Malangizo a kumwa Glimecomb ndi analog mankhwala

Kwa zaka zambiri osalimbana ndi ma DIABETES?

Mutu wa Bungwe: “Mudzadabwitsidwa kuti kumakhala kovuta motani kuchiritsa matenda a shuga tsiku lililonse.

Metabolic syndrome, mbali zazikuluzikulu zomwe zimawonetsedwa ngati kunenepa kwambiri, mtundu wachiwiri wa matenda osokoneza bongo ndi matenda oopsa ndi vuto la chitukuko chamakono. Kuchuluka kwa anthu omwe ali m'maiko abwino akudwala matendawa.

• Glucophage wa matenda ashuga a 2
• Mawonekedwe ndi mawonekedwe a mankhwalawa
• Glucophage Kutalika kwa matenda ashuga
• Njira yamachitidwe
• Ndani amene sayenera kumwa mankhwalawa?
• Glucophage ndi ana
• Zotsatira zoyipa Glucophage
• Ndi mankhwala ena ati omwe amakhudza mphamvu ya glucophage?
• Mafunso Ofunsidwa Kawirikawiri
• Siofor kapena Glucophage: ndibwino bwanji kwa matenda ashuga?
• Glucophage kuchokera ku matenda ashuga: ndemanga

Momwe mungadzithandizire nokha kubwezeretsa thupi ndi kugwiritsa ntchito mphamvu zochepa? M'malo mwake, ambiri onenepa kwambiri safuna kuchita nawo masewera ena, ndipo matenda ochititsa chidwi ndi matenda ashuga ndi matenda osapeweka. Makampani opanga mankhwala amapulumutsa.

Malangizo a kumwa Glimecomb ndi analog mankhwala

Pochizira mafupa, owerenga athu adagwiritsa ntchito DiabeNot bwino. Kuwona kutchuka kwa malonda, tidaganiza zoperekera chidwi chanu.

Glimecomb amatanthauza mankhwala omwe amagwiritsidwa ntchito pa matenda a shuga a 2.

Chidacho chili ndi katundu wophatikizidwa wa hypoglycemic.

Mutatha kumwa mankhwalawa, matenda a shuga m'magazi a wodwalayo amadziwika.

Zambiri, kapangidwe ndi mawonekedwe ake amasulidwe

Mankhwala omwe amatchulidwa amachokera ku hypoglycemic wothandizira omwe amamwa pakamwa. Chidacho chimakhala ndi kuphatikiza. Kuphatikiza pa kutsitsa shuga, Glimecomb ili ndi kapamba wambiri. Nthawi zina, mankhwalawa amakhala ndi mphamvu yowonjezera.

Kuphatikizika kwa mankhwalawa kumakhala ndi Metformin hydrochloride mu 500 mg ndi Gliclazide - 40 mg, komanso excipients sorbitol ndi croscarmellose sodium. Pochepa, magnesium stearate ndi povidone amapezeka mumankhwala.

Mankhwalawa amapezeka mu mawonekedwe a mapiritsi a cylindrical mumayera oyera, kirimu kapena chikasu. Kwa mapiritsi, kuguba ndi kololedwa. Mapiritsi ali ndi chiopsezo komanso zokongoletsa.

Glimecomb imagulitsidwa pama mapiritsi 10 mumatumba a blister. Paketi imodzi ili ndi 6 mapaketi.

Pharmacology ndi pharmacokinetics

Glimecomb ndi mankhwala osakanikirana omwe amaphatikiza ma hypoglycemic othandizira a gulu la Biguanide ndi zotumphukira za sulfonylurea.

Wothandizirayo amadziwika ndi zotsatira za pancreatic ndi extrapancreatic.

Gliclazide ndi imodzi mwazinthu zazikulu zamankhwala. Ndiwochokera ku sulfonylurea.

• yogwira insulin
• kutsika kwa shuga m'magazi,
• kutsitsa kupindika kwamapewa
• Matenda a mtima kukhathamiritsa.

Gliclazide linalake ndipo tikulephera kupezeka kwa microthrombosis. Nthawi yayitali kugwiritsa ntchito mankhwalawa odwala matenda ashuga nephropathy, kuchepa kwa proteinuria (kukhalapo kwa mapuloteni mu mkodzo).

Gliclazide imakhudza kulemera kwa wodwala yemwe amamwa mankhwalawo. Ndi zakudya zoyenera odwala omwe ali ndi matenda osokoneza bongo omwe amatenga Glimecomb, kuwonda kumadziwika.

Metformin, yomwe ndi gawo la mankhwalawo, amatanthauza gulu lalikulu. Vutoli limachepetsa kuchuluka kwa shuga m'magazi, limathandizira kufooketsa njira yopopera shuga m'mimba ndi matumbo. Metformin imathandizira kufulumizitsa njira yogwiritsira ntchito glucose kuchokera ku minofu ya thupi.

Mankhwala amachepetsa cholesterol, otsika kachulukidwe lipoproteins. Potere, Metformin sikukhudza kuchuluka kwa lipoproteins a kachulukidwe kosiyanasiyana. Monga Gliclazide, amachepetsa kulemera kwa wodwalayo. Zilibe mphamvu pakakhala insulin m'magazi. Zilibe kuthandiza kuti mawonekedwe a hypoglycemic asinthe. Gliclazide ndi metformin amazisamalira mosiyanasiyana kwa wodwala. Gliclazide imadziwika ndi mayamwidwe apamwamba kuposa a Metformin.

