Zatsopano pamankhwala a shuga 1

Berlin, Germany, Okutobala 2, 2018- Mu kafukufuku wa Step by Step, mutatha kugwiritsa ntchito masabata 26 a mankhwala a Ryzodeg ® insulin kamodzi patsiku kwa odwala omwe ali ndi matenda a shuga a 2, kuwongolera kofanana ndi glucose kumatheka pogwiritsa ntchito jakisoni wambiri komanso kutsitsa insulini yatsiku ndi tsiku chiopsezo chopanda masoka hypoglycemia poyerekeza ndi insulin glargine 100 IU kamodzi patsiku limodzi ndi insulin. Ryzodeg ® ndi kuphatikiza kwa insulin degludec ndi insulin aspart (IDegasp) mu cholembera chimodzi kuti athandizire odwala omwe ali ndi matenda a shuga a 2. Zotsatira za kafukufuku wa Step by Step zaperekedwa lero pamsonkhano wapachaka cha 54 wa European Association for the Study of Diabetes (EASD 2018) ku Berlin, Germany. 1

"Odwala angavutike kutsatira njira zovuta zochizira matenda omwe amafunika jakisoni ambiri nthawi zosiyanasiyana masana, zomwe zimapangitsa kuti magazi asayende bwino," atero Athena Philis-Tsimikas, wofufuza wotsogolera ku Step Wolemba a Step ndi wachiwiri kwa wachiwiri kwa Purezidenti wa Hypps Whittier Diabetes Institute. - Zotsatira za phunziroli zikuwonetsa kuti kugwiritsa ntchito IDegasp kamodzi patsiku kumatha kupatsa anthu odwala matenda a shuga a 2 mtundu wosavuta kwambiri wosankha kugwiritsa ntchito jakisoni ochepa kuti akwaniritse bwino magazi shuga poyerekeza ndi insulin glargine 100 mayunitsi limodzi ndi insulin ".

Pambuyo pa masabata 26, odwala omwe amalandira Rizodeg ® kamodzi pa tsiku insulin amagwiritsa ntchito jakisoni ochepera 50% ndikuchepetsa kwambiri kuchuluka kwa insulin tsiku lililonse (12%) poyerekeza ndi insulin glargine 100 PIECES kuphatikiza ndi insulin. 1

Pogwiritsa ntchito insulin Risedeg ® kamodzi patsiku latha masabata 26, pamakhala kuchepa kwapadera kwa ma epicode a nocturnal kwambiri kapena kutsimikizika kwa magazi glucose (GC) a hypoglycemia wa 45% poyerekeza ndi insulin glargine 100 IU kuphatikiza ndi insulin. Pafupipafupi ma episode omwe anali ovuta kapena otsimikizika a HK hypoglycemia anali ochepa poyerekeza ndi Ryzodeg ® kamodzi patsiku poyerekeza ndi insulin glargine 100 IU kuphatikiza ndi insulin. 1

“Zochitika za hypoglycemia, makamaka usiku, nthawi zambiri zimawopseza anthu omwe ali ndi matenda ashuga. Kugwiritsa ntchito inshuwaransi ya Rysodeg ® kamodzi patsiku sikuti kumangopereka yankho lophweka, komanso kumachepetsa kwambiri ngozi yakukula kwa usiku hypoglycemia poyerekeza ndi ndondomeko yoyambira ya basel, atero a Mads Krogsgaard Thomsen, Wachiwiri kwa Purezidenti ndi Chief Science Officer Wotsogolera kampaniyo Novo Nordisk. "Tikukhulupirira kuti jakisoni wocheperako tsiku lililonse wa Ryzodeg ® insulin athandizira kuchepetsa kuchuluka kwa matenda ashuga komanso kupangitsa kuti anthu odwala matenda ashuga atsatire malangizo omwe angawathandize."

Zambiri pa Ryzodeg ®

Ryzodeg ® ndi kuphatikiza kwa mitundu iwiri yosiyanasiyana ya insulini (insulin degludec ndi insulin aspart mu chiyerekezo cha 70% ndi 30%). Uku ndiko kuphatikiza koyamba kwa insulin insulin yayitali ndi insulini ya prandial cholembera kamodzi, yopangidwa kuti ichiritse odwala omwe ali ndi matenda a shuga a mtundu woyamba 1. 3-6 Ryzodeg ® ili ndi maubwino a mamolekyulu a insludec insulin. 7, 8 Mankhwala a Ryzodeg ® amathandizidwa ndi jekeseni wa subcutaneous kamodzi kapena kawiri pa tsiku asanakudye chakudya chachikulu. 4 Ryzodeg ® imapereka kuyambitsa kwa insal and prandial insulin mu cholembera chimodzi chimbudzi ndipo imapangitsa kuti chithandizo chisakhale chogwiritsa ntchito jakisoni ochepa kuposa basal ndi bolus insulin. 3

Ryzodeg ® idavomerezedwa koyamba ndi oyang'anira mu December 2012 ndipo idalandira chilolezo kuchokera ku European Medicines Agency mu Januware 2013. Kuchokera nthawi imeneyo, Ryzodeg ® adalembetsedwa m'maiko opitilira 90, kuphatikiza United States mu Seputembara 2015. Pakadali pano, akugulitsidwa m'maiko 20. Ku Russia, Ryzodeg® idavomerezedwa mu 2013.

Novo Nordisk Ndi kampani yapadziko lonse yopanga mankhwala yoposa zaka 95 zatsopano komanso utsogoleri pakusamalira matenda ashuga. Chifukwa cha nkhaniyi, tili ndi luso komanso luso lothandizira anthu kulimbana ndi kunenepa kwambiri, hemophilia, dysplasia ndi matenda ena akuluakulu. Kampaniyo Novo Nordisk, yochokera ku Denmark, ili ndi antchito pafupifupi 43,100 m'maiko 79, ndipo kampaniyo ikugulitsidwa kumayiko opitilira 170.

Zatsopano pa matenda a shuga: matekinoloje, njira, mankhwala

Pochizira mafupa, owerenga athu adagwiritsa ntchito DiabeNot bwino. Kuwona kutchuka kwa malonda, tidaganiza zoperekera chidwi chanu.

Chaka chilichonse, asayansi padziko lonse lapansi amachita kafukufuku wambiri ndi njira zatsopano zochizira matenda ashuga. Kugwiritsa ntchito mankhwalawa kumangowongolera kuwongolera kwa glucose komanso kupewa zovuta. Komabe, asayansi amapanga njira zatsopano zomwe zimathandizira kuchira.

• Chithandizo chatsopano cha matenda a shuga 1
• Chithandizo chatsopano cha matenda a shuga a 2
• Mankhwala Atsopano a shuga

Makhalidwe ndi kapangidwe ka insulin

Ryzodeg ndi insulin wa nthawi yayitali. Ndiwisi wopanda mafuta.

Inapezedwa ndi ma genetic engineering mwa kusintha molekyulu ya DNA ya anthu omwe amagwiritsa ntchito yisiti ya Saccharomyces cerevisiae.

M'mapangidwe ake ma insulin awiri adaphatikizidwa: Degludec - wokhala ndi nthawi yayitali komanso Aspart - wayifupi, muyezo wa 70/30 pa 100 mayunitsi.

Mu 1 unit ya insulin Ryzodeg muli 0,0256 mg Degludek ndi 0,105 mg Aspart. Cholembera chimodzi cha syringe (Raizodeg Flex Touch) chili ndi 3 ml ya yankho, motero magawo 300.

Kuphatikizika kwapadera kwamagulu awiri okhudzana ndi insulini kunapereka chidziwitso chabwino kwambiri cha hypoglycemic, posakhalitsa makonzedwe ndikupanga maola 24.

Makina a kuchitapo kanthu ndi kuphatikiza kwa mankhwala omwe amaperekedwa ndi odwala ndi insulin zolandilira. Chifukwa chake, mankhwalawa amakwaniritsidwa ndipo zotsatira zachilengedwe za hypoglycemic zimatheka.

Basal Degludec amapanga ma microcamera - ma deposti ena m'dera lochepa. Kuchoka pamenepo, insulin kwa nthawi yayitali imasunthira pansi ndipo osalepheretsa zotsatira zake ndipo sasokoneza kuyamwa kwaifupi Aspart insulin.

Insulin Rysodeg, mogwirizana ndi kuti amalimbikitsa kutsika kwa shuga m'magazi, imalepheretsa glycogen kutuluka kwa chiwindi.

Malangizo ogwiritsira ntchito

Mankhwala Ryzodeg amangoyambika mwa mafuta ochulukirapo. Sitha kubayidwa kudzera m'mitsempha kapena kudzera m'mitsempha.

Amakonda kuti jakisoni apangidwe m'mimba, ntchafu, nthawi zambiri m'mapewa. Ndikofunikira kusintha malo a jekeseni molingana ndi malamulo apakati oyambira algorithm.

Ngati jakisoni ikuchitika ndi Ryzodeg Flex Touch (cholembera), ndiye kuti muyenera kutsatira malamulowo:

Makatoni amagwiritsidwa ntchito kupangira “zolembera”. Zovomerezeka kwambiri ndi Ryzodeg Penfill.

Rysodeg Flex Kukhudza - cholembera chosinthanso. Onetsetsani kuti mwatenga singano zatsopano pa jakisoni aliyense.

Imapezeka pamalonda. Flexpen ndi syringe yotayika yolemba ndi penfill (cartridge).

Risodeg imalembedwa kwa odwala omwe ali ndi matenda amtundu wa 1 komanso a 2. Amasankhidwa kamodzi pa tsiku musanadye chakudya chachikulu. Nthawi yomweyo, insulin yochepa imayendetsedwa musanadye.

Syringe cholembera kanema pophunzitsa:

Mlingo amawerengedwa ndikuwonetsetsa kuchuluka kwa shuga m'magazi a wodwala. Amawerengeredwa aliyense payekha kwa wodwala aliyense ndi endocrinologist.

Pambuyo pa makonzedwe, insulin imatengedwa mwachangu - kuyambira mphindi 15 mpaka ola limodzi.

