Chofunikira chachikulu cha mankhwalawa ndi antioxidant amkati.

Thioctic acid amachepetsa kuchuluka kwa shuga m'magazi, amathandizira kuthana insulin kukana, komanso kumawonjezera zomwe zili glycogen mu chiwindi. Zili chimodzimodzi zachilengedwe za mavitamini a gulu B. Zimatenga gawo la lipid ndi carbohydrate metabolism, zimapangitsa ntchito ya chiwindi, imayendetsa metabolism cholesterol.

Kuphatikiza apo, thioctic acid imakhala ngati hepatoprotective, hypocholesterolemic, lipid-kutsitsa ndi hypoglycemic amatanthauza. Amakhala bwino mitsemphaamachepetsa kuwonekera kwa mowa ndi matenda ashuga polyneuropathyyambitsa mayendedwe a axonal.

Tsimikizirani kukonzekera kwa yankho ndi makina amkati kumachitika ndende 25-25 μg / ml. Kuchuluka kwa magawidwe ndi pafupifupi 450 ml / kg.

Makapiritsi ndi mapiritsi mukamamwa pakamwa amamwa nthawi yochepa. Ngati idya ndi chakudya, mayamwidwe amachepetsa. Bioavailability ndi 30-60%. Kuzindikira kwakukulu m'magazi kumafika m'mphindi 25-60.

Mosasamala mtundu wa kuchuluka kwa mankhwalawa, mankhwalawa amakonzedwa mu chiwindi ndi conjugation ndi oxidation yam'mbali. Imafufutidwa kudzera mu impso ndi 80-90%. Kutha kwa theka-moyo ndi mphindi 20-50.

Zisonyezo za Oktolipen

Zisonyezo za Oktolipen mu mawonekedwe a makapisozi a 300 ndi 600 mg:

• polyneuropathy a matenda ashuga,
• polyneuropathy zakumwa zoledzeretsa.

Zisonyezo za Oktolipen mu mawonekedwe a njira yothetsera kulowetsedwa kwa 12 ndi 25 mg:

Zotsatira zoyipa

Mukamagwiritsa ntchito mankhwalawa, zotsatirazi zingachitike:

• mawonekedwe a thupi lawo siligwirizana (ngakhale kugwedezeka kwa anaphylactic ndikotheka)
• kuchokera kugaya chakudya kumatheka nseru, kutentha kwa mtima, kusanza,
• Zizindikiro hypoglycemia.

Oktolipen - malangizo ogwiritsira ntchito

Kwa iwo omwe adalembedwa makapisozi kapena mapiritsi a Octolipen, malangizo omwe angagwiritsidwe ntchito amaphatikizapo kumwa tsiku lililonse m'mimba yopanda theka la ola musanadye. Kugwiritsa ntchito nthawi yomweyo kumachepetsa mphamvu ya mankhwalawa. Kutafuna ndi kutaya mapiritsi ndi makapisozi sikokwanira.

Mlingo wa tsiku ndi tsiku, womwe umapereka malangizo ogwiritsira ntchito Oktolipen - 600 mg (piritsi 1 kapena 2 makapisozi). Komabe, nthawi ya maphunziridwe ake ndi kuchuluka kwake kwa mankhwala ndi dokotala.

Kuonjezera mphamvu ya mankhwalawa nthawi zina, masabata awiri oyamba ndi 2 amakhala kuti akuyenera kugwiritsidwa ntchito pakukonzekera infusions, pambuyo pake mapiritsi kapena mapiritsi amagwiritsidwa ntchito muyezo waukulu.

Kukonzekera yankho, ma ampoules a 1-2 amagwiritsidwa ntchito, omwe amadziwitsidwa mu 50-250 ml ya 0.9% sodium chloride solution. Pambuyo pokonzekera, imayendetsedwa kudzera m'mitsempha. Mlingo wokhazikika ndi 300-600 mg patsiku.

Mankhwala amakhudzidwa ndi kuwala, kotero ma ampoules ayenera kuchotsedwa pokhapokha asanagwiritse ntchito. Pakadali pano, ndikofunikanso kuteteza vial ku dzuwa. Njira yothetserayo iyenera kusungidwa m'malo otetezedwa ku kuwala komanso osapitirira maola 6 mutakonzekera.

Kuchita

Mankhwala amadzuka Hypoglycemic zotsatira mankhwala a insulin komanso antidiabetes omwe amamwa pakamwa. Ndiye chifukwa chake, pophatikiza mankhwalawa, muyenera kuyang'anira kuchuluka kwa shuga wa m'magazi komanso kusintha momwe mankhwalawo amathandizira ngati alipo.

Kuphatikiza apo, muyenera kuyang'ana nthawi yayitali pakati pa kutenga Oktolipen ndi mkaka, komanso kukonzekera ndi chitsulo, calcium ndi magnesium. Pankhaniyi, ndikofunikira kutenga Oktolipen m'mawa, ndipo ndalama ndi chitsulo, magnesium ndi calcium m'mawa. Kuphatikiza apo, mankhwalawa amachepetsa mphamvu. chisplatin ndi munthawi yomweyo.

