Zomwe zili bwino lypimar kapena krestor

Owerenga athu adagwiritsa ntchito bwino Aterol kutsitsa cholesterol. Kuwona kutchuka kwa malonda, tidaganiza zoperekera chidwi chanu.

Ma Statist amachepetsa kupanga cholesterol ndi chiwindi chifukwa kuchepa kwa zomwe zili m'magazi. Zinthu zamphamvu izi zimalepheretsa enzymatic ntchito ya HMG - CoA reductase, yomwe imapanga cholesterol. Amatha kuchepetsa chiwopsezo cha kugunda kwa mtima ndikuchotsa njira zotupa m'matumbo.

Zizindikiro ndi contraindication
Zotsatira zoyipa
Rosuvastatin
Atorvastatin
Simvastatin
Fluvastatin
Lovastatin
Zokhudza kugwiritsa ntchito mankhwala osokoneza bongo
Kodi ndikofunikira kuchotsa LDL pamlingo wa 7 mmol / l?
M'malo mwa Statin

Zizindikiro ndi contraindication

Atalandira zotsatira za mayeso, adotolo atha kutumiza mankhwala omwe munthu ayenera kumwa kwa nthawi yayitali akuyang'aniridwa ndi achipatala.

Kutenga ma statins kumakhudza:

kutsika kwa biosyntase ya cholesterol ndi chiwindi,
kutsitsa cholesterol yokwanira ndi 45%, LDL yoyipa ndi 60%,
kuchuluka kwa "wabwino" cholesterol wa HDL,
Kuchepetsa kupezeka kwa ischemic zovuta, kugunda kwa mtima, angina pectoris ndi 25%.

Amafuna ndani?

Anthu omwe ali ndi cholesterol apamwamba kuposa 5.8 mmol / l, ndipo pakatha miyezi itatu sichingakonzedwe.
Odwala omwe adachitidwa opaleshoni yowonjezereka pamitsempha yamtima komanso kuti achepetse zovuta, amafunika kutenga njira yankhanza yochizira.
Chifukwa cha prophylactic, odwala omwe ali ndi vuto la mtima kapena stroko ayenera kuvomerezedwa.
Kuvutika ndi matenda amitsempha yamagazi, okhala ndi chiopsezo chowopsa.

Aliyense amene amakonda kwambiri matenda a coronary syndrome, kutenga ma statins ndikofunikira.

Kuti achepetse mavuto, dokotala amayenera kusankha kuti ndi gulu liti la mankhwalawa kuti azichiza wodwalayo, kuwongolera moyenera zamankhwala amtundu uliwonse, ndipo ngati transaminase iwonjezereka katatu, siyani kumwa mankhwalawo.

Kulandila kwa statins ndikotsutsana:

ndi chiopsezo chochepa chotengera matenda amtima,
azimayi asanasiye,
odwala matenda ashuga
ana, komanso anthu azaka zopitilira 75. Kugwiritsa ntchito mankhwalawa ndizoletsedwa chifukwa choti chiwopsezo cha zotsatirapo chidzakulitsidwa chifukwa cholekerera bwino mankhwalawo, ndipo mapindu ake adzakhala ocheperako. Muzochitika zochepa zokha, ana omwe ali ndi vuto la chibadwa komanso LDL yayitali kwambiri m'mwazi ndiomwe amaloledwa kulandira.

Zotsatira zoyipa

Madokotala amati ma statins kuti achepetse cholesterol yochulukitsa moyo, amachepetsa chiopsezo cha kuthamanga kwa mtima ndikuchotsa LDL "yoyipa" m'magazi, zomwe zimayambitsa kuwonjezeka kwa "zabwino".

Pakadali pano, ma statins otetezeka omwe sayambitsa mavuto komanso osavulaza, sanapangidwebe. Simungadzipatse nokha mankhwala, kuda nkhawa ndi cholesterol yayikulu.

Lingaliro lomwe chithandizo chikuyenera kuchitikira ndikuti ndi mankhwala omwe ali oyenera kwa wodwalayo amapangidwa ndi adotolo, potengera zaka, jenda, matenda osachiritsika, zizolowezi zoyipa ndi moyo wa wodwalayo.

Mwa anthu omwe amamwa mankhwalawa kwa nthawi yayitali, zimachitika izi:

kuchokera ku dongosolo lamanjenje: kusokonekera, kusinthasintha kwadzidzidzi, kusokonezeka kwa tulo, chizungulire, kuperewera kwa mitsempha, ma neuropathy kumawonekera, milandu yovutikira kukumbukira kwakanthawi imadziwika.
Kuchokera pamimba: kudzimbidwa, kutsegula m'mimba, kutulutsa magazi, kusefukira, kusanza, kusowa kwa chilakolako cha kudya, kudya magazi, kapamba, mankhwala osokoneza bongo.
kuchokera ku dongosolo la locomotor: minofu wosaloleka komanso kupweteka kwapakati, ululu wammbuyo, kukokana, kupweteka kwa nyamakazi.
Thupi lawo siligwirizana: zotupa, kuyabwa, mphuno, epidermal necrolysis, anaphylactic mantha.
Kuchokera kuzungulira kwa dongosolo: kuchepa kwa magazi kuundana kwa magazi.
kuchokera kumbali ya kagayidwe: kudumpha ndikutsikira m'magazi a magazi.

Zina mwazotsatira zoyipa zingakhale kusabala, kunenepa kwambiri, edema.

Kodi pali mankhwala ati ku Russia?

Ma Statins amasiyana ndi m'badwo wotsiriza wa cholesterol pazomwe zimagwira, koma mu china chilichonse ndiofanana.

Lovastatin

Lovastatin amapangidwa pamaziko a bowa wachilengedwe, amatsitsa cholesterol ndi 25%. Madokotala samapereka mankhwala ngati amenewo, amakonda mankhwala othandiza kwambiri.

Ngati dokotala wakupatsani mankhwalawa, muyenera kumwa ndi mlingo womwe adalimbikitsa. Masiku ano, ulesi, madokotala amatha kupangira mankhwala omwe ali m'thumba la wodwalayo, makamaka popeza chisankho ndichokulirapo.

Zokhudza kugwiritsa ntchito mankhwala osokoneza bongo

Zomwe muyenera kuganizira mukamamwa mankhwala a gululi:

vuto la chiwindi chambiri, ndibwino kumwa rosuvastatins yaying'ono. Mankhwalawa amuteteza ndipo amamuvulaza. Koma mukalandira chithandizo, muyenera kutsatira kadyedwe, kupatula mowa ndi mankhwala othandizira,
Ndi ululu wamisempha, odwala amalangizidwa kuti atenge Pravastatin, yemwe samateteza poizoni yemwe amakhudza minofu.
omwe akudwala matenda a impso sayenera kumwa Fluvastine, Leskol, komanso Atorvastatin, omwe ali ndi poizoni kwambiri.
anthu omwe akuyenera kukwaniritsa kuchepetsa cholesterol amatha kumwa mankhwala osiyanasiyana, monga atorvastatin kapena rosuvastatin.

Ku United States, madokotala posachedwapa apereka ma statins kuti achepetse cholesterol, kudalira kuti amawonjezera moyo wokhala ndi anthu omwe akudwala matenda a mtima. Analimbikitsa kupereka mlingo waukulu wokwanira kwa anzawo aku Russia.

Popeza mankhwalawa sanafufuzidwebe bwino, ndipo mapindu ake anali owonekeratu kuposa zovulaza, chidwi chochepa sichinaperekedwe pazotsatira zoyipa. Koma zidapezeka kuti 20% ya anthu omwe akumwa mankhwala a statin adakumana ndi mavuto.

Malinga ndi ofufuza aku Canada, 57% ya anthu amakhala ndi matenda amkati, ndipo ngati munthu ali ndi matenda ashuga, kuchuluka kwake kumafika pa 82. Izi zikuwonetsa kuti ma statin amachepetsa chiopsezo cha stroketi ndi mtima, koma chifukwa cha zovuta zoyipa, sayenera kutumizidwa. omwe sanadwalidwepo kale ndi nthenda yamtima komanso simunadwalidwenso ndi stroke.

Pali lingaliro lina la asayansi: cholesterol yotsika mtengo ndiyowopsa kwambiri kuposa kukwezedwa, ndipo ma statins amagwira ntchito kuti achepetse.

Ndi cholesterol yotsika, pamakhala chiwopsezo cha neoplasms, kusokonezeka mu ziwindi ndi impso, kusokonezeka kwamanjenje, kuchepa kwa magazi, kufa msanga, ndipo ngakhale milandu yodzipha yadziwika.

Kodi ndikofunikira kuchotsa LDL pamlingo wa 7 mmol / l?

Asayansi ena amati chomwe chimayambitsa matenda a mtima sichikhala ndi cholesterol yayikulu, koma kuchepa kwa magnesium, komwe kumayambitsa matenda ashuga, matenda oopsa, arrhythmia ndi angina pectoris. Statins imachepetsa mphamvu ya cholesterol yobwezeretsa thupi.

Zipsera za arterial zimakhala ndi cholesterol, ndipo ngati zowonongeka ndi mapuloteni ophatikizana ndi ma acid, zimathetsa chisokonezo.

Kuti muwonetsetse kukula kwa minofu ndikugwira ntchito kwakuthupi koyenera, mumafunikira LDL "yoyipa" yomweyo, komanso chifukwa cha kupweteka kwake kumbuyo ndi minofu, yomwe nthawi zambiri imadandaula ndi odwala omwe amamwa mankhwala a statin.

Cholesterol imapangidwa kuchokera ku mevalonate, komanso imapanga zinthu zina zothandiza, popanda matenda akulu omwe amapezeka. Mwakutero, kupanga kwake kumachepetsedwa ndi ma statins. Amatsogoleranso kukulitsa matenda a shuga, pali kuchuluka kwa cholesterol, pamakhala chiopsezo cha ischemia, stroke komanso kusokonezeka kwa dongosolo la mtima.

Zotsatira zoyipa za ma statins ndizowopsa.Amayamba kuvutika chifukwa cha munthu, zimakhudza ntchito yake ya muubongo, makamaka okalamba.

Kuchitapo kanthu kwakanthawi pazinthu zachilengedwe kumabweretsa mavuto omwe nthawi zina sangakonzeke. Ngati munthu wazaka zopitilira 50 ali ndi cholesterol yayikulu, ichi ndi chizindikiro cha kukhalapo kwa zovuta zazikulu - matenda, kutupa, matenda am'mimba, kulephera kwa kagayidwe kazakudya.

Kwa cholesterol palokha siyoyambitsa matenda, koma chisonyezo cha mkhalidwe wa munthu wathunthu. Izi zikutanthauza kuti kumenya ndi kuteteza thupi, ndipo sikuti kumabweretsa thanzi labwino. Ndipo choyamba muyenera kuyang'ana zomwe zikuyambitsa, kenako yang'anani ndi zomwe zimayenderana ndi izi kapena kuphwanya kumeneku.

M'malo mwa Statin

Pofuna kuchepetsa mlingo komanso kuchepetsa kuwonongeka kwa mgwirizano, akatswiri a mtima amatenga ma fupa - njira yina ya ma statins. Kulandilidwa kwa ma fibrate kumapangitsa kuchepa kwa zowonjezera zowonjezera ndi 20%. Koma amakhalanso ndi zotsatira zoyipa zomwe zimayambitsa dyspepsia, flatulence, nseru, kufooka, kutsegula m'mimba, kupweteka kwamutu, potency, venous thromboembolism, ndi chifuwa.

Mafayilo amaphatikizapo Lipantil, Exlip, Tsiprofibrat - Lipanor, Gemfibrozil.

Pakati pazithandizo zachilengedwe zomwe zimathandiza kulimbana ndi cholesterol yayikulu, pali izi:

omega 3, resveratrol, yomwe ndi gawo la Transverol,
lipoic acid
mafuta opindika
zakudya zamafuta ambiri
ascorbic acid
adyo
nsomba yamafuta, mafuta a nsomba,
turmeric
Sipani yochokera ku nzimbe, yomwe imayang'anira kuthamanga kwa magazi.

Zachidziwikire, njira yofananira imakhala yotsika ndi mankhwala opangira mankhwala, koma mofatsa, mwanjira yachilengedwe, popanda kuvulaza, zimathandiza kubwezeretsa mawonekedwe a magazi kukhala abwinobwino. Anthu ambiri samakana zabwino za kusala kudya, kutenga ma decoctions ndi infusions kuchokera maphikidwe a mankhwala achikhalidwe.

Njira yochepetsera cholesterol yamagazi imaphatikizapo:

Owerenga athu adagwiritsa ntchito bwino Aterol kutsitsa cholesterol. Kuwona kutchuka kwa malonda, tidaganiza zoperekera chidwi chanu.

zakudya zoyenera
kupewa kusuta
kukhala ndi moyo wabwino.

Kuchita masewera olimbitsa thupi, kudya zakudya zabwino komanso kuthetsa zizolowezi zoipa kumathandizira kuti pakhale zotsatira zabwino komanso kubweretsa zabwino zenizeni, ndipo kugwiritsa ntchito mankhwala omwe ali ndi zotsatirapo zoyipa kumayang'aniridwa.

Kodi mwakhala mukuvutitsidwa kwanthawi yayitali ndimutu, migraines, kupuma movutikira pang'ono, komanso kuphatikiza zonsezi zotchulidwa HYPERTENSION? Kodi mukudziwa kuti zizindikiro zonsezi zimawonetsa kuchuluka kwa cholesterol m'thupi lanu? Ndipo zomwe zimafunika ndikubwezeretsanso cholesterol.

Poona kuti mukuwerenga izi tsopano - kulimbana ndi matenda alibe kumbali yanu. Ndipo tsopano yankhani funsolo: kodi izi zikuyenera inu? Kodi zizindikiro zonsezi zingathe kuloledwa? Ndipo ndi ndalama ndi nthawi yochuluka bwanji zomwe "mudathira" kale pachipatala cha SYMPTOM, osati za matendawo omwe? Kupatula apo, ndikulondola kwambiri kupewetsa osati chizindikiro cha matendawa, koma matendawo omwe! Kodi mukuvomera?

Ichi ndichifukwa chake tikukulimbikitsani kuti muzolowere njira yatsopano ya E. Malysheva, yemwe adapeza chida chothandiza pantchito YOPHUNZITSA cholesterol yayikulu. Werengani mafunso ...

Zizindikiro zochepetsera cholesterol mu shuga

Ma Statin ndi shuga - kuvulaza kapena kupindula? Vutoli limapangitsabe mikangano pakati pa madokotala ndi asayansi. Kugwiritsa ntchito ma statins ngati njira yolepheretsera matenda a mtima ndi odwala omwe ali ndi matenda ashuga kumathandizira kukulira chiyembekezo cha moyo kwa odwala. Komabe, pakuyesa kwa mankhwalawa zamankhwala a gululi, zidapezeka kuti kugwiritsa ntchito kwawo nthawi yayitali kumawonjezera kuchuluka kwa shuga wamagazi ndikuwonjezereka kwa odwala omwe ali ndi zizindikiro za matenda ashuga.

Komabe, mapindu akugwiritsa ntchito ma statins amapitilira chiwopsezo cha zovuta zina chifukwa chomwa mankhwalawa.Kwa odwala matenda a shuga, kuchuluka kwa lipids m'magazi kuli kakhalidwe, chifukwa chake, odwala awa amapanga gulu lowopsa la matenda a mtima ndi mtima. Muzochitika zamankhwala, kuperekedwa kwa ma statins amtundu wa 2 shuga ndiye njira yayikulu yothandizira.

Kukula cholesterol mu shuga

Cholesterol m'thupi ndiyofunikira ndipo imagwira ntchito zotsatirazi:

ndimanga zipupa
Kupanga Vitamini D
kapangidwe ka mahomoni ogonana,
kapangidwe ka michere yamitsempha,
kupanga bile acid.

Zambiri mwa zinthu zotere zimapangidwa ndi thupi lokha, 20% yokha imachokera ku chakudya. Koma cholesterol iyenera kukhalapo mu thupi la munthu zochuluka.

Kuchulukitsa kumabweretsa kuti cholesterol yowonjezera imadziunjikira pamakoma amitsempha yamagazi, ndikupanga zolembera. Izi zimabweretsa kukulitsa kwa atherosulinosis, kuchepetsedwa kwa lumen ya bedi lamitsempha komanso kuthamanga kwa magazi. Kusintha koteroko nthawi zambiri kumayambitsa stroko komanso mtima.

Odwala omwe ali ndi matenda ashuga, magazi amadzaza ndi shuga ndi ma free radicals. Kuphatikizika koteroko kumakhudza mkhalidwe wamatayala: amakhala osalimba, ndipo makoma amatenga mawonekedwe. Mu ma microcracks omwe amadza chifukwa, cholesterol imakhazikika, yomwe imasonkhana nthawi yayitali. Chifukwa chake, ndikofunikira kuti odwala matenda ashuga azisamalira lipids yamagazi pafupipafupi kuti achepetse zovuta za mtima. Pankhaniyi, zokonda zimaperekedwa kwa ma statins. Ndiwothandiza makamaka kwa matenda ashuga a 2.

Zochita za statins

Statins ndi gulu la mankhwala omwe amachepetsa cholesterol yamagazi. Amalepheretsa ntchito ya enzyme inayake, yomwe imayang'anira kupanga cholesterol ndi maselo a chiwindi.

Nthawi yomweyo, kapangidwe kake mthupi kamacheperachepera. Zotsatira zake, njira yolipirira imayambitsidwa: cholesterol receptors imakhala yolimba kwambiri ndikumangirira lipids zomwe zilipo, zomwe zimapangitsa kutsika kwakukulu kwambiri pamlingo wake.

Ma Statin ali ndi zotsatirazi zotsatilazi:

Vomerezani kutupa kwamitsempha.
Sinthani kagayidwe.
Minye magazi, kukonza magazi ndi kuteteza mapangidwe a lipid amana.
Mwa njira inayake, kupatukana kozungulira ndi kulowa kwawo pabedi lamitsempha.
Kuchepetsa kuyamwa kwa cholesterol kuchokera ku zakudya.
Amamasuka ndikufinya mitsempha yamagazi pang'ono polimbikitsa kupanga nitric oxide.

Pali gulu la odwala lomwe mankhwalawa amalembera. Izi zimaphatikizapo odwala omwe adakumana ndi vuto la mtima kapena stroko, komanso adakhala ndi matenda ena amtima. Onetsetsani kuti mwapereka mankhwala opatsirana kwa odwala matenda ashuga. Kwa magulu otsala a odwala, popereka mankhwala ochepetsa lipid, phindu ndi kuvulazidwa ndikugwiritsa ntchito ziyenera kuyanjanitsidwa.

Kupereka mankhwala ochepetsa lipid-kwa odwala matenda ashuga

Ubwino wogwiritsa ntchito mankhwala ochepetsa lipid ndiwodziwikiratu ndipo umakhala pochepetsa chiopsezo cha zovuta kuchokera mumtima ndi m'mitsempha yamagazi. Pakugwiritsa ntchito bwino, ma statins amasiyana wina ndi mnzake. Zochitika zikuwonetsa kuti kuchepa kwa lipid kumadalira pazinthu ziwiri:

mtundu wa mankhwala ochepetsa lipid
kuchuluka kwa mankhwalawa.

Ndi ma statins ati omwe ali odziwika kwambiri? Mtsogoleri wowoneka bwino wogwiritsidwa ntchito ndi Rosuvastatin, Atorvastatin ndi Simvastatin ali kumbuyo kwenikweni. Zabwino kwambiri komanso zochepa zoyipa ndizotsatira za m'badwo wotsiriza - Atorvastatin (mankhwala Atoris, Liprimar, Tulip, Torvakard) ndi Rosuvastatin (ndalama Krestor, Rosucard, Akorta, Mertenil).

Lemberani mankhwala a shuga atatu

Mtundu wamatendawa umadziwika ndi chiopsezo chachikulu chotenga mtima ischemia. Mitundu yokhala ndi matenda a shuga 2 imatengedwa bwino kwambiri ngati matenda a mtima sanawonekere, kapena kuchuluka kwa cholesterol kumakhala kovomerezeka.Izi zimathandizira kukulira chiyembekezo cha moyo.

Kupenyetsetsa kwawonetsa kuti kuchuluka kwa mankhwala omwe amathandizadi pochiza matenda amtundu wa 1 siothandiza kwenikweni kwa odwala omwe ali ndi matenda a shuga a 2. Chifukwa chake, pochiza odwala chotere, mulingo wovomerezeka wa mankhwalawa umagwiritsidwa ntchito. Ndikofunikira kudziwa kuti mtundu wa 2 matenda a shuga ndizovuta kuchiza, ndipo kuti mukwaniritse zomwe mukufuna, muyenera kumwa mankhwalawa kwa nthawi yayitali.

Anna Ivanovna Zhukova

Sitemap

Openda magazi
Amasanthula
Atherosulinosis
Mankhwala
Chithandizo
Njira za anthu
Chakudya chopatsa thanzi

Komabe, mapindu akugwiritsa ntchito ma statins amapitilira chiwopsezo cha zovuta zina chifukwa chomwa mankhwalawa. Kwa odwala matenda a shuga, kuchuluka kwa lipids m'magazi kuli kakhalidwe, chifukwa chake, odwala awa amapanga gulu lowopsa la matenda a mtima ndi mtima. Muzochitika zamankhwala, kuperekedwa kwa ma statins amtundu wa 2 shuga ndiye njira yayikulu yothandizira.

Ubwino Liprimar kapena Crestor wa thupi ndi chiyani?

Imakhazikika pamisempha ya shuga kwa nthawi yayitali
Zimabwezeretsa kupanga kwa insulin

Cholesterol chambiri nthawi zonse chimakhala ndi zotsatirapo zoipa ngati chithandizo sichikuyamba pa nthawi. Ngati mankhwalawa ali munthawi zonse, amangothandiza.

Kusamala kwa mitundu iwiri ya cholesterol ndikofunikira: milomo yayikulu ya lipoprotein ndi lipoproteins yotsika. Ngakhale ndizofunikira, kusiyana kwawo kumagona kuti LDL yowonjezereka imakhala yovulaza thupi lonse, chifukwa madongosolo ochulukirapo amakhazikika pamakoma amitsempha yamagazi, pambuyo pake cholesterol malo amawonekera - kuyamba kwa atherossteosis. HDL, ngakhale yochuluka kwambiri, imathandiza thupi, chifukwa imatha kupewa matenda a mtima ndikuchepetsa cholesterol "yoyipa".

Mu malingaliro, zonse ndizosavuta. Koma mchitidwewu umatsimikizira kuti anthu samayang'anira thanzi lawo, ndipo amatembenukira kumabungwe azachipatala chifukwa cha kuwonongeka kwake konse ndi kupweteka kosalekeza. Momwemo ndi cholesterol, chifukwa palibe zizindikiro za kukomoka.

Zimachitika kuti nthawi zambiri, kuphwanya kumapezeka kumapeto. Kenako akatswiri amalimbikitsa njira zingapo zochiritsira, kuphatikizapo kumwa mankhwala apadera. Zina mwazomwe muli monga Krestor ndi Liprimar. Statin amatha kuchepetsa kuchuluka kwa LDL munthawi yochepa. Koma, nthawi zambiri, chifukwa cha zochitika, odwala amafunsa funso: Kodi liprimar kapena Krestor ndi chiyani? Kuti mudziwe yankho, muyenera kuphunzira mosamala za momwe mankhwalawo amagwirira ntchito.

Krestor kapena Liprimar: ndizabwinonso ndipo ndizotheka kumwa mankhwala mosalekeza?

