Gabapentin: mawonekedwe ndi kugwiritsa ntchito mankhwalawa ngati mankhwala

ntchito yogwira : gabapentin,

1 kapisozi yokhala ndi 300 mg ya gabapentin malinga ndi 100% yamadzimadzi,

Othandizira: cellcrystalline cellulose, wowuma chimanga, talc

kapisozi kapangidwe: gelatin, titanium dioxide (E 171).

Zolemba za Gabapentin

Posachedwa, mankhwala a Gabapentin ali ndi chidwi monga njira yomwe imagwiritsidwa ntchito pazochita zamankhwala. Poyamba, adalembetsa ngati antiepileptic mankhwala.

Mankhwala omwe amapangira mankhwala ndi a gabapentin

Pambuyo pake, adazindikira kuthekera kwa mankhwalawa kuti athetse kupweteka kwa mitsempha ya neuropathic panthawi ya postherpetic neuralgia, polio neuropathy, komanso Reflex yachifundo.

Kafukufuku yemwe adachitika pambuyo pake adatsimikizira kupezeka kwa opweteka pamankhwala osokoneza bongo, omwe amawonetseredwa mu matenda a shuga a neuropathy komanso amamvera tsitsi la Reflex. Chofunika kwambiri ndikugwiritsa ntchito mankhwala a Gabapentin kuti athetse ululu wammbuyo wamitsempha yama mitsempha yambiri.

Kapangidwe ndi mawonekedwe

Dzinali limatchedwa Gabapentin, kapangidwe kake ka mankhwalawa ndi gabapentin 300 mg, magawo ena owonjezera ndi calcium stearate, sodium carboxymethyl starch, microcrystalline cellulose. The kapisozi ndi titanium dioxide ndi gelatin.

Mankhwala amamasulidwa monga mapiritsi kapena mapiritsi. Makapisozi amatha kukhala oyera, achikasu kapena obiriwira, kutengera wopanga.

Fomu lotulutsira kapepaloti wa Gabapentin

Makapisozi a gelatin amakhala ndi ufa wa chikaso chopepuka kapena choyera. Ufawo ndi wokhazikika bwino, mapangidwe ang'onoang'ono, omwe, atapanikizidwa ndi spatula yagalasi, atha kubalalika, amavomerezeka.

Mapiritsi a Gabapentin amapezeka kokha mwa mankhwala. Mfundo yeniyeni ya mankhwalawa idakali funso.

Kapangidwe ka Gabapentin mu kapangidwe kake kama mankhwala ndi ofanana ndi GABA. Komabe, salowa polumikizana ndi GABA agonists ndi GABA receptors. Kuchita kwa chinthu kumachitika ndi ma receptor atsopano omwe amasewera gawo la kulumikizana mu cortical neurons.

Pa maphunziro omwe amapangidwa pa makoswe, adazindikira kukhalapo kwa zigawo zomanga thupi zamapuloteni, zomwe zimawonetsa ntchito ya analgesic ndi anticonvulsant ya chinthu chomwe ndi zomwe zimachokera. Mphamvu ya anticonvulsant imadziwika, momwe mungathetsere kupweteka kwa chikhalidwe cha neuropathic pamunsi komanso chapakati.

Kuchulukitsa kaphatikizidwe ka GABA m'chigawo chapakati chamanjenje ndi Gabapentin

The analgesic ndi anticonvulsant zotsatira za mankhwala n`zotheka chifukwa kuthetsedwa glutamate-amadalira kufa maselo a gulu la neuronal, poletsa kaphatikizidwe wa glutamate. Gabapentin amatha kuwonjezera kaphatikizidwe ka gamma-aminobutyric acid pakatikati wamanjenje.

Nthawi yomweyo, mothandizidwa ndi mankhwalawa, kumasulidwa kwa ma neurotransmitters okondweretsa amakakamizidwa. Kupweteka kwa Neuropathic kumatsitsimuka ndikumangidwa kwa njira za calcium.

