Insuman® Basal GT

Insuman Basal GT 100 I.U./ml

Nambala yolembetsa: P No. 011994/01 ya Julayi 26, 2004

Kupanga

1 ml ya kuyimitsidwa kosaloledwa kwa jakisoni ali ndi 100 IU ya insulin ya anthu (100% crystalline insulin protamine).
Omwe amathandizira: protamine sulfate, m-cresol, phenol, zinc chloride, sodium dihydrogen phosphate dihydrate, glycerol, sodium hydroxide, hydrochloric acid, madzi a jekeseni.

Mankhwala:

Contraindication

• achina,
• Hypersensitivity reaction insulin kapena mankhwala ena aliwonse othandizira, kupatula milandu yomwe insulin chithandizo ndiyofunika. Zikatero, kugwiritsa ntchito Insuman Bazal GT kumatheka pokhapokha kuyang'aniridwa mosamala ndipo ngati kuli koyenera, kuphatikiza ndi anti-allergen.

Njira zopewera komanso malangizo apadera

N`zotheka mtanda-immunological zochita za anthu insulin ndi insulin ya nyama. Ndi kukhudzika kowonjezereka kwa wodwala kuti apange insulin yakuchokera kwa nyama, komanso m-cresol, kulekerera kwa Insuman Bazal GT kuyenera kuwunikira kuchipatala pogwiritsa ntchito mayeso a intradermal. Ngati pakuyesedwa kwa insulin ya insulin ya munthu kumadziwika, zotsatira zake, monga Arthus, ndiye kuti chithandizo china chikuyenera kuyang'aniridwa ndi achipatala. Mwa kuchuluka kwakukulu kwa odwala omwe ali ndi hypersensitivity kupita ku insulin ya nyama, ndizosavuta kusinthana ndi ma insulin aumunthu chifukwa cha mtanda wa immunological wa insulini ya anthu ndi insulin yochokera ku nyama.
Hypoglycemia imatha kukhazikika ngati kuchuluka kwa insulini kudutsa kofunikira kwambiri.
Pali zisonyezo zina zamankhwala ndizizindikiro zomwe zimayenera kuwonetsa kwa wodwala kapena ena za kutsika kwakuthwa kwa shuga. Izi ndi monga: thukuta la mwadzidzidzi, kuluma, kugwedezeka, kugona, kugona, kusokonezeka kwa tulo, mantha, kukhumudwa, kusakhazikika, zosadziwika bwino, nkhawa, paresthesia mkamwa komanso kuzungulira pakamwa, kutsekemera, kupweteka mutu, kusowa kwa mgwirizano wogwirizira komanso kuyenda kwakanthawi. kusokonezeka kwa mitsempha (kufooka kwa mawu ndi masomphenya, zizindikiro za paralo) komanso zomveka zachilendo. Ndi kutsika kwakukwera m'magulu a shuga, wodwalayo amatha kulephera kudziletsa komanso ngakhale kuzindikira. Zikatero, kuzizira ndi chinyezi pakhungu kumatha kuonedwa, ndipo kupweteka kumawonekeranso.
Odwala ambiri, chifukwa cha mayendedwe a adrenergic, amatha kukhala ndi zizindikiro zotsatirazi, zomwe zikuwonetsa kuchepa kwa magazi: kutuluka thukuta, chinyezi cha khungu, nkhawa, tachycardia (palpitations), kuthamanga kwa magazi, kugwedezeka, kupweteka pachifuwa, kusokonezeka kwa mtima.
Chifukwa chake, wodwala aliyense yemwe ali ndi matenda ashuga komanso kulandira insulin ayenera kuphunzira kuzindikira zizindikiro zosadziwika zomwe ndi chizindikiro cha kukhala ndi hypoglycemia. Odwala omwe amawunika shuga ndi mkodzo pafupipafupi sangakhale ndi hypoglycemia. Kukonda kwambiri hypoglycemia kumatha kulepheretsa wodwala kuyendetsa galimoto komanso kugwiritsa ntchito makina aliwonse. Wodwala amatha kukonza kuchepa kwa shuga komwe adazindikira mwa kudya shuga kapena zakudya zambiri zamagulu ochulukirapo. Pazifukwa izi, wodwalayo ayenera kukhala ndi 20 g shuga nthawi zonse. Mokulira kwambiri kwa hypoglycemia, jakisoni wokhazikika wa glucagon akuwonetsedwa (omwe angathe kuchitidwa ndi dokotala kapena antchito oyamwitsa). Pambuyo pakusintha kokwanira, wodwalayo ayenera kudya. Ngati hypoglycemia singathetsedwe mwachangu, ndiye kuti dokotala akuyenera kuyitanidwa mwachangu.Ndikofunikira kudziwitsa dokotala mwachangu za kukula kwa hypoglycemia kuti apange chisankho pakufunika kusintha kwa insulin.
Nthawi zina, zizindikiro za hypoglycemia zimatha kukhala zofowoka kapena kusapezeka. Zochitika zotere zimachitika kwa odwala okalamba, pamaso pa zotupa zamanjenje (neuropathy), odwala matenda amiseche, othandizira ena ndi mankhwala ena (onani "Kuyanjana ndi mankhwala ena"), okhala ndi shuga yochepa kwambiri posintha insulin.
Zotsatira zotsatirazi ndizotheka kuchepa kwambiri kwa shuga m'magazi: kuchuluka kwa insulin, jakisoni wosayenera wa odwala (odwala okalamba), kusinthana ndi mtundu wina wa insulin, kudumpha chakudya, kusanza, kutsegula m'mimba, kuchita masewera olimbitsa thupi, kuchepetsa nkhawa, kumwa mowa, ndi matenda omwe amachepetsa kufunika mu insulin (chiwindi chachikulu kapena matenda a impso, kuchepa kwa ntchito ya adrenal cortex, pituitary kapena chithokomiro), kusintha kwa jekeseni (mwachitsanzo, khungu la pamimba, phewa kapena ntchafu), komanso mogwirizana ndi mankhwala ena mothandizidwa ndi mankhwala (onani "Kuyanjana ndi mankhwala ena")
Chiwopsezo cha kukhala ndi hypoglycemia ndi chachikulu pamayambiriro a chithandizo cha insulin, mukasinthira kukonzekera kwina kwa insulin, mwa odwala omwe ali ndi shuga ochepa.
Gulu lowopsa lomwe lili ndi odwala omwe ali ndi zigawo za hypoglycemia komanso kuchepa kwa ziwalo za ziwalo za ziwalo za ziwalo za ziwalo zake ziwalo (ziwalo za ziwalo za ziwalo za ziwalo za ziwalo za ziwalo).
Kulephera kutsatira zakudya, kudumpha jakisoni wa insulin, kuchuluka kwa insulin chifukwa cha matenda opatsirana kapena matenda ena, komanso kuchepa kwa zochitika zolimbitsa thupi kungayambitse kuchuluka kwa shuga m'magazi (hyperglycemia), mwina ndi kuchuluka kwa matupi a ketone m'magazi (ketoacidosis). Ketoacidosis imatha kumatha maola ochepa kapena masiku. Pazizindikiro zoyambirira za metabolic acidosis (ludzu, kukodza pafupipafupi, kulephera kudya, kutopa, khungu lowuma, kupuma kwambiri komanso kuthamanga, chidwi cha acetone ndi glucose mkodzo), chithandizo chamankhwala chofunikira ndichofunikira.
Pakusintha dokotala (mwachitsanzo, nthawi yakuchipatala chifukwa cha ngozi, kudwala panthawi ya tchuthi), wodwalayo ayenera kudziwitsa dokotala kuti ali ndi matenda ashuga.

Mimba komanso kuyamwa

Chithandizo cha Insuman Bazal GT ziyenera kupitilizidwa pa nthawi yapakati. Pa nthawi yoyembekezera, makamaka pambuyo pa trimester yoyamba, kuwonjezereka kwa insulin kuyenera kuyembekezeredwa. Komabe, pambuyo pobadwa, kufunika kwa insulin nthawi zambiri kumatsika, komwe kumabweretsa chiwopsezo chachikulu cha hypoglycemia. Ngati muli ndi pakati kapena mukufuna kubereka, onetsetsani kuti mwadziwitsa dokotala.
Panthawi yoyamwitsa, palibe malamulo oletsa insulin. Komabe, kusintha kwa mlingo ndi kadyedwe kungafunikire.

Gulu la Nosological (ICD-10)

Insulin Insuman Bazal GT - malangizo ogwiritsira ntchito

Kuchiza matenda a shuga nthawi zambiri kumafuna kugwiritsa ntchito mankhwala okhala ndi insulin. Izi zikuphatikizapo Insuman Bazal GT. Ndikofunika kudziwa kuti ndi zinthu ziti zomwe ali nazo komanso mawonekedwe ake, kuti njira zochizira matendawa zizigwira ntchito komanso zotetezeka.

Wopanga mankhwalawa ndi France.Chida ndi cha gulu la hypoglycemic. Adapangidwa pamaziko a insulin yaumunthu ya semisynthetic chiyambi. Kugulitsa komwe kumapezeka ngati mawonekedwe a kuyimitsa jakisoni. Kutalika kwazinthu zomwe zikugwiririka ndizochepa.

Kuphatikiza pa gawo lokangalika, zinthu zina zimaphatikizidwa ndi mankhwalawa zomwe zimapangitsa kuti ntchito zake ziziyenda bwino.

Izi zikuphatikiza:

• madzi
• nthaka ya chloride
• phenol
• protamine sulfate,
• sodium hydroxide
• glycerol
• metacresol
• dihydrogen phosphate sodium dihydrate,
• hydrochloric acid.

Kuyimitsidwa kuyenera kukhala komwe. Mtundu wake nthawi zambiri umakhala yoyera kapena pafupifupi yoyera. Gwiritsani ntchito mobisa.

Mutha kusankha imodzi mwazinthu zoyenera zomwe zimapezeka pamsika:

1. 3 ml cartridgeges (paketi ya ma 5 ma PC.).
2. Makatoni oikidwa mu zolembera za syringe. Kuchuluka kwawo ndi 3 ml. Cholembera chilichonse cha syringe ndi chitha kutulutsa. Mu phukusi pali 5 ma PC.
3. 5 ml Mbale. Amapangidwa ndigalasi lopanda utoto. Pazonse, pali mabotolo asanu otere mu paketi.

Gwiritsani ntchito mankhwalawa pokhapokha ngati mukuwongolera katswiri, mukumvera zomwe zikuwonetsa komanso zomwe sangathe. Mutha kuphunziranso za mankhwalawo nokha. Kuti mugwiritse ntchito moyenera, kudziwa kwapadera kumafunika.

Zotsatira zamankhwala aliwonse zimachitika chifukwa cha zinthu zomwe zimapangidwa pakapangidwe kake. Ku Insuman Bazal, chophatikiza chophatikizika ndi insulin, yomwe imapezeka ndi synthetically. Zotsatira zake ndi zofanana ndi za insulin wamba yopangidwa m'thupi la munthu.

Zokhudza thupi monga motere:

• kuchepetsa shuga
• kukondoweza kwa zotsatira za anabolic,
• Kuchepetsa kuchepa
• imathandizira kufalitsa shuga m'mizimba mwa kuyendetsa mayendedwe ake,
• kuchuluka kwa glycogen,
• kukakamira kwa glycogenolysis ndi glyconeogeneis njira,
• kutsika kwa kuchuluka kwa lipolysis,
• kuchuluka lipogenis mu chiwindi,
• kuthamanga kwa njira ya kaphatikizidwe wa mapuloteni,
• kukondoweza kwa kudya kwa potaziyamu ndi thupi.

Chizindikiro cha chinthu chomwe chikugwira ntchito chomwe ndi maziko a mankhwalawa ndi nthawi yake yochitapo kanthu. Nthawi yomweyo, mphamvu zake sizimachitika nthawi yomweyo, koma zimayamba pang'onopang'ono. Zotsatira zoyambirira zimawonekera ola limodzi pambuyo pa jekeseni. Mankhwala othandiza kwambiri amakhudza thupi pambuyo pa maola 3-4. Zotsatira zamtunduwu wa insulin zimatha kukhala kwa maola 20.

The kuyamwa kwa mankhwala amachokera subcutaneous minofu. Pamenepo, insulin imamangirira ku ma receptor enaake, chifukwa omwe amawagawa minofu yonse. Kuchotsa kwa chinthuchi kumachitika ndi impso, chifukwa chake mawonekedwe awo amakhudza kuthamanga kwa njirayi.

Kugwiritsa ntchito mankhwala aliwonse kuyenera kukhala kotetezeka. Izi ndizofunikira makamaka kwa mankhwala omwe amapereka chithandizo chazidziwitso zofunika, zomwe zimaphatikizapo kuchuluka kwa shuga m'magazi.

Kuti mankhwalawa asavulaze wodwala, muyenera kutsatira malangizo a mankhwalawo ndikugwiritsa ntchito pokhapokha mutazindikira koyenera.

Insuman Bazal imagwiritsidwa ntchito pochiza matenda ashuga. Imafotokozedwa ngati wodwala akufunika kugwiritsa ntchito insulin. Nthawi zina mankhwalawa amagwiritsidwa ntchito limodzi ndi njira zina, koma monotherapy ndi yovomerezeka.

Chofunikira kwambiri pakugwiritsa ntchito mankhwalawa ndikuganizira za contraindication. Chifukwa cha iwo, mankhwalawo osankhidwa amatha kudwalitsa thanzi la wodwalayo, motero dokotala ayenera kuphunzira kaye za anamnesis ndikupanga mayeso ofunikira kuti awonetsetse kuti palibe zoletsa.

Mwa zina zazikulu zotsutsana ndi mankhwala a Insuman amatchedwa:

• kusalolerana insulin,
• tsankho pamagawo othandiza a mankhwalawa.

Mwa zina zoletsedwa zomwe zalembedwa monga:

• mimba
• yoyamwitsa
• kulephera kwa chiwindi
• matenda a impso,
• okalamba ndi ana zaka za wodwalayo.

Milandu imeneyi siyokhala ya kuphwanya malamulo kwambiri, koma madokotala ayenera kusamala popereka mankhwalawo. Nthawi zambiri, njirazi zimakhala ndi cheke cha glucose komanso kusintha kwa mlingo. Izi zimachepetsa chiopsezo cha zotsatira zosafunidwa.

Kuwerenga zomwe zimachitika ndi mankhwala aliwonse, ndikofunikira kudziwa momwe zimakhudzira amayi panthawi yapakati komanso mkaka wa m'mawere.

Kubala mwana nthawi zambiri kumawonjezera kuchuluka kwa shuga kwa amayi omwe akuyembekezera, zomwe zimapangitsa kuti zizindikiritso izi zidziwike. Ndikofunikira kumvetsetsa kuti ndi mankhwala ati otetezeka pamenepa.

Zambiri pazotsatira za Insuman pa mayi wapakati komanso mwana wosabadwa sizinapezeke. Kutengera zambiri zokhudzana ndi mankhwala okhala ndi insulin, titha kunena kuti chinthuchi sichilowa m'matumba, chifukwa chake sichitha kuyambitsa chisokonezo pakukula kwa mwana.

Wodwala yekha ayenera kupindula ndi insulin. Komabe, dokotala wopezekapo amayenera kuganizira zonse za chithunzi cha chipatala ndikuyang'anira kuchuluka kwa shuga. Panthawi yoyembekezera, shuga amatha kusintha kwambiri kutengera nthawi, ndiye muyenera kuwayang'anira, kusintha gawo la insulin.

Ndi chakudya chachilengedwe cha mwana, kugwiritsa ntchito Insuman Bazal kumaloledwa. Gawo lake lothandizira ndi phula la mapuloteni, kotero zikafika kwa mwana limodzi ndi mkaka wa m'mawere, kuvulala sikuwoneka. Thupi limagawika m'migawo ya mwana kuti amino acid ndipo imakamizidwa. Koma amayi akuwonetsedwa zakudya panthawiyi.

Mankhwalawa matenda a shuga. Insuman Bazal ayenera kuganizira zosintha zonse zomwe zimachitika m'thupi la wodwalayo. Sikuti nthawi zonse amakhala olimbikitsa. Monga tafotokozera pakuwunika kwa wodwalayo, mankhwalawa amatha kuyambitsa mavuto ambiri, mfundo yakuchotsa yomwe imadalira mtundu wawo, mphamvu ndi zina. Ngati zikuchitika, kusintha kwa mankhwalawa, mankhwala, komanso kusintha kwa mankhwalawo ndi mawonekedwe ake kungafune.