Kugwiritsa ntchito ma statins mu shuga

Cholinga chachikulu choperekera mankhwala kuchokera ku gulu la statin kwa odwala omwe ali ndi matenda a metabolic kapena matenda a shuga ndikuletsa kukula kwa mtima ndi matenda amitsempha, kapena kupewa zovuta kwa omwe adapezeka kuti ali ndi matenda a mtima. Mu nkhani yoyamba, tikulankhula za kupewa koyambirira, chachiwiri, motsatana, - chachiwiri. Pomaliza, kulowererapo kuyenera kuthandizira kuchuluka kwa moyo wa odwala.

Komabe, posachedwa, asayansi aku America adapanga lingaliro lokhumudwitsa, lomwe lidatengera zotsatira za mayeso azachipatala:

Chenjezo kuchokera kwa asayansi aku America:

Pokonzekera kuthana ndi matenda osiyanasiyana, mankhwala ena amatha kuvulaza thanzi lanu.Mwakutero, ma statins odziwika bwino omwe amapangidwa kuti achepetse cholesterol ndi triglycerides m'magazi, akagwiritsidwa ntchito waukulu, angayambitse matenda a shuga.

Kodi izi zilidi choncho? Nkhaniyi pakadali pano ikukambirana. Pakadali pano, mawu otsatira ndi awa: inde, kuchuluka kwambiri kwa ma statins kungakulitse chiopsezo chotenga matenda a shuga ndi 12%. Komabe, palibe chifukwa chodera nkhawa, popeza maubwino a mankhwalawa ndi ochulukirapo kuposa mavuto.

Mwanjira ina, ngati pali zifukwa zomveka zotengera mankhwalawo ku gulu la ma statins, ndiye kuti simuyenera kunyalanyaza izi.

Masiku ano, madokotala akuda nkhawa kwambiri ndi vuto lakukana wodwala kudya ma statin chifukwa cholengeza zotsatira izi. Zinapezekanso kuti chiwopsezo chachikulu kwambiri pokhudzana ndi chitukuko cha matenda ashuga chimanyamula kudya kwa atorvastatin. Kugwiritsa ntchito mankhwala ena kuchokera ku gulu la ma statins kulibe owopsa.

Siyani ndemanga ndikupeza MPHATSO!

Gawani ndi abwenzi:

Werengani zambiri pamutuwu:

Mfundo za glucometer
Maupangiri a Thanzi la a shuga
Kodi ndi mfundo ziti zomwe muyenera kuyesetsa kuti muchepetse matenda ashuga? Mukuyang'ana malo apakati ...

Pharmacological zochita za mankhwala

Crestor ndiye woyamba mankhwala a rosuvastatin, wopanga - United Kingdom. Chofunikira kwambiri ndi calcium rosuvastatin, wopangidwa ndi: crospovidone, calcium phosphate, magnesium stearate, lactose monohydrate. Kuchita kwake ndikulinga kutsitsa mulingo wa lipoprotein wotsika kwambiri. Zimadziwika kuti ndizothandiza kwambiri, mosiyana ndi mankhwala enanso. Akatswiri nthawi zambiri amapereka mankhwala ngati pali vuto lalikulu la matenda a mtima. Mankhwalawa ali ndi izi:

otsika LDL
Imachepetsa ndende ya triglyceride,
amachepetsa kuchuluka kwa lipoproteins otsika kwambiri,
amathandizira kutukusira kwa mtima,
Amasintha magwiridwe antchito a protein-C.

Zotsatira zakuyesa magazi zimatha kuyenda bwino m'milungu iwiri yokha, ndipo zotsatira zake zimakhala zambiri mwezi umodzi. Krestor amalumikizana ndi mankhwala ena bwino kwambiri kuposa mankhwala ena omwe ali mgululi.

Mavuto amatha kuchitika mogwirizana ndi othandizira omwe amakhudza chitetezo cha mthupi, maantibayotiki, njira zakulera, zopewera magazi. Kuchita ndi mankhwalawa kungayambitse matenda a impso ndi chiwindi. Chifukwa chake, mankhwala aliwonse ayenera kuvomerezana ndi adokotala. Ndikofunikira kufotokozera nthawi zonse ndalama zomwe wodwala amatenga.

Liprimar ndi mankhwala enieni a atorvastatin opangidwa ku Germany. Ngakhale kuti mankhwala ofanana ambiri amagulitsidwa ndi chinthu ichi, mankhwalawa amadziwika kuti ndi abwino kwambiri.

Inde, ndiotsika mtengo, koma kugwira ntchito kwawo kumakhala kotsika kambiri. Gawo lalikulu ndi atorvastatin, lili ndi lactose monohydrate, crosscarmellose sodium, calcium carbonate, magnesium stearate, polysorbate 80, stearic emulsifier, hypromellose. Mankhwalawa amakhudza cholesterol ndi triglycerides. Mwambiri, imakhudzanso thupi:

otsika okwana mafuta m'thupi
otsitsa LDL cholesterol,
amachepetsa kuchuluka kwa apoliprotein,
otsika pamtengo
kumawonjezera kuchuluka kwa HDL.

Mankhwala amalumikizana bwino ndi mankhwala ambiri. Ndibwino kuti musagwiritse ntchito mankhwalawa limodzi ndi maantibayotiki, anti-fungal drug, motsutsana ndi matenda oopsa, kulephera kwa mtima, ndi mankhwala omwe amachepetsa magazi.

Ngati mukumwa mankhwalawa osakudziwitsa adotolo, muyenera kulumikizana ndi achipatala kuti akuthandizeni.

Kodi mungatani kuti muchepetse cholesterol?

Cholesterol yayikulu m'magazi imawonedwa mwa anthu omwe ali ndi thupi lalikulu, akuvutika ndi cholowa chokhala ndi chibadwa ndipo amatenga, kukhala ndi vuto la mtima kapena stroko, kapena omwe ali poyandikira mawonekedwe awo.

Kupewa matenda amtima kumathandizira kuti muchepetse mafuta m'thupi. Amamuthandizira kuti athetse mankhwalawa kuchokera pagulu la ma statin opanga. Amakhudzanso kuchuluka kwa cholesterol m'magazi, komanso triglycerides, chifukwa chake, ali ndi zovuta za hypocholesterolemic ndi lipid-kuchepetsa thupi la wodwala. Amathandizira kutukusira kwa mtima, kumachepetsa magazi, omwe amalepheretsa magazi kuundana, potero amaletsa kukula kwa matenda a mtima, stroko, ndi atherosclerosis.

Gulu la mankhwalawa limaphatikizaponso mankhwala odula a ku Germany, Liprimar. Chifukwa chake, phukusi la mapiritsi 100 a iwo amatengera ma ruble 1,500. Popeza mankhwalawa amawerengedwa kwa odwala kuti azidya pafupipafupi tsiku lililonse popanda zosokoneza, mtengo uwu umakhudza kwambiri ndalama za pabanja. Chifukwa chake, ambiri ali ndi chidwi chogwiritsa ntchito analogue yotsika mtengo ya Liprimar.

Kutsika pang'ono timaganizira zakumwa kwa mankhwalawa ndi zina zofananira, zomwe mungasankhe zotsika mtengo. Koma timangoyang'ana mwachangu kuti mankhwala otsika mtengo samatsimikizira kuti mankhwalawa amathandizika, makamaka kwa mankhwala ochokera ku India.

Mankhwala "Liprimar": mawonekedwe, katundu, malangizo ogwiritsira ntchito

Musanasankhe m'malo mankhwalawa, muyenera kudziwa zonse za mankhwalawa, zomwe zikufotokozedwa mu malangizo ogwiritsira ntchito mankhwala a Liprimar. Ma analogs amayeneranso kukhala nawo kapena kukhudza thupi la wodwalayo chimodzimodzi.

Kuphatikizika kwa mankhwalawa kumaphatikizapo zinthu zomwe zimagwira atorvastatin ndi zigawo zothandizira: calcium carbonate, magnesium stearate, croscarmellose sodium, hypromellose, lactose monohydrate, hydroxypropyl cellulose, titanium dioxide, talc, simethicone emulsion.

Kutulutsidwa kwa mankhwalawa ndi mapiritsi okhala ndi zosakaniza 10 mg, 20 mg, 40 mg, 80 mg. Mankhwalawa samangoleketsa kuchuluka kwa cholesterol m'mwazi, komanso kapangidwe kake m'chiwindi. Tiyenera kudziwa kuti mankhwala a Liprimar amatsitsa zomwe zimadziwika kuti cholesterol yoyipa (LDL) ndikuwonjezera zabwino (HDL).

Amawerengedwa kuti ndiwopamwamba kwambiri pakati pa mankhwala ambiri ochokera pagulu la ma statins, kotero kugwiritsidwa ntchito kwake kumachepetsa kuchuluka kwa cholesterol m'magazi ndi 60%. Izi ndi zotsatira zabwino za machitidwe a mankhwalawa.

Kugwiritsa ntchito bwino kwa mankhwalawa sikukhudzidwa ndi chakudya, chifukwa chake chitha kutengedwa musanayambe kudya. Kutalika kwa piritsi limodzi ndi maola 30.

Mlingo womwe waperekedwa ndi wa wodwala aliyense. Nthawi zambiri, mankhwala amayamba piritsi la 10 mg. Ngati ichita chofooka, ndiye kuti mlingowo ukuwonjezeka. Malingaliro a cholesterol a ana, amuna, akazi, okalamba amasiyananso, motero, mulingo wina umagwiritsidwa ntchito pa mankhwala awo.

Kumwa mankhwala a Liprimar (ma analogues nawonso ali m'maganizo) kuyenera kumayendetsedwa ndi chakudya, kayendedwe kogwira, izi ndizowona makamaka kunenepa kwambiri. Chida ichi ndi chothandizira pamoyo wathanzi.

Muyenera kudziwa kuti mankhwalawa amathandizira kuwonjezera shuga m'magazi a anthu odwala matenda ashuga, komabe, amagwiritsidwa ntchito kuopseza matenda a mtima. Izi mwina ndizokhazo zomwe zimapangitsa kuti musamwe mankhwalawo.

Mankhwala "Lymprimar" amathandizira kupitiriza kwa moyo wa anthu omwe ali ndi matenda amtima kapena pachiwopsezo cha kukula kwawo.

Ndani amamuika mankhwalawo?

Mankhwala a Liprimar (fanizo la statin iyi, nawonso) amapatsidwa cholesterol yayikulu kwa achikulire ndi achinyamata omwe amapezeka ndi hypercholesterolemia, komanso zolinga zopewetsa matenda oyamba ndi obwereza mtima, atherosclerosis, ndi ischemic stroke.Gulu lowopsa lachiwonetsero cha zovuta zamtima zimaphatikizira anthu omwe ali ndi matenda amitsempha yamagazi, matenda oopsa, matenda a shuga omwe amachitidwa opaleshoni kuti abwezeretse magazi m'mitsempha yokhala ndi vuto la atherosulinosis.

Contraindication

Kupereka mankhwalawa kwa amayi apakati, amayi oyamwitsa, anthu omwe ali ndi matenda owopsa a chiwindi saloledwa. Komanso, mankhwalawa samatengedwa ndi tsankho pazinthu zomwe zimapangidwa. Mosamala, chithandizo ndi wothandizirayi chikuchitika ndi kuchepa kwa mahomoni a chithokomiro, uchidakwa, matenda a shuga, matenda oopsa, matenda oopsa.

Zogwiritsa Ntchito Mankhwala Osokoneza bongo

Ngati mungasankhe analogue ya Liprimar, malinga ndi kapangidwe kake ndi momwe thupi limadziwira, mutha kuyang'ana m'malo motengera izi: mankhwala a Atomax (ma ruble 360), mapiritsi a Atorvastatin (ma ruble 127), mankhwala a Canon (650 rubles) , mankhwala "Atoris" (604 ma ruble), statin "Torvakard" (1090 rubles), mankhwala "Tulip" (300 ma ruble), mapiritsi "Liptonorm" (400 ma ruble).

Umboni wa akatswiri amtima okhudzana ndi ma statins amalimbikitsa kuti m'malo mwa Torvacard (opangidwa ku Czech Republic) ndi Atoris (wopangidwa ku Slovenia) asankhidwe mndandandandawo.

Mankhwala ena otsika mtengo, monga Liprimar (analogues), amafotokozedwa ndi odwala ngati njira zomwe zimayambitsa zovuta zina. Ngakhale mankhwalawa enieniwo samayambitsa vuto lililonse, kupatula milandu yachilendo.

Tiyeneranso kudziwa kuti m'malingaliro a akatswiri a mtima nthawi zambiri pamakhala lingaliro kuti ndibwino kuti asatenge Liprimar, analogues (Atorvastatin) waku Russia. Izi zikuphatikiza ndi mapiritsi a Liptonorm.

Mankhwala "Rosulip"

Analogue ya Liprimar amathanso kusankhidwa kuchokera pagulu la mibadwo ya mibadwo yachinayi. Awa ndimankhwala omwe amachepetsa kwambiri cholesterol. Amawerengedwa ngati kuphatikiza kopitilira muyeso ndi chitetezo. Ngakhale madotolo amawona zabwino zawo monga kuthana ndi vuto la impso komanso kuwonjezeka kwa shuga m'magazi.

Ndizosatheka kunena kuti fanizo la mankhwala a Liprimar ochokera pagululi la mankhwala ndizosatheka. Amagwiritsidwa ntchito poyenda chimodzimodzi. Inde, kwa wodwala aliyense, amapatsidwa mankhwala ena, omwe amachititsa kuti azikhala osasangalala panthawi ya chithandizo.

Ma statin a m'badwo wachinayi samaphatikizapo atorvastatin, koma yogwira element rosuvastatin. Ngati mankhwala okhala ndi oyambawa adafufuzidwa bwino, ndiye kuti mankhwala omwe ali ndi yachiwiri sanaphunziridwe kwathunthu. Komabe, amagwiritsidwa ntchito kwambiri muzochitika zamankhwala zamankhwala.

Analogue yotsika mtengo ya Liprimar kuchokera ku gulu la mibadwo yachinayi ndi mankhwala a Rosulip. Amawononga ma ruble 900. Mankhwalawa, mosiyana ndi mankhwala a Limprimar, samalimbikitsidwa pochiza ana ndi achinyamata. Amalembera okhazikika komanso cholowa hypercholesterolemia, pofuna kupewa kupita patsogolo kwa atherosulinosis, komanso kupewa mikwingwirima ndi matenda a mtima mwa odwala omwe alibe IHD, koma adatsimikizika pakukula kwake.

Osafunika mankhwalawa amayi oyembekezera komanso akakhanda, komanso odwala omwe ali ndi matendawa chifukwa cha rosuvastatin. Zosagwiritsidwa ntchito kwa anthu omwe ali ndi matenda a impso ndi chiwindi.

Zingayambitse kusokonezeka m'mimba - kupweteka, colic, kudzimbidwa, kuiwalika, kupweteka mutu, chifuwa, kufupika, kusokoneza chithokomiro.

Malingaliro a odwala zokhudzana ndi mankhwalawa amasakanikirana. Iwo omwe amasintha kuti agwiritsidwe ntchito ndi Liprimar mankhwala akuti palibe kusiyana kwapadera. Ndipo omwe amagwiritsa ntchito mankhwala a "Rosulip" okha, amakana kuwonjezeka kwa shuga m'magazi mukamalandira nawo mankhwalawo.

Mankhwala "Crestor"

Analogue ya Liprimar (m'malo mwake) kuchokera pagulu la mankhwala omwe ali ndi rosuvastatin m'mapangidwe ake amathanso kukhala okwera mtengo. Mwachitsanzo, mankhwalawa "Crestor" amatenga ma ruble 1,500.Akatswiri ambiri a mtima ndi odwala omwe adziwona zotsatira zake pawokha amachitapo kanthu poyenda.

Amayika ngati pakufunika kuchepetsa njira ya atherosulinosis, cholowa ndi chosakanizira cha hypercholesterolemia. Zitha kuyambitsa chizungulire, kuyabwa pakhungu, kupweteka mutu, kuyambitsa matenda a shuga.

Zosagwiritsidwa ntchito kwa anthu omwe ali ndi matenda a impso ndi chiwindi.

Mankhwala "Simgal"

Mankhwala a Liprimar sagwiritsidwa ntchito nthawi zonse kutsitsa cholesterol. Mndandanda wa mankhwalawa kuchokera ku gulu la statins a m'badwo woyamba nawonso amalimbana ndi ntchitoyi. Awa ndimankhwala okhala ndi zosakaniza zachilengedwe, koma sayenera kuonedwa ngati otetezeka. Amathanso kuyambitsa mavuto.

Mankhwala "Simgal" kuchokera pagululi atha kusintha mankhwala "Liprimar". Zimakhala zotsika mtengo pang'ono - ma ruble 1300. The yogwira mankhwala ali zikuchokera, wofanana atorvastatin - simvastatin. Amalandira ngati matenda a mtima, oyamba komanso chibadwa cha hyperlipidemia.

Anthu omwe sanamvepo za mibadwo ya ma statins, malinga ndi malingaliro awo, amasankha mankhwala kuchokera pagulu lachitatu komanso lachinayi la mankhwalawa kuti athandizidwe, powaganizira kuti ndi angwiro komanso otetezeka. Koma madokotala akuti palibe ma statins otetezeka. Zachilengedwe komanso zopangidwa zimayambitsa mavuto akulu, motero amasankha mankhwala kwa wodwala aliyense payekhapayekha.

Mankhwala "Zokor"

Mankhwala monga Zokor, omwe amakhalanso ndi simvastatin, atha kukhala m'malo abwino a Liprimar. Mtengo wake ndi ma ruble 800. Odwala komanso azamankhwala onse amalabadira izi. Zitha kubweretsa zolakwika monga mutu, zotupa za m'mimba, kukokana kwa minofu, khungu loyabwa, kufupika.

Kutanthauza "Simvastol"

Mankhwalawa amathanso kusintha mankhwala "Liprimar", amaphatikiza simvastatin. Amawononga ma ruble 400. Ndi malingaliro a akatswiri pamalo otsika mtengo, mumawerengera pamwambapa.

Kumbali yabwino, mankhwala a Liprimar amadziwika ndi malangizo ogwiritsira ntchito, ndemanga. Mankhwala a mankhwalawa samalimbikitsidwa nthawi zonse, koma, kuti apulumutse, amagwiritsidwa ntchito pochiza odwala omwe ali pachiwopsezo cha matenda oyamba kapena obwereza.

Mankhwala "Simvastol" angayambitse kupweteka kwa mutu, kukokana, mavuto a kukumbukira, kupweteka kwa minofu, kuchepa kwa potency, nyamakazi, kuchepa kwa magazi, kuchepa kwaimpso.

Ngakhale pali mndandanda waukulu wama statins osinthika, adokotala okhawo ndi omwe ayenera kulandira mankhwala mosamalitsa, kudziwa mtundu womwewo kwa wodwala wina.

Liprimar ndi mankhwala osokoneza bongo omwe amachepetsa cholesterol yamagazi. Kumwa mankhwalawa kumachepetsa chiopsezo cha matenda oopsa a mtima, kumachepetsa mphamvu ya mtima ndikuwongolera mtima.

Odwala omwe amamwa mankhwalawa adazindikira kugwira ntchito kwake komanso kudalirika kwake, ngakhale kuti mtengo wokwera suupangitsa kuti azitchuka.

Liprimar: Zizindikiro zogwiritsidwa ntchito

Mankhwala amathandizidwa ndi matenda otsatirawa:

Mutha kutsitsa cholesterol, kuwona kadyedwe, maphunziro olimbitsa thupi, kunenepa kwambiri mwa kutaya thupi owonjezera, ngati izi sizipereka zotsatira, perekani mankhwala omwe amachepetsa cholesterol.

Ndikofunikira kutsatira malangizo ogwiritsira ntchito Liprimar. Palibe malire a nthawi oti amwe mapiritsiwo. Kutengera ndi zomwe zikuwonetsa LDLP (cholesterol yoyipa), mlingo wa tsiku ndi tsiku wa mankhwalawa (nthawi zambiri 10-80 mg) umawerengeredwa. Wodwala yemwe ali ndi mawonekedwe oyamba a hypercholesterolemia kapena kuphatikiza hyperlipidemia ndi mankhwala 10 mg, omwe amatengedwa tsiku lililonse kwa masabata 2-4. Odwala akudwala cholowa hypercholesterolemia ndi mankhwala okwanira 80 mg.

Sankhani Mlingo wa mankhwala omwe amakhudza metabolism yamafuta ayenera kuyang'aniridwa ndi milingo ya lipid m'magazi.

Mochenjera, mankhwalawa amalembedwa kwa odwala omwe ali ndi vuto la chiwindi kapena chikugwirizana ndi cyclosparin (osapitirira 10 mg patsiku), akuvutika ndi matenda a impso, odwala omwe ali ndi zaka zochepetsedwa Mlingo safunika.

Kupanga ndi mawonekedwe a kumasulidwa

Wopezeka mu mawonekedwe a mapiritsi, m'matumba a zidutswa za 7-10, kuchuluka kwa matuza omwe ali phukusili ndizosiyana, kuyambira 2 mpaka 10. Chomwe chimagwira ndi mchere wa calcium (atorvastatin) ndi zinthu zina zowonjezera: croscarmellose sodium, calcium carbonate, wax hyprolose, lactose monohydrate, polysorbate-80, oyera opadra, magnesium stearate, simethicone emulsion.

Mapiritsi a Elliptical Liprimar atakulungidwa ndi chipolopolo choyera, kutengera mlingo wa milligram, ali ndi zolemba za 10, 20, 40 kapena 80.

Zothandiza katundu

Chuma chachikulu cha Liprimar ndi hypolipidemia. Mankhwala amathandizira kuchepetsa kupanga ma enzyme omwe amachititsa kuti mafuta azigwiritsa ntchito cholesterol. Izi zimabweretsa kuchepa pakupanga cholesterol ndi chiwindi, motero, mulingo wake m'magazi umachepa, ndipo ntchito yamtima imayenda bwino.

Mankhwalawa amalembedwa kwa anthu omwe ali ndi hypercholesterolemia, zakudya zosachiritsika komanso mankhwala ena ochepetsa mafuta m'thupi. Pambuyo popita kuthandizira, kuchuluka kwa cholesterol kumatsika ndi 30-45%, ndi LDL - ndi 40-60%, ndipo kuchuluka kwa lipoprotein m'magazi kumachuluka.

Kugwiritsa ntchito Liprimar kumathandizira kuchepetsa kukulitsa kwa matenda a mtima a coronary ndi 15%, kufa kwa mtima kuchokera ku mtima kumachepa, ndipo chiwopsezo cha kugunda kwamtima ndi kuwopsa kwa angina chikuchepera ndi 25%. Katundu wa Mutagenic ndi carcinogenic sanapezeke.

Zotsatira zoyipa

Mothandizidwa ndi mankhwala a Liprimar, kuchuluka kwa cholesterol yomwe imapangidwa imachepetsedwa, yomwe imayambitsa ma LDL receptors, omwe, akayamba kugwira ntchito, amayamba kusaka ma lipoproteins otsika kwambiri, kuwagwira ndikuwanyamula kuti awataye.

Mankhwala oyamba amapangidwa m'mafakitale ku mayiko: USA, komanso ku Europe - Germany ndi Ireland.

Ma analogues a mankhwalawo, komanso ma jini ake, amapangidwa ndi opanga mankhwala m'mayiko ambiri padziko lapansi, komanso pali analog yaku Russia ya Liprimar.

Chaka chilichonse, matenda a atherosclerosis amayamba kuchepa, ndipo amuna atatha zaka 40 amapeza matendawa.

Liprimar ndi a gulu la statins a m'badwo wachitatu, kotero mankhwalawa amayamba bwino ndipo amakhala ndi zovuta zochepa mthupi.

