Ofloxin 200 (Ofloxin® 200)

Kufotokozera kogwirizana ndi 21.04.2016

• Dzina lachi Latin: Ofloxacin
• Code ya ATX: J01MA01
• Chithandizo: Ofloxacin (Ofloxacin)
• Wopanga: Pharmstandard-Leksredstva, Synthesis Kurgan Joint-Stock Company of Medicines and Products OJSC, Valenta Pharmaceuticals, Skopinsky Pharmaceutical Plant, MAKIZ-PHARMA, Obolenskoye - bizinesi yamankhwala, Rafarma ZAO, Ozon LLC, Krasfarma, Biosynthesis OJSC (Russia)

• Mu 1 piritsi - 200 ndi 400 mg ofloxacin. Wowuma, MCC, talc, magnesium stearate, polyvinylpyrrolidoneMa airer monga zida zothandizira.
• Mu 100 ml yankho - 200 mg yogwira ntchito. Sodium chloride ndi madzi, monga zigawo zothandiza.
• Mu 1 g mafuta odzola - 0,3 g yogwira ntchito. Nipagin, mafuta odzola, nipazole, ngati othandizira.

Mankhwala

Kodi Ofloxacin ndi antiotic kapena ayi? Izi siziri mankhwala, ndi antibacterial wothandizila kuchokera pagululi quinolones ofundasizomwezo. Osiyana ndi maantibayotiki momwe amapangira komanso komwe adachokera. Fluoroquinolones alibe analogue m'chilengedwe, ndipo maantibayotiki ndi zinthu zachilengedwe.

Mphamvu ya bactericidal imalumikizidwa ndi chopinga cha DNA gyrase, chomwe chimakhudza kuphwanya kwa kaphatikizidwe ka DNA ndi magawikidwe a maselo, kusintha kwa khoma la cell, cytoplasm ndi cell cell. Kuphatikizidwa kwa atomu ya fluorine mu molekyulu ya quinoline kunasintha chiwonetsero cha antibacterial kanthu - chawonjezeka kwambiri ndikuphatikizanso tizilombo tosamva maantibayotiki omwe amapanga beta-lactamases.

Ma microorganism a grram-gramu komanso gram alibe chidwi ndi mankhwalawo chlamydia, ureaplasmas, mycoplasmas, gardnerella. Imalepheretsa kukula kwa mycobacteria chifuwa chachikulu. Sizikhudza Treponema pallidum. Kukana kwa Microflora kumayamba pang'onopang'ono. Zotsatira zotchulidwa pambuyo pothana ndi mabakiteriya zimadziwika.

Pharmacokinetics

Mafuta pambuyo kumeza ndi bwino. Bioavailability 96%. Gawo losafunikira la mankhwala limamangiriza mapuloteni. Kuzindikira kwakukulu kumatsimikiziridwa pambuyo pa 1 h. Imagawidwa bwino mu minofu, ziwalo ndi zamadzimadzi, kulowa mkati mwa maselo. Kuzungulira kwazinthu kwakukulu kumawonedwa ndi malovu, sputum, mapapu, myocardium, mucosa wamatumbo, mafupa, minofu ya prostate, ziwalo zoberekera za akazi, khungu ndi fiber.

Imalowa bwino kudzera mu zotchinga zonse komanso kulowa mu madzi amchere. Pafupifupi 5% ya mankhwalawa ndi biotransformed mu chiwindi. Hafu ya moyo ndi maola 6-7. Ndi makonzedwe obwerezabwereza, kukondwerera sikufotokozedwa. Imafufutidwa ndi impso (80-90% ya mlingo) ndi gawo laling'ono ndi bile. Ndi kulephera kwa aimpso, T1 / 2 imawonjezeka. Ndi kulephera kwa chiwindi, kuchiritsa kumathanso kuchepa.

Zizindikiro zogwiritsidwa ntchito

• bronchitis, chibayo,
• Matenda a ENTpharyngitis, sinusitis, otitis media, laryngitis),
• matenda a impso ndi kwamikodzo (pyelonephritis, matenda amitsempha, cystitis),
• matenda a pakhungu, minofu yofewa, mafupa,
• endometritis, salpingitis, parametritis, oophoritis, khomo lachiberekero, colpitis, prostatitis, khungu, orchitis,
• chinzonono, chlamydia,
• zilonda zam'mimba blepharitis, conjunctivitis, keratitis, barele, zotupa za maso, kuteteza matenda pambuyo povulala ndi ntchito (yamafuta).

