Humalog - malangizo a boma ogwiritsira ntchito

Chiwerengero cha anthu odwala matenda a shuga chikukula chaka chilichonse. Kutsatira zakudya zosamalitsa komanso kugwiritsa ntchito mankhwala osokoneza bongo, pamakhala mwayi wochira kwathunthu ndi mtundu wofatsa wa matendawa.

Ndi matenda a shuga amtundu woyamba, kuchira kwathunthu sikutheka. Kasitomala samatulutsa insulin ya mahomoni, yomwe imakhudzana ndi zochita zonse za metabolic m'ziwalo ndi minofu ya anthu.

Koma mankhwala osankhidwa bwino a insulin amatsata ntchito ya kapamba. Ma mahomoni amtundu wa nthawi yayitali ndi omwe amapatsidwa. Ndi kulumpha lakuthwa mu shuga, ma insulin afupikitsafupi amagwiritsidwa ntchito. Humalog ndi Novorapid ali ndi chochitika chachifupi.

Ubwino ndi zoyipa

Mlingo ndi nthawi ya insulin yochepa imawerengeredwa pasadakhale. Wodwala amayenera kutsatira malangizo omwe ali ndi zopatsa thanzi, kumwa mankhwalawa panthawi. Insulin yochepa imayamba kugwira ntchito pambuyo pa mphindi 30 mpaka 40. Mankhwala a ultrashort amayamba kuchita pakatha mphindi 10-20. Ndi yoyenera milandu ya zakudya zosakonzedwa. Ultrashort insulin yapangidwa kuti ikhale yosavuta m'moyo wa anthu odwala matenda ashuga.

Zoyipa za Humalog ndi Novorapid ndikuti ndizovuta kuwerengetsa kuchuluka kwa chakudya chofunikira chofunikira kupangitsa kuti shuga azikhala mwamphamvu. Mankhwala osokoneza bongo amathamanga. Ngati thupi silinakwanitse kupeza shuga wambiri, hypoglycemia imachitika. Pankhaniyi, kugwiritsa ntchito insulin yochepa ndikudya zakudya zamtundu wamtundu woyenera ndi mtundu wina wa chithandizo.

Ma Ultrashort analogues am'magazi a anthu amapangidwa kuti azikhazikika m'magazi a glucose atatha kudya chakudya champhamvu kwambiri. Koma Humalog ndi Novorapid satha kutengeka ndi thupi mwachangu kuposa dzuwa. Kumwa mankhwalawa sikuletsa chakudya chochepa chamafuta.

Pakudya kwamadzi ochepa, kugwiritsa ntchito insulin yochepa kumaperekedwa. Mankhwala obwezeretsa pakapita nthawi yochepa amafunikira kuti muchepetse shuga mwachangu ndi kulumpha lakuthwa m'magazi a magazi.

Lizpro ndi aspart ndi amphamvu kwambiri kuposa mahomoni osakhalitsa nthawi 1.5-2.5. Mlingo wa mahomoni a ultrashort ndi wotsika poyerekeza ndi insulin yochepa. Mankhwala osokoneza bongo owopsa ndiwotsika kwambiri m'magazi a magazi.

Nthawi zina, odwala matenda ashuga amalimbana ndi mankhwala omwe amangokhala osachita bwino. Timadzi timabowoka thupi thupi lathunthu pambuyo pa maola 1.5. Kugwiritsa ntchito kukonzekera kwa ultrashort kumasonyezedwa kwa odwala oterewa.

Malingaliro a madotolo - ndibwino?

Malinga ndi madokotala, mankhwalawa alibe kusiyana kwakukulu. Koma Novorapid ndi mankhwala okhawo omwe atsimikizira kuti amayi oyembekezera alibe vuto lililonse. Madokotala amakhulupirira kuti Humalog ndiyamphamvu kuposa Novorapid. Humalog imachepetsa kuchuluka kwa shuga kuposa ma 2,5 kuposa mahomoni apfupikidwe a novoropid 1.5 nthawi. Chifukwa chake, mlingo wa mankhwala oyamba umakhala wocheperapo wachiwiri.

Analogue yotchuka kwambiri pochita ndi Apidra. Mankhwalawa ndi wobwerezabwereza wa insulin ya anthu ndipo amagwira mphindi 10 pambuyo pa kutsata. Zomwe zimagwira ndi glulisin.

Zofananira zina:

Chithandizo cha odwala matenda ashuga aliyense amasankhidwa payekha ndi dokotala. Gawo la mitengo ya mankhwala pamlingo womwewo. Malinga ndi odwala, panalibe kusiyana kwakukulu pakusintha kuchokera ku hormone imodzi kupita ku ina. Ma insulin a Ultrashort amaphatikizidwa ndi mahomoni okhala ndi nthawi yayitali. Kutengera ndi zakudya zomwe zalimbikitsidwa, lispro ndi aspart zimasinthidwa ndi mahomoni osakhalitsa.

Malangizo achidule

Malangizo ogwiritsira ntchito insulin Humalog ndiwosakhazikika, ndipo magawo omwe amafotokoza zoyipa ndi mayendedwe akugwiritsidwa ntchito amakhala ndi zigawo zingapo. Kufotokozera kwakutali komwe kumayendera limodzi ndimankhwala ena kumadziwika ndi odwala ngati chenjezo lokhuza kuwopsa kwawo.M'malo mwake, zonse ndizofanana: langizo lalikulu, latsatanetsatane - umboni wa mayesero ambiri kuti mankhwalawa adapirira.

Matenda a shuga ndi kupsinjika kudzakhala chinthu chakale

Matenda a shuga ndi omwe amayambitsa pafupifupi 80% yonse yamikwingwirima ndi kuduladula. Anthu 7 mwa anthu 10 amafa chifukwa cha mitsempha ya mtima kapena ubongo. Pafupifupi nthawi zonse, chifukwa chomaliza chomaliza ndi chimodzimodzi - shuga wamwazi.

Shuga akhoza ndipo amayenera kugwetsedwa, apo ayi. Koma izi sizichiritsa matendawa, koma zimangothandiza kulimbana ndi kufufuza, osati zomwe zimayambitsa matendawa.

Mankhwala okhawo omwe amalimbikitsidwa moyenera pochiza matenda ashuga komanso amagwiritsidwa ntchito ndi ma endocrinologists pantchito yawo ndi awa.

Kugwiritsa ntchito bwino kwa mankhwalawa, kuwerengera malinga ndi njira yokhazikika (kuchuluka kwa odwala omwe achiwonjezere kuchuluka kwa odwala omwe ali pagulu la anthu 100 omwe adachitiridwa chithandizo):

• Matenda a shuga - 95%
• Kuthetsa kwa mitsempha thrombosis - 70%
• Kuthetsa kwa kugunda kwamtima kwamphamvu - 90%
• Kuthana ndi kuthamanga kwa magazi - 92%
• Kulimbitsa tsiku, kukonza kugona usiku - 97%

Opanga si bungwe lazamalonda ndipo amalipidwa ndi chithandizo cha boma. Chifukwa chake, tsopano wokhala aliyense ali ndi mwayi.

Humalogue wavomerezedwa kuti agwiritse ntchito zaka 20 zapitazo, tsopano titha kunena motsimikiza kuti insuliniyi ndiyotetezeka pa mlingo woyenera. Ivomerezedwa kuti imagwiritsidwa ntchito ndi akulu ndi ana, itha kugwiritsidwa ntchito pazochitika zonse, limodzi ndi kusowa kwa mahomoni: mtundu 1 ndi mtundu 2 wa matenda ashuga, opaleshoni ya pancreatic.

