Zofananira za Traicor polimbana ndi cholesterol yayikulu

Tricor ndi imodzi mwamankhwala otsitsa lipid. omwe amatchedwanso fibrate.

Dzinali limachokera chifukwa chachikulu chogwira - fenofibrate. Amachokera ku fibroic acid.

Mothandizidwa ndi iye, kapangidwe ka apoprotein CIII kumachepetsedwa, komanso kukondoweza kwa lipoprotein lipase kumayamba, komwe kumakulitsa lipolysis ndikulimbikitsa kufutukuka kwaposachedwa kwa atherogenic lipoproteins kuchokera m'magazi omwe ali ndi triglycerides.

Ntchito yogwira ya fibroic acid ndi magawo ake amatha kuyambitsa PPARa ndikufulumizitsa kaphatikizidwe ka AI ndi AII apoptoreins.

Fenofibates imakonzanso catabolism ndi kupanga kwa VLDL. Izi zimabweretsa kuchotsedwa kwa LDL komanso kuchepa kwa kuchuluka kwake komanso zazing'onoting'ono.

Mutha kuwerengera ndemanga pakugwiritsa ntchito mankhwalawa kumapeto kwa nkhaniyo mu gawo lapadera.

Zizindikiro zogwiritsidwa ntchito

Tricor amalembedwa pochiza mitundu yokhayokha ndi yosakanikirana ya hypercholesterolemia ndi hypertriglyceridemia ngati kugwiritsidwa ntchito kwa mankhwala azakudya kapena njira zina zochiritsira sizimabweretsa zotsatira zoyenera. Chothandiza kwambiri ndikugwiritsa ntchito mankhwalawa pamaso paziwopsezo zina, monga dyslipidemia mukasuta fodya kapena matenda oopsa.

Tricor adafotokozedwanso zochizira yachiwiri mtundu hyperlipoproteinemia. Mu milandu pamene hyperlipoproteinemia amalimbikira motsutsana ndi maziko a mankhwala othandiza.

• kuwonjezera chilolezo
• onjezani kuchuluka kwa cholesterol "yabwino",
• chepetsa kuchuluka kwa mafuta m'thupi,
• chepetsa ndende ya fibrogen,
• muchepetse kuchuluka kwa uric acid ndi mapuloteni othandizira m'magazi.

Palibe phindu pakumwa mankhwala.

Njira yogwiritsira ntchito

Mapiritsi amatengedwa pakamwa ponse. Ayenera kumizidwa ndi madzi ambiri.

M`pofunika kumwa mankhwala nthawi iliyonse, ngakhale kudya mankhwala ndi ndende ya yogwira 145 mg. Mukamagwiritsa ntchito mankhwala omwe ali ndi Mlingo wokulirapo, ndiye kuti, 160 mg, mapiritsi amayenera kumwedwa nthawi yomweyo ndi chakudya.

Kwa akulu, piritsi limodzi limayikidwa kamodzi patsiku. Anthu omwe amatenga Lipantil 200M kapena Tricor 160 amatha kuyamba kugwiritsa ntchito Tricor 145 nthawi iliyonse osasintha mlingo. Popanda kusintha mlingo, wodwalayo amatha kusintha kuchokera ku kutenga lipantil 200M kupita ku Tricor 160.

Okalamba amapatsidwa mlingo womwewo monga mwachizolowezi.

Mwa kuperewera kwa impso kapena kwa hepatic, mlingo umakambirana ndi adokotala.

Tricor amatchulidwa kuti azigwiritsa ntchito nthawi yayitali, malinga ndi chakudya chovomerezeka. zomwe zidalembedwa chida ichi chisanaperekedwe. Kugwiritsa ntchito bwino kwake kungayesedwe ndi dokotala kuti aphunzire kuchuluka kwa zamadzimadzi mu seramu yamagazi. Ngati zotsatira zoyenera sizinachitike m'miyezi ingapo, ndiye kuti mankhwalawo amasinthidwa.

Mankhwala osokoneza bongo sanawonedwe, koma ngati pali zizindikiro zilizonse, chithandizo chamankhwala ndichofunikira.

Gwiritsani ntchito mapiritsi pokhapokha mutakambirana ndi dokotala. Simuyenera kupereka mankhwalawo nokha. Tricor ungagulidwe kokha ndi mankhwala.

Kutulutsa mawonekedwe, zikuchokera

Tricor amapezeka mu mawonekedwe a mapiritsi oblong, omwe amaphatikizidwa ndi chopukutira cha filimu ya mtundu wowala. Mapale omwewo alembedwa ndi mawu olembedwa. Chiwerengero cha 145 chikuwonetsedwa mbali imodzi, logo ya FOURNIER imayikidwa mbali yachiwiri.