Chifukwa cha kuyanjana uku, kuchuluka kwa calcium komwe kumalowa m'maselo kumatsika, ndipo PD ya nembanemba yamitsempha yama minyewa imachepa. Mothandizidwa ndi Gabapentin, kuchuluka kwa GABA mu cytoplasm ya neurons kumawonjezera, serotonin ya plasma imakulanso. Pa kagayidwe, mankhwalawa amachotsedwa m'thupi ndi hemodialysis, kudzera mu impso.

Chizindikiro chovomerezeka

Mu malangizo ogwiritsira ntchito Gabapentin, zambiri zotere zimasonyezedwa:

1. vuto la neuropathic ululu womwe umachitika mwa achikulire wazaka zopitilira 18 (palibe zomwe zingagwiritsidwe ntchito popanda vuto mpaka pano),
2. kugwidwa mwachangu ndi kapena kusagawanidwanso, kuyambira muli ndi zaka 12 (palibe chidziwitso chogwiritsa ntchito mpaka zaka 12).

Mankhwalawa amadziwikanso ngati gawo lovuta pa mankhwalawa akamakhudzidwa pang'ono popanda kukhudzika komanso kuthandizira kwachiwiri kwa ana azaka zitatu ndi akulu.

Kugwiritsa ntchito gabapentin kuti muchepetse kupweteka kwa neuropathic

Mpaka zaka zitatu, nkovuta kuweruza kugwiritsa ntchito mankhwalawa - palibe chidziwitso pakugwiritsa ntchito kwake otetezeka komanso othandiza kwa odwala.

Contraindication

Gabapentin adayikidwa mu:

• ndi zotsatira zoyipa za thupi kupita ku chinthu chofunikira kapena zinthu zothandiza popanga chipangizo chachipatala,
• pa mimba ndi kuyamwa,
• muubwana (mpaka zaka 8).

Zakudya za Gabapentin sizimayima panokha nthawi yazakudya. Mapiritsi kapena makapisozi amasambitsidwa pansi ndi madzi okwanira.

Kwa achinyamata ndi akulu pa matenda a khunyu, 300 mg ya mankhwala ndi mankhwala. Tsiku lililonse, mlingo wa Gabapentin umachulukitsidwa ndi 300 mg mpaka mphamvu yomwe mukufuna itakwaniritsidwa. Wapakati ogwira ntchito tsiku ndi tsiku ndi 1800 mg, kwa ena odwala akhoza kukhala 3600 mg.

Panthawi ya odwala omwe ali ndi zaka 8 mpaka 12, kuchuluka kwa mankhwalawa amawerengedwa potengera kulemera kwa thupi - 10-15 mg / kg / tsiku. M'masiku atatu otsatira, mankhwalawa amasinthidwa kukhala 30 mg, ogawidwa magawo atatu patsiku.

Palinso dongosolo lina logwiritsira ntchito mankhwalawa:

1. kulemera kwa thupi 26-25 kg - 900 mg,
2. 37-50 kg - 1200 mg,
3. zoposa 50 kg - 1800 mg.

Chithandizo cha kupweteka kwa mitsempha ya neuropathic imaphatikizapo kugwiritsa ntchito mlingo wochepa wa 300 mg patsiku, ndikuwonjezeka kwa yunifolomu mpaka 1800 mg. Izi zikuyenera kugawidwa m'magawo atatu.

Kutenga 300 mg ya gabapentin patsiku kwa ululu wa neuropathic

300-400 mg kumayambiriro kwa mankhwalawa amaperekedwa kwa odwala omwe amafunikira hemodialysis nthawi zonse. Cholinga ndikukwaniritsa thupi ndi mankhwala.

Pambuyo pake, gawo la maola 4 limapitilirabe kutenga 200-300 mg. Mlingo wa tsiku ndi tsiku wa mankhwala omwe ali ndi odwala omwe ali ndi zovuta mu dongosolo la ma excretory zimatengera mulingo wa QC.

Bongo

Ngati mukuganiza kuti mungamwe mankhwala ochuluka, kugona, diplopia, dysarthria, chizungulire chimachitika. Nthawi zina, kusokonezeka kwa chikumbumtima.