Zambiri pa Humalogue:

Zina mwazotsatira zoyipa, hypoglycemia ndi thupi lawo siligwirizana nthawi zambiri zimawonedwa (1-10% ya odwala matenda ashuga). Osakwana 1% odwala amakhala ndi lipodystrophy pamalo opangira jekeseni. Makulidwe azinthu zina zoyipa amakhala ochepera 0.1%.

Chofunika Kwambiri Zokhudza Humalog

Kunyumba, Humalog imayendetsedwa pang'onopang'ono ndi cholembera kapena. Ngati matenda oopsa a hyperglycemia atachotsedwa, mankhwala osokoneza bongo amathandizanso kuchipatala. Pankhaniyi, kuthana ndi shuga pafupipafupi ndikofunikira kupewa bongo.

Chithandizo chogwira ntchito cha mankhwala ndi insulin lispro. Amasiyana ndi mahomoni amunthu pakupanga ma amino acid mu molekyulu. Kusintha koteroko sikulepheretsa ma cell receptors kuzindikira mahomoni, chifukwa chake amapatsira shuga mwa iwo okha. Chiwonetserochi chimakhala ndi ma insulin monomers okha - mamolekyulu osalumikizana. Chifukwa cha izi, imakamizidwa mwachangu komanso moyenera, imayamba kugwira ntchito kuti muchepetse shuga mwachangu kuposa insulin yachilendo.

Humalog ndi mankhwala osokoneza bongo kuposa, mwachitsanzo, kapena. Malinga ndi gulu, amatchulidwa ndi ma insulin omwe ali ndi ultrashort action. Kuyamba kwa ntchito yake kumachitika mwachangu, pafupifupi mphindi 15, kotero odwala matenda ashuga sayenera kudikirira mpaka mankhwalawo atagwira, koma mutha kukonzekera chakudya mukangobaya jakisoni. Chifukwa cha kufupika kwakanthawi, kumakhala kosavuta kukonza zakudya, ndipo chiopsezo cha kuiwala chakudya jakisoni itachepa.

Kuti muthane ndi vuto labwino la glycemic, othandizira othandizira ayenera kuphatikizidwa ndi kuvomerezedwa. Chokha chosiyana ndi kugwiritsa ntchito pampu ya insulin nthawi zonse.

Sankhani

Mlingo wa Humalog umatengera zinthu zambiri ndipo umatsimikiziridwa payekhapayekha kwa aliyense wodwala matenda ashuga. Kugwiritsa ntchito njira zoyenera sikulimbikitsidwa, popeza zimakulitsa kubwezeretsanso shuga. Ngati wodwala amatsatira zakudya zamafuta ochepa, mlingo wa Humalog umakhala wocheperako kuposa momwe oyang'anira angapangire. Pankhaniyi, tikulimbikitsidwa kugwiritsa ntchito insulin yofulumira.

Hormashort ya Ultrashort imapereka mphamvu kwambiri. Mukasinthira ku Humalog, mlingo wake woyambirira amawerengedwa ngati 40% ya insulin yayifupi. Malinga ndi zotsatira za glycemia, mlingo umasinthidwa. Chofunikira pakukonzekera mkate uliwonse ndimagawo 1-1,5.

Zokhudza insulin yamakono

Pali zolephera zina pakugwiritsira ntchito insulin ya anthu, mwachitsanzo, kuyang'ana pang'onopang'ono (wodwala matenda ashuga ayenera kupereka jakisoni kwa mphindi 30 mpaka 40 asanadye) komanso nthawi yayitali kwambiri yogwira (mpaka maola 12), yomwe imakhala chinthu chofunikira kwambiri pakuchedwa hypoglycemia.

Kumapeto kwa zaka zana zapitazi, kufunikira kwakakulitsa mapangidwe a insulin omwe sangakhale opanda zolakwa izi. Ma insulin omwe amagwira ntchito mwachidule adayamba kupangidwa ndi theka lalifupi kwambiri la moyo.

Izi zinawabweretsa pafupi ndi mphamvu za insulin yakunja, yomwe imatha kulumikizidwa pambuyo pa mphindi 4-5 mutalowa m'magazi.

Mitundu ya insulin yopanda chopanda kanthu imatha kukhala yofanana komanso yodziwikika bwino kuchokera ku mafuta osakanikirana ndipo osaputa hypoglycemia yausiku.

Zaka zaposachedwa, pakhala kusintha kwakukulu mu pharmacology, chifukwa akuti:

• Kusintha kwa mayankho acidic kukhala ndale,
• kupeza insulin yaumunthu pogwiritsa ntchito tekinoloje ya DNA,
• kupanga kwa insulin mmalo wapamwamba kwambiri ndi mawonekedwe atsopano a pharmacological.

Ma insulin analogi amasintha nthawi ya zochita za munthu mahomoni kuti apereke njira yodziwika yolumikizira matupi a anthu odwala matenda ashuga.

Mankhwalawa amathandizira kuti athe kukwaniritsa bwino pakati pa zoopsa zothira m'magazi amwazi ndikwaniritsa glycemia yomwe mukufuna.

Mitundu yamakono ya insulin malinga ndi nthawi yomwe ikuchitika nthawi zambiri imagawidwa m'magulu:

1. ultrashort (Humalog, Apidra, Penfill),
2. yayitali (Lantus, Levemir Penfill).

Kuphatikiza apo, pali mankhwala osakanikirana omwe amaphatikizidwa, omwe ali osakanikirana ndi mahashoni a ultrashort komanso ma nthawi yayitali muyeso inayake: Penfill, Humalog mix 25.

Humalog (lispro)

Mu kapangidwe ka insulin iyi, malo a proline ndi lysine adasinthidwa. Kusiyana pakati pa mankhwalawa ndi insulin yaumunthu yamunthu ndi kuchepa kocheperako kwa mayanjano apakati. Poona izi, lispro imatha kumizidwa mwachangu kulowa m'magazi a munthu wodwala matenda ashuga.

Ngati muzibayira mankhwala omwe ali mgulu lomwelo komanso nthawi yomweyo, Humalog iperekanso msanga kwambiri 2 times mwachangu. Hormone iyi imachotsedwa mwachangu kwambiri ndipo patatha maola 4 kuyika kwake kumafika pachimake. Kukumana kwa insulin yaumunthu yosavuta kudzasungidwa mkati mwa maola 6.

Kuyerekeza Lyspro ndi insulin yaying'ono yokhala ndi kanthawi kochepa, titha kunena kuti zakale zingalepheretse shuga kukhala ndi chiwindi kwambiri.

Palinso mwayi wina wa mankhwala a Humalog - ndiwodziwikiratu ndipo ungathe kuyambitsa kusintha kwa mankhwalawa muzakudya zopatsa thanzi. Amadziwika ndi kusowa kwa kusintha kwakanthawi kofikira kuchokera pakuwonjezeka kwa kuchuluka kwa zinthu.

Kugwiritsa ntchito insulin yosavuta yaumunthu, kutalika kwa ntchito yake kumasiyanasiyana kutengera mlingo. Ndi chifukwa ichi kuti nthawi yayitali maola 6 mpaka 12 imayamba.

Ndi kuwonjezeka kwa mlingo wa insulin Humalog, kutalika kwa ntchito yake kumakhalabe kofanana pamlingo umodzi ndipo kudzakhala maola 5.

Pambuyo pake ndikuwonjezeka kwa mlingo wa lispro, chiopsezo cha kuchepa kwa hypoglycemia sichikula.

Aspart (Novorapid Penfill)

Mafuta a insulin amenewa angayerekezere bwino mayankho okwanira a insulin pakudya. Kutalika kwake kumapangitsa kuti pakhale zovuta pakati pa chakudya, zomwe zimapangitsa kuti pakhale gawo lathunthu pakulamulira shuga.