Chodabwitsachi ndi chimodzi mwazomwe chimakonda kugwiritsa ntchito insulin. Amayamba ngati mlingo wa mankhwalawo wasankhidwa molakwika kapena pamaso pa hypersensitivity wodwala. Zotsatira zake, thupi limadzaza ndi insulin yochulukirapo kuposa momwe iyenera, chifukwa chomwe shugayo imachepetsedwa kwambiri. Zoterezi zimakhala zowopsa, chifukwa milandu yayikulu ya hypoglycemia imatha kupha.

Hypoglycemia imadziwika ndi zizindikiro monga:

• kusokonezeka ndende,
• chizungulire
• njala
• kukokana
• kulephera kudziwa
• kunjenjemera
• tachycardia kapena arrhythmia,
• kusintha kwa kuthamanga kwa magazi, ndi zina zambiri.

Mutha kuthana ndi hypoglycemia wofatsa ndi zakudya zomwe zimakhala ndi mafuta ochulukirapo. Amawonjezera kuchuluka kwa glucose kukhala labwinobwino komanso kukhazikika pansi. Pazovuta zazikuluzikulu izi, chithandizo chachipatala chimafunikira.

Mphamvu ya chitetezo chamthupi ya anthu ena imatha kuyankha mankhwalawa ndi chifuwa. Nthawi zambiri, pofuna kupewa milandu ngati imeneyi, kuyezetsa mayeso koyambirira kumachitika kuti pakhale tsankho.

Koma nthawi zina kugwiritsa ntchito mankhwalawa kumapangidwira popanda mayeso, omwe angayambitse zotsatirazi:

• zotupa pakhungu (edema, redness, zidzolo, kuyabwa),
• bronchospasm
• kutsitsa magazi,
• angioedema,
• anaphylactic mantha.

Zina mwazomwe tatchulazi sizikuwoneka ngati zowopsa. Nthawi zina, kuthetsedwa kwa Insuman kumafunikira, chifukwa wodwala amatha kufa chifukwa chake.

Mankhwala a insulin angayambitse kuwongolera kwa metabolic, chifukwa chomwe wodwalayo amatha kupanga edema. Komanso chida ichi chimayambitsa kuchepa kwa sodium mthupi la odwala ena.

Pa mbali ya ziwalo zooneka, minyewa yolumikizira khungu ndi khungu

Vuto lowoneka limachitika chifukwa cha kusintha kwamwadzidzidzi pakuwerengedwa kwa shuga. Utoto wa glycemic utangokhazikitsidwa, izi zimaphwanya.

Ena mwa mavuto akulu owoneka ndi awa:

• kuchuluka kwa matenda ashuga retinopathy,
• zosokoneza zazifupi
• khungu lakanthawi.

Pankhaniyi, ndikofunikira kwambiri kupewa kusinthasintha kwa shuga.

Choyimira chachikulu chotsutsana ndi minofu ya subcutaneous ndi lipodystrophy. Ndi chifukwa cha jakisoni m'dera lomwelo, zomwe zimayambitsa kusokonezeka kwa mayankho a chinthu chogwira.

Pofuna kupewa izi, tikulimbikitsidwa kusinthana magawo a kaperekedwe ka mankhwala mkati mwa chololedwa pazifukwa izi.

Mawonekedwe a khungu nthawi zambiri amayamba chifukwa cha kulephera kwa thupi kuchizira insulin. Pakapita kanthawi, amachotsedwa popanda kulandira chithandizo, dokotala yemwe akupezekapo ayenera kudziwa za iwo.

Izi zikuphatikiza:

• kupweteka
• redness
• mapangidwe a edema,
• kuyabwa
• urticaria
• kutupa

Zochita zonsezi zimawonekera pokhapokha pena jakisoni.

Mankhwala Insuman amayenera kudyedwa kokha. Imayenera kuyilowetsa mu ntchafu, phewa kapena khoma lamkati lamkati. Popewa kukula kwa lipodystrophy, jekeseni sayenera kupangidwa m'dera lomwelo, malo akuyenera kusinthidwa. Nthawi yoyenera ya jakisoni ndi nyengo ya chakudya chisanafike (pafupifupi ola limodzi kapena pang'ono). Chifukwa chake zitheka kukwaniritsa zokolola zazikulu kwambiri.

Pakatikati, mulingo woyambira ndi magawo 8-24 panthawi imodzi. Pambuyo pake, mankhwalawa amatha kusinthidwa kumtunda kapena pansi. Kutumikiridwa kotheka kovomerezeka kumodzi ndi mitundu 40.

Kusankhidwa kwa mlingo kumakhudzidwa ndi chisonyezo monga chidwi cha thupi pazogwira ntchito za mankhwala. Ngati pali chidwi chachikulu, thupi limakhudzana ndi insulin mwachangu kwambiri, motero odwala otere amafunika gawo laling'ono, apo ayi hypoglycemia ikhoza kukula. Kwa odwala omwe ali ndi chidwi chofuna kupeza chithandizo chokwanira, mlingo uyenera kuchuluka.

Phunziro la kanema pogwiritsa ntchito cholembera:

Pezani wodwala wina mankhwala akhale moyang'aniridwa ndi achipatala. Nthawi zambiri izi zimachitika pofuna kupewa kukula kwa zotsatira zoyipa chifukwa cha contraindication kapena mavuto. Zimachitikanso kuti wodwala sakukondwa ndi mtengo wa Bazal.

Dokotala ayenera kusankha mlingo wa mankhwalawa mosamala kwambiri kuti asayambitse kusinthasintha kwamphamvu mu mbiri ya glycemic - izi ndizowopsa pazotsatira zoyipa. Ndikofunikanso kwambiri kuwona kuchuluka kwa shuga m'magazi kuti asinthe mlingo wa mankhwalawo nthawi kapena kuti mumvetsetse kuti sioyenera kulandira mankhwalawa.

Kusintha Mlingo, Dokotala amayenera kuyesa mphamvu zake. Ngati gawo loyambirira la mankhwalawa silibereka zotsatira, muyenera kudziwa chifukwa chake zimachitika. Pambuyo pokhapokha izi, mlingo umatha kuchuluka, ndikuwongolera njirayi.

Nthawi zina zomwe zimachitika chifukwa cha mankhwalawa zimatha kusakhalapo chifukwa cha zomwe zimachitika mthupi, ndipo nthawi yochulukitsa thupi imayamba chifukwa cha kupezeka kwa zotsutsana. Katswiri yekha ndi amene angadziwe izi.

Pali magulu osiyanasiyana a odwala omwe amafunika kukhala anzeru kwambiri.

1. Amayi oyembekezera komanso oyembekezera. Pokhudzana ndi iwo, ndikofunikira kuwunika mwadongosolo chizindikiro cha shuga ndikusintha gawo la mankhwalawa malinga ndi zotsatira zake.
2. Odwala ndi mkhutu aimpso ndi kwa chiwindi ntchito. Ziwalo izi zimakhudzidwa kwambiri ndi mankhwalawa. Chifukwa chake, pamaso pa pathologies m'derali, wodwala amafunikira kuchepa kwa mankhwalawa.
3. Odwala okalamba. Ndi wodwala wazaka zopitilira 65, nthawi zambiri zimakhala zotheka kudziwa ma pathologies akugwira ntchito ziwalo zosiyanasiyana. Kusintha kokhudzana ndi zaka kungakhudze chiwindi ndi impso.Izi zikutanthauza kuti kwa anthu otere, mlingo wake umayenera kusankhidwa mosamala kwambiri. Ngati palibe ziwonetserozo mu ziwalo izi, ndiye kuti mutha kuyamba ndi gawo labwinobwino, koma muyenera kuyeserera nthawi ndi nthawi. Ngati kulephera kwa impso kapena chiwindi kumayamba, onetsetsani kuti achepetsa kuchuluka kwa insulin

Musanagule Insuman Bazal, muyenera kuonetsetsa kuti izikhala yothandiza.

Kuchuluka kwa mankhwala osavomerezeka kungayambitse mankhwala osokoneza bongo. Nthawi zambiri izi zimabweretsa mkhalidwe wa hypoglycemic, kuuma kwake komwe kungakhale kosiyana kwambiri. Nthawi zina, pakalibe chithandizo chamankhwala, wodwalayo amatha kufa. Ndi mitundu yofooka ya hypoglycemia, mutha kusiya kuukira pogwiritsa ntchito zakudya zamafuta (shuga, maswiti, ndi zina).

Insuman Bazal GT: malangizo ogwiritsa ntchito ndi kuwunikira

Dzina lachi Latin: Insuman Basal GT

Code ya ATX: A10AC01

Zogwira pophika: insulin yaumunthu, isophane (Insulin human, isophane)

Wopanga: Sanofi-Aventis Deutschland, GmbH (Sanofi-Aventis Deutschland, GmbH) (Germany)

Kusintha kufotokozera ndi chithunzi: 11.29.2018

Insuman Bazal GT - insulin yaumunthu ya nthawi yayitali yochita.

Fomu ya Mlingo - kuyimitsidwa kwa kayendetsedwe ka ma subcutaneous (s / c): yosasunthika mosavuta, pafupifupi yoyera kapena yoyera (3 ml iliyonse m'makalata amtundu wamagalasi, 5 makatiriji mumatumba a chithuza, paketi imodzi m'makatoni, 3 ml makatoni galasi lopanda utoto lomwe limayikidwa mu zolembera za SoloStar zotayika, mu makatoni okhala ndi ma syringe 5, 5 ml m'mabotolo amtundu wamagalasi, mu katoni ya mabotolo 5, paketi iliyonse ilinso ndi malangizo ogwiritsira ntchito Insuman Bazal GT).

Muli 1 ml ya kuyimitsidwa:

• ntchito yogwira: insulin-isophan (maumboni amtundu wa anthu) - 100 IU (International Units), yomwe ikufanana ndi 3,571 mg,
• othandizira: glycerol 85%, phenol, metacresol (m-cresol), sodium dihydrogen phosphate dihydrate, zinc chloride, protamine sulfate, madzi a jakisoni, komanso hydrochloric acid ndi sodium hydroxide (kusintha pH).

The yogwira mankhwala Insuman Bazal GT - insulin-isophan imapezeka ndi ma genetic engineering ogwiritsira ntchito E. coli K12 135 pINT90d, mu kapangidwe kake kamafanana ndi insulin yaumunthu.

Mankhwala amachepetsa shuga m'magazi, amachepetsa zotsatira za catabolic ndikulimbikitsa kukula kwa anabolic. Imawonjezera kuyendetsa kwa glucose ndi potaziyamu m'maselo, kumawonjezera kaphatikizidwe ka glycogen m'chiwindi ndi minofu, kumalepheretsa gluconeogeneis ndi glycogenolysis, kumapangitsa kuyenda kwa ma amino acid m'maselo, kaphatikizidwe ka mapuloteni komanso kugwiritsa ntchito kwa pyruvate. Isulin insulin imachepetsa lipolysis, imawonjezera lipogenesis mu chiwindi ndi adipose minofu.

Mphamvu ya hypoglycemic imayamba mkati mwa ola limodzi, imafika pazowonjezera pambuyo pa maola 3-4, imapitirira kwa maola 11 mpaka 20.

Hafu ya moyo wa plasma insulin mwa odzipereka athanzi ili pafupifupi mphindi 4-6, mwa odwala omwe amalephera kupweteka kwa impso, chizindikiro ichi chimawonjezeka.

Ma pharmacokinetics a insulin samawonetsa mphamvu zake za metabolic.

Insuman Bazal GT imagwiritsidwa ntchito pa matenda a shuga omwe amafunikira chithandizo cha insulin.

• achina,
• Hypersensitivity kwa aliyense wothandiza wa mankhwala kapena insulin, pokhapokha ngati mankhwala a insulin afunikira.

Mu milandu yotsatirayi, Insuman Bazal GT iyenera kugwiritsidwa ntchito mosamala (kusintha kwa mankhwalawa ndikuwonetsetsa momwe wodwalayo alili)

• kulephera kwa aimpso
• kulephera kwa chiwindi
• matenda oyamba nawo
• stenosis yamphamvu yam'mimba komanso yam'mimba
• prinosative retinopathy, makamaka kwa odwala omwe sanachitire chithandizo cha Photocoagulation (laser therapy),
• ukalamba.

Zotsatira za pharmacological

Insuman Bazal GT ilinso ndi insulin yofanana ndi insulin yaumunthu ndipo yopezeka ndi ma genetic engineering ogwiritsa ntchito K12 kufinya E. Coli.

- Amachepetsa glucose wamagazi ndikuwonjezera zotsatira za anabolic, komanso amachepetsa zotsatira za catabolic,

- imathandizira kayendedwe ka glucose m'maselo, komanso mapangidwe a glycogen mu minofu ndi chiwindi, zimathandizira kugwiritsa ntchito pyruvate. Imalepheretsa glycogenolysis ndi glyconeogeneis,

- amalimbitsa lipogenesis mu chiwindi ndi adipose minofu ndi ziletsa lipolysis,

- imalimbikitsa kumwa ma amino acid ndi maselo ndikuwonjezera kuphatikiza mapuloteni,

- Imalimbikitsa kumwa potaziyamu ndi maselo.

Insuman Bazal GT (kuyimitsidwa kwa isofan-insulin) ndi insulin yokhala pang'onopang'ono ndikupanga nthawi yayitali. Mphamvu ya hypoglycemic imachitika mkati mwa ola limodzi, ndipo imafikira pakapita maola atatu pambuyo poti mankhwalawa ayende. Zotsatira zimapitirira kwa maola 11 mpaka 20.

Pharmacokinetics

Hafu ya moyo wa seramu insulini m'maphunziro athanzi ndi pafupifupi maminiti 4-6. Kulephera kwambiri kwa impso, kumatenga nthawi. Tiyenera kudziwa kuti pharmacokinetics ya insulin sikuwonetsa metabolic yake.

Zotsatira Zoyesera Za chitetezo

Kafukufuku wokhudzana ndi kawopsedwe wazovuta adachitika pambuyo poyendetsa makina mpaka makoswe. Palibe zoyipa zomwe zapezeka. Kafukufuku wokhudzana ndi pharmacodynamic zotsatira za subcutaneous kayendetsedwe ka mankhwala kwa akalulu ndi agalu adavumbulutsa zomwe zimayembekezereka zimachitika.

Mimba komanso kuyamwa

Palibe maphunziro azachipatala omwe amagwiritsidwa ntchito popanga insulin yaumunthu panthawi yapakati. Insulin siyidutsa chotchinga. Popereka mankhwala kwa amayi apakati, muyenera kusamala.

Pankhani ya odwala preexisting kapena gestationalabetes mellitus, ndikofunikira kusungabe kuchuluka koyenera kwa metabolic panthawi yonse yokhala ndi pakati. Kufunika kwa insulini mu nthawi yoyambirira ya kubereka kumatha kuchepa, koma m'nthawi yachiwiri ndi yachitatu matupi awo amakula. Pambuyo pobadwa, insulin imafunikira imatsika mofulumira (chiwopsezo chowonjezereka cha hypoglycemia). Kuwunikira mosamala kuchuluka kwa shuga m'magazi kumafunika.

Panthawi yoyamwitsa, palibe malamulo oletsa insulin. Komabe, mlingo wa insulin komanso kusintha kwa zakudya kungafunike.

Mlingo ndi makonzedwe

Kusankhidwa kwa shuga wamagazi ofunikira, kukonzekera kwa insulini ndi mlingo wake kwa wodwalayo kumachitika ndi dokotala kutengera zakudya, mulingo wakuchita zolimbitsa thupi ndi moyo. Mlingo wa insulin umatsimikizika potengera kuchuluka kwa shuga m'magazi, komanso pamaziko a kuchuluka kwa zochitika zolimbitsa thupi komanso mkhalidwe wa metabolism ya carbohydrate. Chithandizo cha insulin chimafuna kudziphunzitsa koyenera kwa wodwala. Dokotala amayenera kupereka malangizo ofunikira kangati kuti azindikire kuchuluka kwa shuga m'magazi, komanso apereke malangizo oyenera ngati kusintha kulikonse pakudya kapena muyezo wa insulin.