Kugona chifukwa cha mankhwala osokoneza bongo a Gabapentin

Malinga ndi malangizo, mankhwalawa sayenera kuyambitsa zizindikiro za kusiya. Ndemanga za odwala za Gabapentin zikuwonetsa kuti nthawi zina panali kuwonongeka m'moyo wina atatha kusiya ntchito.

Mu pharmacology, mankhwala ena amapangidwa, Gabapentin analogues - Tebantin, Konvalis, Neurontin, Gapentek, Lepsitin.

Mndandanda wa mankhwala Gabapentin

Chodziwika mu mankhwalawa ndimakhala kuti ali ndi gabapentin.

Mankhwala kapena ayi

Othandizira ena a Gabapentin ndi amodzi mwa mankhwalawa omwe amayambitsa kudalira kwa psychophysiological. Anthu ambiri amaganiza kuti gabapentin ndi mankhwala osokoneza bongo.

Pakati pa akatswiri, pali malingaliro okhudzana ndi zoopsa za mankhwalawa - zimatha kuwonetsa kwambiri kukhumudwa komanso kukhudza mawonekedwe a malingaliro ofuna kudzipha. Malangizo akufotokozerani zoopsa zonse zomwe zingatheke, chifukwa chake sayenera kugwiritsa ntchito mankhwalawo pawokha.

Kuopsa kogwiritsa ntchito mankhwalawa kuli pachiwopsezo cha chiwonetsero cha kusiyanasiyana. Izi zikuwonetsa kukhudzika kwake komanso kuwononga kwake thupi. Kumbukirani kuti mankhwala aliwonse omwe amaphatikizapo gabapentin ayenera kutumizidwa ndi dokotala waluso komanso wodziwa ntchito.

Katswiriyu amasanthula kaye za mbiri ya wodwalayo, ndipo amangoganiza zokhazo. Kupanda kutero, wodwalayo akhoza kukhala kuti wachita mantha, wolankhula komanso safuna kudzipha.

Kuchiza ndi mankhwalawa chifukwa chomwa mowa kapena osokoneza bongo sikuyenerera - motsutsana ndi zomwe zidayamba kale, munthu atha kukhala watsopano. Mwa mawonekedwe aliwonse owonetsa zovuta, muyenera kufunsa chithandizo kuchokera kwa dokotala.

Gulu la mankhwala

Khodi ya PBX N03A X12.

Khunyu Monga monotherapy zochizira kugwidwa motsimikiza kapena popanda yachiwiri generalization mu akulu ndi ana azaka 12 zakubadwa.

Monga njira yowonjezerapo mankhwalawa pakukakamiza pang'ono kapena mwachisawawa kwa akulu ndi ana azaka 6.

Chithandizo cha zotumphukira za m'mitsempha ya mitsempha yokhala ndi netigia ya postherpetic kapena neuralgia ya akuluakulu.

Mlingo ndi makonzedwe

Mkati, ngakhale chakudyacho, muli madzi ambiri.

Kumayambiriro kwenikweni kwa chithandizo, chiwembu chokhazikitsidwa chomwe chikuwonetsedwa mu Gawo 1 chikulimbikitsidwa kwa akulu ndi ana opitirira zaka 12

Odwala omwe ali ndi khunyu amafunikira chithandizo chautali. Mlingo umakhazikitsidwa molingana ndi kulolerana komanso kugwiritsa ntchito mankhwalawa. Malinga ndi adotolo, pakufunika kuchepetsa mlingo, kusiya kumwa mankhwalawo kapena kuthandizanso ndi munthu wina, izi ziyenera kuchitika pang'onopang'ono kwa sabata limodzi.

Akuluakulu ndi ana opitilira zaka 12.

Mlingo wothandizila wa Gabantin ndi 900-3600 mg patsiku (wogawidwa pazigawo zitatu).