Mulingo wokulirapo wa Gliclazide m'magazi umafikiridwa patatha maola atatu kuchokera nthawi yomwe munayamba kumwa mankhwalawo. Thupi limachotsedwa kudzera mu impso (70%) ndi matumbo (12%). Kutha kwa theka moyo kumafika maola 20.

The bioavailability wa Metformin ndi 60%. Thupi limadziunjikira m'magazi ofiira. Hafu ya moyo ndi maola 6. Kuchoka m'thupi kumachitika kudzera mu impso, komanso matumbo (30%).

Zizindikiro ndi contraindication

Mankhwalawa amalimbikitsidwa kwa odwala matenda ashuga omwe ali ndi matenda a shuga 2 ngati:

• chithandizo cham'mbuyomu limodzi ndi zakudya komanso masewera olimbitsa thupi sizinachite bwino,
• pakufunika kubwezeretsa mankhwala omwe amaphatikizidwa kale pogwiritsa ntchito Gliclazide ndi Metformin mwa odwala omwe ali ndi shuga m'magazi.

Mankhwalawa amadziwika ndi mndandanda wambiri wa zotsutsana, zomwe:

• kupezeka kwa matenda a shuga 1
• tsankho lanu pazigawo za mankhwala,
• kuphwanya impso ntchito,
• mimba
• kulephera kwa chiwindi
• lactic acidosis,
• kulephera kwa mtima
• wodwala matenda ashuga
• kuyamwa
• matenda osiyanasiyana
• myocardial infaration
• matenda a porphyrin
• matenda a shuga
• opaleshoni yapitayi
• Nthawi yopanga maphunziro a x-ray ndikulemba mayeso pogwiritsa ntchito ma radioisotope poyambitsa ma cell osiyanitsa ndi ayodini mthupi (ndizoletsedwa kutenga masiku awiri isanachitike komanso pambuyo pa izi),
• kuvulala kwambiri
• Mankhwala okhudzana ndi matenda a mtima ndi impso,
• kulephera kupuma
• kuledzera
• shuga wamagazi ochepa (hypoglycemia),
• matenda oopsa a impso
• uchidakwa wambiri,
• kupsa kwambiri thupi,
• Kutsatira odwala omwe ali ndi hypocaloric zakudya,
• kutenga miconazole,
• matenda ashuga ketoacidosis.

Malangizo ogwiritsira ntchito ndi malangizo apadera

Mlingo wa mankhwalawa ndiwothandiza kwa wodwala aliyense. Ndikulimbikitsidwa kumwa mapiritsi atatu patsiku. M'masiku otsatirawo amathandizira, kuwonjezereka kwa mlingo kumatha, kutengera zomwe zimawonetsa shuga m'magazi a wodwala komanso kuchuluka kwa matenda ake. Kwa Glimecomb, mlingo waukulu ndi mapiritsi 5 patsiku.

Mankhwala tikulimbikitsidwa kuti kumwedwa m'mawa ndi madzulo. Mankhwalawa amatengedwa nthawi yakudya kapena itatha.

Chipangizocho sichikulimbikitsidwa kwa odwala azaka zopitilira 60, ogwira ntchito movutikira. Pogwira ntchito molimbika komanso kutenga Glimecomb mwa okalamba, lactic acidosis imatha kukula.

Mimba ndi imodzi mwazomwe zimayambitsa kumwa mankhwalawa. Mimba ikachitika, komanso musanakonzekere, ndikofunikira kusintha mankhwalawa ndi insulin.

Kuyamwitsa kumapangitsanso chifukwa choponderezedwa pazinthu zambiri za mankhwala mkaka wamawere. Ndikofunika kusiya kudyetsa kwa nthawi yayitali kumwa Glimecomb ndi amayi kapena kusiya kumwa mankhwalawo pakupatsa msambo.

Mosamala, ndikofunikira kumwa mankhwalawa kwa odwala omwe ali ndi:

• malungo
• mavuto a chithokomiro
• adrenal kusowa.

Mankhwalawa amaletsedwa kwa odwala omwe ali ndi matenda a chiwindi, komanso kuwonongeka kwaimpso, limodzi ndi mantha, kufooka kwa thupi, ndi zina zovuta.

Mankhwalawa amatengedwa pokhapokha ngati odwala azitsatira zakudya zama calori zochepa ndi kudya pang'ono mafuta. M'masiku oyambirira a chithandizo, kuwongolera shuga kumafunikanso. Mankhwala omwe mumalandira ndi mankhwalawa amachitika kokha mwa odwala omwe amalandila zakudya zonse.

Sulfonylureas, yomwe ndi gawo la mankhwalawa, imatha kupangitsa hypoglycemia. Imachitika ndi otsika kalori zakudya ndi zolimbitsa thupi. Ndikofunikira nthawi zonse kusintha mtundu wa mankhwalawa, makamaka odwala okalamba.

Hypoglycemia imatha kudwala odwala akamatenga:

• mowa wa ethyl
• mankhwala osapweteka a antiidal.

Kusala kudya kumathandizanso kukhala ndi vuto la hypoglycemia mwa odwala, ndipo mankhwala osokoneza bongo monga reserpine omwe amakhala ndi clonidine amawaphimba.