Ngati tifanizira zotsatira za mankhwalawa ndi ma insulin omwe ali ndi insulin wamba yodziwika bwino, kuwonjezereka kwa mkhalidwe wowongolera wa shuga yamagazi a postprandial kumadziwika.

Kuphatikiza mankhwala ndi Detemir ndi Aspart kumapereka mwayi:

• pafupifupi 100% imasintha mawonekedwe a tsiku lililonse la insulin,
• kusintha moyenera mulingo wa glycosylated hemoglobin,
• Amachepetsa mwayi wokhala ndi vuto la hypoglycemic,
• muchepetse matalikidwe ndi kuchuluka kwa magazi a anthu odwala matenda ashuga.

Ndizofunikira kudziwa kuti pochita mankhwala ndi basal-bolus insulin analogues, kuchuluka kwambiri kwa thupi kunatsika kwambiri kuposa nthawi yonse yowonera mwamphamvu.

Glulisin (Apidra)

Anulin ya insulin ya anthu ndi mankhwala owonetsa pang'onopang'ono. Malinga ndi pharmacokinetic yake, mawonekedwe a pharmacodynamic ndi bioavailability, Glulisin ndi wofanana ndi Humalog. Mu ntchito yake ya mitogenic ndi metabolic, timadzi tambiri timasiyana ndi insulin yosavuta ya munthu. Chifukwa cha izi, ndizotheka kugwiritsa ntchito nthawi yayitali, ndipo ndizotetezeka kwathunthu.

Monga lamulo, Apidra iyenera kugwiritsidwa ntchito kuphatikiza ndi:

1. insulin yayitali yaumunthu
2. basal insulin analogue.

Kuphatikiza apo, mankhwalawa amadziwika ndi kuyamba mwachangu pantchito komanso nthawi yofupikirapo kuposa mahomoni abwinobwino amunthu. Zimathandizira odwala omwe ali ndi matenda ashuga kuwonetsa kusinthasintha kwakukulu pakugwiritsa ntchito ndi chakudya kuposa timadzi ta munthu.Insulin imayamba kugwira ntchito yake atangoyambika, ndipo magazi a shuga amatsika patadutsa mphindi 10 mpaka Apidra atabayidwa jakisoni.

Popewa hypoglycemia mwa okalamba odwala, madokotala amalimbikitsa kuyambitsidwa kwa mankhwalawa mutangodya kapena nthawi yomweyo. Kutsika kwa mahomoni kumathandiza kupewa zomwe zimadziwika kuti "overlay", zomwe zimapangitsa kupewa hypoglycemia.

Itha kukhala othandiza kwa iwo onenepa kwambiri, chifukwa kugwiritsa ntchito sikumayambitsa kulemera kowonjezereka. Mankhwalawa amadziwika ndi kuyambika mofulumira kwa kuchuluka kwa ndende poyerekeza ndi mitundu ina ya mahomoni a nthawi zonse ndi a lispro.

Apidra ndi yabwino kwa madigiri osiyanasiyana onenepa kwambiri chifukwa chosinthasintha kwambiri. Mu kunenepa kwa mtundu wa visceral, kuchuluka kwa mayamwidwe kwa mankhwalawa kumatha kusintha, zimapangitsa kuti zikhale zovuta kwa prandial glycemic control.

Detemir (Levemir Penfill)

Levemir Penfill ndi analogue of insulin ya anthu. Ili ndi nthawi yogwira ntchito ndipo ilibe nsonga. Izi zimathandizira kuyang'anira basal glycemic masana, koma amagwiritsidwa ntchito kawiri.

Mothandizidwa ndi subcutaneally, Detemir amapanga zinthu zomwe zimalumikizana ndi serum albin mu madzi amkati. Pambuyo posamutsira kudzera khoma la capillary, insulin imamangirizanso ku albumin m'magazi.

Pokonzekera, ndi gawo laulere lokha lomwe likugwira ntchito mwachilengedwe. Chifukwa chake, kumangiriza albumin ndi kuvunda kwake pang'onopang'ono kumapereka ntchito yayitali komanso yopanda pake.

Levemir Penfill insulin imagwira wodwala yemwe ali ndi matenda ashuga bwino komanso amakwaniritsa zosowa zake zonse za insal insulin. Sipereka kugwedeza musanayambe makatani.

Glargin (Lantus)

Glargin insulin cholowa m'malo mwake imakhala yothamanga kwambiri. Mankhwala amatha kusungunuka bwino m'malo ena acidic, ndipo osalowerera ndale (m'mafuta onenepa) samasungunuka bwino.

Atangokhala subcutaneous makonzedwe, Glargin amalowa mu kusayanjana ndi mapangidwe a microprecipitation, komwe ndikofunikira kuti amasulidwe enanso a mankhwalawa komanso kugawa kwawo kukhala ma cell a insulin komanso ma dimers.

Chifukwa cha kuyenda kosadukiza komanso kwapang'onopang'ono kwa Lantus kulowa m'magazi a wodwala yemwe ali ndi matenda ashuga, kufalikira kwake mu njira kumachitika mkati mwa maola 24. Izi zimapangitsa kuti jakisoni wa mankhwala a insulin azitha kamodzi kokha patsiku.

Tikatulutsa zinc zochepa, inshuwaransi ya Lantus imalira m'misempha, yomwe imakulitsa nthawi yake. Mtheradi zonse za mankhwalawa zimatsimikizira mawonekedwe ake osalala komanso opanda chiyembekezo.

Glargin amayamba kugwira ntchito atatha mphindi 60 atabaya jekeseni wa subcutaneous. Mphamvu yake m'magazi a wodwala imatha kuthandizidwa pambuyo pa maola 2-4 kuyambira nthawi yoyamba kumwa mankhwala.

Mosasamala nthawi yeniyeni yovomerezeka ya jakisoni wa mankhwalawa (m'mawa kapena madzulo) ndi malo omwe jakisoni idzakhalire (m'mimba, mkono, mwendo), nthawi yowonekera kwa thupi idzakhala:

• pafupifupi - maola 24
• pazambiri - maola 29.

Kusintha kwa insulin Glargin kumatha kufanana ndi mahomoni achilengedwe pakuyenda kwawo kwambiri, chifukwa mankhwalawa:

1. Moyenerera amathandizira kudya shuga ndi zotumphukira zotengera insulin (makamaka mafuta ndi minofu),
2. amalepheretsa gluconeogeneis (amachepetsa).

Kuphatikiza apo, mankhwalawa amachepetsa kwambiri gawo logawanika la adipose minofu (lipolysis), kuwonongeka kwa mapuloteni (proteinolysis), pomwe amalimbikitsa kupanga minofu.

Kafukufuku wazamankhwala a Glargin's pharmacokinetics awonetsa kuti kugawa kosagwiritsa ntchito bwino kwa mankhwalawa kumapangitsa kuti pafupifupi 100% ikhale ndi fanizo loyambira la insulin ya insulin mkati mwa maola 24. Nthawi yomweyo, mwayi wokhala ndi machitidwe a hypoglycemic ndi kulumpha lakuthwa m'magazi a shuga amachepetsa kwambiri.

Kusakaniza kwa Humalog 25

Mankhwala awa ndi osakaniza omwe amakhala ndi:

• 75% yovala kuyimitsidwa kwa horpro ya mahomoni,
• 25% insulin Humalog.

Izi ndi mitundu ina ya insulin imaphatikizidwanso mogwirizana ndi njira yawo yotulutsira. Kutalika kwa mankhwalawa kumaperekedwa chifukwa cha kufalikira kwa mahomoni lyspro, zomwe zimapangitsa kubwereza kupanga kwapansi kwa mahomoni.