Mankhwala alibe contraindication matenda a impso ndi chiwindi.

Sitikulimbikitsidwa kugwiritsa ntchito:

• ana ochepera zaka 18
• pa mimba
• uku mukuyamwa
• ndi kuchuluka kwa chidwi cha munthu payekha.

Zofanizira zazikulu za Ryzodeg ndi ma insulini ena omwe akhala akuchita kwa nthawi yayitali. Mukasintha Ryzodeg ndi mankhwalawa, nthawi zambiri sasintha ngakhale mlingo.

Mwa izi, zotchuka kwambiri:

Mutha kuzifanizira mogwirizana ndi tebulo:

Ndikofunikira kuganizira malingaliro pa kayendetsedwe ka Tujeo: ndibwino komanso mosamala kuyang'ana ntchito ya cholembera SoloStar, popeza kulephera kungayambitse kuchuluka kwina kopanda vutoli. Komanso, kufuula kwake mwachangu kunakhala chifukwa cha kuwonekera kwa malingaliro angapo oyipa pamabungwe.

Chithandizo chatsopano cha matenda a shuga 1

Choyamba, ndikofunikira kukambirana za zomwe zachitika posachedwa komanso momwe zinthu zasinthira pochiza matenda amtundu woyamba 1:

1. Osati kale kwambiri, sensor yatsopano idawoneka yomwe imayeza glycemia pogwiritsa ntchito laser system. Idapangidwa ndi kampani yotchuka "Net Science". Chipangizocho chimakhazikitsidwa ndi chizindikiro cha fluorescent, chifukwa chomwe chimatha kudziwa kuchuluka kwa shuga mumphindi zochepa zokha. Palibenso chifukwa chobayira chala ndi kutolera magazi kuti aunike.
2. Ndi hypoglycemia, ndichizolowezi kugwiritsa ntchito "Glucagon" yamafuta, yomwe imasungunuka ndi yankho lapadera ndikupaka intramuscularly. Matekinolo amakono akonzanso mankhwalawa omwe amagwira ntchito mwachangu, kuti achepetse kugwiritsa ntchito.
   Izi ndizofunikira kwambiri kwa ana ndi achinyamata, chifukwa "Glucagon" yatsopanoyo ikhoza kugwiritsidwa ntchito kulikonse, ngakhale atakhala pa tebulo. Ili ndiye Glucagon Nasal Powder Nasal Spray, lomwe linapangidwa ndi Locemia Solutions. Horimoni Glucagon imayendetsedwa kudzera m'mphuno, pambuyo pake imalowa mu mucous nembanemba. Mtengo wa chipangizocho siwokwera kwambiri, choncho mankhwalawa amapezeka kwa anthu onse.
3. Medtronic yapanga insulin pampu yatsopano yokhala ndi zabwino zambiri pamitundu yapitayi. Awa ndi ma pump ochokera pa Medtronic Minimed Paradigm mndandanda. Pompo amatha kuyikika m'malo 8 osiyanasiyana, omwe amapereka chitonthozo chapadera kwa wodwala. Imakhala ndi kachitidwe koletsa kutsekeka kwa machubu ndi kudzikongoletsa ndi singano yodziyimira pawokha. Kuphatikiza apo, kuchuluka kwa shuga kumayang'aniridwa mphindi zisanu zilizonse. Pakusintha pang'ono, woipa adzamva chizindikiro. Ngati mugwiritsa ntchito pampu ya Veo, wodwalayo sadzafunika kuyendetsa kayendedwe ka insulin, monga momwe makina ake azichitira izi payekha.

Ntchito yokhala ndi tsinde

Maselo owuma mthupi la munthu amapangidwa kuti azikonza ziwalo zowonongeka ndikupanga matenda a carbohydrate metabolism. Mu shuga mellitus, kuchuluka kwa maselo otere kumatsika kwambiri, chifukwa chomwe zovuta zimayamba, ndikupanga insulin yachilengedwe. Kuphatikiza apo, chitetezo cha mthupi chimafooka. Chifukwa chake, ndikofunikira kwambiri kulipirira kuchuluka komwe kulibe maselo a tsinde. Asayansi a Harvard aphunzira kukula maselo olimbitsa thupi a ma cell B mu labotale, chifukwa chomwe insulin imapangidwa moyenera, minofu yowonongeka imabwezeretseka ndipo chitetezo chimalimba.

Kafukufuku wachitika pa mbewa zomwe zimayambitsa matenda ashuga. Chifukwa cha kuyesaku, makoswe adachiritsidwa kwathunthu ku matenda oopsawa. Pakadali pano, chithandizo choterechi chimagwiritsidwa ntchito ku Germany, Israel ndi United States of America. Chomwe chimapangidwira ndi kupangika kwa maselo a stem ndikuwayambitsanso thupi la odwala matenda ashuga. Maselo amalumikizana ndi minyewa ya kapamba, yomwe imayang'anira insulin, pambuyo pake timadzi timene timapanga. Chifukwa chake, mlingo ndi kukhazikitsidwa kwa mankhwala a insulin amachepetsa, ndipo mtsogolo nthawi zambiri amathetsedwa.

Kugwiritsa ntchito ma cell a tsinde kumakhala ndi zotsatira zabwino machitidwe onse amthupi. Izi ndizofunikira kwambiri ku zotupa mu impso, ziwalo zoberekera ndi ubongo.

Njira ya Thirani ya Fat Fat

Kafukufuku waposachedwa wa chithandizo chatsopano cha matenda ashuga ndikuwonjezera mafuta kwamafuta. Njirayi imachepetsa kufunika kwa insulini ndikuthandizira kagayidwe kazakudya. Izi ndichifukwa choti mamolekyulu a glucose adzatengedwa kwambiri ndi ma lipid maselo a mafuta a bulauni. Mafuta awa amapezeka mu nyama zochuluka kwambiri zomwe zimabisala, komanso makanda. Pazaka zambiri, mafuta amatsika m'magulu ambiri, motero ndikofunikira kuti abwezenso. Zofunikira zimaphatikizira kuchuluka kwa shuga m'magazi ndikuwonjezera njira ya metabolic.

Kuyesera koyamba pothira mafuta minofu ya bulauni kunachitika ku University of Vanderbilt mu mbewa. Zotsatira zake, zidapezeka kuti zoposa theka la zoyeserera zomwe adazipeza zidachotsa matenda ashuga. Pakadali pano, palibe amene adalandira chithandizo ichi.

Katemera wochizira matenda ashuga

Kupanga kwa insulin kumatengera momwe maselo a B alili. Pofuna kupewa kutupika ndi kuletsa kupititsa patsogolo kwa matendawa, ndikofunikira kusintha molekyu ya DNA. Wasayansi ya Stanford Steinman Lawrence adagwira ntchito imeneyi. Adapanga katemera wobwezeretsanso wotchedwa lawrence steinman. Imachepetsa chitetezo cha mthupi pamlingo wa DNA, chifukwa chake insulin yokwanira imapangidwa.

Chinsinsi cha katemera ndicholetsa yankho la chitetezo chamthupi. Chifukwa cha zoyesa zaka 2, zidawululidwa kuti ma cell omwe amawononga insulin adachepetsa ntchito yawo. Katemera, palibe zoyipa zomwe zimachitika ndi zovuta zomwe zidadziwika. Katemera sanapangidwire kupewa, koma chithandizo.

Njira yosinthira

Masiku ano, madokotala padziko lonse lapansi akupereka njira yosinthira, chifukwa chake ndizotheka kuchiritsa matenda a shuga 1. Mutha kuyika zinthu izi:

• kapamba, kwathunthu kapena pang'ono,
• maselo a beta
• zilumba za Langerhans,
• gawo la impso
• maselo a tsinde.

Ngakhale zikuwoneka bwino, njirayi ndiyowopsa, ndipo zotsatira zake sizotalika. Chifukwa chake, pambuyo pakuchita opaleshoni, pamakhala ngozi ya zovuta. Anthu odwala matenda ashuga pambuyo pakuchita opaleshoni amatha kuchita popanda insulini kokha kwa zaka 1-2.

Ngati wodwalayo atsimikiza kuchitidwa opaleshoni, ndikofunikira kutsatira zonse zomwe dokotala wamupatsa. Ndikofunikira kwambiri kuti dokotala azikhala ndi chidziwitso chambiri komanso chidziwitso chambiri, popeza chithandizo chosasankhidwa bwino cha postoperative (kotero kuti kulumikizana sikungachotse) kungayambitse zotsatira zoyipa.

Chithandizo chatsopano cha matenda a shuga a 2

Mtundu wachiwiri wa matenda ashuga osadalira insulin, anthu ambiri samayang'ana kwambiri matendawa. Komabe, izi ndizofunikira, popeza mtundu wachiwiri umayamba kukhala woyamba. Ndipo njira zakuchira zimasankhidwa mopitilira muyeso. Masiku ano, pali njira zatsopano zochizira matenda amitundu iwiri.

Kugwiritsa ntchito zida zamagetsi

Chida 1. Zipangizo zatsopano Magnetoturbotron zimaphatikizapo chithandizo kudzera pakukhudzidwa ndi maginito. Mankhwala osokoneza bongo sawachotsa. Amagwiritsidwa ntchito pa matenda a shuga a 2. Pogwiritsa ntchito chipangizochi, mutha kuchiritsa osati matenda a shuga okha, komanso kuthana ndi mavuto ena ambiri. Mwachitsanzo, kulimbitsa dongosolo lozungulira, lomwe ndilofunika kwambiri kwa matenda ashuga.

Mkati mwa kukhazikitsa, maginito amapangidwa, omwe amangotuluka nthawi zonse. Izi zimasinthasintha pafupipafupi, liwiro komanso kayendedwe kazungulira. Izi zimapangitsa kuti athe kusintha momwe amayendera kupita ku matenda enaake. Kuchita izi kumadalira pakupanga minda ya vortex mthupi, yomwe imalowa mkati mwa minofu yakuya kwambiri. Njirayi imatenga mphindi zosachepera 5 pasiti yoyamba. Nthawi yowonjezereka imawonjezeka ndimphindi zochepa. Ingodutsani magawo 15. Zotsatira zimatha kuchitika pakumwa komanso pambuyo pake kwa mwezi umodzi.