Milandu yomwe odwala amachitidwa opaleshoni, ngati atentha, kuvulala, matenda a malungo, komanso myalgia, lactic acidosis, kusiya kwa mankhwalawo kumafunika.

Mankhwalawa angakhudze kuyendetsa. Chisamaliro chiyenera kutengedwa.

Amayenera kusiya kumwa Glimecomb masiku awiri asanafike komanso atalowa m'thupi la wodwalayo wothandizira wa radiopaque ndi ayodini.

Zotsatira zoyipa ndi bongo

Mwa zina zoyipa zomwe zimachitika chifukwa chogwiritsa ntchito mankhwalawa ndizotheka:

• hypoglycemia ndi thukuta kwambiri, kufooka, chizungulire, njala ndi kukomoka,
• lactic acidosis ndi kugona, kutsika magazi, kufooka, kupweteka kwam'mimba, myalgia,
• nseru
• kuchepa magazi
• mavuto amawonedwe
• urticaria
• mziwindi vasculitis,
• kutsegula m'mimba
• kuyabwa
• hemolytic anemia,
• kuyabwa
• erythropenia
• Nthawi zina, chiwindi,
• kulephera kwa chiwindi.

Zizindikiro zofala kwambiri za bongo ndizo hypoglycemia ndi lactic acidosis. Zizindikiro zonsezi zimafunikira chithandizo kuchipatala. M'njira zonsezi, mankhwalawa amaletsedwa. Poyamba, wodwala amalandila chithandizo, hemodialysis imachitidwa.

Ndi hypoglycemia yofatsa komanso yolimbitsa thupi, ndizokwanira kuti odwala athetse shuga mkati. Woopsa mawonekedwe, shuga amaperekedwa kwa wodwalayo (40%). Njira ina ikhoza kukhala glucagon, yoyendetsedwa yonse ndi minyewa. Kuperekanso chithandizo kumachitika ndi wodwalayo akudya chakudya chopatsa thanzi.

Kuyanjana Ndi Mankhwala Ndi Analogi

Mankhwala amakhudzana ndi mankhwala ena motere:

• kuchuluka kwa hypoglycemic kumalimbikitsidwa akaphatikizidwa ndi enalapril, cimetidine, miconazole, clofibrate, ethionamide, anabolic steroids, cyclophosphamide, tetracycline, reserpine ndi mankhwala ena omwe ali ndi vuto la hypoglycemic,
• amachepetsa hypoglycemic zotsatira atatenga limodzi ndi Clonidine, Phenytoin, Acetazolamide, Furosemide, Danazole, Morphine, Glucagon, Rifampicin, nicotinic acid mu mlingo waukulu, estrogen, mchere wa lithiamu, njira yolerera pakamwa,
• Kugwiritsa ntchito ndi nifedipine kumachepetsa kuchoka kwa metformin,
• Co-makonzedwe ndi cationic wothandizira kumawonjezera kuchuluka kwa metformin m'magazi ndi 60%,
• kumawonjezera ndende ya metformin mgwirizano wa mankhwala ndi furosemide.

Glimecomb ili ndi ma fanizo ndi mawu ofanana:

• Glidiab
• Glyformin
• Glidiab MB
• Kuchulukitsa,
• Metglib
• Fomu,
• Gliclazide MB,
• Diabetesalong
• Gliclazide-Akos.

Piritsi ya kanema ikuwonetsa zizindikiro ndi chithandizo cha matenda ashuga:

Maganizo a akatswiri ndi odwala

Kuchokera pakuwunika kwa odwala, titha kunena kuti Glimecomb amachepetsa shuga m'magazi ndipo amaloledwa bwino, komabe, madokotala amalimbikitsa chisamaliro chake chifukwa cha zovuta zingapo.

Glimecomb ndi chithandizo chothandiza kwa matenda ashuga amtundu wa 2. Koma poganizira zambiri zake, tikulimbikitsidwa kuti ziziwayikidwa mosamala kwa odwala angapo. Makamaka okalamba.

Anna Zheleznova, wazaka 45, endocrinologist

Mankhwala abwino othandizira shuga. Ndidatenga kwa mwezi umodzi, palibe mavuto, ngakhale pali ambiri mwa malangizo. Ndidakondwera ndi mtengo.

Kwa nthawi yayitali ndakhala ndikudwala matenda a shuga. Ndimalola Glimecomb. Mankhwalawa ndiabwino komanso osakwera mtengo kwambiri. Amachepetsa shuga bwino. Chofunikira ndi kudya bwino komanso kudya moyenera.

Pochizira mafupa, owerenga athu adagwiritsa ntchito DiabeNot bwino. Kuwona kutchuka kwa malonda, tidaganiza zoperekera chidwi chanu.

Mankhwala omwe amafotokozedwawu amawagawa pogwiritsa ntchito mankhwala. Mtengo wake umachokera ku ma ruble 440-580. Mtengo wa anzanu ena apabanja umachokera ku 82 mpaka 423 rubles.

Momwe mungagwiritsire ntchito mapiritsi a Amaryl ndi momwe angasinthidwire

Amaril amadziwika kuti ndiodziwika bwino pakati pa odwala matenda ashuga. Kulandila kwake kumalola odwala kuwongolera momwe alili, kuchepetsa mwayi wokhala ndi hyperglycemia. Mankhwala okhawo amalembera anthu okhawo omwe ali ndi matenda a shuga a II.

