Amoxicillin Sandoz - malangizo a boma ogwiritsira ntchito

Amoxicillin Sandoz: malangizo ogwiritsira ntchito ndi kuwunika

Dzina lachi Latin: Amoxicillin Sandoz

Code ya ATX: J01CA04

Zogwira pophika: amoxicillin (Amoxicillin)

Wopanga: Sandoz, GmbH (Sandoz, GmbH) (Austria)

Sinthani mafotokozedwe ndi chithunzi: 07/10/2019

Mitengo muma pharmacies: kuchokera ku 123 rubles.

Amoxicillin Sandoz ndi mankhwala ochokera ku gulu la semisynthetic penicillin.

Kutulutsa mawonekedwe ndi kapangidwe kake

Mlingo wambiri - mapiritsi okhala ndi filimu: oblong (0,5 g iliyonse) kapena chowulungika (1 g aliyense), biconvex, ndi zikwangwani mbali zonse ziwiri, kuyambira zoyera mpaka pang'ono zachikaso (mulingo wa 0,5 g: 10 ndi 12) ma PC, matuza, mu kakhadakhadi 1 mthumba ndi malangizo ogwiritsira ntchito Amoxicillin Sandoz, ma CD a zipatala - mu katoni 100 matuza 10 mapiritsi, mulingo 1 g: 6 ndi 10 ma PC mu matuza, pamatumba awiri matuza ndi malangizo kwa mankhwala, atanyamula zipatala - pabokosi lamatabwa 100 matuza).

Piritsi 1:

• yogwira mankhwala: amoxicillin (mu mawonekedwe a trihydrate) - 0,5 kapena 1 g,
• othandizira: microcrystalline cellulose, povidone, sodium carboxymethyl starch (mtundu A), magnesium stearate,
• filimu pachimake: hypromellose, talc, titanium dioxide.

Mankhwala

Amoxicillin - wogwira pophika mankhwala - penicillin wopangidwa ndi bactericidal.

Makina ochitapo kanthu ndi chifukwa cha mphamvu ya amoxicillin kuwononga cell membrane wa mabakiteriya mu gawo lakubala. Mankhwalawa amalepheretsa ma michere a cell membrane a ma cellorganism (peptidoglycans), zomwe zimapangitsa kuti aziyamwa komanso kufa.

Amoxicillin Sandoz amagwira ntchito motsutsana ndi mabakiteriya otsatirawa:

• Ma grorgan-aerobic tizilombo tating'onoting'ono: Streptococcus spp. (kuphatikiza S. pneumoniae), Listeria monocytogene, Enterococcus faecalis, Bacillus anthracis, Staphylococcus spp. (kupatula penicillinase wotulutsa tinthu tating'onoting'ono), Corynebacterium spp. (kupatula C. jeikeium),
• gram-negative aerobic tizilombo: Neisseria spp., Borrelia spp., Shigella spp., Helicobacter pylori, Escherichia coli, Salmonella spp., Campylobacter, Haemophilus spp., Proteus mirabilis, Leptospira spp., Treponema spp.
• mabakiteriya a anaerobic: Fusobacterium spp., Bacteroides melaninogenicus, Peptostreptococcus spp., Clostridium spp.,
• Ena: Chlamydia spp.

Amoxicillin Sandoz sagwira ntchito yolimbana ndi tizilombo:

• Bakiteriya wa a Gerobic wabwino: Staphylococcus (mabala opanga lactamase),
• mabakiteriya a grob-negative aerobic: Klebsiella spp., Proteus spp., Acinetobacter spp., Pseudomonas spp., Serratia spp., Moraxella catarrhalis, Enterobacter spp, Providencia spp.,
• mabakiteriya a anaerobic: Bacteroides spp.,
• Ena: Rickettsia spp., Mycoplasma spp.

Pharmacokinetics

Pambuyo pakamwa Mlingo wa Amoxicillin Sandoz 0,5, plasma ndende ya mankhwalawa imachokera 6 mpaka 11 mg / L. Nthawi yofika ndende yozama ya plasma ndi ma maola 1-2. Kudya sikukhudza kuyamwa (kuthamanga ndi digiri). Mtheradi bioavailability amadalira mlingo mu chilengedwe ndipo akhoza kukhala 75-90%.

15-25% ya mlingo wolandiridwa umamangidwa ndi mapuloteni a plasma. Amoxicillin amalowa mwachangu mu bile, kupuma kwa bronchial, minofu yam'mapapo, mkodzo, madzi amkati apakati. M'miyeso yaying'ono mumalowa madzi amadzimadzi, pokhapokha ngati palibe zotupa zam'mimba, apo ayi zomwe zili mumadzi amadzimadzi amatha kufika 20% ya plasma. Imalowetsa placenta, yaying'ono m'mkaka wa m'mawere.

Mpaka 25% ya mlingo wovomerezeka wa mankhwalawa umapangidwa ndi mapangidwe a penicilloic acid, omwe alibe pharmacological.

Amawonetsedwa: 60-80% ya mlingo - impso sizinasinthidwe kwa maola 6-8 mutatenga Amoxicillin Sandoz, ochepa - ndi bile.

Hafu ya moyo (T_½) ndi maola 1‒1.5, ndi kulephera kwamphuno kwakuthupi kumatha kusiyanasiyana mkati mwa maola 5‒20.

Amoxicillin amachotsedwa m'thupi nthawi ya hemodialysis.

Fomu ya Mlingo:

mapiritsi okhala ndi filimu.

Kufotokozera

Mapiritsi a Oblong (mulingo wa 0,5 g) kapena oil (mulingo wa 1.0 g) biconvex mapiritsi, okhala ndi utoto wokutidwa kuyambira kuyera mpaka pang'ono chikaso, utoto mbali zonse ziwiri.