Kuchita bwino kwa Oktolipen palokha kumachepetsa mowa wa ethyl. Chifukwa chake mankhwalawa, tikulimbikitsidwa kuti musamwe mowa.

Thioctic acid imathandizanso anti-yotupa katundu glucocorticosteroid mankhwala.

Ndemanga za Oktolipen

Ndemanga za Oktolipen nthawi zambiri zimakhala zabwino. Odwala ambiri amawona kugwira kwake ntchito kotheka. Nthawi zina zimaperekedwa m'mafakisi kuti ndalama zodula Mgwirizano. Ndemanga za Oktolipen nthawi yomweyo akuti zotsatira za mankhwalawa ndizothandiza monga analogue yake.

Mapangidwe piritsi limodzi

Yogwira pophika, thioctic acid (ct-lipoic acid) - 600.0 mg. Othandizira:

pakati: Hyprolose yotsitsa (yotsika-hydroxypropyl cellulose) -108.880 mg, hyprolose (hydroxypropyl cellulose) 28.040 mg. croscarmellose (croscarmellose sodium) - 24.030 mg, colloidal silicon dioxide - 20,025 mg, magnesium stearate - 20.025 mg,

chipolopolo: Opadry chikasu (OPADRY 03F220017 Yellow) - 28,000 mg wa hypromellose (hydroxypropyl methylcellulose) - 15.800 mg, macrogol-6000 (polyethylene glycol 6000) -4.701 mg, titanium dioxide - 5.270 mg, talc - 2.019 mg, quinoline yellow aluminium. - 0,162 mg, utoto wazitsulo utayidi wachikasu (E 172) - 0,048 mg.

mapiritsi okutidwa ndi filimu film kuyika kuchokera ku chikaso chowoneka chikasu, chowonda, biconvex ndi chiopsezo mbali imodzi. Pakukala kuchokera pachikaso chowoneka chikaso.

Mankhwala

Thioctic (a-lipoic acid) acid imapezeka m'thupi la munthu, pomwe imakhala ngati coenzyme mu phosphorylation wa oxidative wa pyruvic acid ndi alpha-keto acid. Thioctic acid ndi endo native antioxidant. Thioctic acid imathandizira kuteteza maselo ku poizoni wamavuto aulere omwe amapezeka munjira za metabolic, amalepheretsa mankhwala ena oopsa. Thioctic acid kumawonjezera ndende ya amkati antioxidant glutathione, zomwe zimabweretsa kuchepa kukula kwa zizindikiro za polyneuropathy. Mankhwala ali ndi hepatoprotective. hypolipidemic, hypocholesterolemic, hypoglycemic effect, imakonza ma neurons a trophic. Machitidwe a synergistic a thioctic acid ndi insulin amachititsa kuti shuga agwiritsidwe ntchito kwambiri. Pharmacokinetics

Mukamamwa pakamwa, imathiridwa mwachangu komanso kwathunthu kuchokera m'mimba, kuthira pamodzi ndi chakudya kungachepetse kuyamwa kwa mankhwalawa. Kumwa mankhwalawa, malinga ndi malingaliro, mphindi 30 chakudya chisanafike kumakupatsani mwayi wopewa kuyanjana kosafunikira ndi chakudya, chifukwa kuyamwa kwa thioctic acid panthawi yakudya kumatha. Kuchuluka kwa thioctic acid m'madzi a m'magazi kumafika patatha mphindi 30 mutatha kumwa mankhwalawa ndipo ndi 4 μg / ml. Thioctic acid imakhala ndi "gawo loyamba" kudzera mu chiwindi. Mtheradi bioavailability wa thioctic acid ndi 20%. Njira zazikulu za metabolic ndi makutidwe ndi okosijeni ndi kulumikizana. Thioctic acid ndi ma metabolites ake amuchotsa impso (80-90%). Hafu ya moyo (T1 / 2) ndi mphindi 25.

Gwiritsani ntchito pa nthawi yoyembekezera komanso nthawi yoyamwitsa

Kugwiritsa ntchito mankhwalawa pa nthawi ya pakati kumapangidwa pakakhala kuti palibe mokwanira pazachipatala za thioctic acid pa nthawi yapakati. Kafukufuku wokhudza zoopsa za kubereka sanazindikire zoopsa pokhudzana ndi chonde, zomwe zimakhudza chitukuko cha fetal komanso mphamvu iliyonse ya mimbayo.

Kugwiritsa ntchito mankhwala Oktolipen pa yoyamwitsa zimaphatikizidwa pakalibe deta pa malowedwe a thioctic acid mkaka wa m'mawere.

Mlingo ndi makonzedwe

Mlingo woyenera ndi piritsi limodzi (600 mg) kamodzi patsiku. Mankhwalawa amagwiritsidwa ntchito pakamwa, pamimba yopanda kanthu, mphindi 30 asanadye kadzutsa, osatafuna, osambitsidwa ndi madzi.

Mu milandu ya munthu aliyense (yoopsa), mankhwalawa amayamba ndi kukhazikitsidwa kwa mankhwala a Okolipen mu mtsempha wa masabata 2-4, kenako ndikupatsidwa mankhwalawa ndi pakamwa mawonekedwe a mankhwala Okolipen® (mankhwala opatsirana pang'onopang'ono). Mtundu ndi nthawi ya maphunzirowa atsimikiza ndi dokotala.