Chida chachiwiri. Kalelo mu 2009, kafukufuku adayamba pa njira yothetsera matenda a shuga. Mpaka pano, zoyesa zambiri zachitika zomwe zapereka zotsatira zabwino. Chifukwa chake, cryosauna imagwiritsidwa ntchito kale ngati mankhwala.

Njirayi imatengera kukhudzana ndi mpweya wa cryogenic wokhala ndi kutentha kochepa. Panthawi yonseyi, wodwalayo amaikidwa mu cryosauna yapadera, pomwe mpweya ndi nayitrogeni zimaperekedwa. Kutentha kumachepa pang'onopang'ono ndipo kumangokhala ndi mphindi ndi theka. Kutalika kwa njirayi ndi 3 maminiti okwanira.

Kuwonetsedwa kotere kuzizira kumayambitsa kuchepetsedwa ndi kukulitsa kwamitsempha yamagazi ndikuwonjezera kugwira ntchito kwa mathero amitsempha, ziwalo zamkati. Izi zimalimbikitsa kukonzanso kwamaselo ndikusinthanso kwa maselo owonongeka.

Pambuyo pa cryotherapy, maselo amthupi amazindikira insulin ngati munthu wathanzi. Izi zimatheka chifukwa chofulumira komanso kukonza njira zonse za metabolic - chakudya, mafuta, michere ndi zina zotero.

Chida chachitatu. Chithandizo cha laser tsopano chikugwiritsidwa ntchito pafupifupi konsekonse. Mankhwalawa amtundu wa matenda a shuga a mtundu wachiwiri, zida zama cellum zimagwiritsidwa ntchito, chifukwa chomwe laser imatumizidwa kumalo osokoneza bongo a kapamba.

Amagwiritsa ntchito ma radiation ya pulsed, infrared, maginito ndi kukoka ndi kuwala kofiira. Kutulutsa kumalowerera mkati mwa zigawo zazing'ono zam'mimba ndi maselo, ndikuwakakamiza kuti azigwira ntchito mwamphamvu. Zotsatira zake, kuchuluka kwa insulin kumachulukanso. Zotsatira zake, mankhwala ochepetsa shuga amachepetsa.

Monotherapy

Posachedwa, asayansi akukonda kwambiri malingaliro akuti kugwiritsa ntchito fiber mu shuga ndikofunikira. Makamaka ngati matendawa akuphatikizidwa ndi kunenepa kwambiri. Monotherapy nthawi zonse imasonyezedwa kwa kupatsa mphamvu kwa metabolism. Chifukwa chakuti mbewu cellulose imachepetsa kuchuluka kwa glucose omwe amalowetsa m'matumbo, shuga yamagazi imachepetsedwa. Feature - fiber iyenera kudyedwa pamodzi ndi zovuta zamafuta.

Pazithandizo zina zamatenda a 2 shuga, werengani apa.

Mankhwala atsopano a matenda a shuga 1

1. "Lantus SoloStar" amatanthauza insulin. Imakamizidwa pang'onopang'ono, zotsatira zake zimatha maola 24. Amapangidwa ndi kampani ya Sanofi-Aventis.
2. Humulin NPH ndi m'badwo watsopano wa insulin. Imalola kuwongolera kwakukulu kwa shuga.
3. "Humulin M3" imawonetsedwa ngati analogue yamankhwala am'mbuyomu, momwe amatha kwa maola 15.

Mankhwala atsopano a matenda a shuga a 2

1. DPP-4 inhibitor (dipeptidyl peptidase-4). Chosakaniza chachikulu chogwira ntchito ndi sitagliptin. Amatsitsa shuga m'magazi pokhapokha pamimba yopanda kanthu, ndiye kuti m'mimba muli ndi njala. Woimira wowoneka bwino ndi mankhwala "Januvia." Zotsatira zimatha tsiku. Amaloledwa kugwiritsa ntchito kunenepa kwambiri nthawi iliyonse. Chowonjezerapo ndikuchepetsa hemoglobin wa glycated ndipo mkhalidwe ndi magwiridwe antchito amaselo amapezeka bwino.
2. GLP-1 inhibitor (glucagon-polypeptide). Kuchita izi kumadalira pakupanga insulini, yomwe imachepetsa shuga ya magazi ndikuletsa kukula kwa glucagon, komwe kumalepheretsa insulini kuti isungunuke shuga. Chachilendo cha gululi ndikuti hypoglycemia siinayambike, popeza pambuyo pokhazikika pakukhazikika kwa magazi m'magazi, mankhwalawa amaleka kuchitapo kanthu (kuchepetsa kwambiri shuga). Itha kumwa mankhwala onenepa kwambiri komanso mankhwala ena. Zotsalira zake ndi jakisoni wa GLP-1 receptor agonists ndi insulin. Mwa mankhwala odziwika titha kuzindikira kuti "Galvus" ndi "Onglizu".
3. GLP-1 receptor agonists ndi mahomoni omwe amalembera maselo a kapamba kuti apange insulini. Kukonzekera kumapangitsanso maselo owonongeka a B ndikuchepetsa kumverera kwanjala, chifukwa chake amalimbikitsidwa kuti azinenepa kwambiri. Kuti mankhwalawa azikhala nthawi yayitali, ndikosayenera kudya chakudya kwa maola angapo, chifukwa chakudya chimawononga zinthu zomwe zimagwira. Mutha kuthana ndi agonists ndi mankhwala: "Baeta" ndi "Victoza."
4. Alfa glucosidase zoletsa. Chochitikacho chikufuna kupewa kutembenuka kwa chakudya kukhala shuga. Pachifukwa ichi, mankhwala amatengedwa mukatha kudya. Ndi zoletsedwa kugwiritsa ntchito limodzi ndi mankhwala "Metformin". Mankhwala odziwika bwino: Diastabol ndi Glucobay.

Anthu ambiri amakayikira njira zatsopano zoperekera matenda ashuga ndi mankhwala obwera kumene. Komabe, lingaliroli ndi lolakwika, chifukwa asayansi padziko lonse lapansi akuyesera kupeza njira yabwino komanso yothandiza kwambiri yothetsera matenda ashuga. Kuphatikiza apo, njira zonse ndi mankhwalawa zimayendetsedwa kubwezeretsa maselo a beta ndikupanga insulin yawo yomwe.

Insulin Risedeg - yankho latsopano kuchokera ku Novo Nordisk

Makampani ogulitsa mankhwala samayima - chaka chilichonse amapereka mankhwala ochulukirapo komanso ovomerezeka.

Insulin si yosiyana ndi izi - pali mitundu yatsopano ya mahomoni, omwe amapangidwira kuti moyo ukhale wosavuta kwa odwala matenda a shuga, omwe chaka chilichonse amakhala ochulukirachulukira.

Chimodzi mwazomwe zachitika masiku ano ndi insulin Raizodeg kuchokera ku kampani Novo Nordisk (Denmark).

Mtengo wa mankhwala

Ndikulimbikitsidwa kuti ambiri omwe amapatsidwa insulin pochiza matenda a shuga 1 ndi a Ryzodegum.

Mtundu wa 2 odwala matenda ashuga omwe ali ndi mlingo wa inshuwaransi ya Ryzodeg ayenera kuperekedwa tsiku lililonse.

Pali ndemanga zambiri zabwino zokhudzana ndi kugwiritsa ntchito mankhwalawa - ndizotchuka kwambiri, ngakhale kuti kugula mankhwala mumafakitare sikophweka.

Mtengo udzatengera mtundu wa kumasulidwa.

Mtengo wa Ryzodeg Penfill - katiriji kapu yama 300-unit 3 ml iliyonse imachokera ku 6594, 8150 mpaka 9050 ngakhalenso ruble 13000.

Raizodeg FlexTouch - cholembera cha syringe 100 IU / ml mu 3 ml, Ayi. 5 phukusi, mutha kugula kuchokera ku 7070 mpaka 8737 rubles.

Ndikofunikira kukumbukira kuti m'malo osiyanasiyana komanso mitengo yazamankhwala payokha idzasiyana.

Kodi ndi mapiritsi ati othandiza odwala matenda ashuga?

Matenda a shuga ndi osachiritsika, koma masiku ano mankhwala ali ndi mitundu ingapo ya mankhwala omwe angathe kuthana ndi matendawa. Mapiritsi a shuga amathandizira pochita zinthu zina, kuchepetsa mavuto obwera chifukwa cha kuperewera kwa thupi m'thupi. Kuchiza matendawa kumatheka bwino ngati mankhwala omwe dokotala amakupatsani akaphatikizidwa ndi zakudya zapadera zotsatiridwa ndi wodwalayo. Chimodzi mwazinthu zokhazikika pamtundu wa odwala matenda ashuga ndi zochitika zolimbitsa thupi, ayenera kukhala okwanira ku msinkhu ndi thanzi la wodwalayo.

Pazolinga ndi zolinga

Cholinga chachikulu cha chithandizo cha matenda ashuga ndi kusintha kuchuluka kwa shuga m'thupi. Kuti muthane ndi vutoli, ndikofunikira kuyang'anitsitsa shuga wamagazi ndikuchitapo kanthu kuti muchepetse kuchuluka kwake. Ngati sizotheka ndi thandizo lamankhwala kuti mupeze kuchuluka kwa shuga, munthu amamwalira. Kuti mugwiritse ntchito bwino matenda a shuga mellitus pamafunika zovuta mankhwala. Zimaphatikizapo osati kumwa mapiritsi okha, komanso:

• kuletsa zakudya zamafuta ambiri
• matenda oyamba a zovuta za matenda.

Chithandizo cha matenda amtundu 1 komanso matenda amtundu wa 2 ali ndi tanthauzo lake. Wodwala akapezeka ndi matenda amtundu 1, amafunika jakisoni wofunika kwambiri. Thupi laumunthu silingathenso kudzipangira payokha insulin yofunikira kuti ichite bwino.

Mndandanda wamankhwala omwe amaperekedwa kwa mtundu uwu wa matenda a shuga umaphatikizapo mankhwala odziwika bwino a Tatyanin.