Piritsi limodzi la 0,5 g ndi 1.0 g lili ndi:
Pakatikati
Chithandizo: amoxicillin (mu mawonekedwe a amoxicillin trihydrate) 500.0 mg (574.0 mg) ndi 1000.0 mg (1148.0 mg), motsatana.
Othandizira: magnesium stearate 5.0 mg / 10,0 mg, povidone 12.5 mg / 25.0 mg, sodium carboxymethyl wowuma (mtundu A) 20,0 mg / 40.0 mg, microcrystalline cellulose 60,5 mg / 121 mg.
Filamu wachimvekere: titanium dioxide 0,340 mg / 0.68 mg, talc 0.535 mg / 1.07 mg, hypromellose 2.125 mg / 4.25 mg.

Zizindikiro zogwiritsidwa ntchito

Amoxicillin Sandoz amagwiritsidwa ntchito pochiza matenda opatsirana komanso otupa omwe amayamba chifukwa cha mabakiteriya omwe amamva kwambiri mankhwala:

• Ziwalo zamtundu wa ENT, thirakiti ya kupweteka kwapakati komanso yotsika: pachimake otitis media, tonsillitis, pharyngitis, chibayo, bronchitis, abscess ya m'mapapo,
• Dongosolo la genitourinary: cystitis, endometritis, adnexitis, septic, pyelitis, pyelonephritis, epididymitis, urethritis, bacterial prostatitis, etc.
• m'mimba thirakiti: bakiteriya enteritis (matenda oyambitsidwa ndi tizilombo ta anaerobic, mankhwalawa amagwiritsidwa ntchito ngati gawo la mankhwala osakanikirana),
• bile ducts: cholecystitis, cholangitis,
• listeriosis, leptospirosis, matenda a Lyme (borreliosis),
• matenda a pakhungu ndi minofu yofewa,
• endocarditis (kuphatikizapo kupewetsa kwake mkati mwa njira ya mano).

Komanso mapiritsi a Amoxicillin Sandoz amagwiritsidwa ntchito ngati gawo la mankhwala osakanikirana (pamodzi ndi clearithromycin, metronidazole kapena proton pump inhibitors) kuti athetse Helicobacter pylori.

Contraindication

• ana osakwana zaka 3,
• Hypersensitivity kwa mankhwala ena a beta-lactam, mwachitsanzo, cephalosporins kapena carbapenems (pamtanda ungayambike),
• yoyamwitsa
• kuchuluka kwa chidwi chilichonse cha mankhwala kapena penicillin.

Mapiritsi a Amoxicillin Sandoz ayenera kugwiritsidwa ntchito mosamala potsatira milandu:

• kupukusa kwambiri m'mimba, limodzi ndi kutsegula m'mimba kwa nthawi yayitali / kusanza,
• kuwonongeka kwaimpso,
• matenda opatsirana ndi ma virus
• Mphumu ya bronchial,
• matupi awo sagwirizana
• matenda mononucleosis (kuchuluka chiopsezo cha erythematous zotupa pa khungu),
• pachimake lymphoblastic leukemia,
• Ana opitilira zaka 3,
• kutenga pakati (phindu kwa mayi liyenera kupitilira zoopsa za mwana wosabadwayo).

Pharmacodynamic kanthu

Mankhwala
Amoxicillin ndi penicillin wopanga wocheperako wokhala ndi bactericidal.
Kupanga kwa bactericidal zochita za amoxicillin kumalumikizidwa ndikuwonongeka kwa cell membrane wa bakiteriya pakufalikira. Amoxicillin amalepheretsa ma enzymes a cell cell nembanemba (peptidoglycans), zomwe zimapangitsa kuti aziyamwa komanso kufa.
Yogwira:
Bakiteriya wabwino wa aerobic
Bacillus anthracis
Corynebacterium spp. (kupatula Corynebacterium jeikeium)
Enterococcus faecalis
Listeria monocytogene
Streptococcus spp. (kuphatikiza Streptococcus pneumoniae)
Staphylococcus spp. (kupatula penicillinase wotulutsa tinthu tosiyanasiyana).
Bakiteriya wa a grob-aerobic
Borrelia sp.
Escherichia coli
Haemophilus spp.
Helicobacter pylori
Leptospira spp.
Neisseria spp.
Proteus mirabilis
Salmonella spp.
Shigella spp.
Treponema spp.
Campylobacter
Zina
Chlamydia spp.
Mabakiteriya a Anaerobic
Bacteroides melaninogenicus
Clostridium spp.
Fusobacterium spp.
Peptostreptococcus spp.
Zosagwira pa:
Bakiteriya wabwino wa aerobic
Staphylococcus (β-lactamase zopangira)
Bakiteriya wa a grob-aerobic
Spinetobacter spp.
Citrobacter spp.
Enterobacter spp.
Klebsiella spp.
Moraxella catarrhalis
Proteus spp.
Providencia spp.
Pseudomonas spp.
Serratia spp.
Mabakiteriya a Anaerobic
Bacteroides spp.
Zina
Mycoplasma spp.
Ratchtsia spp.
Pharmacokinetics
Mtheradi bioavailability wa amoxicillin amadalira mlingo ndipo kuchokera 75 mpaka 90%. Kukhalapo kwa chakudya sikukhudza mayamwidwe mankhwala. Zotsatira zamkamwa zamkodzo wa amoxicillin mu gawo limodzi la 500 mg, kuchuluka kwa mankhwalawa mu plasma ndi 6 - 11 mg / L. Pambuyo pakukonzekera pakamwa, kuchuluka kwambiri kwa plasma kumachitika pambuyo pa maola 1-2.
Pakati pa 15% ndi 25% ya amoxicillin imamangiriza mapuloteni a plasma.
Mankhwalawa amalowerera mosavuta m'matumbo a m'mapapo, kupuma kwa bronchial, madzi apakati amkati, bile ndi mkodzo. Pakusatupa kwam'mimba, amoxicillin amalowa m'madzi amadzimadzi ochepa.
Ndi kutupa kwa meninges, kuchuluka kwa mankhwalawa m'madzi am'magazi kungakhale 20% ya kukhazikika kwake m'madzi a m'magazi. Amoxicillin amawoloka chikhodzodzo ndipo amapezeka ochepa mkaka wa m'mawere.
Mpaka 25% ya mlingo womwe umayendetsedwa zimapukusidwa ndi mapangidwe osagwira penicilloic acid.
Pafupifupi 60-80% amoxicillin amayimirira osasinthika ndi impso mkati mwa maola 6 mpaka 8 mutamwa mankhwalawa.
Pang'ono pake mankhwalawa amachotsedwa mu ndulu.
Hafu ya moyo ndi maola 1-1,5. Odwala omwe ali ndi vuto loti aimpso amalephera, theka la moyo limasiyana kuchokera maola 5 mpaka 20. Mankhwala amachotsedwa ndi hemodialysis.