Koma kutengera mtundu wa wodwalayo, momwe angapangire wopangidwayo, wopangirayo adayambitsa zovuta zonse zomwe zingachitike:

Arrhasmia yamimba,
Pathology phlebitis,
Kuchuluka kwa kuchuluka kwa magazi,
Kuvulala pachifuwa
Mtima palpitations - tachycardia,
Kutaya kwathunthu kapena pang'ono pang'ono
Kuphwanya kwam'mimba,
Kusokonezeka m'matumbo - matenda otsekula m'mimba, kapena kudzimbidwa,
Amachepetsa libido mwa akazi komanso kusowa kwa amuna,
Matenda a urination amachitika
Kusokonezeka m'maselo aubongo kumachitika - kukumbukira kumalephera,
Luntha la wodwala limachepa,
Zowawa m'mutu
Kuzungulira m'mutu
Kusowa tulo, kapena kugona.
Kutopa kwa thupi,
Ululu mu minofu minofu.

Panthawi imeneyi, ndi dokotala yekhayo amene angadziwe chomwe chimateteza thupi, cholesterol index, kapena index ya glucose, ndikusintha ndi mankhwala ena a gulu la statin.

Kutulutsa mawonekedwe, zikuchokera

Mankhwala amagulitsidwa monga mapiritsi okhala ndi tulo. Mankhwala "Atoris", mtengo womwe umatsika poyerekeza ndi ma analogues ena, ali ndi chinthu chogwira ntchito chotchedwa atorvastatin calcium, ndipo zinthu zotsatirazi ndi zinthu zothandiza: sodium lauryl sulfate, povidone, lactose monohydrate, cellulose, talc, titanium dioxide,

Mapiritsi omwewo ndi oyera, ozungulira, biconvex.

Mankhwala "Atoris" amapezeka pama mapiritsi atatu. Izi ndi 10, 20 ndi 40 mg.Wogulitsidwa mumakatoni, ndi mapiritsi omwe amaikidwa m'matumba a chithuza. Kutalika kwa makatoni: 10, 30 ndi 90 mapiritsi "Atoris" (malangizo ogwiritsira ntchito).

Zomwe zimagwiritsidwa ntchito ndi atorvastatin, cholengedwa cha m'badwo wachitatu. Zinthu zotsatirazi ndi zothandiza: mowa wa polyvinyl, macrogol 3000, talc, croscarmellose sodium, microcrystalline cellulose, lactose monohydrate, povidone, calcium carbonate, sodium lauryl sulfate.

Omwe amathandizira kudziwa mapiritsi ndi kudziwa kuchuluka kwa mayamwidwe a atorvastatin m'magazi. Momwemo, analogue iliyonse yamankhwala a Atoris iyenera kukhala ndi kuchuluka komweko kwa zinthu zomwe zimagwira ndikuwamasulidwa pamlingo womwewo, ndikupanga kufanana kwina m'magazi.

Chotsatira chofunikira kwambiri pakayendetsedwe kake ndikulepheretsa kaphatikizidwe ka cholesterol poletsa kuyambiranso kwa enzyme HMG-CoA reductase. Zotsatira zake ndi kufafaniza kapena kuchepa kwakukulu kwa kapangidwe ka LDL. Kachigawo kameneka ka lipoproteins kamakhumudwitsa atherosulinosis, kamayambitsa kupendekeka kwa khoma komanso kapangidwe kake m'mitsempha ya mtima, ubongo komanso m'munsi. Pamodzi ndi kuchepa kwa LDL, ndende imawonjezeka

Amagwira ntchito yofunikira: kukulitsa kukana kwa membrane kuzinthu zamakina ndi zamankhwala ndikuphatikizira cholesterol mmenemo. Chifukwa chake, HDL imatayidwa, koma siziunjikira cholesterol.

LDL imatsogolera ku kudzikundikira kumbuyo kwa endothelium ya mtima, kukondweretsa atherosulinosis, pomwe lipoprotein yapamwamba kwambiri imachepetsa kuchuluka kwa cholesterol, koma osachotsa pansi pa membrane wamkati mwa chotupa chamtundu wotupa.

Mankhwala Liprimar - dziko lomwe Germany adachokera. Chosakaniza chogwira ndi atorvastatin statin.

Liprimar ndi mtundu wopangira mankhwala womwe umakhudza cholesterol index ya magawo onse komanso triglycerides m'madzi a m'magazi.

Komanso, mankhwalawa ndi prophylactic wabwino kwambiri kuti muchepetse kukula kwa sitiroko ndi ischemia ya mtima - kugunda kwa mtima.

Opanga amapanga mankhwala a Liprimar mwanjira ya mapiritsi okhala ndi mawonekedwe. Kukonzekera kumachitika ndi gawo la gawo lomwe likugwira - 10,0 mamililita, 20.0 mg, 40.0 mg, komanso mlingo waukulu wa atorvastatin - 80.0 mamililita piritsi limodzi.

Komanso, momwe piritsi lililonse limaphatikizira zina:

Calcium calcium
Mg wakuba
Chomwe chimapangidwa ndi croscarmellose,
Hyp Hypellellose
Lactose Monohydrate
Dioxide ya mamolekyulu a titanium,
Talcum ufa,
Simethicone mu emulsion.

Piritsi limodzi ndi maola 24.

Njira zogwiritsira ntchito

Mapiritsi a Statin kutengera zomwe zimapangidwa ndi atorvastatin - Liprimar amapangidwira pakamwa.

Kumwa mapilitsi sikudalira kudya - mutha kumwa musanadye kapena musanadye. Kugwiritsa ntchito bwino kwa mankhwalawa sikukusintha.

M'masiku oyambilira a maphunzirowa, dokotalayo amapereka mankhwala okwanira mamilimita 10.0.

Ngati mulingo wocheperako wodwala, ndiye kuti mapiritsi okhala ndi mlingo waukulu wa atorvastatin angagwiritsidwe ntchito mwa iwo.

M'malo mwake amatha kutengera atorvastatin, kapena kutengera zina. Dokotala wokha ndi amene anganene izi.

Malangizo amomwe angatenge Atoris amatsika kutifotokozere zina. Makamaka, mankhwalawa amatengedwa mu mlingo womwe waperekedwa kamodzi patsiku chakudya chamadzulo musanagone. Mlingo umodzi ukhoza kukhala 10, 20 ndi 40 mg.

Popeza mankhwalawa ndi mankhwala, kufunsa kwa dokotala ndikofunikira kuti mugule. Ndiye amene, atasanthula timagawo ta mbiri ya lipid ndikuwunika kuchuluka kwa cholesterol yamagazi, amatha kutsimikizira mlingo woyenera wa atorvastatin, gulu lake lotengera kapena majini.

Ndi cholesterol yoyambirira ya 7.5 kapena kupitilira, tikulimbikitsidwa kutenga 80 mg / tsiku. Mlingo wofananawo umaperekedwa kwa odwala omwe akuvutika kapena omwe ali ndi nthawi yovuta kwambiri. Pazakudya za 6.5 mpaka 7.5, mlingo woyenera ndi 40 mg.

20 mg amatengedwa pamlingo wa cholesterol wa 5.5 - 6.5 mmol / lita. 10 mg ya mankhwala tikulimbikitsidwa kwa ana 10 zaka 17 ndi heterozygous hypercholesterolemia, komanso akuluakulu omwe ali ndi hypercholesterolemia yoyamba.

Mayankho olakwika a wodwala

Rosuvastatin yatsimikiziridwa kuti ichepetsa chiwopsezo cha matenda a mtima, komanso ischemic stroke, mavuto amiyendo, ndi mawonekedwe ena a atherosulinosis. Mankhwalawa ndi m'gulu la mankhwala otchedwa statins.

Kutupa pakasowa, ma atherosselotic plaques amasiya kukula, ngakhale LDL cholesterol ikadali yokwera. Malingaliro awa adawonetsedwa koyamba munkhani "C-reactive protein ndi zina zolemba za kutupa pakulosera zam'kati mwa azimayi" mu Marichi 2000 New England Journal of Medicine.

Zinadziwika kuti ndi bwino kupereka mapiritsi a rosuvastatin kwa okalamba ndi achikulire omwe ali ndi mapuloteni ambiri a C, ngakhale atakhala ndi cholesterol yokhazikika. Kafukufuku wa JUPITER adawonetsa kuti mwa odwala, rosuvastatin amachepetsa chiopsezo cha kugunda kwamtima, kugunda kwa mtima ndi mavuto ena amtima pafupifupi kawiri.

Krestor anali woyamba komanso pakadali pano statin yokha yolandila chidziwitso kuti agwiritse ntchito. Izi zakulitsa msika wake. Odwala ayenera kudziwa kuti ma statins ena (atorvastatin, simvastatin, lovastatin) amachepetsa kutupa, kusintha mapuloteni a C omwe amathandizira.

Koma ma Patent a mankhwalawa adatha nthawi yayitali. Chifukwa chake, palibe amene adayamba kulipira ndikuyambitsa maphunziro okwera mtengo a anti-kutupa zotsatira za statins zam'badwo wapitawu.

Crestor ndi ena opanga mapiritsi a rosuvastatin amatsitsa cholesterol "choyipa" cha LDL kuposa ma statins akale. Target low LDL cholesterol imafika ku 64-81% ya odwala omwe amamwa mankhwalawa.

Pakati pa anthu omwe amatenga ma statin ena, 34-73%. Funso lina ndikuti zimakhala bwanji. Chiphunzitso chomwe takambirana pamwambapa ndikuti chithandizo chachikulu cha ma statins ndikuchepetsa kutupa. Akatswiri omwe ali ndi malingaliro awa amakhulupirira kuti kutsitsa cholesterol ya LDL ndi zotsatira zoyipa zomwe sizikugwirizana ndi kuchepetsa chiopsezo cha kugunda kwa mtima ndi sitiroko.

Mapuloteni a C-reactive ndi chizindikiro china cha kutupa amafunikira kuyang'aniridwa mosamala kuposa cholesterol. Chithandizo chachikulu chimawerengedwa ngati chakudya komanso zolimbitsa thupi. Musayesere kusintha kusintha kuti mukhale ndi moyo wathanzi ndi mankhwala a Krestor kapena mapiritsi ena aliwonse.

Ngakhale izi, mankhwala am'mibadwo yam'mbuyo amachepetsa cholesterol "yoyipa" chichepera. Ndizoyenera kukumbukira apa kuti LDL cholesterol siyowopsa, koma chinthu chofunikira. Amuna ndi akazi ogonana amapangidwa kuchokera pamenepo, ndikofunikanso ku ubongo.

Kuchepetsa kwambiri “choletsa” cholesterol kumawonjezera mwayi wa kukhumudwa, ngozi zagalimoto ndi kufa pazifukwa zonse. Phunzirani cholesterol ya amuna ndi akazi pazaka. Chifukwa cha izi, mumvetsetsa chifukwa chomwe adokotala amawonjezera kuchuluka kwa mapiritsi a rosuvastatin kapena, motsika, amatsitsa.

Kuti muchepetse cholesterol yanu "yoyipa" komanso "yabwino" komanso triglycerides, sinthani ku chakudya chamafuta ochepa. Izi zikuthandizani kuti muchepetse kuchuluka kwa ma statins, kapena kuwasiya kwathunthu.

Atherosulinosis

Rosuvastatin, monga ma statin ena, amapatsidwa mankhwala ochizira atherosermosis. Ngati ndi kotheka kutenga atherosulinosis, ndiye kuti wodwalayo amachepetsa chiopsezo cha mtima komanso matenda obwera chifukwa cha mtima, matenda a ischemic, kufunika kwa kukantha, opaleshoni yodutsa m'mitsempha, komanso kukonza kwa magazi m'miyendo.

Moyo umakhala nthawi yayitali ndipo mkhalidwe wake umakhala bwino, makamaka ngati wodwalayo sakuda nkhawa kwambiri ndi zotsatira zoyipa. Chithandizo chachikulu cha atherosulinosis ndi kudya komanso kuchita masewera olimbitsa thupi nthawi zonse.

Mu 2006, zotsatira za kafukufuku wa ASTEROID (A Study To Evate the Effact of Rosuvastatin On Intravascular ultrasound-Derive coronary atheroma mzigo) zinafalitsidwa. Phunziroli, asayansi anali oyamba kuwonetsa kuthekera kwa ma statins kuti achepetse kukula kwa malo amtundu wa atherosrance?

Izi zidachitika pa chitsanzo cha mankhwala Krestor - woyamba mankhwala a rosuvastatin. Pambuyo pake zidakhazikitsidwa kuti chithandizo ndi atorvastatin chimaperekanso zoterezi. Atorvastatin ndi rosuvastatin ndi zolengedwa za m'badwo wa III ndi IV.

Mu 2012, zotsatira za kafukufuku wofunikira wa SUNDN (Kuwerenga kwa Coronary Atheroma ndi Intravascular Ultrasound: Mphamvu ya Rosuvastatin Versus Atorvastatin) adasindikizidwa - kuyerekezera kwa mphamvu ya rosuvastatin ndi atorvastatin kwa odwala omwe ali ndi atherosulinosis.

Phunziroli linali lozungulira, lakhungu, loyang'aniridwa ndi malo. Imachitika nthawi yomweyo m'magulu angapo azachipatala molingana ndi miyezo yolimba kwambiri. Unasankhidwa ndi odwala 1039. Theka la odwala adatenga Krestor 20-40 mg patsiku, theka lachiwiri lidatenga atorvastatin (mankhwala oyamba a Liprimar) 40-80 mg patsiku. Ophatikizira amayeserera cholesterol komanso chizindikiritso cha kutupa.

Chizindikiro	Liprimar	Crestor
Pa chiyambi	Pambuyo 2 zaka	Pa chiyambi	Pambuyo 2 zaka
Chiwerengero cha odwala	691	519	694	520
C cholesterol chonse, mg / dl	193,5	144,1	193,9	139,4
"Zoyipa" LDL cholesterol, mg / dl	119,9	70,2	120,0	62,6
"Chabwino" HDL cholesterol, mg / dl	44,7	48,6	45,3	50,4
Triglycerides, mg / dl	130	110	128	120
Apolipoprotein B, mg / dl	104,9	75,1	105,4	72,5
Apolipoprotein A1, mg / dl	126,2	137,7	128,8	146,8
C-protein yogwira, mg / l	1,5	1,0	1,7	1,1
Glycated hemoglobin HbA1C,%	6,2	6,3	6,2	6,3

Kodi mapuloteni a C-yogwira, werengani apa. Ichi ndi chizindikiro chofunikira kuposa cholesterol choyipa ndi "chabwino" pakuwunika kuopsa kwa matenda a mtima komanso sitiroko. Apolipoprotein B wanyamula "cholesterol yoyipa."

Momwe zimakhalira m'magazi, zimawonjezera chiopsezo cha atherosulinosis. Apolipoprotein A1 ndi mapuloteni omwe ali mbali ya lipensroseins yapamwamba (HDL). Sizowopsa, koma zothandiza, chifukwa zimathandiza kuchotsa cholesterol m'makoma amitsempha yamagazi. Glycated hemoglobin HbA1C ndi chizindikiro chomwe chimagwiritsidwa ntchito pozindikira matenda ashuga.

Odwala omwe adatenga nawo gawo pa kafukufuku wa SATURN adapatsidwanso ma scan a ultrasound kuti adziwe kuchuluka (TAV) ndi wachibale (PAV) voliyumu ya atherosranceotic plaque m'mitsempha yama coronary. Odwala adayang'aniridwa pafupifupi zaka ziwiri.

Krestor adatsitsa cholesterol "yoyipa" ya LDL mwa odwala kuposa atorvastatin (Liprimar). Rosuvastatin idakumananso ndi zabwino pa TAV. Ponena za PAV, zotsatira m'magulu onsewa zinali zofanana. Atorvastatin nthawi zambiri amapangitsa kuwonjezeka kwa michere ya chiwindi ndi creatinine kinase m'magazi.

Koma mwa odwala omwe adatenga rosuvastatin, mayeso omwe nthawi zambiri amawonetsa mapuloteni mu mkodzo, omwe nthawi zambiri sayenera kukhalapo. Ngakhale zonsezi, chiwopsezo chonse cha zotsatira zoyipa chinali chochepa. Mankhwala onse awiriwa atsimikizira kuthekera kwawo kuchepetsa kukula kwa zolembedwa za atherosulinotic zomwe zidapangidwa kale.

Izi sizili chete m'mabuku ambiri, koma kafukufuku wa SATURN adawonetsa kuti chithandizo cha statin chimawonjezera kuchuluka kwa calcium m'mitsempha. Mitsempha yokhala ndi calcium pamakoma awo imakhala yowuma ndikulephera kusinthasintha kwachilengedwe.

Ili ndi gawo lapamwamba la atherosulinosis. Likukhalira kuti pochiza matenda a atherosclerosis okhala ndi mapiritsi a Krestor ndi ma statin ena, sizonse zimveka. Mankhwalawa amachedwetsa kukula kwa atherosclerosis, koma kumawonjezera matendawa.

Mwa anthu omwe adamwa mankhwala enieni, cholesterol "yoyipa" ya LDL idatsika pafupifupi 50%, triglycerides - ndi 17%, mapuloteni a C-37%. Koma koposa zonse, kufupika kwa matenda amtima kwachepa kwambiri.

Chizindikiro	Rosuvastatin	Malo
Chiwerengero cha odwala	8901	8901
Myocardial infaration	31	68
Stenting, coronary bypass opaleshoni	71	131
Kugonekedwa kuchipatala chifukwa cha angina osakhazikika	16	27
Kufa kwathunthu	198	247

Analogs ndi yogwira pophika Atorvastatin

Chifukwa cha mtengo wokwera wa mankhwala oyambira a Liprimar, madokotala ambiri amapereka mankhwala omwe ali ndi mankhwala, kapena a Liprimar, kwa odwala awo.

Kuphatikizika kwa ma analogues onse kumaphatikizanso gawo la atorvastatin, koma zinthu zowonjezera zingakhale zosiyana.

Magulu a mankhwala a Liprimar ndi mankhwala opangidwa mkati ndi kumadzulo:

Generic Atoris. Mukamagwiritsa ntchito Atoris, cholesterol index imachepera kuposa 25.0%. Mankhwala a Atoris ali ndi mitundu yambiri, yomwe imapangitsa dokotala kusankha mosamala mtundu wa mankhwala. Atoris m'mbali zonse m'malo mwa Liprimar,
Analog Torvakard. Mankhwalawa amagwiritsidwa ntchito pochiza komanso kupewa matenda a mtima omwe ali ndi cholesterol yayikulu,
Analogue yaku Russia ya atorvastatin. Kwambiri m'malo a mankhwala Liprimar pa mankhwala zimapangitsa thupi.

Kuphatikiza pa atorvastatin, gawo logwira popanga simvastatin limagwiritsidwa ntchito mu lipid-kuchepetsa mankhwala.

Mankhwala ozikidwa pompopompo ndi a m'badwo woyamba wama statins ndikuwapatsa mankhwala a mtima, komanso matenda amitsempha yamagazi.

Ma Analogs a Liprimar kutengera gawo la simvastatin, pali mankhwala monga awa:

Mankhwalawa amapangidwa ku Slovenia - Vasilip,
Chithandizo cha Chidatchi Zokor,
Wopanga ku Czech ndi dzina loti Simgal.

Zotsatira zamatsenga

Kumbali yam'malingaliro am'maganizo - kuphwanya mawonekedwe a kukoma, kupezeka kwa tinnitus, ugonthi, kukha magazi kwa maso, glaucoma.

Matumbo a dongosolo:

Hemopoiesis: kuchepa kwa magazi, kuchepa kwa magazi.

Mawonekedwe osiyanasiyana amisala - kuyabwa, totupa, urticaria, dermatitis, nkhope edema, anaphylaxis.

Kuphwanya kwamanjenje - chizungulire, kugona,, tulo, amnesia, zoopsa, kukhumudwa, ataxia.

Pa mbali ya kupuma dongosolo: bronchitis, rhinitis, mphumu, mphuno, kupweteka pachifuwa.

Mavuto a mtima

Pa khungu: thukuta, seborrhea, eczema, alopecia.

Mavuto ndi genitourinary system: kwamkodzo kutakataka kapena kusungika kwamikodzo, kukakamiza pafupipafupi, cystitis, uterine kapena kutuluka kwa magazi mu ukazi, kusabala, kuchepa kwa libido, mavuto am'mimba.

Zosintha pazowonetsa zasayansi.

Cholinga chogwiritsira ntchito ma statins ndi mankhwala "Atoris"

Kukonzekera kutengera yogwira pophika rosuvastatin a m'badwo wachinayi wa ma statins.

M'badwo uno wama statins ulibe mphamvu zoyipa mthupi, chifukwa zimagwiritsidwa ntchito ngakhale mu matenda a chiwindi, komanso impso ndi kwamikodzo.

Nthawi zambiri, zotsatirazi zamankhwala zotsatira za Liprimar zimagwiritsidwa ntchito:

Analogue ku Krestor - kupanga Great Britain,
Njira zopangira Hungary - Mertenil,
Chithandizo cha Israeli Tevastor.

Mitundu yatsopano yofananira ndi choloweza mmalo a Liprimar motengera zigawo za IV (zomalizira) m'badwo (makamaka rosuvastatin) ndizosiyana pakupanga, koma zimakhala ndi zofanana. Amakhala ndi chiopsezo chochepa cha zotsatira zoyipa, choncho nthawi zina zimakhala zomveka kusankha zomwe zingachitike.

Crestor (Crestor) - mankhwala oyamba ndi rosuvastatin. Analogue yolowera ku Liprimar imadziwika ndi zotsatira zokulimbikitsa komanso kulolerana bwino, komanso pamtengo zimatuluka mtengo kwambiri kuposa ma statin ena. Mtengo uwu umapangitsa kuti asamafikire odwala ambiri.

Kudziwika kwa kapangidwe kake: kapangidwe kameneka kamagwiritsanso ntchito kosafunikira kwa anthu omwe ali ndi vuto lactase - lactose monohydrate (shuga mkaka).

Kampani yopanga: Astra Zeneca (Astra Zeneca), Great Britain.

Mtengo wapakati: kuchokera ku ma ruble 1652/28 ma PC. 5 mg iliyonse mpaka 5036 rub./28 ma PC. 40 mg aliyense.

Mtengo Wophatikiza Mtengo

Zofananira zonse ndi cholowa m'malo mwa mankhwala a Liprimar zimangoperekedwa ndi adokotala omwe amatha, mwachitsanzo, mankhwala a Torvakard, kapena Krestor, omwe ndi abwino kwa wodwalayo.

dzina lamankhwala	gawo yogwira	Mlingo wa mankhwala	mtengo muma ruble aku Russia
mankhwala Liprimar	atorvastatin thunthu	10,0 mg - 100 tabu.,	· 1720,00.
mankhwala Liprimar	atorvastatin thunthu	80.0 mg - 30 mapiritsi	· 1300,00.
Mankhwala a Atorvastatin	atorvastatin thunthu	10,0 mg - mapiritsi 30,	· 190,00.
Mankhwala a Atorvastatin	atorvastatin thunthu	40.0 mg - mapiritsi 30	· 300,00.
Mankhwala a Atoris	atorvastatin thunthu	10,0 mg - mapiritsi 30,	· 690,00.
Mankhwala a Atoris	atorvastatin thunthu	40.0 mg - mapiritsi 30	· 520,00.
mankhwala Torvakard	atorvastatin thunthu	10,0 mg - mapiritsi 30,	· 780,00.
mankhwala Torvakard	atorvastatin thunthu	40.0 mg - mapiritsi 30	· 590,00.
tulip mankhwala	atorvastatin thunthu	10,0 mg - mapiritsi 30,	· 680,00.
tulip mankhwala	atorvastatin thunthu	40.0 mg - mapiritsi 30	· 500,00.
mankhwala crestor	gawo la rosuvastatin	10,0 mg - mapiritsi 28,	· 1990,00.
mankhwala crestor	gawo la rosuvastatin	40.0 mg - mapiritsi 28	· 4400,00.
Mankhwala a Mertenil	gawo la rosuvastatin	10,0 mg - mapiritsi 30,	· 600,00.
Mankhwala a Mertenil	gawo la rosuvastatin	40.0 mg - mapiritsi 30	· 1380,00.
Kutanthauza Tevastor	gawo la rosuvastatin	10,0 mg - mapiritsi 30,	· 485,00.
Kutanthauza Tevastor	gawo la rosuvastatin	20,0 mg - mapiritsi 30	· 640,00.
mankhwala vasilip	mankhwala a simvastatin	10,0 mg - mapiritsi 28,	· 280,00.
mankhwala vasilip	mankhwala a simvastatin	40.0 mg - mapiritsi 28	· 580,00.
mankhwala Zokor	gawo la simvastatin	40.0 mg - 14 tabu.	· 460,00.