Kuchiza kungayambike ndi gawo limodzi la mankhwalawa, monga momwe tafotokozera 1, kapena 300 mg malinga ndi katatu patsiku 1. M'tsogolomo, kutengera momwe wodwalayo amayankhira chithandizo ndi kulolera kwa mankhwalawa, mlingo umatha kuwonjezeka pang'onopang'ono ndi 300 mg tsiku lililonse tsiku lililonse la 2-3 mpaka mlingo waukulu wa 3600 mg tsiku lililonse. Kwa odwala ena, mlingo wochepetsetsa wa titapentin ungafunike. Nthawi yocheperako isanafike mlingo wa 1800 mg wa tsiku lililonse imafanana ndi sabata limodzi, Mlingo wa 2400 mg wa tsiku - masabata awiri, waukulu wa 3600 mg tsiku - pafupifupi masabata atatu. Kutalika kwakukulu pakati Mlingo wa mankhwala sayenera kupitirira 12:00 kuteteza kukula kwa khunyu.

Ana a zaka zapakati pa 6 mpaka 12.

Chithandizo chimayamba ndi mlingo wa 10-15 mg / kg / tsiku. Mlingo wogwira ndi 25-35 mg / kg / tsiku, womwe umatheka ndi masiku atatu. Mlingo wa tsiku ndi tsiku umagawidwa katatu, Mlingo wapakati pakati pa mankhwalawa sayenera kupitirira 12:00.

Kupweteka kwamitsempha m'mimba mwa akulu.

Chithandizo chingayambitsidwe mwa kutumikiridwa ndi mankhwalawo, monga momwe tafotokozera 1, kapena pofotokoza koyamba ka 900 mg patsiku, logawidwa pazigawo zitatu. M'tsogolomo, kutengera momwe wodwalayo amayankhira chithandizo ndi kulolera kwa mankhwalawa, mlingo umatha kuwonjezeka pang'onopang'ono ndi 300 mg tsiku lililonse tsiku lililonse la 2-3 mpaka mlingo waukulu wa 3600 mg tsiku lililonse.

Kwa odwala ena, mlingo wochepetsetsa wa titapentin ungafunike. Nthawi yocheperako yofika mlingo wa 1800 mg tsiku limafanana ndi sabata limodzi, Mlingo wa 2400 mg tsiku - amatenga masabata awiri, waukulu wa 3600 mg tsiku - avareji ya masabata atatu. Kutalika kwapakati pakati Mlingo wa mankhwala sayenera kupitirira 12:00.

Chitetezo cha mankhwala opitilira miyezi yoposa 5 pochizira zowawa za neuropathic sichinaphunzire. Ngati mukufunika kugwiritsa ntchito gabapentin pochizira zowawa za m'mitsempha yopitilira miyezi isanu, dokotala amayenera kuwunika wodwalayo ndikuwonetsa kufunika kwa chithandizo chowonjezera.

Ngati mukuphonya mlingo wotsatira wa mankhwalawo, muyenera kumwa mankhwalawo omwe mwaphonya, malinga ndi momwe mlingo wotsatira ulandililidwe osalandilidwa kuposa 4:00. Kupanda kutero, mlingo womwe wakuphayo suyenera kumwedwa.

Kwa odwala omwe ali ndi vuto lofooka mthupi, atachepetsa thupi, kufalikira kwa gawo, mlingo wa gabapentin uyenera kupatsidwa gawo pang'onopang'ono pogwiritsa ntchito mlingo ndi kuchuluka kwa mankhwalawa kapena kuwonjezera kuchuluka pakati pakulimbitsa.

Okalamba okalamba (woposa zaka 65).

Kwa odwala okalamba, kusintha kwa mankhwalawa kungafunike chifukwa cha kuchepa kwa zaka ndi ntchito ya impso (onani Gome 2).

Odwala ndi mkhutu aimpso ntchito.

Odwala omwe ali ndi vuto la impso kapena omwe ali ndi hemodialysis, kusintha kwa mlingo kumalimbikitsidwa monga momwe tafotokozera mu tebulo lachiwiri.

Gulu lazachipatala, INN, kuchuluka

Gabapentin ndi wa gulu la mankhwala opha anticonvulsants ndi antiepileptic mankhwala. Dzinalo losavomerezeka la padziko lonse la mankhwalawa (INN) ndi Gabapentin.

Mankhwalawa amagwiritsidwa ntchito pazamankhwala osiyanasiyana:

• mu neurology zochizira khunyu ndi kupweteka matenda mu akulu ndi ana,
• Mankhwalawa ndi dermatovenerology yochotsa zowawa ndi kupindika komanso kupweteka kwamizu.