Amoxicillin amasonyezedwa matenda opatsirana komanso otupa oyambitsidwa ndi mabakiteriya osagwiritsa ntchito mankhwala:
• Matenda opatsirana a kumtunda komanso kwam'munsi kupuma ndi ziwalo za ENT (tonsillitis, pachimake otitis media, pharyngitis, bronchitis, chibayo, mapapu olowa),
• Matenda opatsirana a genitourinary system (urethritis, pyelonephritis, pyelitis, bacterialitisatitis, cyidymitis, cystitis, adnexitis, mimba ya septic, endometritis, etc.),
• matenda am'mimba: bacterial enteritis. Kuphatikiza mankhwala kungafunike pamatenda oyambitsidwa ndi anaerobic tizilombo,
• Matenda opatsirana komanso otupa a biliary thirakiti (cholangitis, cholecystitis),
• kuthetsa Helicobacter pylori (kuphatikiza ndi proton pump inhibitors, clarithromycin kapena metronidazole),
• matenda a pakhungu ndi minofu yofewa,
• leptospirosis, listeriosis, matenda a Lyme (borreliosis),
• endocarditis (kuphatikizapo kupewa endocarditis munthawi ya mano).

Gwiritsani ntchito pa nthawi yoyembekezera

Kafukufuku wazinyama awonetsa kuti amoxicillin alibe embryotoxic, teratogenic ndi mutagenic kwambiri pa mwana wosabadwayo. Komabe, kafukufuku wokwanira komanso wowongolera moyenera kugwiritsa ntchito amoxicillin mwa amayi apakati sanachitike, chifukwa chake, kugwiritsa ntchito amoxicillin pa nthawi yomwe ali ndi pakati kumatha kuchitika pokhapokha ngati phindu lomwe lingapezeke kwa mayi limaposa chiwopsezo cha mwana wosabadwayo. Mankhwalawa amachotseredwa mkaka wa m'mawere, motero, mukamapatsa ndi amoksililin mkaka wa m`mawere, ndikofunikira kuthetsa vuto la kuyamwitsa, chifukwa kutsegula m'mimba ndi / kapena fungal colonization wa mucous membrane imatha kukhazikika, komanso chidwi cha beta-lactam mankhwala osokoneza bongo mwa khanda loyamwitsa.

Mlingo ndi makonzedwe

Mkati.
Chithandizo cha matenda:
Monga lamulo, chithandizo chamankhwala chikulimbikitsidwa kupitiliza kwa masiku awiri atatha kutha kwa zizindikiro za matendawa. Pankhani ya matenda obwera chifukwa cha β-hemolytic streptococcus, kuthetseratu kwathunthu kwa pathogen kumafunikira chithandizo kwa masiku osachepera 10.
Paresteral chithandizo akuwonetsedwa chifukwa cha kuthekera kwa makonzedwe apakamwa komanso kuchiza matenda oopsa.
Mlingo wa akulu (kuphatikizapo odwala okalamba):
Mulingo wamba:
Mulingo wamba umachokera pa 750 mg mpaka 3 ga amoxicillin patsiku kangapo. Nthawi zina, tikulimbikitsidwa kuti muchepetse mlingo wa 1500 mg wa tsiku patsiku zingapo.
Njira yochepa yothandizira:
Osavuta kwamikodzo thirakiti matenda: kumwa 2 ga mankhwalawa kawiri pa jekeseni iliyonse ndi gawo pakati pakati Mlingo wa maola 10-12.
Mlingo wa ana (mpaka zaka 12):
Mlingo wa tsiku ndi tsiku wa ana ndi 25-50 mg / kg / tsiku pamadontho angapo (pazipita 60 mg / kg / tsiku), kutengera ndi kuwonetsa kwa matendawa.
Ana osaposa 40 makilogalamu ayenera kulandira munthu wamkulu.
Mlingo wa kulephera kwa impso:
Odwala omwe ali ndi vuto lalikulu la impso, mlingo uyenera kuchepetsedwa. Ndi chilolezo chokhala ndi impso zosakwana 30 ml / min, kuwonjezeka kwakanthawi pakati pa Mlingo kapena kuchepa kwa Mlingo wotsatira tikulimbikitsidwa. Mu kulephera kwa aimpso, maphunziro ochepa a 3 g amatsutsana.