Contraindication

• wazaka 18
• Hypersensitivity
• mimba,
• yoyamwitsa,
• khunyu kapena kuwonjezereka kukonzekera pambuyo povulala mwanjira ya ubongo, ngozi ya m'matumbo ndi matenda ena amkati mwa dongosolo lamanjenje,
• kale anati tendon kuwonongeka pambuyo makonzedwe chimfine,
• zotumphukira neuropathy,
• tsankho lactose,
• zaka mpaka 1 chaka (mafuta).

Mochenjera, mankhwalawa amalembedwera matenda aubongo, myasthenia graviskuphwanya kwambiri chiwindi ndi impso, hepatic porphyria, kulephera kwa mtima, matenda ashuga, myocardial infarationparoxysmal yamitsempha yamagazi tachycardia, bradycardiamuukalamba.

Zotsatira zoyipa

Zotsatira zoyipa:

Zomwe zimachitika kawirikawiri komanso kawirikawiri kwambiri:

• kuchuluka kwa ntchito transaminase, cholestatic jaundice,
• chiwindi, hemorrhagic colitis, pseudomembranous colitis,
• mutu, chizungulire,
• kuda nkhawa, kusakhazikika,
• kusowa tulomaloto akulu
• nkhawa, phobias,
• kukhumudwa,
• kunjenjemerakukokana
• paresthesia wa miyendozotumphukira neuropathy,
• conjunctivitis,
• tinnitus kumva kuwonongeka,
• kuphwanya kwamtundu wamtundu, kuwona kawiri
• mavuto amakomedwe
• tendonitis, myalgia, arthralgiakupweteka miyendo
• kupindika kwa tendon
• palpitations yamitsempha yama khungu, matenda oopsa,
• chifuwa chowuma, kupuma movutikira, bronchospasm,
• petechiae,
• leukopenia, kuchepa magazi, thrombocytopenia,
• kuwonongeka kwaimpso, dysuria, kusungika kwamikodzo,
• zotupa pakhungu, urticaria,
• dysbiosis yamatumbo.

Bongo

Zimadziwulula yokha chizungulire, kubweza, kugona, chisokonezo, chisokonezo, spasms, kusanza. Chithandizo chimakhala ndi chapamimba cham'mimba, kukakamiza diuresis ndi chizindikiro. Ndi yogwira mtima matenda Diazepam.

Kuchita

Mukapangana sucralfataMaantacid okhala ndi zokonzekera zomwe zimakhala ndi aluminiyamu, zinc, magnesium kapena chitsulo, kuchepetsedwa kwa mayamwa ofloxacin. Pali kuwonjezeka kwa mphamvu ya mankhwala osagwirizana mukamamwa mankhwala. Kuyendetsa dongosolo la coagulation kumafunikira.

Chiwopsezo cha zotsatira za neurotoxic ndi ntchito zopweteka zimawonjezeka ndi makonzedwe amodzi a NSAIDs, zotumphukira. nitroimidazole ndi methylxanthines.

Mukamagwiritsa ntchito Theofylline chilolezo chake chimachepa ndipo kuwonongedwa kwa theka la moyo kumakulanso.

Kugwiritsira ntchito nthawi yomweyo kwa othandizira a hypoglycemic kungayambitse mikhalidwe ya hypo- kapena hyperglycemic.

Mukamagwiritsa ntchito Cyclosporine pali kuwonjezeka kwa kuchuluka kwake m'magazi ndi theka la moyo.

Mwinanso kuchepa kwambiri kwa kuthamanga kwa magazi mukamagwiritsa ntchito barbiturates ndi antihypertensive mankhwala.

Mukamagwiritsa ntchito glucocorticosteroids pamakhala chiwopsezo cha kupasuka kwa tendon.

Kutalika kwa nthawi ya QT ndikugwiritsa ntchito antipsychotic, antiarrhythmic mankhwala, ma tridclic antidepressants, macrolides, imidazole. astemizole, terfenadine, ebastina.

Kugwiritsa ntchito kaboni wa anhydrase inhibitors, sodium bicarbonate ndi ma citrate, omwe amachititsa kuti mkodzo uthandizidwe, umawonjezera chiopsezo cha crystalluria ndi nephrotoxicity.

Momwe mungagwiritsire ntchito: Mlingo ndi njira ya chithandizo

Mkati, mu / mkati. Mlingo wa Ofloxin 200 amasankhidwa payekha kutengera ndi komwe ali, kuwopsa kwa nthendayo, chidwi cha tizilombo, komanso momwe wodwalayo amagwirira ntchito ndi chiwindi ndi impso.

Mu / kumayambiriro kumayambira ndi limodzi mlingo wa 200 mg, womwe umayendetsedwa motsika, pang'onopang'ono kwa mphindi 30-60. Matenda a wodwalayo akayamba kuyenda bwino, amapatsidwa mankhwala omwe amakamwa pakumwa tsiku lomwelo.