Mlingo watsiku ndi tsiku ndi nthawi yoyendetsera

Mwachizolowezi, avareji ya tsiku ndi tsiku ya insulin imachokera ku 0,5 mpaka 1.0 ME pa kilogalamu imodzi ya kulemera kwa odwala, pomwe 40-60% ya mlingo wokhala insulin ya anthu. Insuman Bazal GT imakonda kutumikiridwa kwambiri mphindi 45-60 asanadye.

Pambuyo kusintha kusintha

Kuwongolera kuwongolera kwa glycemic kungayambitse kuchuluka kwa insulin, zomwe zingayambitse kuchepa kwa insulin. Kuphatikiza apo, kusintha kwa mlingo kungafunikenso, mwachitsanzo, pakusintha kulemera kwamthupi la wodwalayo,

- posintha moyo wa wodwalayo (kuphatikizapo zakudya, kuchuluka kwa zochitika zolimbitsa thupi, ndi zina zambiri),

- munthawi zina zomwe zimawonjezera chizolowezi chopanga hypoglycemia kapena hyperglycemia (onani malangizo apadera ndi njira zopewera kugwiritsa ntchito).

Ntchito mu magulu apadera amawu

Odwala okalamba ndi odwala omwe ali ndi vuto la impso ndi kwa chiwindi, kufunafuna kwa insulin kungachepe.

Insuman Bazal GT imayendetsedwa mosakakamiza. Mothandizidwa ndi mtsempha wa mankhwalawa samachotsedwa konse!

Kuyamwa kwa insulin ndipo, chifukwa chake, kuchuluka kwa glucose komwe kumapangitsa kuti mankhwalawo athandizidwe kumatha kusiyanasiyana potengera jakisoni (mwachitsanzo, dera la khoma lachiberekero lakumbuyo poyerekeza ndi dera la akazi). Ndi jakisoni aliyense wotsatira, tsamba la jakisidwe liyenera kusinthidwa mkati momwe.

Tsamba la jakisoni liyenera kusinthidwa nthawi iliyonse. Kusintha kwa jekeseni (mwachitsanzo, kuyambira pamimba mpaka ntchafu) kuyenera kuchitika pokhapokha mukaonana ndi dokotala.

Insuman Bazal GT sagwiritsidwa ntchito mitundu yosiyanasiyana ya mapampu a insulini (kuphatikizapo omwe adalowetsedwa).

Musasakanize Insuman Bazal GT ndi insulin ya ndende ina (mwachitsanzo, 40 IU / ml ndi 100 IU / ml), ndi insulin yakuchokera kwa nyama kapena mankhwala ena.

Kumbukirani kuti insulin ndende ya 100 IU / ml (ya ma ml 5 kapena ma 3 ml cartridge), motero, ndikofunikira kugwiritsa ntchito syringes zapulasitiki zokha zomwe zimapangidwira insulin iyi pokhapokha ngati mugwiritsa ntchito mbale, kapena cholembera cha syringe cha OptiPen Pro1. Syringe ya pulasitiki siyenera kukhala ndi mankhwala ena aliwonse kapena zotsalira zake.

Pamaso gawo loyambirira la insulin kuchokera pambale, chotsani kapulasitiki (kukhalapo kwa kapuyo ndi umboni wa vial wosatsutsana). Kuyimitsidwa kuyenera kusakanizidwa bwino nthawi isanakhazikitsidwe, ndipo palibe chithovu chomwe chingapangidwe. Izi zimachitika bwino ndikutembenuza botolo, ndikuligwirizira kumbali yayikulu pakati pa manja. Pambuyo posakanikirana, kuyimitsidwa kumayenera kukhala kosasinthasintha komanso mtundu wamiyala yoyera. Kuyimitsidwa sikungagwiritsidwe ntchito ngati kuli ndi mtundu wina, i.e. ngati ikhala yowonekera bwino kapena masamba kapena mapanga apanga madziwo, pansi kapena kukhoma kwa vial. Zikatero, muyenera kugwiritsa ntchito botolo lina lomwe likugwirizana ndi zomwe zili pamwambapa, ndipo muyenera kudziwitsa dokotala.

Asanatenge insulini kuchokera ku vial, mpweya wofanana ndi mankhwala omwe amaperekedwa ndi insulin umayamwa mu syringe ndikujowina mu vial (osalowa madzi). Kenako vala yokhala ndi syringe imasinthidwa mozungulira ndi syringe ndipo kuchuluka kwa insulini kumatengedwa. Pamaso jakisoni, chotsani thovu lakumanzere mu syringe.

Khungu limatengedwa pamalo a jakisoni, singano imayikidwa pansi pakhungu, ndipo insulin imayamwa pang'onopang'ono. Pambuyo pa jekeseni, singano imachotsedwa pang'onopang'ono ndipo tsamba lamalowo limakanikizidwa ndi swab ya thonje kwa masekondi angapo. Tsiku lokhala ndi insulin kit kuchokera pa vial iyenera kulembedwa pa cholembera cha vial.

Pambuyo pakutsegulira, mabotolo amatha kusungidwa kutentha osaposa +25 ° C kwa milungu 4 m'malo otetezedwa ku kuwala ndi kutentha.

Musanayikitse cartridge (100 IU / ml) mu cholembera cha sytiit ya OptiPen Pro1, siyani iyo iyime kwa maola 1-2 kutentha kwa chipinda. Pambuyo pake, ndikutembenuza mokoma cartridge (mpaka nthawi 10) kuti mupeze kuyimitsidwa kwapadera. Kathumba kalikonse kophatikizira kamakhala ndi mipira itatu yachitsulo posakaniza mwachangu zomwe zili mkati mwake. Mukayika katoni mu syringe cholembera, ndikulowetsani cholembera kambirimbiri pamaso panu jakisoni wa insulin kuti mupeze kuyimitsidwa kwapadera. Pambuyo posakanikirana, kuyimitsidwa kumayenera kukhala kosasinthasintha komanso mtundu wamiyala yoyera. Kuyimitsidwa sikungagwiritsidwe ntchito ngati kuli ndi mtundu wina, i.e. ngati ikhala yowonekera bwino kapena masamba kapena mapampu apanga madziwo, pansi kapena pansi pa makatoni. Zikatero, muyenera kugwiritsa ntchito cartridge ina yomwe ikukwanira pamwambapa, ndipo muyenera kudziwitsa dokotala. Chotsani zotumphukira zilizonse zamagetsi pamkatikati musanabayidwe (onani Malangizo Ogwiritsa Ntchito OptiPen Pro1 Syringe pen).

Katoniyo sanapangire kusakaniza Insuman Bazal GT ndi ma insulini ena. Makatoni opanda kanthu sangakwaniritsidwe.

Pakuswa phala la syringe, mutha kulowa muyezo wofunika kuchokera pa cartridge pogwiritsa ntchito syringe yachizolowezi. Kumbukirani kuti kuchuluka kwa insulini mu cartridge ndi 100 IU / ml, kotero muyenera kugwiritsa ntchito syringes zapulasitiki zomwe zimapangidwira insulin iyi. Syringe siyenera kukhala ndi mankhwala ena aliwonse kapena zotsalira zake.

Pambuyo kukhazikitsa cartridge, itha kugwiritsidwa ntchito - ® kwa> milungu 4. Ndikulimbikitsidwa kusungidwa pa kutentha osapitirira 25 ° C pamalo otetezedwa ku kuwala ndi kutentha. Mukamagwiritsa ntchito cartridge, cholembera sichingasungidwe mufiriji.

Mukakhazikitsa cartridge yatsopano, yang'anani ntchito yoyenera ya cholembera musanalowe jekeseni yoyamba (onani Malangizo ogwiritsira ntchito cholembera cha OptiPen Pro1).

Zotsatira zoyipa

Hypoglycemia, njira yodziwika bwino kwambiri, imatha kupezeka ngati mlingo wa insulin woperekedwa umapitilira kufunikira kwake. Sizingatheke kufotokoza kuchuluka kwa vuto la hypoglycemia, chifukwa kufunika kwa mayesero azachipatala komanso kugwiritsa ntchito mankhwala ogulitsa kumatha kusiyanasiyana malinga ndi kuchuluka kwa anthu komanso kuchuluka kwake. Zochitika zowopsa za hypoglycemia, makamaka ngati zibwerezedwa, zimatha kuyambitsa kukulitsa kwa mitsempha, kuphatikizapo kukomoka, kukokana. Nthawi zina, zochitika ngati izi zitha kupha.

Odwala ambiri, zizindikiro za kuwonongeka kwa hypoglycemic kwa chapakati mantha amayamba ndi zizindikiro za kutsutsana ndi adrenergic. Monga lamulo, momwe kuchuluka kwa glucose m'magazi kumachepera, ndiye kuti tanthauzo la kutsutsana ndi zomwe zimachitika.

Zotsatira zotsatirazi zotsutsana ndi kugwiritsa ntchito mankhwalawa ndikuwonetsedwa m'mayesero azachipatala amalembedwa ndi magulu a ziwalo zamankhwala komanso kuchepa kwa zochitika: zofala kwambiri (> 1/10), zofala (> 1/100, 1 / 1.000, 1/10000 ,

Bongo

Mankhwala osokoneza bongo kwambiri amatha kuyambitsa matenda oopsa ndipo nthawi zina amatha kukhala oopsa kwa hypoglycemia.

Ngati wodwalayo akudziwa, ayenera kudya glucose yomweyo, ndikutsatira zakudya zomwe zimakhala ndi chakudya (onani malangizo apadera ndi njira zopewera kugwiritsa ntchito). Ngati wodwalayo ali ndi vuto losazindikira, ndikofunikira kuyambitsa glucagon mu / m kapena s / c kapena njira yokhazikika ya shuga mkati / mu. Ngati ndi kotheka, kukonzanso kwa shuga pamwambapa ndi kotheka. Mwa ana, kuchuluka kwa shuga komwe kumayendetsedwa kumayikidwa molingana ndi kulemera kwa thupi la mwana.

Mlandu wa hypoglycemia wowopsa kapena wotalika potsatira jakisoni wa glucagon kapena dextrose, tikulimbikitsidwa kuti kulowetsedwa kuchitike ndi njira yokhazikika ya glucose pofuna kupewa kukonzanso kwa hypoglycemia. Mu ana aang'ono, ndikofunikira kuyang'anitsitsa kuchuluka kwa shuga m'magazi, pokhudzana ndi chitukuko chachikulu cha hyperglycemia.

Pazinthu zina, ndikulimbikitsidwa kuti odwala azigonekedwa m'chipinda cha odwala osamala kwambiri kuti athe kuwunika moyenera komanso kuwunika.

Kuchita ndi mankhwala ena

Kugwiritsa ntchito pamodzi mankhwala angapo kumatha kufooketsa kapena kuwonjezera mphamvu ya hypoglycemic ya Insuman Bazal GT. Chifukwa chake, mukamagwiritsa ntchito insulin, simungatenge mankhwala ena popanda chilolezo chapadera cha dokotala.

Hypoglycemia imatha kuchitika ngati odwala nthawi yomweyo omwe ali ndi insulin amalandira mankhwala opatsirana a antiidiabetes, ma AIn inhibitors, disopyramides, fibrate, fluoxetine, MAO inhibitors, pentoxifylline, propoxyphene, acetylsalicylic acid ndi ma salicylates ena, mankhwala a sulfonamide.

Kuchepetsa mphamvu ya insulin kumatha kuwonedwa limodzi ndi insulin ndi corticotropin, glucocorticosteroids, danazole, diazoxide, diuretics, glucagon, isoniazid, estrogens ndi progestogens (kuphatikiza kulera kwamlomo), zotumphukira za phenothiazine, somatotine salbutamol, terbutaline), mahomoni a chithokomiro, ma proteinase inhibitors ndi ma atypical antipsychotic (mwachitsanzo, olanzapine ndi clozapine).

Odwala nthawi yomweyo amatenga insulin ndi beta-blockers, mchere wa clonidine ndi lifiyamu, wofowoka komanso wowonjezera wa insulin ungawonedwe. Pentamidine imatha kuyambitsa hypoglycemia kenako hyperglycemia.

Kumwa mowa kumatha kuyambitsa hypoglycemia kapena kuchepetsa shuga wambiri m'magazi owopsa. Kuleza Mtima Kwa Odwala Kulandila

insulin yafupika. Mitundu yovomerezeka ya zakumwa ziyenera kutsimikiziridwa ndi dokotala. Zakumwa zoledzeretsa, komanso kumwa kwambiri mankhwala osokoneza bongo, zimatha kukhudza kuchuluka kwa shuga m'magazi. Beta-blockers imawonjezera chiopsezo cha hypoglycemia ndipo, pamodzi ndi othandizira ena achifundo (clonidine, guanethidine, reserpine), amatha kufooketsa kapena kupondereza kwathunthu zizindikiro zoyambirira za adrenergic antiregoric (zizindikiro ndi zotsogola za hypoglycemia).

Zotsatira za pharmacological

Mlingo wa Insuman Bazal GT ndi 100 IU / ml. Pambuyo makonzedwe pansi pa khungu, amayamba kuchita pang'onopang'ono, akukwaniritsa zotsatira za hypoglycemic mu ola limodzi. Kuchepetsa kwambiri kwa shuga kumachitika patatha maola atatu jakisoni atatha, jakisoniyo amatha kwa maola 11 mpaka 20. Makina ochitapo kanthu ali ndi mawonekedwe ake:

• Imakhala ndi anabolic, imalepheretsa njira za catabolic, imachepetsa kuchuluka kwa shuga m'magazi a m'magazi.
• Zimathandizira kusamutsa glucose mu cell ndikupanga mbewu za glycogen kuchokera mu hepatocytes ndi minofu, zimalepheretsa glycogenolysis ndi gluconeogeneis, ndikukula kogwiritsa ntchito chomaliza chomaliza - pyruvate.
• Amachepetsa mayendedwe amtundu wa lipolysis, koma amalimbikitsa kaphatikizidwe ka mafuta m'chiwindi.
• Zimawongolera kayendedwe ka amino acid m'maselo a cell ndikupanga mapuloteni.
• Imathandizira kusunthira potaziyamu kudutsa nembanemba kupita kumaselo.

Zotsatira zonse zachilengedwe za insulin insulin basal GT yotsika glycemia.

Zolemba zogwiritsira ntchito

Odwala omwe ali ndi hypersensitivity a mankhwala a Insuman Bazal GT, omwe palibe mankhwala ena omwe angalekerere bwino, amafunikira kupitiliza chithandizo moyang'aniridwa ndi achipatala ndipo ngati kuli koyenera, imodzimodzi ndi chithandizo chodwala matendawa.

Kutenga kwamphamvu kwa insulin yaumunthu yokhala ndi insulin yoyambira nyama ndikotheka. Ndi chidwi chowonjezeka cha wodwalayo kuti apange insulin yakuchokera kwa nyama, komanso m-cresol, kulekerera kwa mankhwala a Insuman Bazal GT kuyenera kuwunikira kuchipatala pogwiritsa ntchito mayeso a intradermal. Ngati pakuyesedwa kwa insulin ya insulin ya munthu kumadziwika, zotsatira zake, monga Arthus, ndiye kuti chithandizo china chikuyenera kuyang'aniridwa ndi achipatala. Mwa kuchuluka kwakukulu kwa odwala omwe ali ndi hypersensitivity kupita ku insulin ya nyama, ndizovuta kusinthira kwa insulin yaumunthu chifukwa cha mtanda wa immunological wa insulini ya anthu ndi insulin yochokera nyama.

Ndi vuto laimpso, kusowa kwa insulin kumatha kuchepa chifukwa cha kusintha kwa kagayidwe kake. Kuwonongeka pang'onopang'ono kwa ntchito ya impso pakukalamba kumatha kutsitsa kuchepa kwazofunikira za insulin.