Pakuwona bwino kwa phunziroli, zoyerekeza zapafupi za Liprimar zimaphatikizidwa pamndandanda wofanizira, muyezo woyambirira komanso kuchuluka kokwanira mokwanira maphunziro ake (masabata 4), popeza ndi nthawi imeneyi yomwe mutha kudziwa kuchuluka kwa mankhwalawa.

Dzina ndi mlingo wa mankhwalawa	Chiwerengero cha mapiritsi	Mtengo pa paketi iliyonse, pakani.
Statins 3 m'badwo (atorvastatin) - 10 mg
Liprimar	30	726–784
Torvacard	30	256–312
Atorvastatin-SZ (Atorvastatin-SZ)	30	129–136
Tulip (Tulip)	30	270–343
Atoris	30	342–376
Novostat (Novostat)	30	328–374
Mitundu ya IV m'badwo (rosuvastatin) - 5 mg
Crestor	28	1739–1926
Rosuvastatin-SZ (Rosuvastatin-SZ)	30	182–212
Mertenil (Mertenil)	30	504–586

Ma fanizo opindulitsa kwambiri a Liprimar (m'mibadwo yonse) ndi mankhwala apakhomo - Atorvastatin-SZ ndi Rosuvastatin-SZ. Komabe, ziyenera kukumbukiridwa kuti ngati wodwalayo ali ndi ufulu wosankha generic payekha, ndiye kuti kuyimitsidwa kwazomwe zimagwira kuyenera kukambirana ndi adokotala.

Mankhwala ofanana

Mankhwala a Atoris ali ndi ma analogi, ndipo alipo ambiri. Mwa zina zotchuka m'malo mwa mankhwalawa ndi mapiritsi monga Atorvastatin, Liprimar, Anvistat, Torvakard, Tulip, Lipoford, Liptonorm.

Anthu ena akudzifunsa kuti ndi mankhwala ati abwinoko: Atoris kapena Liprimar? Zikuwoneka kuti njira yotsirizirayi ndi njira yoyamba, ndipo mankhwalawo adathandizidwa kuti adziwe zambiri. Ndipo, monga mukudziwa, palibe chomwe chingakhale bwino kuposa choyambachi.

Ngati tikufanizira mankhwala a Atoris, ma analogues omwe angagulidwe ku pharmacy iliyonse, ndi mankhwala a Atorvastatin, ndiye pankhani iyi mankhwala oyamba azikhala bwino. Chowonadi ndi chakuti zimapangidwa ndi kampani yayikulu yaku Europe yotchedwa Krka.

Ndipo mankhwalawa "Atorvastatin" amachitika ndi mabizinesi osiyanasiyana, kuphatikizapo osachita bwino. Chifukwa chake, ngati mungasankhe mwanjira ziwiri izi, ndibwino kuti mupitirizebe kukonda mankhwala "Atoris".

Pomaliza

Mavuto a mankhwala a Liprimar ali ndi vuto lofananalo ndi maselo a chiwindi, amachepetsa kaphatikizidwe ka mamolekyulu a cholesterol, koma musaiwale kuti kapangidwe kofananira kali ndi zinthu zina zowonjezera zomwe nthawi zambiri zimayambitsa kudwala kwa wodwala.

Chifukwa chake, kuikidwa kwa analogi kumachitika payekha malinga ndi momwe thupi la wodwalayo lilili.

Mfundo yogwira ntchito

Chifukwa cha magwiridwe antchito a receptor awa, pali kuchepa kwakukulu kwa cholesterol yochepa kwambiri.

Mankhwala oyamba amapangidwa m'mafakitale ku mayiko: USA, komanso ku Europe, Germany ndi Ireland.

Ma analogues a mankhwalawo, komanso ma jini ake, amapangidwa ndi opanga mankhwala m'mayiko ambiri padziko lapansi, komanso pali analog yaku Russia ya Liprimar.

Kufunika kopanga ma statins ndikwabwino, chifukwa chaka ndi chaka, anthu ochulukirapo padziko lapansi akuvutika ndi matenda a mtima komanso ma mtima a mtima.

Chaka chilichonse, matenda a atherosclerosis amayamba kuchepa, ndipo amuna atatha zaka 40 amapeza matendawa.

Masiku ano, kugwiritsa ntchito ma statins sikugwiritsidwa ntchito ngati mankhwala okha, komanso ngati njira yoletsa matenda a atherosulinosis.

Pharmacological zikuchokera

Mankhwala Liprimar dziko lochokera ku Germany. Gawo lothandizira ndi statin atorvastatin.

Liprimar ndi mtundu wopangira mankhwala womwe umakhudza cholesterol index ya magawo onse komanso triglycerides m'madzi a m'magazi.

Pogwiritsa ntchito kaphatikizidwe wa cholesterol ndikuchepetsa zigawo zolemera zama cell ochepa, Liprimar imakulitsa mndandanda wama lipoproteins apamwamba kwambiri, omwe amateteza magazi kutuluka kwa magazi ku mapangidwe amitsempha yamagazi, komanso thrombosis yamagulu awa ochepa.

Komanso, mankhwalawa ndi prophylactic wabwino kwambiri kuti muchepetse kukula kwa sitiroko ndi ischemia yamitsempha yamtima.

Opanga amapanga mankhwala a Liprimar mwanjira ya mapiritsi okhala ndi mawonekedwe. Kukonzekera kumakonzedwa ndi gawo la gawo la 10,5 mamiligalamu, 20.0 mg, 40.0 mg, ndi mlingo waukulu wa atorvastatin wa miligalamu 80.0 piritsi limodzi.

Piritsi lirilonse la mankhwala a Liprimar amalembedwa nambala ya Mlingo.

Komanso, momwe piritsi lililonse limaphatikizira zina:

Calcium calcium
Mg wakuba
Chomwe chimapangidwa ndi croscarmellose,
Hyp Hypellellose
Lactose Monohydrate
Dioxide ya mamolekyulu a titanium,
Talcum ufa,
Simethicone mu emulsion.

Mutha kumwa mankhwalawa nthawi iliyonse masana komanso osadwala kuti wodwalayo adya kapena ayi. Sansani mapiritsiwo kwathunthu, chifukwa amaphatikizidwa ndi zokutira zapadera zomwe zimasungunuka m'matumbo.

Piritsi limodzi ndi maola 24.

Mbale

Atorvastatin - analogue ya Liprimar - ndi amodzi mwa mankhwala odziwika kwambiri ochepetsa kupsinjika kwa lipoproteins.Kuyesedwa kochitidwa ndi Grace ndi 4S kunawonetsa kukula kwa atorvastatin kupitilira simvastatin poletsa kukula kwa ngozi ya mtima wamatenda komanso sitiroko. Pansipa timaganizira za mankhwala a gulu la statin.

Zinthu zopangidwa ndi Atorvastatin

Analogue yaku Russia ya Liprimar, Atorvastatin, imapangidwa ndi makampani opanga mankhwala: Kanofarma Production, ALSI Pharma, Vertex. Mapiritsi amlomo wokhala ndi mulingo wa 10, 20, 40 kapena 80 mg. Tengani kamodzi patsiku pafupifupi nthawi yomweyo, osadya.

Nthawi zambiri makasitomala amadzifunsa - Atorvastatin kapena Liprimar - ndibwino?

Machitidwe a pharmacological a Atorvastatin ali ofanana ndi machitidwe a Liprimar, chifukwa mankhwalawo pamaziko ali ndi chinthu chimodzi chogwira ntchito. Limagwirira ntchito cha woyamba mankhwala umalimbana kusokoneza kapangidwe kolesterol ndi atherogenic lipoproteins ndi maselo a thupi. M'maselo a chiwindi, kugwiritsidwa ntchito kwa LDL kumawonjezeka, ndipo kuchuluka kwa kupanga ma anti-atherogenic high-density lipoproteins kumakulanso pang'ono.

Atorvastatin asanaikidwe, wodwalayo amasinthidwa kukhala chakudya ndikumupatsa njira yochitira masewera olimbitsa thupi, zimachitika kuti izi zimabweretsa kale zotsatira zabwino, ndiye kuti mankhwala a statins amakhala osafunikira.

Ngati sizotheka kusintha mtundu wa cholesterol osakhala mankhwala, mankhwala a gulu lalikulu la statins ndi omwe amaperekedwa, omwe akuphatikizapo Atorvastatin.

Pa gawo loyamba la mankhwalawa, Atorvastatin amayikidwa 10 mg kamodzi patsiku. Pambuyo pa masabata 3-4, ngati mulingo wosankhidwa mosiyanasiyana, kusintha kwa mawonekedwe a lipid kumaonekera. Mu mbiri ya lipid, kuchepa kwa cholesterol yathunthu kumadziwika, kuchuluka kwa lipoproteins yotsika komanso yotsika kwambiri kumachepa, kuchuluka kwa triglycerides kumachepa.

Ngati mulingo wa zinthu izi sunasinthe kapena ngakhale kuchuluka, ndikofunikira kusintha mlingo wa Atorvastatin. Popeza mankhwalawa amapezeka pamiyeso ingapo, ndikofunikira kwa odwala kuti asinthe. Patatha milungu 4 mutachulukitsa mlingo, kusanthula kwa lipid kumachitika mobwerezabwereza, ngati kuli kotheka, mlingo umakulanso, mlingo waukulu tsiku lililonse ndi 80 mg.

Makina ochitira, Mlingo ndi zoyipa za Liprimar ndi mnzake waku Russia ndizofanana. Ubwino wa Atorvastatin umaphatikizapo mtengo wake wotsika mtengo. Malinga ndi ndemanga, mankhwala a ku Russia nthawi zambiri amayambitsa zovuta komanso chifuwa poyerekeza ndi Liprimar. Chosangalatsa china ndi chithandizo cha nthawi yayitali.

Zina m'malo mwa Liprimar

Atoris - analogue of Liprimar – mankhwala opangidwa ndi kampani yopanga mankhwala ku Slovenia KRKA. Ndiwonso mankhwala ofanana mu mankhwala ake a Liprimaru. Atoris imapezeka ndi mulingo wambiri poyerekeza Liprimar. Izi zimathandizira adokotala kuti athe kuwerengera mosamala mankhwalawo, ndipo wodwala amatha kumwa mankhwalawo mosavuta.

Atoris ndi mankhwala okhawo a generic (Liprimara generic) omwe adakumana ndi mayesero ambiri azachipatala ndipo adawatsimikizira kuti amagwira ntchito bwino. Odzipereka ochokera kumayiko ambiri anachita nawo kafukufukuyu. Kafukufukuyu adachitika pamaziko a zipatala ndi zipatala. Zotsatira zamaphunziro mu maphunziro 7000 omwe atenga Atoris 10 mg kwa miyezi iwiri, kuchepa kwa atherogenic ndi cholesterol yathunthu ndi 20-25% idadziwika. Kupezeka kwa zoyipa ku Atoris ndizochepa.

Liptonorm ndi mankhwala a ku Russia omwe amateteza kagayidwe ka mafuta m'thupi. Zomwe zimagwira ntchito yake ndi atorvastine, chinthu chomwe chili ndi hypolipidemic ndi hypocholesterolemic kanthu. Liptonorm imakhala ndi zofanana pakugwiritsa ntchito komanso kumwa ndi Liprimar, komanso zovuta zina.

Mankhwalawa amapezeka mu mitundu iwiri yokha ya 10 ndi 20 mg.Izi zimapangitsa kuti ikhale yovuta kugwiritsidwa ntchito ndi odwala omwe ali ndi vuto lochiritsika la atherosulinosis, heterozygous Famer hypercholesterolemia, ayenera kumwa mapiritsi a 4-8 patsiku, popeza tsiku lililonse ndi 80 mg.

Torvacard ndiye analogue wodziwika kwambiri wa Liprimar. Kupanga kampani ya mankhwala ku Slovak Zentiva. "Torvacard" yakhazikitsa bwino kukonzanso kwa cholesterol kwa odwala omwe ali ndi matenda a mtima. Imagwiritsidwa ntchito bwino pochiza odwala omwe ali ndi vuto la kuchepa kwa magazi m'thupi komanso kuchepa kwa mtima, komanso kupewa zovuta monga kugwidwa ndi matenda a mtima. Mankhwala amathandizira kuchepetsa kuchuluka kwa triglycerides m'mwazi. Imagwiritsidwa ntchito bwino pochiza matenda amtundu wa dyslipidemia, mwachitsanzo, kuonjezera milingo ya "othandiza" yapamwamba kwambiri ya lipoprotein.

Mitundu yotulutsidwa kwa "Torvokard" 10, 20 ndi 40 mg. Mankhwala a atherosulinosis amayamba, nthawi zambiri amakhala ndi 10 mg, atatha kukhazikika pamlingo wa triglycerides, cholesterol, lipoproteins wotsika. Pambuyo 2-4 milungu kuchita kusanthula kuwonekera kwa lipid sipekitiramu. Ndi chithandizo cha mankhwala, onjezani mlingo. Mlingo waukulu patsiku ndi 80 mg.

Mosiyana ndi Liprimar, Torvacard imathandiza kwambiri odwala omwe ali ndi matenda a mtima.

Zinthu zopangidwa ndi Rosuvastatin

"Rosuvastatin" ndi wothandizira m'badwo wachitatu womwe umapangitsa kuchepa kwa lipid. Kukonzekera komwe kumapangidwa pamaziko ake kumatha kusungunuka bwino m'magazi amadzi. Cholinga chawo chachikulu ndikuchepetsa kolesterol yathunthu ndi lipoprotein atherogenic. Mfundo ina yabwino, "Rosuvastatin" ilibe vuto lililonse m'maselo a chiwindi ndipo siziwononga minofu ya minofu. Chifukwa chake, ma statins omwe amachokera ku rosuvastatin sakonda kuyambitsa zovuta mu chiwindi, kulephera kwa transaminase, myositis, ndi myalgia.

Chachikulu pharmacological kanthu umalimbana kuphatikiza kaphatikizidwe ndikuwonjezera kuchulukana kwa zigawo za mafuta a atherogenic. Zotsatira zamankhwala zimachitika mwachangu kwambiri kuposa chithandizo cha Atorvastatin, zotsatira zoyambirira zimapezeka kumapeto kwa sabata loyamba, mphamvu yayitali imatha kuonedwa pakadutsa masabata atatu.

Mankhwala otsatirawa amachokera ku rosuvastatin:

"Crestor" kapena "Liprimar" choti musankhe? Kukonzekera kuyenera kusankhidwa ndi adokotala.

Zogwiritsa ntchito Simvastatin

Chithandizo china chodziwika chotsitsa lipid ndi Simvastatin. Kutengera ndi ichi, mankhwala angapo apangidwa omwe amagwiritsidwa ntchito bwino pochiza matenda a atherosulinosis. Kuyesedwa kwachipatala kwa mankhwalawa, komwe kwachitika zaka zoposa zisanu ndikuphatikizira anthu opitilira 20,000, kwathandizira kunena kuti mankhwala opangidwa ndi simvastatin amachepetsa chiopsezo cha kugunda kwamtima ndi stroke chifukwa cha odwala omwe ali ndi matenda amtima komanso a cerebrovascular pathologies.

Analogs of Liprimar on simvastatin:

Chimodzi mwazinthu zodziwitsa zomwe zimakhudza kugulidwa kwa mankhwala enaake ndi mtengo wake. Izi zimagwiranso ntchito kwa mankhwala omwe amabwezeretsa zovuta zama metabolism yamafuta. Chithandizo cha matenda ngati amenewa chimapangidwa kwa miyezi yambiri, ndipo nthawi zina zaka. Mitengo yamankhwala ofanana mu zamankhwala amasiyana pamakampani opanga mankhwala nthawi zina chifukwa cha mitengo yamitengo yosiyanasiyana yamakampani awa. Poika mankhwala ndi kusankha kwa mankhwalawa kuyenera kuchitika ndi adotolo, komabe, wodwalayo ali ndi kusankha kwa mankhwala kuchokera ku gulu limodzi lama pharmacological, lomwe limasiyana mu wopanga ndi mtengo.

Mankhwala onse omwe ali pamwambapa komanso akunja, omwe amalowa m'malo mwa Liprimar, adutsa mayeso azachipatala ndipo adziyambitsa okha ngati othandizira omwe amachepetsa mafuta. Zabwino mwa njira yochepetsera cholesterol zimawonedwa mu 89% ya odwala mwezi woyamba wa chithandizo.

Ndemanga za Liprimar ndizabwino.Mankhwala amachepetsa mafuta m'thupi, amachepetsa chiopsezo cha matenda a mtima. Mwa zinthu zoyipa - mtengo wokwera ndi zoyipa. Za fanizo ndi ma jenito, ambiri monga Atoris. Zimagwira chimodzimodzi kwa Liprimar, kwenikweni sizimayambitsa mayendedwe olakwika a thupi.

Ndemanga zimatsimikizira kuti pakati pazofananira zotsika mtengo, Russian Liptonorm ndiyomwe imakonda. Zowona, machitidwe ake ndi oyipa kuposa a Liprimar.

Ziwerengero zamankhwala zikuwonetsa kuti mavuto amtima akutsogolera mndandanda wazomwe zimayambitsa kufa ku Russia komanso padziko lonse lapansi. Kukhala ndi chidwi ndi thanzi lanu kumaphatikizapo njira yochizira ndi mankhwala ogwira, omwe amadziwika kuti Liprimar. Imatsitsa cholesterol, kukhala ndi phindu pa ntchito ya mtima. Mankhwala amachepetsa chiopsezo cha ischemia ndi kukula kwa zovuta, kukulitsa moyo wa wodwala nthawi zambiri.

Malangizo ogwiritsira ntchito Liprimara

Liprimar amalembedwa ndi adokotala omwe ali ndi mitundu yosiyanasiyana komanso machitidwe osiyanasiyana, zomwe zimatengera wodwalayo. Pamodzi ndi kufunsa dokotala, ndikofunikira kuwerenga malangizo ogwiritsira ntchito mankhwalawa. Ili ndi chidziwitso chofunikira chokhudza contraindication ndi zovuta, kugwiritsidwa ntchito kwa mankhwala osokoneza bongo. Kuzindikira nkhaniyi kumapangitsa kuti chithandizo cha mankhwala chikhale chothandiza.

Pharmacodynamics ndi pharmacokinetics

Zomwe zimagwiritsidwa ntchito ndi mankhwala atorvastatin ndi choletsa kusankha kwa enzyme yomwe imasintha mevalonate (moyambirira kwa ma steroid). Atorvastatin amachepetsa kuchuluka kwa plasma lipoproteins otsika, apolipoprotein B, triglycerides (TG), ndipo amathandizira kuwonjezeka kosasunthika kwakukulu kwa lipoproteins ngati hyperlipidemia kapena hypertriglyceridemia ipezeka.

Mankhwala mwachangu odzipereka pambuyo makonzedwe. Kuzindikira kwakukulu kumatheka pambuyo pa ola limodzi ndi theka mpaka maola awiri. The bioavailability wa yogwira mankhwala mapiritsi ali pa 95-99%. Kuphatikiza kwake mapuloteni a plasma ndi 98%. Kuchoka kwa mankhwalawa kumachitika ndi bile pambuyo pakuwonjezera kwa metabolite kapena hepatic pafupifupi maola 28.

Zizindikiro zogwiritsidwa ntchito

Ngati wodwala ali ndi hypercholesterolemia (cholesterol yokwezeka) kapena hypertriglyceridemia, mankhwalawa amagwiritsidwa ntchito monga chakudya kuwonjezera mankhwala ochepetsa triglycerides, ngati njira zina zosagwiritsa ntchito mankhwala sizinabweretse zotsatira zomwe mukufuna. Maphunzirowa adapatsidwa:

Kuchepetsa kuchuluka kwa lipoproteins mwa odwala a homozygous Famer hypercholesterolemia, dysbetalipoproteinemia, dyslipidemia (kuphwanya chiŵerengero cha lipids m'magazi seramu),
kupewa matenda a mtima ndi kupewera kwachiwiri kwa odwala ischemia (stroke, vuto la mtima, angina pectoris).

Mlingo ndi makonzedwe

Asanayambe chithandizo ndi Liprimar, wodwalayo ayenera kuyesa kuchepetsa magazi m'thupi chifukwa cha zakudya, masewera olimbitsa thupi komanso kuwonda. Mapiritsi amatengedwa mosasamala chakudya. Mlingo wa 10-80 mg / tsiku umayikidwa kutengera milingo yoyambira ya osachulukitsa lipoproteins:

Njira ya mankhwala, milungu

Hypercholesterolemia, hyperlipidemia yosakanikirana

Homozygous achibale hypercholesterolemia kapena hypertriglyceridemia

Malangizo apadera

Mankhwala Liprimar amatanthauza lipid-kuchepetsa mankhwala, motero, pakayendetsedwe kake, ma seramu a michere ya chiwindi amatha kuchuluka. Malangizo ena apadera:

Asanatenge, atatha masabata 6 ndi 12 atatha kudya kapena kuwonjezera mlingo, odwala ayenera kuwunika zizindikiro za chiwindi.
Chiwopsezo chokhala ndi myopathy chimawonjezeka ndi kuphatikiza kwa mankhwalawa ndi cyclosporine, fibrate, nicotinic acid, Erythromycin, othandizira antifungal.
Potengera momwe mankhwalawa amathandizira, mankhwala a rhabdomyolysis (chiwonongeko cha minofu) amatha kuchitika, limodzi ndi myoglobinuria (mawonekedwe a mapuloteni mumkodzo).

Kuyanjana kwa mankhwala

Atorvastatin imapangidwa ndi cytochrome isoenzyme, chifukwa chake, kuphatikiza ndi zoletsa zake kumabweretsa kuwonjezeka kwa ndende ya plasma. Kuphatikiza kwa mankhwala kumabweretsa mavuto:

Cyclosporin imawonjezera bioavailability wa yogwira pophika, Erythromycin, Clarithromycin, Diltiazem, Itraconazole ndi proteinase inhibitors amawonjezera ndende yake m'magazi.
Efavirenz, Rifampicin, maantacid okhala ndi magnesium kapena aluminium hydroxide, Colestipol amachepetsa gawo la gawo lomwe limagwira.
Kuphatikiza ndi digoxin kumafuna kusamala chifukwa kuperewera kwa magazi.
Mankhwalawa amathandizira kuchuluka kwa norethisterone ndi ethinyl estradiol akaphatikizidwa ndi njira zakulera zamlomo.

Bongo

Zizindikiro zakuchuluka kwa mapiritsi a Liprimar ndizochulukitsa zoyipa, zowonetsedwa ndi pafupipafupi. Palibe mankhwala enieni othetsa mankhwalawa. Ndikofunikira kusiya zizindikiritso za kuchuluka kwa mlingo pochita mankhwala. Hemodialysis yochotsa zinthu zochulukirapo sizothandiza.

