Tsifran OD (Сifran OD)

Mankhwala Ciprofloxacin imagwira ntchito mu vitro osiyanasiyana a gram-negative ndi gram-virus. Machitidwe a bactericidal a ciprofloxacin ndi chifukwa choletsa ma enzyme topoisomerase II (DNA gyrase) ndi topoisomerase IV, zomwe ndizofunikira kuti zithembedwe, kusindikizidwa, kukonza, komanso kubwezeretsanso DNA ya bakiteriya. Kapangidwe kake ka fluoroquinolones, kuphatikiza ciprofloxacin, kosiyana ndi kamangidwe ka penicillins, cephalosporins, aminoglycosides, macrolides ndi tetracyclines. Chifukwa chake, tizilombo tating'onoting'ono tomwe timagwiritsa ntchito mankhwalawa titha kumvetsetsa chiprofloxacin ndi ma quinolones ena. Palibe kudziwika kosagwirizana pakati pa ciprofloxacin ndi magulu ena a antibacterial mankhwala. Kukaniza mu vitro ciprofloxacin imayamba pang'onopang'ono. Ciprofloxacin imagwira ntchito molimbana ndi mitundu ingapo ya zinthu zotsatirazi monga mu vitromatenda opatsirana,
tizilombo tating'onoting'ono ta gramu: Enterococcus faecalis (mitundu yambiri imakhala yovutikira), Staphylococcus aureus (MSSA), Staphylococcus epermidis (MSSA), Staphylococcus saprophyticus, Streptococcus pneumoniae (PSSP), Streptococcus pyogenes,
maerobic gram osavomerezeka: Campylobacter jejuni, Citrobacter diversus, Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Straissergioerioerius geriomerio derio drio derio derio derio. , Serratia marcescens, Shigella sonnei, Shigella boydii, Shigella dysenteriae, Shigella flexneri.
Ciprofloxacin imagwiranso ntchito mu vitro ndikugwiritsa ntchito cholembera chokhala ndi Bacillus anthracis. Ciprofloxacin ali mu vitro osachepera zoletsa zina (MIC) ≤1 μg / ml poyerekeza ndi mitundu yambiri (90%) yama tizilombo totsatirawa:
tizilombo tating'onoting'ono ta gramu: Staphylococcus haemolyticus, Staphylococcus hominis, Streptococcus pneumoniae (PRSP),
maerobic gram osavomerezeka: Acinetobacter iwoffi, Pasteurella multocida, Aeromonas hydrophila, Salmonella enteritidis, Edwardsiella tarda, Vibrio Cholerae, Enterobacter aerogene, Vibrio parahaemolyticus, Klebsiella oxytoca, Vibrio vulnificus, Legionellainophocolila.
Mitundu yambiri Burkholderia cepacia ndi zina zovuta Stenotrophomonas maltophilia kugonjetsedwa ndi ciprofloxacin, monga ma bacteria ambiri a anaerobic, kuphatikiza Bacteroides fragilis ndi Clostridium Hardile.
Pharmacokinetics Mapiritsi okhazikika a peprofloxacin amapangidwa kuti azitha kutulutsa mankhwala pang'onopang'ono kuposa mapiritsi wamba. Mapiritsi otsekemera a ciprofloxacin okhazikika ndi mapiritsi akumasulidwa a ciprofloxacin samasinthasintha. Mbiri ya pharmacokinetic ya ciprofloxacin mapiritsi olimbikitsidwa a 500 ndi 1000 mg pamene amamwa kamodzi patsiku amafanana ndi a mapiritsi a 250 ndi 500 mg ndikamasulidwa msanga akamatengedwa kawiri patsiku malinga ndi AUC kwa maola 24.
Kuchulukitsa kwa iv intravenous ciprofloxacin kuli pafupi 2.1-2.7 l / kg kulemera kwa thupi. Zotsatira za kafukufuku wochitika ndi pakamwa komanso / kugwiritsa ntchito ciprofloxacin, zikuwonetsa kuti, kutengera njira yogwiritsira ntchito, mankhwalawa amalowa m'misempha yosiyanasiyana. Kumangidwa kwa ciprofloxacin ndi mapuloteni a seramu ndi 2040%. Ma metabolites 4 omwe adadziwika mu mkodzo adalembedwa. Ma metabolites awa sananene zochita za antimicrobial kuposa chiprofloxacin yosasinthika. Kupukusira kwa metabolites kumeneku kumachitika pafupifupi mkati mwa maola 24 mutatha kugwiritsa ntchito mankhwala. Otetezedwa-kumasulidwa kinetics a ciprofloxacin ali ofanana ndi omwe amasulidwa mapiritsi a ciprofloxacin posachedwa. Pafupifupi 35% ya mlingo wakamwa umachotsedwa mu mkodzo. Kuchiritsa kwa urin kumachitika pafupifupi pakatha maola 24 mutatha kugwiritsa ntchito mankhwalawa. Pafupifupi 20-35% ya khomo lokhala ndi mankhwala a ciprofloxacin amasulidwa nthawi yomweyo. Odwala ndi aimpso kuchepa, hafu ya moyo wa ciprofloxacin imatenga nthawi yayitali.

Mlingo

makanema ojambula okhala ndi mafilimu okhazikika.

piritsi lililonse lokhazikika lotulutsa filimu yokhala ndi: Cyfran OD 500 mg
Zogwira ntchito: ciprofloxacin - 500 mg. Tsifran OD 1000 mg
Zogwira ntchito: ciprofloxacin - 1000 mg.
Omwe amachokera: sodium alginate (Keltone LVCR), hypromellose, sodium bicarbonate, crospovidone (CLM), magnesium stearate, colloidal silicon dioxide (200), talc.

Filamu wachimvekere:
Opadry yoyera 31B58910, talcum ufa, hypromellose, madzi oyeretsedwa, inki yakuda yolemba (Opakod -S-1-17823 wakuda).
kapangidwe ka opadra yoyera 31B58910: hypromellose, lactose, titanium dioxide, macrogol 400, evaporates popanga,
Kuphatikizikako ndikuphatikizapo: shellac 45% (20% yotsimikizika) mu ethanol, isopropanol, n-butanol, propylene glycol, ammonia wamadzi 28%, utoto wakuda wachitsulo.

Kutulutsa Fomu

Mapiritsi ogwira ntchito kwa nthawi yayitali, ophatikizidwa ndi 500 mg, 1000 mg. Mapiritsi 5 okhala ndi paketi yokhala ndi zozungulira za aluminiyumu mbali imodzi ndi zojambulazo za aluminiyumu zokutira ndi filimu ya polyamide ndi filimu ya PVC mbali inayo, matuza 1 kapena 2 okhala pabokosi lamakhadi okhala ndi malangizo ogwiritsira ntchito.

Mapiritsi "Tsifran OD 500 mg"
Mapiritsi okhala ndi mawonekedwe ozungulira, kuyambira oyera mpaka pafupi oyera, ovala-kanema, pa umodzi wa
mbali ya piritsi inki yosindikiza "Cifran OD 500MG".

Mtundu wa piritsi pamapeto:
kupanikizika misa kuyambira yoyera mpaka pafupi yoyera.

Mapiritsi "Tsifran OD 1000 mg"
Mapiritsi okhala ndi mawonekedwe ozungulira, kuyambira oyera mpaka pafupi oyera, okhala ndi filimu, "Cifran OD 1000MG" amasindikizidwa mbali imodzi ya piritsi ndi inki ya chakudya.
Mtundu wa piritsi pamapeto: kuponderezedwa misa kuyambira yoyera mpaka pafupifupi yoyera.

Dzinalo Lopanda Padziko Lonse

Dongosolo la malonda la mankhwalawa ndi Cifran®. Dzinalo losavomerezeka padziko lonse lapansi ndi Ciprofloxacin (Ciprofloxacin). Mu Chilatini - Ciprofloxacinum.

Ciphran imagwira ntchito polimbana ndi bacteria ndi tizilombo ta tizilombo tating'onoting'ono tomwe timagwira.

J01MA02 Systemic antibacterial mankhwala.

Zotsatira za pharmacological

Ciphran amagwira ntchito yolimbana ndi ma bacteriophages ambiri ndi tizilombo ta tizilombo tating'onoting'ono tomwe timagwirizana ndi aminoglycosides. Chifukwa chake, akatswiri azaumoyo amalimbikitsa mankhwalawa kuti athane ndi matenda osakanikirana omwe amayambitsidwa ndi anaerobic, mabakiteriya aerobic ndi matenda am'mimba. Mphamvu ya bactericidal ya ciprofloxacin imatheka chifukwa chokhoza kuletsa kaphatikizidwe ka michere yofunika pa moyo wa tizilombo.

Ogwira ntchito zachipatala amalimbikitsa Cifran kuti athane ndi matenda osakanikirana.

Pharmacokinetics

Amatengeka mwachangu kuchokera kumtunda kwamatumbo ang'ono. The pazipita kuchuluka kwa mankhwala mthupi kumachitika pambuyo 1-1,5 maola pambuyo makonzedwe. Poterepa, kugwiritsa ntchito chakudya sikumakhudza kuchuluka kwa mayamwidwe.

Biotransformed mu chiwindi. Imayamba kuchotsedwa m'thupi pambuyo pa maola 3-5, makamaka ndi mkodzo komanso pang'ono m'matumbo. Mwa anthu omwe ali ndi matenda a impso, nthawi yeniyeni ya mankhwalawa imatenga nthawi yayitali.

Zomwe zimathandiza

Amawonetsera matenda osavuta komanso ovuta omwe amayamba chifukwa cha matenda:

• dongosolo la broncho-pulmonary,
• Ziwalo za ENT
• diso
• m'kamwa
• dongosolo la impso ndi urogenital,
• m'mimba
• musculoskeletal system.

Kwa ana, mankhwalawa amapatsidwa mankhwala ochizira zowonongeka zomwe zimayenderana ndi pulmonary cystic fibrosis.

Contraindication

Digito sinafotokozedwe ngati wodwala ali:

• chidwi ndi mankhwala ochokera ku gulu la quinolone,
• pseudomembranous colitis,
• mtundu uliwonse wa khunyu.

Digital siyikulimbikitsidwa kuti igwiritsidwe ntchito pa nthawi yoyembekezera komanso nthawi yotsatsa.

Kuphatikiza apo, malinga ndi malangizo ogwiritsira ntchito, chida ichi sichiri chovomerezeka kuti chitha kugwiritsidwa ntchito panthawi yomwe muli ndi pakati komanso nthawi ya mkaka wa msambo.

Ana ndi achinyamata amafunsidwa kuti azingolimbana ndi matenda obwera chifukwa cha cystic fibrosis kapena kuopseza kachilomboka.

Ciphran sagwiritsidwa ntchito limodzi ndi tizanidine.

Ndi chisamaliro

Mosamala, odwala azaka amadziwika, komanso:

• ndi ubongo arteriosulinosis ndi kuchuluka kwachuma kwamkati,
• ndi matenda amtima
• ndi zolephera zamagetsi,
• ndi aimpso ndi / kapena hepatic pathologies,
• ndi matenda amisala komanso khunyu.

Digital 500 imatengedwa musanadye, popanda kutafuna ndikumwa ndi madzi.

Imakhala ndi malire ngati munthu wapezeka ndi matenda am'mitsempha yamagalimoto oyipitsidwa chifukwa chotenga fluoroquinolones.

Momwe mungatenge Tsifran 500

Muzidya musanadye, osafuna kutafuna kapena kumwa madzi.

Akuluakulu ochizira matenda omwe amachitika:

• m'mitundu yopepuka ndi yapakatikati - 0,25-0,5 g kawiri pa tsiku,
• woopsa kapena wovuta mawonekedwe - 0,75 g kawiri pa tsiku.

Kutalika kwa mankhwala kutsimikizika ndi mawonekedwe ndi zovuta za njira ya matenda opatsirana. Ma regimens a mankhwala amathandizidwa ndi dokotala.

Mulingo umodzi wampingo umodzi wa mankhwalawo ndi 0,75 g, tsiku lililonse - osapitirira 1.5 g.

Mu matenda a chiwindi kapena impso, mulingo woyenera wa tsiku lililonse sayenera kupitirira 0,8 g (0,2-0.4 g maola 12 aliwonse).

Ngati wodwala ali ndi matenda ashuga, ma regimens othandizira odwala amapatsidwa ndi dokotala payekhapayekha.

Ndi matenda ashuga

Ciprofloxacin amakhulupirira kuti imathandizira mankhwala a hypoglycemic. Chifukwa chake, mankhwalawa akaphatikizidwa, mwachitsanzo, ndi glibenclamide kapena glimepiride, matenda a hypoglycemic amatha.

Ngati wodwala ali ndi matenda ashuga, ma regimens othandizira odwala amapatsidwa ndi dokotala payekhapayekha.

Kuchokera pamtima

Kuchuluka kwa palpitations, arrhythmia, tachycardia, kusintha magazi.

Tsifran ikhoza kuyambitsa zovuta mu mawonekedwe a mtima palpitations, arrhythmias, tachycardia, kusintha kwa magazi.

Pakati mantha dongosolo

Odwala ena amawonetsa zizindikiro za asthenia, kusokonezeka kwa kugona, kuda nkhawa, kusamva, kusokonezeka kwa zipatso, etc.

Odwala ena amakhala ndi zovuta kugona.

Angioneurotic edema, zotupa pakhungu, kuyabwa ndi mawonekedwe anaphylactic (osowa).

Malangizo apadera

Odwala omwe mbiri yawo ya zamankhwala imakhala ndi chidziwitso cha khunyu, zopweteka, zotupa za m'mimba kapena zotupa zama ubongo zimakhala pachiwopsezo chokana kuyankha kokwanira kuchokera ku dongosolo lamkati la mantha. Nthawi zina, mkhalidwe wama psychosis umachitika, limodzi ndi kuyesayesa kudzipha. Chifukwa chake, mankhwalawa amangoikidwa pazisonyezo zofunika.

Mukamagwiritsa ntchito mankhwalawa, kuyatsidwa ndi dzuwa kuyenera kupewedwa, chifukwa zimathandizira kuwonetsa kwa photosensitivity.

Gwiritsani ntchito mu ukalamba

Kwa odwala okalamba omwe ali ndi vuto losakhazikika, omwe kale ankathandizidwa ndi glucocorticosteroids, pamakhala chiopsezo chotupa cha Achilles tendon. Chifukwa chake, ngati zizindikiro za tendonitis zikuwoneka, makonzedwe a cyfran amayenera kuletsedwa.

Kwa odwala okalamba omwe ali ndi vuto losakhazikika, pali chiopsezo chotupa cha tendon ya Achilles.

Bongo

Zizindikiro: mawonekedwe a chizungulire, kupweteka mutu, kumva kufooka, nseru, ndi kusanza. Pankhani ya mankhwala osokoneza bongo, ndikofunikira kuchita njira zochotsetsereka:

• chifuwa cham'mimba,
• kuyimitsidwa kwa zakudya
• kudya kashiamu ndi mankhwala a magnesium,
• kugwiritsa ntchito voliyumu yayikulu yamadzi.

Kuphatikiza apo, amafunika kuwunika momwe mkodzo amagwirira ntchito, popeza osagwiritsa ntchito mankhwalawo, zotsatira zoyipa za impso zimadziwika.

Kuchita ndi mankhwala ena

Ndi munthawi yomweyo kugwiritsa ntchito mankhwala a mtima, antidepressants ndi antipsychotic, adayikidwa mosamala.

Kuphatikiza ndi Theophylline, imathandizira zotsatira zake ndikuthandizira kuchepa kwa thupi.

Pogwiritsa ntchito munthawi yomweyo ndi phenytoin, kusintha kwa kupezeka kwake m'magazi kumawonedwa. Kupatula kupezeka kwa zinthu zopweteketsa, kuwongolera chithandizo cha phenytoin ndikofunikira panthawi yonse ya mankhwala olowa.

Ma NSAIDs (kupatula acetylsalicylic acid) osakanikirana ndi mitundu yayikulu ya quinolones angayambitse kugwidwa.

Cyclosporin wophatikizika ndi Cyfran amathandizira kuwonjezera creatinine m'thupi.

Probenecid imachedwa kutuluka kwa ciprofloxacin mu mkodzo.

Kuphatikiza ndi methotrexate, imachepetsa mayendedwe ake a impso ndikuwonjezera ndende.

Kugwiritsa ntchito kovuta kwa Cyfran ndi mavitamini a vitamini K kumathandizira kuti katundu wawo azikhala wolimba.

Kuphatikiza ndi ropinirole kapena lidocaine, chiopsezo chokhala ndi zotsatira zoyipa chimawonjezeka.

Kuphatikiza ndi warfarin, kumawonjezera mwayi wokhetsa magazi.

Analogue ya kapangidwe ka Cifran pazogwira ntchito ndi Ciprolet.

Zofanizira mwazinthu zomwe zimagwira ntchito ndi:

• Alcipro
• Tsiprolet,
• Ciprolone
• Tsiprobay,
• Cypropane
• Tsiprosan
• Tsiprosin
• Cyprosol,
• Chiprofloxabol,
• Ciprofloxacin,
• Cigral
• Tsiflokinal,
• Tsifran OD,
• Tsifran ST,
• Ecocifol ndi ena.

Kutalika kwa mankhwala kutsimikizika ndi mawonekedwe ndi zovuta za njira ya matenda opatsirana.

Umboni wa madotolo ndi odwala za Tsifran 500

Berezkin A.V., wothandizira, Mezhdurechensk

Mankhwala othandizira otsogola omwe amagwiritsidwa ntchito popanga opaleshoni, mano, matenda a mano, urology ndi zina zapadera. Ine ndekha ndikulemba mankhwalawa kawirikawiri, pokhapokha ngati pali umboni kapena ngati prophylaxis pambuyo pa opaleshoni ya purapy ndi kuvulala. Ndimaona kuti ndiothandiza komanso yabwino kugwiritsa ntchito.

Kornienko L.F., dokotala wazamankhwala, Irkutsk

Mankhwala ndi oyenera kuti athandizire kunja matenda a kutupa kwa matenda ammimba. Zochita zingapo zowonekera zimatsimikiza kuyipa kwa mankhwalawa.

Alla, wazaka 25, Ufa

Amakhala ndi zilonda zapakhosi, ndipo adotolo adapereka mapiritsi 500 a Cyfran kamodzi patsiku. Kuchipatala chapafupi kwambiri mulingo woyenera wa mankhwalawa sichinali. Ndinagula Mlingo wa 250 mg ndipo ndinamwa mapiritsi awiri nthawi imodzi. Angina adadutsa masiku atatu, koma sanasokoneze maphunzirowo. Adatenga masiku 10. Zotsatira zoyipa: kuyambika kwadzidzidzi kwa tachycardia ndi dysbiosis ndi njira yosasangalatsa. Tsopano ndikumvera za mankhwalawa ndipo sindingathe kuzimva ngakhale pakulimbikitsidwa ndi dokotala.

Zisonyezero zamankhwala Tsifran OD

Matenda osakhazikika komanso ovuta omwe amayamba chifukwa cha tizilombo toyambitsa matenda omwe amapezeka ndi ciprofloxacin:

• matenda opatsirana thirakiti: chibayo choyambitsidwa ndi Klebsiella spp., Enterobacter spp., Proteus spp., Escherichia coli, Pseudomonas aeruginosa, Haemophilus spp., Moraxella catarrhalis, Legionella ndi staphylococci,
• matenda a khutu lapakati ndi paranasal sinuses,
• matenda am'mimbamo, matenda a m'mimba otaya, ndulu ya ndulu ndi chindoko, komanso peritonitis,
• matenda a impso ndi kwamkodzo
• matenda a m'chiuno (chinzonono, adnexitis, prostatitis),
• matenda a pakhungu ndi minofu yofewa,
• matenda a mafupa ndi mafupa.

Kugwiritsa ntchito mankhwala Tsifran OD

Mankhwala amatengedwa mutatha kudya. Piritsi limeza lonse. Osadula, kuphwanya, kapena kutafuna piritsi. Mlingo wa wodwala aliyense amasankhidwa poganizira kulemera kwa thupi, mtundu wa pathogen, chidwi cha pathogen, momwe chitetezo chamthupi cha wodwalayo chimagwirira ntchito, komanso impso ndi chiwindi. Kutalika kwa chithandizo kumatengera kuopsa kwa matendawa ndipo nthawi zambiri amakwana masiku 7 mpaka 14.Komabe, chifukwa cha matenda oopsa kapena ovuta, chithandizo chambiri chingafunike.

Mlingo wofanana wa iv ciprofloxacin

500 mg (piritsi 1) Cyfran OD 1 nthawi patsiku

200 mg maola 12 aliwonse

1000 mg (piritsi 1) Cyfran OD 1 nthawi patsiku

400 mg maola 12 aliwonse

Odwala ndi mkhutu aimpso ntchito, makamaka ndi aimpso kulephera, kusintha kwa mankhwala kumafunika.
Gome ili pansipa lili ndi malingaliro othandizira odwala omwe ali ndi vuto laimpso.

Chilolezo cha Creatinine, ml / mphindi

Mlingo Wothandizidwa

Mapiritsi Tsifran OD 500-1000 mg 1 nthawi patsiku

Mapiritsi a Cifran OD sanalimbikitsidwe; mapiritsi apadera amprofloxacin angagwiritsidwe ntchito mwanjira iyi: 250-500 mg wa ciprofloxacin maola 18 aliwonse

Odwala pa hemo- kapena peritoneal dialysis

Mapiritsi a Cifran OD osavomerezeka, mapiritsi ochiritsira amatha kugwiritsidwa ntchito mwanjira iyi: 250-500 mg ya ciprofloxacin maola 24 aliwonse (pambuyo pa dialysis)

Odwala ndi creatinine chilolezo ≤30 ml / mphindi kwa zovuta kwamikodzo thirakiti ndi pachimake zovuta pyelonephritis, mlingo ndi 500 mg wa Cyfran OD kamodzi patsiku.

Ngati kuchuluka kwa creatinine m'magazi seramu ndikudziwika, njira zotsatirazi zingagwiritsidwe ntchito kuwunika chilolezo cha creatinine:

kwa amuna:


creatinine chilolezo (ml / min) =

Kulemera kwa thupi (kg) × (140 - zaka)

72 (plasma creatinine (mg / dl)

Palibe chifukwa chosinthira mlingo wa ciprofloxacin kwa odwala omwe ali ndi njira yokhazikika yodwala matenda a chiwindi. Komabe, pharmacokinetics ya ciprofloxacin mwa odwala omwe ali ndi vuto la chiwindi pachaka sanayambe afufuzidwa kwathunthu.

Zotsatira zoyipa za mankhwala Tsifran OD

Maulendo ≥1, ≤10%
Ziwalo zam'mimba: nseru, kutsegula m'mimba.
Khungu: zotupa pakhungu.
Frequency ≥0.1, ≤≤1%
Thupi lonse: kupweteka kwam'mimba, candidiasis, asthenia.
Ziwalo zam'mimba: kuchuluka kwa hepatic transaminases: AlAT, AsAT, zamchere phosphatase, kusanza, dyspepsia, anorexia, flatulence, bilirubinemia.
Dongosolo la Hematopoietic: eosinophilia, leukopenia.
Njira zamankhwala: kuchuluka kwa creatinine, urea nayitrogeni.
Makina a minofu ndi mafupa: arthralgia.
CNS: chizungulire, kupweteka mutu, kusokonezeka kwa tulo, kukwiya, chisokonezo.
Khungu: kuyabwa, zotupa pakhungu la maculopapular chikhalidwe, urticaria.
Zosangalatsa: kulakwira.
Frequency ≥0.01, ≤≤0.1%
Thupi lonse: kupweteka, kupweteka m'miyendo, kupweteka kumbuyo, pachifuwa.
Matenda a mtima: tachycardia, migraine, syncope, vasodilation, hypotension.
Ziwalo zam'mimba: candidiasis (mkamwa), jaundice, cholestatic jaundice, pseudomembranous colitis.
Mwazi ndi magazi a m'mimba: kuchepa magazi, leukopenia (granulocytopenia), leukocytosis, kusintha kwa mulingo wa prothrombin, thrombocytopenia, thrombocythemia (thrombocytosis).
Hypersensitivity: thupi lawo siligwirizana, mankhwala malungo, anaphylactic zimachitika.
Matenda a Metabolic: edema (zotumphukira, zotupa, nkhope), hyperglycemia.
Makina a minofu ndi mafupa: myalgia, kutupa kwa mafupa.
CNS: migraine, kuyerekezera zinthu m'magazi, thukuta, paresthesia (zotumphukira paralgesia), nkhawa (mantha, nkhawa), kusokonezeka kwa tulo (zolota), kupsinjika, Hypersthesia, kukhumudwa, kugwedezeka.
Machitidwe opatsirana: dyspnea, laryngeal edema.
Khungu: photosensitivity reaction.
Zosangalatsa: tinnitus, kugontha kwakanthawi (makamaka pamtunda wambiri), kuwonongeka kwa mawonekedwe (mawonekedwe oyipa), diplopia, chromatopsia, kuchepa kwa kukoma (kuwonongeka).
Dongosolo la genitourinary: ARF, kuwonongeka kwa impso, vagidi candidiasis, hematuria, crystalluria, interstitial nephritis.
Maulendo ≤0.01%
Matenda a mtima: vasculitis.
Ziwalo zam'mimba: candidiasis, chiwindi necrosis (kawirikawiri - kupita patsogolo ndi chitukuko cha chiwopsezo cha chiwindi), pseudomembranous colitis ndi zotheka kupha, kapamba, hepatitis.
Mwazi ndi magazi a m'mimba: hemolytic anemia, petechiae, agranulocytosis, pancytopenia (ndikuwopseza moyo), zoletsa za mafuta m'mafupa (zowopseza moyo).
Hypersensitivity: kugwedezeka (anaphylactic, kuwopseza moyo), zotupa pakhungu, kuyankha kofanana ndi matenda a seramu.
Matenda a Metabolic: kuchuluka kwa amylase ndi / kapena magazi lipase.
Makina a minofu ndi mafupa: myasthenia gravis, tendonitis (makamaka Achilles tendon tendonitis), pang'ono kapena kupasuka kwa tendon (makamaka Achilles tendon).
CNS: zopweteka kwambiri minofu yayikulu, kukhazikika kwa gait, psychosis, intracranial matenda oopsa, ataxia, Hypersthesia, tic.
Khungu: petechiae, erythema multiforme, erythema nodosum, matenda a Stevens-Johnson, epidermal necrolysis (matenda a Lyell), chotupa cha khungu chopitilira.
Zosangalatsa: parosmia, kuchepa kwa fungo (nthawi zambiri chimasinthidwa mankhwala ataletsedwa).

Zochita ndi Mankhwala Cifran OD

Kugwiritsa ntchito munthawi yomweyo tizanidine ndi ciprofloxacin ndi zotsutsana. Monga ndi quinolones ena, kuphatikizidwa kwa chiprofloxacin ndi theophylline kungayambitse kuchuluka kwa theophylline mu seramu yamagazi ndi kutalikitsa kwa theka la moyo wawo. Izi zitha kukulitsa chiwopsezo cha zotsutsana ndi theophylline. Ngati kugwiritsa ntchito mankhwalawa kwa mankhwalawa sikungapeweke, mulingo wa serum theophylline uyenera kuyang'aniridwa ndikuti mankhwalawa amathandizidwa molondola.
Ma quinolones ena, kuphatikiza ciprofloxacin, amakhudza kagayidwe kachakudya. Izi zingayambitse kuchepa kwa chilolezo cha caffeine komanso kutalika kwa moyo wake kuchokera ku seramu.
Kugwiritsa ntchito munthawi yomweyo mankhwala aliwonse a kalasi ya quinolone, kuphatikizapo ciprofloxacin, omwe ali ndi mankhwala ochulukirapo a cationic, monga maacacid okhala ndi magnesium kapena aluminium hydroxide, sucralfate, mapiritsi a chetanosine, kapena zinthu zomwe zimakhala ndi calcium, chitsulo kapena zinki, zitha kuchepetsa mayamwidwe ake, chifukwa kubweretsa kuchuluka kwa seramu ndi mkodzo kumakhala kotsika kwambiri kuposa koyenera.
Otsutsa a histamine H2 receptors, mwachiwonekere, samakhudza kwambiri bioavailability wa ciprofloxacin. Kuperewera kwa mapiritsi a Cyfran OD amatsika pang'ono (20%) ngati atagwiritsidwa ntchito limodzi ndi omeprazole.
Kusintha kwa serum phenytoin mulingo (kuchuluka kapena kuchepa) kunawonedwa mwa odwala omwe amatenga ciprofloxacin nthawi yomweyo.
Kugwiritsa ntchito ciprofloxacin kuphatikiza ndi sulfonylurea sikunayambitse kwambiri hypoglycemia.
Kulandilidwa kwa quinolones ena, kuphatikiza ciprofloxacin, kunalumikizidwa ndi kuwonjezeka kwakanthawi kochepa kwa serum creatinine mwa odwala omwe amatenga cyclosporine nthawi yomweyo.
Pakhala pali ndemanga kuti quinolones, kuphatikizapo ciprofloxacin, imathandizira kuchitira kanthu kwa anticoagulant warfarin kapena zotumphukira zake. Ngati ndi kotheka, munthawi yomweyo kugwiritsa ntchito mankhwalawa kuyenera kuwunika nthawi ya prothrombin nthawi ndi zizindikiro zina zamagazi. Probenecid imakhudza katulutsidwe ka ciprofloxacin ndi aimpso tubules, chifukwa chomwe kuchuluka kwa ciprofloxacin mu seramu yamagazi kumachulukana. Izi ziyenera kuganiziridwa ngati wodwala amamwa onse awiri nthawi yomweyo.
Kuyendetsa kwa Methotrexate ndi aimpso tubules kumatha kuponderezedwa ndi kugwiritsa ntchito munthawi yomweyo ciprofloxacin, zomwe zingayambitse kuchuluka kwa plasma methotrexate. Izi zitha kukulitsa chiopsezo cha poizoni wambiri chifukwa cha methotrexate. Odwala omwe amalandila mankhwala a methotrexate amafunika kuwunika mozama ngati mankhwala a chiprofloxacin amapatsidwa nthawi yomweyo.
Metoclopramide imathandizira kwambiri kuyamwa kwa kaprofloxacin wamkamwa, potero kumawonjezera nthawi kuti ifikire nthawi yayitali ndende yamagazi. Komabe, sizinasinthe pa bioavailability ya ciprofloxacin.

Magulu apadera a odwala

Mu kuwonongeka kwa impso: Odwala omwe ali ndi vuto laimpso pang'ono, theka la moyo wa ciprofloxacin lingachuluke. Pankhaniyi, kukonza njira yofunikira ndikofunikira.

Ngati chiwindi ntchito: Muzoyambirira maphunziro a odwala okhazikika njira ya chiwindi, palibe kusintha kwakukulu mu pharmacokinetics of ciprofloxacin adadziwika. Komabe, kafukufuku pa kinetics wa ciprofloxacin mwa odwala omwe ali ndi vuto la chiwindi champhamvu sanachitike.