Kusankha kwamankhwala kwa wodwala kuli ndi ufulu wochita dokotala wokha. Muyenera kudziwa: mankhwalawa nthawi zambiri amakhala ndi dzina lomweli, koma amasiyana wina ndi mnzake mu liwiro lochita komanso kuchuluka kwa insulin. Chizindikiro choyamba ndichofunikira kwambiri pakuwunika momwe mankhwalawo alili. Mapiritsi a shuga ndi jakisoni akhoza kukhala mtundu umodzi wokha wa insulin. Zopanda insulin zomwe zimaphatikizidwamo nthawi zambiri zimagwiritsidwa ntchito mosakaniza. Poganizira mtundu wa insulini ndi zinthu zomwe zili pokonzekera, njira yochiritsira wodwala imapangidwira. Njira yosiyanitsira yopangira mapiritsi a shuga ndi jakisoni imakupatsani mwayi wokulitsa mphamvu ya njira zomwe zimatengedwa motsutsana ndi matendawa.

Kodi mankhwala amafunikira?

Kodi anthu omwe akupezeka ndi matenda a shuga a 2 amafunikira mankhwala? Ili ndi funso lovuta. Komabe, odwala oterewa sangamwe mankhwala kwa nthawi yayitali. Matenda a mtundu wachiwiri amakula pang'onopang'ono kuposa oyambayo. M'magawo oyamba a matenda a shuga 2, mankhwalawa nthawi zambiri safunikira. Udindo wawo umachitika ndi zakudya komanso maphunziro olimbitsa thupi, omwe amakhala ndi vuto la shuga mthupi. Kumbali ina, akulephera kuletsa matendawa, chifukwa chake, pamlingo wina, kugwiritsa ntchito mapiritsi a shuga kuyenera. Zomwe zimayikidwa poika mankhwala zitha kukhala kuchepa mphamvu kwa zolimbitsa thupi ndi zakudya.

Pakulimbana kwathunthu komanso matendawa

Pali magulu atatu a mankhwalawa omwe amagwiritsidwa ntchito pa matenda ashuga, gulu lawo limatengera momwe amakhudzira thupi. Gulu loyamba limaphatikizapo njira zomwe zimalimbikitsa kugwira ntchito kwa kapamba. Gulu lachiwiri ndi mankhwala omwe amalimbikitsa chidwi cha minofu ya mthupi kumayambitsa ma metabolic a insulin. Gulu lachitatu limachepetsa kuyamwa kwa shuga ndi m'mimba. Gawo lomalizali limaphatikizaponso mankhwala omwe amathandizira kuthira kwa mafuta a shuga m'thupi. Gulu lililonse muli mitundu yosiyanasiyana ya mankhwala omwe amakulitsa katundu umodzi. Mwachitsanzo, mphamvu ya mankhwalawa mu shuga ingathe kulimbikitsa ntchito ya kapamba ndi kutulutsa kwa insulin. Ndalama zomwe zimapangitsa kuti thupi lizisamaliridwa bwino, nthawi zambiri zimaperekedwa kwa anthu omwe ali ndi matenda a shuga 2, kapena kwa iwo omwe ali onenepa kwambiri, ngati njira yoteteza.

Mankhwala omwe amachititsa chidwi cha minofu kuti insulin ichepetse kuphatikizira kwa shuga kwa chiwindi. Pogwiritsa ntchito, kuphatikiza chithandizo ndi monotherapy zimachitika bwino.

Mankhwala omwe amachepetsa mayamwidwe a shuga m'mimba ndi mawu atsopano pa mankhwalawa a matenda a shuga ndi matenda omwe amayambitsidwa ndi matenda a metabolic. Koma ngati munthu ali ndi matenda am'mimba kapena impso, ndiye kuti mankhwalawa saikidwa. Kugawidwa kwa mankhwalawa m'magulu atatu kumayesedwa kwofunikira, chifukwa mankhwala ambiri ali ndi zizolozo zomwe zimawalola kupatsidwa magulu angapo nthawi imodzi.

Chifukwa chiyani ma antioxidants amafunikira?

Mankhwala amakono amasiyanitsa mankhwala a antioxidant omwe amagwiritsidwa ntchito pochiza matenda osokoneza bongo omwe ali m'gulu lapadera.

Vuto la metabolic, lomwe limakhala ndi matenda, limapangitsa kuwonjezeka kwa chiwongolero chaulere m'thupi. Kodi izi zimawopseza bwanji munthu? Ma radicals aulere amawononga ma cell a ziwalo zamkati ndikupanga kusintha kosasinthika kapangidwe ka kapamba. Zosasinthika pakugwira ntchito kwake zimakulitsidwa ndipo kupitirira kwa shuga kumathandizira. Kugwiritsa ntchito antioxidants kungalepheretse njirazi ndikuletsa kupezeka kwa zovuta zambiri zokhudzana ndi matenda a shuga.

Posankha mankhwala omwe mankhwalawo adzagwiritsidwa, dokotala ayenera kukumbukira:

• kuchuluka kwa shuga komwe kumachepetsa thupi,
• mphamvu ya chitetezo chamthupi.

Njira yabwino ndiyo kugwiritsa ntchito mankhwala omwe ali ndi zinthu zonse ziwiri. Kugwiritsa ntchito mwadongosolo mankhwalawa kumathandizanso kukhala ndi thanzi la odwala matenda ashuga komanso kumalepheretsa zovuta ku matenda ashuga. Zogwiritsidwa ntchito kwambiri pochiza matenda a Maninil, Diabetes, Glyurenorm, Amaril, Glucobay, Insulat ndi ena mankhwala. Pamodzi ndi mapiritsi, makampani opanga mankhwala amagwira ntchito popanga zakudya zamagulu osiyanasiyana, zomwe zimagwiritsidwa ntchito ngati zothandiza pakukonza shuga.

Mimba komanso kuyamwa

Kugwiritsidwa ntchito kwa Ryzodeg® Penfill® pa nthawi ya pakati kumatsutsana, chifukwa palibe chidziwitso chachipatala chogwiritsira ntchito pakubala. Kafukufuku wokhudzana ndi kubereka kwa nyama sikuwululira kusiyana pakati pa insludec insulin ndi insulin ya anthu malinga ndi embryotoxicity ndi teratogenicity.

Nthawi yoyamwitsa

Kugwiritsa ntchito kwa mankhwala a Ryzodeg® Penfill® pa nthawi yoyamwitsa kumatsutsana, chifukwa palibe chidziwitso chachipatala chogwiritsa ntchito kupaka mkaka azimayi.

Kafukufuku wazinyama adawonetsa kuti mu makoswe, degludec insulin imachotsedwa mkaka wa m'mawere, ndipo kuchuluka kwa mankhwala mkaka wa m'mawere kumatsika kuposa plasma yamagazi. Sizikudziwika ngati insulin degludec imachotsedwa mkaka wa amayi.

Kafukufuku wazinyama sanapeze zovuta za Refludec insulin pa chonde.

Kugwiritsidwa ntchito kwa mankhwala a Ryzodeg® FlexTouch ® pa nthawi ya pakati kumapangidwa, chifukwa palibe chidziwitso chachipatala chogwiritsira ntchito pakubala. Kafukufuku wokhudzana ndi kubereka kwa nyama sikuwululira kusiyana pakati pa insludec insulin ndi insulin ya anthu malinga ndi embryotoxicity ndi teratogenicity.

Kugwiritsa ntchito mankhwala a Ryzodeg® FlexTouch ® pakumwa kuyamwa kumatsutsana, chifukwa palibe chidziwitso chachipatala chogwiritsa ntchito kupaka mkaka azimayi.

Mimba

Kugwiritsa ntchito kwa mankhwala Ryzodeg FlexTouch pa nthawi ya pakati kumayesedwa, chifukwa palibe zovuta zamankhwala zomwe zimagwiritsidwa ntchito panthawi yomwe ali ndi pakati.Kafukufuku wokhudzana ndi kubereka kwa nyama sikuwululira kusiyana pakati pa insludec insulin ndi insulin ya anthu malinga ndi embryotoxicity ndi teratogenicity.

Kuyanjana kwa mankhwala osokoneza bongo

Pali mankhwala angapo omwe amakhudza kufunika kwa insulin. Kufunika kwa insulin kumatha kuchepetsedwa: mankhwala a hypoglycemic mankhwala, glucagon-peptide-1 receptor agonists (GLP-1), Mao inhibitors, osagwiritsa ntchito beta-blockers, ACE inhibitors, salicylates, anabolic steroids ndi sulfonamides.

Kufunika kwa insulin kumatha kuchuluka: Kulera kwapakati kwa mahomoni, thiazide diuretics, glucocorticosteroids, mahomoni a chithokomiro, sympathomimetics, somatropin ndi daiazole. Beta-blockers amatha kufinya zizindikiro za hypoglycemia. Octreotide / lanreotide imatha kuwonjezeka ndikuchepetsa kufunikira kwa insulin.

Ethanol imatha kukulitsa ndikuchepetsa mphamvu ya insulin.

Mankhwala ena, atawonjezeredwa ku Ryzodeg® Penfill®, amatha kuyambitsa kuwonongeka kwa Refludec insulin ndi / kapena insulin aspart. Rizodeg® Penfill® sayenera kuwonjezeredwa pazankho. Osasakaniza mankhwalawa ndi mankhwala ena.

Pali mankhwala angapo omwe amakhudza kufunika kwa insulin.

Kufunika kwa insulin kumatha kuchepetsedwa: mankhwala a hypoglycemic mankhwala, glucagon-peptide-1 receptor agonists (GLP-1), Mao inhibitors, osagwiritsa ntchito beta-blockers, ACE inhibitors, salicylates, anabolic steroids ndi sulfonamides.

Kufunika kwa insulin kumatha kuchuluka: Kulera kwapakati kwa mahomoni, thiazide diuretics, glucocorticosteroids, mahomoni a chithokomiro, sympathomimetics, somatropin ndi danazole.

Beta-blockers amatha kufinya zizindikiro za hypoglycemia.

Octreotide / lanreotide imatha kuwonjezeka ndikuchepetsa kufunikira kwa insulin.

Mankhwala ena, akaphatikizidwa ndi kukonzekera kwa Ryzodeg® FlexTouch ®, angayambitse kuwonongeka kwa Refludec insulin ndi / kapena insulin. Ryzodeg® FlexTouch® sayenera kuwonjezeredwa pazankho. Osasakaniza mankhwalawa ndi mankhwala ena.

subcutaneous yankho

Ryzodeg - malangizo ogwiritsira ntchito, mtengo, ndemanga ndi fanizo

Mankhwala Ryzodeg amangoyambika mwa mafuta ochulukirapo. Sitha kubayidwa kudzera m'mitsempha kapena kudzera m'mitsempha.

Amakonda kuti jakisoni apangidwe m'mimba, ntchafu, nthawi zambiri m'mapewa. Ndikofunikira kusintha malo a jekeseni molingana ndi malamulo apakati oyambira algorithm.

Ngati jakisoni ikuchitika ndi Ryzodeg Flex Touch (cholembera), ndiye kuti muyenera kutsatira malamulowo:

1. Onetsetsani kuti ziwalo zonse zili m'malo omwe 3 ml cartridge ali ndi 300 IU / ml ya mankhwalawa.
2. Onani ngati singano zotayika NovoFayn kapena NovoTvist (kutalika 8 mm).
3. Mukachotsa chipewa, yang'anani yankho. Ziyenera kukhala zowonekera.
4. Khazikitsani mlingo wofunikira pa cholembera ndikusintha chosankha.
5. Kukanikiza pa "kuyamba", gwiritsitsani mpaka dontho la yankho litatuluke kumapeto kwa singano.
6. Pambuyo pa jekeseni, wogwirizira wa mankhwalawo amayenera kukhala 0. Chotsani ndi singano pambuyo masekondi 10.

Makatoni amagwiritsidwa ntchito kupangira “zolembera”. Zovomerezeka kwambiri ndi Ryzodeg Penfill.

Rysodeg Flex Kukhudza - cholembera chosinthanso. Onetsetsani kuti mwatenga singano zatsopano pa jakisoni aliyense.

Imapezeka pamalonda. Flexpen ndi syringe yotayika yolemba ndi penfill (cartridge).

Risodeg imalembedwa kwa odwala omwe ali ndi matenda amtundu wa 1 komanso a 2. Amasankhidwa kamodzi pa tsiku musanadye chakudya chachikulu. Nthawi yomweyo, insulin yochepa imayendetsedwa musanadye.

Mlingo amawerengedwa ndikuwonetsetsa kuchuluka kwa shuga m'magazi a wodwala. Amawerengeredwa aliyense payekha kwa wodwala aliyense ndi endocrinologist.

Pambuyo pa makonzedwe, insulin imatengedwa mwachangu - kuyambira mphindi 15 mpaka ola limodzi.

Mankhwala alibe contraindication matenda a impso ndi chiwindi.

Sitikulimbikitsidwa kugwiritsa ntchito:

• ana ochepera zaka 18
• pa mimba
• uku mukuyamwa
• ndi kuchuluka kwa chidwi cha munthu payekha.

Chithandizo chogwira ntchito: chisakanizo cha insulin degludec ndi insulin aspart pa 70/30 (ofanana ndi 2.56 mg wa insulini Refludec ndi 1,05 mg wa insulin aspart) 100 PESCES

Omwe amathandizira: glycerol - 19 mg, phenol - 1.5 mg, metacresol - 1.72 mg, zinc 27.4 μg (monga zinc acetate 92 μg), sodium chloride 0.58 mg, hydrochloric acid kapena sodium hydroxide (pakusintha kwa pH), madzi d / ndi. - mpaka 1 ml.

• kuchuluka kwa chidwi cha munthu pazinthu zothandizira kapena chilichonse chothandiza cha mankhwalawo.
• ana ochepera zaka 18,
• Nthawi yokhala ndi pakati komanso yoyamwitsa (palibe zovuta zamankhwala zokhudzana ndi kugwiritsa ntchito mankhwalawa kwa ana, amayi panthawi yoyembekezera komanso yoyamwitsa)

Malangizo ogwiritsira ntchito

Ryzodeg Penfill ndi kuphatikiza kwa mankhwala osungunuka a insulle - super-eside basal insulin (degludec insulin) komanso wothamanga wa prandial insulin (insulin aspart).

Mankhwala chikuyendetsedwera 1 kapena 2 pa tsiku musanadye waukulu. Ngati ndi kotheka, odwala ali ndi mwayi wosintha mosagwiritsa ntchito mankhwala, koma amayenera kumangirizidwa ku chakudya chachikulu.

Odwala omwe ali ndi vuto la matenda a shuga 2, Ryzodeg Penfill angagwiritsidwe ntchito ngati monotherapy, kaphatikizidwe ndi PHGP kapena bolus insulin.

Odwala omwe ali ndi vuto la matenda a shuga 1 amawerengedwa monga Risodeg Penfill osakanikirana ndi insulin yochepa / yofupikitsika yochepa asanadye nawo.

Mlingo wa Ryzodeg Penfill umatsimikiziridwa payekha malinga ndi zosowa za wodwala. Kuti muwongolere kuyendetsa bwino glycemic, ndikofunikira kukonza ma mpesa a mankhwalawa pamaziko a kusala kwa glucose ofunika.

Monga momwe amakonzera insulin iliyonse, kusintha kwa mankhwalawa kungafunike ngati zochitika zolimbitsa thupi zamukulira, chakudya chake chikasintha, kapena nthenda yina.

Mlingo woyambirira wa Ryzodeg Penfill

Odwala a shuga a 2

Mlingo woyenera wa tsiku lililonse wa Ryzodeg penfill ndi magawo khumi, kenako nkusankhidwa ndi munthu piritsi.

Odwala Awa Matenda A shuga Aakulu

Mlingo woyambira wa Ryzodeg Penfill ndi 60-70% ya zonse zofunika tsiku lililonse.

Mankhwala a Ryzodeg Penfill amaperekedwa kamodzi patsiku chakudya chachikulu limodzi ndi insulin yofulumira / yochepa, yoyendetsedwa musanadye zakudya zina, kenaka ndikusankhidwa kwa munthu.

Chotsani kuchokera kukonzekera kwina kwa insulin

Kusanthula mosamala kwa shuga wamagazi pakasamu ndikusunthidwa koyambirira kwa mankhwala atsopano ndikofunikira. Pangakhale kofunikira kukonza chithandizo cha gnogoglnkemicheskoy (mlingo ndi nthawi ya makonzedwe a insulin pokonzekera kochepa komanso ultrashort kapena piritsi la PHGP).

Mukasamutsa odwala omwe amalandila insulin kapena biphasic insulin Therapy kamodzi patsiku kuti akhale ulesi, mlingo wa Ryzodeg Penfill uyenera kuwerengedwa pazoyambira pang'onopang'ono kuchokera ku mlingo wonse wa insulin womwe wodwalayo adalandira asanasamuke ku mtundu watsopano wa insulin.

Posamutsa odwala omwe ali ndi njira yopitilira muyeso umodzi wa basal kapena biphasic insulin, muyezo wa Ryzodeg Penfill uyenera kuwerengedwa pang'onopang'ono, ndikusamutsira kawiri kwa Ryzodeg! wodwala adalandira asanasamalidwe ku mtundu watsopano wa insulin.

Mukasamutsa odwala pamaziko a ipusulipotherapy ya bolus. Mlingo wa Ryzodeg® Penfill® uyenera kuwerengera potengera zosowa za wodwalayo. Monga lamulo, odwala amayamba ndi kumwa womwewo wa basal insulin.

Mlingo woyambirira wa Ryzodeg® Penfill® ndi 60-70% ya insulini yofunika tsiku lililonse kuphatikiza ndi insulini yochepa / yochepa-yochepa yochita ndi zakudya zina ndikusankhidwa kwa mtundu wa mankhwalawo.

Malamulo osinthika a dosing

Nthawi yoyendetsa Ryzodeg Penfill imatha kusintha ngati nthawi yayikulu ya chakudya isinthidwa.

Ngati mankhwalawa a Ryzodeg Penfill asowa, wodwala amatha kulowa tsiku lotsatira ndi chakudya chotsatira, ndikubwerera kunthawi yake ya mankhwala. Mlingo wowonjezera suyenera kuperekedwa kuti ulipirire mlingo womwe wakuphayo.

Magulu apadera a odwala

Ryzodeg Penfill angagwiritsidwe ntchito mwa odwala okalamba. Kuphatikizika kwa shuga wamagazi kuyenera kuyang'aniridwa mosamala komanso mlingo wa insulin payokha ikusintha (onani gawo la Pharmacokietics).

Ryzodeg penfill angagwiritsidwe ntchito mwa odwala mkhutu aimpso ndi kwa chiwindi ntchito. Kuphatikizika kwa shuga m'magazi kuyenera kuyang'aniridwa mosamala ndi mlingo wa insulin womwe umasinthidwa payekhapayekha (onani Pharmacokietics sub sub).

Zambiri zomwe zapezeka mu pharmacokinetic zimawonetsedwa m'gawo la Pharmacokinetics, komabe, magwiridwe antchito ndi chitetezo cha mankhwala a Ryzodeg Penfill mwa ana ndi achinyamata osakwana zaka 18 sizinaphunziridwe, ndipo malingaliro pa kumwa kwa mankhwalawa mu ana sanapangidwe.

Mankhwala a Ryzodeg Penfill amangogwira wokhazikitsidwa ndi mankhwalawa. Mankhwala a Ryzodeg Penfill sangathe kutumikiridwa kudzera m'mitsempha, chifukwa izi zimatha kuyambitsa kukula kwa hypoglycemia. Mankhwala a Ryzodeg Penfill sangathe kutumikiridwa intramuscularly, popeza pamenepa kupezeka kwa mankhwalawa kumasintha. Ryzodeg penfill sayenera kugwiritsidwa ntchito pamapampu a insulin.