Zomwe zimagwira ku Amaril ndi glimepiride. Zomwe mapiritsiwo amaphatikizidwira ndizothandiza. Mndandanda wawo udzadalira mlingo wa glimepiride. Kuphatikiza kosiyana kwa zinthu zowonjezera pamapiritsi ndi chifukwa cha mtundu wina.

INN (dzina lapadziko lonse): glimepiride (Latin Glimepiride).

Amalil M1, M2 amagulitsanso malo ogulitsa mankhwala. Kuphatikiza pa glimepiride, kapangidwe ka mapiritsiwa kumaphatikiza metformin mu 250 kapena 500 mg, motsatana. Mankhwala osakanikirana awa amatha kupatsidwa ndi endocrinologist wokha.

Kutulutsa Fomu

Amaryl akugulitsa mawonekedwe piritsi. Mtundu umatengera mlingo wa zomwe zimagwiritsidwa ntchito:

• 1 mg glimepiride - pinki,
• 2 - zobiriwira
• 3 - chikasu chopepuka
• 4- buluu.

Amasiyana mu zolemba zomwe zimagwiritsidwa ntchito pamapiritsi.

Zotsatira za pharmacological

Glimepiride imakhala ndi mphamvu pa thupi. Ndi yotengedwa m'badwo wachitatu sulfonylurea.

Amaryl ali ndi mphamvu yayitali. Mapiritsi akagwiritsidwa ntchito, kapamba amayambitsidwa, ndipo ma cell a beta amayambitsa. Zotsatira zake, insulin imayamba kumasulidwa kwa iwo, mahomoni amalowa m'magazi. Izi zimathandizira kuchepetsa kuchuluka kwa shuga mutatha kudya.

Nthawi yomweyo, glimepiride imakhala ndi extrapancreatic. Zimawonjezera kukhudzika kwa minofu, minofu yamafuta ku insulin. Mukamagwiritsa ntchito mankhwala, antioxidant, antiatherogenic, antiplatelet zotsatira zimawonedwa.

Amaril amasiyana ndi ena omwe amapezeka m'magulu ena a sulfonylurea chifukwa chakuti akagwiritsidwa ntchito, zomwe zimapezeka mu insulini ndizotsika kuposa momwe mumagwiritsira ntchito mankhwala ena a hypoglycemic. Chifukwa cha izi, chiopsezo cha hypoglycemia ndichochepa.

Kulimbikitsa njira yogwiritsira ntchito glucose mu minofu ndi mafuta minofu imakhala yotheka chifukwa cha kupezeka kwa mapuloteni apadera azotengera mumitsempha yama cell. Amaryl amalimbikitsa zochitika zawo.

Mankhwalawa sichiletsa njira za ATP zotsekera mtima za mtima. Akadali ndi mwayi kuzolowera nyengo ya ischemic.

Chithandizo cha Amaryl chimalepheretsa kupanga shuga m'magazi a chiwindi. Kuwonetsa kumeneku kumachitika chifukwa cha kuchuluka kwa fructose-2,6-biophosphate mu hepatocytes. Izi zimayimitsa gluconeogeneis.

Mankhwalawa amathandiza kutsekereza katulutsidwe wa cycloo oxygenase, kuchepetsa kusintha kwa kusintha kwa thromboxane A2 kuchokera ku arachidonic acid. Chifukwa cha izi, kuchuluka kwa kuphatikiza kwa mapulateleti kumachepa. Mothandizidwa ndi Amaril, kuwonongeka kwa ma oxidative reaction, omwe amawonedwa m'matenda osagwirizana ndi insulin, amachepetsa.

Lemberani mankhwala potengera glimepiride kwa odwala omwe ali ndi matenda amtundu II, ngati zolimbitsa thupi, kudya sikumakulolani kuwongolera shuga.

Malangizo ogwiritsira ntchito akuwonetsa kuti amaloledwa kuphatikiza Amaril ndi jekeseni wa metformin, insulin.

Dr. Bernstein akuumiriza kuti kusankhidwa kwa ma hypoglycemic othandizira sikuli kolondola, ngakhale pali zambiri zomwe zingagwiritsidwe ntchito. Amatinso kuti mankhwalawa ndi owopsa, amalimbikitsa zovuta za metabolic. Kuthetsa matendawa, simungagwiritse ntchito mankhwala ochokera ku sulfonylurea, koma zakudya zomwe zimaphatikizidwa ndi mtundu wina wa mankhwala.

Contraindication

Amaril sayenera kutumizidwa kwa odwala omwe:

• kudalira insulini
• ketoacidosis, matenda ashuga,
• Impso imagwidwa bwino (kuphatikizapo vuto la hemodialysis),
• Kugwiritsa ntchito bwino kwa chiwindi,
• kusalolera kapena hypersensitivity glimepiride, othamangitsa, mankhwala ena a gulu la sulfonylurea,
• zaka za ana.

Madokotala sayenera kupereka mankhwalawa kwa odwala omwe ali ndi vuto la kudya, kudya mosasamala, kuchepetsa calorie, kudya osakwana 1000 kcal. Contraindication ndikuphwanya njira ya mayamwidwe a chakudya kuchokera m'mimba thirakiti.

Mawonekedwe ndi mawonekedwe a mankhwalawa

Metformin hydrochloride imawerengedwa kuti ndiyo chinthu chofunikira kwambiri pa mankhwalawa. Monga zina zowonjezera ndi:

• magnesium wakuba,
• povidone
• michere ya microcrystalline
• hypromellose (2820 ndi 2356).