Kuphatikizika, kusungirako ndi kugulitsa

Imapezeka mu umodzi mwa mitundu itatu yotheka: piritsi, kapisozi kapena kuchuluka kokulirapo kogwirizira kofunikira pakukonzekera mayankho a otsikira.

Monga zigawo zothandizira zimagwiritsidwa ntchito: pamapiritsi - calcium hydroorthophosphate (oyera kapena oyera makristali), magnesium stearate (ufa wosagawanika bwino wa imvi) ndi titanium oxide - utoto woyera. Mu makapisozi, mumagwiritsidwa ntchito zinthu zingapo zomwe zimapereka mawonekedwe amadzimadzi - gelatin, kuyimitsidwa kwa colloidal kwa silicon oxide, komanso miyala iwiri yachikaso: quinoline chikasu ndi "kulowa kwa dzuwa" (E 104 ndi 110, motero). Ma Ampoules omwe amakhala ndi chidwi amathandizidwa kwathunthu ndi zosungunulira kuchokera kumadzi osakanikirana ndi mchere wamchere wa EDTA.

Zochita zamankhwala

Ili ndi mndandanda wazotsatira zabwino mthupi. Pakati pawo:

• Neuroprotective - kuteteza maselo amitsempha, kuphatikiza maselo aubongo, pazotsatira zoyipa za matenda ena ndi poizoni. Imalola kuti muchepetse zovuta zoyipa za poizoni wa neurotoxin. Kuchulukitsa kwa axonal conductivity ndi trophic neurons.
• Hypoglycemic - kuchepa kwa shuga m'magazi onse. Imatha kuthandiza odwala omwe ali ndi matenda ashuga omwe ali ndi zovuta kuchiritsa ngati polyneuropathy. Gwiritsani ntchito mosamala anthu mukangomwa insulin kapena kwa anthu omwe ali ndi zochulukirapo za pancreatic.
• Hypocholesterolemic - imayambitsa kuchepa kwa mafuta m'thupi, motero mankhwalawa amatengedwa chifukwa cha kulephera kwa chiwindi, kuchepa kwamafuta ndi chiwindi china.
• Hepatoprotective - mankhwalawa amachepetsa kapena kuthetsa zotsatira za chiwindi, zomwe zimapangitsa kuti asinthe komanso kufa kwa cell. Amatengedwa ngati mbali yovuta yothandizira matenda a chiwindi, amachepetsa mayendedwe a matendawa ndikuchepetsa.
• Hypolipidemic - miyeso yofuna kuchepetsa kuchuluka kwa zamadzimadzi m'magazi, kumachepetsa chiopsezo cha zolembedwa za atherosselotic pamakoma a chotengera.

Amakhulupirira kuti thioctic acid ndi antioxidant wamkati wamphamvu yemwe amayamba kugwira ntchito atangodutsa m'mimba.

Alfa-lipoic acid amachepetsa kuchuluka kwa shuga m'magazi ndikuwonjezera gawo la insulin kukana. Mwa kukulitsa kuchuluka kwa glucose komwe thupi limatulutsa, zimapangitsa kuti glycogen ifike m'magazi a chiwindi. Mwa mphamvu zake, thioctic acid ndi wofanana ndi mavitamini a B, amatenga shuga m'magazi komanso mafuta m'thupi, chifukwa cha kusintha kwa cholesterol kukhala mawonekedwe osakhala owopsa (cholesterol metabolism) amathandizira magwiridwe otupa a hepatic.

Chithandizo chogwiritsa ntchito pamapiritsi ndi makapisozi chimatengedwa mwachangu m'magazi, koma ziyenera kukumbukiridwa kuti kugwiritsa ntchito munthawi yomweyo zamankhwala ndi chakudya kumachedwetsa kuyamwa kwa zigawo zamankhwala. Kuzindikira kwambiri m'thupi kumawonedwa mphindi makumi atatu ndi makumi atatu ndi zisanu atamwa.

Mosasamala mtundu wa kasamalidwe (pakamwa kapena kulowetsedwa), Oktolipen 600 imakonzedwa mu chiwindi ndikuchotseredwa ndi impso pafupifupi kwathunthu - osapitilira 10 peresenti yotsalira m'thupi pambuyo theka la moyo - mphindi makumi asanu ndi awiri.

Contraindication

Mankhwala "Oktolipen 600", analogi ndi zinthu zina zofananira zamagulu ena amtundu wa mankhwala ali ndi zochepa zotsutsana. Zotsatsira zimapereka maumboni anayi osakhala apadera:

• Kukhalapo kwa hypersensitivity kwa yogwira mankhwala osokoneza bongo, nthawi zambiri - kwa yachiwiri.
• Nthawi yapakati.
• Mkaka kudyetsa mwana.
• Zaka za ana mpaka zaka zisanu ndi chimodzi.