Mapiritsi a 145 mg alipo. Phukusili limatha kukhala ndi zidutswa 10 mpaka 300. Palinso fomu yotulutsira limodzi ndi Mlingo wa 160 mg yogwira ntchito. Phukusi limodzi limatha kukhala ndi zidutswa 10 mpaka 100. Mu bokosi limodzi lokhazikika momwe mankhwala amapangidwira, pamakhala matuza atatu okhala ndi mapiritsi ndi malangizo.

Popanga mankhwala, chinthu chachikulu chomwe chimagwira ndi micen: fenofibrate.

Zowonjezera ndi:

• lactose monohydrate,
• sodium lauryl sulfate,
• sucrose
• hypopellose,
• yokonza sodium
• silika
• crospovidone
• magnesium wakuba,
• lauryl sulfate.

Chipolopolochi chimaphatikizapo Opadry OY-B-28920.

Kuchita ndi mankhwala ena

Mukasankha Traicor koyamba, muchepetseni kuchuluka kwa coagulants omwe amagwiritsidwa ntchito ndikuwonjezera pang'onopang'ono mpaka pakufunika. Izi ndizofunikira posankha mtundu woyenera.

Kugwiritsa ntchito Tricor ndi cyclosporine kuyenera kuyendetsedwa mwamphamvu. Kuwongolera kwenikweni kwa kuphatikiza kwa mankhwalawa sikunaphunzire, koma milandu ingapo yayikulu yachitika ndikuchepa kwa ntchito ya chiwindi. Pofuna kupewa izi, muyenera kuwunikira nthawi zonse ntchito ya chiwindi, komanso kusintha pang'ono pazomwe zikuwonetsa kuyesedwa koyipa, ndikofunikira kuletsa kulandira Tricor.

Mukamagwiritsa ntchito mankhwalawa ndi HMG-CoA reductase inhibitors ndi ma fiber ena, pamakhala chiwopsezo cha kuledzera kwa minofu ya fiber.

Mukamagwiritsa ntchito Tricor ndi michere ya cytochrome P450. kuwunika kwa ma microsomes kumawonetsa kuti fenofibroic acid ndi zotuluka zake sizoletsa cytochrome P450 isoenzymes.

Mukamagwiritsa ntchito mankhwalawa ndi glitazones, kuchepa kwaposachedwa kwamphamvu kwa ndende ya HDL m'magazi kumawonedwa. Chifukwa chake, mukamamwa mankhwalawa, muyenera kuwongolera kuchuluka kwa cholesterol ya HDL. Ngati imagwera pansipa, muyenera kusiya kumwa Tricor.

Zotsatira zoyipa

Tricorrh ali ndi zotsatira zoyipa, atazindikira zomwe zimayenera kusiya kugwiritsa ntchito mankhwalawa ndikuyang'ana kwa dokotala.

Zotsatira zoyipa:

• dyspeptic phenomena
• kuchuluka kwa michere ya chiwindi,
• kupweteka m'mimba
• kufinya ndi kufooka kwa minofu,
• nseru
• kusanza
• phatikizani myalgia,
• mutu
• chisangalalo
• kutsegula m'mimba
• kuchuluka kwa kuchuluka kwa magazi a leukocytes ndi hemoglobin,
• zotupa
• kuyabwa
• kusowa pogonana
• urticaria
• alopecia
• mitsempha yakuya.

Zotsatira zoyipa:

• myopathy
• kuchuluka kwa CPK,
• thupi siligwirizana
• chiwindi
• kapamba
• kuchuluka kwa seramu transaminase ndende,
• pneumopathy
• mawonekedwe amiyala yamiyala,
• zithunzi
• myositis
• kuchuluka kwa ndende ya urea ndi creatinine,
• khalokuz
• pulmonary embolism
• zithunzi.

Kuchiritsa katundu

Zomwe zimagwira ntchito ya Tricor ndi fenofibrate, yomwe ili m'gulu la mankhwala omwe amachepetsa lipid - mafupa.

Metabolite yogwira ya fenofibrate imalumikizana ndi ma receptors apadera. Imagwira:

• kuchepa kwamafuta
• chimbudzi cha triglycerides kuchokera m'madzi a m'magazi,
• kuchuluka kwa apolipoproteins omwe ali ndi lipid metabolism.

Zotsatira zake, kuchuluka kwa lipoproteins otsika kwambiri (LDL) komanso ochepa otsika lipoproteins (VLDL) m'mwazi amachepa. Miyezo yokwera ya LDL ndi VLDL imawonjezera ngozi yamafuta pamakoma amitsempha yamagazi (atherosulinosis). Nthawi yomweyo, zomwe zili ndi kuchuluka kwambiri kwa ma cell lipoproteins (HDL) zimachulukana, zomwe zimayendetsa mafuta osagwiritsidwa ntchito m'thupi kupita m'chiwindi, zomwe zimalepheretsa kuchitika kwa atherosclerosis.