Akuluakulu (kuphatikiza odwala okalamba):

Aimpso kuwonongeka kwa ana masekeli zosakwana 40 makilogalamu

Kuteteza kwa Endocarditis
Pofuna kupewa endocarditis odwala osagwiritsa ntchito opareshoni, 3 g ya amoxicillin ayenera kutumikiridwa 1 ora asanachitidwe opaleshoni, ndipo ngati n`koyenera, wina 3 g pambuyo 6 maola.
Ana akulimbikitsidwa kuti apereke mankhwala amoxillin pa 50 mg / kg.
Kuti mumve zambiri komanso mafotokozedwe amitundu yamagulu omwe ali pachiwopsezo cha endocarditis, werengani malangizo omwe akuperekedwa.

Zotsatira zoyipa

Zomwe zimayambitsa zovuta zimafotokozedwa molingana ndi gradation yotsatira: pafupipafupi - kuposa 10%, pafupipafupi - kuchokera ku 1 mpaka 10%, infrequent - kuchokera ku 0,1% mpaka 1%, osowa - kuchokera ku 0,01 mpaka 0.1%, kwambiri osowa - osakwana 0.01%.
Kuchokera pamtima:pafupipafupi: tachycardia, phlebitis, zosowa: kutsitsa magazi, zosowa kwambiri: Kutalika kwa QT.
Mbali ya magazi ndi zamitsempha yamagazi:pafupipafupi: eosinophilia, leukopenia, zosowa: neutropenia, thrombocytopenia, agranulocytosis, zosowa kwambiri: kuchepa magazi (kuphatikiza hemolytic), thrombocytopenic purpura, pancytopenia.
Kuchokera ku dongosolo lamanjenje:pafupipafupi: kugona, mutu, chizungulire, zosowa: mantha, kukwiya, kuda nkhawa, ataxia, kusintha kwa machitidwe, zotumphukira za m'mimba, nkhawa, kusokonezeka kwa kugona, kukhumudwa, kupweteka kwa mitsempha, kugwedezeka, kusokonezeka, kupsinjika, zosowa kwambiri: Hypersthesia, kusawona bwino, kununkhiza ndi tactile kudziwa, kuyerekezera zinthu.
Kuchokera ku genitourinary system:zosowa: interstitial nephritis, kuchuluka kwa serum creatinine ndende.
Kuchokera m'mimba ndi chiwindi: dysbiosis, kusintha kwa kukoma, stomatitis, glossitis, pafupipafupi: nseru, kutsegula m'mimba, kuchuluka kwa hepatic indices (ALT, AST, alkaline phosphatase, γ-glutamyltransferase), kuchuluka kwa bilirubin mu seramu yamagazi, zosowa: kusanza, dyspepsia, kupweteka kwa epigastric, hepatitis, cholestatic jaundice, zosowa kwambiri: pachimake chiwindi kulephera, kutsegula m'mimba ndi kuphatikizika kwa magazi, pseudomembranous colitis, mawonekedwe a lilime lakuda.
Kuchokera ku minculoskeletal system:zosowa: arthralgia, myalgia, matenda a tendon kuphatikizapo tendonitis, zosowa kwambiri: kupindika kwa tendon (kuthekera kwa maukwati ndi maola 48 atatha chithandizo), kufooka kwa minofu, rhabdomyolysis.
Pa khungu:pafupipafupi: pruritus, zotupa, zosowa: urticaria zosowa kwambiri: photosensitivity, kutupa kwa pakhungu ndi mucous nembanemba, zotupa zotupa za erythema (Stevens-Johnson syndrome), poyidermerm necrolysis (matenda a Lyell).
Kuchokera ku endocrine system:zosowa: kukomoka zosowa kwambiri: hypoglycemia, makamaka odwala matenda ashuga.
Kuchokera pakapumidwe:zosowa: bronchospasm, dyspnoea, zosowa kwambiri: chifuwa cha ziwindi.
Zambiri:zosowa: kufooka wamba zosowa kwambiri: malungo.
Zina: kupuma pang'ono, zosowa: kupatsirana kwakukulu (makamaka kwa odwala omwe ali ndi matenda osachiritsika kapena kuchepetsedwa kukana kwamthupi), kusintha kofanana ndi matenda a seramu milandu yokhayokha: anaphylactic mantha.

Bongo

Zizindikiro: nseru, kusanza, kutsegula m'mimba, kusowa kwa madzi mu electrolyte, nephrotoxicity, crystalloria, khunyu.
Chithandizo: kukhathamiritsa mafuta, magazi, kuwongolera madzi osakanikirana a electrolyte, hemodialysis ndikotheka.

Kuchita ndi mankhwala ena

Nthawi yochulukirapo yoyamwa digoxin pa mankhwala Amoxicillin Sandoz ®.
Khalid amachepetsa kuchulukitsidwa kwa amoxicillin ndi impso ndikuwonjezera kuchuluka kwa amoxicillin mu bile ndi magazi.
Kugwiritsa ntchito munthawi yomweyo amoxicillin ndi zina mankhwala a bacteriostatic (macrolides, tetracyclines, sulfonamides, chloramphenicol) chifukwa chakutsutsana. Ndi munthawi yomweyo aminoglycosides ndipo amoxicillin amatha kukhala ndi synergistic.
Kugwiritsa ntchito munthawi yomweyo amoxicillin ndi disulfiram.
Ndi munthawi yomweyo methotrexate ndi amoxicillin, kuchuluka kwa kawopsedwe wakale kumatha, mwina chifukwa cha mpikisano wa tubular aimpha secretion wa methotrexate ndi amoxicillin.
Maantacid, glucosamine, mankhwala ofewetsa thukuta, chakudya, aminoglycosides chepetsa ndikuchepetsa mayamwidwe, ascorbic acid kumawonjezera mayamwidwe a amoxicillin.
Zimawonjezera luso la zosadziwika anticoagulants (kupondereza microflora yamatumbo, kumachepetsa kapangidwe ka vitamini K ndi index ya prothrombin), kumachepetsa mphamvu estrogen okhala ndi pakamwa kulera, mankhwala omwe amapanga para-aminobenzoic acid (PABA), ethinyl estradiol - chiopsezo chakutuluka kwa magazi "
Ma diuretics, allopurinol, oxyphenbutazone, phenylbutazone, mankhwala osokoneza bongo omwe amaletsa kutupa ndi mankhwala ena omwe amatsekera katulutsidwe ka tubular, onjezani kuchuluka kwa amoxicillin m'magazi.
Allopurinol kumawonjezera chiopsezo chotenga chotupa cha pakhungu.