25% yotsala ya inshuwaransi ya lispro ndi gawo lomwe limakhala ndi nthawi yayitali yodziwonetsa, yomwe imakhudza glycemia atatha kudya.

Ndizofunikira kudziwa kuti Humalog mu kapangidwe kazosakaniza zimakhudza thupi mwachangu kwambiri poyerekeza ndi mahomoni afupiafupi. Imapereka chiwongolero chomaliza cha glycemia ya postpradial chifukwa chake mbiri yake imakhala yolimba poyerekeza ndi insulin yochepa.

Ma insulin osakanikirana amalimbikitsidwa makamaka kwa anthu omwe ali ndi matenda a shuga a 2. Gululi limaphatikizapo odwala okalamba omwe, monga lamulo, amavutika ndi mavuto a kukumbukira. Ichi ndichifukwa chake kuyambitsidwa kwa mahomoni musanadye kapena atangomaliza kumene kumathandiza kwambiri kukonza moyo wa odwala.

Kafukufuku wokhudzana ndi thanzi la odwala matenda ashuga omwe ali pagulu la zaka 60 mpaka 80 pogwiritsa ntchito mankhwala osakanikirana a Humalog 25 adawonetsa kuti adakwanitsa kulipidwa bwino chifukwa cha kagayidwe kazakudya. Mwanjira yovomerezeka ya mahomoni isanayambe komanso itatha kudya, madokotala adakwanitsa kuonda pang'ono komanso kutsika kwambiri kwa hypoglycemia.

Odwala omwe ali ndi matenda ashuga nthawi zambiri amafunika kugwiritsa ntchito mankhwala okhala ndi insulin.

Izi zimaphatikizapo Lizpro insulin, yomwe imagwiritsidwa ntchito kwambiri kuyendetsa shuga m'magazi.

Kuti mumvetsetse chithandizo chamankhwala ndi chithandizo chake, odwala ayenera kudziwa zazikulu za mankhwalawa.

Makhalidwe wamba

Dzina lamalonda lamankhwala ndi Humalog Mix. Zimakhazikika pa analogue ya insulin ya anthu. Katunduyo ali ndi vuto la hypoglycemic, amathandizira kuthamanga kwa glucose, komanso amawongolera momwe amasulidwire. Chidacho ndi yankho la magawo awiri.

Kuphatikiza pa chinthu chomwe chimagwira, mawonekedwewo ali ndi zinthu monga:

• metacresol
• glycerol
• sodium hydroxide mwanjira yothetsera (kapena hydrochloric acid),
• zinc oxide
• sodium heptahydrate hydrogen phosphate,
• madzi.

Kuti mugwiritse ntchito mankhwalawa, muyenera kupangira adokotala malangizo oyenera. Sizovomerezeka kusintha mlingo kapena ndandanda yogwiritsira ntchito nokha.

Pharmacological zochita ndi zikuwonetsa

Zochita za insulin yamtunduwu ndizofanana ndi mankhwala ena okhala ndi insulin. Zimalowa mthupi, chinthu chogwira ntchito chimalumikizana ndi nembanemba yama cell, motero zimapangitsa kuyamwa kwa glucose.

Njira ya mayamwidwe ake kuchokera ku plasma ndikugawa mkati mwa minofu imathandizira. Awa ndi gawo la insulin Lizpro mu malamulo a shuga.

Gawo lachiwiri lazomwe limakhudza thupi ndi kuchepa kwa kupanga kwa shuga m'maselo a chiwindi. Mwanjira iyi, shuga wambiri samalowa m'magazi. Malinga ndi izi, titha kunena kuti mankhwala a Humalog ali ndi hypoglycemic mbali ziwiri.

Insulin yamtunduwu imachita zinthu mwachangu ndipo imayambitsa mphindi 15 pambuyo pa kubayidwa. Izi zikutanthauza kuti izi zimatengedwa ndi thupi mwachangu. Chifukwa cha izi, amaloledwa kugwiritsa ntchito mankhwalawa pafupifupi asanadye.

Mlingo wa mayamwidwe umakhudzidwa ndi tsamba la jakisoni.Chifukwa chake, muyenera kuchita jakisoni, poganizira malangizo a mankhwalawo.

Ndikofunikanso kutsatira malingaliro a Lizpro insulin posankha kugwiritsa ntchito. Mankhwalawa ali ndi mphamvu kwambiri, chifukwa chake kugwiritsidwa ntchito kumaloledwa pokhapokha zikuwonetsa. Ngati mugwiritse ntchito mankhwalawa mosafunikira, mutha kuyambitsa zowonongeka zambiri ku thanzi lanu.

Zisonyezo zakusankhidwa kwa Humalog zikuphatikiza:

• mtundu woyamba wa matenda ashuga
• hyperglycemia, zomwe zimachitika zomwe sizigwirizana ndi kugwiritsa ntchito mankhwala ena,
• mtundu wachiwiri wa matenda a shuga (posakhalitsa chifukwa chogwiritsa ntchito mankhwala osokoneza pakamwa),
• opaleshoni yopanga odwala matenda ashuga,
• kupezeka kwa mwatsatanetsatane matenda omwe amasokoneza shuga,
• mtundu wina wa insulin tsankho.

Koma ngakhale pali zisonyezo zakumwa mankhwalawa, adotolo ayenera kuunika wodwalayo ndikuwonetsetsa kuti palibe zotsutsana ndi kuyenera kwa mankhwalawa.

Malangizo ogwiritsira ntchito

Kuti mupewe mavuto chifukwa chogwiritsa ntchito Lizpro insulin, muyenera kutsatira mosamalitsa malangizo omwe mankhwalawa amachokera.

Mlingo wa mankhwalawa umatengera mawonekedwe ambiri. Izi zimakhudza msinkhu wa wodwalayo, mawonekedwe a matendawa ndi kuuma kwake, matenda oyanjana ndi zina zina.

Koma katswiriyo akhoza kukhala akulakwitsa, chifukwa chake njira ya chithandizo iyenera kuyang'aniridwa ndikuwunika shuga nthawi zonse ndikuwasintha mayendedwe ake. Wodwalayo amayeneranso kukhala ndi chidwi ndi thanzi lake ndikudziwitsa dotolo za zoyipa zilizonse zomwe zimachitika m'thupi ndi mankhwalawo.

Humalog imakhala yoyendetsedwa mosavuta. Koma mosiyana ndi mankhwala ofanana ndi ena, jakisoni wa intramus amaloledwa, komanso kuyambitsa insulin m'mitsempha. Jakisoni wamkati ayenera kuchitidwa ndi kutenga gawo la othandizira azaumoyo.

Malo oyenera a jakisoni wotsekemera ndi malo a ntchafu, malo amapewa, matako, matumbo am'mimba. Kukhazikitsidwa kwa mankhwala m'dera lomwelo sikuloledwa, chifukwa izi zimayambitsa lipodystrophy. Kuyenda pafupipafupi mkati mwa malo osankhidwa ndikofunikira.

Zingwe ziyenera kuchitika nthawi imodzi yatsiku. Izi zimalola kuti thupi lizisinthasintha ndikupereka chidziwitso mosalekeza ku insulin.

Ndikofunika kwambiri kuganizira zovuta zaumoyo wa wodwala (kupatula matenda ashuga). Chifukwa cha ena a iwo, zovuta za chinthuchi zimatha kupotozedwa mpaka pansi. Pankhaniyi, muyenera kuwerengeranso mlingo. Pokhudzana ndi ma pathologies ena, dokotala akhoza kuletsa kugwiritsa ntchito Humalog.