Kuphatikiza apo, mukatenga fenofibrate, njira ya LDL catabolism imakonzedwa, zomwe zimatsogolera kuwonjezeka kwawo ndikuchepa kwa zomwe zili tinthu tating'onoting'ono tomwe timakhala koopsa kwambiri m'mitsempha yamagazi.

Kugwiritsa ntchito fenofibrate kumachepetsa cholesterol yokwanira 20-25%, triglycerides ndi 40-55% ndipo kumakulitsa "mafuta othandiza" HDL cholesterol ndi 10-30%.

Zomwe zikuwonetsa chithandizo cha mankhwalawa ndi izi: mtundu IIa, IIb, III, IV ndi V mtundu hyperlipidemia malinga ndi Fredrickson. Kuphatikiza apo, Tricor yochokera ku cholesterol amalembedwa kwa odwala omwe ali ndi matenda a mtima kapena omwe ali ndi chiopsezo chake. Amagwiritsidwa ntchito kuphatikiza mankhwala ndi ma statins odwala omwe ali ndi mtima wamatenda kapena mtundu wa 2 shuga.

Tricor amakhudza zomwe zili ma lipoprotein omwe samakhudzidwa ndi ma statins. Kumwa mankhwalawa kumatha kuchepetsa zovuta za matenda ashuga, kuphatikizapo kupitilira kwa matenda ashuga a retinopathy ndi nephropathy.

Zotsatira zoyipa zomwe mumamwa mukalandira mankhwalawa ndi:

• matenda am'mimba
• kuchuluka kwa ma seramu transaminases,
• kuwonongeka kwa minofu (kufooka kwa minofu, myalgia, myositis),
• thromboembolism
• mutu
• zimachitika pakhungu.

Kusamala ndikofunikira kuti muchepetse zotsatira zoyipa. M'chaka choyamba cha mankhwala, ntchito ya chiwindi transaminase iyenera kuyang'aniridwa miyezi itatu iliyonse. M'miyezi itatu yoyambirira ya mankhwalawa, tikulimbikitsidwa kudziwa kuchuluka kwa creatinine. Myalgia ndi matenda ena akaonekera, njira ya mankhwalawa imayimitsidwa.

Mankhwalawa amachitika kwa nthawi yayitali kuphatikiza ndi zakudya zapadera komanso kuyang'aniridwa ndi dokotala.

Mphamvu ya chithandizo imayesedwa ndi zomwe zili lipids (chonsele cholesterol, LDL, triglycerides) mu seramu yamagazi. Popeza palibe chithandizo pambuyo pa miyezi 3-6 ya mankhwalawa, ndikofunika kuyamba njira ina yothandizira.

Fenofibrate ali ndi zaka zambiri akugwiritsa ntchito, adapangidwa ndi French Fournier Laboratory zochizira cholesterol zaka 40 zapitazo.

Mtundu womasulidwa wa Tricor ndi mapiritsi okhala ndi 145 kapena 160 mg pazomwe zimagwira. Phukusili lili ndi magome 10 mpaka 300.

Mankhwala ofanana

Cholesterol treicor imapangidwa ku Fournier Laboratory ya SCA (France).

Kwa Tricor cholowa ndimankhwala okhala ndi zinthu zomwezi yogwira ntchito (fenofibrate). Mndandanda wamankhwala osokoneza bongo ndi wopapatiza.

Pali mankhwala okwera mtengo kwambiri kuchokera kwa omwe amapanga - Lipantil 200 M, omwe ali ndi zinthu zambiri zogwira - 200 mg motsutsana ndi 145 mg ku Tricor. Lipantil amapezeka m'mapiritsi otsekemera-obisika.

Mankhwala otsika mtengo ochokera ku Russia ndi Fenofibrat Canon. Wopanga mankhwalawa, kampani ya Canonfarm, amapereka makasitomala ambiri mapiritsi okhala ndi mapiritsi osiyanasiyana: 10, 20, 28, 30, 50, 60, 84, 90, 98, 100 ma PC.

Mapiritsi a Tricor amatha kusinthidwa m'malo ena awiri omwe amapezeka m'mabotolo. Awa ndi Grofibrate, omwe amapangidwa ndi Grodziskie Zaklady Farmaceutyczne Polfa (Poland), ndi Exlip ochokera kwa Nobel Ilac Sanayii Ve Ticaret A.S. (Turkey). Grofibrat ili ndi 100 mg ya fenofibrate, Exlip - 250 mg. Komabe, mankhwalawa pakalipano sapezeka kuti agulitsidwe.

M'mayiko ena, ambiri mwa mankhwala omwewo amagulitsidwa pansi pa dzina la brand, lomwe limasiyana ndi dzina la wopanga mankhwala (generic). Izi ndi monga: Antara, Fenocor-67, Fenogal, Fibractiv 105/35, etc.