Ryzodeg Penfill imathandizidwa mosanyamula kwa ntchafu, khoma lakunja lam'mimba, kapena phewa. Masamba a jakisoni amayenera kusinthidwa pafupipafupi m'dera lomwelo kuti muchepetse chiopsezo cha lipodystrophy. Makatoni a Penfill adapangidwa kuti agwiritsidwe ntchito ndi jekeseni ya Novo Nordisk insulin ndi singano za NovoFailili NovoTvist.

Mimba

Kugwiritsa ntchito mankhwala a Ryzodeg Penfill pa nthawi ya pakati kumatsutsana, chifukwa palibe zovuta zamankhwala zomwe zimagwiritsidwa ntchito panthawi yomwe ali ndi pakati. Kafukufuku wokhudzana ndi kubereka kwa nyama sikuwululira kusiyana pakati pa insludec insulin ndi insulin ya anthu malinga ndi embryotoxicity ndi teratogenicity.

Kugwiritsa ntchito mankhwala a Ryzodeg Penfill panthawi yoyamwitsa kumatsutsana, chifukwa palibe chidziwitso chazachipatala chogwiritsidwa ntchito popaka akazi.

Mankhwala Ryzodeg Penfill ndi chophatikiza chophatikizika chosakanizira cha insulin yaumunthu ya superlong kanthu (insulin degludec) komanso yolimbikira yolumikizana mwachangu ya insulin (insulin aspart), yopangidwa ndi recombinant DNA biotechnology yogwiritsa ntchito Saccharomyces cerevisiae.

Insulin degludec ndi insulin aspart mwanjira inayake yomangiriza ku cholandirira cha amkati a insulin komanso kuyanjana nacho, zindikirani zochitika zam'magazi zofanana ndi zovuta za insulin ya anthu. Hypoglycemic zotsatira za insulin imayamba chifukwa cha kugwiritsidwa ntchito kwa glucose pambuyo pomanga insulin ku minofu ndi ma cell cell receptors, komanso kutsika kwamtundu womwewo kwa kuchuluka kwa shuga ndi chiwindi.

Mankhwala

Zotsatira za pharmacodynamic zamagulu a mankhwala a Ryzodeg penfill ndizosiyana kwambiri ndipo mbiri yonse ya mankhwalawa imawonetsa mbiri ya zomwe zimachitika munthu payekha: insulin aspart yayikulu komanso insulin degludec yapamwamba kwambiri.

Gawo loyambira la mankhwala a Ryzodeg Penfill, lomwe limakhala ndi nthawi yayitali (insulin degludec), pambuyo pobayira jekeseni wosakanikirana mu malo obisalirako, kuchokera komwe kumalowetsedwa pang'onopang'ono insulin degludec ndikazungulira, ndikuwonetsa pang'onopang'ono zochitika zamankhwala komanso chokhazikika cha hypoglycemic. Izi zimasungidwa limodzi ndi insulini ndipo sizikhudza kuchuluka kwa mayamwidwe olimbikira a insulin.

Ryzodeg Penfill amayamba kuchitapo kanthu mwachangu, ndikupereka chofunikira cha insulin posachedwa, pomwe gawo loyambira lili ndi mawonekedwe osasunthika komanso osasinthika omwe amapereka chofunikira cha insulin insulin. Kutalika kwa gawo limodzi la Ryzodeg Penfill ndi maola oposa 24.

• Mankhwala a Ryzodeg flex touch novonordisk amayimira gulu la ma insulin omwe amafanana ndi munthu ndipo amagwiritsidwa ntchito ngati endocrine akusokonezeka kwa kapangidwe ka pancreatic mwa akulu.
• Kapangidwe ka Ryzodega Flex kamakhala ndi ma insulin awiri: basal degludec wokhala ndi nthawi yayitali komanso phula, chinthu chosakhalitsa
• Momwe mungatenge Ryzodeg iyenera kuyikidwa kokha ndi katswiri wazachipatala wodziwa bwino.
• Kugwiritsa ntchito Ryzodeg pa nthawi ya pakati, panthawi yogwira lactofform, hypersensitivity kwa zigawo zina za mankhwala, siziloledwa.
• Ana osakwana zaka 18 saloledwa kupereka rizodeg

- kuchuluka kwa chidwi cha munthu pazinthu zothandizira kapena chilichonse chothandizira cha mankhwala,

- ana osaposa zaka 18,

- nthawi ya pakati komanso yoyamwitsa (palibe chovuta ndi mankhwalawa kwa ana, amayi panthawi yoyembekezera komanso yoyamwitsa),

- nthawi ya pakati komanso yoyamwitsa (palibe chidziwitso chazachipatala chokhudzana ndi kugwiritsa ntchito mankhwalawa kwa ana, amayi panthawi yoyembekezera komanso yoyamwitsa).

Matenda a shuga mwa akulu.

Kuchulukitsa chidwi cha munthu payekha pazinthu zothandizira kapena chilichonse chothandizira cha mankhwalawo.

Ana osakwana zaka 18 zakubadwa, nthawi ya pakati komanso yoyamwitsa (palibe chidziwitso chachipatala ndi mankhwalawa mu ana, azimayi panthawi yoyembekezera komanso yoyamwitsa).

Malangizo ogwiritsira ntchito cholembera cha Tresiba Flextach

Tresiba Flextach ndi mankhwala ochepetsa shuga. Ndi analogue ya anthu omwe akhala akuchita insulin. Chifukwa cha mawonekedwe ake a zamankhwala, Tresiba nthawi zambiri amagwiritsidwa ntchito ndi odwala omwe ali ndi matenda a shuga omwe amadalira matenda a shuga. Imagwiritsidwa ntchito ngati maziko osungitsa kuchuluka kwa insulin m'magazi.

Zomwe zimapangitsa kuti kudalira insulini kumakhala kosiyanasiyana. Mtundu woyamba wa matenda a shuga a mellitus, omwe ndi achinyamata, amathandizidwa ndi insulin kale. Popeza kapamba sangathe kutulutsa timadzi tomwe timalowa m'magazi chifukwa cha zovuta zina zamtundu.

Matenda a 2 a shuga, omwe amapezeka pakatikati pa anthu, amapezeka motsutsana ndi maziko amasinthidwe am'magazi a ma pancreatic cell ndi chitukuko cha kukana kwa cell receptors ku insulin. Matenda a shuga ngati amenewa safunikira chithandizo mwachangu pokonzekera insulin. Pokhapokha ndi nthawi yomwe kusakwanira kwa zisumbu za Langerhans ndikumasulidwa kwa mahomoni kumayamba, motero.

Tresiba Flextach ili ndi mawonekedwe apadera omwe amathandizira kwambiri moyo wa odwala matenda ashuga. Mankhwalawa amapezeka mu cholembera, omwe amachititsa kuti ma insulin akhale osavuta komanso osapweteka komanso amawongolera njira zochitira mankhwalawo.

Treshiba imagulitsidwa mu phukusi la zolembera 5. Mtengo wapakatikati wozungulira umachokera ku 7600 - 8840 rubles.Izi ndizopindulitsa kwambiri, chifukwa mtengo umasonyezedwanso nthawi yomweyo kwa zolembera 5.

Mawonekedwe ndi mawonekedwe a mankhwalawa

Mankhwala Tresiba Flextach amapezeka mu cholembera cholembera chololeza chophatikizika. Mankhwalawa amapezeka mu 2 Mlingo, womwe ndi wofunikira kwambiri kwa odwala omwe ali ndi kulemera kwakukulu komanso njira yovuta ya matenda ashuga. Makilogalamu atatu aliwonse. Chifukwa chake, zolembera 300 ndi 600 za insulin zilipo.

Mu 1 ml yankho la jakisoni muli chinthu chachikulu cha insulin degludec 100 ndi 200 mayunitsi.

Zofanana ndi izi:

• Glycerol - 19.6 / 19.6 mg,
• Metacresol - 1.72 / 1.72 mg,
• Phenol - 1.5 / 1.5 mg,
• Hydrochloric acid,
• Zinc - 32.7 / 71.9 mcg,
• Sodium hydroxide,
• Madzi a jakisoni - mpaka 1/1 ml.

Mankhwala akhoza kutumikiridwa muyezo wa 80/160 U / kg. Pankhaniyi, gawo la kusintha kwa mlingo ndi gawo limodzi kapena awiri. Gawo lililonse la insulin ya insludec limafanana ndi gawo limodzi la insulin yaumunthu.

Njira yamachitidwe

Limagwirira a zochita za mankhwala zachokera wathunthu agonism wa insulin degludec ndi amkati anthu. Ikamamwa, imamangilira ma insulin receptors mu minofu, makamaka minofu ndi mafuta. Chifukwa cha zomwe, njira ya mayamwidwe a shuga m'magazi imayatsidwa. Palinso kuchepa kwa Reflex pakupanga kwa glucose ndi ma cell a chiwindi kuchokera ku glycogen.

Recombinant insulin degludec imapangidwa pogwiritsa ntchito ma genetic engineering, omwe amathandizira kupatula DNA ya mabakiteriya a Saccharomyces cerevisiae. Mtundu wawo wama genetic ndi wofanana kwambiri ndi insulin yaumunthu, yomwe imathandizira kwambiri komanso imathandizira kupanga mankhwala. Nkhumba ya nkhumba imagwiritsidwa ntchito kale. Koma adayambitsa machitidwe ambiri ochokera mthupi.

Kutalika kwake kwa thupi ndi kukonzanso kwa insulin okwanira maola 24 kumalimbikitsidwa ndi machitidwe ake omwe amachokera ku mafuta osaneneka.

Mothandizidwa ndi subcutaneally, insulin degludec imapanga malo owerengeka omwe amasungunuka ambiri. Mamolekyu amamanga maselo amafuta, omwe amachititsa kuti mankhwalawo amvedwe pang'onopang'ono m'magazi. Komanso, njirayi ili ndi gawo lathyathyathya. Izi zikutanthauza kuti insulin imakomoka chimodzimodzi kwa maola 24 ndipo sikunasinthe.

