndikuchulukitsa chiopsezo cha mavuto: