Analogs a ampoules Berlition 300

Dzina la malonda akukonzekera: Berlithion

Dongosolo losavomerezeka: Thioctic acid

Fomu ya Mlingo: Mapiritsi, makapisozi, ma apulo.

Chithandizo: Thioctic acid

Gulu la Pharmacotherapeutic: Wothandizira.

Mali a Berlition amaphatikiza monga mankhwala ena ophatikizira thioctic acid (alpha-lipoic acid) osakanikirana ndi mchere wa ethylene diamine, womwe ndi antioxidant wamkati womwe umamanga ma radicals aulere ndi coenzyme ya alpha-keto acid decarboxylation process.

Mankhwalawa ndi Berlition amathandizira kuchepetsa kuchuluka kwa shuga m'magazi a plasma ndikuwonjezera kuchuluka kwa hepatic glycogen, kufooketsa kukana kwa insulin, kumalimbikitsa cholesterol, kuyang'anira lipid ndi metabolism ya carbohydrate. Thioctic acid, chifukwa cha ntchito yake yotsutsana ndi antioxidant, imateteza maselo a thupi la munthu ku kuwonongeka komwe kumachitika chifukwa cha zinthu zawo zowola.

Odwala omwe ali ndi matenda a shuga, thioctic acid amachepetsa kumasulidwa kwa mapuloteni a glycation kumapeto kwa mitsempha, kumachulukitsa ma cellcirculation ndikuwongolera kuthamanga kwa magazi, ndikuwonjezera kuchuluka kwa thupi kwa glutathione antioxidant. Chifukwa chakuchepetsa mphamvu ya shuga m'magazi a plasma, imakhudza njira yina ya kagayidwe kake.

Thioctic acid amachepetsa kudzikundikira kwa ma metabolic a polyol metabolites, potero amathandizira kuchepetsa kutupira kwa minofu yamanjenje. Limatulutsa kutsika kwa mitsempha kukakamira ndi mphamvu kagayidwe. Kuchita nawo mafuta kagayidwe, kumachulukitsa biosynthesis ya phospholipids, chifukwa chomwe mawonekedwe owonongeka a zimagwira ma cell amasinthidwa. Amathetsa zovuta zakumwa zochokera ku zakumwa zochokera ku mowa (pyruvic acid, acetaldehyde), amachepetsa kutulutsidwa kwakukulu kwa mamolekyulu a okosijeni, amachepetsa ischemia ndi endoneural hypoxia, kuchepetsa mawonekedwe a polyneuropathy, owonetsedwa mu mawonekedwe a paresthesias, moto woyaka, dzanzi ndi kupweteka m'malire.

Kutengera ndi zomwe tafotokozazi, thioctic acid imadziwika ndi hypoglycemic, neurotrophic ndi antioxidant ntchito, komanso machitidwe omwe amakongoletsa metabolid ya lipid. Kugwiritsa ntchito pophika kwa mchere wa ethylenediamine pakukonzanso kumachepetsa kuopsa kwa zovuta zoyipa za thioctic acid.

Mukamamwa pakamwa, thioctic acid imatengedwa mwachangu komanso kumamwa kwathunthu kuchokera kumimba (chakudya chomwe chimayatsidwa limodzi zimachepetsa mayamwidwe mwanjira ina). TCmax mu plasma imasiyanasiyana pakati pa 25-60 Mphindi (iv. Ya 10-mphindi 10). Plasma Cmax ndi 25 38 mcg / ml. Bioavailability pafupifupi 30%, Vd pafupifupi 450 ml / kg, AUC pafupifupi 5 μg / h / ml.

Thioctic acid imayamba kugwira ntchito “yoyamba kudutsa” kudzera pachiwindi. Kupatula kwa zinthu za metabolic kumakhala kotheka chifukwa cha kuphatikizika ndi makupidwe a oxidation a unyolo wam'mbali. Kupereka mawonekedwe mu mawonekedwe a metabolites ndi 80-90% yochitidwa ndi impso. T1 / 2 imatenga pafupifupi mphindi 25. Chilolezo chonse cha plasma ndi 10-15 ml / min / kg.

Zisonyezero zogwiritsidwa ntchito:

Mankhwala Berlition amagwiritsidwa ntchito makamaka pothandizira odwala omwe ali ndi matenda ashuga komanso mowa wambiri, omwe amaphatikizidwa ndi paresthesia. Mankhwala atha kuperekedwa kwa odwala matenda a chiwindi osiyanasiyana.

Zoyipa:

Berlition sinafotokozeredwe kwa odwala omwe ali ndi hypersensitivity kuti alpha-lipoic acid ndi magawo ena a mankhwala.

Ana osakwana zaka 18, komanso amayi apakati ndi oyamwitsa, osavomerezeka kuti apereke mankhwala Berlition.

Mapiritsi a Berlition 300 Oral sagwiritsidwa ntchito pochiza odwala omwe ali ndi vuto la shuga - galactose, kuchepa kwa lactase ndi galactosemia.

Makapisozi a Berlition samalimbikitsidwa kwa odwala omwe ali ndi tsankho la fructose.

Mankhwala amathandizidwa mosamala odwala matenda a shuga (kuyang'anira glycemia ndikofunikira).

Mogwirizana ndi mankhwala ena:

Ndi zoletsedwa kugwiritsa ntchito mowa wa ethyl panthawi ya mankhwala ndi Berlition.

Alpha lipoic acid amachepetsa mphamvu ya chisplatin ikagwiritsidwa ntchito palimodzi.

Mankhwala amatha kupititsa patsogolo mphamvu za othandizira a hypoglycemic. Popereka mankhwala, odwala matenda ashuga ayenera kuyang'anitsitsa shuga wamagazi awo, ndipo ngati ndi kotheka, asinthe mankhwala a antidiabetes.

Thioctic acid imapanga zinthu zovuta ndi calcium, komanso zitsulo, kuphatikizapo magnesium ndi chitsulo. Kuvomerezeka kwa mankhwala okhala ndi zinthuzi, komanso kugwiritsa ntchito zinthu zamkaka sikuloledwa kupitirira maola opitilira 6-8 mutatha kumwa Berlition.

Mlingo ndi makonzedwe:

Makapisozi okhala ndi mapiritsi:

Cholinga cha pakamwa. Sizoletsedwa kupera kapena kutafuna makapisozi ndi mapiritsi. Mlingo wa tsiku ndi tsiku wa thioctic acid umayikidwa nthawi imodzi, tikulimbikitsidwa kumwa mankhwalawa mphindi 30 asanadye m'mawa. Kuti mukwaniritse zofunikira zochizira, muyenera kutsatira malangizo omwe mungamwe mankhwalawo. Mankhwala nthawi zambiri amatengedwa kwa nthawi yayitali, njira ya chithandizo imatsimikiziridwa ndi adokotala.

Akuluakulu odwala matenda ashuga polyneuropathy nthawi zambiri amalimbikitsidwa kuti atenge 600 mg wa thioctic acid (mapiritsi 2 a mankhwala Berlition Orral kapena 2 makapisozi a mankhwala Berlition 300 kapena 1 kapisozi wa mankhwala Berlition 600) patsiku.

Akuluakulu omwe ali ndi matenda a chiwindi nthawi zambiri amalimbikitsidwa kuti apereke mankhwala a 600-1200 mg a thioctic acid patsiku.

Mu matenda akulu, tikulimbikitsidwa kuti muyambe kugwiritsa ntchito mankhwala osokoneza bongo pogwiritsa ntchito mitundu ya makolo.

Tsatirani njira yothetsera kulowetsedwa:

Zomwe zili zowonjezera zakonzedwera kukonzekera kulowetsedwa. Monga chosungunulira, yankho la 0.9% sodium chloride yokha ndi yomwe imaloledwa. Njira yotsirizidwa imaperekedwa kudzera m'mitsempha, kutseka botolo ndi zojambula zotayidwa kuti zisawonongeke ndi dzuwa. 250 ml yankho lomalizidwa liyenera kuperekedwa kwa mphindi zosachepera 30.

Akuluakulu omwe ali ndi vuto la matenda ashuga polyneuropathy nthawi zambiri amalimbikitsidwa kupereka mankhwala 300-600 mg wa thioctic acid (1-2 ampoules ya mankhwala Berlition 300 kapena 1 ampoule wa mankhwala a Berlition 600) patsiku.