Zizindikiro ndi contraindication

Chizindikiro chokhacho komanso chokhacho chogwiritsira ntchito insulin yayitali ndi mtundu 1 kapena mtundu 2 wa shuga. Degludec insulin imagwiritsidwa ntchito kusunga kuchuluka kwa mahomoni m'magazi kuti matenda akhale ndi metabolism.

Milandu yayikulu ndi:

1. Kusalolera payekhapayekha pazigawo za mankhwala,
2. Mimba komanso nthawi yobereka;
3. Ana osakwana chaka chimodzi.

Zotsatira zoyipa

Pa chithandizo, zimachitika zovuta. Chotsatira chovuta kwambiri ndi hypoglycemia. Amawonedwa, monga lamulo, mwa odwala omwe amapitilira mlingo womwe unawonetsedwa, amatsatira molondola malangizowo, kapena kuti dokosi linasankhidwa molakwika.

Hypoglycemia imawonetsedwa ndi zizindikiro zosiyanasiyana, zomwe pamlingo wina wake zimadalira kuperewera kwa ubongo ndi shuga m'magazi. Udindo wofunikira umachitidwanso ndi mulingo wamba wa shuga momwe thupi la wodwalayo limazolowera.

Kuwonetsedwa kwa mziwi kumachitika kawirikawiri. Mbali iyi nthawi zambiri imadziwika ndi zochita za anaphylactic zamtundu wapomwe, zomwe zimachitika chifukwa cha tsankho la munthu pamagulu ena a mankhwalawo.

Nthawi zambiri anaphylaxis amawonetsedwa mu mawonekedwe a:

• Urticaria
• Kuyabwa
• Edincke's edema,
• Erythema,
• Kugwedezeka kwa anaphylactic.

Zochita zakomweko pakukonzekera mankhwala nthawi zambiri zimawonedwa. Wodwalayo amadandaula za kutupa kwanuko, kuyabwa, malo okundana ndi jakisoni. Mchitidwe wofooka komanso kuwawa kwawoko ndi kakhalidwe.

Zochitika za lipodystrophy nthawi zambiri zimawonedwa pamene malangizo ogwiritsira ntchito satsatidwa. Mukamatsatira malamulowo ndikusintha jakisoni nthawi iliyonse, mwayi wokhala ndi lipodystrophy udzachepa.

Bongo

Chizindikiro chodziwika bwino cha mankhwala osokoneza bongo ndi hypoglycemia. Izi zimachitika chifukwa cha kuchepa kwa glucose m'magazi motsutsana ndi maziko a insulin. Hypoglycemia imatha kudziwonetsa ndi zizindikiro zosiyanasiyana, zomwe zimatengera kuopsa kwa vutolo.

Hypoglycemia ikhoza kukayikiridwa ngati zingapo mwa zotsatirazi zikuwoneka:

• Chizungulire
• W ludzu
• Njala
• Pakamwa pakamwa
• Thukuta lozizira
• Zingwe
• Kuyabwa
• Kutentha
• Zotsatira
• Kumva nkhawa
• Kulankhula zopanda pake ndi masomphenya,
• Kuzindikira koperewera mpaka kufa.

Thandizo loyamba la hypoglycemia wofatsa lingaperekedwe ndi achibale kapena wodwala. Kuti matenda asinthe, muyenera kubweretsanso kuchuluka kwa shuga m'magazi.

Ngati vutoli lili lalikulu kwambiri ndikuyambitsa kuphwanya chikumbumtima, muyenera kuyimbira ambulansi nthawi yomweyo. Ndi kwambiri hypoglycemia, ndikofunika kukhazikitsa mankhwala a insulin - glucagon mu mlingo wa 0,5-1 mg intramuscularly kapena subcutaneally. Ngati glucagon kulibe pazifukwa zina, akhoza m'malo mwa ena odana ndi insulin. Mahomoni a chithokomiro, glucocorticoids, catecholamines, makamaka adrenaline, somatotropin angagwiritsidwe ntchito.

Mankhwala ena amakhala ndi kukokoloka kwa jekeseni wa shuga ndikuwonetsetsa popanga shuga. Komanso onjezerani ma elekitirodi ndi kuchuluka kwa madzi.

Migwirizano ndi magwiritsidwe akusungidwa

Sungani cholembera cha ana kuti chisafike kwa ana. Kutentha kosungirako kosungirako kosatseka makatiriji osavomerezeka ndi +2 - +8 madigiri. Amaloledwa kuti azisungira mufiriji pachitseko cha khomo, lomwe limakhala kutali ndi mufiriji. Osamawumitsa mankhwalawo!

Pewani kuwonetsedwa ndi dzuwa komanso kutentha kwambiri. Kuti muchite izi, sungani makatoni otsekedwa mu zojambulazo zapadera, zomwe zimalumikizidwa ngati chitetezo.

Sungani cholembera chotseguka pofunda m'chipinda chodetsa. Kutentha kwambiri sikuyenera kupitirira +30 degrees. Kuti muteteze poizungulira, tsegulani cartridge ndi chipewa nthawi zonse.

Moyo wapamwamba kwambiri wa alumali ndi miyezi 30. Tsiku lotha litasonyezedwa phukusi, kugwiritsa ntchito mankhwalawa kumatsutsana. Makatoni otseguka okhala ndi cholembera amatha kugwiritsa ntchito kwa milungu 8.

Tresiba insulin ndi njira yabwino kwambiri yopangira syringe, yomwe imapangitsa moyo kukhala wosavuta pazinthu zambiri za insulin.

Pharmacokinetics

Pambuyo pakubaya kwapansipansi, ma Refludec angapo osakhazikika amapangidwa. Chifukwa cha izi, gawo lochekera lazinthu limapangidwa, ndikupereka kulowetsa pang'onopang'ono komanso kukhazikika m'magazi.

Aspart imalowa mwachangu: mbiriyo imapezeka pakatha mphindi 15 jekeseni pansi pakhungu.

Kuchotsa hafu ya moyo sikudalira kuchuluka kwa mankhwalawo ndipo pafupifupi 25 maola.

Amagwiritsidwa ntchito pochiza anthu omwe ali ndi matenda a shuga a mtundu woyamba 1.

Contraindication

Otsimikizika muzochitika zotere:

• Hypersensitivity kwa zigawo zogwirizira,
• manja
• yoyamwitsa
• wazaka 18.

Mankhwalawa amaperekedwa kamodzi kapena kawiri pa tsiku musanadye. Nthawi zina wodwala matenda ashuga amaloledwa kudziwa nthawi yoyendetsa yankho. Kwa anthu omwe ali ndi matenda a shuga a 2, mankhwalawa amaperekedwa ngati gawo la monotherapy, komanso kuphatikiza mankhwala a hypoglycemic omwe amagwiritsidwa ntchito mkati.

Kukulitsa kuchuluka kwa shuga m'magazi, kusintha kwamankhwala kumawonetsedwa pakuwonjezera masewera olimbitsa thupi, kusintha kwa zakudya.

Amayambitsidwa ntchafu, pamimba, molumikizana. Wodwalayo ayenera kusintha malo a jekeseni wa subcutaneous wa mankhwala.

Kutenga nthawi yayitali bwanji?

Kutalika kwa kuvomerezedwa ndi adokotala.

Katirijiyo adapangira kuti azigwiritsidwa ntchito ndi singano mpaka 8 mm kutalika. Cholembera ndi chongogwiritsa ntchito nokha. Dongosolo lake:

1. Onetsetsani kuti bokosi lamatumba lili ndi insulini ndipo silowonongeka.
2. Chotsani kapu ndikuyika singano yotayika.
3. Ikani mlingo pa zilembo pogwiritsa ntchito chosankhira.
4. Press Press Start kuti dontho laling'ono la insulini lithe kumapeto.
5. Pangani jakisoni. Chotsalira pambuyo pake chizikhala zero.
6. Tulutsani singano pakapita masekondi 10.

Nthawi zambiri hypoglycemia. Amayamba chifukwa cha mankhwala osankhidwa bwino, kusintha kadyedwe.

Nthawi zina jekeseni subcutaneous kumabweretsa kukula kwa lipodystrophy. Zitha kupewedwa ngati musintha jakisoni nthawi zonse. Nthawi zina hematoma, kukha magazi, kupweteka, kutupa, kutupa, kufiyanso, kuyimitsa khungu kumaonekera pakhungu. Amadutsa mwachangu popanda chithandizo.

Ming'oma ikhoza kuchitika.

Hypoglycemia imachitika ngati mlingo wa insulin ndi wapamwamba kuposa momwe amafunikira. Kutsika kwakuthwa kwa glucose kumayambitsa kusazindikira, kukokana komanso kusokonezeka kwa ubongo. Zizindikiro za mkhalidwewu zimakula mwachangu: thukuta lowonjezera, kufooka, kusachedwa, kukwiya, kutopa, kugona, njala, kutsekula m'mimba. Nthawi zambiri, kugunda kwamtima kumakulirakulira, ndipo masinthidwe amakhala operewera.

Kutupa kwa lilime, milomo, kulemera m'mimba, khungu loyenda, kutsegula m'mimba. Izi zimachitika kwakanthawi ndipo, popitilira chithandizo, zimatha pang'onopang'ono.

Chifukwa cha hypoglycemia, chidwi cha anthu amatha kudwala. Chifukwa chake, pangozi yochepetsera shuga, ndikulimbikitsidwa kuti musayendetse magalimoto kapena magalimoto.

Chifukwa chake, pangozi yochepetsera shuga, ndikulimbikitsidwa kuti musayendetse magalimoto kapena magalimoto.

Malangizo apadera

Mankhwala am'mbuyomu amatha kuyamba. Popita nthawi, amadutsa. Matenda opatsirana amawonjezera kuchuluka kwa insulin.

Mlingo wosakwanira wa Ryzodegum umabweretsa chitukuko cha zizindikiro za hyperglycemia. Zizindikiro zake zimawonekera pang'onopang'ono.

Kuchepa kwa adrenal gland, chithokomiro komanso chithokomiro cha pituitary chimafuna kusintha kwa mankhwala.

Ngati jakisoni wotsatira wasowa, ndiye kuti munthu akhoza kulowa muyezo womwewo patsiku lomwelo. Osamapereka mankhwalawa kawiri, makamaka mu mtsempha, chifukwa zimayambitsa hypoglycemia.