Ku Russia, Trikor ya cholesterol ikugulitsidwa. Ngakhale mtengo wokwera mtengo, ukufunika.

Kuphatikiza pa majini omwe alembedwa, mutha kugulanso mankhwala omwe ali ndi vuto lofananalo, koma okhala ndi gawo lina lokhala ndi gawo lina la mankhwala. Pakati pawo: Atoris, Atorvastatin, Tevastor, Tribestan, etc.

Mutha kusintha Tricor ndi ma analogu pokhapokha mutagwirizana ndi dokotala.

Ndemanga za Tricorr ndi mayendedwe ake

Odwala ambiri amati Tricor ndi njira yabwino yochepetsera ma lipids a magazi. Komabe, ambiri amadziwa kuti nthawi yamankhwala, zovuta zake zidadziwika: zovuta zam'mimba, kunyansidwa, flatulence, ndi zina zambiri.

Malingaliro a madokotala okhudza mankhwalawa amasiyanasiyana. Ena amagwiritsa bwino Tricor kuchokera ku cholesterol ndipo amakhutira kwathunthu ndi zotsatira zomwe amapeza panthawi ya chithandizo. Ambiri a endocrinologists amaika Tricor mwachangu, chifukwa amawona kuti ndi njira yokhayo yotetezera odwala ku zovuta za shuga.

Akatswiri ena amakonda zolowa mmalo, chifukwa amakhulupirira kuti zovuta zomwe zingachitike zimathetsa zotsatirapo zabwino pakuchepetsa lipids zovulaza.

Kutulutsa mawonekedwe ndi kapangidwe kake

Tricor amagulitsidwa monga mapiritsi okhala ndi filimu mu phukusi la mapiritsi 30. Piritsi lirilonse limakhala ndi fenofibrate ya micronized 145 mg, ndi zinthu zotsatirazi:

• lactose monohydrate,
• sodium lauryl sulfate,
• sucrose
• hypopellose,
• silicon dioxide
• crospovidone
• script sodium.

Zochizira

Fenofibrate ndichokera ku fibric acid. Imatha kusintha magawo azigawo zosiyanasiyana za lipids m'magazi. Mankhwala ali ndi mawonekedwe awa:

1. Kuchulukitsa chilolezo
2. Kuchepetsa kuchuluka kwa atherogenic lipoproteins (LDL ndi VLDL) mwa odwala omwe ali pachiwopsezo cha matenda a mtima,
3. Kweza mulingo wa cholesterol "wabwino" (HDL),
4. Amachepetsa kwambiri zomwe zimapangitsa kuti ma cholesterol agwiritsidwe ntchito,
5. Lowers fibrinogen ndende,
6. Imachepetsa mulingo wa uric acid m'magazi komanso mapuloteni C osagwira.

Mulingo wambiri wa fenofibrate m'magazi a anthu umawonekera patangopita maola ochepa mutangogwiritsa ntchito kamodzi. Pazinthu zomwe zimagwiritsidwa ntchito kwa nthawi yayitali, palibe zotsatira zowonjezera.

Kugwiritsa ntchito mankhwala Tricor pa mimba

Zidziwitso zazing'ono zanenedwapo zakugwiritsa ntchito fenofibrate panthawi yapakati. Poyeserera nyama, mphamvu ya teratogenic ya fenofibrate idawululidwa.

Embryotoxicity anakhalapo mu mawonekedwe a preclinical mayesero pankhani ya Mlingo poizoni thupi la mayi wapakati. Pakadali pano, palibe chiwopsezo kwa anthu chomwe chadziwika. Komabe, mankhwalawa pa nthawi ya pakati amatha kugwiritsidwa ntchito pokhapokha pakuwunika mosamala kuchuluka kwa mapindu ndi zoopsa.

Popeza palibe zambiri zolondola zokhudzana ndi chitetezo cha mankhwalawa Tricor pa nthawi yoyamwitsa, ndiye kuti panthawiyi sichinalembedwe.

Otsutsa otsatirawa kumwa mankhwala Tricor ndi:

• Kutengeka kwakukulu mu fenofibrate kapena zigawo zina za mankhwala,
• Kulephera kwakukulu kwa aimpso, monga matenda amchiwindi,
• Osakwana zaka 18
• Mbiri ya photosensitization kapena Phototoxicity pa mankhwala a ketoprofen kapena ketoprofen,
• Matenda osiyanasiyana a ndulu,
• Kuyamwitsa
• Endo native galactosemia, osakwanira lactase, malabsorption wa galactose ndi glucose (mankhwalawa ali ndi lactose),
• Endo native fructosemia, sucrose-isomaltase akusowa (mankhwalawa ali ndi sucrose) - Tricor 145,
• Momwe thupi limasokonekera ndi batala la nandolo, mtedza, soya lecithin, kapena mbiri yofananira yazakudya (popeza pali chiwopsezo cha hypersensitivity).