Malangizo apadera

Musanalembe Amoxicillin Sandoz ®, muyenera kuonetsetsa kuti zovuta zamagetsi zomwe zimayambitsa matenda opatsirana ndizomvera mankhwala.
Mokulira matenda opatsirana am'mimba komanso otupa a m'mimba, limodzi ndi matenda otsegula m'mimba kapena nseru, osavomerezeka amatenga Amoxicillin Sandoz ® mkatikati chifukwa cha kuchuluka kwa mankhwalawa.
Pochiza matenda othandizira kutsekula m'mimba ndi njira yothandizira, mankhwalawa othandizira odwala omwe amachepetsa matumbo amayenera kupewedwa, ndipo mankhwala a kaolin kapena a attapulgite okhala ndi antidiarrheal angagwiritsidwe ntchito. Kwa matenda otsegula m'mimba, funsani dokotala.
Ndi kukula kwambiri kutsegula m'mimba, kukula kwa pseudomembranous colitis (chifukwa Clostridium Hardile). Pankhaniyi, Amoxicillin Sandoz ® iyenera kusiyidwa ndipo chithandizo choyenera chikuyenera kutumizidwa. Nthawi yomweyo, mankhwala omwe amachepetsa mphamvu ya m'mimba amatsutsana.
Ndi njira ya chithandizo, ndikofunikira kuwunika momwe ntchito ya magazi, chiwindi ndi impso.
Ndikotheka kukhala ndi superinitness chifukwa cha kukula kwa microflora sazindikira izi, zomwe zimafunikira kusintha kofananirana ndi mankhwala opha maantibayotiki.
Odwala omwe ali ndi hypersensitivity ku penicillin, zovuta zomwe zimachitika ndi mankhwala ena a beta-lactam ndizotheka.
Kuchiza kumapitirirabe kwa maola ena 48-72 atatha kutha kwa zizindikiro za matenda.
Pogwiritsa ntchito nthawi yomweyo mankhwala okhala ndi pakamwa okhala ndi estrogen komanso amoxicillin, njira zina kapena zowonjezera zakulera ziyenera kugwiritsidwa ntchito ngati kuli kotheka.
Amoxicillin Sandoz ® simalimbikitsidwa pochiza matenda opatsirana oyambitsidwa ndi ma virus chifukwa chogwira ntchito pang'ono.
Chenjezo makamaka kwa odwala omwe ali ndi chifuwa chachikulu cha m'mimba kapena mphumu ya bronchial, mbiri ya matenda am'mimba (makamaka, colitis yomwe imayambitsidwa ndi mankhwala othandizira antiotic).
Pogwiritsa ntchito nthawi yayitali ya Amoxicillin Sandoz ®, nystatin, levorin, kapena mankhwala ena antifungal ayenera kuikidwa munthawi yomweyo.
Pa mankhwala, Mowa samalimbikitsa.
Kugwiritsa ntchito Amoxicillin Sandoz ® sikukhudza zotsatira za kusanthula kwa enzymatic kwa glucosuria, komabe, zotsatira zabwino za urinalysis zamatenda a shuga ndizotheka.
Mukumwa Amoxicillin Sandoz ®, tikulimbikitsidwa kuti mumwe madzi ambiri kuti muchepetse mapangidwe a makhwala a amoxicillin mkodzo.

Kukopa pa kuyendetsa magalimoto ndikuchita zina zomwe zimafuna kuyang'aniridwa ndi kuthamanga kwa zochitika zama psychomotor

Chifukwa cha zovuta zoyipa, monga kugona, kupweteka mutu komanso kusokonezeka, kusamala kuyenera kuchitidwa pochita zinthu zomwe zingakhale zoopsa zomwe zimafunikira chidwi chochulukirapo komanso kuthamanga kwa zochitika zama psychomotor.

Kapangidwe ka mapiritsi a Amoxicillin

Mankhwala othana ndi mankhwalawa amapangidwa mu Mlingo kuchokera pa 125 mg mpaka 1 gramu. Yogwira pophika mankhwala ndi dzina lomweli - amoxicillin mu mawonekedwe a trihydrate. Monga momwe othandizira amagwiritsidwa ntchito:

• magnesium wakuba,
• talcum ufa
• wowuma mbatata.

Makapisozi amkati mulinso zigawo zikuluzikulu za enteric-soluble.

Mankhwalawa ndi amisempha amodzi amtundu wa penicillin. Imagwira ntchito pothana ndi mabakiteriya opanda gramu komanso gramu, komanso ndodo zopanda gram. Yogwira ntchitoyo imathandizira kuletsa maselo a cell wall, potero kuletsa kuwonjezeka kwa magulu a tizilombo tating'onoting'ono.

Malangizo a mapiritsi Amoxicillin 250 mg

Mankhwala Amoxicillin 0,25 ga ndi mankhwala kwa ana ndi akulu omwe ndiofatsa kuti azichita bwino matendawa kwa masiku osachepera asanu. Kutalika kwakukulu kogwiritsira ntchito ndi masabata awiri.