Migwirizano yogulitsa ndikusunga

Mapiritsi othandizira. Mankhwalawa amatha kusungidwa kutentha mpaka madigiri 25 kwa zaka zitatu.

M'mafakitala, pamakhala malo ena omwe mankhwalawo ali ndi mphamvu yofananira ndipo nthawi zina chinthu chomwecho. Analogs of Liprimar:

Atoris - atorvastatin wokhala ndi lipid-wotsitsa, wopangidwa ndi fakitale ya ku Slovenia,
Liptonorm - choletsa choyambirira cha cholesterol synthesis, chomwe chili ndi atorvastatin,
Torvacard - mapiritsi opangidwa ku Czech ochiza matenda a hyperlipidemia,
Atorvox - mankhwala oletsa hypercholesterolemia,
Tribestan - mapiritsi zochizira kusabala, ndi lipid-kutsitsa mphamvu kwa odwala dyslipoproteinemia.

Liprimar kapena Crestor - ndibwinoko

Malinga ndi akatswiri, chithandizo cha atherosulinosis chiyenera kuchitika ndi mankhwala oyamba omwe amakhala ndi ma statins ndi kutsimikizika kogwira ntchito. Mankhwala onse omwe amawunikira ali ndi vuto lofanana, zinthu zofananira (atovrastatin ndi rosuvastatin), zomwe zimathandiza kuti kusinthanitsana pochiza matenda. Ndi iti yomwe ili yabwino kwa wodwala, ndi dokotala yekha yemwe amadziwa.

Liprimar kapena Atorvastatin - ndibwino

Poyerekeza ndi mankhwala oyamba, Atorvastatin ndi generic (kopi). Ndiwofanana mu kapangidwe kake ndikuyang'anitsitsa zinthu zomwe zimagwira, koma mtundu wa zopangira ndizosiyana. Generic ndi yotsika mtengo, koma ili ndi zovuta zina komanso contraindication. Ndikwabwino kupatsa chidwi ndi mankhwala oyambawo, makamaka ngati vuto la wodwalayo ndilovuta kapena zovuta.

Zambiri pazamankhwala ndi malangizo ogwiritsira ntchito

Maziko a "Crestor" ndi yogwira ntchito rosuvastatin. Ndi m'badwo wachinayi wa ma statins, omwe ndi omwe amamwa mankhwala othandiza kwambiri a cholesterol omwe ali ndi mavuto ochepa. Zinthu izi zimakhala ndi njira ziwiri zopangira. Mwa kapangidwe kake ka mankhwala, amalepheretsa enzyme yomwe imayambitsa kusintha kwa mafuta azakudya kuti akhale cholesterol m'chiwindi.

Pafupifupi 80% ya cholesterol imapangidwa mu hepatocytes (ndi chiwindi), ndi 20% yokha yomwe imalowa m'matumbo otaya mu mawonekedwe omalizidwa (ndi nyama yamafuta, yolk ndi zakudya yokazinga). Ma Statins amatseka njirayi, potero, amachepetsa kuchuluka kwa mafuta m'thupi m'magazi.

Mbadwo wachinayi wa mankhwala uli ndi ntchito zowonjezereka motsutsana ndi LDL (iyi ndi imodzi mwazigawo za cholesterol yomwe imapanga atherosulinotic plaques). Mankhwala amathandiza kuwachotsa m'magazi kudzera mu njira yowonjezera. "Krestor" ndi mankhwala othandiza kwambiri, okhala ndi mlingo woyenera, amachepetsa cholesterol kukhala chizolowezi chazamoyo mkati mwa mwezi.

Kukonzekera kwa Rosuvastatin zotchulidwa motere:

cholesterol yayikulu
matenda a mtima ndi mtima,
kuchira pambuyo opaleshoni,
atherosulinosis.

Mankhwalawa amapezeka m'mapiritsi otsekemera. Kuphimba kumakupatsani mwayi kuti mupulumutse mankhwalawa ku zotsatira za madzi am'mimba ndikuperekera chiwindi mu mawonekedwe osasinthika, ogwirira ntchito. Mapiritsi opezeka m'mafakisoni amatha kupezeka mu Mlingo wa 5, 10 ndi 20 mg. Phukusi limodzi la "Crestor" pakhoza kukhala zidutswa 30, 60 ndi 90.

Mankhwala amagwiritsidwa ntchito muyezo 1 mankhwala patsiku. Ndikofunika kuti muzimwera madzulo, ola limodzi mutadya, kumwa madzi ambiri.

Kutalika kwa maphunzirowa kumatsimikiziridwa ndi adokotala okha. Pafupifupi, ndi miyezi 2-6. Woopsa milandu ya atherosulinosis, mankhwala ndi mankhwala. Malinga ndi kafukufuku wazachipatala, anthu omwe ali ndi vuto la atherosulinosis ndipo akutenga rosuvastatin amakhala zaka pafupifupi 10 kuposa odwala omwe akukana mankhwalawo.

Ma analogi odziwika kwambiri ndi choloweza mmalo mwa "Crestor"

Msika wamakono wamankhwala umapatsa ogula mankhwala osiyanasiyana - fanizo la chinthu chomwe chikugwira. Rosuvastatin imapezekanso m'magulu opanga osiyanasiyana. Ganizirani mafanizo apamwamba kwambiri komanso othandiza komanso mayendedwe a Krestor, mawonekedwe awo, mtengo wake ndi momwe angagwiritsidwire ntchito.

Omwe alowa m'malo mwa Slovenia "Crestor" kampani "Krka". Zimapangidwa mu Mlingo wa mapiritsi 10, 20 mg a 30, 60 ndi 90 pa paketi iliyonse. Mitengo yotsika mtengo (kuyambira 379 ma ruble) ndi mtundu wapamwamba kwambiri imapangitsa mankhwalawa kukhala amodzi ofanana ndi "Crestor".

Mankhwalawa amaletsedwa kuti agwiritsidwe ntchito ndi odwala omwe ali ndi matenda oopsa a chiwindi. Asanaikidwe ndi Roxers, katswiri wodziwa bwino amayenera kusankha kuyesa kwa magazi a biochemical, komwe kumawunikira osati kuchuluka kwa cholesterol ya plasma, komanso zisonyezo monga AST ndi ALT. Kupatuka kwawo kumawonetsa kukhalapo kwa matenda a chiwindi. Malinga ndi kusanthula kwa zamankhwala amuzolengedwa, njira za impso zimatha kupezekanso, zomwe zimaphatikizanso zotsutsana ndi mankhwalawa.

Mlingo ndi kayendetsedwe ka kayendedwe kamafanana - piritsi 1 yamadzulo atatha kudya chakudya chamadzulo.

ChiHungary generic, yemwenso ndi m'badwo wachinayi wa ma statins. Amapangidwa ndi kampani ya Gideon Richter. Wopanga uyu wakhala alipo pamsika wamankhwala kwazaka zambiri ndipo adadzikhazikitsa ngati wodalirika komanso wodzipereka. Zosakaniza zogwira zimatsukidwa ndikukonzedwa, zomwe zimachepetsa kwambiri zotsatira zoyipa. Mankhwalawa amapezeka mu Mlingo wa mapiritsi 5, 10, 20 mg mu 30, 60 ndi 90 piritsi lililonse. Mtengo wongoyerekeza m'mafakitale kuchokera ma ruble 488.

Mosamala kwambiri, kugwiritsa ntchito analogi kuyenera kuganiziridwanso kwa okalamba. Kwa anthu opitilira 70, mlingo wosaposa 5 mg ndi osavomerezeka. Chosiyana ndi zomwe dokotala amakupatsani mukamaliza mayeso onse ofunikira.

Analogue yaku Czech yaku kampani ya Zentiva. Amapangidwa mu Mlingo wa 5, 10, 20 ndi 40 mg, mapiritsi 30 pa bokosi lililonse. Mtengo wokwera kwambiri wa mankhwalawa (kuchokera pa ma ruble 602) ndi chifukwa cha kuyera kwapangidwe komanso kuchuluka kwa kuyeretsa komwe kumagwira ntchito. Ichi ndi mankhwala apamwamba komanso othandiza omwe, akagwiritsidwa ntchito mwadongosolo, amapereka zotsatira zabwino ndikuchepetsa kwambiri mafuta m'thupi.

"Rosucard" imagwira ntchito pothana ndi cholowa chamafuta a metabolism yamafuta. Ichi ndi chimodzi mwazinthu zomwe zimasankhidwa ka Crestor. Amalembedwa kwa anthu omwe ali ndi matenda a hypercholesterolemia ya mabanja, amakhazikika ndi mafuta m'thupi. Contraindicated mu anthu omwe ali ndi impso komanso chiwindi matenda. Kuyesedwa koyambirira kwa magazi kuchokera mu mtsempha wa biochemistry kumafunika pakuwunika kwa AST ndi ALT.

Kampani ya mankhwala aku Hungary a Egis Pharmaceutical.Ndiwophatikiza wapadera wa rosuvastatin ndi acetylsalicylic acid. Vuto lalikulu ndi atherosulinosis limalepheretsa kuyenda kwa magazi, kusakwanira kwa okosijeni ndi michere ya minofu ndi ziwalo.

Rosuvastatin amathandizira kusungunula ma atherosselotic malo, ndipo acetylsalicylic acid amachepetsa magazi m'miyeso yaying'ono. Kuchita kawiri konseku kumakuthandizani kuti muchepetse kuthana ndi vuto la mtima komanso sitiroko komanso kuchepetsa milomo ya magazi.

Mtengo wa "Rosulip" m'masitolo aku Russia ndi kuchokera ku ma ruble a 459. Mankhwalawa amagwiritsidwa ntchito 1 nthawi patsiku.

Mnzake waku Israeli waku Teva. Zimakhazikitsidwa pazomwe zimagwira - rosuvastatin. Mankhwalawa ndi mibadwo 4 ya ma statins. Kugwiritsa ntchito kwambiri kwa Tevastor pokhudzana ndi matenda amtima kumadziwika. Anthu omwe amamwa mankhwalawa ali ndi mwayi wochepa wokhala ndi myocardial infarction ndi matenda a ziwalo.

Pa msika wogulitsa mankhwala ku Russia, Tevastor ikhoza kugulidwa pamtengo wa 280 rubles. Mtengo umasiyanasiyana malingana ndi kuchuluka kwa mankhwala othandizira komanso kuchuluka kwa mapiritsi okhala phukusili. Mankhwalawa amatengedwa ngati mupetsedwa ndi dokotala kamodzi pa tsiku mutatha kudya kwa nthawi yayitali.

Kodi mankhwala othandizira kuthamanga kwa magazi amatha kupititsa patsogolo moyo waoposa ma centenarian ndikuwalola kuti azikhala zaka zoposa 122 (lero zaka 122 ndi mbiri)?

Mankhwala a gulu la Sartans ndi ACE zoletsa amaonjezera moyo ndipo amateteza kukalamba msanga chifukwa chotetezedwa ku zotsatira zoyipa za kuthamanga kwa magazi ndi ukalamba komanso kukula kwa matenda a shuga a mtundu wachiwiri. Ngati anthu amakonda kudwala matenda a shuga ndi matenda amtima, ndiye kuti zikuwonekeratu kuti chifukwa chiyani ma sartan ndi ACE inhibitors atha kukhala othandiza kwambiri kwa ife. Ndipo kodi mankhwalawa athandizira kukulitsa moyo waomwe akhala akuchita zamanthawi yayitali (omwe amakhala popanda mankhwala zaka 110-120)? Kupatula apo, kwa nthawi yayitali alibe mavuto kapena alibe magazi ndi kuthamanga kwa magazi ndi insulin. Kuti muchite izi, muyenera kuwona momwe mankhwalawa amagwirira ntchito pazitsanzo za mbewa zokhala ndi moyo wautali - chitsanzo cha "abodza akulu okalamba." Kuti tichite izi, timaganizira kafukufuku momwe mankhwala abwino kwambiri a gulu la ACE inhibitor (ramipril) anapatsidwa kwa mbewa zamphongo za B6C3F1 zazitali. Phunziroli, ramipril pafupifupi sanatalikitse moyo wa mbewa. Komanso mmodzi wa sartani (candesartan) sanatalikitse moyo, ndipo statin (fluvastatitis) sanatalikitse nthawi.

Koma kuphatikiza kwa simvastatin ndi ramipril kunakulitsa chiyembekezo cha moyo wapakatikati ndi 9%. Koma zochulukira sizinachulukenso. Ndiponso, mathero akufa? Momwe mungakulitsire moyo wa opitilira apaulendo pazaka 122?

Lumikizani izi:

Tiyeni tisanthule phunziroli mosamala, koma izi zisanachitike, kumbukirani izi

M'mayiko otukuka, kufera kwa matenda amtima wamkati mwa anthu opitilira 85 kunayamba kuchepa atangoyambanso kupezeka kwa ma statin - nthawi ina itatha 1997. Likukhalira kuti kuphatikiza kwa mankhwalawa kwa kuthamanga kwa magazi ndi ma statins ndi malo odalitsika kwambiri. Inde, mwachitsanzo, zawonetsedwa mwa anthu kuti kuphatikiza kwa mankhwala a ACE inhibitor omwe ali ndi ma statins kumachepetsa kufa (kuposa uliwonse wa mankhwalawa mosiyana) mwa odwala omwe ali ndi matenda osokoneza bongo omwe ali ndi miyendo yonyansa yam'mbuyo.

Lumikizani phunziroli:

Ganizilaninso za phunziroli ndi mbewa zokhala ndi moyo wautali, zomwe tidaphunzira pamwambapa.

Phunziroli, simvastatin (mankhwala ochokera ku gulu la ma statins) adayamba kutalikitsa moyo (onani graph), kenako modzidzimutsa pakati pa moyo wa mbewa, zotsatira za statin zidazimiririka - samalani ndi mawonekedwe a kink pamagalasi! Chifukwa chiyani? Kumbukirani kuti awa ndi mbewa zokhalitsa za mzere wa B6C3F1. Pazomwe zimachitika pakufa ndi matenda a mbewa izi, olemba kafukufuku adawonetsa kuti kuphatikiza kwa simvastatin + ramipril kunachepetsa chidwi cha insulin. Mwanjira ina, kuphatikiza pambuyo pa msinkhu wina kunayambitsa mtundu wachiwiri wa matenda a shuga.Ndipo, poyamba, mbewa zinkakula pang'onopang'ono, koma kenako, chifukwa cha mtundu wachiwiri wa matenda ashuga, zinayambanso kukalamba mwachangu. Ndiye chifukwa chake moyo wawo wapakatikati wakula ndi 9%, koma kutalika sikunasinthe. Ndiye kuti, mbewa yomaliza kuchokera ku gulu lomwe limagwiritsa ntchito ramipril moyo wake wonse ndi simvastatin idamwalira nthawi yomweyo momwe mbewa yomaliza kuchokera ku gulu la mbewa zomwe sizinagwiritse ntchito chilichonse zinafa.

Mwa njira, vuto la shuga ndilabwinobwino kwa ma statins. Kupatula apo, kafukufuku akuwonetsa kuti ma statins amawonjezera chiopsezo cha matenda a shuga a 2 ndikuchepetsa mphamvu ya insulin ndikugwiritsa ntchito nthawi yayitali kwa miyezi ndi zaka.

Lumikizani phunziroli:

Koma zimachitika pokhapokha ngati nthawi yayitali mankhwala opatsirana akuchepetsa. Koma bwanji ngati ma statins ndi sartan sagwiritsidwa ntchito mosalekeza, koma m'malo achidule mu mini mini. Inde, ngati muwagwiritsa ntchito mufupifupi maphunziro, ndiye kuti mavuto alibe nthawi yopangira - makamaka mu Mlingo wa mini.

Chifukwa chiyani mini-Mlingo? Ndipo chifukwa minidoses imakhala yopindulitsa kwambiri kwa mtima ndi mitsempha yamagazi kuposa yayikulu. Chifukwa chake amodzi mwa ma statins (rosuvastatin) amakhala ndi zotsatira zabwino pokhapokha pamlingo wocheperako, koma osati pamitundu yayitali. Mlingo wocheperako, rosuvastatin kwambiri imachulukitsa kachulukidwe ka capillaries ndikuwonjezera kuthamanga kwa magazi. Zambiri, ngakhale zimachepetsa cholesterol bwino, zopindulitsa nazo ndizochepa.

Lumikizani phunziroli:

Rosuvastatin-SZ

Medicical ya Russian kupanga kampani ya Severnaya Zvezda. Ichi ndi chiwonetsero chotsika mtengo cha "Crestor" poyerekeza ndi mindandanda yonse. M'malo ogulitsa mankhwala ku Russia, zitha kugulidwa pamtengo wa 162 rubles.

Ubwino wa kampaniyi ndimtundu waukulu komanso kuchuluka kwa mapiritsi omwe ali phukusi. Mankhwalawa amapezeka mu 5, 10, 20 ndi 40 mg mu 30, 60, mapiritsi 90 pa bokosi lililonse. Mtengo wotsika mtengo sukuchotsa mu mtundu wa mankhwala omwewo. Ndiwothandizanso ngati anzako okwera mtengo.

Mosamala kwambiri, okalamba omwe ali ndi zaka zopitilira 70 ayenera kutenga Rosuvastatin-SZ. Mlingo woposa 5 mg umaloledwa kokha ndi mankhwala omwe dokotala amakupatsani.

Kampani yopanga mankhwala ku Slovenia Sandoz. Amapezeka mu Mlingo wa mapiritsi a 5, 10 ndi 20 mg a 30, 60 ndi 90 pa paketi iliyonse. Ndikulimbikitsidwa kuti muyambe kugwiritsa ntchito mlingo wa 5 mg. Pakatha mwezi umodzi wa chithandizo, mphamvu yake imadzadziwonetsa, ndipo ngati sikokwanira, ndiye kuti pokhapokha mlingo ukhoza kuchuluka. Mwa mitundu yayikulu ya atherosulinosis, adokotala amatha kuyambitsa "Suvardio" pa 10 kapena 20 mg. Palibe choletsedwa kuchita izi paokha, chifukwa mankhwalawo ali ndi zotsutsana zake.

Musanagwiritse ntchito mankhwalawa, ndikofunikira kuyesa kuchuluka kwa transmase yophika: AST ndi ALT, komanso zolembera zam'maso za impso. Suvardio yekha amaloledwa ndi impso komanso chiwindi chokwanira.

Maganizo abwino a anthu

Mwambiri, kuwunika kwa Atoris kumamveka ndi kuvomerezedwa. Odwala ambiri atagwiritsa ntchito mankhwalawa, cholesterol imasintha, ndipo, zosamveka bwino, zovuta zoyambazi sizipezeka mwa aliyense.

Komanso, odwala amadziwa kuti pamankhwala onse otere, mapiritsi a Atoris ndiwomwe amawerengera kwambiri mankhwalawa omwe ali m'gulu la ma statins. Koma izi sizitanthauza kuti mapiritsiwo ndi otsika mtengo. Izi ndizachidziwikire, ndizodula, koma tikayerekeza ndi mankhwala ena, mapiritsi a Atoris, ndemanga zake zomwe zimatha kuwerengedwa pamaforamu osiyanasiyana, ndiotsika mtengo kuposa enawo.

Ngakhale pali ndemanga zokwanira zingapo za mankhwalawa, odwala omwe adazindikira kuti Mulimonsemo, chithandizo chiyenera kuyikidwa ndi adokotala okha ndipo ayenera kuyang'aniridwa.

Krestor kapena Liprimar: ndibwino bwanji?

Liprimar ndi mankhwala ochokera ku gulu la statins a m'badwo wachitatu.Ali ndi hypocholesterolemic yotchulidwa, koma poyerekeza ndi mankhwala a mibadwo 4 ali ndi zovuta zingapo.

Ngati ndi kotheka, ikani chidwi ndi "Crestor", chifukwa ndi chabwino komanso motetezeka m'malo ake.

Komwe mungagule fanizo la "Crestor"?

Muthagula ma analogi a Krestor m'mafakitaneti pa intaneti osachoka kwanu.

Ma makekeresi apamwamba komanso otsimikiziridwa ambiri:

1. https://apteka.ru. Mitengo ya mankhwalawa ndi pafupifupi ofanana ndi mitengo yamsika yomwe ikuwonetsedwa patebulopo. Mankhwala amaperekedwa m'masiku ochepa ku pharmacy yapafupi.
2. https://wer.ru. Poyerekeza, lingalirani mitengo. "Crestor" mapiritsi 10 mg 28 - 1618 ma ruble. "Rosuvastatin - SZ" mu mlingo womwewo - 344 ma ruble.

Mankhwala angagulidwe ku pharmacy wamba wamba. Nawa ma adilesi a masitolo ogulitsa mankhwala aku Moscow, momwe ma analogu amenewa amapezeka nthawi zonse pamitengo yotsika:

1. "Rigla." St. Nagatinskaya, 31. Foni: 8-800-777-0303.
2. "Mankhwala". St. Masterkova, 3. Foni: +7 (495) 730-5300.

Mafunso Ofunsidwa Kawirikawiri

Otsatirawa ndi mayankho a mafunso omwe nthawi zambiri amakhala Odwala.

Kodi Crestor amatenga nthawi yayitali bwanji?

Monga mapiritsi ena a cholesterol yayikulu, Krestor iyenera kumwa tsiku lililonse moyo wanu wonse ngati muli ndi chiopsezo choyamba, komanso makamaka, kubwereza mtima kokhazikika. Sitikulimbikitsidwa kuti mupume. Tengani piritsi limodzi nthawi yomweyo tsiku lililonse. Phunzirani nkhani yayikulu yama statins. Amapereka njira zomveka bwino za omwe ayenera kumwa mankhwalawa ndi omwe samamwa.

Krestor, monga ma statin ena, sanapangidwire maphunziro apamwamba. Anthu omwe ali ndi zisonyezo zakugwiritsa ntchito kwake ayenera kumwa mankhwalawa tsiku lililonse. Ngati mugwiritsa ntchito moyenera mankhwala osokoneza bongo a rosuvastatin, adzakuthandizani kuwonjezera moyo wanu kwa miyezi ingapo kapena zaka. Imalepheretsa chitukuko osati kugunda kwamtima kokha, komanso kukomoka komanso kulumikizana kwapang'onopang'ono. Kuphatikiza pa kumwa mankhwala, samalani ndi moyo wathanzi. Werengani nkhani "Kupewa matenda a mtima ndi sitiroko."

Mtanda, monga ma statin ena, ungayambitse kutopa, kupweteka m'malo ndi minofu. Kuti mumve zambiri, onani nkhani yakuti "Zotsatira zoyipa za ma statin." Nthawi zambiri, phindu la mankhwalawa limakhala lalikulu kuposa zotsatira zake zoyipa. Pokhapokha ngati zotsatira zoyipa sizingalekere, kambiranani ndi dokotala wanu kuchepetsa kuchuluka, kusinthira ku mankhwala ena kapena kufafaniza kwathunthu kwama statins.

Onaninso vidiyo ya "Cholesterol Statins: Odwala Odwala."

Rosuvastatin imatha kumwa pamimba yopanda kanthu kapena mukatha kudya, monga mungafunire. Sipadzakhala kusiyana pakumwedwa kwa mankhwalawo komanso momwe zimakhudzira m'mimba. Ngati mukukhala ndi nkhawa ndi zovuta za mapiritsi a Krestor, ndiye kuti kuzichotsa sikungathandize. Chifukwa mutayambiranso mankhwalawo, mavuto ake amayambanso kubwereranso. Funsani dokotala wanu choti achite.

Kodi mungalangize analogue yotsika mtengo yaku Russia?