Phunziro la kanema wa syringe:

Zotsatira zoyipa ndi contraindication

Ndikosavuta kutsimikizira kusowa kwa zovulaza pogwiritsa ntchito mankhwalawa, koma zoopsa zimatha kuchepetsedwa, malinga ndi zomwe zidalipo kale. Lizpro amakhalanso nawo, ndipo adotolo, ndikumuika, ayenera kuwonetsetsa kuti wodwalayo alibe.

Milandu yayikulu ndi:

• chidwi cha munthu pazigawo za mankhwala,
• kukonda kwambiri hypoglycemia,
• kukhalapo kwa insulinomas.

Zikatero, Humalog iyenera m'malo mwake ndi mankhwala ena omwe ali ndi vuto lofananalo, koma osakhala chowopsa.

Komanso, mukamathandizira ndi insulin, ndikofunikira kuganizira zovuta zoyipa. Kupezeka kwa ena a iwo sikubweretsa chiwopsezo, chifukwa zimachitika chifukwa cha kusakwazi kwa thupi kwa chinthu chomwe chikugwira.

Pakapita kanthawi kochepa, munthu amazolowera jakisoni, ndipo mavuto amatha. Gulu lina la zotsatira zoyipa likusonyeza kukhalapo kwa tsankho pa chinthu ichi. Zizindikiro izi sizitha ndi nthawi, koma kupita patsogolo pokhapokha, ndikupanga ngozi yayikulu. Ngati zikuchitika, tikulimbikitsidwa kuletsa chithandizo ndi wothandizila wa insulin.

Nthawi zambiri amatchedwa zoyipa za Humalog, monga:

Zochitika zilizonse zachilendo zikachitika, wodwalayo ayenera kufunsa dokotala kuti awonetsetse kuti palibe chowopsa.

Zomwe zimayenderana ndi mankhwala ena

Chofunikira kwambiri pamankhwala aliwonse ndizofanana ndi mankhwala ena. Madokotala nthawi zambiri amayenera kuchitira ma pathologies angapo nthawi imodzi, chifukwa chomwe ndikofunikira kuphatikiza kulandila kwa mankhwala osiyanasiyana. Ndikofunikira kuti mupange mankhwalawo kuti mankhwalawo asatseke kuchitirana.

Nthawi zina pamakhala kufunika kogwiritsa ntchito mankhwala omwe amatha kusokoneza zochita za insulin.

Mphamvu yake imalimbikitsidwa ngati, kuwonjezera pamenepo, wodwala amatenga mitundu yotsatirayi ya mankhwala:

• Clofibrate
• Ketoconazole,
• Mao zoletsa
• sulfonamides.

Ngati simungakane kuzilandira, muyenera kuchepetsa kuchuluka kwa Humalog yomwe yakambidwayo.

Zinthu zotsatirazi ndi magulu a othandizira amatha kufooketsa mphamvu ya mankhwalawo omwe mukufunsidwa:

• estrogens
• chikonga
• mahomoni mankhwala oletsa kubereka,
• Glucagon.

Chifukwa cha mankhwalawa, kugwira ntchito kwa Lizpro kumatha kuchepa, chifukwa chake dokotala amayenera kuti alimbikitse kuchuluka.

Mankhwala ena ali ndi zotsatira zosayembekezereka. Amatha kuwonjezera ndikuchepetsa ntchito yogwira ntchito. Izi zikuphatikizapo Octreotide, Pentamidine, Reserpine, beta-blockers.

Malangizo apadera

Pochiza Humalog, zina mwa mawonekedwe ake ziyenera kukumbukiridwa.

Mwa iwo amatchedwa:

Dotolo ayenera kudziwitsa onse za mawonekedwe a wodwala. Pamodzi ndi wodwala, akuyenera kuwunika momwe amakhalira komanso zizolowezi zake kuti asankhe njira yoyenera yoyenera.

Mtengo ndi fanizo la mankhwala

Kuchiza ndi Insulin Lyspro ndi okwera mtengo. Mtengo wa phukusi limodzi la mankhwalawa umasiyanasiyana 1800 mpaka 200 rubles. Ndi chifukwa cha kukwera mtengo komwe odwala nthawi zina amapempha dokotala kuti athetse mankhwalawa ndi analogue yawo ndi mtengo wotsika mtengo.

Pali zambiri zofananira za mankhwalawa. Amayimiridwa ndi mitundu yosiyanasiyana ya kumasulidwa, amatha kusiyanasiyana pakupanga kwawo.

Mwa zina zazikulu zingatchulidwe:

Kusankha kwa mankhwala kuti athetse insulin yamtunduwu kuyenera kuperekedwa kwa katswiri.

Humalog ndi mankhwala osokoneza bongo a hypoglycemic, analog of yochepa insulin.

Kutulutsa mawonekedwe ndi kapangidwe kake

Humalog imapangidwa ngati njira yankho la intravenous (iv) ndi subcutaneous (s / c) kayendetsedwe: kopanda utoto, wowonekera (m'makatata a 3 ml, pamatumba a chithuza cha ma cartridge 5, mu makatoni okhala ndi 1 blister pack, mu ma syringe phula la QuickPen), makatoni okhala ndi 3 ml ya yankho amataikidwa m'makatoni a ma cholembera asanu).

Muli 1 ml ya yankho:

• yogwira mankhwala: insulin lispro - 100 ME,
• othandizira: madzi a jakisoni - mpaka 1 ml, yankho la sodium hydroxide 10% ndi (kapena) yankho la hydrochloric acid 10% - mpaka pH 7-8, sodium hydrogen phosphate heptahydrate - 0,00188 g, zinc oxide - ya Zn ++ 0.000 0197 g , metacresol - 0,00315 g, glycerin (glycerol) - 0,016 g.

Mlingo ndi makonzedwe

Mlingo wa mankhwalawa amatsimikiziridwa ndi dokotala payekhapayekha, poganizira kuchuluka kwa shuga m'magazi.

Njira yothetsera vutoli ndi jekeseni wa iv - ngati kuli kotheka, pazochitika pachimake, ketoacidosis, pakati pa ntchito ndi nthawi ya postoperative, s / c - mawonekedwe a jakisoni kapena infusions (kudzera pampu ya insulin) pamimba, matako, m'chiuno kapena phewa, osati kulola kuti mankhwala alowe m'mitsempha yamagazi. Masamba a jakisoni amasinthidwa nthawi iliyonse, kuti malo omwewo sagwiritsidwe ntchito zoposa 1 nthawi pamwezi. Pambuyo pa kutsata, tsamba la jakisoni silingathetsedwenso.

Munthawi zonsezi, njira yoyendetsera amakhazikitsidwa payokha. Kukhazikitsidwa kumachitika musanadye chakudya, koma kugwiritsa ntchito mankhwalawa kumaloledwa pambuyo chakudya.

Kukonzekera kwa mankhwala

Musanagwiritse ntchito, yankho lake limayang'anidwa chifukwa cha zinthu, phokoso, madontho komanso makulidwe.Gwiritsani ntchito njira yokhayo yopanda utoto ndi yowoneka bwino kutentha kwa chipinda.

Pamaso pa jekeseni, tsukani manja anu bwino, sankhani ndikupukuta malowo. Kenako, kachipuyo kamachotsedwa singano, khungu limakoka kapena kusungidwa mu khola lalikulu, singano imayilowetsedwa ndipo batani limakanikizidwa. Pambuyo pake, singano imachotsedwa ndipo kwa masekondi angapo malo a jakisawo amapanikizidwa mosamala ndi swab thonje. Pogwiritsa ntchito singano yodzitchinjiriza, imatembenuzidwa ndikuitaya.

Musanagwiritse ntchito Humalog mu cholembera-injector (jakisoni), QuickPen ayenera kuwerenga malangizo kuti agwiritse ntchito.

Jakisoni wa IV amachitika motsatira chizolowezi chazachipatala, mwachitsanzo, jakisoni wa IV Kuwunikira pafupipafupi kuchuluka kwa shuga m'magazi ndikofunikira.

Kukhazikika kwa kulowetsedwa ndi kuzungulira kwa 0-1-1 IU pa 1 ml ya insulin lispro mu 5% dextrose kapena 0,9% sodium chloride njira yothetsera masiku 2 imaperekedwa ngati imasungidwa kutentha kwa chipinda.

Pochita ma infusions a scet, mapampu a Disetronic ndi Minimed opangidwira insulin infusions angagwiritsidwe ntchito. Ndikofunikira kutsatira mosamalitsa malangizo a wopanga ndikutsatira malamulo a asepticism mukalumikiza dongosolo. Masiku 2 aliwonse amasintha dongosolo la kulowetsedwa. Kulowetsedwa ndi gawo la hypoglycemic kuyimitsidwa mpaka kuthe. Pankhani yotsika kwambiri m'magazi m'magazi, wodwalayo ayenera kufunsa dokotala kuti agwirizane ndikuletsa kulowetsedwa kwa insulin.

Kukwera msanga m'magazi a glucose kumatha kuonedwa ndi dongosolo lotsekeka la kulowetsedwa kapena kupopera mphamvu. Ngati kuphwanya kwa insulin yobereka kumayikiridwa ngati chifukwa chowonjezera kuchuluka kwa shuga, wodwalayo ayenera kutsatira malangizo a wopanga ndikudziwitsa adokotala (ngati kuli kofunikira).

Humalog mukamagwiritsa ntchito pampu sangaphatikizidwe ndi ma insulini ena.

Cholembera cha insulin ya QuickPen chili ndi 3 ml ya mankhwalawa ndi zochitika za 100 IU mu 1 ml. 1-60 mayunitsi a insulin amatha kuperekedwa pa jekeseni iliyonse. Mlingo ukhoza kukhazikitsidwa ndi kulondola kwa chinthu chimodzi. Ngati mayunitsi ambiri akhazikitsidwa, mlingowo ungakonzedwe popanda kutaya insulin.

Jakisoni amayenera kugwiritsidwa ntchito ndi wodwala m'modzi yekha, singano zatsopano ziyenera kugwiritsidwa ntchito pobayira iliyonse. Osagwiritsa ntchito jakisoni ngati chilichonse mwa mbali zake chiwonongeka kapena chosweka. Wodwalayo nthawi zonse azinyamula jakisoni wopopera kuti atayika kapena kuwonongeka.

Odwala omwe ali ndi vuto lowona kapena kutayika kwamaso samalimbikitsidwa kugwiritsa ntchito jakisoni popanda kuthandizidwa ndi anthu owoneka bwino omwe amaphunzitsidwa kuti azigwiritsa ntchito.

Jekeseni aliyense asanafike, ndikofunikira kutsimikizira kuti tsiku lotha ntchito lomwe lawonetsedwa pa cholembapo sichinathe ndipo kuti mtundu woyenera wa insulin uli ndi jakisoni. Pankhaniyi, sikulimbikitsidwa kuti muchepetse chizindikiro.

Mtundu wa batani lothamanga la cholembera cha QuickPen ndi imvi, umafanana ndi mtundu wa Mzere palemba lawo ndi mtundu wa insulin yomwe imagwiritsidwa ntchito.

Musanagwiritse ntchito jakisoni, muyenera kuonetsetsa kuti singanoyo imalumikizidwa kwathunthu ndi iyo. Mukatha kugwiritsa ntchito, singano imachotsedwa ndikuitaya. Cholembera sichingatheke kusungidwa ndi singano yolumikizidwa ndi iyo, chifukwa izi zimapangitsa kuti thovu la mpweya lipange cartridge ya mankhwala.

Popereka mankhwala opitilira muyeso 60, jakisoni awiri amachitidwa.

Kuti muwone zotsalira za insulini mu katiriji, muyenera kuloza jakisoni ndi nsonga ya singano kuti muwone kuchuluka kwa insulin yomwe ili pachikwangwani chonyamula cartridge. Chizindikiro ichi sichikugwiritsidwa ntchito kukhazikitsa mlingo.

Kuti muchotse kapu kuchokera ku jakisoni, muyenera kukoka. Ngati pali zovuta zilizonse, zungulirani mosamala nthawi yomweyo ndikuzikoka, kenako ndikukoka.

Nthawi iliyonse musanalowe jakisoni, amawunikira insulin, popeza popanda iwo mutha kupeza insulin yochepa kwambiri kapena yambiri. Kuti muwone, chotsani singano yakunja ndi yamkati ya singano, potembenuza batani la mlingo, mayunitsi awiri akhazikitsidwa, jekeseni amawongoleredwa kumtunda ndikugogoda pa cholembera kuti mpweya wonse usonkhane kumtunda. Kenako akanikizire batani la mlingo mpaka litayima ndipo nambala 0 ipezeka pazenera la dokotala. Kuyika batani m'malo opezekanso, pang'onopang'ono kuwerengera mpaka 5, panthawiyi insulin ikayamba kuwonekera kumapeto kwa singano. Ngati tsenga la insulin silikuwoneka, singano imasinthidwa ndi yatsopano ndikuyambiranso.

Kupereka mankhwala

• chotsani chipewa mu syringe cholembera
• ndi swab wothira mowa, pukuta chotupa cha kumapeto kwa chotengera,
• ikani singano mu kapu mwachindunji pamphepete mwa jakisoni ndikuyinya mpaka itaphatikizika kwathunthu,
• potembenuza batani la mlingo, chiwerengero chofunikira chayikidwa,
• chotsani chovalacho ndi singano ndikuchiyika pansi pa khungu.
• ndi chala chanu, kanikizani batani la mlingo mpaka litayima kwathunthu. Kuti mulowetse mlingo wathunthu, gwiritsani batani ndipo pang'onopang'ono muwerenge mpaka 5,
• singano imachotsedwa pakhungu.
• onani chizindikiro - ngati chili ndi nambala 0, mankhwalawo alembetsedwa kwathunthu,
• ikani chotsekera chakunja pa singano ndikuchotsa kumakina, kenako nkutaya,
• ikani chipewa pa syringe cholembera.

Ngati wodwala akukayikira kuti wapereka mlingo wonse, sayenera kupatsanso mlingo wobwereza.

Kuyanjana kwa mankhwala

Zotsatira za mankhwala / zinthu pa insulin lispro ndi mankhwala osakanikirana:

• phenothiazine derivatives, nicotinic acid, lithiamu carbonate, isoniazid, diazoxide, chlorprotixene, thiazide diuretics, triceclic antidepressants, beta-2-adrenergic agonists (terbutaline, salbutamol, ritodrin, etc.), danazoleroidones kuopsa kwa mphamvu yake yamatsenga,
• angiotensin II receptor antagonists, octreotide, angiotensin - kutembenuza ma enzyme inhibitors (enapril, Captopril), ma antidepressants (monoamine oxidase inhibitors), mankhwala a sulfanilamide, salicylates (acetylsalicylic acid, etc., mankhwala a phencygencotic, hypogly ethanol ndi ethanol-mankhwala, beta-blockers: kuonjezera zovuta zake hypoglycemic kwenikweni.

Lyspro insulin yosakanikirana ndi insulin ya nyama.