Zotsatira zoyipa

Mankhwalawa "Oktolipen 600" ali ndi zotsatira zoyipa, koma ambiri aiwo samaganiziridwa, chifukwa izi zimachitika pocheperapo kuposa m'modzi mwa anthu mazana atatu. Zodziwika kwambiri mwa izo ndi monga:

• Thupi lawo siligwirizana (kuyambira urticaria yaying'ono ndi / kapena kuyabwa pa malo kukhudzana ndi mankhwalawa ndi mucosa kuti edema ya kupuma thirakiti ndi anaphylactic mantha.
• Zotsatira zoyipa zam'mimba zimayang'aniridwa kawirikawiri, kuphatikizapo kusanza, kuyaka m'mimba, ndi mseru.
• Chochitika chodziwika bwino ndizizindikiro za shuga wochepa wamagazi (hypoglycemia): kutopa, chizungulire, kugona, komabe, onse amachotsedwa pakumwa supuni ya shuga.

Malamulo Ovomerezeka

"Mungatenge bwanji Oktolipen 600?" Ogula ambiri amafunsa. Odwala omwe adalandira mankhwala "Oktolipen 600" ayenera kutsatira zotsatirazi: piritsi limodzi limatengedwa theka la ola musanadye pamimba yopanda kanthu (kudzuka - kumwa piritsi - kudikirira - kudya).

Mulingo umodzi tsiku lililonse wa ma milligram 600 amalembedwa: piritsi limodzi kapena awiri. Nthawi yomweyo, nthawi yoyang'anira ndi kumwa mankhwalawa imakhala udindo wa dokotala, ndipo amatha kusintha malingana ndi matendawa.

Kuti muwonjezere mphamvu yonse kwa odwala kwambiri, mankhwalawa amapatsidwa mankhwala osokoneza bongo kwa pafupifupi milungu itatu. Kenako, pambuyo pa nthawi imeneyi, wodwalayo amasamutsidwa pamankhwala ambiri: piritsi limodzi patsiku.

Kwa makina kudzera pa dontho, kukonzekera kumakonzedwa malinga ndi tekinoloje zotsatirazi: zomwe zili mumodzi kapena awiri a Octolipen 600 ampoules zimasungunuka mu gawo linalake (kuchokera pa 50 mpaka 250 milliliters) a saline yachilengedwe - kuchuluka kwa sodium chloride kufikira kulemera konse kwa osakaniza ndi 0.9 peresenti. Pulogalamu yamatendawa imadyedwa, nthawi zambiri mkati mwa maola awiri, kuyambitsa thupi kumachitika kudzera mwa dontho. Malangizo oterewa a njira yothetsera kulowetsedwa amakulolani kulowa m'thupi la wodwala kuchokera mamiligalamu mazana atatu mpaka sikisi a mankhwala "Oktolipen 600".

Malangizo ogwiritsira ntchito, mtengo - zonsezi zimafuna kugwiritsa ntchito mosamala mankhwalawa. Mankhwalawa ali pachiwopsezo chowonjezeka ndi kuwala kwa dzuwa, chifukwa chake ma ampoules a omwe azitsata ayenera kutsegulidwa musanayambe ntchito. Komanso, ngakhale mankhwala omwe amasudzulidwa pakhungu amawola, ndikupanga poizoni. Ndikofunikira kusunga malonda m'malo amdima, owuma, yankho lomalizira limataya katundu ndi chitetezo pambuyo maola 6.

Bongo

Mukalandira mlingo wa Oktolipen 600, Zizindikiro zoyenera zimawonedwa: kupweteka kwambiri pamutu, kuchepa kwa magonedwe ake, komanso kuwonjezeranso mavuto ena monga mseru, kutentha kwa mtima ndi kusanza. Mankhwala amathandizidwa, omwe amathandiza kuthetsa zoipa zomwe zimachitika m'thupi. Itha kutengedwa: analgin, makala ochititsidwa, phokoso lam'mimba ndizovomerezeka, kapena kuyimitsidwa kwa magnesium oxide kuvomerezeka.

Gulu la Nosological (ICD-10)

Kufotokozera za mtundu wa kipimo

Mapiritsi filimu yokutira kuchokera ku chikasu chopepuka mpaka chikasu, chowumbirira, biconvex, chiopsezo mbali imodzi. Pa kink - kuchokera pachikaso chowoneka chikaso.

Makapu: zolimba opaque gelatin makapisozi 0 0 chikasu. Zomwe zili m'mabotolo ndi ufa wamtundu wachikaso kapena wachikaso. Mawonekedwe oyera amaloledwa.

Pharmacokinetics

Mukamamwa pakamwa, imathamanga komanso kumangika m'matumbo, ndipo kudya limodzi ndi chakudya kungachepetse kuyamwa kwa mankhwalawo.

Kumwa mankhwalawa, malinga ndi malingaliro, mphindi 30 chakudya chisanafike popewa kuyanjana kosayenera ndi chakudya, monga mayamwidwe thioctic acid pa nthawi ya ingestion chakudya chatha kale. C_max thioctic acid m'madzi a m'magazi amafikira mphindi 30 atatha kumwa mankhwalawa ndipo ndi 4 μg / ml. Thioctic acid imakhala ndi mphamvu yoyamba kudutsa m'chiwindi. Mtheradi bioavailability wa thioctic acid ndi 20%.