Ndikofunika kumwa mankhwala maola 8 aliwonse musanadye:

• ½ mapiritsi - 2 years,
• piritsi lonse - kuyambira wazaka 5,
• Mapiritsi a 1-2 - kuchokera zaka 10 ndi akulu.

Zisonyezero zogwiritsidwa ntchito ndi zotupa za mabakiteriya am'munsi komanso m'munsi mwa kupuma:

• bronchitis
• tracheitis
• pharyngitis
• tonsillitis
• sinusitis
• sinusitis
• sepsis
• komanso matenda amtundu wa pakhungu ndi kapangidwe kanu ka khungu.

Malangizo a mapiritsi Amoxicillin 500 mg

Mankhwala Amoxicillin 0,5 g analengedwera akulu ndi ana opitirira zaka 10. Ndikofunikira kuti kulemera kwa thupi kupitirire 40 kg. Kutalika kwa chithandizo kumatsimikiziridwa payekhapayekha ndipo nthawi zambiri kumakhala masiku 7-10.

Pogwiritsa ntchito mankhwala kwa nthawi yayitali, komanso mankhwala ochepetsa mphamvu ya kachilomboka, tikulimbikitsidwa kumwa mankhwala antifungal.

Ndi zoletsedwa kwambiri kupitirira kuchuluka kwa zovomerezeka, chifukwa izi zimatha kubweretsa mavuto.

Malangizo ogwiritsira ntchito mapiritsi Amoxicillin 875 + 125

Kwa matenda ena, makapisozi a Amoxicillin okhala ndi Mlingo wa 875 + 125 amafunikira. Manambalawa akutanthauza kuti mu gawo limodzi la mankhwalawa muli 875 mg wa antibacterial chinthu ndi 125 mg wa chinthu chomwe chimachepetsa kukana kwa tizilombo. Nthawi zambiri, asidi wa clavulanic amakhala ngati choletsa. Zotsatira zake, mabakiteriya okhala ndi penicillinase-secreting sangathe kupirira ma antimicrobial wothandizirana nawo momwe angakhalire popanda choletsa.

Mankhwala amathandizidwa kuti azigwiritsa ntchito mitundu yoyenerera komanso yoopsa:

• kupuma dongosolo
• zotupa zam'mimba
• yotupa njira ya kwamikodzo dongosolo ndi ziwalo zoberekera.

Ana ochokera wazaka 12 ndi akulu omwe ndi omwe amapatsidwa kapisozi 1 (875 + 125) pachilichonse chovomerezeka. Tengani kawiri masana. Kutalika kwa mankhwala ndi masiku 5-14.

Malangizo a mapiritsi Amoxicillin 1000 mg

Mankhwala a antioxidillin a antioxicillin ndi mankhwala omwe amapezeka mu 1 gramu kwa odwala omwe ali ndi matenda oopsa a kupuma, urogenital thirakiti ndi khungu. Mankhwalawa angagwiritsidwe ntchito mwa ana omwe thupi lawo limaposa 40 kg, komanso kwa akulu:

• 1 piritsi 1,
• kutenga 2 pa tsiku pambuyo nthawi,
• Kutalika kwa ntchito ndi masabata 1-2.

Ndi typhoid fever, 1.5-2 g ya antibayotiki amatengedwa katatu patsiku. Pambuyo pa zovalazo, momwe zizindikiro za matendawa zimathera, mankhwalawa akupitiliza kwa masiku ena awiri.

Mapiritsi atatu a Amoxicillin - malangizo

Zochizira matenda a chinzonono, omwe amakhala osavuta kumva pachimake, antimicrobial wothandizidwa ndi 3 mg. Ndi milandu yokhayo pamene mlingo waukulu wa antibayotiki wapatsidwa mlingo umodzi.

Mankhwalawa gonorrhea ntchito:

• mwa amuna, makapisozi atatu a 1000 mg kamodzi,
• mwa akazi, 3 ga mankhwala kwa masiku awiri.

Pakuganiza kwa dokotala, Amoxicillin yokhala ndi antibayotiki amaphatikizidwa ndi chopinga chotengera phenenecid:

• musanayambe kumwa maantibayotiki, muyenera kumwa mankhwala a gout,
• Pakatha theka la ola, tengani mapiritsi atatu a Amoxicillin ndi 1 mg.

Malangizo ogwiritsira ntchito mapiritsi a Amoxicillin kwa akulu

Kwa odwala akuluakulu, mankhwalawa amapatsidwa mankhwala ochizira matenda opatsirana ndi kutupa:

• kugaya chakudya
• kwamikodzo dongosolo
• kumaliseche
• kupumira kwapansi,
• nasopharynx
• Ziwalo za ENT.

Kuchulukana kwa ntchito katatu patsiku. Mlingo umayikidwa payekha kuyambira 250 mpaka 1000 mg. Zowonetsa:

• otitis media: siteji yofatsa - 500 mg katatu patsiku, ndi kutupa kwambiri - 875 mg katatu patsiku maola 8 aliwonse masiku 5,
• sinusitis: 1500 mg imagawidwa pazigawo zitatu pafupipafupi kwa masiku 7,
• rhinopharyngitis: 500 mg katatu patsiku, nthawi ya mankhwala ndi masiku 7-14,
• tracheitis: 0,5 g katatu patsiku, ndimatenda akulu - 1 g katatu patsiku,
• bronchitisTengani kapisozi 1 (500 mg) katatu pakatha maola 8,
• pyelonephritis: 500 mg katatu pa tsiku, mu milandu yayikulu - 1000 mg katatu patsiku, njira ya mankhwalawa ndi masiku 7-10,
• cystitis: 250-500 mg mg ogaŵikana katatu, ndi matenda apamwamba - 1 g katatu patsiku.