Krestor ndi mankhwala oyamba, omwe amatengedwa kuti ndi abwino kwambiri pakati pa kukonzekera kwa rosuvastatin. Tsoka ilo, ili ndi mtengo wokwera kwambiri kotero kuti sitha kufikira odwala ambiri. Zoyenera bwino ndi mapiritsi a rosuvastatin opangidwa ku Eastern Europe. Samalani ndi kukonzekera Mertenil, Roxer ndi Rosucard. Amapangidwa ndi makampani otchuka azamankhwala malinga ndi miyezo yokhwima ya EU.

Pali mitundu yotsika mtengo ya mankhwala Krestor omwe amapangidwa ku Russia Federation ndi mayiko a CIS. Awa ndi mapiritsi a rosuvastatin, omwe amapangidwa ndi Severnaya Zvezda, Pharmstandart-Tomskkhimfarm (Akorta), Canonfarm Production ndi ena. Katswiri wodziwa za mtima walimbikitsa kupatsa chidwi ndi mankhwala omwe amapangidwa ku Eastern Europe. Werengani zambiri apa. Analogs opanga ku Russian Federation ndi mayiko a CIS, komanso amwenye, ndibwino kuti asagwiritse ntchito, ngakhale ali ndi mtengo wotsika.

Kodi ndingagawe piritsi la Krestor pakati?

Mosavomerezeka, simungathe kugawanitsa mapiritsi a Krestor pakati. Palibe mzere wogawanika pa iwo. Mosasamala - mutha kugawana mapiritsi, koma ndibwinonso. Chifukwa kunyumba, simudzatha kugawa piritsi lanu magawo awiri ofanana. Palibe ngakhale lumo lomwe lingathandize, ndipo makamaka ngati lingagwiritsidwe ntchito ndi mpeni. Muyenera kumwa mankhwalawa mosiyanasiyana tsiku lililonse. Izi zikuchulukitsa zotsatira za chithandizo.

Mlingo wa Krestor 5 mg patsiku sunayesedwe mu maphunziro alionse azachipatala. Iyenera kukhala yotsika kwambiri, osati yotsika kolesterol "yoyipa" yochepa ndikuteteza modzikuza mtima. Musagawe piritsi ya 10 mg ya rosuvastatin pakati kuti mutenge 5 mg patsiku. Anthu ena amagula mankhwala okwera mtengo pamankhwala akuluakulu, kenako amawagawa pakati kuti piritsi lililonse limatha kwa masiku awiri. Osamachita izi ndi mapiritsi a Krestor. Iyi ndi njira yoopsa yosungira ndalama.

Crestor kapena atorvastatin: ndibwino?

Krestor ndi dzina lamalonda lamankhwala lomwe mankhwala ake amagwiritsidwa ntchito ndi rosuvastatin. Atorvastatin ndi mankhwala enanso omwe amachepetsa cholesterol "yoyipa". Imachita mpikisano ndi rosuvastatin. Anthu omwe akufuna kumwa mankhwala abwino kwambiri a rosuvastatin amasankha Crestor. Chifukwa awa ndi mankhwala oyamba, omwe amawonedwa ngati apamwamba kwambiri. Nthawi yomweyo, atorvastatin ndibwino kwa odwala ena kuposa rosuvastatin. Makamaka, izi zimagwira ntchito kwa odwala omwe ali ndi matenda omwe ali ndi vuto la impso. Atorvastatin zowalepheretsa kuposa rosuvastatin.

Odwala sayenera kusankha okha pakati pa rosuvastatin ndi atorvastatin. Izi ziyenera kukhudzidwa ndi adokotala. Amasankha mulingo woyenera wa mankhwala a cholesterol, kenako ndikuwonjezera kapena kuuchepetsa malinga ndi zotsatira za kuyezetsa magazi. Komabe, ndizomveka kuti odwala athe kuwerengera tsatanetsatane pa atorvastatin ndi rosuvastatin pa Centr-Zdorovja.Com. Mankhwala oyamba a atorvastatin amatchedwa Liprimar.

Krestor kapena Liprimar: ndibwino kuvomereza chiyani?

Krestor ndiye woyamba mankhwala a rosuvastatin, ndipo Liprimar ndiye mankhwala oyamba a atorvastatin. Anthu omwe akufuna kumwa mapiritsi abwino kwambiri a cholesterol ayenera kulabadira awa onse mankhwalawa. Chisankho pakati pa rosuvastatin ndi atorvastatin chikufotokozedwa poyankha funso lakale. Osapanga izi nokha, kambiranani ndi dokotala. Krestor ndi Liprimar onse ali ndi anzawo abwino opangidwa ku Eastern Europe, omwe amaphatikiza mtengo wotsika mtengo komanso wapamwamba.

Crestor kapena Mertenil: zili bwino ndi chiyani?

Krestor - mankhwala oyambirira a rosuvastatin, wapamwamba kwambiri. Mertenil ndi amodzi mwa fanizo lake. Mapiritsi a Mertenil amapangidwa ndi Gedeon Richter, makamaka ku Hungary. Fotokozerani dziko lomwe anachokerako ndi barcode pa paketi la mankhwala. Zokonzekera zomwe zimapangidwa m'maiko a EU nthawi zambiri zimakhala zabwino. Odwala omwe akufuna kumwa mankhwala abwino kwambiri a rosuvastatin amasankha Crestor. Ngati mukufuna kuchepetsa mtengo wa chithandizo, samalani ndi Mertenil ndi ma analogu ena opangidwa ku Eastern Europe. Ngakhale mapiritsi a rosuvastatin otsika mtengo akupezeka ku Russia Federation ndi mayiko a CIS.

Ndakhala ndikutenga Krestor kwa zaka 6 pambuyo povulala mtima. Posachedwa ndidazindikira kuti kukumbukira kwakanthawi kukuchepa. Kodi izi ndizoyipa zamankhwala? Zoyenera kuchita

Mavuto amakumbukiro ndi malingaliro ndizotsatira zoyipa za ma statins, zomwe makampani azamalonda amawoneka kuti kulibe. Zoyenera kuchita - phunzirani za mapuloteni othandizira. Yesetsani kuchepetsa kutupa kosafunikira m'matumbo mwa njira zachilengedwe, monga tafotokozera m'nkhaniyi "Kupewa matenda a mtima komanso sitiroko." Ngati mutha kuchita izi ndipo mapuloteni anu a C-reactive amakhalanso abwinobwino, ndiye kuti perekani ma statins, ngakhale akhale ndi cholesterol yayikulu ya LDL.

Kodi rosuvastatin angayambitse kupweteka kwa minofu, kulemera kwa mwendo, kutopa, kukokana kwa mwendo?

Zizindikiro zanu zonse zimayamba chifukwa chotenga mapiritsi a Krestor kapena ma statin ena. Momwe mungachepetsera zoyipa zama statins kapena kuzichotseratu, werengani apa. Khalani ndi magazi ndi mkodzo poyesa momwe impso yanu imagwirira ntchito. Ngati chilichonse chikhala bwino ndi impso zanu, ndiye kuti mupeze mankhwala a magnesium-B6 pamiyendo.

Mupezanso zambiri zothandiza patsamba la "Statins: FAQ. Mayankho a mafunso a odwala. "

Kugwiritsa ntchito mankhwala Crestor

Krestor ndi mankhwala oyamba omwe amawonedwa kuti ndi abwino kuposa mapiritsi a rosuvastatin kuchokera kwa ena opanga. Mankhwalawa amathandizira kusintha magazi a cholesterol, kuletsa kukula kwa atherosulinosis komanso kusintha. Rosuvastatin yatsimikiziridwa kuti ichepetsa chiwopsezo cha matenda a mtima, komanso ischemic stroke, mavuto amiyendo, ndi mawonekedwe ena a atherosulinosis. Mankhwalawa ndi m'gulu la mankhwala otchedwa statins. Odwala omwe amatenga ma statins, nthawi zambiri pamakhala kufunika kopititsa magazi mwamphamvu m'mitsempha yotsekeka chifukwa cha cholesterol plaque.

Amakhulupirira kuti rosuvastatin ndi ma statin ena amachepetsa kugunda kwa mtima ndi sitiroko, chifukwa amachepetsa cholesterol "yoyipa" m'magazi. Malingaliro enanso - tanthauzo lalikulu la mankhwalawa ndikuchepetsa kutupa kosafunikira. Kutupa pakasowa, ma atherosselotic plaques amasiya kukula, ngakhale LDL cholesterol ikadali yokwera. Malingaliro awa adawonetsedwa koyamba munkhani "C-reactive protein ndi zina zolemba za kutupa pakulosera zam'kati mwa azimayi" mu Marichi 2000 New England Journal of Medicine. Kuyambira nthawi imeneyo, lakhala likuwoneka kwambiri pakati pa madotolo odziwika komanso makamaka pakati pa oimira mankhwala ena.

Mlingo wa kutupa nthawi zambiri umayesedwa pogwiritsa ntchito kuyezetsa magazi kwa protein yokhala ndi C. Kulimba kwamphamvu kapena kutupika kwamphamvu, kumakuliraku. Mu 2008, zotsatira za kafukufuku wa JUPITER ndi odwala 17 802 zidasindikizidwa. Zinadziwika kuti ndi bwino kupereka mapiritsi a rosuvastatin kwa okalamba ndi achikulire omwe ali ndi mapuloteni ambiri a C, ngakhale atakhala ndi cholesterol yokhazikika. Kafukufuku wa JUPITER adawonetsa kuti mwa odwala, rosuvastatin amachepetsa chiopsezo cha kugunda kwamtima, kugunda kwa mtima ndi mavuto ena amtima pafupifupi kawiri. Zambiri za phunziroli zafotokozedwa pansipa muchigawo chakugwiritsa ntchito mankhwala a Krestor ku matenda a mtima.

Dipatimenti ya US Department of Health (FDA) yatenga lingaliro pa zotsatira za kafukufuku wa JUPITER. Kuzomwe zikuwonetsa ntchito za rosuvastatin zidawonjezeredwa: kuchuluka kwa mapuloteni a C omwe amachititsa kuti munthu akhale ndi chiopsezo cha mtima, ngakhale kuchuluka kwa mafuta m'thupi kumakhala kokhazikika. Krestor anali woyamba komanso pakadali pano statin yokha yolandila chidziwitso kuti agwiritse ntchito. Izi zakulitsa msika wake. Odwala ayenera kudziwa kuti ma statins ena (atorvastatin, simvastatin, lovastatin) amachepetsa kutupa, kusintha mapuloteni a C omwe amathandizira. Koma ma Patent a mankhwalawa adatha nthawi yayitali. Chifukwa chake, palibe amene adayamba kulipira ndikuyambitsa maphunziro okwera mtengo a anti-kutupa zotsatira za statins zam'badwo wapitawu.

Kuchepetsa Kutsika kwa Cholesterol

Crestor ndi ena opanga mapiritsi a rosuvastatin amatsitsa cholesterol "choyipa" cha LDL kuposa ma statins akale. Target low LDL cholesterol imafika ku 64-81% ya odwala omwe amamwa mankhwalawa. Pakati pa anthu omwe amatenga ma statin ena, 34-73%. Funso lina ndikuti zimakhala bwanji. Chiphunzitso chomwe takambirana pamwambapa ndikuti chithandizo chachikulu cha ma statins ndikuchepetsa kutupa.Akatswiri omwe ali ndi malingaliro awa amakhulupirira kuti kutsitsa cholesterol ya LDL ndi zotsatira zoyipa zomwe sizikugwirizana ndi kuchepetsa chiopsezo cha kugunda kwa mtima ndi sitiroko. Mapuloteni a C-reactive ndi chizindikiro china cha kutupa amafunikira kuyang'aniridwa mosamala kuposa cholesterol. Chithandizo chachikulu chimawerengedwa ngati chakudya komanso zolimbitsa thupi. Musayesere kusintha kusintha kuti mukhale ndi moyo wathanzi ndi mankhwala a Krestor kapena mapiritsi ena aliwonse.

Kuti akwaniritse kuchepa komweko kwa LDL cholesterol, monga kumwa atorvastatin, rosuvastatin amalembedwa kwa odwala omwe amapezeka katatu. Nthawi zambiri amayamba ndi 10 mg ngakhale 5 mg patsiku. Ma Statist omwe adamasulidwa pamsika koyambirira kuposa Krestor amatengedwa pamtengo wokwera. Ngakhale izi, mankhwala am'mibadwo yam'mbuyo amachepetsa cholesterol "yoyipa" chichepera. Ndizoyenera kukumbukira apa kuti LDL cholesterol siyowopsa, koma chinthu chofunikira. Amuna ndi akazi ogonana amapangidwa kuchokera pamenepo, ndikofunikanso ku ubongo. Kuchepetsa kwambiri “choletsa” cholesterol kumawonjezera mwayi wa kukhumudwa, ngozi zagalimoto ndi kufa pazifukwa zonse. Phunzirani cholesterol ya amuna ndi akazi pazaka. Chifukwa cha izi, mumvetsetsa chifukwa chomwe adokotala amawonjezera kuchuluka kwa mapiritsi a rosuvastatin kapena, motsika, amatsitsa. Kuti muchepetse cholesterol yanu "yoyipa" komanso "yabwino" komanso triglycerides, sinthani ku chakudya chamafuta ochepa. Izi zikuthandizani kuti muchepetse kuchuluka kwa ma statins, kapena kuwasiya kwathunthu.

Minidoses ya valsartan ndi fluvastatin, omwe ali ndi maphunziro apafupi komanso osowa, amasintha zaka zamagazi.

Maphunziro 5 azachipatala kuyambira 2011, 2012, 2013, 2014 2015 mwa anthu awonetsa kuti chithandizo ndi kuphatikiza kwa valsartan (sartan) 20 mg + fluvastatin (statin) 10-20 mg - mu Mlingo wochepa wa mwezi umodzi umabwezeretsanso mitsempha yamagazi - imabweza zaka zamagazi asinthidwa ndi zaka pafupifupi 10-15. Ndipo izi zimapitilira kwa miyezi 6-7, pang'onopang'ono kuchepa. Ndipo mukadzabwereza maphunzirowa miyezi isanu ndi umodzi, zotsatira zidzakhala chimodzimodzi.

Chifukwa cha maphunziro apafupi oterewa mumadontho a mini, timapewa zovuta za fluvastatin - kuphatikizapo mtundu wachiwiri wa matenda a shuga. Ndipo izi zitha kutipatsa kale zombo zazing'onoting'ono nthawi zonse. Funso lina - sizodziwikiratu kuti mutha kubwezeretsa nthawi yayitali bwanji ndikukonzanso motere - zaka makumi angapo bwanji? Kuphatikiza apo, njirayi imagwira ntchito mwa anthu athanzi komanso odwala omwe ali ndi matenda a shuga 2, komanso odwala omwe adwala matenda amisala.

Chaka cha 2011. Anthu azaka zapakati paumoyo

Chaka cha 2012. Amuna azaka zapakati

Chaka cha 2013. Anthu azaka zapakati paumoyo

Chaka cha 2013. Odwala odwala matenda ashuga.

Chaka cha 2015. Mwa anthu athanzi apakati komanso achichepere

Njira zina chifukwa chomwe yochepa mapiritsi a minidoses a fluvastatin 20 mg ndi valsartan 20 mg patsiku amasinthanso mitsempha yamagazi, kubweza zaka zawo.

Selo lililonse m'thupi limakhala ndi ma telomeres, kutalika kwake kumachepera ndi gawo lililonse latsopano. Koma kutalika kwa ma telomeres kumatha kuchira mothandizidwa ndi enelme ya telomerase. Mosiyana ndi kubereka, tsinde, komanso masoka ena amthupi ndi maselo a khansa, m'maselo ochepa, telomerase enzyme (yomwe imabwezeretsa kutalika kwa telomere) kulibe, kotero maselo sangathe kugawanika mpaka kalekale, ndipo minyewa yake imatha, imachepetsa nthawi ya moyo wa munthu. Koma 1 mwezi maphunziro a valsartan 20 mg + fluvastatin 10-20 mg. Amachulukitsa kwambiri ntchito ya telomerase ndi nthawi 3.28, yomwe imagwirizana kwambiri ndi ntchito ya endothelial (kukonzanso mitsempha yamagazi) ndi kuchepa kwa kutupa m'mitsempha yamagazi. Ndipo kuchuluka kwakuchulukirako kwa telomerase kumapitirira, pang'onopang'ono kuchepa, miyezi inanso zisanu ndi chimodzi.

Lumikizani phunziroli:

Mphamvu yamkati ikuwonetsa kuuma kwa mitsempha yathu.Zotengerazi ndizakale, zimakhala zolimba kwambiri komanso zowonjezereka zomwe zimayendetsa kuthamanga kwa magazi, zomwe zimayambitsa nkhawa pamtima, kuzidziwikitsa kwa hypertrophy ndi fibrosis.

Lumikizani phunziroli:

Kuti mudziwe kuuma kwa mitsempha, kuthamanga kwa mafunde am'mimba kumayesedwa pogwiritsa ntchito chipangizo chapadera. Kwa anthu azaka zapakati ndi zapakati, kufalikira kwam'mphepete mwa kugunda kwamphamvu mu aorta (mtsempha waukulu wamtima) ndi 5.5-8.0 m / s. Ndi zaka, kutalika kwa makoma a mitsempha kumachepa, ndipo kuthamanga kwa funde limakulirakulira. Chithunzi chomwe chili pamwambapa chikuwonetsa momwe chidziwitso cha kufalikira kwa ma pulse pazida zimawonekera. Koma 1 mwezi maphunziro a valsartan 20 mg + fluvastatin 10-20 mg. amachepetsa kugunda kwamagalasi ndi 11%

Ndi zaka, kuthamanga kwa magazi kukukulira. Izi ndichifukwa choti ntchito ya vasotor endothelium imawipira (kaphatikizidwe ka nitric oxide m'makoma amitsempha amachepa). Mwakutero, nitric oxide ndi imodzi mwama "dilators" ofunika kwambiri a mitsempha poyankha kuwonjezeka kwa magazi kuti achepetse.

Ndipo tsopano - mwezi umodzi wa valsartan 20 mg + fluvastatin 10-20 mg. Amakhala ndi madzi othandiza pakuyenda bwino kwamitsempha ndi 170%. (flow-mediated dilatation) ikuwonetsa kuchuluka kwa chotengera, ndikuti kupanga kwa nitric oxide (NO) m'matumba kuli).

Kuphatikiza apo, maphunziro a mwezi umodzi wa valsartan 20 mg + fluvastatin 10-20 mg. amachepetsa β kukhuthala kwa chotupa cham'kati mwa carotid ndi 12%

Zombo zapamtima - iyi ndiye mkati mwa zotengera zomwe zimayenda mkati mwa mkati. Makulidwe ake ndi chizindikiro cha zaka zamitsempha yamagazi. Ichi ndi chimodzi mwamawonekedwe a msana wamitsempha, koma chofunikira kwambiri. Zoonadi, zocheperako zimachepera m'mitsempha, ndipamenenso magazi amayenderera mtsempha. Chithunzicho chakumanzere chikuwonetsa chida chaching'ono, ndipo kumanja - chachikulire, momwe makulidwe a makina azowonjezera amakula kwambiri. Zikuwoneka chifukwa cha zolembedwa za atherosselotic. Zotsatira zake, chiwonetserochi chimachepetsedwa, ndipo magazi amayenda kudzera m'chiwiya chotere.

Ndipo apa pali kosi ya mwezi umodzi wa valsartan 20 mg + fluvastatin 10-20 mg. mwamphamvu amachepetsa makulidwe a ziwiya zama media. Koma m'magawo awa momwe cholesterol plaque amadziunjikira

Zotsatira izi zinali zofunikira kwambiri pamlingo wokwera kwambiri. Ndipo palibe zoyipa zomwe zimawonedwa mwa aliyense mwa omwe adachita kafukufukuyu. Chosangalatsa ndichakuti zotsalira zomwe zidasinthazi zidatenga miyezi 6-7. Kubwereza kuzungulira koteroko kumatha kusungira zaka zocheperako pamtunda wofanana kwa zaka zambiri.

Kafukufuku wazathu payekha

Masiku ano, anzathu ena akuchita valartan 20 mg maphunziro a 2 mwezi. + fluvastatin 20 mg. kutsatira yopuma. Kosi ya miyezi iwiri ya sartans yomwe ili ndi statins idafunsidwa ndi wasayansi Alexander Fedintsev (wolemba buku la zasayansi pakutsimikiza kwa zaka zam'biri, wolemba-buku la buku lotchedwa "Potential Heroprotectors" ndi ntchito zina zambiri zasayansi pantchito yakukulitsa moyo. Alexander Fedintsev anali m'modzi mwa oyamba kupeza kuthekera kwa sartans kutalikitsa moyo), ogwira ntchito kwambiri kuposa mwezi umodzi. Ndipo m'modzi mwa anzathu (omwe ali ndi zaka 40) adachita maphunziro a miyezi iwiri (Valsartan 20 mg + fluvastatin 20 mg). Asanayambe maphunzirowo, mothandizidwa ndi Alexander Fedintsev, adapanga chosinthika cha mtsempha wama carotid ndikuyesa kukula kwa chipangizo cha media. Makulidwe a chotengera sayenera kupitirira 1.2 mm. Kupitilira gawo ili kukuwonetsa chiyambi cha kusintha kwa ma atherosselotic. - Ichi ndiye chiyambi cha njira ya atherosselotic. Pambuyo pa maphunzirowo, makulidwe a khoma lamanja la carotid artery adakhala 0.6 mm. - halved. Anasinthiratu mitsempha yake yamwazi - adazunguliranso zaka za mtsempha wamagazi.

Maphunziro a nyama amaphatikiza valsartan + fluvastatin

Zotsatira izi zinalimbikitsidwanso m'maphunziro a nyama kuti afotokozere zomwe zimapangitsa kuti zinthu zisinthe. Chifukwa chake, valsartan + fluvastatin, pakanthawi kochepa mumaminidos, amachepetsa mawu a endothelin mtundu A receptors (EDNRA), ndipo mawu a endothelial nitric oxide synthase 3 (NOS3) amawonjezeka.

Lumikizani phunziroli:

Analogs ndi yogwira pophika Simvastatin

Kuphatikiza pa atorvastatin, gawo logwira popanga simvastatin limagwiritsidwa ntchito mu lipid-kuchepetsa mankhwala.

Mankhwala ozikidwa pompopompo ndi a m'badwo woyamba wama statins ndikuwapatsa mankhwala a mtima, komanso matenda amitsempha yamagazi.

Ma Analogs a Liprimar kutengera gawo la simvastatin, pali mankhwala monga awa:

Mankhwalawa amapangidwa ku Slovenia Vasilip,
Chithandizo cha Chidatchi Zokor,
Wopanga waku Czech mankhwala Simgal.

Zokor Simgal Vasilip

Analogs kutengera chigawo cha rosuvastatin

Kukonzekera kutengera yogwira pophika rosuvastatin a m'badwo wachinayi wa ma statins.

M'badwo uno wama statins ulibe mphamvu zoyipa mthupi, chifukwa zimagwiritsidwa ntchito ngakhale mu matenda a chiwindi, komanso impso ndi kwamikodzo.

Ndi malo ake, rosuvastatin ndi ofanana ndi gawo la atorvastatin. Rosuvastatin imalowa mkatikati mwa thupi ndikuyamba kupanga zoletsa.

Nthawi zambiri, zotsatirazi zamankhwala zotsatira za Liprimar zimagwiritsidwa ntchito:

Analogue Crestor kupanga Great Britain,
Njira zopangira Hungary Mertenil,
Chithandizo cha Israeli Tevastor.

Crest Mertenil Tevastor

Mitengo ya Analog

Zofananira zonse ndi cholowa m'malo mwa mankhwala a Liprimar zimangoperekedwa ndi adokotala omwe amatha, mwachitsanzo, mankhwala a Torvakard, kapena Krestor, omwe ndi abwino kwa wodwalayo.