Ndikofunikira kugwiritsa ntchito malonda mosamala, ngati alipo:

1. Kulephera kwamkati ndi / kapena chiwindi,
2. Mowa
3. Hypothyroidism,
4. Wodwala ali wokalamba,
5. Wodwalayo ali ndi mbiri yakale chifukwa cha matenda obadwa nawo a minofu.

Mlingo wa mankhwala ndi njira yogwiritsira ntchito

Mankhwalawa amayenera kutengedwa pakamwa, kumeza lonse ndikumwa madzi ambiri. Piritsi imagwiritsidwa ntchito nthawi iliyonse ya tsiku, sizimadalira chakudya chambiri (cha Tricor 145), komanso nthawi yomweyo ndi chakudya (cha Tricor 160).

Akuluakulu amatenga piritsi limodzi kamodzi patsiku. Odwala omwe amatenga kapisozi imodzi ya Lipantil 200 M kapena piritsi 1 la Tricor 160 patsiku amatha kuyamba kutenga piritsi limodzi la Tricor 145 popanda kusintha kwa mlingo wina.

Odwala omwe amatenga kapisozi imodzi ya Lipantil 200 M patsiku ali ndi mwayi wosinthira piritsi limodzi la Tricor 160 popanda kusintha kwa mlingo wina.

Odwala okalamba ayenera kugwiritsa ntchito mlingo woyenera wa akulu: piritsi limodzi la Tricor kamodzi patsiku.

Odwala omwe ali ndi vuto la impso ayenera kuchepetsa kuchuluka kwa kufunsa dokotala.

Chonde dziwani: kugwiritsa ntchito mankhwala Tricor mwa odwala omwe ali ndi matenda a chiwindi sanaphunzire. Ndemanga sizimapereka chithunzi chomveka.

Mankhwalawa amayenera kumwa kwa nthawi yayitali, ndikuyang'ana zofunikira za zakudya zomwe munthu adatsata asanayambe kugwiritsa ntchito mankhwalawa. Kugwiritsa ntchito bwino kwa mankhwalawa kuyenera kuwunikiridwa ndi dokotala.

Chithandizo chimayesedwa ndi milingo ya serum lipid. Tikulankhula za LDL cholesterol, cholesterol yathunthu ndi triglycerides. Ngati chithandizo chamankhwala sichinachitike pakatha miyezi yochepa, ndiye kuti njira yina yochiritsira ndiyofunika kukambirana.

Momwe mankhwalawa amakhudzirana ndi mankhwala ena

1. Ndi anticoagulants mkamwa: fenofibrate imathandizira kugwira ntchito kwa anticoagulants pamlomo ndikuwonjezera ngozi ya kutuluka magazi. Izi ndichifukwa chosamutsidwa kwa ma anticoagulant kuchokera kumalo omanga mapuloteni a plasma.

Pa magawo oyamba a mankhwala a fenofibrate, ndikofunikira kuti muchepetse mlingo wa anticoagulants ndi wachitatu, pang'onopang'ono kusankha mlingo. Mlingo uyenera kusankhidwa motsogozedwa ndi mulingo wa INR.

1. Ndi cyclosporine: mafotokozedwe angapo woopsa milandu yafupika chiwindi ntchito mankhwala ndi cyclosporine ndi fenofibrate. Ndikofunikira kuyang'anira ntchito ya chiwindi nthawi zonse mu odwala ndikuchotsa fenofibrate ngati pali kusintha kwakukulu pamagawo a labotale.
2. Ndi HMG-CoA reductase inhibitors ndi ma fiber ena: mukamatenga fenofibrate ndi HMG-CoA reductase inhibitors kapena ma fiber ena, chiopsezo cha kuledzera pa minofu ya minofu imakulanso.
3. Ndi ma enzymes a cytochrome P450: kafukufuku wama microsomes a chiwindi cha anthu amawonetsa kuti fenofibroic acid ndi fenofibrate sakhala ngati zoletsa za cytochrome P450 isoenzymes:

• CYP2D6,
• CYP3A4,
• CYP2E1 kapena CYP1A2.

Pa mankhwalawa othandizira, mankhwala awa ndi olepheretsa CYP2C19 ndi CYP2A6 isoenzymes, komanso ma CYP2C9 inhibitors ocheperako.

Malangizo apadera ochepa mukamamwa mankhwalawa

Musanayambe kugwiritsa ntchito mankhwalawa, muyenera kuchitira mankhwala omwe cholinga chake ndi kuthetsa zomwe zimayambitsa matenda ena owopsa a hypercholesterolemia, omwe tikukambirana:

• shuga wachiwiri wosalamulirika,
• hypothyroidism
• nephrotic syndrome
• dysproteinemia,
• matenda a chiwindi
• Zotsatira zamankhwala
• uchidakwa.