Njira zazikulu za metabolic ndi makutidwe ndi okosijeni ndi kulumikizana. Thioctic acid ndi ma metabolites ake amuchotsa impso (80-90%). T_1/2 - mphindi 25

Mimba komanso kuyamwa

Kugwiritsa ntchito mankhwalawa pa nthawi ya pakati kumapangidwa pakakhala kuti palibe mokwanira pazachipatala za thioctic acid pa nthawi yapakati.

Maphunziro owonjezera poizoni sanawululire zoopsa za chonde, zotsatira za kakulidwe ka fetus, komanso mphamvu iliyonse ya mimbayo.

Kugwiritsa ntchito kwa mankhwala Oktolipen ® pa mkaka wa m`mawere kumapangidwa chifukwa chosowa deta pakulowerera kwa thioctic acid mkaka wa m'mawere.

Malangizo apadera

Odwala omwe amatenga Oktolipen ® ayenera kupewa kumwa mowa, monga kumwa mowa ndi chiopsezo chotukuka kwa polyneuropathy ndipo kungachepetse kuthandizira kwa mankhwalawa.

Chithandizo cha matenda ashuga polyneuropathy ziyenera kuchitika uku kukhalabe ndi kuchuluka kwa shuga m'magazi.

Kukopa pa luso loyendetsa magalimoto ndi zida. Zowonjezera pa kuthekera koyendetsa magalimoto ndi maginito sanaphunzitsidwe mwachindunji. Chisamaliro chikuyenera kuthandizidwa poyendetsa magalimoto ndi kuchita zinthu zoopsa zomwe zimafuna kuti anthu azikhala ndi chidwi kwambiri komanso azithamanga.

Kutulutsa Fomu

Mapiritsi okhala ndi mafilimu, 600 mg. Mapiritsi 10 mu mapaketi otumphuka opangidwa ndi PVC film kapena ma PVC / PVDC, kapena PVC / PE / PVDC ndi foil aluminiyamu.

3, 6, 10 matuza amayikidwa mu paketi ya makatoni.

Makapisozi, 300 mg. Mu matuza a blister, 10 ma PC. 3 kapena 6 ma contour mapaketi okhala mukatoni.

Wopanga

Mwa kupanga ku JSC Pharmstandard-Tomskkhimfarm

Pharmstandard-Tomskkhimfarm OJSC 634009, 211 Lenin Ave., Tomsk, Russia.

Tel./fax: (3822) 40-28-56.

Ndikupanga ku JSC Pharmstandard-Leksredstva

Pharmstandard-Leksredstva OJSC, 305022, Russia, Kursk, ul. 2 Aggregate, 1a / 18.

Tele./fax: (4712) 34-03-13.

Makapisozi OJSC Pharmstandard-Leksredstva, 305022, Russia, Kursk, ul. 2 Aggregate, 1a / 18.

Tele./fax: (4712) 34-03-13.

Mitu ya mankhwalawa

Mankhwala abwino kuchokera pagululi ndi Oktolipen 600. Malangizo ogwiritsira ntchito, mtengo - zonsezi zikusonyeza kuti chida ichi ndi chabwino komanso chothandiza chofanana ndi mankhwala ambiri, monga Berlition ndi Neuroleepone - oyimira ambiri a gulu lomweli la mankhwala.

Ndemanga makasitomala

"Oktolipen 600" ali ndi ndemanga zambiri zabwino, monga lamulo, odwala ambiri amayamikira kwambiri mankhwalawa - ndiotsika mtengo kwambiri kuposa "Berlition", koma othandiza kwambiri kuposa "NeroLipon", chifukwa chake ndiofunika kugula ndi mankhwala.

Mankhwala okhathamira amagulitsidwa pamtengo wamba wa ma ruble 380, ndipo mapiritsi ndi makapisozi omwe amaperekedwa ndi mankhwala a dotolo ali ndi mtengo wa ma ruble 290-300.

Ndipo kumbukirani - samalani thanzi lanu. Osadzilimbitsa, mapiritsi a Oktolipen 600 ayenera kumwedwa kokha atakumana ndi dokotala. Kudziyendetsa nokha popanda kumwa mankhwala kwa dokotala kumatha kubweretsa zovuta zina ku thanzi lanu, ngakhale kufa.

Ntchito malangizo Okolipen

Pofuna kuthana ndi zizindikiro za matenda ashuga, dokotala amatha kukupatsani mankhwala Okolipen.

Odwala ayenera kudziwa momwe mankhwalawa alili odabwitsa komanso momwe amakhudzira thupi.

Kuphatikiza apo, muyenera kudziwa zomwe mankhwalawa angakupatseni zovuta. Izi zikuthandizira kupewa zinthu zolakwika ndikuwonjezera luso la mankhwala.

Zambiri

Oktolipen amachokera pa thioctic acid. Nthawi zina mankhwalawa amatchedwa lipoic acid, chifukwa amakhala ndi chinthu chomwecho. Mankhwalawa cholinga chake ndikuchotsa matenda ambiri.

Ili ndi zinthu zingapo zothandiza:

• hepatoprotective
• achina,
• neuroprotective
• hypocholesterolemic.