Pazodzisamalira nokha, ma statins siabwino, chifukwa kukhala ndi vuto lalikulu mthupi, mutha kuvulaza thanzi kuposa kupeza phindu kuchokera ku ma statins.

Gome limawonetsa mitengo ya mankhwala omwe nthawi zambiri amalembera hypercholesterolemia:

dzina lamankhwala	gawo yogwira	Mlingo wa mankhwala	mtengo muma ruble aku Russia
mankhwala Liprimar	atorvastatin thunthu	10,0 mg - 100 tabu.,	· 1720,00.
80.0 mg - 30 mapiritsi	· 1300,00.
Mankhwala a Atorvastatin	atorvastatin thunthu	10,0 mg - mapiritsi 30,	· 190,00.
40.0 mg - mapiritsi 30	· 300,00.
Mankhwala a Atoris	atorvastatin thunthu	10,0 mg - mapiritsi 30,	· 690,00.
40.0 mg - mapiritsi 30	· 520,00.
mankhwala Torvakard	atorvastatin thunthu	10,0 mg - mapiritsi 30,	· 780,00.
40.0 mg - mapiritsi 30	· 590,00.
tulip mankhwala	atorvastatin thunthu	10,0 mg - mapiritsi 30,	· 680,00.
40.0 mg - mapiritsi 30	· 500,00.
mankhwala crestor	gawo la rosuvastatin	10,0 mg - mapiritsi 28,	· 1990,00.
40.0 mg - mapiritsi 28	· 4400,00.
Mankhwala a Mertenil	gawo la rosuvastatin	10,0 mg - mapiritsi 30,	· 600,00.
40.0 mg - mapiritsi 30	· 1380,00.
Kutanthauza Tevastor	gawo la rosuvastatin	10,0 mg - mapiritsi 30,	· 485,00.
20,0 mg - mapiritsi 30	· 640,00.
mankhwala vasilip	mankhwala a simvastatin	10,0 mg - mapiritsi 28,	· 280,00.
40.0 mg - mapiritsi 28	· 580,00.
mankhwala Zokor	gawo la simvastatin	40.0 mg - 14 tabu.	· 460,00.

Ndemanga za Liprimar

Galina, wazaka 42, ku Moscow: adotolo andipangira mankhwala Liprimar. Pambuyo pa milungu itatu ya maphunziro anga, kupezeka kwa mankhwalawa kunayamba kuchepa kwa mafuta m'thupi.

Koma mtengo wa Liprimar ndiwokwera kwambiri, motero ndidafunsa adotolo kuti andibwezeretse ndi ma analogues. Ndinayamba kutenga analogi, koma sizinabweretse zotere monga Liprimar, motero ndinabwereranso ku kutenga statin yoyambayo.

Pokhapokha nditamwa mankhwala ofanana, ndinayamba kumva zovuta zomwe sindimamva ndikumwa mapiritsi a Liprimar.

Nikolay, wazaka 54, Orenburg: Ndakhala ndikulimbana ndi cholesterol yayikulu kwa zaka 6. Ma Statin amayenera kukhala oledzera pafupipafupi, chifukwa atasiya kudya, mafuta m'thupi amayambiranso.

Pa nthawi yonse ya mankhwalawa, ndimamwa mapiritsi osiyanasiyana komanso mitundu yosiyanasiyana ya ma statins, koma mankhwala a Liprimar amawonetsa zabwino.

Mtengo wokha wa mankhwalawa ndiwokwera kwambiri. Kwa ine, adotolo adasinthanitsa mankhwalawa ndi ma analogues. Ndimamwa analogue ya Liprimar kwa mwezi umodzi ndipo sindikuwona kusiyana pakati pa analogue ndi koyambirira. Mphamvu yakuchiritsa ndi yomweyo.

Matenda a mtima

Krestor amachepetsa kukulitsa kwa coronary atherosulinosis, yomwe imapangitsa kuti matendawa azikhala kwa odwala omwe ali ndi matenda a mtima. Amanenedwa pamwambapa kuti ma statins a m'badwo wa III ndi IV - rosuvastatin ndi atorvastatin - samangoletsa mawonekedwe a cholesterol malo atsopano, komanso amachepetsa kukula kwa omwe apanga kale. Mwinanso, chithandizo cha mankhwalawa chimachepetsa chiopsezo cha mavuto a mtima, komanso kusokonezeka kwa kufalikira kwa ubongo, kupweteka kwamiyendo, ndi mawonekedwe ena a systemic atherosulinosis.

Maziko a umboni wa mankhwala a Crestor anali kafukufuku wa JUPITER, zomwe zotsatira zake zidafalitsidwa mu 2008. Phunziroli lidakhudza odwala opitilira 15,000. Theka laiwo anali atamwa mankhwala oyamba a rosuvastatin pa 20 mg patsiku, ndipo theka lachiwiri linapatsidwa placebo. Mwa anthu omwe adamwa mankhwala enieni, cholesterol "yoyipa" ya LDL idatsika pafupifupi 50%, triglycerides - ndi 17%, mapuloteni a C-37%. Koma koposa zonse, kufupika kwa matenda amtima kwachepa kwambiri.

Chizindikiro	Rosuvastatin	Malo
Chiwerengero cha odwala	8901	8901
Myocardial infaration	31	68
Stenting, coronary bypass opaleshoni	71	131
Kugonekedwa kuchipatala chifukwa cha angina osakhazikika	16	27
Kufa kwathunthu	198	247

Monga mukuwonera, kutenga rosuvastatin kwambiri kunachepetsa chiopsezo cha matenda a mtima. Ophunzira onse adalandira mankhwala oyambira a AstraZeneca Crestor. Palibe chidziwitso chokwanira ngati mapiritsi a rosuvastatin a ena opanga ali ndi zotere. Phunziroli la JUPITER limatsutsidwa chifukwa chotsirizidwa pasadakhale - zaka 2, osati zaka 5 monga momwe anakonzera. Ngati phunziroli lidatha zaka 5, ndiye kuti kusiyana pakati pa zidziwitso zomwe zili mu rosuvastatin ndi magulu a placebo sikukhala kofunika kwambiri.

Odwala omwe apezeka ndi matenda a mtima ndi anthu omwe ali ndi chiopsezo chamtima kwambiri. Afunika kutenga Krestor kapena ma statin ena kuti achepetse vuto la kugunda kwa mtima ndi sitiroko. Phindu la mankhwala a statin lidzakhala lokwera kuposa zovuta zomwe zingakhale ndi mavuto. Phunzirani nkhani ya: “Kuthana ndi Vutoli la Mtima ndi Mikwingwirima” ndikutsatira njira zomwe zafotokozedwamo. Kumwa mankhwala, ngakhale apamwamba kwambiri komanso okwera mtengo, sangathe kusintha moyo wamunthuyo. Mapiritsi amangowonjezera chakudya, masewera olimbitsa thupi komanso kuchepetsa nkhawa.

Zotsatira zina zabwino zamaphunziro osowa ndi ma minidoses a statins + sartans

Valsartan + fluvastatin amachepetsa chiopsezo cha fibrillation ya atria, komanso amachepetsa fibrosis yamisempha yamtima, chifukwa cha kukalamba kwa mtima chifukwa cha matenda ashuga a mtima. Njirayi yalumikizidwa ndi kulepheretsa kuwonetsa kwa TGF beta.

Lumikizani phunziroli:

Lipophilic statins (fluvastatin, simvastatin, etc.) amachepetsa chiopsezo cha kufa ndi khansa yamapapu ndi 11-20%.

Lumikizani phunziroli:

Amodzi mwa ma statins (simvastatin) ndi othandizira kwambiri othandizira odwala omwe ali ndi nkhawa komanso kupsinjika kwakukulu, komanso kuwonjezera pa chithandizo cha matenda a schizophrenia - poletsa kutupa m'mitsempha.

Lumikizani phunziroli:

Statins ndi zamphamvu neuroprotective ndi neuromodulating zinthu zomwe zingateteze ubongo ku ukalamba. Amawonjezera kutsekeka komanso kutsekeka kwa nembanemba, kukulitsa kukana kwa maselo aubongo kuzinthu zoyipa. Matenda amasintha kukumbukira osati achikulire, komanso mwa achinyamata omwe amakhala ndi nkhawa. Statins amasintha kusinthana kwa monoamines (dopamine, norepinephrine, serotonin). Monoamines amagwirizanitsidwa kwambiri ndi kusokonezeka kwa malingaliro ndi malingaliro.Ma Statin ali ndi mphamvu yotsutsa-yotupa mu ubongo mu kukhumudwa ndi schizophrenia. Statins imaletsanso zotupa m'matenda a autoimmune monga psoriasis ndi nyamakazi.

Maulalo Ofufuza:

Lipophilic statins (fluvastatin, lovastatin, simvastatin, atorvastatin) ali ndi anti-cancer yambiri. Chifukwa chake, 1-2-mwezi maphunziro a valsartan 20 mg + fluvastatin 20 mg amathanso kuchepetsa chiopsezo cha khansa.

Lumikizani phunziroli:

Njira yakukonzanso mitsempha yamagazi ndikuletsa kukalamba kwawo kwa anthu omwe alibe vuto la kuthamanga kwa magazi zitha kuwoneka motere:

Miyezi iwiri yoyambirira: Valsartan (Valz) 20 mg + fluvastatin (Leskol) 20 mg - ndi chilolezo cha dokotala.
Kuyambira lachitatu mpaka mwezi wachisanu ndi chimodzi: propranolol (anaprilin) kapena carvedilol mu mini Mlingo, kapena kusinthana kwawo - pakalibe zotsutsana, ndi chilolezo cha dokotala. Ngati pali zotsutsana, ndiye kuti kuyambira miyezi itatu mpaka isanu ndi umodzi sitimamwa propranolol (anaprilin) kapena carvedilol ndipo osabweza china chilichonse.

Mwezi woyamba: Valsartan 20 mg + fluvastatin 20 mg - ndi chilolezo cha dokotala.
Mwezi wachiwiri: Telmisartan 10-20 mg + fluvastatin 20 mg - ndi chilolezo cha dokotala.
Kuyambira lachitatu mpaka mwezi wachisanu ndi chimodzi: propranolol (anaprilin) kapena carvedilol mu mini Mlingo, kapena kusinthana kwawo - pakalibe zotsutsana, ndi chilolezo cha dokotala. Ngati pali zotsutsana, ndiye kuti kuyambira miyezi itatu mpaka isanu ndi umodzi sitimamwa propranolol (anaprilin) kapena carvedilol ndipo osabweza china chilichonse.

Kenako timabwerezanso kuzungulira kwathunthu.

Njira yochepetsera kukalamba kwambiri mu mtima kwa anthu omwe ali ndi kuthamanga kwa magazi imatha kuoneka motere:

Miyezi iwiri yoyambirira: mankhwala othandizira kuthamanga kwa magazi omwe amalembedwa ndi dokotala + fluvastatin 20 mg - mothandizidwa ndi dokotala.
Kuyambira lachitatu mpaka mwezi wachisanu ndi chimodzi: mankhwala othandizira kuthamanga kwa magazi omwe amaperekedwa ndi dokotala.

Chenjezo: Mlingo wokhazikika wa ma statin omwe amatengedwa mosalekeza ungayambitse zovuta zoyipa ndikuyambitsa matenda a shuga a 2. Chifukwa chake, zonse pamwambazi zimangogwira ntchito pazosowa zochepa za ma statins mu mini mini. Ndipo musanagwiritse ntchito, muyenera kufunsa dokotala.

Pambuyo pake:

Lero, zotsatira zoyambirira zakukhululuka bwino kwa matenda a Alzheimer mwa anthu zawonekera. Tsopano taphunzira pang'ono momwe tingayang'anire misempha yamagazi ndi mtima. Chotsatira ndi chiyani? Sayansi imatipatsa njira zosangalatsa komanso zosangalatsa zokulitsira moyo. Cholinga chathu chachikulu ndi kuthana ndi kukalamba, zomwe mwakusazindikira kwathu timazipeza lero mwanjira yachilengedwe. Koma mtsogolomo, titha kuchenjeza bwinobwino ndipo nthawi zonse tiyenera kukhalabe achichepere.

Pa chithunzichi, wofufuza wasayansi Alexander Fedintsev (wogwirizanitsa kafukufuku pa Research Institute of Antimicrobial Chemotherapy) akuphunzira mwakhama ma sartan ndi momwe amathandizira pakuyembekeza kukhala ndi moyo. Ndi m'modzi mwa oyamba ku Russia omwe akuyesera kuti atulutse mwayi wa gulu ili la mankhwala kuti atalitse moyo.

Ndithokozanso wofufuza Vladimir Milovanov chifukwa chazidziwitso zofunikira patsamba lino. Ndipo ndikuthokoza wowerenga blog, Alexander K, chifukwa cholumikizana ndi kafukufuku wokhudza kutalika kwa moyo ndi simvastatin + ramipril pa mbewa zokhala ndi moyo wautali.

Tikukupemphani kuti mulembetse ku nkhani zaposachedwa kwambiri komanso zaposachedwa zomwe zikuwoneka mu sayansi, komanso nkhani ya gulu lathu la sayansi ndi maphunziro, kuti musaphonye chilichonse.

Okondedwa owerenga zothandizira www.nestarenie.ru. Ngati mukuganiza kuti zolemba za gwero ili ndizothandiza kwa inu, ndipo mukufuna kuti anthu ena agwiritse ntchito izi kwa zaka zambiri, ndiye kuti muli ndi mwayi wothandizanso kukhazikitsa tsambali pogwiritsa ntchito pafupifupi mphindi ziwiri za nthawi yanu pazinthu izi. Kuti muchite izi, dinani patsamba ili.

Timalimbikitsanso kuwerenga zolemba zotsatirazi:

Metformin ndi mankhwala omwe amaphunziridwa kwambiri omwe amatha kukhala ndi moyo wambiri ngati atchulidwa ndi dokotala kuti amvetse.
Dongosolo lakuwonjezera moyo mwanjira zomveka mwasayansi.
Vitamini K2 (MK-7) amachepetsa kufa
Vitamini B6 + magnesium imachepetsa kufa ndi 34%
Glucosamine Sulfate imachulukitsa moyo ndipo imateteza ku mitundu yambiri ya khansa
Amakonda Kuletsa Kukalamba
Momwe mungamenyere methylglyoxal - chinthu chomwe chimatilemba.

Ma statins odziwika

Kuchita bwino komanso kugwiritsa ntchito mankhwala ochepetsa mphamvu ya lipid kumangosinthidwa nthawi zonse. Masiku ano m'magawo ogulitsa mankhwalawa pali mankhwala osokoneza bongo:

Lovastatin ndi simvastatin (Vasilip, Simvakard) - oyimira oyambilira a gululi, ndi amibadwo yoyambirira.
Fluvastatin (Leskol) ndi njira yabwinoko yomwe imapangitsanso mavuto.
Atorvastatin (Amvastan, Atoris, Liprimar). Njira yothandiza komanso yamakono, pamaziko omwe mankhwala ambiri amapangidwa.
Rosuvastatin (Crestor, Rosart) - kukula kwaposachedwa kwamakampani opanga mankhwala.

Mankhwala atsopano amawonetsa zotsatira zabwino ndipo amatchulidwa ngati zinthu zina zogwira ntchito sizothandiza. Mitengo yamankhwala ochepetsa lipid imasiyananso - mankhwala osokoneza bongo a rosuvastatin azigula kuposa mankhwala okhala ndi lovastatin.

Pambuyo pa vuto la mtima

Pambuyo vuto la mtima, odwala nthawi zambiri amapatsidwa mankhwala a rosuvastatin kapena ma statin ena kuti achulukitse cholesterol, komanso kuchepetsa kutupa ndi C-yogwira mapuloteni m'magazi. Mankhwala Krestor amachepetsa cholesterol "yoyipa" yochulukirapo kuposa ma statin ena, chifukwa chake imapangitsa chidwi chochulukirapo kwa madokotala ndi odwala. Mu 2000s, mankhwalawa adatsutsidwa chifukwa choti pakadalibe kafukufuku wokwanira pa izo, momwe odwala oopsa, makamaka, omwe anali ndi vuto la mtima, adachitapo kanthu. Mpaka pano, maphunziro otere adachitidwa, zotsatira zawo zalembedwa.

Mu Seputembara 2014, tsamba lomwe lipoti la zotsatira za kafukufuku wa IBIS-4 lidawonekera patsamba la European Society of Cardiology - kuyesa kwa kugwiritsa ntchito mankhwalawa pogwiritsa ntchito mankhwala osokoneza bongo a rosuvastatin mwa odwala atatha kulowetsedwa ndi myocardial infaration ndikukwera kwa gawo la QT. Odwala a 103 amatenga 40 mg rosuvastatin patsiku kuwonjezera pa chithandizo chokwanira. Madotolo adaziyang'anira kwa miyezi 13. Odwala nthawi zonse amayeserera cholesterol. Amakhala ndi ma ultrasound a mitsempha kumayambiriro komanso kumapeto kwa nthawi kuti awone ngati atherosclerosis ikukula.

Mankhwala	Kuwerengera wodwala
Pambuyo masiku 30	Mu chaka
Aspirin	101 (98%)	97 (94%)
Prasugrel (Zotsatira)	79 (77%)	75 (73%)
Clopidrogel	22 (21%)	18 (17%)
Beta blockers	96 (93%)	92 (89%)
ACE zoletsa	73 (71%)	55 (53%)
Rosuvastatin
10 mg	3 (3%)	5 (5%)
20 mg	10 (10%)	21 (20%)
40 mg	84 (82%)	65 (63%)
Atorvastatin
40 mg	3 (3%)	3 (3%)
80 mg	2 (2%)	2 (2%)

Pambuyo pa miyezi 13, malo opangira matenda am'mimba amatsika 85% ya odwala, ndipo mwa 56% mwa onsewa. "Choipa" cholakwika cha LDL m'magazi chinatsika ndi pafupifupi 43%. Asanayambe kafukufuku wa IBIS-4, zabwino za kudziwa kuchuluka kwa ma statins kwa odwala omwe ali ndi vuto la mtima, komanso tsopano kwa iwo omwe anali ndi vuto la mtima, adatsimikiziridwa.

Ischemic stroke

Matendwe, limodzi ndi chiopsezo chodwala mtima, amadziwikanso kuti achepetse kuvulaza. Kafukufuku wa JUPITER adanenedwa pamwambapa, chomwe chidakhala maziko a umboni wa mankhwala a Crestor. Zina mwazotsatira zina zosangalatsa, zidapezeka kuti rosuvastatin adachepetsa chiopsezo cha kugwidwa ndi 51% kwa odwala omwe anali ndi cholesterol yokhazikika koma anali ndi protein yayikulu C m'magazi awo. Mu gulu la odwala omwe akutenga mankhwala oyambirira a rosuvastatin, pafupipafupi matenda a ischemic amachepetsa kwambiri, ndipo kukomoka kwa hemorrhagic sikunachulukane, poyerekeza ndi omwe akutenga placebo.

Kafukufuku wocheperako wasonyeza kuti ndikofunikira kupereka ma statins posachedwa pambuyo pa sitiroko. Koma kwa rosuvastatin, palibe deta yomwe mpaka pano yapezeka. Madokotala ochokera ku South Korea mu 2010 adayesa kuchititsa EUREKA - kuyesa koyambirira kwa rosuvastatin popewa kubwezeretsanso.Koma kafukufukuyu sanachitike, chifukwa sakanatha kunyengerera odwala ambiri kuti achite nawo - anthu osachepera 507 amafunikira. Kampani ya AstraZeneca, wopanga mankhwala a Krestor, sanapeputse izi. Tinaganiza zosamutsa mayeserowa ku China.

Type 2 shuga

Rosuvastatin, monga ma statin ena, amawonjezera shuga m'magazi mwa odwala omwe ali ndi matenda a shuga a 2. Komanso, mankhwalawa amawonjezera chiopsezo chokhala ndi matenda osokoneza bongo kwa odwala omwe ali ndi vuto la metabolism. Nthawi yomweyo, zimabweretsa zabwino, zimachepetsa chiopsezo cha matenda a mtima ndi sitiroko. Palibenso mankhwala ena othandizira pakudya, kupatula ma statin, omwe angathandizenso ndimavuto amtima. Ndikofunikira kuthandizira mosamala mankhwala Krestor kapena mapiritsi ena a cholesterol. Nthawi yomweyo, chitani njira zosavuta kuti shuga wanu azikhala wabwino.

Akatswiri aku Japan apeza kuchuluka kwa atorvastatin ndi rosuvastatin kumachulukitsa shuga wamagazi mwa odwala matenda ashuga. Amayi a matenda a shuga 514 adatenga rosuvastatin, ndipo odwala ena 504 adatenga atorvastatin. Tinayamba ndi mlingo wotsika - Krestor 5 mg patsiku, ndi Liprimar (atorvastatin) 10 mg patsiku. Mlingo wama statins unakulitsidwa pang'onopang'ono mpaka kuthekera kuti muchepetse cholesterol ya LDL kupita pazovomerezeka. Zinapezeka kuti onse mankhwala pafupifupi amachulukitsa shuga kwa odwala matenda ashuga. Kusiyana kwa glucose wa plasma anali 0.16-0.22 mmol / L. Odwala adayang'aniridwa kwa miyezi 12 yokha, kotero amatha kutsata shuga ndi cholesterol, koma osati chiwopsezo cha mtima. Pa mlingo wotsika, atorvastatin ndi rosuvastatin chimodzimodzi adachepetsa cholesterol "choyipa". Adaganiza kuti asachedwe mayeso, chifukwa zakhala zikuwonetsedweratu kuti ma statins amachepetsa chiwopsezo cha kugunda kwa mtima ndi stroke kwa odwala matenda a shuga.

Mu 2015, mtolankhani wovomerezeka wa Lancet adafalitsa zotsatira za kafukufuku wa PLANET I, fanizo lothandiza la atorvastatin ndi rosuvastatin poteteza impso mwa odwala omwe ali ndi matenda a shuga a 2. Phunziroli linakhudza odwala 353. Onse pa nthawi yoyambira phunziroli anali kale ndi vuto lodana ndi matenda ashuga, anali kumwa mankhwala oopsa, kuletsa kukula kwa impso. Ophunzira adagawika m'magulu atatu:

Krestor 10 mg patsiku,
Mankhwala omwewo ndi 40 mg patsiku,
Liprimar 80 mg patsiku.

Atorvastatin anali ndi zotsatira zabwino pa chiŵerengero cha albumin ndi creatinine mu mkodzo wa odwala kuposa rosuvastatin mu Mlingo wa 10 ndi 40 mg patsiku. Zotsatira zoyipa zomwe zimagwirizanitsidwa ndi impso zimakonda kuchitika mgulu la rosuvastatin kuposa mwa odwala omwe adatenga atorvastatin. Zotsatira za kafukufukuyu zitha kulankhula m'malo mwa atorvastatin kwa odwala omwe ali ndi matenda a shuga. Amatha kuonedwa ngati odalirika chifukwa mayesowa adathandizidwa ndi AstraZeneca, wopanga rosuvastatin.

Rosuvastatin ndi ma statin ena amawonjezera mwayi wokhala ndi matenda ashuga odwala omwe ali ndi chiyembekezo cha matendawa. Awa ndi odwala omwe amapezeka ndi metabolic syndrome kapena kulekerera kwa glucose. Metabolic syndrome ndi kuphatikiza kwa zizindikiro: kunenepa kwambiri, kuyika mafuta m'chiuno, matenda oopsa, kuyezetsa magazi kosagwirizana ndi cholesterol ndi triglycerides. Amayi onenepa kwambiri omwe ali kale ndi kusintha kwa kubereka nawonso ali pachiwopsezo cha odwala matenda ashuga. Popewa matenda a shuga, onani nkhani ya metabolic syndrome. Tsatirani ndondomeko zomwe zafotokozedwa pamenepo. Poterepa, pitilizani kumwa ma statins kuti muchepetse chiopsezo cha matenda a mtima komanso sitiroko.