Gwiritsani ntchito pa nthawi ya pakati komanso poyamwitsa

Cifran OD siyikulimbikitsidwa kuti mugwiritse ntchito panthawi yomwe muli ndi pakati.
Ciprofloxacin imafukusidwa mkaka wa m'mawere, motero mukamayamwa, ngati mukufunika kugwiritsa ntchito Cifran OD, potengera kufunika kwa kugwiritsidwa ntchito kwake kwa amayi, muyenera kusankha kuti musiyeni kumwa mankhwalawa kapena kuyamwitsa.

Mlingo ndi makonzedwe

Mkati.
Osaphwanya, kutafuna, kapena kuwononga mapiritsi. Mapiritsi amayenera kumwedwa pakamwa atatha kudya kwathunthu, ndi madzi ambiri.
Kugwiritsa ntchito kwa Tsifran OD kuyenera kupitiliza kwa masiku ena awiri atatha zizindikilo zonse za matendawa.
Mlingo woyenera wa akulu:

Malangizo a regimen mu refund kulephera:
Ngati vuto la impso, vuto lotsatira la makulidwe a akulu limalimbikitsa:

Ngati plasma creatinine ndende ikudziwika, njira zotsatirazi ndizoyenera
matanthauzidwe apadera a creatinine:
Amuna:

Kutalika kwa Creatinine (ml / min.) = Kulemera kwa thupi (kg) x (140 - zaka) / 72 x serum creatinine ndende (mg%)
Akazi:
Creatinine chilolezo (ml / min.) = 0,85 x chizindikiro chowerengedwa kwa amuna.

Zotsatira zoyipa

Kuchokera m'mimba: nseru, kusanza, kutsegula m'mimba, kupweteka kwam'mimba, kugona, kugona m'mimba, cholestatic jaundice (makamaka odwala omwe ali ndi matenda am'mbuyomu), chiwindi, hepatonecrosis.

Kuchokera ku dongosolo lamanjenje: chizungulire, Photophobia, kusowa tulo, paresthesia, kusakhazikika, kupweteka mutu, kuchuluka kutopa, nkhawa, kunjenjemera, "maloto" amtendere ", zotumphukira paralgesia (anomaly mu malingaliro a ululu), kuchuluka kwazovuta, kusokonezeka, kuyerekezera zinthu, komanso mawonekedwe ena. psychotic zimachitika (nthawi zina kupita kumalo kumene wodwala amadzivulaza), migraine, kukomoka, matenda amitsempha yamagazi.

Kuchokera ku ziwalo zomverera: Kusokoneza kukoma ndi kununkhiza, kuwonongeka kwa mawonekedwe (diplopia, discoloration), tinnitus, kusamva kwa makutu.

Kuchokera pamtima: tachycardia, mtima arrhythmias, kuchepa kwa magazi, kuthira magazi pakhungu la nkhope.

Kuchokera ku hematopoietic system: eozoftft, leukopenia, granulocytopenia, kuchepa magazi, thrombocytopenia, leukocytosis, thrombocytosis, hemolytic anemia.

Zizindikiro zasayansi: hypoprothrombinemia, kuchuluka kwa "chiwindi" transaminases, hypercreatininemia, hyperbilirubinemia, hyperglycemia, kuchuluka kwa zamchere phosphatase ndi lactate dehydrogenase.

Kuchokera pamikodzo: hematuria, crystalluria (makamaka ndi zamchere zamkodzo ndi otsika diuresis), pachimake nephritis (ndi chitukuko cha kupweteka kwaimpso), glomerulonephritis, dysuria, polyuria, kwamikodzo posungira, albuminuria, urethral magazi, kuchepa kwa nayitrootherapy yogwira ntchito.

Zotsatira zoyipa: kuyabwa pakhungu, ming'oma, mapangidwe amadzimadzi othamanga ndi kutulutsa magazi, komanso mawonekedwe amiyendo yaying'ono yopanga, kutentha kwa mankhwalawa, zotupa pakhungu (petechiae), kutupa kwa nkhope kapena larynx, dyspnea, vasculitis, erythema nodosum, erythema multiforme exudative (erythema multiforme exudative (erythema multiforme exudative) Stevens-Johnson syndrome), poermal necrolysis yoopsa (matenda a Lyell).

Kuchokera ku minculoskeletal system: arthralgia, nyamakazi, tendovaginitis, kupindika kwa tendon, myalgia.

Zina: thukuta kwambiri, photosensitivity, kufooka wamba, kupatsirana kwakukulu (candidiasis, pseudomembranous colitis).