Wothandizila othandizira amapezeka mu mawonekedwe a mapiritsi, mapiritsi okhala ndi Mlingo wa chinthu chachikulu chomwe amapezeka mu 500, 850 ndi 1000 mg. Mapiritsi a shuga a Biconvex Glucophage ndiwopanda tanthauzo.

Adakutidwa ndi utoto wotetemera. Kumbali ziwiri, zoopsa zapadera zimayikidwa piritsi, pa imodzi mwa izo ndikuwonetsedwa.

Zotsatira zoyipa

Musanayambe kumwa Amaril, muyenera kuzolowera zonunkhira zamankhwala. Odwala ayenera kudziwa zomwe zimachitika.

Zotsatira zoyipa kwambiri zimaphatikizapo matenda a metabolic. Wodwala amatha kuyamba kukhala ndi hypoglycemia atangomaliza kumwa mapiritsi. Kunyumba, izi sizovuta kutengera, mudzafunika thandizo la madokotala. Koma kuchepa kwadzidzidzi kwa shuga m'magazi kumawonedwa kawirikawiri, osati kangapo poyerekeza ndi mwa 1 wodwala mwa 1000.

Mukamatenga Amaril, palinso zovuta kuchokera ku:

• Matumbo am'mimba: kutsekula m'mimba, njala, kupweteka kwa epigastrium, jaundice, nseru, hepatitis, kukula kwa chiwindi,
• ziwalo za hematopoietic: thrombocytopenia, agranulocytosis, erythrocytopenia, leukopenia,
• dongosolo lamanjenje: kuwodzera kowonjezereka, kutopa, kupweteka mutu, nkhawa zowonjezereka, kukwiya, kusokonezeka kwa mawu, chisokonezo, paresis, kukokana kwa ubongo, mawonekedwe a thukuta lomata kwambiri.
• ziwalo zamawonedwe: kusokonezeka kwakanthawi chifukwa cha kusintha kwa shuga m'magazi.

Ena amakhala ndi zotulukapo zamagetsi. Odwala amadandaula za kuyabwa, mawonekedwe a zotupa pakhungu, urticaria, matupi awo saviyo. Nthawi zambiri, zotsatirazi zimakhala zofatsa, nthawi zina, mwina anthu sangadabwe chifukwa cha mantha.

Bongo

Amaryl iyenera kudyedwa ndi kuchuluka kwa madokotala. Mankhwala osokoneza bongo amakhala chifukwa cha hypoglycemia. Kuchepetsa kwambiri shuga nthawi zina kumakhumudwitsa wodwala matenda ashuga.

Ngati kudya kwakololedwa kwatha, nseru, kusanza, kupweteka kwa epigastric kumawonekera. Zotsatira zoyipa zingapo zimatha kuchitika:

• kuwonongeka kwamawonekedwe
• kugona
• kunjenjemera
• kukokana
• chikomokere
• zovuta zamgwirizano.

Pankhani ya bongo, ndikofunikira kuti muzitsuka m'mimba. Pambuyo pakuyeretsa perekani ma enterosorbents. Nthawi yomweyo, njira yothetsera shuga imayendetsedwa kudzera m'mitsempha. Maluso ena ochitapo kanthu amakulitsidwa kutengera mkhalidwe wa wodwalayo. Wodwala, wodwala amagonekedwa m'chipinda chodyeramo odwala kwambiri.

Kuchita

Asanapereke mankhwala Amaryl, dokotala ayenera kudziwa kuti ndi mankhwala ati omwe wodwala amamwa. Mankhwala ena amalimbikitsa, ena amachepetsa hypoglycemic zotsatira za glimepiride.

Mukamachititsa maphunziro, zidapezeka kuti kuchepa kwakukulu kwa shuga m'magazi kumawonedwa mukamadyedwa:

• othandizirana pakamwa
• Phenylbutazone
• Oxyphenbutazone,
• Azapropasone
• Sulfinpyrazone,
• Metformin
• Tetracycline
• Miconazole
• salicylates,
• Mao zoletsa
• mahomoni ogonana amuna
• anabolic steroids
• mankhwala a quinol,
• Clarithromycin
• Fluconazole
• omvera,
• mafupa.

Chifukwa chake, sikulimbikitsidwa kuti muyambe kumwa Amaryl nokha popanda kulandira mankhwala kuchokera kwa dokotala.

Otsatirawa amachepetsa mphamvu ya glimepiride:

• progestogens
• estrogens
• thiazide okodzeya,
• saluretics
• glucocorticoids,
• nicotinic acid (mukamagwiritsa ntchito muyezo waukulu),
• mankhwala othandizira (operekedwa nthawi yayitali),
• barbiturates
• Rifampicin,
• Glucagon.

Zoterezi ziyenera kukumbukiridwa posankha mlingo.

Sympatolytics (beta-blockers, reserpine, clonidine, guanethidine) ali ndi zotsatira zosayembekezereka pa hypoglycemic zotsatira za Amaril.

Mukamagwiritsa ntchito zomwe zimachokera ku coumarin, dziwani kuti: glimepiride imakulitsa kapena kufooketsa mphamvu ya mankhwalawa pathupi.

Dotolo amasankha mankhwala osokoneza bongo, mankhwala osokoneza bongo a anti-yotupa, komanso mankhwala ena otchuka.