Musanamwe mankhwala ena, ndikofunikira kukaonana ndi dokotala. Malinga ndi lingaliro lake, mankhwalawa amatha kugwiritsidwa ntchito limodzi ndi insulin yaumunthu wamkati kapena mitundu yamkamwa ya sulfonylureas.

The fanizo la Humalog ndi Iletin I wokhazikika, Iletin II wokhazikika, Inutral SPP, Inutral HM, Farmasulin.

Terms a Tchuthi cha Pharmacy

Yoperekedwa ndi mankhwala.

Kodi mwapeza cholakwika m'mawuwo? Sankhani ndikusindikiza Ctrl + Lowani.

Ngakhale kuti asayansi adatha kubwereza molekyulu yonse ya insulin yomwe imapangidwa m'thupi la munthu, zochita za mahomoni adasinthiratu chifukwa zimafunikira nthawi yoyenera kunyamulidwa m'magazi. Mankhwala oyamba osinthika anali insulin Humalog. Imayamba kugwira ntchito patangodutsa mphindi 15 jakisoni, choncho shuga yochokera m'mwaziyo imasamutsidwira minofu yake munthawi yake, ndipo ngakhale hyperglycemia yochepa siyimachitika.

Ndikofunikira kudziwa! Nkhani yatsopano yomwe ikulangizidwa ndi ma endocrinologists a Kuwunika Kwachisawawa Kokulu! Ndi zofunika tsiku lililonse.

Poyerekeza ndi ma insulins omwe adapangidwa kale, Humalog ikuwonetsa zotsatira zabwino: mwa odwala, kusinthasintha kwa tsiku ndi tsiku kwa shuga kumachepetsedwa ndi 22%, magirisi am'magazi amayenda bwino, makamaka masana, ndipo mwayi wa kuchepa kwambiri kwa hypoglycemia umachepa.Chifukwa chachangu, koma chokhazikika, insulin iyi imagwiritsidwa ntchito kwambiri mu shuga.

Ndondomeko ya jekeseni

Chakudya chimayalidwa chakudya chilichonse chisanachitike. osachepera katatu patsiku . Pankhani ya shuga wambiri, mawonekedwe okhathamira pakati pa jakisoni wamkulu amaloledwa. Malangizo ogwiritsira ntchito akutsimikizira kuwerengera kuchuluka kwa insulini yochokera pamafuta omwe akukonzekera chakudya chotsatira. Pafupifupi mphindi 15 ayenera kuchokera jakisoni kupita chakudya.

Malinga ndi ndemanga, nthawi ino nthawi zambiri zimakhala zochepa, makamaka masana, pomwe insulin kukana imakhala yotsika. Mlingo wa mayamwidwe ndi munthu payekhapayekha, umatha kuwerengeka pogwiritsa ntchito kuchuluka kwa shuga m'magazi pambuyo pobayidwa. Ngati kutsitsa kwa shuga kumawonedwa mwachangu kuposa momwe malangizowo amafunikira, nthawi yomwe chakudya chisanachitike iyenera kuchepetsedwa.

Humalog ndi imodzi mwamankhwala omwe amafulumira kwambiri, motero ndikosavuta kugwiritsa ntchito ngati thandizo ladzidzidzi kwa odwala matenda ashuga ngati wodwala ali pachiwopsezo.

Nthawi yogwira (yochepa kapena yayitali)

Peak ya insulin ya ultrashort imawonedwa patatha mphindi 60 kuchokera pakukhazikitsa. Kutalika kwa zochita zimatengera mlingo; kukula kwake ndikutalika kwa shuga, pafupifupi - pafupifupi maola 4.

Kusakaniza kwa Humalog 25

Kuti muwone molondola momwe Humalog ikuyendera, shuga ayenera kuyesedwa pambuyo pa nthawi imeneyi, nthawi zambiri izi zimachitika chakudya chisanafike. Miyeso yoyambirira imafunikira ngati hypoglycemia ikukayikira.

Doctor of Medical Science, Mutu wa Institute of Diabetesology - Tatyana Yakovleva

Ndakhala ndikuphunzira matenda a shuga kwa zaka zambiri. Zimakhala zowopsa anthu ambiri akamwalira, ndipo makamaka amakhala olumala chifukwa cha matenda ashuga.

Ndithamangira kunena mbiri yabwino - Endocrinological Research Center ya Russia Academy of Medical Science idatha kupanga mankhwala omwe amachiritsiratu matenda ashuga. Pakadali pano, kugwiritsa ntchito bwino kwa mankhwalawa kuyandikira 98%.

Nkhani ina yabwino: Unduna wa Zaumoyo wapanga kukhazikitsidwa komwe kumalipirira mtengo wokwera wa mankhwalawo. Ku Russia, odwala matenda ashuga mpaka Marichi 2 nditha kuipeza - Kwa ma ruble 147 okha!

Kutalika kwakanthawi kwa Humalog si koyipa, koma mwayi wa mankhwalawa. Tikuthokoza, odwala omwe ali ndi matenda osokoneza bongo sakhala ndi vuto la hypoglycemia, makamaka usiku.

Kusakaniza Kwa Humalog

Kuphatikiza pa Humalog, kampani yopanga zamankhwala Lilly France imatulutsa Humalog Remix. Ndiosakanikirana kwa lyspro insulin ndi protamine sulfate. Chifukwa cha kuphatikiza uku, nthawi yoyambira ya mahomoni imakhalabe mwachangu, ndipo nthawi yochitapo kanthu imawonjezeka kwambiri.

Kusintha kwa Humalog kumapezeka mu 2indi:

Ubwino wokhawo wa mankhwalawa ndi regimen yosavuta. Kulipira shuga kwa odwala matenda ashuga ndi kagwiritsidwe ntchito kwawo ndi koipa kuposa kukhala ndi mankhwalawa a insulin komanso kugwiritsa ntchito mtundu wina wa Humalog ana Humalog Mix sagwiritsidwa ntchito .

Insulin iyi imayikidwa:

1. Anthu odwala matenda ashuga omwe sangathe kuwerengera payekha payekha kapena kupanga jakisoni, mwachitsanzo, chifukwa cha kusawona bwino, ziwalo kapena kugwedezeka.
2. Odwala omwe ali ndi matenda amisala.
3. Okalamba odwala omwe ali ndi zovuta zambiri za matenda ashuga komanso kuperewera koyipa kwa chithandizo ngati sakufuna kuphunzira.
4. Anthu odwala matenda ashuga omwe ali ndi matenda amtundu wa 2, ngati mahomoni awo akupangidwabe.

Kuchiza matenda a shuga ndi Humalog Remix kumafuna kudya mosasangalatsa yunifolomu, zakudya zazovomerezeka pakati pa chakudya. Amaloledwa kudya mpaka 3 XE pa chakudya cham'mawa, mpaka 4 XE pachakudya chamadzulo komanso chamadzulo, pafupifupi 2 XE pachakudya chamadzulo, ndi 4 XE asanagone.

Ma Analogi a Humalog

Lyspro insulin monga chinthu chogwira imangopezeka mu Humalog yoyambayo. Mankhwala osokoneza bongo ndi (ozikidwa pa aspart) ndi (glulisin). Zida izi ndizoperewera -fupi, choncho zilibe kanthu kuti muzisankha iti. Zonse zimalekeredwa bwino ndipo zimapereka shuga msanga.Monga lamulo, zokonda zimaperekedwa kwa mankhwalawa, omwe amatha kupezeka kwaulere kuchipatala.