Amoxicillin 250 - malangizo a mapiritsi a akulu

Makapisozi a Amoxicillin wokhala ndi muyeso wa 250 mg amaperekedwa kwa achikulire omwe ali ndi:

• matenda omwe samatsata ndi zovuta,
• mtundu wofatsa kapena wopatsa chidwi pamaphunziro popanda kuyembekezera kuwonongeka.

Malangizo ofunikira:

• Mankhwala amatengedwa mapiritsi 1-2 pa nthawi musanadye,
• pafupipafupi kugwiritsa ntchito katatu patsiku,
• gawo pakati Mlingo ndi 8 maola.

Amoxicillin 500 - malangizo a mapiritsi a akulu

Pa mlingo wa 500 mg, maantibayotiki amalembedwa kwa odwala akuluakulu ngati matendawa si ovuta ndipo amapezeka mwanjira yoyenera:

• Piritsi limodzi nthawi
• Masana, atatu amatengedwa nthawi yofanana,
• nthawi ya makonzedwe ndi masiku 5-14.

Mukatenga masiku opitilira 10, ndikofunikira kuwunika ntchito ya chiwindi ndi impso.

Mapiritsi a Amoxicillin 1000 - malangizo omwe angagwiritsidwe ntchito ndi akuluakulu

Mankhwala a 1000 mg a antibayotiki pochiza mu achikulire amapatsidwa mitundu yayikulu komanso yolimbitsa thupi:

• otitis
• purulent tonsillitis,
• pachimake pharyngitis
• pyelonephritis,
• cystitis
• matenda opatsirana pogonana
• matenda opatsirana pakhungu.

• Piritsi limodzi pa mlingo
• pafupipafupi ntchito 2 pa tsiku,
• nthawi pakati Mlingo ayenera kukhala ndendende maola 12,
• Kutalika kwa chithandizo ndi masiku 5-10.

Mlingo wambiri wa mankhwalawa ungakhudze chiwindi ndi impso; kuwunika momwe ntchito yawo imalimbikitsidwira.

Malangizo a mapiritsi a Amoxicillin a ana

Amoxicillin wa ana ndi antibacterial wothandizila wa gulu la penicillin. Mu ana aang'ono, mankhwalawa amatha kuyambitsa matenda a hypersensitivity, chifukwa chake, amaikidwa mosamala komanso moyang'aniridwa ndi dokotala.

Mlingo wa Amoxicillin wa ana umayikidwa payekhapayekha:

• wakhanda ndi ana a chaka choyamba cha moyo malinga ndi zaka 20-25 mg pa kilogalamu,
• kuyambira 2 mpaka 125 mg,
• kuyambira zaka 5 mpaka 250 mg,
• kuyambira zaka 10 mpaka 500 mg.

Kutengera ndi anamnesis ndi mbiri yojambulidwa, ana amapatsidwa mlingo wofanana wa 125-500 mg kuti agwiritse ntchito kamodzi. Pafupipafupi kugwiritsa ntchito ndi 2-3, ndipo nthawi yake ndi masiku 5-7. Ndi bwino kupereka mankhwala kumayambiriro kwa chakudya. Izi zikuthandizira kuchepa kwamatumbo komwe kumachitika kawirikawiri kwa ana mukamagwiritsa ntchito mankhwala osokoneza bongo.

• pachimake ndi otitis media,
• pharyngitis ndi rhinopharyngitis,
• bronchitis
• matumbo ndi adenoiditis,
• cystitis ndi pyelonephritis,
• matenda a purulent a minofu yofewa.

Mapiritsi a Amoxicillin 250 - malangizo a ana

Chovomerezeka kugwiritsa ntchito mankhwala omwe ali ndi Mlingo wa 250 mg wa ana azaka ziwiri.

Mlingowu umalola kugwiritsa ntchito mankhwala ngati makapisozi. Ngati mwana sangathe kumeza lonse, mutha kutsegula chigobacho, kutsanulira ufa ndi kusungunuka m'madzi a 5-10 ml.

Malangizo ogwiritsira ntchito mapiritsi a Amoxicillin kwa amayi apakati

Malinga ndi chidziwitso kuchokera ku malangizo ogwiritsira ntchito, mankhwalawa amatha kutumizidwa kuti azimayi omwe akuyembekezera ngati akuwonetsa zina:

• chinzonono
• matenda amitsempha
• cystitis
• pyelonephritis,
• chapamwamba kupuma thirakiti matenda ndi mawonekedwe a catarrhal mu mawonekedwe a chifuwa, mphuno,
• bronchitis
• tracheitis.

Kafukufuku awonetsa kuti maantibayotiki samayambitsa masinthidwe ndipo sangathe kusokoneza chitukuko cha embryonic.

Pa mimba, osachepera ogwira Mlingo wa mankhwala zotchulidwa - kuchokera 250 mg katatu patsiku. Nthawi yochepa yogwiritsira ntchito ndi masiku 5-7. Komabe, adokotala amatha kusintha njira komanso njira zamankhwala mogwirizana ndi matendawo.

Amoxicillin - analogi - malangizo ntchito

Kutengera ndi zomwe zimagwiritsidwa ntchito, ma antibacterial othana ndi omwe amapezeka. Zizindikiro zogwiritsidwa ntchito ndi iwo zimasinthasintha. Mu malangizo ogwiritsira ntchito mankhwala ena mumasiyana mu regimen ndi contraindication.

Flemoxin Solutab

Amagwiritsidwa ntchito mwachangu mu ana, popeza mapiritsi samasungunuka mosavuta m'madzi. Amapezeka mu Mlingo wa 125, 250, 500 ndi 1000 mg. Amoxicillin, cellulose omwazika, zonunkhira ndi zotsekemera zilipo.