Mafomu ndi mitengo yake

Makapisozi a Gabapentin amapezeka m'matumba a zidutswa 10 mpaka 100. Kunja, makapisozi amatha kukhala ndi utoto wochokera kwa oyera-achikasu mpaka obiriwira, mkati mwa ufa ndi zoyera.

Mtengo wa gabapentin umasiyana malinga ndi kuchuluka kwa mapiritsi omwe ali phukusi.

Zigawo

Kapangidwe ka mankhwala kamaphatikizira zinthu zomwe zimagwira ndi zina zothandiza:

Pharmacodynamics ndi pharmacokinetics

Gabapentin ndi analogue ya neurotransmitter inhibitor gamma-aminobutyric acid, momwe ntchito imafanana ndi tranquilizer ndi antipsychotic mankhwala, koma magwiritsidwe ake ndi osiyana. Zomwe zimagwiritsidwa ntchito sizikhudza kuthana ndi zolandilira zomwe zimakhudzidwa ndi GABA. Zotsatira zazikulu zamankhwala zimachitika chifukwa chakuti gabapentin imamangilira njira zama calcium zomwe zimadalira magetsi ndipo zimalepheretsa kulowa mkati mwa calcium ions ndi blockade ya ululu.

Limagwirira ntchito a Gabapentin

Gabapentin amalowa momasuka mu minofu ya mu ubongo ndikulepheretsa zochitika zogwira mtima, kulepheretsa kukula kwa kumwa kwa mankhwalawa komanso magetsi amagetsi kuchokera kunja, cholowa chamilandu, chikafinyidwa ndi zotupa zamkati. Nthawi yomweyo, maginidwe anticonvulsant zotsatira sanawerengetse bwino, omwe amachepetsa kwambiri kuwonetsa kwa mankhwala.

The bioavailability of the yogwira mankhwala ndi 60%, njira yolumikizirana ndi mapuloteni amadzi am'magazi ndi ochepera 3%, koma bioavailability siyokhudzana ndi mlingo, popeza ndi kuwonjezeka kwa chinthu, ntchito ya Gabapentin imachepa.

Ndi pakumwa pakamwa, kuchuluka kwakukulu kwa mankhwalawa kumatsimikiziridwa mu plasma pambuyo maola awiri kapena atatu, ndipo theka la moyo ndi maola 5-7. Amakungidwa ndi mkodzo wokha, pomwe sikukonzedwa mthupi la munthu ndipo satenga nawo mbali m'magulu a oxidative, kusintha ndi kusefera kwa chiwindi sikuchitika.

Momwe mungasinthire mankhwalawo?

Muzipatala, fanizo la mankhwala limaperekedwa, lomwe limaphatikizanso gawo limodzi lofanana, komanso mankhwala omwe ali ndi mfundo zofananira. Amasiyana mu mtengo ndi mawonekedwe omasulidwa.

Zizindikiro ndi malire

Kodi chimathandiza ndi chiyani? Ndikofunikira kumvetsetsa bwino zomwe zimachitika ndi mankhwalawo ndikuwona momwe zingagwiritsire ntchito mankhwalawa:

• ntchito ngati monotherapy odwala opitirira zaka 12, pamaso pa kugwidwa pang'ono, komanso concomitant generalization matenda.
• kupweteka kwa neuropathic mwa akulu
• mankhwala osokoneza bongo a khunyu,
• Kuchotsa ululu pambuyo mavuto shingles.

Mankhwalawa ali ndi contraindication okhazikika, okhudzana ndi zida zamphamvu, ndipo amagwiritsidwa ntchito mosamala ngati akuphwanya ziwalo zamkati, matenda amitsempha yama cell.