Kulephera kwambiri kwa chiwindi, kufunika kwa insulin kumatha kuchepa chifukwa cha kuchepa kwa mphamvu ya gluconeogeneis komanso kusintha kwa kagayidwe ka insulin. Mothandizidwa ndi shuga wopanda vuto kapena chizolowezi chokhala ndi zigawo za hyperglycemic kapena hypoglycemic, musanasinthe mlingo, muyenera kuwunika momwe wodwala amatsatirira njira yachipatala, kuyerekezera malo a jakisoni, njira yolondola ya jekeseni, ndikuganiziranso zina zofunika.

Kusintha kwa Insuman Bazal GT

Kusintha kwa wodwala ku mtundu wina kapena mtundu wa insulin kuyenera kuchitika kokha moyang'aniridwa ndi achipatala. Zosintha muyezo wa mankhwala, mtundu (wopanga), mtundu (wabwinobwino, NPH, tepi, wochita zinthu motalika, ndi zina), chiyambi (chinyama, munthu, analogi ya insulin ya anthu) ndi / kapena njira yoperekera ingayambitse kusintha kwa mlingo wa insulin.

Kufunika kusintha (mwachitsanzo, kuti muchepetse) mankhwalawa amatha kuonekera mukangosintha. Komanso, kufunikira kotereku kumatha kukula pang'onopang'ono milungu ingapo.

Pambuyo pochotsa ku insulin ya nyama kupita ku insulin ya anthu, kuchepetsa kufala kungafunike, makamaka, mwa odwala:

- pomwepo pomwe kuchuluka kwa shuga m'magazi kumakhalidwira kotsika ndikuyembekezeka kwa hypoglycemia,

- omwe m'mbuyomu amafunika Mlingo wambiri wa insulin chifukwa cha kupezeka kwa ma insulin antibodies. Kuwunikira mosamala kagayidwe kazinthu pakusintha kuchokera ku mankhwala kupita ku lina ndipo mu masabata oyamba izi zitalimbikitsidwa. Odwala omwe amafuna kwambiri Mlingo wa insulin chifukwa cha kupezeka kwa ma insulin antibodies angafunike kuyang'aniridwa kuchipatala kapena makonzedwe ofanana.

Hypoglycemia imatha kukhazikika ngati kuchuluka kwa insulini kudutsa kofunikira kwambiri.

Pali zisonyezo zina zamankhwala ndizizindikiro zomwe zimayenera kuwonetsa kwa wodwalayo kapena ena za kutsika kwakuthwa m'magazi a shuga. Izi ndi monga: thukuta la mwadzidzidzi, kuluma, kugwedezeka, kugona, kugona, kusokonezeka kwa tulo, mantha, kukhumudwa, kusayenda bwino, nkhawa, nkhawa paresthesia mkamwa komanso kuzungulira pakamwa, kutsekemera, kupweteka mutu, kusayenda bwino kwa kayendedwe, komanso kusakhalitsa. kusokonezeka kwa mitsempha (kufooka kwa mawu ndi masomphenya, zizindikiro za paralo) ndi zomveka zachilendo. Ndi kutsika kwakukula m'magulu a shuga, wodwalayo amatha kulephera kudziletsa ngakhalenso kuzindikira. Zikatero, kuzizira ndi chinyezi pakhungu kumatha kuonedwa, ndipo kupweteka kumawonekeranso.

Odwala ambiri, chifukwa cha mayendedwe a adrenergic, amatha kukhala ndi zotsatirazi, zomwe zikuwonetsa kuchepa kwa kuchuluka kwa shuga m'magazi: thukuta, chinyezi cha khungu, nkhawa, tachycardia (palpitations), kuthamanga kwa magazi, kunjenjemera, kupweteka pachifuwa, kusokonezeka kwa mtima. Chifukwa chake, wodwala aliyense yemwe ali ndi matenda ashuga komanso kulandira insulin ayenera kuphunzira kuzindikira zizindikiro zosadziwika zomwe ndi chizindikiro cha kukhala ndi hypoglycemia. Odwala omwe amayang'anitsitsa shuga m'magazi samakhala ndi hypoglycemia. Kukonda kwambiri hypoglycemia kumatha kulepheretsa wodwala kuyendetsa galimoto komanso kugwiritsa ntchito makina aliwonse. Wodwala mwiniyo amatha kukonza kuchepa kwa shuga komwe adazindikira mwa kudya shuga kapena zakudya zamagulu ochulukirapo. Pazifukwa izi, wodwalayo ayenera kukhala ndi 20 g shuga nthawi zonse. Mokulira kwambiri kwa hypoglycemia, jakisoni wokhazikika wa glucagon akuwonetsedwa (omwe angathe kuchitidwa ndi dokotala kapena antchito oyamwitsa). Pambuyo pakusintha kokwanira, wodwalayo ayenera kudya. Ngati hypoglycemia singathetsedwe mwachangu, ndiye kuti dokotala akuyenera kuyitanidwa mwachangu.Ndikofunikira kudziwitsa dokotala mwachangu za kukula kwa hypoglycemia kuti apange chisankho pakufunika kusintha kwa insulin.

Gulu lowopsa lomwe limakhala ndi odwala omwe ali ndi ziwalo za hypoglycemia ndi kuchepa kwakukulu kwa ziwalo za ziwalo za ziwalo za ziwalo zake za ziwalo zakezi (ziwalo za ziwalo za ziwalo zina).

Chiwopsezo cha kukhala ndi hypoglycemia ndi chachikulu pamayambiriro a chithandizo cha insulin, mukasinthira kukonzekera kwina kwa insulin, mwa odwala omwe ali ndi shuga ochepa m'magazi.

Nthawi zina, zizindikiro za hypoglycemia zimatha kukhala zofowoka kapena kusapezeka. Izi zimachitika m'magulu otsatirawa a odwala:

- odwala omwe adatha kukonza kwambiri kuwongolera kwa shuga,

- odwala omwe hypoglycemia imayamba pang'onopang'ono,

- odwala omwe ali ndi matenda a shuga,

- pamaso pa zotupa zamanjenje (neuropathy),

- wodwala matenda amisala

- ndi chithandizo chothandizirana ndi mankhwala ena (onani

Mogwirizana ndi mankhwala ena)

- posintha insulin.

Zikatero, hypoglycemia imatha kukhala woipa kwambiri (kutayika kwa chikumbumtima) ngakhale wodwalayo asanadziwe kuti ali ndi hypoglycemia.

Zotsatira zotsatirazi ndizotheka kuchepa kwambiri kwa shuga m'magazi: kuchuluka kwa insulin, jakisoni wosayenera wa odwala (odwala okalamba), kusinthana ndi mtundu wina wa insulin, kudumpha chakudya, kusanza, kutsekula m'mimba, kuchita masewera olimbitsa thupi, kuchepetsa mavuto, kumwa mowa, ndi matenda omwe amachepetsa kufunika mu insulin (chiwindi chachikulu kapena matenda a impso, kuchepa kwa ntchito ya adrenal cortex, pituitary kapena chithokomiro), kusintha kwa jekeseni (mwachitsanzo, khungu la pamimba, phewa kapena ntchafu), komanso mogwirizana ndi mankhwala ena mankhwala a venous (onani Kuyanjana ndi mankhwala ena).

Kulephera kutsatira zakudya, kudumpha jakisoni wa insulin, kuchuluka kwa insulin chifukwa cha matenda opatsirana kapena matenda ena, komanso kuchepa kwa zochitika zolimbitsa thupi kungayambitse kuchuluka kwa shuga m'magazi (hyperglycemia), mwina ndi kuchuluka kwa matupi a ketone m'magazi (ketoacidosis). Ketoacidosis imatha kumatha maola ochepa kapena masiku. Pazizindikiro zoyambirira za metabolic acidosis (ludzu, kukodza pafupipafupi, kulephera kudya, kutopa, khungu lowuma, kupuma kwambiri komanso kuthamanga, chidwi cha acetone ndi glucose mkodzo), chithandizo chamankhwala chofunikira ndichofunikira.

Posintha dokotala (mwachitsanzo, nthawi yakuchipatala chifukwa cha ngozi, matenda., Patchuthi), wodwalayo ayenera kudziwitsa dokotala kuti ali ndi matenda ashuga.

Pankhani yokukula kwa matenda a concomitant, kuyang'ana mozama kumafunika. kagayidwe. Nthawi zambiri, kuyesa kwa mkodzo kwa ma ketones kungafunike, ndipo nthawi zambiri ndikofunikira kusintha kwa insulin. Kufunika kwa insulin nthawi zambiri kumachuluka. Pa matenda a shuga a Type 1, odwala ayenera kupitiliza kudya zakudya zamafuta pang'ono, pang'ono pang'ono, ngakhale atatha kudya pang'ono kapena asakudya, kapena atasanza ndi zina zotere, sayenera kuphonya jakisoni wambiri wa insulin.

Zolakwa zamankhwala zidanenedwa pamene mitundu ina ya Kutulutsidwa kwa Insuman, kapena insulin ina, idaperekedwa mwangozi m'malo mwa Insuman. Zolemba za insulini ziyenera kuyang'aniridwa nthawi iliyonse jekeseni isanachitike kuti mupewe cholakwika pakati pa insulin glargine ndi insulin zina.

Kuphatikiza kwa Insuman ndi pioglitazone

Milandu yakulephera kwa mtima idanenedwa pomwe pioglitazone imagwiritsidwa ntchito limodzi ndi insulin, makamaka kwa odwala omwe ali ndi chiopsezo cha mtima. Izi zikuyenera kukumbukiridwa popereka kaphatikizidwe ka pioglitazone ndi Insuman. Mukamwa mankhwala osakanikirana, ndikofunikira kuyang'anira odwala molingana ndi mawonekedwe a zizindikiro ndi zizindikiro za kulephera kwa mtima, kuchuluka kwa thupi ndi edema.

Pioglitazone iyenera kusiyidwa ngati vuto lina lililonse la kufooka kwa mtima likupezeka.

Kukopa pa kuyendetsa galimoto ndi njira zogwirira ntchito

Kuchita kwa wodwalayo chidwi komanso kuyankha kumatha kuchepa chifukwa cha hypoglycemia kapena hyperglycemia, kapena, mwachitsanzo, chifukwa cha kuwonongeka kwa mawonekedwe. Izi ndizowopsa nthawi yomwe maluso omwe ali pamwambawa ali ofunikira makamaka (mwachitsanzo, poyendetsa kapena makina ogwira ntchito).

Odwala akuyenera kuchenjezedwa pakufunika kwa kusamala popewa kukula kwa hypoglycemia mukamayendetsa. Izi ndizofunikira kwambiri kwa iwo omwe ali ndi zizindikiro zakutsogolo kwa hypoglycemia omwe ali ofatsa kapena osakhalapo, kapena zochitika za hypoglycemia zimachitika pafupipafupi. Funso liyenera kudzutsidwa panzeru ya kuyendetsa galimoto ndi kuwongolera magwiridwe antchito m'malo oterowo

Kutulutsa Fomu

Kuyimitsidwa 100 IU / ml - 5 ml ya mankhwalawa pakhungu lowonekera1gb ^ kapu yamauni. Botolo limapangidwa m'maso, limafinya ndi chipewa cha aluminium ndikutchinga ndi kapu ya pulasitiki yoteteza. Pa mabotolo 5 limodzi ndi malangizo ogwiritsira ntchito pakatoni. Kuyimitsidwa 100 IU / ml - 3 ml ya mankhwalawa katiriji kamaso oyera ndi opanda khungu. Katirijiyo amakhazikika mbali imodzi ndi nkhata ndipo imamizidwa ndi kapu ya aluminiyamu, mbali inayo - ndi phula. Kuphatikiza apo, mipira itatu yachitsulo imayikidwa katiriji. Makatoni 5 ndi malangizo ogwiritsira ntchito pabokosi lamakalata.

Malo osungira

Sungani pamtunda wa 2 ° C - 8 ° C m'malo amdima.

Osamawuma! Musalole kuti chidebe chilumikizane mwachindunji ndi mafayilo kapena zinthu zachisanu.

Mukatha kugwiritsa ntchito, sungani kutentha osapitirira 25 ° C pabokosi lamakatoni (koma osati mufiriji).

Pewani patali ndi ana!

Mankhwala

The yogwira mankhwala Insuman Bazal GT - insulin-isophan imapezeka ndi ma genetic engineering ogwiritsira ntchito E. coli K12 135 pINT90d, mu kapangidwe kake kamafanana ndi insulin yaumunthu.

Mankhwala amachepetsa shuga m'magazi, amachepetsa zotsatira za catabolic ndikulimbikitsa kukula kwa anabolic. Imawonjezera kuyendetsa kwa glucose ndi potaziyamu m'maselo, kumawonjezera kaphatikizidwe ka glycogen m'chiwindi ndi minofu, kumalepheretsa gluconeogeneis ndi glycogenolysis, kumapangitsa kuyenda kwa ma amino acid m'maselo, kaphatikizidwe ka mapuloteni komanso kugwiritsa ntchito kwa pyruvate. Isulin insulin imachepetsa lipolysis, imawonjezera lipogenesis mu chiwindi ndi adipose minofu.

Mphamvu ya hypoglycemic imayamba mkati mwa ola limodzi, imafika pazowonjezera pambuyo pa maola 3-4, imapitirira kwa maola 11 mpaka 20.

Insuman Bazal GT, malangizo ogwiritsira ntchito: njira ndi mlingo

Dokotalayo amawona mtundu wa insulini (kuchuluka ndi nthawi ya makonzedwe) payekhapayekha kwa wodwala aliyense, ngati pakufunika kutero, amasintha mogwirizana ndi momwe wodwalayo alili, kuchuluka kwa zochita zake zolimbitsa thupi ndi zakudya.

Palibe malamulo oyendetsedwa ndi insulin dosing. Pafupifupi tsiku lililonse ndi 0.5-1 IU / kg, pomwe gawo la insulin yotalika kwa munthu ndi 40-60% ya okwanira tsiku ndi tsiku a insulin.

Dokotala wophunzirayo ayenera kuphunzitsa wodwalayo pafupipafupi kuti azindikire kuchuluka kwa shuga m'magazi, komanso apatseni malangizo okhudza momwe mankhwalawo angapangire insulin.

Insuman Bazal GT nthawi zambiri imayendetsedwa mozama s / c 45-60 mphindi musanadye.Jekeseni aliyense, tsamba la jekeseni liyenera kusinthidwa mu gawo lomwelo la makonzedwe. Kusintha malowa (mwachitsanzo, kuyambira pamimba mpaka pa ntchafu) kuyenera kuchitika pokhapokha kukaonana ndi dokotala, chifukwa chitha kusintha mayendedwe a insulini ndipo, chifukwa chake, kusintha kwazomwe zimachitika.

Insuman Bazal GT sayenera kugwiritsidwa ntchito pamapampu osiyanasiyana a insulin, kuphatikiza mapampu obayira. Mothandizidwa ndi mtsempha wa magazi amaletsedwa kotheratu! Simungasakanikize ndi ma insulin a ndende ina, insulin analogues, insulini yoyambira nyama ndi mankhwala ena aliwonse.

Insuman Bazal GT imaloledwa kusakanikirana ndi insulin yonse yokonzekera yopangidwa ndi Sanofi-Aventis Gulu.

Ndende ya insulini pokonzekera ndi 100 IU / ml, motero, momwe mungagwiritsire ntchito Mbale 5 ml, ma syringe okha a pulasitiki omwe ali ndi izi ayenera kugwiritsidwa ntchito, ngati mugwiritse ntchito makatiriji atatu a 3 ml, systinges kapena ma pensulo a OptiPen Pro1.

Nthawi yomweyo asanaimbe, kuyimitsidwa kwake kuyenera kusakanikirana bwino ndikuyang'aniridwa. Kukonzekera kukonzekera kuyenera kukhala kwamayanjidwe oyera amiyala yoyera. Ngati kuyimitsidwa kuli ndi mawonekedwe osiyana (kumakhalabe kowonekera, mabampu kapena ma flakes apanga madzi kapena pamakoma / pansi pa vial), simungathe kugwiritsa ntchito.

Kusintha kwa Insuman Bazal GT kuchokera ku mtundu wina wa insulin

Pakusintha mtundu wina wa insulin ndi ina, nthawi zambiri pamafunika kusintha mtundu wa mankhwalawo, mwachitsanzo, m'malo mwa insulin yochokera ku nyama ndi munthu, kusintha kuchokera ku insulin yaumunthu kupita ku imzake, kusamutsa wodwala kuti akhale ndi insulin ya insulle yamunthu.