Amaryl imaphatikizidwa ndi insulin, metformin. Kuphatikiza uku kumafunikira pamene mukutenga glimepiride sikutheka kukwaniritsa kufunika kwa metabolic. Mlingo wa mankhwala uliwonse umayikidwa ndi dokotala payekhapayekha.

Nthawi zina, madokotala amalimbikitsa kumwa Yanumet ndi Amaril nthawi yomweyo. Ndi mankhwalawa, wodwala amalandira:

Kuphatikiza kwapadera kwa zosakaniza zomwe zingagwire bwino ntchito kumathandizanso kuthandizira, kumathandizira kuwongolera momwe anthu odwala matenda ashuga angathere.

Tsiku lotha ntchito

Gwiritsani ntchito mankhwalawa ndikuloledwa kwa miyezi 36 kuyambira tsiku lotulutsidwa.

Woyenerera endocrinologist ayenera kusankha cholowa m'malo cha Amaryl. Amatha kukupatsirani analogi yopangidwa pamaziko a chinthu chomwechi, kapena asankhe mankhwala opangidwa kuchokera ku zinthu zina.

Odwala amatha kupatsidwa mwayi wogwirizira Russian, Diamerid, wotsika mtengo. Mapiritsi 30 a mankhwalawa, opangidwa pamaziko a glimepiride, ndi mlingo wa 1 mg mu mankhwala, odwala amalipira 179 p. Ndi kukakamizidwa kwa ndende yogwira ntchito, mtengo umakwezeka. Kwa diamerid mu gawo la 4 mg, 383 p.

Ngati ndi kotheka, sinthani Amaryl ndi mankhwala a Glimepiride, omwe amapangidwa ndi kampani yaku Russia Vertex. Mapiritsi osonyezedwawo ndiokwera mtengo. Phukusi la ma PC 30. 2 mg iyenera kulipira 191 p.

Mtengo wa Glimepiride Canon, womwe umapangidwa ndi Canonfarm, ndi wotsika kwambiri. Mtengo wa phukusi la mapiritsi 30 a 2 mg amadziwika kuti ndi wotsika mtengo, ndi 154 p.

Ngati glimepiride ndi yolekerera, odwala amapatsidwa ma analogi ena omwe amapangidwa pamaziko a metformin (Avandamet, Glimecomb, Metglib) kapena vildagliptin (Galvus). Amasankhidwa poganizira zomwe zimachitika m'thupi la wodwalayo.

Mowa ndi Amaryl

Sizingatheke kuneneratu pasadakhale momwe zakumwa zakumwa zoledzeretsa zimakhudzira munthu yemwe amamwa mankhwala osokoneza bongo a glimepiride. Mowa umatha kufooketsa kapena kuwonjezera mphamvu ya hypoglycemic ya Amaril. Chifukwa chake, sizingathe kuwonongedwa nthawi yomweyo.

Mankhwala a Hypoglycemic ayenera kumwa kwa nthawi yayitali. Chifukwa cha izi, kuletsa kwakumwa pakumwa zakumwa zoledzeretsa kwa ambiri kumakhala vuto.

Mimba, kuyamwa

Munthawi yamatumbo a mwana, kuyamwitsa wakhanda, zotumphukira za sulfonylurea sizingagwiritsidwe ntchito. M'magazi a mayi woyembekezera, kuchuluka kwa glucose kuyenera kukhala kosadutsa malire. Kupatula apo, hyperglycemia imabweretsa chiwopsezo cha kubadwa mwatsopano, kumawonjezera kufa kwa ana.

Amayi oyembekezera amapititsidwa ku insulin. Ndikotheka kupatula kuthekera kwa poizoni wamavuto osokoneza bongo kwa mwana mu utero ngati mutasiya sulfonylurea pa gawo lokonzekera kutenga pakati.

Pa mkaka wa m`mawere, mankhwala a Amaril saloledwa. Zinthu zodutsa zimapita mkaka wa m'mawere, thupi la wakhanda. Mukamayamwitsa, ndikofunikira kuti mayiyu asinthe mankhwala a insulin.

Kwa odwala ambiri, malingaliro a chithandizo cha endocrinologist sikokwanira kuti ayambe kumwa mankhwala atsopano. Madokotala amati mapiritsi amathandizira kapamba kuti apange insulin, pomwe akuwonjezera chidwi cha minofu kwa icho. Izi zimathandizira kuti glucose ayambe kulowa mu thupi.

Koma odwala akufuna kumva lingaliro la mankhwalawo kuchokera kwa odwala matenda ashuga ena. Kufunitsitsa kudziwa kuwunika kwa odwala ena kumachitika chifukwa cha kukwera mtengo kwa mankhwalawa. Kupatula apo, pali mitundu yambiri yamankhwala ogulitsa omwe amapangidwa kuti achepetse shuga, mtengo wake umatsika kwambiri.

Mukamatenga Amaril kwa zaka 1-2, palibe zoyipa zomwe zimawonedwa. Kuchita kumawonetsa kuti ochepa amakumana ndi zovuta akamagwiritsa ntchito mankhwalawa. Nthawi zambiri, mavuto amayamba Amaril M akagwiritsidwa ntchito ngati mankhwala, omwe kuwonjezera pa glimepiride amaphatikizanso metformin. Odwala amadandaula chifukwa cha kuzizira thupi, kuyabwa pakhungu, kukula kwa matenda oopsa. Atatha kumwa mapiritsiwa, anthu ena amamva vuto la hypoglycemic likuyandikira, ngakhale mukamayang'ana zimapezeka kuti kuchepa kwa kuchuluka kwa glucose sikofunikira.