Akuluakulu omwe ali ndi mitundu yayikulu ya matenda a chiwindi nthawi zambiri amalimbikitsidwa kuti apereke mankhwala a 600-1200 mg a thioctic acid patsiku.

Therapy ndi parenteral mitundu ya mankhwala ikuchitika osaposa masabata 2-4, pambuyo pake amasintha pakamwa pioctic acid.

Ndi kulowetsedwa kwa mankhwalawa, pamakhala chiopsezo cha anaphylactic, pakayamba kuyabwa, kufooka kapena nseru, mankhwalawa amayenera kuyimitsidwa nthawi yomweyo. Pa kulowetsedwa, wodwalayo amayenera kuyang'aniridwa nthawi zonse ndi ogwira ntchito kuchipatala.

Odwala omwe ali ndi matenda ashuga polyneuropathy ayenera kukhalabe ndi kuchuluka kwa shuga m'magazi (kuphatikiza, ngati kuli koyenera, kusintha mankhwala a hypoglycemic).

Malangizo apadera: Odwala omwe ali ndi matenda ashuga omwe amamwa mankhwala a hypoglycemic kapena mankhwala a insulin panthawi ya mankhwala a Berlition amafunika kuwunika pafupipafupi kuchuluka kwa shuga wa m'magazi (makamaka kumayambiriro kwa chithandizo) ndipo, ngati kuli koyenera, sinthani (kuchepetsani) mlingo wa mankhwala a hypoglycemic.

Mukamagwiritsa ntchito jekeseni wa Mlingo wa Berlition, zimachitika kuti hypersensitivity phenomena izipezeka. Pankhani ya zizindikiro zoyipa, zokhala ndi kuyabwa, malaise, nseru, makonzedwe a Berlition ayenera kuyimitsidwa nthawi yomweyo.

Berlition mwatsopano wakonzedwa kulowetsedwa njira ayenera kutetezedwa kuti padzuwa.

Popereka mankhwala a Berlition, dokotala ayenera kuganizira zomwe zakonzedwa mu lactose mu mawonekedwe awa, zomwe zingakhale zofunikira kwa odwala omwe ali ndi vuto la shuga.

Zotsatira zoyipa:

Kuchokera pa ngalande ya alimentary: nseru, kusanza, kusokonezeka kwa tulo, zizindikiro za dyspeptic, kusintha kwa zomverera.

Pa mbali ya chapakati ndi zotumphukira mantha dongosolo: pambuyo mwachangu mtsempha makonzedwe, chitukuko cha kumva kuwawa m'mutu, kupweteka ndi diplopia adadziwika.

Kuchokera pamtima: pambuyo pa kukhazikika kwa magazi mkati, kukhazikika kwa tachycardia, kufupika kwa nkhope ndi thupi lakumwambalo, komanso kupweteka ndi kumverera kwamphamvu m'chifuwa.

Thupi lawo siligwirizana: zotupa pakhungu, kuyabwa, urticaria, chikanga. Nthawi zina, makamaka pakukhazikitsa mlingo waukulu wa mankhwalawa, kuwopsa kwa anaphylactic ndikotheka.

Ena: Zizindikiro za hypoglycemia zimatha kupezeka, thukuta kwambiri, mutu, kuwonongeka kwa mawonekedwe, komanso chizungulire. Nthawi zina, pogwiritsa ntchito thioctic acid, kupuma movutikira, thrombocytopenia, ndi purpura adadziwika.

Kumayambiriro kwa mankhwala othandizira odwala omwe ali ndi polyneuropathy, pakhoza kukhala kuwonjezeka kwa paresthesia ndikumverera kwa "tsekwe".

Bongo

Kutenga Mlingo waukulu wa Berlition kumatha kudzetsa mutu, nseru, ndi kusanza. Ndi kuwonjezereka kwa mlingo, kusokonezeka ndi kukoka kwa psychomotor kumayamba. Kulandila kwa oposa 10 g a alpha-lipoic acid kumatha kubweretsa kuledzera kwambiri, kuphatikizapo imfa. Kuopsa kwa poizoni wa alpha-lipoic acid kumatha kuwonjezeka ndi kuphatikiza kwa mankhwala Berlition ndi ethyl mowa. Ndi kuledzera kwambiri ndi thioctic acid, odwala adazindikira kukula kwa kukomoka kwakukulu, lactic acidosis, kutsika magazi, hemolysis, rhabdomyolysis, kutsika kwa ntchito m'mmafupa, komanso kugawa intravascular coagulation, ziwalo zingapo ndikulephera.

Palibe mankhwala enieni. Mukamamwa mankhwala ambiri, mumagonekedwa kuchipatala. Ngati poyizoni ndi pakamwa mitundu ya mankhwala, chapamimba thonje ndi makonzedwe a enterosorbents ndi mankhwala. Pankhani ya mankhwala osokoneza bongo Berlition, kwambiri mankhwala tikulimbikitsidwa, ndipo symptomatic mankhwala imachitikanso ngati zikuonetsa.

Kuchita bwino kwa hemodialysis ndi hemofiltration ngati poizoni wa alpha-lipoic acid sunaphunzire.

Tsiku lotha ntchito:

Tsatirani njira yothetsera kulowetsedwa ndioyenera zaka 3. Okonzeka yankho la kulowetsedwa ndioyenera maola 6.

Mapiritsi okhala ndi mbali, Berlition 300 Oral ndi oyenera zaka 2.

Makapisozi a Berlition 300 ndi oyenera zaka 3, makapisozi a Berlition 600 ndi oyenera zaka 2,5.

Zoyenera kufalitsa kuchokera ku malo ogulitsa mankhwala: Ndi mankhwala.

Wopanga: Jenahexal Pharma, Pharma Jena GmbH, Haupt Pharma Wolfratshausen (Germany)

Analogs a mankhwala Berlition 300

Analogue ndiyotsika mtengo kuchokera ku ma ruble 162.

Oktolipen ndimakonzedwe a piritsi kutengera thioctic acid. Amawonetsedwa pa ntchito ya matenda ashuga polyneuropathy ndi uchidakwa polyneuropathy. Oktolipen sanakhazikitsidwe asanafike zaka 18, panthawi yoyembekezera komanso yoyamwitsa.

Analogue ndiotsika mtengo kuchokera ku ma ruble 448.

Lipoic acid - analogue yotsika mtengo ya mankhwala a Berlition 300, okhala ndi lipoic kapena thioctic acid, mu gawo la 25 mg pa piritsi. Amakhala ndi mavitamini okhala ndi mankhwala, amakhala ndi antioxidant kwambiri mthupi, amasintha ntchito ya chiwindi, amakhala ndi mphamvu ya insulin. Osavomerezeka kuti agwiritsidwe ntchito ndi mowa.

Analogue ndiotsika mtengo kuchokera ku ma ruble 187.

Wopanga: Biosynthesis (Russia)
Kutulutsa Mafomu:

• Conc. amp. 30 mg / ml, 10 ml, ma PC 10., Mtengo kuchokera ku ma ruble 308

Marbiopharm (Russia) Lipoic acid - analogue yotsika mtengo ya mankhwala a Berlition 300, okhala ndi lipoic kapena thioctic acid, mu gawo la 25 mg piritsi. Amakhala ndi mavitamini okhala ndi mankhwala, amakhala ndi antioxidant kwambiri mthupi, amasintha ntchito ya chiwindi, amakhala ndi mphamvu ya insulin. Osavomerezeka kuti agwiritsidwe ntchito ndi mowa.

Analogue ndiyotsika mtengo kuchokera ku ma ruble 124.

Marbiopharm (Russia) Lipoic acid - analogue yotsika mtengo ya mankhwala a Berlition 300, okhala ndi lipoic kapena thioctic acid, mu gawo la 25 mg piritsi. Amakhala ndi mavitamini okhala ndi mankhwala, amakhala ndi antioxidant kwambiri mthupi, amasintha ntchito ya chiwindi, amakhala ndi mphamvu ya insulin. Osavomerezeka kuti agwiritsidwe ntchito ndi mowa.

Zotsatira zoyipa za Berlition

Njira yothetsera jakisoni: Nthawi zina kumva kuwawa m'mutu komanso kupuma movutikira (mwachangu / pa makonzedwe). Thupi lawo siligwirizana n`zotheka pa jekeseni malo ndi kuwoneka urticaria kapena moto moto. Nthawi zina, kukomoka, diplopia, kutulutsa zotupa pakhungu ndi mucous nembanemba.