Mu / mu: matenda a kwamkodzo - 100 mg 1-2 kawiri pa tsiku, matenda a impso ndi ziwalo - kuyambira 100 mg kawiri pa tsiku mpaka 200 mg kawiri pa tsiku, matenda amtundu wa kupuma, komanso ziwalo za ENT, matenda a pakhungu ndi minofu yofewa, matenda am'mafupa ndi mafupa, matenda am'matumbo, bacterial enteritis, matenda a septic - 200 mg kawiri pa tsiku. Ngati ndi kotheka, onjezani mlingo mpaka 400 mg 2 kawiri pa tsiku.

Kwa kupewa matenda odwala ndi kutchulidwa kuchepa chitetezo - 400-600 mg / tsiku.

Ngati ndi kotheka, iv drip - 200 mg mu 5% dextrose solution. Kutalika kwa kulowetsedwa ndi mphindi 30. Gwiritsani ntchito mayankho omwe mwakonzekera kumene.

Mkati: achikulire - 200-800 mg / tsiku, njira ya mankhwala - masiku 7-10, pafupipafupi kugwiritsa ntchito - 2 kawiri pa tsiku. Mlingo wa mpaka 400 mg / tsiku ukhoza kutumikiridwa mu 1 mlingo, makamaka m'mawa. Ndi chinzonono - 400 mg kamodzi.

Odwala omwe ali ndi vuto la impso (ndi CC 50-20 ml / min), muyezo umodzi uyenera kukhala 50% ya avareji ya pafupipafupi komanso kawiri pa tsiku. Ndi CC ochepera 20 ml / mphindi, mlingo umodzi ndi 200 mg, ndiye 100 mg / tsiku tsiku lililonse.

Ndi hemodialysis ndi peritoneal dialysis, 100 mg maola 24 aliwonse. Mlingo wambiri watsiku ndi tsiku wolephera chiwindi ndi 400 mg / tsiku.

Mapiritsi amatengedwa kwathunthu, kutsukidwa ndi madzi, musanadye kapena pakudya. Kutalika kwa mankhwalawa kumatsimikizika ndi chidwi cha pathogen ndi chithunzi cha chipatala, chithandizo chiyenera kupitilizidwa kwa masiku osachepera atatu kuchokera kutha kwa zizindikiro za matenda ndikukhazikika kwamtundu wa thupi. Mankhwalawa salmonella, njira ya mankhwala ndi masiku 7-8, ndi zovuta zovuta kwamkodzo kwamkodzo, maphunzirowa ndi masiku 3-5.

Zotsatira za pharmacological

Wothandizila kwambiri ma antimicrobial wothandizila kuchokera pagulu la fluoroquinolones amathandizira pa michere ya michere ya DNA gyrase, yomwe imapereka supercoiling, ndi zina zambiri. kukhazikika kwa mabakiteriya a DNA (kuphatikizika kwa maunyolo a DNA kumabweretsa kufa kwawo). Imakhala ndi bactericidal zotsatira.

Yogwira motsutsana ndi tizilombo tating'onoting'ono tokhala ndi beta-lactamases komanso mycobacteria yomwe ikukula mofulumira. Zovuta: Staphylococcus aureus, Staphylococcus epermidis, Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Citrobacter, Klebsiella spp. (kuphatikiza ndi Klebsiella chibayo), Enterobacter spp., Hafnia, Proteus spp. (kuphatikiza Proteus mirabilis, Proteus vulgaris - indole zabwino komanso indole hasi), Salmonella spp., Shigella spp. (Kuphatikizapo Shigella sonnei), Yersinia enterocolitica, Campylobacter jejuni, Aeromonas hydrophila, Plesiomonas aeruginosa, Vibrio cholerae, Vibrio parahaemolyticus, Haemophilus influenzae, mauka spp., Legionella spp., Serratia spp., Providencia spp., Haemophilus ducreyi, Bordetella parapertussis, Bordetella pertussis, Moraxella catarrhalis, Propionibacterium ziphuphu, Brucella spp.

Kuzindikira kosiyanasiyana kwa mankhwalawa kumakhala ndi: Enterococcus faecalis, Streptococcus pyogenes, chibayo ndi ma viridan, Serratia marcescens, Pseudomonas aeruginosa, Acinetobacter, Mycoplasma hominis, Mycoplasma pneumoniae, Mycobacteriumium tubulululum tubumercumosisumerculosis. monocytogene, Gardnerella vaginalis.

Mwambiri, osaganizira: Nocardia asteroides, bacteria wa anaerobic (mwachitsanzo. Bacteroides spp., Peptococcus spp., Peptostreptococcus spp., Eubacter spp, Fusobacterium spp., ClostridiumGHile). Zosagwira Treponema pallidum.