Mwa zina zoletsa kumwa mankhwalawa, ndikofunikira kuwunikira:

• kusalolera payekha ndi hypersensitivity pazinthu zomwe zimapanga mankhwala,
• pachimake yotupa njira mu thupi kugwirizana ndi kuvulala kwa endocrine tiziwalo totupa, matenda a chithokomiro England, pancreatic necrosis, matenda a adrenal cortex),
• kuwonongeka kwa chiwindi ndi mavairasi, matenda am'mitsempha am'mimba (cirrhosis, chiwindi, hepatitis B ndi C),
• kwambiri kulephera kwa aimpso, komanso kuchita njira yochita kusefa - hemodialysis,
• nthawi ya pakati, popeza palibe umboni pazotsatira za mwana wosabadwayo. Mnthawi yomwe maubwino okhudzana ndi thanzi ndi moyo wa mayi ataposa chiwopsezo chovulaza mwana wosabadwa, Gabapentin adayikidwa pambuyo poyankhulana ndi dokotala yemwe amachititsa kuti mayiyo akhale ndi pakati.
• nthawi yoyamwitsa, popeza palibe deta pamakina owonekera kwa mwana. Mukamaphunzira mankhwalawa, zidatsimikizika kuti zinthu zomwe zimagwira zimalowa momasuka mkaka wa m'mawere.
• anthu ochepera zaka 12 zanthawi yochizira matenda opatsirana,
• kupweteka kudera lumbar pambuyo kuphulika kwa herpetic kwa shingles wazaka zosakwana 18.

Mlingo wa akulu ndi ana

Ndondomeko ya mlingo wake imadalira zomwe zimayambitsa chidwi komanso mawonekedwe a matenda. Mfundo zoyambira kuwerengera mulingo zimasonyezedwa patebulopo.

Mankhwala sinafike kwa ana osaposa zaka 12 ndi kukomoka, mankhwala oyamba a mwana samasiyana ndi omwe akulu - 900 mg mu Mlingo utatu wogawanika, koma kuchuluka kwake - 2400 mg mu Mlingo atatu wogawanika (3600 mg pambuyo pa zaka 18).

Zochizira zakumwa zoledzeretsa

Kafukufuku wokhala ndi gulu lowongolera adawonetsa kuti odwala omwe adachita chithandizo chamankhwala kwa miyezi itatu kuti athandize kudalira mowa adazindikira kuchepa kolakalaka zakumwa zoledzeretsa komanso kukhazikika kwa mkhalidwe wawo wamaganizidwe (kumwa muyezo wa 300 mg katatu patsiku).

Ndi kuwonjezeka kwa mlingo mpaka 600 mg katatu patsiku, sikuti kunangokhala kusowa kwa mowa, komanso kunjenjemera kugona, 46% kusiyiratu kumwa, ndipo mkhalidwe wamalingaliro unasintha ndi 15% (kuchepa kwa nkhawa, kusakwiya, kupsa mtima).

Gebapentin amathandizira kuthana ndi uchidakwa.

Momwe mungachotsere mankhwalawo?

Mankhwala amaletsedwa mwadzidzidzi kuletsa, mawonekedwe a matenda amkati mwa mitsempha amakhala ndi mawonekedwe - kuyambira kuda nkhawa, kupsa mtima, kusinthasintha, kusowa tulo mpaka maonekedwe a kuyerekezera zinthu zina komanso kukula kwa mawonekedwe a khunyu.

Njira yabwino kwambiri yothetsera vutoli ndikuchepa kwapang'onopang'ono kwa masiku opitilira 7-10, pamlingo waukulu komanso kugwiritsa ntchito nthawi yayitali kwa zaka zingapo, njira yolembetsa imatha kukhala miyezi ingapo mpaka kaphatikizidwe kadzathe.

Zotheka zoyipa ndi bongo

Ngati kuphwanya mlingo regimen, mankhwala, kusalolera mankhwala ndi zigawo zikuluzikulu, zimachitika zosiyanasiyana zamkati mwa thupi zitha kuchitika:

Mankhwala osokoneza bongo amawonetsedwa pamene mlingo woyenera wonjezedwa ndikuwonetsedwa ndi chithunzi chotsatira cha matenda:

• chikomacho,
• masomphenya apawiri
• zam'mimba thirakiti (kusanza, kutsegula m'mimba),
• Zizindikiro zamitsempha m'mimba (kugona, kuyerekezera zinthu zina, kusokonekera, kupindika, chikomokere),
• kusokoneza malo ndi nthawi.