Mapiritsi okhala ndi mbali: Nthawi zina, khungu limasokoneza.

Kutsika kwa shuga m'magazi ndikotheka.

Dzina lathunthu: Berlition 300, ampoules

Dzina la Brand:
Berlin-Chemie

Dziko Loyambira:
Germany

Mtengo: 448 r

Kufotokozera:

Berlition 300, ampoules 12 ml N5

Machitidwe

Hepatoprotective, hypolipidemic, hypocholesterolemic, hypoglycemic. Monga coenzyme ya mitochondrial multienzyme complexes, imatenga nawo oxidative decarboxylation wa pyruvic acid ndi alpha-keto acid. Zimathandizira kuchepetsa shuga m'magazi ndikuwonjezera glycogen m'chiwindi, komanso kuthana ndi insulin.
Mwa chikhalidwe cha zochita zamapangidwe amtundu, zimakhala pafupi ndi mavitamini a B. Amatenga nawo gawo la lipid ndi carbohydrate metabolism, imalimbikitsa kagayidwe ka cholesterol, ndikuwongolera ntchito ya chiwindi. Kugwiritsa ntchito trometamol mchere wa thioctic acid (osalowerera m'ndale) njira zothetsera zamitsempha kungathandize kuchepetsa zovuta zoyipa.

Pharmacokinetics:
Mukamamwa pakamwa, imathiridwa mwachangu komanso kwathunthu kuchokera m'mimba (kudya ndi chakudya kumachepetsa mayamwidwe). Nthawi yoti mufikire Cmax ndi mphindi 4060. Bioavailability ndi 30%. Ili ndi mphamvu ya "gawo loyamba" kudzera m'chiwindi. Kapangidwe ka metabolites kumachitika chifukwa cha kupendekeka kwa mbali ndi oxidation. Kuchuluka kwa magawidwe ndi pafupifupi 450 ml / kg. Njira zazikulu za metabolic ndi makutidwe ndi okosijeni ndi kulumikizana. Thioctic acid ndi metabolites ake amuchotsa impso (8090%). T1 / 2 - 2050 min. Kuchuluka kwa plasma Cl - 1015 ml / min.

Zowonetsa:
A shuga ndi mowa polyneuropathy, steatohepatitis osiyanasiyana etiologies, mafuta chiwindi, kuledzera.

Contraindication
:
Hypersensitivity, kutenga pakati, kuyamwitsa. Siyenera kulembedwa kwa ana ndi achinyamata (chifukwa cha kusowa kwazachipatala ndikugwiritsa ntchito mankhwalawa).

Gwiritsani ntchito pa nthawi yoyembekezera

Contraindified mu mimba. Panthawi ya chithandizo, kuyamwitsa kuyimitsidwa (palibe chidziwitso chokwanira ndi milandu iyi).

Zotsatira zoyipa:
Mapiritsi okhala ndi mbali: nthawi zina, khungu limasokoneza.
Kutsika kwa shuga m'magazi ndikotheka.

Mogwirizana:

Imafooketsa mphamvu ya cisplatin, imakweza mankhwala a hypoglycemic.

Bongo

Zizindikiro: mutu, nseru, kusanza.

Chithandizo:

symptomatic mankhwala. Palibe mankhwala enieni.

Mlingo ndi makonzedwe:

Kuchiza kuyenera kuyambira pa kukhazikitsa yankho la Berlition 300 IU kwa masabata 2-4. Pazomwezi, ma ampoules a 1-2 a kukonzekera (12-2 ml ya yankho), omwe amafanana ndi 300-600 mg wa alpha lipoic acid) amadziwitsidwa mu 250 ml ya thupi ndi 0,9% ya sodium chloride. Mtsogolomo, amasintha ndikuthandizira chithandizo cha nthawi yayitali ndi mankhwala Berlition 300 pamlomo monga mapiritsi a 300-600 mg / tsiku.

Chenjezo:
Pa mankhwala, munthu ayenera kupewa zakumwa zoledzeretsa (mowa ndi zinthu zake zimafooketsa chithandizo).
Mukamamwa mankhwalawa, muyenera kuyang'anira kuchuluka kwa shuga m'magazi (makamaka koyambirira kwa mankhwala). Nthawi zina, pofuna kupewa zizindikiro za hypoglycemia, pangafunikire kuchepetsa mlingo wa insulin kapena wothandizila kukamwa.