Malangizo apadera

Si mankhwala osankhidwa a chibayo chifukwa cha chibayo. Osati zochizira pachimake tonsillitis.

Sitikulimbikitsidwa kuti muzigwiritsa ntchito kwa miyezi yopitilira 2, kuwonetseredwa ndi kuwala kwa dzuwa, kuwotchera magetsi ndi UV mawondo (nyale-quartz, solarium).

Pankhani ya mavuto kuchokera chapakati mantha dongosolo, thupi lawo siligwirizana, pseudomembranous colitis, kusiya mankhwala ndikofunikira. Ndi pseudomembranous colitis, yotsimikizika colonoscopic ndi / kapena histologically, pakamwa pa vancomycin ndi metronidazole akuwonetsedwa.

Kawirikawiri tendonitis yomwe imachitika kawirikawiri imatha kubweretsa kupindika kwa tendons (makamaka Achilles tendon), makamaka kwa okalamba. Panthawi ya chizindikiro cha tendonitis, ndikofunikira kusiya mankhwalawa, kuyambitsa tendon ya Achilles ndikufunsira wamankhwala.

Panthawi yamankhwala, Mowa sayenera kuwamwa.

Mukamagwiritsa ntchito mankhwalawa, azimayi saloledwa kugwiritsa ntchito mankhwala aukhondo chifukwa chochulukitsidwa.

Poyerekeza ndi zamankhwala, kukulitsa njira ya myasthenia gravis, kuukira kwa porphyria pafupipafupi kwa odwala kumatheka.

Zitha kubweretsa zotsatira zabodza pakuwunika kwa chifuwa chachikulu cha chifuwa chachikulu (kumaletsa kumasulidwa kwa chifuwa chachikulu cha chifuwa chachikulu cha mycobacterium).

Odwala omwe ali ndi vuto la chiwindi kapena impso, kuwunika kwa plloma ndikofunikira. Mwa kuperewera kwambiri kwaimpso ndi kwa hepatic, chiopsezo cha zotsatira za poizoni chimawonjezeka (kuchepetsa kusintha kwa mankhwala kumafunika).

Mu ana, amagwiritsidwa ntchito pokhapokha ngati akuopseza moyo, poganizira za zovuta zamankhwala zomwe zingachitike ndikuwopsa kwa zotsatira zoyipa, pomwe nkosatheka kugwiritsa ntchito mankhwala ena, ochepera poizoni. Mlingo watsiku ndi tsiku pafupifupi mu nkhani iyi ndi 7.5 mg / kg, mulingo wake ndi 15 mg / kg.

Pa chithandizo ndi Ofloxin 200, chisamaliro chikuyenera kuthandizidwa poyendetsa magalimoto ndi kuchita zina zomwe zingakhale zoopsa zomwe zimafunikira chidwi chachikulu komanso kuthamanga kwa zochitika zama psychomotor.

Mlingo

200 mg mapiritsi okhala ndi mafilimu.

Piritsi limodzi lili

ntchito yogwira - ofloxacin 200,00 mg

zokopa: lactose monohydrate 95.20 mg, chimanga wowuma 47.60 mg, povidone 25 - 12,00 mg, crospovidone 20.00 mg, poloxamer 0.20 mg, magnesium stearate 8,00 mg, talc 4.00 mg

makanema ojambula: hypromellose 2910/5 - 9.42 mg, polyethylene glycol 6000 - 0,53 mg, talc 0.70 mg, titanium dioxide (E171) - 2.35 mg

Mapiritsi okhala ndi mawonekedwe, biconvex, wokutidwa ndi filimu, yoyera kapena pafupifupi yoyera, wokhala ndi chiopsezo chophwanya mbali imodzi ya piritsi ndi chizindikiro "200" mbali inayo.

Mankhwala

Mafuta pambuyo kumeza mwachangu komanso mwathunthu. Kuzindikira kwakukulu mu plasma ya magazi kumatheka mkati mwa maola 1-3 mutatha kamodzi kwa 200 mg. Kutha kwa theka-moyo ndi maola 4-6 (ngakhale mutamwa).

Polephera aimpso, mlingo uyenera kuchepetsedwa.

Palibe kuyanjana kwakukulu ndi chakudya komwe kunapezeka.

Mankhwala

Ofloxacin ndi antibacterial mankhwala a gulu la quinolone, omwe ali ndi bactericidal. Njira yayikulu yogwirira ntchito ndiyo kusokoneza kwenikweni kwa puloteni ya michere ya DNA gyrase. Mapulogalamu ena a DNA gyrase ndi omwe amaphatikizanso kufalitsa, kupanga, kukonza, kukonza. Kuletsa kwa michere ya DNA gyrase kumatsogolera pakukutitsa ndi kufalitsa kwa bakiteriya ndipo kumayambitsa kufa kwa ma cell mabakiteriya.