Sizoletsedwa kulowa intramuscularly, chifukwa mayendedwe a insulin amasintha. Osagwiritsa ntchito insulin iyi pampu ya insulin.

Munthawi yayitali yolumikizira, kusintha kwa magazi kumafunika.

Mukakalamba ndi matenda a concomitant pathologies, kusintha kwa mankhwalawa kumafunikira.

Kupatsa ana ntchito

Zokhudza ana sizinaphunzire. Chifukwa chake, akatswiri a matenda ashuga samalimbikitsa kupereka insulin iyi kwa ana osakwana zaka 18.

Sichiloledwa kwa azimayi panthawi yoyembekezera ndi poyamwitsa. Izi ndichifukwa chosowa maphunziro azachipatala okhudzana ndi chitetezo cha mankhwalawa nthawi izi.

Woopsa matenda a impso, kusintha kwa mlingo kumafunika.

Zitha kufuna kuchepa kwa kuchuluka kwa ndalama.

Ndi kuchuluka Mlingo, hypoglycemia imachitika. Mlingo weniweni womwe ungachitike sichoncho.

Fomu yofatsa imachotsedwa palokha: ndikokwanira kugwiritsa ntchito pang'ono lokoma. Odwala amalangizidwa kuti azikhala ndi shuga nawo. Ngati munthu sakudziwa, amamuika glucagon m'matumbo kapena pansi pa khungu. I / O amachitika kokha ndi wogwira ntchito yazaumoyo. Glucagon imayambitsidwa munthu asanatulutsidwe osazindikira.

Phatikizani insulin yofunika ndi:

• mankhwala amkamwa kuthana ndi hyperglycemia,
• agonists a GPP-1,
• Mao ndi ACE zoletsa,
• beta-blockers,
• kukonzekera kwa salicylic acid
• anabolic steroids
• sulfonamide othandizira.

Mukamayanjana ndi anabolics, insulin amafuna imachepa.

• Chabwino
• mankhwala kuti muwonjezere mkodzo,
• corticosteroids
• chithokomiro cha chithokomiro,
• Kukula kwamafuta,
• Danazole

Sizoletsedwa kuwonjezera mankhwalawa panjira yothetsera kulowetsedwa kwa mtsempha.

Ethanol imawonjezera mphamvu ya hypoglycemic.

Kuphatikizika ndi katundu

Ryzodeg ndi m'badwo watsopano wa basal insulin womwe ungagwiritsidwe ntchito bwino pochiza matenda a shuga a mtundu woyamba wa 2. Kupadera kwa Rysodegum kuli poti nthawi imodzi imakhala ndi insuludart yodziwikiratu komanso yochepa kwambiri ya insuludec.

Ma insulini onse omwe amagwiritsidwa ntchito popanga kukonzekera kwa Ryzodeg ndi fanizo la insulin yaumunthu. Amapezeka ndi makina obwereza omwe amagwiritsa ntchito DNA pogwiritsa ntchito yisiti ya genus Saccharomyces cerevisiae.

Chifukwa cha izi, amamangirira mosavuta ku cholandilira cha insulin yawo yaumunthu ndipo, pakulumikizana ndi izi, amalimbikitsa kuyamwa kwa shuga. Chifukwa chake, Ryzodegum imagwira ntchito monga ambulensi amkati.

Ryzodeg imakhudzanso kawiri: kumbali imodzi, imathandiza ziwalo zamkati mwathupi kuti zithetse bwino shuga kuchokera m'magazi, ndipo inayo, imachepetsa kwambiri kupanga kwa glycogen kudzera m'maselo a chiwindi. Izi zimapangitsa Ryzodeg kukhala imodzi mwa insulin yofunika kwambiri.

Chifukwa chake, Ryzodeg ali ndi kutchulidwa kwa hypoglycemic, ngakhale kuphatikiza kwa degludec ndi aspart. Izi ziwiri zomwe zimawoneka kuti ndizosagwirizana ndi insulin mu mankhwalawa zimapangitsa kuphatikiza kwakukulu komwe insulin siyimalimbana ndi kuyamwa kwakanthawi.

Kuchita kwa aspart kumayamba pokhapokha jakisoni wa Ryzodegum. Amalowetsedwa m'magazi a wodwalayo ndipo amathandizira kutsitsa shuga m'magazi.

Kupitilira apo, degludec imayamba kukhudza thupi la wodwalayo, lomwe limakamizidwa pang'onopang'ono ndipo limakwaniritsa kwathunthu kufunika kwa wodwala insulin ya maola 24.

Rysodeg iyenera kuthandizidwa pokhapokha ngati minyewa yolumikizira, popanda apo wodwalayo atha kukhala ndi zovuta zowopsa zomwe zimafuna chisamaliro chamankhwala mwachangu.

Kubayidwa ndi Ryzodegum ndikofunikira 1 kapena 2 pa tsiku musanadye kadzutsa, chakudya chamadzulo kapena nkhomaliro. Ngati angafune, wodwalayo amatha kusintha jakisoniyo nthawi yodziyimira, koma ngati mankhwalawo amalowa mthupi asanadye chakudya chachikulu.

Pochiza odwala omwe apezeka ndi mtundu wachiwiri wa matenda a shuga, Ryzodeg angagwiritsidwe ntchito ngati othandizira komanso kuphatikiza mapiritsi ochepetsa shuga kapena osapumira.

Mlingo wa mankhwala a Ryzodeg amayenera kusankhidwa mosiyanasiyana, poganizira momwe wodwalayo alili komanso zosowa zake. Kudziwa mlingo woyenera wa insulin ingakuthandizeni kwambiri kuyeza kuchuluka kwa shuga m'magazi. Ngati ichulukitsidwa, ndiye kuti mlingo wake umafunikira kukonzedwa mwachangu.

Kuphatikiza apo, kusintha kungafunike pakusintha kudya kwa wodwala kapena zolimbitsa thupi. Komanso, kudya mankhwala enaake kumakhudzanso shuga ya magazi, yomwe ingafune kuwonjezeka kwa Rysodeg.

Momwe mungasankhire mlingo wa basal insulin Ryzodeg:

1. Mtundu woyamba wa shuga. Ndi matendawa, mlingo wa Ryzodeg uyenera kukhala pafupifupi 65% ya zomwe wodwala amafunikira tsiku lililonse. Ndikofunikira kuperekera mankhwalawa kamodzi patsiku musanadye osakaniza ndi insulin yochepa. Ngati ndi kotheka, mlingo wa basal insulin uyenera kusintha,
2. Type 2 shuga. Kwa odwala omwe ali ndi mtundu uwu wa matendawa, ngati gawo loyambirira la mankhwalawa, tikulimbikitsidwa kulowa magawo 10 a Ryzodeg tsiku lililonse. Mlingowu amathanso kusinthidwa malinga ndi zosowa za wodwala payekha.

Momwe mungagwiritsire ntchito Ryzodeg:

• Ralg ya basal insulin imapangidwira ma subcutaneous makonzedwe. Mankhwalawa sioyenera kubayira jekeseni wam'mimba chifukwa amatha kuyambitsa matenda a hypoglycemia,
• Mankhwala Ryzodeg sangathenso kutumikiridwa mwachidwi, chifukwa pamenepa kuyamwa kwa insulini m'mwazi kumathandizira kwambiri.
• Ryzodeg sanapangidwe kuti adzagwiritse ntchito pampu ya insulin,
• Jekeseni wa insulin Ryzodeg uyenera kuchitidwa matako kapena m'mimba, nthawi zina amaloledwa kuyika jakisoni m'manja,
• Pakapita jakisoni aliyense, tsamba la jekeseni liyenera kusinthidwa kuti lipodystrophy isapezeke ndi matenda a shuga.

Mankhwala Ryzodeg angagwiritsidwe ntchito pochiza odwala mu gulu lapadera, omwe ali ndi zaka zopitilira 65 kapena akuvutika ndi vuto la impso kapena chiwindi. Komabe, pankhaniyi, muyenera kuyang'anira kuchuluka kwa shuga m'magazi ndipo ngati kuli koyenera, musinthe kuchuluka kwa insulin.

Insulin yoyambira iyi ingagwiritsidwe ntchito mankhwalawa matenda a shuga kwa ana ndi achinyamata osakwana zaka 18.

Koma palibe kafukufuku yemwe watsimikizira chitetezo cha Ryzodegum kwa odwala a ana.

Mtengo wa basal insulin Ryzodeg zimatengera mtundu wa mankhwalawa. Chifukwa chake makatoni amtundu wa 3 ml (300 PIECES) akhoza kugula pamtengo wa 8150 mpaka 9050 rubles. Komabe, m'mafakitala ena, mankhwalawa amaperekedwa pamtengo wokwera kwambiri, ma ruble 13,000.

Mtengo wa cholembera ndi syringe ndi wokhazikika ndipo, monga lamulo, umachokera ku 6150 mpaka 6400 rubles. Nthawi zina, amatha kufikira ma ruble 7000.

Nthawi zambiri, iwo amene akufuna kugula Ryzodeg amayenera kuyika mankhwala asanamwe mankhwala, chifukwa ngakhale mtengo wake umakhala wokwera, amagulitsidwa mwachangu ndi odwala omwe ali ndi matenda ashuga. Izi ndichifukwa choti ndemanga zakugwiritsa ntchito mankhwalawa zili zabwino kwambiri.

Insulin Rysodeg: ndemanga ndi zotsatira za mankhwalawa mu shuga

Basal, kapena monga amatchedwanso, ma insulins oyambira kumbuyo amatenga gawo lofunikira pothandizira matenda a shuga. Amathandizira kuti magazi azikhala ndi shuga pakati pa chakudya, amathandizanso kudziwa glycogen amene amasungidwa ndi ma cell a chiwindi.

Mpaka pano, ma insulins amakono adapangidwa, nthawi yomwe imatha kupitilira maola 42.

Imodzi mwa mankhwalawa ndi Ryzodeg, yemwe wakhala akupanga insulin nthawi yayitali.