Kulephera kwamkati kumawonjezera pamndandanda wokhazikika wa zotsutsana. Mankhwala amagwiritsidwa ntchito ana kuyambira kubadwa, ndipo mlingo umawerengeredwa ndi kulemera kwa thupi:

• M'miyezi 12 yoyambirira, 30-60 mg patsiku,
• kuyambira zaka zitatu mpaka 375 mg kawiri,
• kuchokera zaka 10 750 mg kawiri kapena 500 katatu.

Mtengo Flemoxin Solutab:

• 125 mg - 230 rub.,
• 500 ndi 250 mg - 260 ma ruble.,
• 1000 mg - 450 ma ruble.

Mankhwala amapezeka mu Mlingo wa 250, 500 ndi 1000 mg. Mankhwala ndi contraindised mu:

• khunyu
• matupi awo sagwirizana
• hay fever
• matenda mononucleosis,
• kupuma matenda
• matenda am'mimba, omwe mumatsuka, m'mimba mumadziwika.

Ospamox amatengedwa pakamwa yonse, kutsukidwa ndi madzi. Mankhwala amagwiritsidwa ntchito mulingo wotsatira:

• mwa ana osakwana zaka 10 zakubadwa mwa mawonekedwe a kuyimitsidwa, mapiritsi sayikidwa,
• kuyambira zaka 10 mpaka 0,5 g m'mawa ndi madzulo,
• kuyambira wazaka 16 mpaka 750 mg kawiri,
• akuluakulu, 1 g m'mawa ndi madzulo.

Mtengo wa mankhwalawa mosiyanasiyana uli pamtunda kuchokera 30 mpaka 150 ma ruble.

Wopezeka mu Mlingo wa 250 ndi 500 mg, akulimbikitsidwa pochiza matenda oyambitsidwa ndi bakiteriya malinga ndi chiwembu:

• 125 mg - patatha zaka ziwiri,
• 250 mg - patatha zaka 5,
• 250-500 mg - patatha zaka 10,
• kwa akulu ndi achinyamata azaka 18, 500 mg katatu kapena 1000 mg kawiri.

Osati kwa akazi apakati.

Mtengo wa mankhwalawa ndi ma ruble 30. kwa 250 mg ndi 60 ma ruble. kwa 500 mg.

Kuphatikiza pa chinthu chachikulu yogwira mu 250 ndi 500 mg, imakhala ndi lactulose, povidone, wowuma wa mbatata, talc. Osasankhidwa kwa ana osakwana zaka zitatu. Chalangizidwa kuti mugwiritse ntchito:

• Akuluakulu 500-1000 mg,
• kwa achinyamata 500-750 mg,
• ana ochokera zaka 3 zakubadwa 125-250 mg.

• 250 mg - 60 ma ruble.,
• 500 mg - 130 ma ruble.

Mtengo wa mapiritsi a Amoxicillin

Kutengera ndi kuchuluka kwake, kuchuluka kwa mapiritsi ndi wopanga, mtengo wa mankhwala a Amoxicillin umasintha:

• Hemofarm 16 zidutswa 500 mg - 90 ma ruble.,
• Hemofarm 16 makapisozi a 250 mg - 58 ma ruble.,
• Sandoz 12 zidutswa za 1000 mg - 165 ma ruble,
• Avva Rus 20 mapiritsi a 500 mg - 85 ma ruble.

Mtengo wa mankhwalawa 500 mg umasiyana m'mafakitore ena apakompyuta:

Momwe mungagwiritsire ntchito: Mlingo ndi njira ya chithandizo

Amapangidwa kuti azikulankhula pakamwa.

Monga lamulo, chithandizo chamankhwala chikulimbikitsidwa kupitiliza kwa masiku awiri atatha kutha kwa zizindikiro za matendawa. Pankhani ya matenda obwera chifukwa cha D-hemolytic streptococcus, kuthetseratu kwathunthu kwa pathogen kumafunika chithandizo kwa masiku osachepera 10.

Paresteral chithandizo akuwonetsedwa chifukwa cha kuthekera kwa makonzedwe apakamwa komanso kuchiza matenda oopsa.

Mlingo wa akulu (kuphatikizapo odwala okalamba):

Mulingo wamba umachokera ku 750 mg mpaka 3 g ya mankhwala patsiku zingapo. Nthawi zina, tikulimbikitsidwa kuti muchepetse mlingo wa 1500 mg wa tsiku patsiku zingapo.

Njira yochepa yothandizira:

Osavuta kwamikodzo thirakiti matenda: kumwa 2 ga mankhwalawa kawiri pa jekeseni iliyonse ndi gawo pakati pakati Mlingo wa maola 10-12.

Mlingo wa ana (mpaka zaka 12):

Mlingo wa tsiku ndi tsiku wa ana ndi 25-50 mg / kg / tsiku zingapo.

Ana osaposa 40 makilogalamu ayenera kulandira munthu wamkulu.

Mlingo wa kulephera kwa impso:

Odwala omwe ali ndi vuto lalikulu la impso, mlingo uyenera kuchepetsedwa. Ndi chilolezo chokhala ndi impso zosakwana 30 ml / min, kuwonjezeka kwakanthawi pakati pa Mlingo kapena kuchepa kwa Mlingo wotsatira tikulimbikitsidwa. Mu kulephera kwa aimpso, maphunziro ochepa a 3 g amatsutsana.

Akuluakulu (kuphatikiza odwala okalamba):

Kulengedwa kwa Creatinine> 30 ml / mphindi - palibe kusintha kwa mlingo kofunikira

Kupita kwa creatinine 10-30 ml / mphindi - 500 mg maola 12 aliwonse,

Kutenga kwa creatinine 30 ml / mphindi - palibe kusintha kwa mlingo kofunikira

Kupita kwa creatinine 10-30 ml / mphindi - 15 mg / kg maola 12 aliwonse,