Antibacterial chiwonetsero cha chidwi cha tizilombo tosokoneza bongo toloxacin.

Ma tizilombo tating'ono tomwe timayang'ana ku ofloxacin: Staphylococcusaureus(kuphatikiza ndi methicillinStaphylococci),Staphylococcuskhungu,Neisseriamitundu,Esherichiacoli,Cikonokomacter,Klebsiella,Enterobacter,Hafnia,Proteus(kuphatikiza indole-positive ndi indole-negative),Haemophilusfuluwenza,Chlamydie,Legionella,Gardnerella.

Ma microorganic omwe ali ndi kuthekera kosiyanasiyana kwa ofloxacin: Streptococci,Serratiamarcescens,PseudomonasaeruginosandiMycoplasmas.

Ma Microorganisms kugonjetsedwa (osasangalatsa) kwa ofloxacin: mwachitsanzo Mabakiteriyamitundu,Eubacteriummitundu,Fusobacteriummitundu,Peptococci,Peptostreptococci.

Mlingo ndi makonzedwe

Mkati, mphindi 30-60 musanadye, osambitsidwa ndi madzi pang'ono, kwa akuluakulu - 200-400 mg 2 kawiri pa tsiku, kapena 400-800 mg 1 nthawi patsiku, Inde - masiku 7-10. Mlingo watsiku ndi tsiku ndi 200-800 mg. Ngati chiwindi chayamba kugwira ntchito - osapitirira 400 mg, mlingo umadalira Cl creatinine: ndi Cl 20-50 ml / mphindi, mlingo woyamba ndi 200 mg, ndiye 100 mg maola 24 aliwonse, ndi Cl yochepera 20 ml / min ya mlingo woyamba ndi 200 mg, ndiye 100 mg maola 48 aliwonse

Kwa ana (nkhani yadzidzidzi), kuchuluka kwa tsiku ndi tsiku ndi 7.5 mg / kg thupi (osapitirira 15 mg / kg).

Njira zopewera kupewa ngozi

Kuzilingalira kuyenera kuperekedwa kuti kuchepa kwamachitidwe azigawo (komwe kumayendetsedwa mosamala poyendetsa magalimoto). Mu ana, kugwiritsa ntchito kumatheka pokhapokha ngati zochitika zochiritsira zikuyembekezeka kwambiri.

Chenjezo uyenera kuikidwa pa matenda a ubongo.

Gulu la mankhwala

Omwe amathandizira pakugwiritsa ntchito kwadongosolo. Fluoroquinolones. Khodi ya PBX ndi J01M A01.

• Kukweza ndi kutsitsa kwamkodzo thirakiti
• matenda kupuma thirakiti
• matenda a pakhungu ndi minofu yofewa,
• gonorrhea wosavuta wa urethra ndi khomo lachiberekero,
• sanali gonococcal urethritis ndi cervicitis.

Zotsatira zoyipa

Pa khungu ndi subcutaneous minofu: kuyabwa, zotupa, urticaria, matuza, kutupa, hyperhidrosis, pustular totupa, erythema multiforme, mtima ,ura, Stevens-Johnson, tsamba la Lyell, pachimake kwambiri pantulosis, photosensitivity, hypersensitivity mu mawonekedwe kusintha kwa khungu kapena kutulutsa misomali.

Pa mbali ya chitetezo chamthupi: zochita za hypersensitivity, kuphatikizapo anaphylactic / anaphylactoid zimachitika, angioedema (kuphatikizapo kutupa kwa lilime, larynx, pharynx, kutupa / kutupa kwa nkhope), anaphylactic / anaphylactoid. Anaphylactic / anaphylactoid zimachitika mu nthawi ya makonzedwe a ofloxacin, kuphatikizapo zizindikiro za anaphylaxis, tachycardia, kutentha thupi, kufupika, nkhawa, angioedema, vasculitis, komwe mwapadera kungayambitse necrosis, eosinophilia. Pankhaniyi, kugwiritsa ntchito mankhwalawa kuyenera kusiyidwa ndipo njira zina zochiritsira ziyenera kuyambitsidwa.

Kuchokera kumbali ya mtima dongosolo: tachycardia, yochepa yocheperako hypotension, kugwa (pakachitika kwambiri ochepa hypotension, mankhwalawa ayenera kuyimitsidwa) kwamitsempha yamagazi, flutter-ventricular fiber .