Mlingo Berlition

Mu / mu, mu. Woopsa mitundu ya mtsempha wamagazi polyneuropathy, 12- ml ml (300-600 mg wa alpha-lipoic acid) patsiku kwa masabata awiri. Mwa izi, ma ampoules a 1-2 a mankhwalawa amatsitsidwa mu 250 ml ya mphamvu ya 0,9% ya sodium kolorayidi ndipo amaperekedwa kwa mphindi pafupifupi 30. M'tsogolomu, amasintha kukonzanso mankhwala ndi Berlition 300 mwanjira ya mapiritsi a 300 mg patsiku.

Zochizira polyneuropathy - 1 tebulo. Nthawi 1-2 patsiku (300-600 mg wa alpha-lipoic acid).

1. Kulembetsa kwa State of Medic
2. Anatomical Therapeutic Chemical Classization (ATX),
3. Gulu la Nosological (ICD-10),
4. Malangizo ovomerezeka kuchokera kwa wopanga.

Zingati cardiomagnyl

Mtengo wa Yarina m'masitolo ogulitsa mankhwala

Mtengo wa Cytotec mu malo ogulitsa mankhwala

Berlition adagula kuti athandize ambiri. Zomverera zosasangalatsa zinali m'chiwindi. M'malo mwake, mankhwalawa amayeretsa thupi bwino, ndidazindikira kuti chiwindi chimayamba kugwira ntchito mwatsopano nditatha kutenga. Sindinapeze vuto lililonse. Ndili ndi matenda ashuga ndisadakhale ndi mavuto athunthu, koma mankhwalawa nditatha, ndinazindikira kusintha, kunenepa kunachepa. Mtengo wabwino wa mapiritsi.

Berlition amatenga nthawi zambiri, shuga amachitika mwachangu. Kenako pakubwera kuchepa pang'ono. Zinakhudza cholesterol, yomwe imandizuntsanso kwa zaka ndipo glucose inayamba kuchepa. Zachidziwikire, pambuyo pa chithandizo chotere chidayamba kukhala chosavuta. Sindinganene kuti mtengo wake ndiwodula, pakadali pano zonse zandikwanira. Ndinagula kangapo, ndikupitiliza kuilandira malinga ndi malangizo a dokotala.

Pakafukufuku wotsatira wa kuchipatala, ndidapeza kuti m'magazi anga mwayetsa magazi ambiri. Kunena kuti zakhumudwitsa ine sikunenena chilichonse. Dokotala wopezekayo adandipatsa zakudya zapadera, ndipo mankhwalawo "Berlition 300". Ngakhale kuti sindimwa mapiritsi nthawi yayitali, koma ndikumva bwino kwambiri, mutu wanga udayima kutuluka, magazi anga adatsika. Ndikukonzekera kumaliza maphunziro onse ndikuchepetsa kuchuluka kwa shuga m'magazi m'njira zovomerezeka. Mwa njira, mtengo umakhala pakati, pali mankhwala osokoneza bongo komanso okwera mtengo kwambiri, koma osati chifukwa chakuti azikhala othandiza ngati "Berlition 300"

Osati kale kwambiri pomwe ndidazindikira kuti ndili ndi matenda ashuga, kuti ndichepetse zizindikirazo ndikubwezeretsanso thupi bwino, adotolo adandiuza njira zosiyanasiyana. Ndinayamba kutsata shuga. Berlition adandichitira maphunziro ake. Chithandizo pamtengo wokwera. Lactose, yomwe ndi gawo la kapangidwe kake, ndimapirira mosavuta. Palibe zoyipa zomwe zapezeka. Koma matendawo atamwa mankhwalawa abwerera mwakale.

Berlition adaperekedwa kwa mwamuna wake kuti amuchiritse kuledzera komwe kumachitika ndi mowa. Mtengo si wocheperako, koma maphunzirowa ndi oyenera. Panalibe chilichonse chosangalatsa pophatikizana, mankhwalawa adagwira mwachangu. Patatha sabata limodzi, mwamuna wake adayamba kuchira ndipo adamva bwino. Popeza mankhwalawa amachepetsa shuga, timamwa mowonjezera kuti tikonzenso pambuyo pake.