M'miyezi yoyambirira yogwiritsa ntchito, glimepiride amakonzekera bwino shuga. Koma madokotala ena amawona kuti mphamvu ya mankhwalawo imayamba kuwonongeka pakapita nthawi. Wodwalayo amawonjezera kuchuluka kwa mankhwalawa, kenako amaphatikiza mankhwala. Pokhapokha mwa njira imeneyi ndizotheka kukwaniritsa kusintha kwakanthawi kwa boma. Koma chifukwa chakuchepa kwa mphamvu ya mankhwalawa, wodwalayo amapitilira shuga mthupi. Izi zimabweretsa kuwonongeka kwapang'onopang'ono.

Mothandizidwa ndi Amaril, odwala matenda ashuga atha kusintha pang'ono pang'onopang'ono kufunika koti apange jakisoni wokhazikika wa insulin. Ngakhale kumayambiriro kwa chithandizo, ambiri ali ndi zizindikiro za hypoglycemia. Odwala amadandaula chifukwa cha mseru, manja akunjenjemera, chizungulire, kumangokhala ndi njala. Pang'onopang'ono, vutolo limayenda bwino, mawonekedwe owoneka amachoka.

Mtengo, kuti mugule

Mapiritsi a Amaryl amagulitsidwa pafupifupi mankhwala onse. Mtengo wa phukusi la zidutswa 30 mwachindunji zimatengera mulingo womwe dokotala walimbikitsa.

Mapaketi a mapiritsi 90 akugulitsidwa. Ngati mumagula Amaril phukusi loterolo, mudzapulumutsa pang'ono. Pozaza matenti 90 (2 mg) muyenera kulipira 1728 p.

Anthu odwala matenda ashuga amalangizidwanso kuti aziyang'anira mitengo m'masitolo osiyanasiyana. Amaryl nthawi zina amagulitsidwa pamtengo.

Glucophage Kutalika kwa matenda ashuga

Glucophage Long ndi metformin yothandiza makamaka chifukwa cha zotsatira zake zanthawi yayitali.

Njira yapadera yothandizira mankhwalawa imapangitsa kuti zitheke kukwaniritsa zofananazo ngati mukugwiritsa ntchito metformin wamba, komabe, zotsatira zake zimapitiliza kwa nthawi yayitali, chifukwa chake, nthawi zambiri zimakhala zokwanira kugwiritsa ntchito Glucophage Long kamodzi patsiku.

Izi zimathandizira kwambiri kulolerana kwa mankhwalawo komanso moyo wa odwala.

Kukula kwapadera komwe kumagwiritsidwa ntchito popanga mapiritsi kumalola chinthu chogwira ntchito kuti chitha kulowa mu lumen yamtumbo motsatana komanso mofanananira, chifukwa chomwe glucose yolondola imasungidwa nthawi yonseyo, popanda kulumpha kapena madontho.

Kunja, piritsi imakutidwa ndi filimu yosungunula pang'onopang'ono, mkati mwake ndiye maziko okhala ndi zinthu za metformin. Pamene nembanemba imasungunuka pang'onopang'ono, chinthucho chimatuluka. Nthawi yomweyo, kupindika kwamatumbo ndi acidity sikumapangitsa zambiri pakumasulidwa kwa metformin; motere, zotsatira zabwino zimapezeka mwa odwala osiyanasiyana.

Gwiritsani ntchito Glucofage Nthawi imodzi. Izi zimachotsa kusakhudzidwa komwe kumachitika m'matumbo am'mimba, omwe amachitika pakudya metformin, polumikizana ndi kuchuluka kwake kwakhungu m'magazi.

Njira yamachitidwe

Mankhwala ndi a gulu la Biguanides ndipo amapangidwa kuti achepetse magazi. Mfundo za glucophage ndikuti, pakuchepetsa kwambiri shuga, sizimabweretsa vuto la hypoglycemic.

Kuphatikiza apo, sizimawonjezera kupanga insulin ndipo sizimakhudza kuchuluka kwa glucose mwa anthu athanzi. The peculiarity of the mechanism of glucophage based on the chakuti imathandizira chidwi cha zolandilira ku insulin ndikuyambitsa kukonzanso kwa shuga ndi minyewa ya minofu.

Amachepetsa njira yodzikundikira glucose m'chiwindi, komanso chimbudzi cha chakudya ndi chimbudzi. Imachita bwino kwambiri kagayidwe kamafuta: imachepetsa kuchuluka kwa cholesterol, triglycerides ndi lipoproteins yotsika.

The bioavailability wa malonda si ochepera 60%. Imafikiridwa mwachangu kudzera m'makoma am'mimba ndipo kuchuluka kwakukulu kwa zinthu zomwe zili m'magazi kumalowanso maola awiri ndi theka pambuyo pakamwa.

Chinthu chogwira ntchito sichikhudza mapuloteni am magazi ndipo chimafalikira mwachangu kuma cell a thupi. Simalinganizidwa ndi chiwindi ndipo amachotsa mkodzo. Pali chiopsezo chopinga cha mankhwala mu minyewa mwa anthu omwe ali ndi vuto laimpso.