Pankhani ya kulowetsedwa kwa insulin ya nyama ndi insulin ya anthu, pangafunikire kuchepetsa kuchuluka kwa Insuman Bazal GT, makamaka kwa odwala omwe amathandizidwa m'magazi a shuga m'magazi, omwe ali ndi chizolowezi chokhala ndi hypoglycemia, yomwe kale idafunikira insulin yayikulu chifukwa cha kukhalapo kwa ma antibodies ake .

Kuchepetsa mlingo kungafunike mukangosamutsira wodwala ku mtundu wina wa insulin. Komanso kufunika kwa insulin kumatha kuchepa pang'onopang'ono milungu ingapo.

Pakusintha kwa Insuman Bazal GT ndi mtundu wina wa insulin komanso m'milungu yoyamba yamankhwala, ndikofunikira kuyang'anitsitsa kuchuluka kwa shuga m'magazi. Odwala omwe, chifukwa cha kupezeka kwa ma antibodies, amafunikira kwambiri Mlingo wa insulin, tikulimbikitsidwa kusinthidwa kupita kuchipatala moyang'aniridwa ndi achipatala.

Ndi bwino kagayidwe kachakudya, kuwonjezeka kwa insulin sensitivity ndikotheka, chifukwa chomwe kufunika kwa thupi kumachepa.

Kusintha kwa mlingo wa Insuman Bazal GT kungakhale kofunikira ngati wodwalayo wasintha moyo wake (mulingo wakuchita zolimbitsa thupi, kudya, ndi zina), kulemera kwa thupi ndi / kapena zochitika zina, chifukwa cha zomwe zikuwonjezera kulosera kwatsoka la hyper- kapena hypoglycemia.

Kufunika kwa insulini kumatha kuchepa kwa odwala omwe ali ndi vuto laimpso / chiwindi, mwa okalamba. Pankhaniyi, kusankha kwa Mlingo woyambirira ndikukonzanso kuyenera kuchitika mosamala kwambiri (pofuna kupewa chitukuko cha hypoglycemic).

1. Chotsani kapu ya pulasitiki m'botolo.
2. Sakanizani kuyimitsidwa bwino: tengani vial pamtunda wapakati pakati pa manja anu ndikuchepetsa (popewa kufumbwa) mutembenuzire.
3. Sungani mpweya mu syringe mu voliyumu yolingana ndi kuchuluka kwa insulini, ndikuyiyika mu vial (osayimitsidwa).
4. Popanda kuchotsa syringe, tembenuzani botolo pansi ndikujambulani mankhwalawo.
5. Chotsani thovu zam'mlengalenga mu syringe.
6. Sonkhanitsani khola ndi zala ziwiri, ikani singano m'munsi mwake ndikulowetsa insulini pang'onopang'ono.
7. Pang'onopang'ono, chotsani singano ndikufinya jakisoniyo ndi swab ya thonje kwa masekondi angapo.
8. Lembani tsiku la cholembera choyamba pa cholembera.

Cartridges adapangidwa kuti azigwiritsidwa ntchito ndi zolembera za systinge ya ClickStAR ndi OptiPen Pro1. Asanaikidwe, cartridge iyenera kusungidwa kutentha kwa maola 1-2, popeza kuti jakisoni wa insulin yozizira ndi wowawa. Kenako muyenera kusakaniza kuyimitsidwa kukhala dziko lokhala ndi vuto: pang'onopang'ono mutembenuzire cartridge pafupifupi nthawi 10 (katiriji iliyonse imakhala ndi mipira itatu yachitsulo yomwe imakulolani kusakaniza mwachangu zomwe zili).

Ngati katiriji waikapo kale cholembera, mutembenuzire pamodzi ndi cartridge. Njirayi iyenera kuchitidwa isanayambike iliyonse ya Insuman Bazal GT.

Cartridges sanapangidwe kuti aphatikize mankhwalawo ndi mitundu ina ya insulin. Zopanda zopanda kanthu siziyenera kudzazidwa. Pakachitika kuphwanya syringe, gawo loyenera kuchokera pa cartridge limatha kutumizidwa pogwiritsa ntchito syrile yonyowa, yongogwiritsa ntchito syringe yokha yapulasitiki yomwe idapangidwira insulin iyi.

Mukayika makatoni atsopano musanalowetse muyeso woyamba, muyenera kuyang'ana kuyenera kwa cholembera.

Kugwiritsa ntchito Insuman Bazal GT mu zolembera za SoloStar

Asanagwiritse ntchito koyamba, cholembera cha syringe chimasungidwa kutentha kotheratu kwa maola 1-2. Mukamagwiritsa ntchito, cholembera cha syringe chimatha kusungidwa kutentha kwambiri (mpaka 25 ° C), komabe, ngati chimasungidwa mufiriji, chimayenera kuchotsedwa nthawi zonse maola 1-2 jekeseni isanachitike.

Pamaso pa jekeseni iliyonse, muyenera kusakaniza kuyimitsidwa kuti ikhale yolimba: kugwirizira cholembera pakati pachimake, ndikuzunguliza molunjika kuzungulira mbali yake.

Ntchito zolembera za SoloStar zomwe zikugwiritsidwa ntchito ziyenera kutayidwa popeza sizipangidwire kuti ziphwanyidwe. Popewa kutenga matenda, wodwala m'modzi yekha ndiye ayenera kugwiritsa ntchito cholembera chilichonse.

Pamaso jakisoni woyamba, tikulimbikitsidwa kuti muwerenge malangizo ogwiritsira ntchito cholembera cha SoloStar - imakhala ndi chidziwitso cha kukonzekera koyenera, kusankha kwa mankhwalawa komanso utsogoleri wa mankhwala.

Malamulo ofunikira pakugwiritsira ntchito SoloStar Syringe pen:

• gwiritsani singano zokha zogwirizana ndi SoloStar,
• gwiritsani ntchito singano yatsopano pa jekeseni iliyonse ndikuchita mayeso a chitetezo nthawi iliyonse,
• samalani ndikofunika kupewa kuti ngozi zokhudzana ndi kugwiritsa ntchito singano ndizotheka kufalitsa matenda,
• osagwiritsa ntchito cholembera chomwe chili ndi zowonongeka kapena njira ya dosing ya mankhwala osokoneza,
• Tetezani cholembera ku dothi ndi fumbi (kuchokera kunja limatha kupukutidwa ndi nsalu yoyera, yonyowa, koma simungathe kusamba, kuyitsanso ndi kumiza m'madzi chifukwa chitha kuwonongeka),
• Nthawi zonse tengani cholembera chopanda chilichonse ngati chawonongeka kapena chitayika chachikulu.

Kugwiritsa ntchito cholembera SoloStar:

Zotsatira zoyipa (zotchulidwa motere: nthawi zambiri - ≥ 1/10, nthawi zambiri - kuchokera ≥ 1/100 mpaka

Mphamvu yogwira: 1 ml ya kuyimitsidwa imakhala ndi 100 ME (3.571 g) ya insulin yaumunthu. Omwe amathandizira: protamine sulfate, m-cresol, phenol, zinc chloride, sodium dihydrogen phosphate dihydrate (E339), glycerol 85% (E422), sodium hydroxide (E524), madzi owonjezera a hydrochloric acid (E507), madzi a jakisoni.

Insuman Bazal GT ilinso ndi insulin yofanana ndi insulin yaumunthu ndipo yopezeka ndi ma genetic engineering ogwiritsa ntchito K12 kufinya E. Coli.

- Amachepetsa glucose wamagazi ndikuwonjezera zotsatira za anabolic, komanso amachepetsa zotsatira za catabolic,

- imathandizira kayendedwe ka glucose m'maselo, komanso mapangidwe a glycogen mu minofu ndi chiwindi, zimathandizira kugwiritsa ntchito pyruvate. Imalepheretsa glycogenolysis ndi glyconeogeneis,

- amalimbitsa lipogenesis mu chiwindi ndi adipose minofu ndi ziletsa lipolysis,

- imalimbikitsa kumwa ma amino acid ndi maselo ndikuwonjezera kuphatikiza mapuloteni,

- Imalimbikitsa kumwa potaziyamu ndi maselo.

Insuman Bazal GT (kuyimitsidwa kwa isofan-insulin) ndi insulin yokhala pang'onopang'ono ndikupanga nthawi yayitali. Mphamvu ya hypoglycemic imachitika mkati mwa ola limodzi, ndipo imafikira pakapita maola atatu pambuyo poti mankhwalawa ayende. Zotsatira zimapitirira kwa maola 11 mpaka 20.

Hafu ya moyo wa seramu insulini m'maphunziro athanzi ndi pafupifupi maminiti 4-6. Kulephera kwambiri kwa impso, kumatenga nthawi. Tiyenera kudziwa kuti pharmacokinetics ya insulin sikuwonetsa metabolic yake.

Zotsatira Zoyesera Za chitetezo

Kafukufuku wokhudzana ndi kawopsedwe wazovuta adachitika pambuyo poyendetsa makina mpaka makoswe. Palibe zoyipa zomwe zapezeka. Kafukufuku wokhudzana ndi pharmacodynamic zotsatira za subcutaneous kayendetsedwe ka mankhwala kwa akalulu ndi agalu adavumbulutsa zomwe zimayembekezereka zimachitika.

Matenda a shuga odwala matenda a insulin.

Hypersensitivity to the yogwira ntchito kapena aliyense wa iwo opeza.

Insuman Bazal GT silingathe kutumikiridwa kudzera m'mitsempha kapena potulutsa insulin kapena pampu ya insulin yakunja.

Palibe maphunziro azachipatala omwe amagwiritsidwa ntchito popanga insulin yaumunthu panthawi yapakati. Insulin siyidutsa chotchinga. Popereka mankhwala kwa amayi apakati, muyenera kusamala.

Pankhani ya odwala preexisting kapena gestationalabetes mellitus, ndikofunikira kusungabe kuchuluka koyenera kwa metabolic panthawi yonse yokhala ndi pakati. Kufunika kwa insulini mu nthawi yoyambirira ya kubereka kumatha kuchepa, koma m'nthawi yachiwiri ndi yachitatu matupi awo amakula. Pambuyo pobadwa, insulin imafunikira imatsika mofulumira (chiwopsezo chowonjezereka cha hypoglycemia). Kuwunikira mosamala kuchuluka kwa shuga m'magazi kumafunika.

Panthawi yoyamwitsa, palibe malamulo oletsa insulin. Komabe, mlingo wa insulin komanso kusintha kwa zakudya kungafunike.

Kusankhidwa kwa shuga wamagazi ofunikira, kukonzekera kwa insulini ndi mlingo wake kwa wodwalayo kumachitika ndi dokotala kutengera zakudya, mulingo wakuchita zolimbitsa thupi ndi moyo. Mlingo wa insulin umatsimikizika potengera kuchuluka kwa shuga m'magazi, komanso pamaziko a kuchuluka kwa zochitika zolimbitsa thupi komanso mkhalidwe wa metabolism ya carbohydrate. Chithandizo cha insulin chimafuna kudziphunzitsa koyenera kwa wodwala. Dokotala amayenera kupereka malangizo ofunikira kangati kuti azindikire kuchuluka kwa shuga m'magazi, komanso apereke malangizo oyenera ngati kusintha kulikonse pakudya kapena muyezo wa insulin.

Mlingo watsiku ndi tsiku ndi nthawi yoyendetsera

Mwachizolowezi, avareji ya tsiku ndi tsiku ya insulin imachokera ku 0,5 mpaka 1.0 ME pa kilogalamu imodzi ya kulemera kwa odwala, pomwe 40-60% ya mlingo wokhala insulin ya anthu. Insuman Bazal GT imakonda kutumikiridwa kwambiri mphindi 45-60 asanadye.

Pambuyo kusintha kusintha

Kuwongolera kuwongolera kwa glycemic kungayambitse kuchuluka kwa insulin, zomwe zingayambitse kuchepa kwa insulin. Kuphatikiza apo, kusintha kwa mlingo kungafunikenso, mwachitsanzo, pakusintha kulemera kwamthupi la wodwalayo,

- posintha moyo wa wodwalayo (kuphatikizapo zakudya, kuchuluka kwa zochitika zolimbitsa thupi, ndi zina),

- munthawi zina zomwe zimawonjezera chizolowezi chopanga hypoglycemia kapena hyperglycemia (onani malangizo apadera ndi njira zopewera kugwiritsa ntchito).

Ntchito mu magulu apadera amawu

Odwala okalamba ndi odwala omwe ali ndi vuto la impso ndi kwa chiwindi, kufunafuna kwa insulin kungachepe.

Insuman Bazal GT imayendetsedwa mosakakamiza. Mothandizidwa ndi mtsempha wa mankhwalawa samachotsedwa konse!

Kuyamwa kwa insulin ndipo, chifukwa chake, kuchuluka kwa glucose komwe kumapangitsa kuti mankhwalawo athandizidwe kumatha kusiyanasiyana potengera jakisoni (mwachitsanzo, dera la khoma lachiberekero lakumbuyo poyerekeza ndi dera la akazi).Ndi jakisoni aliyense wotsatira, tsamba la jakisidwe liyenera kusinthidwa mkati momwe.

Tsamba la jakisoni liyenera kusinthidwa nthawi iliyonse. Kusintha kwa jekeseni (mwachitsanzo, kuyambira pamimba mpaka ntchafu) kuyenera kuchitika pokhapokha mukaonana ndi dokotala.

Insuman Bazal GT sagwiritsidwa ntchito mitundu yosiyanasiyana ya mapampu a insulini (kuphatikizapo omwe adalowetsedwa).

Musasakanize Insuman Bazal GT ndi insulin ya ndende ina (mwachitsanzo, 40 IU / ml ndi 100 IU / ml), ndi insulin yakuchokera kwa nyama kapena mankhwala ena.

Kumbukirani kuti insulin ndende ya 100 IU / ml (ya ma ml 5 kapena ma 3 ml cartridge), motero, ndikofunikira kugwiritsa ntchito syringes zapulasitiki zokha zomwe zimapangidwira insulin iyi pokhapokha ngati mugwiritsa ntchito mbale, kapena cholembera cha syringe cha OptiPen Pro1. Syringe ya pulasitiki siyenera kukhala ndi mankhwala ena aliwonse kapena zotsalira zake.

Pamaso gawo loyambirira la insulin kuchokera pambale, chotsani pulasitiki (kukhalapo kwa kapuyo ndi umboni wa vial wosatsutsana). Kuyimitsidwa kuyenera kusakanizidwa bwino nthawi isanakhazikitsidwe, ndipo palibe chithovu chomwe chingapangidwe. Izi zimachitika bwino ndikutembenuza botolo, ndikuligwirizira kumbali yayikulu pakati pa manja. Pambuyo posakanikirana, kuyimitsidwa kumayenera kukhala kosasinthasintha komanso mtundu wamiyala yoyera. Kuyimitsidwa sikungagwiritsidwe ntchito ngati kuli ndi mtundu wina, i.e. ngati ikhala yowonekera bwino kapena masamba kapena mapanga apanga madziwo, pansi kapena kukhoma kwa vial. Zikatero, muyenera kugwiritsa ntchito botolo lina lomwe likugwirizana ndi zomwe zili pamwambapa, ndipo muyenera kudziwitsa dokotala.

Asanatenge insulini kuchokera ku vial, mpweya wofanana ndi mankhwala omwe amaperekedwa ndi insulin umayamwa mu syringe ndikujowina mu vial (osalowa madzi). Kenako vala yokhala ndi syringe imasinthidwa mozungulira ndi syringe ndipo kuchuluka kwa insulini kumatengedwa. Pamaso jakisoni, chotsani thovu lakumanzere mu syringe.

Khungu limatengedwa pamalo a jakisoni, singano imayikidwa pansi pakhungu, ndipo insulin imayamwa pang'onopang'ono. Pambuyo pa jekeseni, singano imachotsedwa pang'onopang'ono ndipo tsamba lamalowo limakanikizidwa ndi swab ya thonje kwa masekondi angapo. Tsiku lokhala ndi insulin kit kuchokera pa vial iyenera kulembedwa pa cholembera cha vial.