Mutha kudziwa chifukwa chake Oktolipen adayikidwa, kuchokera pamalangizo. Ndizoyenera kuthandizira odwala matenda ashuga, koma palinso ma pathologies ena omwe amathandizira kuti athetse.

Dokotala amayenera kukupatsani mankhwala. Atha kuwunika momwe angagwiritsire ntchito panthawi inayake, kusankha mlingo woyenera ndikuwunika momwe mankhwalawo alili.

Oktolipen amapangidwa ku Russia. Kuti mugule mankhwalawa mufakisoni muyenera kupereka mankhwala.

Kuphatikizika, mawonekedwe omasulidwa

Mankhwalawa amapezeka m'mitundu ingapo (makapisozi, mapiritsi, jekeseni). Kusankhidwa kwa mitundu yosiyanasiyana ya mankhwalawa kumatengera mawonekedwe amthupi la wodwalayo komanso mtundu wa matendawo. Ntchito zazikuluzikulu za Octolipen ndi thioctic acid, yomwe ndi gawo lalikulu.

Mapiritsi ndi makapisozi amawonjezera zinthu monga:

• calcium hydrogen phosphate dihydrate,
• mankhwala a gelatin
• olimba ndi magnesium,
• titanium dioxide
• silika
• utoto.

Mapiritsi ndi makapisozi ndiosiyanasiyana. Mlingo wa chinthu chogwira ntchito mwa iwo ndi 300 ndi 600 mg. Amagulitsidwa m'mapaketi a 30 ndi 60 unit.

Njira yothetsera imakhala m'malo amadzimadzi, ilibe mtundu ndipo ndi yowonekera.

Zothandiza pazomwe zimapangidwira ndi:

Kuti zitheke, mitundu iyi ya Oktolipen imayikidwa mu ma ampoules.

Pharmacology ndi pharmacokinetics

Gawo lomwe limagwira limakhudza thupi kwambiri. Mukamamwa odwala, ndende ya magazi imachepa, chifukwa thioctic acid imakulitsa mphamvu ya insulin. Momwemo, glucose amatengeka ndi maselo ndikugawa minofu.

Acid imalepheretsa zomwe zimapangitsa kuti tizilombo toyambitsa matenda tizilombo toyambitsa matenda, tidziyeretsa thupi la poizoni komanso imathandizira kulimbitsa chitetezo chokwanira. Chifukwa cha izo, kuchuluka kwa cholesterol yafupika, yomwe imalepheretsa kukula kwa atherosulinosis. Kuphatikiza apo, asidi amathandizira ntchito ya chiwindi, imakhudza kayendedwe ka lipid ndi carbohydrate metabolism.

Mukamamwa pakamwa, gawo lochizira limamwetsedwa ndikugawa mwachangu. Kuchuluka kwa ndende kumafika patadutsa mphindi 40. Kuchita bwino kwambiri kumatheka ndi jakisoni. Njira yotsitsimutsa imakhudzidwa ndi nthawi yakudya - ndikofunika kugwiritsa ntchito mankhwalawa musanadye.

Acid imakonzedwa ndi chiwindi. Zambiri mwa zinthuzi zimachotsedwa m'thupi kudzera mu impso. Hafu ya moyo imatenga ola limodzi.

Kanema wokhudzana ndi asidi a thioctic acid:

Zizindikiro ndi contraindication

Kugwiritsa ntchito mankhwalawa mankhwala osokoneza bongo kapena kugwiritsa ntchito popanda chifukwa kungavulaze wodwalayo.

Zotsatira zamankhwala:

• polyneuropathy chifukwa cha matenda osokoneza bongo kapena uchidakwa (mankhwalawa amachitika pogwiritsa ntchito mapiritsi),
• poyizoni ndi chakudya kapena zinthu zoopsa,
• matenda a chiwindi
• Hyperlipidemia,
• hepatitis mtundu A (muzochitika izi, kugwiritsidwa ntchito kwa yankho la jakisoni kumaperekedwa).

Komanso, mankhwalawa atha kulimbikitsidwa pamatenda omwe samapezeka mndandanda wazisonyezo. Izi zimaloledwa mu zovuta mankhwala.

Kupezeka koyenera koyenera ndi kofunikira kwambiri, koma kusapezeka kwa zotsutsana kumawonedwa ndikofunikira kwambiri. Ngati apezeka, kugwiritsa ntchito Oktolipen ndizoletsedwa.

Contraindations akuphatikiza:

• tsankho pamagawo ena
• kubala mwana
• kudya kwachilengedwe
• zaka za ana.

Zikatero, Octolipen wa mankhwalawa amafunafuna m'malo mwake pakati pa analogues.

Odwala Apadera ndi Mayendedwe

Popereka mankhwala kwa anthu ena, muyenera kusamala, chifukwa thupi lawo limatha kuyankha mosagwirizana ndi mankhwalawa.