Mphamvu ya chithandizo imawunikidwa potengera zomwe zili lipids:

• cholesterol yathunthu
• LDL
• seramu triglycerides.

Ngati chithandizo chamankhwala sichinawonekere kwa miyezi yopitilira atatu, ndiye kuti njira ina yothandizira kapena yothandizirana ndiyenera kuyamba.

Odwala omwe ali ndi hyperlipidemia omwe amatenga njira zakulera za mahomoni kapena estrogens ayenera kudziwa mtundu wa hyperlipidemia, ikhoza kukhala yoyamba kapena yachiwiri. Muzochitika izi, kuwonjezereka kwa lipids kumatha kuyambitsidwa ndi kudya kwa estrogen, komwe kumatsimikiziridwa ndi kuwunika kwa odwala.

Mukamagwiritsa ntchito Tricor kapena mankhwala ena omwe amachepetsa kuchuluka kwa lipids, odwala ena amatha kuwona kuwonjezeka kwa hepatic transaminases.

Mwambiri, kuchuluka kumakhala kocheperako komanso kwakanthawi, kumadutsa popanda chizindikiro chowoneka. Kwa miyezi 12 yoyambirira ya mankhwalawa, ndikofunikira kuyang'anitsitsa kuchuluka kwa transaminases (AST, ALT), miyezi itatu iliyonse.

Odwala omwe, panthawi ya chithandizo, amakhala ndi kuchuluka kwa transaminases, amafunikira chisamaliro chapadera ngati kuchuluka kwa ALT ndi AST ndi 3 kapena kuposa nthawi yayitali kuposa poyambira. Zikatero, mankhwalawa amayenera kuimitsidwa msanga.

Pancreatitis

Pali mafotokozedwe amilandu ya chitukuko cha kapamba panthawi yogwiritsa ntchito Traicor. Zoyambitsa za kapamba:

• Kuperewera kwa mankhwalawa kwa anthu omwe ali ndi vuto lalikulu la hypertriglyceridemia,
• Kuwonetsedwa mwachindunji ndi mankhwalawo,
• Kuwonetsera kwachiwiri komwe kumalumikizidwa ndi miyala kapena mapangidwe a matope mu ndulu, yomwe imayendetsedwa ndi kutsekeka kwa wamba bile duct.

Pogwiritsa ntchito Tricor ndi mankhwala ena omwe amachepetsa kuchuluka kwa lipids, milandu ya poizoni wama minofu imanenedwapo. Kuphatikiza apo, milandu yachilendo ya rhabdomyolysis amalembedwa.

Mavuto oterewa amakula pafupipafupi ngati pali zovuta zolephera za impso kapena mbiri ya hypoalbuminemia.

Mavuto azovuta zama minofu amatha kukayikiridwa ngati wodandaula adandaula:

• Minofu kukokana ndi kukokana,
• Zofooka zambiri
• Diffuse myalgia,
• Myositis
• Kukula kodziwika kwa ntchito ya creatine phosphokinase (kasanu kapena kuposerapo poyerekeza ndi malire apamwamba).

Ndikofunikira kudziwa kuti pazochitika zonsezi, chithandizo ndi Tricor ziyenera kusiyidwa.

Odwala omwe amatchulidwa kuti myopathy, mwa anthu achikulire zaka 70, komanso odwala omwe ali ndi mbiri yolemetsa, rhabdomyolysis imatha kuoneka. Kuphatikiza apo, zinthu zimasokonekera:

1. Matenda a minofu
2. Matenda a impso,
3. Hypothyroidism,
4. Mowa.

Mankhwalawa amalangizidwa kwa odwala pokhapokha ngati chithandizo chomwe akuyembekezeredwa chithandizo chikuchuluka kwambiri kuopsa kwa rhabdomyolysis.

Mukamagwiritsa ntchito Traicor limodzi ndi HMG-CoA reductase inhibitors kapena ma fiber ena, chiopsezo cha zovuta zowopsa pakhungu la minofu chimakulanso. Izi zimachitika makamaka pamene wodwalayo anali ndi matenda a minofu asanayambe chithandizo.

Kuphatikiza pamodzi ndi Triicor ndi statin kungakhale kokha ngati wodwalayo ali ndi dyslipidemia wosakanikirana komanso chiopsezo cha mtima. Sipangakhale mbiri yokhudza matenda a minofu. Kuzindikirika kwambiri kwa zizindikiro za poizoni m'thupi.

Ntchito yamalonda

Ngati kuwonjezeka kwa kuchuluka kwa creatinine kwa 50% kapena kupitilira kwalembedwa, ndiye kuti mankhwalawa ayenera kuyimitsidwa. M'miyezi itatu yoyambirira ya chithandizo ndi Triicor, ndende ya creatinine iyenera kutsimikizika.