Pambuyo pakutsegulira, mabotolo amatha kusungidwa kutentha osaposa +25 ° C kwa milungu 4 m'malo otetezedwa ku kuwala ndi kutentha.

Musanayikitse cartridge (100 IU / ml) mu cholembera cha sytiit ya OptiPen Pro1, siyani iyo iyime kwa maola 1-2 kutentha kwa chipinda. Pambuyo pake, ndikutembenuza mokoma cartridge (mpaka nthawi 10) kuti mupeze kuyimitsidwa kwapadera. Kathumba kalikonse kophatikizira kamakhala ndi mipira itatu yachitsulo posakaniza mwachangu zomwe zili mkati mwake. Mukayika katoni mu syringe cholembera, ndikulowetsani cholembera kambirimbiri pamaso panu jakisoni wa insulin kuti mupeze kuyimitsidwa kwapadera. Pambuyo posakanikirana, kuyimitsidwa kumayenera kukhala kosasinthasintha komanso mtundu wamiyala yoyera. Kuyimitsidwa sikungagwiritsidwe ntchito ngati kuli ndi mtundu wina, i.e. ngati ikhala yowonekera bwino kapena masamba kapena mapampu apanga madziwo, pansi kapena pansi pa makatoni. Zikatero, muyenera kugwiritsa ntchito cartridge ina yomwe ikukwanira pamwambapa, ndipo muyenera kudziwitsa dokotala. Chotsani zotumphukira zilizonse zamagetsi pamkatikati musanabayidwe (onani Malangizo Ogwiritsa Ntchito OptiPen Pro1 Syringe pen).

Katoniyo sanapangire kusakaniza Insuman Bazal GT ndi ma insulini ena. Makatoni opanda kanthu sangakwaniritsidwe.

Pakuswa phala la syringe, mutha kulowa muyezo wofunika kuchokera pa cartridge pogwiritsa ntchito syringe yachizolowezi. Kumbukirani kuti kuchuluka kwa insulini mu cartridge ndi 100 IU / ml, kotero muyenera kugwiritsa ntchito syringes zapulasitiki zomwe zimapangidwira insulin iyi.Syringe siyenera kukhala ndi mankhwala ena aliwonse kapena zotsalira zake.

Pambuyo kukhazikitsa cartridge, itha kugwiritsidwa ntchito - ® kwa> milungu 4. Ndikulimbikitsidwa kusungidwa pa kutentha osapitirira 25 ° C pamalo otetezedwa ku kuwala ndi kutentha. Mukamagwiritsa ntchito cartridge, cholembera sichingasungidwe mufiriji.

Mukakhazikitsa cartridge yatsopano, yang'anani ntchito yoyenera ya cholembera musanalowe jekeseni yoyamba (onani Malangizo ogwiritsira ntchito cholembera cha OptiPen Pro1).

Hypoglycemia, njira yodziwika bwino kwambiri, imatha kupezeka ngati mlingo wa insulin woperekedwa umapitilira kufunikira kwake. Sizingatheke kufotokoza kuchuluka kwa vuto la hypoglycemia, chifukwa kufunika kwa mayesero azachipatala komanso kugwiritsa ntchito mankhwala ogulitsa kumatha kusiyanasiyana malinga ndi kuchuluka kwa anthu komanso kuchuluka kwake. Zochitika zowopsa za hypoglycemia, makamaka ngati zibwerezedwa, zimatha kuyambitsa kukulitsa kwa mitsempha, kuphatikizapo kukomoka, kukokana. Nthawi zina, zochitika ngati izi zitha kupha.

Odwala ambiri, zizindikiro za kuwonongeka kwa hypoglycemic kwa chapakati mantha amayamba ndi zizindikiro za kutsutsana ndi adrenergic. Monga lamulo, momwe kuchuluka kwa glucose m'magazi kumachepera, ndiye kuti tanthauzo la kutsutsana ndi zomwe zimachitika.

Zotsatira zotsatirazi zotsutsana ndi kugwiritsa ntchito mankhwalawa ndikuwonetsedwa m'mayesero azachipatala amalembedwa ndi magulu a ziwalo zamankhwala komanso kuchepa kwa zochitika: zofala kwambiri (> 1/10), zofala (> 1/100, 1 / 1.000, 1/10000 ,

1. 
   Boris, Moroz und Elena Khromova Opaleshoni yamafupa pantchito yamano kwa odwala omwe ali ndi matenda osokoneza bongo / Boris Moroz und Elena Khromova. - M: LAP Lambert Academic Publishing, 2012 .-- 140 p.
2. 
   Dreval, A.V. Kupewa kwamachulukidwe amakono a shuga mellitus / A.V. Zopanda, I.V. Misnikova, Yu.A. Kovaleva. - M: GEOTAR-Media, 2013 .-- 716 p.
3. 
   Evsyukova I.I., Kosheleva N.G. Matenda a shuga. Mimba komanso akhanda, Miklos -, 2009. - 272 c.
4. Chakudya chomwe chimachiritsa matenda ashuga. - M: Club yazosangalatsa za mabanja, 2011. - 608 c.
5. Zakharov Yu.L. Mankhwala aku India. Maphikidwe agolide. Moscow, Pressverk Publishing House, masamba 2001,475, makope 5,000

Ndiloleni ndidziwitse. Dzina langa ndi Elena. Ndakhala ndikugwira ntchito ya endocrinologist kwa zaka zoposa 10. Ndikukhulupirira kuti pakadali pano ndili katswiri pantchito yanga ndipo ndikufuna kuthandiza alendo onse omwe amapezeka pamalowo kuti athetse zovuta osati ntchito. Zinthu zonse za tsambalo amazisonkhanitsa ndikuzikonza mosamala kuti athe kufotokoza zambiri zofunikira. Musanagwiritse ntchito zomwe zikufotokozedwa pa webusaitiyi, kufunsana ndi akatswiri ndizofunikira nthawi zonse.

Zotsatira zoyipa

Hypoglycemia, zotsatira zoyipa kwambiri, zimatha kukhala ngati mlingo wa insulin woperekedwa umaposa kufunikira kwake (onani "Njira zopewera komanso malangizo apadera").
Kusintha kwakukulu mu shuga m'magazi kumatha kubweretsa zosokoneza pang'ono. Komanso, makamaka ndi insulin Therapy, kuwonjezereka kwakanthawi kwamtsogolo kwa matenda ashuga retinopathy ndikotheka. Odwala omwe ali ndi proliferative retinopathy, osagwiritsa ntchito njira ya laser, zovuta kwambiri zam'magazi zingayambitse khungu.
Nthawi zina atrophy kapena hypertrophy ya adipose minofu imatha kuchitika malo a jekeseni, omwe amatha kupewedwa ndikusintha malo a jekeseni nthawi zonse. Nthawi zina, kufupika pang'ono kumatha kupezeka pamalowo jakisoni, ndikusowa ndikupitilira mankhwala. Ngati erythema yofunika ikakhazikitsidwa, limodzi ndi kuyabwa ndi kutupa, ndikufalikira mwachangu mpaka pamalo a jekeseni, komanso zovuta zina zoyipa zomwe zimapezeka ndi mankhwala (insulin, protamine, m-cresol, phenol), muyenera kudziwitsa adotolo, monga momwe zimakhalira nthawi zina, izi zimatha kuwopsa pamoyo wa wodwalayo. Kusintha kwakukulu kwa Hypersensitivity kumachitika kawirikawiri. Amathanso kuphatikizidwa ndi chitukuko cha angioedema, bronchospasm, kugwa kwa magazi komanso kusowa kwa anaphylactic.Hypersensitivity reaction imafunikira kukonza mwachangu pakanthawi kovomerezeka ndi insulin komanso kukhazikitsidwa kwa njira zoyenera zadzidzidzi.
Mwina kupangika kwa ma antibodies ku insulin, komwe kungafune kusintha kwa mlingo wa insulin. Ndiwothekanso kusungidwa kwa sodium komwe kumayamba chifukwa cha kutupa kwa minofu, makamaka mukamaliza kumwa mankhwalawa.
Ndi kuchepa kwambiri m'magazi a shuga m'magazi, ndizotheka kukulitsa hypokalemia (zovuta kuchokera ku mtima) kapena kukula kwa edema ya ubongo.
Popeza zovuta zina zimatha kukhala zowopsa pamoyo, ndikofunikira kudziwitsa adokotala zikafika.
Ngati mukuwona mavuto aliwonse, chonde onani dokotala!

Mimba komanso kuyamwa

Chithandizo cha Insuman ® Basal GT panthawi yoyembekezera ziyenera kupitilizidwa. Insulin siyidutsa chotchinga. Kusunga moyenera kagayidwe kazakudya panthawi yonse yoyembekezera ndikovomerezeka kwa azimayi omwe ali ndi matenda ashuga asanabadwe, kapena amayi omwe apanga matenda a shuga.

Kufunika kwa insulin panthawi yapakati kumatha kuchepa panthawi yayitali ya kubereka ndipo nthawi zambiri kumawonjezeka panthawi yachiwiri komanso yachitatu ya amayi omwe ali ndi pakati. Pambuyo pobadwa, insulini ikucheperachepera (chiwopsezo cha hypoglycemia). Pa nthawi ya pakati komanso makamaka mukabereka mwana, kuwunika mosamala kuchuluka kwa shuga m'magazi kumafunika.

Ngati muli ndi pakati kapena mukufuna kubereka, onetsetsani kuti mwadziwitsa dokotala.

Panthawi yoyamwitsa, palibe zoletsa pazotsatira za insulin, komabe, mlingo wa insulin komanso kusintha kwa zakudya kungafunike.

Zotsatira zoyipa

Hypoglycemia. Zotsatira zoyipa kwambiri za insulin. Magawo obwerezabwereza a hypoglycemia angayambitse kukula kwa zizindikiro zamitsempha, kuphatikizapo chikomokere, onani. Kukhalitsa kwa nthawi yayitali kapena koopsa kwa hypoglycemia kumatha kukhala pachiwopsezo cha moyo.

Odwala ambiri, zizindikiro ndi mawonekedwe a neuroglycopenia atha kukhala patsogolo ndi zizindikiro za Reflex (poyankha kukulitsa hypoglycemia) kutsegulira kwa mtima wamanjenje. Nthawi zambiri, ndi kuchepa kwambiri kapena kuchepa msanga kwa kuchuluka kwa shuga m'magazi, chodabwitsa cha kutseguka kwa mphamvu yamanjenje yomvera chisoni ndikuonetsa zizindikiro zake.

Ndi kuchepa kwakukulu kwa kuchuluka kwa shuga m'magazi, kukulitsa kwa hypokalemia (zovuta kuchokera ku CCC) kapena kukulitsa edema ya ubongo.

Otsatirawa ndi zochitika zoyipa zomwe zimayesedwa m'magulu oyeserera omwe amatsatiridwa ndi magulu opatsirana mwatsatanetsatane komanso kuchepa kwa zochitika: pafupipafupi kwambiri (≥1 / 10), pafupipafupi (≥1 / 100 ndi kuthamanga kwa magazi (kusadziwika pafupipafupi) ndi kugwedezeka kwa anaphylactic (infrequent zochita) ndipo zitha kuyika moyo wa wodwala pathupi. Matupi amtundu wa machitidwe amafuna kuti pakhale njira zoyenera zadzidzidzi. Kugwiritsa ntchito insulin kungapangitse kuti ma antibodies apange insulin (pafupipafupi sichikudziwika). Nthawi zina, kupezeka kwa ma antibodies ku Sulin ingafune kusintha kwa insulin kuti athetse vuto la hyper- kapena hypoglycemia.

Kuchokera kumbali ya kagayidwe ndi zakudya: insulin ingayambitse kusungidwa kwa sodium (pafupipafupi osadziwika) ndi edema (nthawi zambiri), makamaka pakukonzanso njira zoyenera za kagayidwe kogwiritsa ntchito insulin.

Kuchokera kumbali ya gawo la masomphenyawo: Kusintha kwakukulu mu kayendetsedwe ka glycemic kumatha kuyambitsa kusokonezeka kowoneka pang'ono (pafupipafupi kosadziwika) chifukwa chosintha kwakanthawi mu ma toni amaso ndi cholozera wawo.

Kusintha kwa nthawi yayitali mu glycemic control kumachepetsa chiopsezo cha kupitirira kwa matenda ashuga retinopathy. Komabe, mankhwala a insulin ochulukirapo komanso osintha kwambiri pakayang'aniridwe ka glycemic atha kuphatikizidwa ndi kuwonongeka kwakanthawi mkati mwa matenda a shuga a retinopathy (pafupipafupi osadziwika). Odwala omwe ali ndi proliferative retinopathy, makamaka ngati samalandira chithandizo ndi Photocoagulation (laser therapy), zochitika zazikulu za hypoglycemic zingayambitse maurosis osakhalitsa (kutayika kwathunthu kwa masomphenya) (pafupipafupi kusadziwika).

Pa khungu ndi subcutaneous minofu: Monga momwe mungagwiritsire ntchito mankhwala aliwonse a insulini, ndikotheka kukulitsa lipodystrophy pamalo opangira jakisoni (pafupipafupi osadziwika) ndikuchepetsa kuchepa kwa insulin.

Kusintha komwe kumayambira jakisoni m'malo olimbikitsira kungathandize kuchepetsa kapena kusiya izi.

Zovuta ndi zovuta zina pamalo opangira jakisoni: zimachitika mofatsa nthawi zambiri pamalowa jakisoni. Izi zikuphatikiza redness pa jekeseni malo (pafupipafupi osadziwika), ululu pamalo jekeseni (pafupipafupi osadziwika), kuyabwa m'dera la jakisoni (pafupipafupi osadziwika), urticaria pamalo jekeseni (pafupipafupi osadziwika), kutupa m'malo a jakisoni (pafupipafupi osadziwika) kapena kutupa pamalo opangira jakisoni (pafupipafupi osadziwika).

Zinthu zomwe zimatchulidwa kwambiri ndi insulin pamalo opangira jakisoni nthawi zambiri zimatha patatha masiku angapo kapena milungu.

Malangizo apadera

Ngati vuto la glycemic likulephera kapena ngati matendawa ali ndi vuto la hyper- kapena hypoglycemia, musanaganize zosintha muyezo wa insulin, onetsetsani kuti mwalamulira insulin, onetsetsani kuti insulin ili ndi njira yolimbikitsira ndi zina zonse zomwe zingakhudze zotsatira za insulin. Chifukwa kugwiritsa ntchito munthawi yomweyo mankhwala angapo (onani "Kuchita") kungafooketse kapena kupititsa patsogolo mphamvu ya hypoglycemic ya mankhwala a Insuman ® Basal GT, pogwiritsa ntchito simungatenge mankhwala ena popanda chilolezo chapadera kuchokera kwa dokotala.

Hypoglycemia. Zimachitika ngati mlingo wa insulini uposa kufunika kwake. Chiwopsezo cha kukhala ndi hypoglycemia ndi chachikulu pamayambiriro a chithandizo cha insulin, mukasinthira kukonzekera kwina kwa insulin, mwa odwala omwe ali ndi shuga yayitali m'magazi.

Monga ndi ma insulin onse, chisamaliro chapadera chiyenera kutengedwa ndikuwunika kwambiri kuchuluka kwa shuga m'magazi omwe odwala hypoglycemic episode angakhale ndi vuto lapadera la matenda, monga odwala omwe ali ndi vuto lalikulu la mitsempha kapena matenda a mitsempha (chiwopsezo cha mtima kapena matenda a m'magazi a hypoglycemia), akulimbikitsidwa. , komanso odwala omwe ali ndi proliferative retinopathy, makamaka ngati sanakhalepo ndi Photocoagulation (laser therapy), chifukwa ali ndi chiopsezo chocheperako amaurosis (khungu lathunthu) ndi kukula kwa hypoglycemia.