Chithandizo chimayamba ndi kupweteka kwam'mimba komanso kupumula kwa matendawa, mitundu yeniyeni yotsalira ilibe. Wodwalayo amatumizidwa kuchipatala kuti akonze zomwe zikuwoneka ndikuwunika momwe thanzi liliri.

Kodi ili ndi vuto lililonse?

Mankhwalawa samatulutsa mankhusu, chifukwa momwe limagwirira ntchito pa thupi ndizosiyana ndi zolimbikitsa za opioid receptors. Sichimabweretsa chisangalalo, koma chimatulutsa zotsatira za analgesic.

Chomwe chimasiyanitsa ndi Gabapentin ndikuti ndi kuchuluka kwa mankhwalawa, zotsatira zake, m'malo mwake, zimachepa.

Kuchita ndi mankhwala ena

Mankhwala ayenera kugwiritsidwa ntchito mosamala ndi mankhwala ena ndikuwonetsetsa zomwe zikuchitika:

1. Morphine ndi narcotic analgesics - samakhudzana wina ndi mnzake, osatenga mbali popanda choletsa kapena kukulitsa mphamvu ya kugwiritsa ntchito mankhwala awiri amodzi.
2. Kuvomerezedwa ndi ma antacid amalepheretsa kupezeka kwa Gabapentin ndi 15-30%.
3. Kutsika kwa impso excretion ya mankhwalawa kumawonedwa pakuphatikizidwa ndi mankhwala omwe amaphatikiza cimetidine.

Malangizo apadera

Gwiritsani ntchito mosamala pamaso pa njira yotupa m'matumbo, ndimomwe zimayambitsa kupweteka kwam'mimba, ndikofunikira kusiya pang'onopang'ono mankhwala kuti mupewe kuwonjezeka kwa vutolo.

Gabapentin sagwiritsidwa ntchito pochiza matenda a khunyu. Panthawi yamankhwala, zochita zina ziyenera kupewedwa: magalimoto oyendetsa, makamaka akamagwira ntchito ndi zoyendera zamagulu onse, ndikuchepetsa ntchitoyi ndi zinthu zomwe zingayake ndikuwonetsetsa kuti pakufunika chidwi chochulukirapo, popeza kuchuluka kwake kungatsike ndi kuchuluka kwa njira zoletsa mu cortex ya ubongo.

Kuunika kwa akatswiri ndi odwala

Ndemanga za madotolo za Gabapentin ndizabwino kwambiri, mankhwala omwe amagwiritsidwa ntchito ndiwofanana ndi mulingo wogwira ntchito mankhwalawa.

Ndemanga za odwala omwe adatenga Gabapentin kuti athetse ululu wa neuropathic nthawi zambiri zimakhala zoyipa, odwala amawona zoyipa kuchokera pakumwa mapiritsi a Gabapentin kuchokera m'matumbo am'mimba komanso zovuta zamitsempha, komanso kudziwonetsa mwachangu. Maphunzirowa atatha, chithandizo cha kugona, nkhawa komanso kugona nthawi zonse zimadziwika.

Igor, wazaka 31: "Chidwi chinayambira, sizovuta kudya ngakhale popanda kumwa kotsatira. Ndili ndi vuto lomwe sindingakane kumwa mapiritsi, sindinaphonye - ali ngati mtundu wa mankhwala.

Mlingo wanga ndiwokhazikika pa 400 mg katatu patsiku pachaka chachinayi. Tsopano ndazindikira kuti ndimakhala wokhumudwa komanso wodzipha m'mutu mwanga. Malingaliro ndiopenga, kumverera kuti ndataika kale malingaliro ndipo winawake akundiganizira. Tsopano ndi nthawi yoti dokotala amupatse chithandizo chamankhwala. ”

Gabapentin ndi mankhwala othandiza kuthetseratu zinthu zopweteka, kuletsa kupweteka kwa mitsempha komanso kupewa kugwidwa. Kutengera ndi malamulo oyendetsera komanso kumwa mankhwalawa, ndikotheka kukwaniritsa kuchotsedwa kwa matenda amitsempha popanda zovuta komanso zosokoneza mbali ya thupi.