Kuchokera kumachitidwe amanjenje: mutu, chizungulire, kukhumudwa, kusokonezeka kwa tulo, kugona, kugona, kuda nkhawa, kukhumudwa, kusokonezeka, kugona, kugona pang'ono, kuchepetsa kuthana ndi zomwe zimachitika, kuchuluka kwazovuta zam'mimba, paresthesia, sensor kapena sensorimotor neuropathy Zizindikiro zina za extrapyramidal, kusokonezeka kwa minofu (kusalinganika, kusakhazikika), malingaliro ochitika, malingaliro odzipha / zochita, kuyerekezera zinthu zina.

Kuchokera mmimba thirakiti: anorexia, nseru, kusanza, m'mimba kapena kupweteka, kutsegula m'mimba, enterocolitis, nthawi zina hemorrhagic enterocolitis, flatulence dysbiosis, pseudomembranous colitis.

Hepatobiliary dongosolo: kuchuluka kwa chiwindi michere ndi bilirubin, cholestatic jaundice, hepatitis.

Kuchokera kwamikodzo dongosolo: aimpso kulephera ndi kuwonjezeka urea, creatinine pachimake aimpso kulephera, pachimake interstitial nephritis.

Kuchokera ku minculoskeletal system: tendonitis, kukokana, myalgia, arthralgia, kupindika kwa minofu, kupindika kwa tendon (kuphatikiza Achilles tendon), komwe kumatha kuchitika patatha maola 48 atayamba kugwiritsa ntchito ofloxacin ndipo amatha kukhala apakati, rhabdomyolysis ndi / kapena myopathy kufooka kwa minofu.

Kumbali ya magazi ndi zamitsempha yamagazi dongosolo: neutropenia, leukopenia, kuchepa magazi, hemolytic kuchepa magazi, eosinophilia, thrombocytopenia, pancytopenia agranulocytosis, kuletsa mafupa hematopoiesis.

Kuchokera ku ziwalo zam'maganizo: kuzimitsa maso, vertigo, masomphenya owonongeka, kulawa, kununkhira, Photophobia, tinnitus, kumva.

Kuchokera kupuma dongosolo: chifuwa, nasopharyngitis, kupuma movutikira, bronchospasm, chifuwa cha matumbo, chifuwa chachikulu.

Matenda a Metabolic: hypoglycemia kapena hyperglycemia (odwala matenda a shuga mellitus).

Matenda: fungal matenda, candidiasis, kukana tizilombo toyambitsa matenda.

Zina: kuvulala kwamatenda a porphyria odwala porphyria, malaise, kutopa.

Gwiritsani ntchito pa nthawi yoyembekezera kapena mkaka wa m'mawere

Ofloxacin amatsutsana mwa azimayi pa nthawi yoyembekezera komanso mkaka wa m'mawere chifukwa chosadziwa zambiri ndi mankhwalawa. Kupezeka kwa Ofloxacin mkaka wa m'mawere ndikofunikira.

Ngati mukufunika kugwiritsa ntchito mankhwalawa, kuyamwitsa kuyenera kuyimitsidwa kwa nthawi yayitali.

Mankhwalawa ali contraind mu ana ndi achinyamata.

Zolemba zogwiritsira ntchito

Musanayambe chithandizo, ndikofunikira kuchita mayeso: chikhalidwe pa microflora ndi kutsimikiza kwa toloxacin.

Mukamagwiritsa ntchito ofloxacin, ndikofunikira kuti pakhale mpweya wokwanira. Odwala ndi mkhutu aimpso ndi kwa chiwindi ntchito, mankhwala ayenera kutumikiridwa mosamala ndi kuyanʻanila magawo a chiwindi ndi impso ntchito. Kwa odwala omwe ali ndi vuto la impso, mlingo wa ofloxacin umayenera kusinthidwa, ngati akuchedwa kuti amasulidwe.

Ngati chiwindi chimalephera kugwira ntchito, aloxacin amagwiritsidwa ntchito mosamala chifukwa chokwanira cha vuto la chiwindi. Kwa fluoroquinolones, milandu ya hepatitis yokwanira imanenedwa, ikhoza kuyambitsa kulephera kwa chiwindi (asanafe). Lekani kulandira chithandizo chamankhwala ndikufunsani kwa dokotala ngati zikuwoneka ndi zizindikiro za matenda a chiwindi, monga anorexia, jaundice, mkodzo wakuda, kuyabwa, komanso m'mimba.

Matenda oyambitsidwa ndi Clostridium Hardile. Kutsekula m'mimba, makamaka koopsa, kosasunthika, kapena kusakanikirana ndi magazi, munthawi ya mankhwala a orloxacin kapena pambuyo pathupi lawo limatha kukhala chizindikiro cha pseudomembranous colitis. Ngati pseudomembranous colitis ikukayikiridwa, ofloxacin iyenera kuchotsedwa nthawi yomweyo ndipo mankhwala oyenera a antibayotiki ayenera kuyambitsidwa mosataya nthawi (mwachitsanzo, vancomycin, teyplanin kapena metronidazole). Panthawi imeneyi, mankhwala omwe amapondereza matumbo amayambitsidwa.