Zina mwa izo ndi:

1. Amayi oyembekezera. Malinga ndi kafukufuku, thioctic acid sikuvulaza mwana wosabadwayo ndi mayi woyembekezera, koma tsatanetsatane wazotsatira zake sizinaphunzire mwatsatanetsatane. Chifukwa chake, madokotala amapewa kupereka mankhwala Oktolipen panthawiyi.
2. Akazi omwe amachita kudya kwachilengedwe. Palibe chidziwitso kuti ngati mankhwalawa amayamba kulowa mkaka wa m'mawere. Pankhaniyi, pakubala, chida ichi sichikugwiritsidwa ntchito.
3. Ana ndi achinyamata. Sizinali zotheka kukhazikitsa mphamvu ndi chitetezo cha thioctic acid m'gulu ili la odwala, ndichifukwa chake mankhwalawa amawonedwa kuti ndi otsutsana nawo.

Odwala ena amatha kugwiritsa ntchito mankhwalawa ngati alibe tsankho.

Pogwiritsa ntchito Oktolipen mwa anthu omwe ali ndi matenda ashuga, munthu ayenera kukumbukira luso la thioctic acid kuti achepetse kuchuluka kwa shuga.

Izi zimatha kupititsa patsogolo zotsatira za othandizira ena a hypoglycemic ngati wodwala atatenga. Chifukwa chake, muyenera kuwunika mwadongosolo mulingo wamagazi ndikusintha Mlingo wa mankhwala mogwirizana ndi iwo.

Chofunikira china cha mankhwalawa ndikusokoneza kwake momwe amathandizira mowa. Motere, akatswiri amaletsa kumwa mowa panthawi yamankhwala.

Palibenso chidziwitso momwe Oktolipen amathandizira pazomwe zimachitika komanso kuchuluka kwa zomwe amachita. Popewa zoopsa zomwe zingachitike, chisamaliro chikuyenera kuthandizidwa poyendetsa galimoto ndi poopsa.

Kuyanjana Ndi Mankhwala Ndi Analogi

Kuti mankhwalawa akhale opindulitsa, muyenera kuganizira zotsatirazi:

• Oktolipen amathandizira zotsatira za othandizira a hypoglycemic and insulin,
• tikamwa pamodzi, mankhwalawa amachepetsa mphamvu ya Cisplatin,
• Zokonzekera zomwe zimakhala ndi chitsulo, magnesium kapena calcium ziyenera kumwedwa isanachitike kapena itatha Oktolipen ndi malire a maola angapo,
• mankhwalawa amalimbikitsa mphamvu za anti-yotupa zama glucocorticosteroids,
• mothandizidwa ndi mowa, mphamvu ya Octolipen imatsika.

Pankhaniyi, ndikofunikira kusintha mlingo wa mankhwalawa ndikukhala ndi nthawi yoyikidwa. Ngakhale ndibwino kupewa kuphatikiza mankhwalawa ndi njira zosayenera.

Nthawi zina odwala amakana kumwa mankhwalawa ndipo amapemphedwa kuti asankhe motchipa zotsika mtengo. Nthawi zina, m'malo amafunika chifukwa cha vutoli.

Mankhwala osokoneza bongo amaphatikizapo:

Kusankha kwa m'malo mwa Oktolipen kuyenera kuchitika ndi othandizira azaumoyo.

Maganizo a akatswiri ndi odwala

Malinga ndi ndemanga za madotolo za mankhwala a Okolipen, titha kunena kuti atha kupatsidwa mankhwala othandizira kuchepetsa thupi. Pankhani ya matenda ashuga, mwayi wokhala ndi zovuta za mtundu wa hypoglycemia ndiwokwera.

Kuunika kwa wodwala kumatsutsana kwambiri - mankhwalawa amathandizira kuchepetsa kunenepa, koma amadziwika ndi zovuta zina pafupipafupi.

Ndikulembera Oktolipen kwa odwala anga mosalekeza. Oyenera ena, ena ayi. Chida chimathandizira poyizoni, kutsika shuga, amayi amafunsidwa kuti apereke mankhwala kuti achepetse thupi. Koma, monga ndi mankhwala aliwonse, muyenera kusamala nawo chifukwa cha contraindication ndi zotsatira zoyipa.

Ekaterina Igorevna, dokotala

Ndikupangira Oktolipen ndi fanizo lake kwa odwala onenepa kwambiri - mu izi zimathandizadi. Sindikulimbikitsa kugwiritsa ntchito odwala matenda ashuga. Ngati agwiritsa ntchito mankhwala a hypoglycemic, ndiye kuti Oktolipen angayambitse zovuta.

Irina Sergeevna, dokotala

Sindimakonda mankhwalawa. Chifukwa cha ichi, shuga anga adatsika kwambiri - adokotala sanatchere khutu kuti ndine wodwala matenda ashuga. Chifukwa cha hypoglycemia, ndinakafika kuchipatala. Anthu ena omwe timawadziwa amatamanda mankhwalawa, koma sindikufuna kuyika pachiwopsezo.

Ntchito Okolipen pakuchepetsa thupi. Sabata yoyamba ndimakhala wopanda nkhawa; Kenako ndinazolowera. Ndinkakonda zotsatira - m'miyezi iwiri ndinachotsa 7 kg.