Ndemanga za mankhwalawa zilibe chidziwitso pakusintha kwathanzi poyendetsa galimoto ndikuwongolera makina.

Contraindication

Mankhwala contraindised mu zotsatirazi mavuto:

• matenda a chiwindi
• matenda a impso
• matenda amatsenga
• kusalolera shuga,
• matenda a gallbladder
• kukhudzana ndi zithunzi
• Matupi a soya lecithin, mtedza ndi zakudya zofanana.

Ana ndi okalamba salimbikitsidwa kumwa mankhwalawa. Tricor sayenera kugwiritsidwa ntchito powona kusakhazikika kwa anthu pazigawo zam'mapiritsi.

Kupatula pokhapokha ngati mankhwalawa agwiritsidwa ntchito povomerezeka, itha kugwiritsidwa ntchito mosamala kwambiri ngati:

• kumwa mowa
• kulephera kwa aimpso
• kulephera kwa chiwindi
• hypothyroidism
• cholowa cham'mimba,
• kugwiritsa ntchito pamodzi.

Tiyeneranso kukumbukira kuti musanasankhe Traicor, muyenera kuthana ndi mavuto ena azaumoyo:

• mtundu 2 shuga
• hypothyroidism
• nephrotic syndrome,
• dysproteinemia,
• matenda a chiwindi
• uchidakwa
• Zotsatira za mankhwala.

Pa nthawi yoyembekezera

Tricor ndiwotsimikizika motsutsana mwa amayi ndi amayi apakati pa mkaka wa m`mawere.

Komabe, mayesero azachipatala otsimikizira zovuta pa mwana wosabadwayo sanachitidwe. Komabe, embryotoxicity adawonetsedwa poika Mlingo poizoni m'thupi la mayi wapakati. Ngakhale mankhwalawa sanapangidwire amayi apakati, nthawi zina amaperekedwa kwa azimayi panthawiyi poyesa kuchuluka kwa phindu ndi ngozi.

Komanso, mavuto a Tricor pa ana oyamwitsa sanawonekere, chifukwa chake madokotala amayesetsa kuti asamwe mankhwala panthawiyi.

Migwirizano ndi magwiritsidwe akusungidwa

Tricor iyenera kusungidwa mumapangidwe a wopanga. Kuphatikiza apo, kutentha kosaloledwa kotentha ndi madigiri 25.

Alumali moyo wa mankhwala zimadalira ndende ya yogwira mankhwala. Mukamagula mapiritsi mu mlingo wa 145 mg, moyo wawo wa alumali amatha kufikira zaka zitatu. Mukamagwiritsa ntchito mapiritsi Mlingo wa 160 mg, moyo wa alumali umachepetsedwa ndi chaka chimodzi ndipo ndi zaka ziwiri.

Mtengo wa mankhwalawa umatengera osati phukusi la phukusi (kuchuluka kwa mapiritsi omwe ali momwemo) momwe amapangidwira, komanso chidwi ndi zomwe zimagwira.

Mtengo wapakati ku Ukraine

Mutha kugula Tricor ku Ukraine pamtengo wa 340 mpaka 400 hhucnias phukusi lililonse la mankhwalawa muyezo wa 145 mg (mapiritsi 20).

Mankhwala otsatirawa ndi amtundu wa Traicor:

Kugwiritsa ntchito analogues kumaloledwa pokhapokha mukaonana ndi dokotala ndikusankha kuchuluka kofunikira.

Kuphatikiza apo, mankhwalawa ali ndi ma syonyms. Uku ndi Lipantil 200M. Exlip. Fenofibrat Canon.

Ndemanga zambiri pazogwiritsa ntchito Tricor ndizosakanikirana. Madokotala ena amapereka mankhwala Onani zabwino zakuchepa ndi kusintha kwa mawonekedwe a lipid.

Madokotala ena komanso odwala amakakamizidwa kusiya kugwiritsa ntchito mankhwalawa, chifukwa zotsatira zake zoyipa zimapambana pazotsatira zabwino zogwiritsidwa ntchito.

Mulimonsemo, mutha kuthira Tricor chithandizo pokhapokha mutakumana ndi dokotala ndikuwona momwe impso ndi chiwindi zilili. Pokhapokha ngati pali zovuta zilizonse zomwe zingayambitse kuwonongeka kwa thanzi la wodwalayo, ndikotheka kumwa mapiritsiwo.

Ndemanga zokhudzana ndi mankhwalawa zilibe chidziwitso pa kusintha kwa moyo wa munthu poyendetsa.