Hypersensitivity ndi thupi lawo siligwirizana ndi fluoroquinolones adanenedwa pambuyo pa kugwiritsidwa ntchito koyamba. Maganizo a anaphylactic ndi anaphylactoid amatha kudabwitsidwa, ndiwopseza moyo, ngakhale atangoyamba kugwiritsa ntchito. Pankhaniyi, ofloxacin iyenera kusiyidwa ndikuthandizidwa koyenera.

Odwala omwe amatenga ofloxacin ayenera kupewa kuwonekera ndi kuwala kwa UV (mabedi osenda) chifukwa cha kuthekera kwa photosensitivity. Ngati mawonekedwe a photosensitivity (mwachitsanzo, ofanana ndi kutentha kwa dzuwa), mankhwala a ofloxacin ayenera kusiyidwa.

Zovuta za sensorimotor zotumphukira neuropathy zalembedwa mu odwala akutenga fluoroquinolones, kuphatikizapo ofloxacin. Ndi chitukuko cha neuropathy, ofloxacin iyenera kusiyidwa.

Panthawi yakukhudzana kwambiri ndi vuto lakelo, kugwiritsa ntchito mankhwalawa kuyenera kusiyiratu.

Kutalika kwa QT. Mukamamwa fluoroquinolones, milandu yachilendo kwambiri ya kutalika kwa nthawi ya QT yanenedwapo. Chenjezo liyenera kuchitika mukamatenga fluoroquinolones, kuphatikizapo ofloxacin, mu odwala omwe ali ndi chiopsezo chokwanira kutalikitsa kwa nthawi ya QT, odwala okalamba, omwe ali ndi vuto la kukondera kwa electrolyte (hypokalemia, hypomagnesemia), kubadwa kwatsopano kapena kutalika kwa nthawi yayitali ya QT, matenda a mtima (kulephera kwa mtima, kulowetsedwa kwa mtima, bradycardia).

Tendonitis. Nthawi zina, chithandizo chokhala ndi quinolones chimatha kupangitsa tendonitis, yomwe ingayambitse kupindika kwa tendons, kuphatikizapo Achilles tendon. Odwala a chilimwe amatengeka kwambiri ndi tendonitis. Kuopsa kwa kupindika kwa tendon kumatheka chifukwa chamankhwala omwe amapezeka ndi corticosteroids. Ngati tendinitis ikukayikiridwa kapena chizindikiro choyambirira cha kupweteka kapena kutupa, kuoneka kwa chithandizo cha ofloxacin kuyenera kuyimitsidwa nthawi yomweyo ndikuchita zoyenera zotengedwa (mwachitsanzo, kuonetsetsa kuti immobilization)

Odwala ndi mkhutu chapakati mantha dongosolo, ndi matenda amisempha, ndi matenda amisala kapena mbiri ya ofloxacin ayenera kuikidwa mosamala.

Odwala matenda ashuga, ofloxacin angayambitse kuchuluka kwa hypoglycemic zotsatira za insulin, pakamwa antidiabetesic mankhwala (kuphatikizapo glibenclamide). Odwala awa ayenera kuyang'anira shuga wawo wamagazi.

Ndi chithandizo cha mankhwala opatsirana kwa nthawi yayitali kapena mobwerezabwereza, matenda opatsirana mwakulitsa komanso kukula kwa tizilombo toyambitsa matenda ndizotheka. Ndikakulitsa matenda opatsirana yachiwiri, njira zoyenera ziyenera kuchitidwa.

Mankhwalawa ndi mankhwala aloxacin, monga mankhwala ena a gululi, kulimbana kwa zovuta zina za Pseudomonas aeruginosa kumatha msanga.

Ofloxacin si mankhwala osankhira chithandizo cha chibayo chifukwa cha chibayo kapena mycoplasmas, kapena tillillitis wa tillillitis chifukwa cha β-hemolytic streptococci.

Pa mankhwala sayenera kumwa zakumwa zoledzeretsa.

Ofloxacin ndi mankhwala mosamala odwala omwe ali ndi mbiri ya myasthenia gravis.

Odwala omwe akutenga mavitamini a vitamini K amayang'anira kuwunika kwa magazi akamamwa antloxacin ndi mavitamini a vitamini K (warfarin) kudzera pachiwopsezo chowonjezereka cha coagulation wamagazi (nthawi ya prothrombin) ndi / kapena magazi.