Ndani amene sayenera kumwa mankhwalawa?

Odwala ena omwe akutenga Glucofage amadwala matenda oopsa - lactic acidosis. Izi zimachitika chifukwa cha kudzikundikira kwa lactic acid m'magazi ndipo nthawi zambiri zimachitika ndi anthu omwe ali ndi vuto la impso.

Anthu ambiri omwe ali ndi matenda amtunduwu, madokotala samapereka mankhwala. Kuphatikiza apo, pali zinthu zina zomwe zingakulitse mwayi wopeza lactic acidosis.

Izi zimagwira ntchito kwa odwala omwe:

• mavuto a chiwindi
• kulephera kwa mtima
• pali mankhwala osagwirizana,
• mimba kapena mkaka wa m'mimba,
• opaleshoni idakonzedwa posachedwa.

Ndi mankhwala ena ati omwe amakhudza mphamvu ya glucophage?

Lankhulani ndi dokotala wanu za kumwa mankhwalawa nthawi yomweyo monga glucophage.

Sitikulimbikitsidwa kuphatikiza mankhwalawa ndi:

Kugwiritsira ntchito kwina kwa mankhwalawa ndi glucophage kungayambitse matenda a shuga (hypoglycemia), omwe ndi:

• phenytoin
• mapiritsi othandizira kubereka kapena mankhwala olowa m'mimba,
• zakudya zam'mapiritsi kapena mankhwala a mphumu, chimfine kapena chifuwa,
• mapiritsi a diuretic
• mtima kapena mankhwala oopsa,
• niacin (Advicor, Niaspan, Niacor, Simcor, Srb-niacin, etc.),
• phenothiazines (Compazin et al.),
• mankhwala a steroid (prednisone, dexamethasone ndi ena),
• mankhwala a mahomoni a chithokomiro cha chithokomiro (Synthroid ndi ena).

Mndandandawu suti wathunthu. Mankhwala ena amatha kuwonjezera kapena kuchepetsa mphamvu ya glucophage pakuchepetsa shuga.

Mafunso Ofunsidwa Kawirikawiri

1. Chimachitika ndi chiani ndikaphonya mlingo?

Imwani mankhwala omwe mwasowa mukangokumbukira (onetsetsani kuti mumwa mankhwalawo ndi chakudya). Lumikizani mlingo womwe mwasowa ngati nthawi yotsiriza yomwe mwakonzekererayi ndiyifupi. Sikulimbikitsidwa kumwa mankhwala ena owonjezereka kuti mupange mlingo womwe mwasowa.

1. Chimachitika ndi chiyani ngati mumagwiritsa ntchito bongo mopitirira malire?

Mankhwala osokoneza bongo a metformin angayambitse kukula kwa lactic acidosis, yomwe ikhoza kupha.

1. Ndiyenera kupewa chiyani ndikamamwa glucophage?

Pewani kumwa mowa. Imachepetsa shuga m'magazi ndipo imatha kukulitsa chiopsezo cha lactic acidosis mukamatenga Glucofage.

Glucophage kuchokera ku matenda ashuga: ndemanga

Kupanga chithunzithunzi chazomwe chimayambira matenda a shuga motsogozedwa ndi glucophage, kafukufuku adachitika pakati pa odwala. Kuti muchepetse zotsatira, ndemanga zidagawika m'magulu atatu ndipo cholinga chachikulu chidasankhidwa:

Ndidapita kwa dotolo ndili ndi vuto loti ndizichedwa kulemera msanga ngakhale kuti ndimadya komanso ndimachita masewera olimbitsa thupi, nditapimidwa kuchipatala ndidapezeka kuti ndili ndi insulin kwambiri komanso hypothyroidism, yomwe idapangitsa vuto la kulemera. Dokotala wanga anandiuza kuti ndimwe manformin pa mlingo waukulu wa 850 mg katatu pa tsiku ndikuyamba kulandira mankhwala a chithokomiro. Pakupita miyezi itatu, kulemera kunapangitsa kuti insulin ipangidwe. Ndinkakonzekera kutenga Glucofage kwa moyo wanga wonse.

Kutsiliza: kugwiritsa ntchito glucophage pafupipafupi kumapereka zotsatira zabwino ndi kuchepa kwakukulu.

Glucophage amatengedwa kawiri patsiku ndi mkazi wake. Ndasowa kangapo. Ndinachepetsa magazi anga pang'ono, koma mavuto ake anali oopsa. Chepetsani mlingo wa metformin. Pamodzi ndi zakudya komanso masewera olimbitsa thupi, mankhwalawa adachepetsa shuga m'magazi, ndinganene, 20%.

Kutsiliza: Kuthamangathira mankhwala kumayambitsa mavuto.

Woikidwa pafupi mwezi wapitawu, wapezeka posachedwapa ndi matenda a shuga a 2. Adatenga sabata zitatu. Zotsatira zoyipa sizinali zofooka poyamba, koma zidakulirakulira mpaka ndidakagonekera kuchipatala. Inayimitsidwa kutenga masiku awiri apitawa ndikupezanso mphamvu.

Pochizira mafupa, owerenga athu adagwiritsa ntchito DiabeNot bwino. Kuwona kutchuka kwa malonda, tidaganiza zoperekera chidwi chanu.

Kutsiliza: tsankho la munthu payekha lomwe limagwira