• Tricor amalembera mankhwalawa a hyperlipoproteinemia, omwe sangathe kukonza ndi zakudya.
• Gwiritsani ntchito mankhwalawa pokhapokha ngati mwalangizidwa ndi dokotala.
• Mankhwala onse amagwiritsidwa ntchito mkati, mosasamala nthawi yakudya (kupatula kumwa mapiritsi a 160 mg).
• Tricor imaphatikizidwa panthawi yapakati ndi kukomoka, chiwindi ndi kukanika kwa impso, hypersensitivity ku zigawo za mankhwala, komanso osavomerezeka kwa ana.
• Mankhwala ali ndi zotsatira zoyipa zingapo.
• Chenjezo limalangizidwa kugwiritsa ntchito Tricor ndi mankhwala ena.

Kodi nkhaniyo yakuthandizani? Mwina azithandizanso anzanu! Chonde, dinani kumodzi mwa mabataniwo:

Analogs Tricor

Machesi molingana ndi mawonekedwe

Mtengo wake umachokera ku ma ruble 418. Analogue ndiotsika mtengo ndi ma 380 rubles

Machesi molingana ndi mawonekedwe

Mtengo wake umachokera ku ma ruble 433. Analogue ndiotsika mtengo ndi ma ruble 365

Machesi molingana ndi mawonekedwe

Mtengo wake umachokera ku ma ruble 604. Analogue ndiyotsika mtengo ndi ma ruble 194

Madokotala amawunikiranso za traicor

Ndi bwino ngati muyenera kusintha mulingo wa triglycerides.

Kuchita kwakeko sikwodziwikiratu ndipo kuchuluka kwake kwakachitika nthawi ndi nthawi kumabweretsa mafunso ambiri.

M'malo mwake, fenofibrate imakhala yabwino kwambiri muzochita zamtima komanso za endocrinological kwa hypertriglyceridemia. Monga mukudziwira, ma endocrinologists, makamaka masiku ano, amangokhala otanganidwa ndi ntchito ya triglycerides, ndipo pozindikira hypertriglyceridemia muzochita zamtima, ndimayipangira kuti ndi njira yosankhira.

"Tricor" ndi wothandizira wa hypolipidemic, koma kwakukulu kumachepetsa triglycerides. Ndikupangira mitundu IIa, IIb, III ndi IV hyperlipoproteinemia. Mlingo ndi nthawi ya mankhwala - payekhapayekha. Palibe mavuto omwe adawonedwa.

Zilibe gawo lililonse pochepetsa cholesterol. Contraindicated mu kwambiri chiwindi matenda.

Umboni Wodwala

Ndili ndi malingaliro oyipa okhudza zoyendera. Anatenga pafupifupi chaka chimodzi m'malo mwa torvacard. Chifukwa chachikulu chomwe chimasinthidwa ndikutsitsa kwa HDL nthawi zonse ndikutenga torvacard. Pambuyo pa miyezi 4-5, magawo a paroxysmal a bloating and nausea anayamba kuonekera - nthawi ziwiri pamwezi, ndipo miyezi 8-9 pambuyo poti kuukira kwotsatira kugwiriridwa (zaka 3 zapitazo) ka colic. Mu chikhodzodzo cha ndulu yomwe imachotsedwa pali viscous bile ndi miyala ina yotayirira. Panalibe mavuto am'mimba komanso chikhodzodzo musanatenge treicor. Pambuyo pa opareshoni, kuukira kunatha. Izi zoyipa zikufotokozedwa mu malangizo a mankhwala.

Ndimakhala mumzinda wa Stavropol ndekha, wazaka - zaka 53. Ndimamwa "Tricor" kuyambira chaka cha 2013. Ndinalemba zolemba zam'maso Irina Olegovna Gadzalova. Matenda anga: matenda ashuga retinopathy. Diso lakumanzere - ma opaleshoni atatu pa retina, mandala m'malo mwa IOL, laser coagulation mobwerezabwereza. Diso lakumanja - ma opaleshoni awiri a retina (imodzi yokhudzana ndi kukokoloka), IOL, laser. Chifukwa cha "Tricor", kuchiritsa masinthidwe am'mbuyo ndikosavuta komanso kwabwinoko. Kuphatikiza apo, "Tricor" amatsitsa cholesterol yamagazi kukhala yabwinobwino. Ndimamwa pafupipafupi (miyezi 10 - ndiye miyezi 2 yopuma). Sindinazindikire mavuto aliwonse.

Pharmacokinetics

Mutatha kutenga fenofibrate mkati C_max zimatheka mkati mwa maola 5. Mukamamwa 200 mg / tsiku, pafupifupi plasma ndende ndi 15 μg / ml. Mtengo C_ss anakhalabe nthawi yonseyi. Kulumikizana ndi mapuloteni a plasma (albin) ndikokwera. Mu minofu, fenofibrate imasandulika yogwira metabolite - fenofibroic acid. Wopangidwira m'chiwindi.

T_1/2 ndi ma maola 20. Amakumba impso kudzera m'matumbo. Sichikundikira, sichimakumba nthawi ya hemodialysis.