Pali zisonyezo zina zamankhwala ndizizindikiro zomwe zimayenera kuwonetsa kwa wodwala kapena ena za kukhala ndi hypoglycemia. Izi zikuphatikiza: thukuta kwambiri, chinyezi pakhungu, tachycardia, kusokonezeka kwa mtima, kuchuluka kwa magazi, kupweteka pachifuwa, kunjenjemera, njala, kugona, kusokonezeka kwa kugona, mantha, kukhumudwa, kusayenda bwino, nkhawa, kuvulala kwa nthawi mkamwa ndi kuzungulira pakamwa, kutsekeka kwa khungu, kupweteka mutu, kusokonekera kwa kayendedwe ka kayendedwe, komanso kuchepa kwa minyewa yamitsempha yamagazi (kufooka kwa mawu ndi masomphenya, zizindikiro zakuwala) ndi zomveka zachilendo. Ndi kuchepa kwakukulu kwa ndende ya glucose, wodwalayo amatha kulephera kudziletsa komanso ngakhale kuzindikira. Zikatero, kuzizira ndi chinyezi pakhungu kumatha kuonedwa, ndipo kupweteka kumawonekeranso.Chifukwa chake, wodwala aliyense yemwe ali ndi matenda a shuga omwe amalandila insulin ayenera kuphunzira kuzindikira zizindikiro zosadziwika zomwe ndi chizindikiro cha kukhala ndi hypoglycemia. Odwala omwe nthawi zonse amayang'anira kuchuluka kwa shuga m'magazi samatha kukhala ndi hypoglycemia. Wodwalayo amatha kukonza kuchepa kwa kuchuluka kwa shuga m'magazi omwe adazindikira mwa kudya shuga kapena zakudya zambiri zamagulu ochulukitsa. Pazifukwa izi, wodwalayo ayenera kukhala ndi 20 g shuga nthawi zonse.

Mokulira kwambiri kwa hypoglycemia, jakisoni wokhazikika wa glucagon akuwonetsedwa (omwe angathe kuchitidwa ndi dokotala kapena antchito oyamwitsa). Pambuyo pakusintha kokwanira, wodwalayo ayenera kudya. Ngati hypoglycemia singathetsedwe mwachangu, ndiye kuti dokotala akuyenera kuyitanidwa mwachangu. Ndikofunikira kudziwitsa dokotala mwachangu za kukula kwa hypoglycemia kuti apange chisankho pakufunika kusintha kwa insulin. Kulephera kutsatira zakudya, kudumpha jakisoni wa insulin, kuchuluka kwa insulini chifukwa cha matenda opatsirana kapena matenda ena, komanso kuchepa kwa zochitika zolimbitsa thupi kungayambitse kuchuluka kwa shuga wamagazi (hyperglycemia), mwina ndi kuchuluka kwa matupi a ketone m'magazi (ketoacidosis). Ketoacidosis imatha kumatha maola ochepa kapena masiku. Pazizindikiro zoyambirira za metabolic acidosis (ludzu, kukodza pafupipafupi, kulephera kudya, kutopa, khungu lowuma, kupuma kwambiri komanso kuthamanga, chidwi cha acetone ndi glucose mkodzo), chithandizo chamankhwala chofunikira ndichofunikira.

Pakusintha dokotala (mwachitsanzo, nthawi yakuchipatala chifukwa cha ngozi, kudwala panthawi yopuma), wodwalayo ayenera kudziwitsa dokotala kuti ali ndi matenda ashuga.

Odwala ayenera kuchenjezedwa za mikhalidwe yomwe ingasinthe, osatchulidwanso kapena kuchenjeza zizindikiro zosapezekeratu pakukula kwa hypoglycemia, mwachitsanzo:

- ndi kusintha kwakukulu pakulamulira kwa glycemic,

- kukula pang'onopang'ono kwa hypoglycemia,

- odwala okalamba,

- odwala omwe ali ndi vuto la neuronomic,

- odwala omwe ali ndi matenda a shuga,

- odwala nthawi yomweyo amalandila chithandizo ndi mankhwala ena (onani "Kuchita"). Zochitika zoterezi zimatha kuyambitsa kukula kwa hypoglycemia (komanso kutayika kwa magazi) wodwalayo asanadziwe kuti akupanga hypoglycemia.

Ngati ma glycosylated hemoglobin akhazikika atazindikira, mwayi wopezeka mobwerezabwereza, wosazindikira (makamaka usiku) maganizidwe a hypoglycemia ayenera kuganiziridwanso.

Kuchepetsa chiopsezo cha hypoglycemia, wodwalayo ayenera kutsatira mosamala mlingo woyenera ndi zakudya zopatsa thanzi, kupereka jakisoni wa insulin ndikuchenjezedwa za zizindikiro za kukhala ndi hypoglycemia.

Zinthu zomwe zimawonjezera kutsimikizira kwa chitukuko cha hypoglycemia zimafuna kuwunikira mosamala ndipo zingafune kusintha kwa mlingo. Izi ndi monga:

- kusintha m'dera loyang'anira insulin,

- kuchuluka kwa chidwi ndi insulin (mwachitsanzo, kuchotsa kwa zopsinjika),

- zachilendo (kuchuluka kapena nthawi yayitali) zolimbitsa thupi,

- Matenda ogonana (kusanza, kutsegula m'mimba),

- Zakudya zokwanira

- kudumpha chakudya,

- matenda ena omwe sanawalipire a endocrine (monga hypothyroidism ndi anterior pituitary insuffence kapena adrenal cortex insuffence),

- munthawi yomweyo kugwiritsa ntchito mankhwala ena (onani. “mogwirizana”).

Matenda apakati. Pa matenda apawiri, kuyendetsa kagayidwe kolimba kumafunika. Nthawi zambiri, kuyesedwa kwa mkodzo kupezeka kwa matupi a ketone kumasonyezedwa, ndikusintha kwa insulin nthawi zambiri ndikofunikira. Kufunika kwa insulin nthawi zambiri kumachuluka.Odwala omwe ali ndi matenda amtundu wa 1 ayenera kupitiliratu kudya pang'ono, ngakhale atangomaliza kudya pang'onopang'ono kapena ngati akusanza ndipo sayenera konse kumwa insulin.

Zotsatira zamtanda. Mwa kuchuluka kwakukulu kwa odwala omwe ali ndi hypersensitivity kupita ku insulin ya nyama, ndizovuta kusinthira kwa insulin yaumunthu chifukwa cha mtanda wa immunological wa insulini ya anthu ndi insulin yochokera nyama.

Ndi chidwi chowonjezeka cha wodwalayo kuti apange insulin yakuchokera kwa nyama, komanso m-cresol, kulekerera kwa mankhwala a Insuman ® Basal GT kuyenera kuwunikira kuchipatala pogwiritsa ntchito mayeso a intradermal. Ngati mayeso a intradermal akuwonetsa hypersensitivity ku insulin ya anthu (momwe angachitire, monga Arthus), ndiye kuti chithandizo china chikuyenera kuchitika moyang'aniridwa ndi achipatala.

Kukopa pa kuyendetsa magalimoto kapena njila zina. Mphamvu ya wodwalayo yokhazikika komanso kuthamanga kwa zochitika zama psychomotor zitha kusokonezeka chifukwa cha hypoglycemia kapena hyperglycemia, komanso chifukwa chododometsa. Izi zimatha kukhala pachiwopsezo china chake munthawi yomwe maluso amafunikira (magalimoto oyendetsa kapena njira zina).

Odwala ayenera kulangizidwa kuti asamale komanso kupewa hypoglycemia poyendetsa. Izi ndizofunikira kwambiri kwa odwala omwe achepetsa kapena kusazindikira zizindikiro zomwe zikuwonetsa kukula kwa hypoglycemia, kapena okhala ndi zochitika zapafupipafupi za hypoglycemia. Mwa odwalawa, funso loti akhoza kuwayendetsa ndi magalimoto kapena njira zina ayenera kusankha payekha.

Wopanga

Sanofi-Aventis Deutschland GmbH, Germany. Industrialpark Hoechst D-65926, Bruningstrasse 50, Frankfurt, Germany.

Zodandaula za ogula ziyenera kutumizidwa ku adilesi ku Russia: 125009, Moscow, ul. Tverskaya, 22.

Tele. ((495) 721-14-00, fakisi: (495) 721-14-11.

Pankhani yopanga mankhwalawa ku Sanofi-Aventis Vostok CJSC, Russia, zodandaula za ogula ziyenera kutumizidwa ku adilesi iyi: 302516, Russia, Oryol Region, Oryol District, s / n Bolshekulikovskoye, ul. Livenskaya, 1.

Tele./fax: +7 (486) 2-44-00-55.

Zowonetsa ndi zotsutsana: zotheka zoyipa

Zisonyezo zogwiritsidwa ntchito muzipatala zamatenda a insulin Bazal ndi amtundu wa 2 ndi matenda amtundu wa 2, pamene kuphatikiza kwa mankhwala a hypoglycemic ndi insulin kufunikira.

Mankhwalawa amatsutsana ngati munthu samvera mwanjira ina imodzi ya anamnesis. Osamapereka mahomoni kwa odwala omwe ali ndi vuto la hypoglycemia.

Ngati pali zochitika zotsatirazi, ndiye kuti Insuman Bazal GT imagwiritsidwa ntchito mosamala kwambiri ndikuyang'aniridwa kwachipatala:

• Mwa anthu achikulire.
• Ndi osakwanira impso ndi chiwindi ntchito.
• Odwala ndi stenosis a mitsempha ya ubongo.
• Diognolative retinopathy wodziwika bwino, makamaka osathandizidwa ndi Photocoagulation.
• Intercurrent pathologies momwe kufunika kwa insulin kumachulukira.

Odwala pa hypoglycemia amatsutsana

Iliyonse mwa mikhalidwe imeneyi imafunikira kuthandizidwa ndi dokotala yemwe angaganize ngati insulini yochepa kapena yayitali ndiyothandiza wodwala winawake komanso momwe angagwirizanitsire kayendedwe ka mankhwala awo.

Chithandizo cha matenda ashuga mwa amayi apakati sichitha kuyimitsidwa. Insuman Bazal GT simadutsa placenta, zomwe zikutanthauza kuti sizikhudza mwana. Ngati matenda ashuga amapezeka panthawi yomwe ali ndi pakati (gestational), ndikofunikira kuwongolera kuchuluka kwa shuga panthawi yonse ya bere. Mu trimester yoyamba, kufunika kogwiritsira ntchito insulin kungakhale kochepa, ndipo mu 2 ndi 3 kumatha kuwonjezeka. Pambuyo pobadwa, pali kuchepa kwa kufunikira kwa mahomoni. Mukuyamwitsa, palibe zotsutsana pakusankhidwa kwa Insuman Bazal.

Zotsatira zoyipa zimatha kuchitika mukamagwiritsa ntchito Mlingo wawukulu wa insulin kapena kuphwanya kwake. Chithandizo chilichonse cha insulin chitha kukhala chovuta ndi boma la hypoglycemia. Vutoli limachitika pokhapokha ngati mankhwala omwe amaperekedwa ndi akulu kuposa kufunika kwa thupi. Izi zimawonedwa mwa anthu achikulire, tikadumphira chakudya, koma jekeseni ndi insulin, kulimbitsa thupi kwambiri, kumwa mowa, usiku. Malinga ndi zofooka zamankhwala, zikuwonekeratu kuti shuga yatsika kwambiri:

• Kutuluka thukuta mwadzidzidzi.
• Kumva njala.
• Kusinza kwachidziwitso ndi kusokonezeka kwa kugona.
• Kusokonezeka maganizo.
• Zizindikiro zamitsempha (paresthesia, kupweteka mutu, mavuto ndi mgwirizano wamachitidwe, kusintha kwamalankhulidwe ndi masomphenya, syndromes ya paralos).

Kutseguka kwa gawo lachisoni la dongosolo lodziyimira payekha kumabweretsa kulumikizidwa kwakukuru, thukuta, kupuma movutikira, arrhythmias, kupweteka kwa kuchuluka kwa mtima, kuthamanga kwa magazi.

Chitetezo cha mthupi chimatha kuyankha ku makina a Insuman Bazal GT ndi matupi awo sagwirizana, bronchospasm, angioedema, komanso kawirikawiri anaphylactic.

Odwala omwe ali ndi chidwi chodziwika bwino ndi insulin ya nyama, ndizovuta kusintha kukonzekera kwaumunthu komwe kumachokera ku ma genetic engineering. Kenako, kuyezetsa zamkati kumachitika komwe kumathandizira kuzindikira kusintha kwa hypersensitivity.

Insulin ikhoza kuyambitsa kusungidwa kwa sodium m'magazi, motero ndikotheka kupanga edema panthawi yamankhwala.

Ngati simusintha jakisoni wa insulin, ndiye kuti amakhala ndi mafuta amkati am'mimba ndipo mayamwidwe amachepetsa. Komanso, kupweteka, kufiyanso, kumachitika ngati ming'oma, kuyimitsidwa ndi kutupa kumatha kuwoneka m'ndondomeko ya jekeseni. Nthawi zambiri, pakatha masiku ochepa, izi zimachitika.

Kwa okalamba, kufunika kwa insulin kumakhala kotsika, zomwe zikutanthauza kuti mlingo umasankhidwa mosamala kuti usayambitse hypoglycemia

Njira ya makonzedwe

Malangizo ogwiritsira ntchito Insuman Bazal GT imapereka kusankha kwa munthu payekha, potengera momwe wodwalayo alili komanso kufunika kwake kwa mahomoni. Mlingo amawerengedwa ndi kuchuluka kwa shuga m'magazi, zolimbitsa thupi, mkhalidwe wa kagayidwe kazakudya.

Pafupifupi, 0,5-1.0 Insuman Bazal GT imafunikira patsiku pafupifupi 1 kg ya kulemera kwamthupi la wodwala. Amaphatikizidwanso ndi insulin yokhala ndi nthawi yayitali, makamaka kuchokera kwa wopanga yekha. Kusintha kwa magazi kumachitika potsatira milandu iyi:

• Kusintha kuchokera ku insulin ya nyama.
• Kusintha kwa mankhwala opanga majini amtundu wa anthu.
• Kusintha kwa sungunuka wa munthu insulin ndi yotalikirapo.
• Kuchulukitsa kapena kuchepa kwa odwala komanso kuchita masewera olimbitsa thupi.
• Zomwe zimapangidwira kukula kwa hyper- kapena hypoglycemia.

Mlingo wa okalamba umasinthidwa. Kwa okalamba, kufunika kwa insulini kumakhala kotsika, motero, mankhwalawa amasankhidwa ndikuwusintha mosamala kwambiri kuti asayambitse vuto la hypoglycemia. Odwala omwe ali ndi matenda a chiwindi ndi impso omwe adutsa gawo la kusakwanira kwa ntchito, kuchepetsa mlingo kumafunika.

Bazal GT phukusi lomwe lili ndi Mbale 5 za mankhwala mu 5 ml. Ikupezekanso m'mak cartridge atatu. Kuti mupeze jakisoni, mphindi 45-60 musanadye, kuchuluka kwa kuyimitsidwa kumasonkhanitsidwa mu syringe ya insulin. Lowani mosaneneka mu khola pamimba, m'chiuno. Tsamba la jakisoni limasinthidwa nthawi ndi nthawi ndikusinthidwa pakulimbikitsidwa ndi dokotala. Kuchuluka kwa kumizidwa m'magazi ndikukula kwa zotsatira zake zimatengera izi. Izi zaletsedwa kuchita izi:

• Muuzeni mankhwalawo.
• Gwiritsani ntchito pampu ya insulin.
• Sakanizani jakisoni m'modzi ndi mitundu ina ya kukonzekera kwa insulin, kuphatikiza chiyambi cha nyama, komanso ndende ina.

Musanadzaze yankho mu syringe, muyenera kutembenuzira botolo ndikuwugwedeza kuti apange kuyimitsidwa. Siyenera kukhala yopanda thovu ndikukhala ndi utoto wosiyana ndi omwe akuwonetsedwa mu malangizo.Ngati, mutagwedezeka, mapepala ndi ziphuphu zimapangidwa pagalasi, ndiye kuti mankhwalawa sangathe kugwiritsidwa ntchito.

Mukatha kugwiritsa ntchito koyamba, vial imatha kusungidwa kwa masabata anayi pa kutentha osaposa 25 digiri, kutetezedwa ndikuwala. Pofuna kuti musaiwale, tsiku lotsegulira likuwonetsedwa. Sikulimbikitsidwa kuyika mabotolo otseguka mufiriji: kubayidwa ndi jakisoni wozizira kumapangitsa kupweteka kwambiri.