Mankhwala ali ndi lactose, chifukwa chake, odwala omwe ali ndi mtundu wina wa galactose osalolera, kuperewera kwa lactase kapena glucose-galactose malabsorption sayenera kugwiritsa ntchito mankhwalawa.

Kutha kukopa momwe zinthu zikuyendera mukamayendetsa magalimoto kapena njila zina

Pankhani ya zovuta zamtundu wamanjenje, ziwalo zamasomphenya, tikulimbikitsidwa kupewa kuyendetsa magalimoto kapena kugwira ntchito ndi makina.

Kuyanjana ndi mankhwala ena ndi mitundu ina yoyanjana.

Ndi munthawi yomweyo makonzedwe a ofloxacin omwe ali ndi antihypertensive othandizira, kuchepa kwakukulu kwa magazi kumatheka. Zikatero, ngati ofloxacin amagwiritsidwa ntchito ngati mankhwala opha ziwopsezo ndi barbiturates, ndikofunikira kuyang'anira ntchito ya mtima.

Amaphatikizidwa kugwiritsa ntchito mankhwala aloxacin nthawi imodzi ndi mankhwala omwe amatenga nthawi ya QT (kalasi IA antiarrhythmic mankhwala - quinine, procainamide ndi kalasi III - amiodarone, sotalol, antidepressants, ma macrolides).

Kugwiritsa ntchito munthawi yomweyo mankhwala aloxacin omwe ali ndi mankhwala osagwiritsa ntchito mankhwala a antiquidal (kuphatikizapo zotumphukira za propionic acid), zotumphukira za nitroimidazole ndi methylxanthines zimawonjezera chiopsezo cha zotsatira za nephrotoxic, kutsitsa kugunda, komwe kungayambitse kukulitsa kulanda.

Kukhazikika kwa munthawi yomweyo kwa ofloxacin mu Mlingo waukulu wokhala ndi mankhwala omwe amamasulidwa ndi katulutsidwe koyambira kungapangitse kuchuluka kwa plasma chifukwa chakuchepa kwa zomwe akutulutsa.

Popeza kugwiritsa ntchito mitundu yambiri ya quinolones, kuphatikiza ofloxacin, kumalepheretsa ntchito ya cytochrome P450, munthawi yomweyo kugwiritsa ntchito mankhwala aloxacin omwe amakhala ndi mankhwalawa (cyclosporine, theophylline, methylxanthine, caffeine, warfarin) amatalikitsa theka la moyo wa mankhwalawa.

Ndi munthawi yomweyo makonzedwe a ofloxacin ndi olimbana ndi vitamini K, ndikofunikira kuyang'anira kayendedwe ka magazi konse.

Kugwiritsa ntchito munthawi yomweyo mankhwala omwe ali ndi maantacid okhala ndi calcium, magnesium kapena aluminium, wokhala ndi sucralfate, wokhala ndi chitsulo kapena kuyikira chitsulo, wokhala ndi multivitamini wokhala ndi zinc, amachepetsa kuyamwa kwa ofloxacin. Chifukwa chake, kuphatikiza pakati pa kumwa mankhwalawa kuyenera kukhala osachepera 2:00.

Ndi munthawi yomweyo kugwiritsa ntchito ofloxacin ndi pakamwa hypoglycemic wothandizila ndi insulin, hypoglycemia kapena hyperglycemia ndikotheka. Chifukwa chake, ndikofunikira kuyang'anira magawo kuti awalipire. Pogwiritsa ntchito munthawi yomweyo ndi glibenclamide, kuwonjezereka kwa glibenclamide mu plasma yamagazi ndikotheka.

Mukamagwiritsidwa ntchito ndi mankhwala omwe amcherekitsa mkodzo (carbonic anhydrase inhibitors, citrate, sodium bicarbonate), chiopsezo cha crystalluria ndi zotsatira za nephrotic zimawonjezeka.

Kugwiritsa ntchito munthawi yomweyo mankhwala aloxacin omwe ali ndi phenenecid, cimetidine, furosemide, methotrexate kumabweretsa kuwonjezeka kwa kuchuluka kwa ofloxacin m'madzi a m'magazi.

Panthawi yofufuza. Mankhwalawa ndi ofloxacin, zotsatira zoyipa zabodza zimatha kuwonedwa posankha ma opiates kapena porphyrins mu mkodzo. Chifukwa chake, ndikofunikira kugwiritsa ntchito njira zina.

Ofloxacin ikhoza kulepheretsa kukula kwa chifuwa chachikulu cha Mycobacterium ndikuwonetsa zotsatira zabodza mu kafukufuku wa bacteriological kuti adziwe chifuwa chachikulu.