Metabolic syndrome

Kodi metabolic syndrome - onani pamwambapa. Vutoli limakonda kukhala la 2 shuga. Koma nthawi zambiri, matenda ashuga alibe nthawi yopitilira, chifukwa odwala amafa ndi vuto la mtima kapena sitiroko. Metabolic syndrome imapangitsa kwambiri chiopsezo cha mtima.Chifukwa chake, anthu omwe adapatsidwa kuti adziwe izi ayenera kumwa Krestor kapena ma statin ena limodzi ndi mankhwala wamba. Chithandizo chachikulu ndikukhazikitsa njira zomwe zasonyezedwa m'nkhani ya “Kupewa matenda a mtima ndi sitiroko.” Kumwa ma statin, mapiritsi opsinjika, ndi mankhwala ena kumangopangitsa kukhala ndi moyo wathanzi, koma osangoikamo.

Mu 2002-2003, kafukufuku wofanana wa rosuvastatin ndi atorvastatin adachitika ndikupanga nawo 318 odwala omwe adapezeka ndi metabolic syndrome. Akatswiri azindikira momwe ma statin amakhudzira cholesterol "yoyipa" ndi "yabwino" m'magazi, komanso zinthu zina zomwe zingachitike chifukwa cha atherosulinosis yokhudzana ndi cholesterol. Ripoti latsatanetsatane pa kafukufukuyu lidasindikizidwa mu Diabetes Care mu Marichi 2009.

Pambuyo pa masabata 6,%	Pambuyo pa masabata 12,%
Rosuvastatin 10-20 mg patsiku	61	80
Atorvastatin 10-20 mg patsiku	46	59

Kafukufukuyu adawonetsa kuti rosuvastatin mu Mlingo wa 10-20 mg patsiku amasintha mawonekedwe a cholesterol am'magazi kuposa atorvastatin chimodzimodzi. Zinapezekanso kuti Krestor wa mankhwalawa amathandizira mafakitala azinthu zabwino kuposa atorvastatin. Odwala amayang'aniridwa kwa milungu 12 yokha. Amawerengetsa magazi pachiyambipo, kenako patatha milungu 6 komanso mobwerezabwereza kumapeto kwa kafukufukuyu. Ino si nthawi yokwanira kuwunika momwe ngozi ya mtima yasinthira ndi momwe mavuto amathandizira. Koma panthawiyi zinali zokwanira kuwunika momwe mankhwalawa onse amagwirira ntchito kuti ayambitse cholesterol.

Cholesterol Wokwezedwa mwa Ana

Ana ndi achinyamata achulukitsa cholesterol yamagazi kwambiri chifukwa cha matenda obadwa nawo - achibale a hypercholesterolemia. Kuyambira paubwana, ma statin amawerengedwa kuti azichiritsa matendawa. Krestor - weniweni mankhwala a rosuvastatin - ndiye wamphamvu kwambiri kuposa ma statin. Itha kukhala mankhwala oyenera ochizira achibale mu hypercholesterolemia paubwana.

Mu Marichi 2010, nkhani idasindikizidwa mu Journal of the American College of Cardiology, lipoti lazotsatira za kafukufuku wothandiza ndi chitetezo cha rosuvastatin pochiza mabanja a hypercholesterolemia mwa ana. Phunziroli lidakhudza odwala 177 azaka zapakati pa 10 mpaka 17. Zina mwa izo zimasankhidwa Krestor koyamba 5 mg patsiku, ndipo pambuyo pake adakulitsa mlingo mpaka 10 ndi 20 mg patsiku. Panalinso gulu la odwala omwe amatenga placebo, osati mankhwala enieni. Ophunzira adayang'aniridwa kwa chaka chimodzi.

Mlingo watsiku ndi tsiku wa rosuvastatin, mg	Kutsika mu cholesterol "yoyipa" ya LDL,%
5	38
10	45
20	50

Mankhwalawa sanachititse zoyipa zoyipa. Panalibe zopatuka pakukula ndi kukula kwa achinyamata omwe amatenga nawo mbali phunziroli. Onse omwe adatenga mankhwala a Crestor oyambirira. Palibe chidziwitso ngati mapiritsi a rosuvastatin a opanga ena angaperekenso chithandiziro chofananira komanso kulolerana kwa achinyamata omwe ali achinyamata. Kutenga rosuvastatin 5-20 mg patsiku, 40% yokha mwa omwe anali nawo phunzirolo ndi omwe adakwaniritsa cholesterol cha LDL choyenera. Koma mlingo wapamwamba wa mankhwalawa 40 mg patsiku amaletsedwa kwa odwala osakwana zaka 18.

Nkhaniyi ikufotokoza zonse zomwe odwala amafunikira kudziwa pogwiritsa ntchito rosuvastatin kukonza mafuta m'thupi. Odwala omwe ali ndi chiwopsezo cha mtima chachikulu amatenga mankhwala oyamba a Crestor kapena mapiritsi ena a rosuvastatin kupewa matenda oyamba ndi a mtima, ischemic stroke, vuto la mwendo ndi zovuta zina za systemic atherosulinosis. Zotsatira zoyipa za ma statins ndizofanana, koma rosuvastatin ali ndi mfundo zake, zomwe zikufotokozedwa mwatsatanetsatane pamwambapa.

Mpikisano waukulu pakati pa ma statins tsopano ukupita pakati pa m'badwo waposachedwa wa mankhwala - rosuvastatin ndi atorvastatin.Mankhwala apachibale a Crestor komanso mapiritsi a rosuvastatin otsika mtengo omwe amapangidwa ndi makampani opikisana akulimbana pakati pawo. Rosuvastatin imakhudzanso kwambiri cholesterol yamagazi kuposa atorvastatin ndi ma statins ena. Koma m'malo ena azachipatala, atorvastatin amakhalabe mankhwala omwe amakonda. Mukawunika nkhaniyi, mumvetsetsa mwatsatanetsatane nkhaniyi. Kusankha kusankha mankhwala ena kumapangidwa ndi adotolo, poganizira momwe wodwalayo angakwaniritsire. Osadzisilira!

About cholesterol

Cholesterol palokha siyowononga m'thupi la munthu. Amatenga nawo mbali zofunikira kwambiri pakapangidwe kazachilengedwe - kapangidwe ka vitamini D, kapangidwe ka timadzi tating'onoting'ono tothandizanso ma cell (cellid cell). Kuti mugwire ntchito zake, imanyamulidwa kupita nayo ku minyewa kudzera m'magazi, koma osati palokha, koma mothandizidwa ndi mapuloteni apadera. Mavuto omwe amayamba chifukwa cholumikizana amatchedwa lipoproteins.

Lipoproteins ndi ochepa komanso okwera kwambiri. Zoyambazo zimawerengedwa kuti "zoyipa" chifukwa zimayambitsa kuwoneka kwa malo a atherosulinotic chifukwa cha mpweya wa cholesterol. Kwa chachiwiri, izi sizachilendo, zimakhala zazing'ono kukula ndipo zimawoneka kuti "zabwino", chifukwa zimagwira cholesterol yosungirako ndikuitumiza kuti ikonzedwe ku chiwindi.

Cholesterol ndiyofunikira kuti thupi lizigwira ntchito, kokha zowonjezera zimatengedwa ngati matenda. Zowonjezera zomwe zimayikidwa pazitseko zamitsempha yamagazi. Ma lipoproteins apamwamba kwambiri amathandizira kuchotsa iwo kuchokera pamenepo. Kuti mukhale ndi thanzi, ndikofunikira kuti pakhale mitundu yambiri ya "zabwino" komanso kuchepetsa kuchuluka kwa "zoyipa", zomwe ndizomwe mankhwala a statin amachita.

Limagwirira a zochita za statins

Kupewa kwa mapangidwe a atheroscherotic zolembera kumatheka kudzera pazotsatira zotsatirazi:

Pansi cholesterol yonse. Popeza zimapangidwa mwachilengedwe m'maselo a chiwindi, ndizotheka kulimbikitsa kukula kwa njirayi.
Kuchepetsa kuchuluka kwa lipoproteins.
Kuwonjezeka kwa mapuloteni ena “abwino”.

Kuvulaza kwama statins

Kufunika kwa zaka zambiri zamankhwala kumayambitsa mavuto. Odwala adadandaula za:

Matenda a minofu yam'mimba - kufooketsa, kupweteka, ngakhale kuwonongeka kwa ulusi. Izi zimabweretsa kulephera kwa aimpso chifukwa cha kufalikira kwa ma tubules.
Mavuto ndi chiwindi, omwe amayamba chifukwa chakuti ma statins amalimbikitsa ntchito za chiwindi michere kwa nthawi yayitali.
Zizindikiro zopanda pake - kupweteka kwa mutu, kusisita, zotupa pakhungu.
Kuchepetsa kwambiri cholesterol, yomwe imakhala yoipa kwambiri.

Kuphatikiza apo, mankhwala a statin omwe amagwiritsidwa ntchito nthawi yayitali amawonjezera mwayi wa matenda ashuga.

Mutha kuthetsa zovuta zake pochepetsa mlingo wa mankhwalawo kapena kusintha ndi analog. Ndikofunikira kwambiri kuti nthawi ndi nthawi muziyesera owunika kuti muwone momwe chiwindi, impso, minofu ndi ziwalo zina ndi minofu yake zilili.

Ma statin othandiza kwambiri komanso otetezeka

Makampani opanga mankhwala amagwiritsa ntchito ndalama zambiri pokonza njira yazogwirira ntchito. Zomwe zatsopano zapeza zili ndi mwayi woyimira kale komanso zikuyenda bwino. Madokotala amasiyanitsa zinthu ziwiri zomwe zimakwaniritsa zofunikira zamakono:

Atorvastatin ndi mtsogoleri wazachipatala komanso kusankha odwala. Njira ya chithandizo imapereka zotsatira zabwino, zomwe zidatsimikizidwanso ndi mayesero azachipatala. Mutha kusankha mlingo kuchokera 20 mpaka 80 mg. Ubwino woposa m'badwo waposachedwa ndi mtengo wotsika mtengo. Dotoloyo amafotokoza nthawi yomwe adzaikidwe, poganizira kuchuluka kwa kupenda koyamba. Mafuta a cholesterol a mgulu laling'ono lino ndi Torvacard.
Rosuvastatin - imawoneka ngati chinthu chotetezeka komanso chothandiza kwambiri.Pamaziko a chinthu choterocho, Rosucard imapangidwa, yomwe imadziwika ndi zotsatira zamphamvu komanso kuchepetsedwa kwa zotsatira zoyipa. Vuto lalikulu la ma statins ndikuwonongeka kwa minofu minofu, koma sizachilendo kwa mankhwala a mibadwo yaposachedwa. Zotsatira zamankhwala zimadziwika pambuyo pa masabata 1-2 ndipo zimakhazikika mpaka kumapeto kwa maphunziro.

Ma cholesterol achilengedwe

Zakudya zina zimathandizanso kuthetsa ma atherosclerotic plaques. Mapangidwe achilengedwe a cholesterol:

Ascorbic acid.
Mtedza, chimanga.
Mphesa ndi vinyo.
Pertin wokhala ndi masamba ndi zipatso.
Zida zotsitsa lipid zachilengedwe zimapezeka mu nsomba zam'madzi ndi mafuta a masamba.

Zakudya zimatha kusintha zotsatira za mankhwala, komabe, zimatsatira zakudya zapadera za moyo. Ma statins achilengedwe amathanso kugwiritsidwa ntchito ngati prophylactic. Njira zina ndi kuchira ndi mankhwala azitsamba ndizothandiza kwa anthu omwe ali pachiwopsezo (kukhala ndi cholowa chamtsogolo, matenda amtima, kunenepa kwambiri, utsi).

Ku Russia, mutha kupeza mitundu ingapo ya mankhwala a cholesterol:

Atorvastatin
Simvastatin
Rosuvostatin
Lovastatin
Fluvastatin

Nthawi zambiri, mankhwala atatu oyamba a statin amagwiritsidwa ntchito: ndi omwe amaphunziridwa kwambiri.

Mlingo wa mankhwala ndi zitsanzo za mapiritsi

Simvastatin ndi mankhwala ofooka kwambiri. Ndizomveka kuzigwiritsa ntchito kwa anthu okhawo omwe cholesterol yawo imachulukirachulukira. Awa ndi mapiritsi monga Zokor, Vasilip, Simvakard, Sivageksal, Simvastol. Amapezeka mu Mlingo wa 10, 20 ndi 40 mg.
Atorvastatin ndi wamphamvu kale. Itha kugwiritsidwa ntchito ngati mulingo wa cholesterol kwambiri. Awa ndi magome ochokera ku cholesterol Liprimar, Atoris, Torvakard, Novostat, Liptonorm. Mlingo ukhoza kukhala 10, 20, 30, 40 ndi 80 mg.
Rosuvostatin ndiye wolimba kwambiri. Madokotala amamulembera cholesterol kwambiri, mukafuna kuchitsitsa. Awa ndi mapiritsi Krestor, Roxer, Mertenil, Rosulip, Tevastor. Rosucard. Ili ndi Mlingo wotsatira: 5, 10, 20 ndi 40 mg.
Lovastatin imapezeka ku Cardiostatin, Choletar, Mevacor. Mankhwalawa ali muyezo wa 20 mg piritsi limodzi.
Fluvastatin pakadali pano ali ndi mtundu umodzi wokha wamapiritsi - awa ndi Lescor (20 kapena 40 mg aliyense)

Monga mukuwonera, mulingo wa mankhwalawa ndiwofanana. Koma chifukwa cha kusiyana pakukhudzika, 10 mg ya rosuvostatin yotsika cholesterol mofulumira kuposa 10 mg ya atorvastatin. Ndipo 10 mg ya Atoris ndiyothandiza kwambiri kuposa 10 mg ya Vasilip. Chifukwa chake, ndi dokotala wokhazikika amene angadziwike ma statin, kuwunika zonse zomwe zimapangitsa, contraindication komanso mwayi wokhala ndi zotsatirapo zoyipa.

Kodi ndingatenge ma statin?

Zanena kale pamwambapa kuti mapiritsi a cholesterol amagwira ntchito m'chiwindi. Chifukwa chake, mankhwalawa ayenera kuganizira matenda a chiwalo ichi.

Simungamwe ma statin ndi:

Matenda a chiwindi mu gawo: pachimake chiwindi, kuchuluka.
Kuchulukitsa ma enzymes ALT ndi ACT mobwerezabwereza katatu.
Kuchulukitsa kuchuluka kwa CPK nthawi zoposa 5.
Mimba, kuyamwa.

Sikoyenera kugwiritsa ntchito ma statins a cholesterol azimayi azaka zosabereka omwe satetezedwa bwino ndikulola kutenga pakati kwakukulu.

Ma Statin amagwiritsidwa ntchito mosamala:

Ndi matenda a chiwindi omwe kale anali.
Ndi mafuta hepatosis ndi kuchuluka pang'ono kwa michere.
Mtundu 2 wa shuga mellitus, wowonongeka pomwe shuga sangasungidwe.
Amuna apakati pa 65 omwe akumamwa mankhwala ambiri kale.

Komabe, mosamala - sizitanthauza kuti sanasankhe.

Kupatula apo, kugwiritsa ntchito ma statins kuchokera ku cholesterol ndikuti amateteza munthu ku matenda monga myocardial infarction, kusokonezeka kwa miyendo (zomwe zingayambitse kumangidwa kwamtima), matenda a sitiroko, matenda a mtima. Izi zoyambitsa tsiku ndi tsiku zimabweretsa kufa kwa anthu masauzande ndipo zimawerengedwa kuti ndi chimodzi mwazomwe zimayambitsa imfa. Koma chiopsezo chofa ndi mafuta a hepatosis ndi ochepa.

Chifukwa chake, musachite mantha ngati kale mudadwala matenda a chiwindi, ndipo tsopano ma statins adayikidwa. Dokotala azikulangizani kuti mukaayezetseni magazi musanatenge mafuta a cholesterol komanso patatha mwezi umodzi. Ngati mulingo wa ma enzymes a chiwindi uli mu dongosolo, ndiye kuti umagwirizana ndi katunduyo moyenera, ndipo cholesterol imachepa.

Zotsatira zoyipa za ma statins

Kuchokera m'matumbo: m'mimba, mseru, chiwindi, kudzimbidwa.
Kuchokera kwamanjenje: kusowa tulo, kupweteka mutu.

Komabe, zoyipa izi ndizakanthawi ndipo, kuweruza ndi kuwunika kwa anthu, zimatha pambuyo pa masabata awiri ndi atatu ogwiritsa ntchito ma statin.

Vuto lowopsa koma losowa kwambiri ndi rhabdomyolysis. Uku ndiye chiwonongeko cha minofu yawo. Imadziwoneka ngati ululu wamisempha, kutupa, kutulutsa mkodzo. Malinga ndi kafukufuku, milandu ya rhabdomyolysis sikuchitika pafupipafupi: mwa anthu 900,000 omwe adatenga ma statins, anthu 42 okha ndi omwe adawonongeka minofu. Koma ndikukaikira kulikonse, muyenera kulumikizana ndi akatswiri posachedwa.

Kuphatikiza ndi mankhwala ena

Kuvulaza kuchokera ku ma statins kumawonjezera ngati atengedwa nthawi yomweyo monga mankhwala ena: thiazide diaretics (hypothiazide), macrolides (azithromycin), calcium antagonists (amlodipine). Muyenera kupewa kudziyang'anira nokha malamulo a kolesterol - adotolo ayenera kuwunika mankhwala onse omwe munthu amamwa. Adzaona kuti kuphatikiza koteroko ndikotsutsana.

Zomwe muyenera kuwongolera ngati mumamwa ma statins

Pa chithandizo musanayambe, mulingo wa lipids amayeza: cholesterol yathunthu, triglycerides ndi lipids yayitali komanso yotsika. Ngati mulingo wa cholesterol suchepa, ndiye kuti mwina mlingo wake ndi wocheperako. Dokotala angakulangizeni kuti muukulitse kapena dikirani.

Popeza mankhwala omwe amachepetsa cholesterol amakhudza chiwindi, muyenera kupimidwa magazi pafupipafupi kuti muwone kuchuluka kwa ma enzyme. Dokotala wopezeka akuwunika izi.

Asanakhazikitsidwe ma statins: AST, ALT, KFK.
Masabata a 4-6 atayamba kuvomerezedwa: AST, ALT.

Ndi kuwonjezeka kwa muyezo wa AST ndi ALT kuchulukitsa katatu, kuyezetsa magazi kumabwerezedwa. Ngati zotsatira zomwezo zimapezeka pakubwereza magazi mobwerezabwereza, ndiye kuti ma statins amalephera mpaka mulingowo ukhale womwewo. Mwina adokotala angaganize kuti ma statins amatha kusintha ndi mankhwala ena a cholesterol.

Cholesterol ndi chinthu chofunikira m'thupi. Koma ndi kuchuluka kwake, matenda owopsa amatuluka. Sikoyenera kuchita mopepuka kuyezetsa magazi kwa cholesterol yonse. Ngati, malinga ndi zotsatira zake, dokotala akulangizani kuti mutenge ma statins, ndiye kuti ndi ofunikira. Mankhwalawa a cholesterol ali ndi zotsatira zabwino, koma pali zovuta zambiri. Chifukwa chake, ndizoletsedwa kumwa iwo osavomerezeka ndi dokotala.

Kuwongolera ululu

Mavuto opweteka ndi angina pectoris nthawi zambiri amayamba mwadzidzidzi ndipo amakhala pafupifupi mphindi 5. Komabe, ndikofunikira kulingalira kuti pakadali pano ntchito yamtima wasokonezeka kwambiri. Popanda chithandizo chokwanira, izi zimatha kudwala matenda a mtima komanso ngakhale kufa.

Pakakhala vuto la angina pectoris, muyenera kuchita izi:

Lekani kuchita masewera olimbitsa thupi nthawi yomweyo	ululu ukamachitika, muyenera kuyesetsa kuti muchepetse ndi kukhala omasuka, osagona pakadali pano, chifukwa ululu wammbuyo umalimba. ndibwino kuti mukhale pansi ndikutsamira kumbuyo kwa mpando, ngati kuukira kunayamba usiku, tikulimbikitsidwa kuti mukhale pansi.
Ikani piritsi la Nitroglycerin pansi pa lilime	mankhwalawa amathandizira kupumula kwamatumbo, amachepetsa magazi omwe amapita kumtima, Mankhwala amachepetsa katundu pa chiwalo, mutatha kugwiritsa ntchito piritsi limodzi la Nitroglycerin, ndizotheka masekondi 30-60 kuti muchepetse ululu wammbuyo, mutatenga mapiritsi atatu 3 ululu ulibe, muyenera kuyimba ambulansi, motere, pali kuthekera kwakukulu kwa vuto la mtima.
Onani dokotala	ngati vuto la ululu limawoneka ngakhale ndikuchita masewera olimbitsa thupi koyamba kapena kuwukira koyamba, muyenera kufunsa dokotala, mawonetseredwe oterewa akhoza kuwonetsa kukula kwa matenda kapena mawonekedwe a angina osakhazikika.

Nitroglycerin

Nitroglycerin ndiye njira yothandiza kwambiri yochotsera zizindikiro za angina pectoris. Nthawi zambiri, odwala amapatsidwa zakumwa 1% zakumwa zoledzeretsa, madontho atatu omwe amapaka shuga ndikuyika pansi. Ngati mulibe shuga, munthu ayenera kudya nyemba kangapo kuchokera pachidebe cha mankhwala.

Piritsi ingagwiritsidwenso ntchito. Pankhaniyi, mankhwalawa nthawi zambiri amakhala 0,0005 g. Mankhwala ayenera kusungidwa pakamwa, ndikuyalaika pansi pa lilime. Zotsatira zimachitika pambuyo pa mphindi 3-5. Chifukwa cha kugwiritsidwa ntchito koyambirira kwa Nitroglycerin, ndizotheka kuyimitsa msanga kuukira kwa angina pectoris.

Ndi kuyambiranso kwa matendawa, matendawa amatha kugwiritsidwa ntchito mobwerezabwereza popanda zoletsa zazikulu. Osadandaula ndi kugwiritsa ntchito mankhwalawa pafupipafupi kwa zaka zambiri, chifukwa sizowonjezera.

Nthawi zina, kugwiritsa ntchito Nitroglycerin kumadzetsa mavuto. Pakati pawo, ndikofunikira kuwonetsa mutu, chizungulire, nthawi zina - kugunda kwa mtima. Komabe, zizindikirozi zimadutsa mwachangu mokwanira.

Zotsatira zoyipa zambiri zimawoneka mwa anthu omwe ali ndi matenda oopsa. Pankhaniyi, muyenera kumwa mankhwala ochepetsetsa.

Odwala ambiri, Validol amapereka njira yothandizira kwambiri. Nthawi zambiri, madontho 5 a mankhwalawa amaperekedwa. Komanso, mankhwalawa amatha kugwiritsidwa ntchito ngati mapiritsi, omwe ayenera kuyikidwa pansi pa lilime.

Ubwino wa mankhwalawa ndi kusakhalapo kwa zotsatira zoyipa komanso kusokoneza kwenikweni. Validol ilibe mphamvu ngati Nitroglycerin. Chifukwa chake, sizipereka nthawi zonse zotsatira zoyenera ndi kupweteka kwambiri.

Ngati Validol sanayandikire, mutha kugwiritsa ntchito yankho la mowa wa menthol mu ndende ya 3-5%. Ndi anginal phenomenena otsika kwambiri, madontho a Zelenin amaloledwa kugwiritsidwa ntchito.