Analogi ndi mtengo

Mtengo wa Insuman Bazal, kutengera kuchuluka kwa mabotolo, umachokera ku 268 mpaka 1695 rubles. Mtengo umasiyana m'magawo osiyanasiyana a Russia ndi ma pharmacista opezeka pa intaneti.

Rinsulin NPH (mtengo kuchokera ku ma ruble 420), Biosulin (kuchokera ku ma ruble 500), Protamine Insulin Emergency Situations (310 rubles), Rosinsulin (kuchokera ku ruble 1000) atha kukhala fanizo la Insuman Bazal.

M'malo moyenerera mankhwalawa amatha kusankha dokotala woyenera yekha. Chifukwa chake, pankhani ya insulin yothandizira matenda a shuga, kudzichiritsa nokha kuli kowopsa.

Nambala yolembetsa : P No. 011994/01 ya Julayi 26, 2004

1 ml ya kuyimitsidwa kosaloledwa kwa jakisoni ali ndi 100 IU ya insulin ya anthu (100% crystalline insulin protamine).
Omwe amathandizira: protamine sulfate, m-cresol, phenol, zinc chloride, sodium dihydrogen phosphate dihydrate, glycerol, sodium hydroxide, hydrochloric acid, madzi a jekeseni.

Kutulutsa mafomu, mtengo wake

Insulin basal imapezeka ngati subcutaneous kuyimitsidwa mu Mlingo wa 100 IU / ml. Mtundu woyamba wamasulidwa ndi mabotolo a galasi owoneka bwino. Mbali yapamwamba ya botolo imatsekedwa ndi choletsa, pomwe amavala chipewa cha aluminium. Kuti ziwonjezeke, chipewa cha pulasitiki chimayikidwa pamwamba pa chipewa. Kuchuluka kwa botolo ndi 5 ml. Patsamba la mankhwala, insulin Bazal imatha kuwoneka m'matumba a ma ampoules asanu omwe ali ndi malangizo ogwiritsa ntchito.

Mtundu wotsatira wa kumasulidwa ndi makatoni omwe amapangidwa ndi galasi lomveka bwino lomwe lili ndi 3 ml. Pamwamba pa katiriji wokutidwa ndi chowiyimitsa, ndipo chovala cha aluminium chimavalidwa. Gawo lakumapeto limatsirizika ndi plunger. Kuphatikiza apo, pali mipira itatu yachitsulo katiriji. Phukusi lililonse limakhala ndi ma cartridge 5. Amafunanso cholembera.

Fomu lachitatu lomasulidwa ndi makatoni ku SoloStar disposable syringe pens. Amapangidwa ndi galasi lomveka bwino lomwe lili ndi 3 ml. Kunja, cartridge imawoneka chimodzimodzi monga momwe idalili kale. Pamwamba pa cork pali kapu ya aluminium pamwamba. Gawo lakumunsi la cartridge limatha ndi plunger. Kathumba kalikonse kamakhala ndi mipira 3 yachitsulo. Poterepa, phukusi limakhala ndi zolembera 5 ndi malangizo ogwiritsira ntchito.

Mtengo wapakati wa mankhwalawa umasiyanasiyana pafupifupi ma ruble 1000. Mtengo umatengera mtundu womwe wasankhidwa kuti amasulidwe.

Makhalidwe wamba. Zopangidwa:

Zothandiza: insulin ya anthu (100% crystalline protamine insulin) - 3,571 mg (100 IU),
excipients: protamine sulfate - 0,318 mg, metacresol (m-cresol) - 1,500 mg, phenol - 0,600 mg, zinc chloride - 0,047 mg, sodium dihydrogen phosphate dihydrate - 2,100 mg, glycerol (85%) - 18,824 mg, sodium hydroxide (wogwiritsidwa ntchito) kusintha pH) - 0.576 mg, hydrochloric acid (amagwiritsidwa ntchito kusintha pH) - 0,246 mg, madzi a jakisoni - mpaka 1,0 ml.
Kufotokozera: Kuyimitsidwa kwa koyera kapena pafupifupi koyera, kosavuta kufalitsa.

Katundu

Mankhwala Insuman® Basal GT imakhala ndi insulin yofanana mu insulin yaumunthu ndipo yopezeka ndi mainjinier ogwiritsira ntchito E. coli K12 kufinya 135 pINT90d. Limagwirira zake insulin:
- amachepetsa kuchuluka kwa shuga m'magazi, amalimbikitsa zotsatira za anabolic komanso amachepetsa zotsatira za ma catabolic,
- kumawonjezera kusintha kwa shuga m'maselo ndi mapangidwe a glycogen mu minofu ndi chiwindi ndikuwongolera kugwiritsa ntchito pyruvate, tikuletsa glycogenolysis ndi glyconeogeneis,
- kumawonjezera lipogenesis mu chiwindi ndi adipose minofu ndi ziletsa lipolysis,
- amalimbikitsa kutulutsa kwa amino acid mu maselo ndi kaphatikizidwe wa mapuloteni,
- kumawonjezera kutuluka kwa potaziyamu m'maselo.
Insuman® Basal GT ndi insulin yokhala ndi nthawi yayitali ndikuyamba pang'ono pang'ono. Pambuyo pa subcutaneous makonzedwe, mphamvu ya hypoglycemic imachitika mkati mwa ola limodzi, ndikufika pazokwanira mkati mwa maola 3-4. Zotsatira zimapitirira kwa maola 11 mpaka 20.

Pharmacokinetics Mwa anthu athanzi, theka la moyo wa plasma insulin pafupifupi mphindi 4-6. Odwala omwe ali ndi vuto lalikulu la impso, amatenga nthawi yayitali. Komabe, ziyenera kudziwidwa kuti pharmacokinetics ya insulin sikuwonetsa metabolic yake.

Kusintha kwa mlingo wowonjezera

Ndi bwino kagayidwe kachakudya, kuwonjezeka kwa insulin sensitivity ndikotheka, chifukwa chomwe kufunika kwa thupi kumachepa.

Kusintha kwa mlingo wa Insuman Bazal GT kungakhale kofunikira ngati wodwalayo wasintha moyo wake (mulingo wakuchita zolimbitsa thupi, kudya, ndi zina), kulemera kwa thupi ndi / kapena zochitika zina, chifukwa cha zomwe zikuwonjezera kulosera kwatsoka la hyper- kapena hypoglycemia.

Kufunika kwa insulini kumatha kuchepa kwa odwala omwe ali ndi vuto laimpso / chiwindi, mwa okalamba. Pankhaniyi, kusankha kwa Mlingo woyambirira ndikukonzanso kuyenera kuchitika mosamala kwambiri (pofuna kupewa chitukuko cha hypoglycemic).

Ikani Insuman Bazal GT m'mabotolo

1. Chotsani kapu ya pulasitiki m'botolo.
2. Sakanizani kuyimitsidwa bwino: tengani vial pamtunda wapakati pakati pa manja anu ndikuchepetsa (popewa kufumbwa) mutembenuzire.
3. Sungani mpweya mu syringe mu voliyumu yolingana ndi kuchuluka kwa insulini, ndikuyiyika mu vial (osayimitsidwa).
4. Popanda kuchotsa syringe, tembenuzani botolo pansi ndikujambulani mankhwalawo.
5. Chotsani thovu zam'mlengalenga mu syringe.
6. Sonkhanitsani khola ndi zala ziwiri, ikani singano m'munsi mwake ndikulowetsa insulini pang'onopang'ono.
7. Pang'onopang'ono, chotsani singano ndikufinya jakisoniyo ndi swab ya thonje kwa masekondi angapo.
8. Lembani tsiku la cholembera choyamba pa cholembera.

Ikani Insuman Bazal GT mu makatoni

Cartridges adapangidwa kuti azigwiritsidwa ntchito ndi zolembera za systinge ya ClickStAR ndi OptiPen Pro1. Asanaikidwe, cartridge iyenera kusungidwa kutentha kwa maola 1-2, popeza kuti jakisoni wa insulin yozizira ndi wowawa. Kenako muyenera kusakaniza kuyimitsidwa kukhala dziko lokhala ndi vuto: pang'onopang'ono mutembenuzire cartridge pafupifupi nthawi 10 (katiriji iliyonse imakhala ndi mipira itatu yachitsulo yomwe imakulolani kusakaniza mwachangu zomwe zili).

Ngati katiriji waikapo kale cholembera, mutembenuzire pamodzi ndi cartridge. Njirayi iyenera kuchitidwa isanayambike iliyonse ya Insuman Bazal GT.

Cartridges sanapangidwe kuti aphatikize mankhwalawo ndi mitundu ina ya insulin. Zopanda zopanda kanthu siziyenera kudzazidwa. Pakachitika kuphwanya syringe, gawo loyenera kuchokera pa cartridge limatha kutumizidwa pogwiritsa ntchito syrile yonyowa, yongogwiritsa ntchito syringe yokha yapulasitiki yomwe idapangidwira insulin iyi.

Mukayika makatoni atsopano musanalowetse muyeso woyamba, muyenera kuyang'ana kuyenera kwa cholembera.

Malo opumulira:

Kuyimitsidwa kwa subcutaneous makonzedwe a 100 IU / ml.
5 ml ya mankhwalawa mu botolo la galasi looneka komanso lopanda utoto (mtundu I). Botolo limapangidwa m'maso, limafinya ndi chipewa cha aluminium ndikutchinga ndi kapu ya pulasitiki yoteteza. Mbale 5 yokhala ndi malangizo ogwiritsira ntchito pabokosi lamakatoni.
3 ml ya mankhwalawa mu katoni yamagalasi oyera ndi opanda khungu (mtundu I). Katirijiyo amakhazikika mbali imodzi ndi nkhata ndipo imamizidwa ndi kapu ya aluminiyamu, mbali inayo - ndi phula. Kuphatikiza apo, mipira 3 yachitsulo imayikidwa katiriji. Makatoni asanu pazinthu zilizonse za filimu ya PVC ndi zojambulazo.Mzere umodzi wa blister pamodzi ndi malangizo ogwiritsira ntchito pabokosi la makatoni.
3 ml ya mankhwalawa mu katoni yamagalasi oyera ndi opanda khungu (mtundu I). Katirijiyo amakhazikika mbali imodzi ndi nkhata ndipo imamizidwa ndi kapu ya aluminiyamu, mbali inayo - ndi phula. Kuphatikiza apo, mipira 3 yachitsulo imayikidwa katiriji. Makatoni amaikamo cholembera cha SoloStar®. Pa 5 SoloStar sy syringe pensulo limodzi ndi malangizo ogwiritsira ntchito pakatoni.

Pakati pamafakitala ambiri amtundu wa anthu, malo apadera omwe amakhala ndi mankhwala osokoneza bongo nthawi yayitali. Chofunikira kwambiri ndi kugwiritsidwa ntchito kogwiritsa ntchito mkati Chithandizo cha matenda a shuga amtundu 1 komanso matenda amitundu iwiri matenda ashuga. Opanga mankhwalawa ndi Sanofi-Aventis.

Insulin Insuman Bazal imatha kukhala yothandiza kwambiri pakulipira matenda ashuga okhazikika (motsutsana ndi kumbuyo kwa hyperglycemia yokhala ndi shuga m'magazi). Amagwiritsidwa ntchito ngati mankhwala a insulini apamwamba kwambiri omwe ali ndi jakisoni awiri (m'mawa ndi madzulo) wa mahomoni opanga a nthawi yayitali.

Cholinga chachikulu cha mankhwalawa ndikutsatira secretion yachilengedwe, yomwe nthawi zambiri imapangidwa ndi kapamba tsiku lonse. Kuchita kwa mankhwalawa kumayambira maola 1-1,5 pambuyo pa kuperekedwa pansi pa khungu, kumatenga maola 11 mpaka 20. Peak imagwera pamtunda wa maola 4-6 kuchokera poyambira kukonzekera. Kutalika kwa ntchito zimatengera mlingo wosankhidwa wa jekeseni, mawonekedwe a thupi. Nthawi zambiri, musanadye chakudya cham'mawa, mankhwalawa amagwiritsidwa ntchito mphindi 45-55 musanadye.

Kuti mupeze chiphuphu choyenera, ndikofunikira kuti musankhe mankhwalawa kuchipatala chapadera poganizira mbiri ya glycemic ya tsiku ndi tsiku. Posamutsa wodwala kuchokera ku insulin ya insulin kupita kwa anthu, nthawi zambiri, kuchepetsa njira yofunikira kumafunikira. Ndikofunika kwambiri kuyandikira kusankha kuchuluka kwa mankhwalawa kwa odwala ochepa komanso omwe akufunika thandizo pang'ono kuchokera ku mahomoni akunja kuti mupewe owopsa.

Insuman Bazal gt ndi yoyenera kwa subcutaneous makonzedwe. Amakhulupirira kuti kugwiritsidwa ntchito kwake kumatha kubwezeretsa chidwi cha maselo ku mahomoni ake, motero, ndi matenda a shuga a 2, mankhwala a insulin nthawi zambiri amakhala osakhalitsa.

Kuti muwongolere mankhwalawa, mutha kugwiritsa ntchito syringe wamba kapena cholembera chamakono cha syringe . Kugwiritsa ntchito kachipangizako kungachepetse jakisoni tsiku ndi tsiku, kusintha moyo wa wodwala. Maonekedwe a chipangizocho komanso kukula kwake kwa zinthuzo ndizosangalatsa.

Mutha kusakaniza mankhwalawa ndi mankhwala ena a Sanofi-Aventis ngati masisitere awo ali ofanana (i. 100 ndi 40 / mphindi 40 / ml sizingasakanikirane!). Komanso, saloledwa kuphatikiza mankhwalawa ndi ma insulin a nyama, mankhwala omwe amapangidwa kuti athandizidwe kupopa pampu ndi analogi m'botolo imodzi.

Kumbukirani: posakanikirana ndi syringe, mahomoni ochita kupanga mwachidule nthawi zonse amakhala oyamba kutayidwa!

Insuman Rapid

Insulin yomanga yaumunthu imagwiritsidwa ntchito mosamala pochiza matenda ashuga. Amatanthauzira kugwiritsa ntchito mankhwala osokoneza bongo kwakanthawi. Imayamba kugwira ntchito pambuyo mphindi 50, imawoneka momwe ingathere pakadutsa maola 1-4, imakhalabe yogwira mpaka maola 7. Mtengo wotchulidwa umakupatsani mwayi wokonza chakudya chamtundu wambiri kwa nthawi yayitali, kusintha kaimidwe kadongosolo malinga ndi mbiri ya mankhwalawo.

Amabayidwa pansi pakhungu ndi syringe ya insulini. Palinso ma syringe apadera a Solostar. Zida zotayidwa pambuyo pa kutha kwa cartridge ziyenera kuwonongeka.

Ndi yabwino kwambiri kulipira anthu achikulire omwe amatha kutsatira chizolowezi cha tsiku ndi tsiku ndikukonzekera bwino zolimbitsa thupi. Amagwiritsidwa ntchito ngati mankhwala akuluakulu mwa ana omwe amafunikira kwambiri insulin. Ili ndi zotsatira zabwino pakupangidwe kwa masitolo a glycogen m'chiwindi ndi minofu.

Zotsatira zoyipa kwambiri ndi hypoglycemia. Nthawi zambiri zimachitika ngati mulingo womwewo utatsitsidwa mosatsata. Thupi lawo siligwirizana nthawi zina limachitika mu uritisaria, edema yakuda, ndi kuyabwa. Yoyenera kuphatikiza mapiritsi a mankhwala ochepetsa shuga pakukulimbikitsani kwa dokotala.

Kugwiritsa ntchito bwino chithandizo. Sichifuna discontinuation pa mkaka wa m`mawere. Mlingo ungasiyane kutengera zosowa za thupi.

Vala lotseguka la Insuman Rapid kapena Insuman Bazal gt limatha kugwira ntchito masiku 28. Amasungidwa kutentha firiji, kuzizira sikuloledwa. Botolo yatsopanoyo iyenera kukhala yotentha + 2 + 8 osapitirira zaka ziwiri. Tsiku lotha litatha, kugwiritsa ntchito kumatha kukhala koopsa thanzi.

Kumbukirani, njira zilizonse zochizira matenda a endocrine pathologies zitha kugwiritsidwa ntchito mutakambirana ndi adokotala! Kudzipatsa nokha mankhwala kukhala koopsa.