Kuti mugule mankhwalawa m'mapiritsi, muyenera kuchokera kuma ruble 300 mpaka 400. Mapiritsi (600 mg) amawononga ma ruble 620-750. Mtengo wonyamula Oktolipen ndi ma ampoules khumi ndi ma ruble 400-500.

Zisonyezo za Oktolipen

Mankhwala Okolipen, malangizo ntchito angagwiritse ntchito mankhwalawa polyneuropathy a matenda ashuga ndi mowa.

Amagwiritsidwanso ntchito pamayendedwe otsatirawa:

• Hepatitis
• Cirrhosis
• Neuralgia ya kutukuka kosiyanasiyana,
• Kulimbitsa thupi ndi mchere wazitsulo zolemera.

Ndemanga zambiri za Oktolipen zikuwonetsa kuti imagwiritsidwa ntchito osati ma polyneuropathies okha, komanso zochitika zosiyanasiyana pamene dongosolo lamanjenje limafunikira thandizo.

Malangizo ogwiritsira ntchito Oktolipen, mlingo

Mlingo umasiyana kwambiri: 50-400 mg / tsiku. Nthawi zina adotolo amakupereka mpaka 1000 mg, koma izi, ndizosiyana.

Malangizo a Oktolipen salimbikitsa kupitirira mlingo wa 600 mg.

Stepwise mankhwala n`zotheka: m`kamwa makonzedwe a mankhwala akuyamba pambuyo 2-4-milungu maphunziro a makolo (kulowetsedwa) makonzedwe a thioctic acid. Njira yayikulu yotsatirira mapiritsi ndi miyezi itatu.

Kukonzekera yankho, 300-600 mg ya mankhwalawa imasungunuka mu sodium chloride, mankhwalawa amaperekedwa kudzera m'mitsempha. Njira zochizira zimachitika kamodzi patsiku kwa milungu iwiri, inayi. Pambuyo pake, chithandizo cham'kamwa (pakamwa) chimawonetsedwa.

Oktolipen mu mawonekedwe a makapisozi amathandizidwa pakamwa pa 600 mg (2 zisoti.) 1 nthawi / tsiku. Makapisozi amatengedwa m'mawa, pamimba yopanda kanthu, mphindi 30 asanadye kaye koyamba, osafuna kutafuna, kumwa madzi ambiri. Kutalika kwa maphunzirowa kumatsimikiziridwa ndi adokotala okha.

Zolemba zogwiritsira ntchito

Odwala omwe amapezeka ndi matenda osokoneza bongo amafunika kuwunika momwe kuchuluka kwa shuga m'magazi, makamaka koyambirira kwa chithandizo ndi Okolipen.

Palibe deta pazakuthira kwa thioctic (α-lipoic) acid pa kuyendetsa bwino magalimoto ndi magalimoto.

Ngati mtsempha wa intravenous / kulowetsedwa kuchitidwa mwachangu, pali ngozi yowonjezera kukakamira, kuwonekera kwa mavuto ndi kupuma, komanso kugwidwa. Chifukwa cha kukhudzidwa ndi Oktolipen pa kupatsidwa zinthu za m'magazi, zotupa, zotupa zotupa pakhungu ndi mucous nembanemba zimatheka.

Kugwiritsa ntchito nthawi yomweyo kumachepetsa mphamvu ya mankhwalawa.

Mankhwalawa ndi othandizira kupepuka, kotero ma ampoules amayenera kumwedwa pokhapokha asanagwiritse ntchito, ndiye kuti, asanalowe.

Odwala omwe amatenga Oktolipen sayenera kumwa zakumwa zilizonse zakumwa zoledzeretsa, monga Mowa ndi metabolites ake amachepetsa kuchiritsa kwa thioctic acid.

Mukamamwa mankhwala a Okolipen, kugwiritsa ntchito mankhwala a mkaka osavomerezeka (chifukwa cha zomwe zili ndi calcium). The pakati pakati Mlingo ayenera kukhala osachepera 2 maola.

The munthawi yomweyo mankhwala a Oktolipen ndi kukonzekera chitsulo, magnesium ndi kashiamu ali osavomerezeka (chifukwa mapangidwe zovuta ndi zitsulo, imeneyi pakati Mlingo ayenera osachepera maola 2).

Analogs Okolipen, mndandanda

• Tiolepta
• Tiogamma
• Espa lipon
• Alpha lipoic acid,
• Malipidwe,
• Lipamide
• Lipothioxone
• Neuroleipone.

Chofunikira - malangizo ogwiritsira ntchito Oktolipen, mtengo ndi kuwunika kwa analogues sizogwirizana ndipo sizingagwiritsidwe ntchito ngati chitsogozo kapena malangizo. Kusintha kulikonse kwa mankhwala Okolipen ndi analog kuyenera kuyang'aniridwa ndi adokotala. Ngakhale kuti mankhwalawa ndi mawonekedwe ake amagwiritsidwa ntchito nthawi zambiri ndi amayi kuti achepetse kunenepa, dokotala wodziwa bwino ayenera kukuchenjezani pazoyesazi, pokhapokha ngati ndikuphwanya zakudya zamatenda komanso mapuloteni, komanso kukonza kulemera kwa odwala matenda ashuga.