Kusintha kuchokera ku Humalog kupita ku analogue yake kungakhale kofunikira pakakhala zovuta zina. Ngati wodwala matenda ashuga amatsatira zakudya zamafuta ochepa, kapena amakhala ndi hypoglycemia, ndizosavuta kugwiritsa ntchito anthu m'malo mwa insulin.

Onetsetsani kuti mwaphunzira! Kodi mukuganiza kuti kuyamwa kwa mapiritsi ndi insulini kwa nthawi yonse yokhayo ndi njira yokhayo yosungira shuga m'manja? Sichowona! Mutha kutsimikizira izi nokha ndikuyamba kuzigwiritsa ntchito.

DNA imabweretsanso insulin.
Kukonzekera: HUMALOG®
The yogwira mankhwala: insulin lyspro
ATX Encoding: A10AB04
KFG: Insulin yofulumira ya anthu
Nambala yolembetsa: P. 015490/01
Tsiku lolembetsa: 02.02.04
Mwini reg. acc: LILLY FRANCE S.A.S.

Njira yothetsera jakisoni ndi yowonekera, yopanda utoto.

1 ml
insulin lispro *
100 IU

Omwe amathandizira: glycerol, zinc oxide, sodium hydrogen phosphate, m-cresol, madzi d / ndi, hydrochloric acid yankho la 10% ndi sodium hydroxide solution ya 10% (kupanga pH yofunikira).

3 ml - makatoni (5) - matuza (1) - mapaketi a makatoni.

* Dongosolo la mayiko ena omwe siali eni ake omwe amavomerezedwa ndi WHO, ku Russian Federation, matchulidwe a dzina lapadziko lonse - insulin lispro amavomerezedwa.

Kufotokozera kwa mankhwalawa kumatengera malangizo ovomerezeka omwe angagwiritsidwe ntchito.

Humalog insulini mu cholembera

Humalog ndi mankhwala osokoneza bongo omwe ali ndi insulin yachilengedwe yopangidwa ndi thupi la munthu. DNA ndi njira yosinthira. Chodabwitsa ndichakuti Humalog imasintha kapangidwe ka amino acid m'maketeni a insulin. Mankhwala amawongolera kagayidwe kakang'ono ka shuga m'thupi. Zimatengera mankhwala okhala ndi zotsatira za anabolic.

Kubaya jakisoni kumathandizira kukulitsa kuchuluka kwa glycerol, mafuta acids ndi glocogen m'thupi. Imathandizira kuthamangitsa kaphatikizidwe ka mapuloteni. Njira yothetsera kumwa kwa amino acid imathandizira, zomwe zimapangitsa kuchepa kwa ketogeneis, glucogenogeneis, lipolysis, glycogenolysis, mapuloteni catabolism. Mankhwalawa ali ndi kanthawi kochepa.

Gawo lalikulu la Humalog ndi insulin lispro. Komanso, kapangidwe kameneka kamathandizidwa ndi oyambitsa zochitika zapakhomo. Palinso mitundu yosiyanasiyana ya mankhwalawa - Humalogmix 25, 50 ndi 100. Kusiyanitsa kwake kwakukulu ndi kukhalapo kwa Hagedorn mu proitamin yosalowerera, yomwe imachepetsa mphamvu ya insulin.

Manambala 25, 50 ndi 100 akuwonetsa kuchuluka kwa NPH pamankhwala. Humalogmix yowonjezereka yomwe imakhala ndi kulowererapo kwa Hagedorn, m'pamenenso mankhwala omwe angagwiridwe ntchito amatha kuchita. Chifukwa chake, mutha kuchepetsa kufunika kwa jakisoni yambiri, yopangidwira tsiku limodzi. Kugwiritsa ntchito mankhwalawa kumathandizira kuchiza matenda okoma komanso kumapangitsa moyo kukhala wosavuta.

Monga mankhwala aliwonse a Humalogmix 25, 50 ndi 100 ali ndi zovuta.

Mankhwala salola kupanga chiwonetsero chokwanira pa magazi a shuga.

Palinso milandu yokhudzana ndi chifuwa cha mankhwalawa ndi zovuta zina. Madokotala nthawi zambiri amapereka insulin Humalog mu mawonekedwe ake osavuta m'malo osakanikirana, popeza kuchuluka kwa 25, 50 ndi 100 NPHs kumatha kuyambitsa zovuta za matenda ashuga, nthawi zambiri amatha kudwala. Ndiwothandiza kwambiri kugwiritsa ntchito mitundu komanso mankhwalawa pochiza odwala okalamba omwe ali ndi matenda ashuga.

Nthawi zambiri, kusankha kwa mankhwalawa kumachitika chifukwa chakuyembekezerera kwakanthawi kochepa kwa odwala komanso kukula kwa demokalase. Pazigawo zotsala za odwala, Humalog mu mawonekedwe ake oyera amalimbikitsidwa.

Mankhwalawa amapezeka ngati kuyimitsidwa kwa jakisoni pansi pa khungu. The yogwira ndi insulin lispro 100 IU.

Zowonjezera zinalembedwe:

• 1.76 mg metacresol,
• 0,80 mg wa phenol madzi,
• 16 mg a glycerol (glycerol),
• 0,28 mg proitamin sulfate,
• 3.78 mg wa sodium hydrogen phosphate,
• 25 mcg wa zinc oxide,
• 10% hydrochloric acid solution,
• Kufikira 1 ml ya madzi a jakisoni.

Thupi limayera ndi utoto, wokhoza kufalikira. Zotsatira zake zimakhala zoyera komanso zamadzimadzi zomveka zomwe zimasonkhana pamwamba pa mpweya. Kuti mupeze jakisoni, ndikofunikira kusakaniza madzi omwe amapangidwa ndi matope mwa kugwedeza mopepuka ma ampoules. Humalog ikukhudzana ndi njira zophatikiza ma insulin achilengedwe ndi nthawi yayitali komanso yochepa kuchitira.

Sakanizani 50 Quicken ndi chisakanizo chothamangira mwachangu kwa insulin (yankho la insulin lispro 50%) ndi sing'anga kanthu (proitamin kuyimitsidwa insulin lispro 50%).

Cholinga cha chinthu ichi ndikuwongolera kagayidwe kachakudya ka shuga m'thupi. Zochita za Anabolic komanso zotsutsa-catabolic m'maselo osiyanasiyana a thupi zimadziwikanso.

Lizpro ndi insulin, yomwe imafanananso ndi mahomoni opangidwa m'thupi la munthu, ngakhale kuchepa kwathunthu kwa shuga mumagazi kumachitika mwachangu, koma zotsatira zake zimakhala zochepa. Kumwirira kwathunthu m'magazi ndikuyamba kwa zomwe zikuyembekezeka kuchitazi mwachindunji zimatengera zifukwa zingapo:

• Masamba a jekeseni (kulowetsa pamimba, m'chiuno, matako),
• Mlingo (kuchuluka kwa insulini),
• kayendedwe ka magazi
• kutentha kwa thupi kwa wodwalayo
• kulimbitsa thupi.

Mutapanga jakisoni, mphamvu ya mankhwalawa imayamba pakatha mphindi 15 zotsatira. Nthawi zambiri, kuyimikako kumayilowetsedwa pakhungu pakatsala mphindi zochepa asanadye, zomwe zimathandiza kuti pasakhale shuga. Poyerekeza, mphamvu ya lyspro insulin ingafaniziridwe ndi zomwe amachita ndi insulin ya munthu - isophan, yemwe zochita zake zimatha mpaka maola 15.

Ponena za kugwiritsa ntchito moyenera mankhwalawa monga Humalogmix 25, 50 ndi 100, malangizo ogwiritsira ntchito adzafunika. Tiyenera kukumbukira kuti mankhwalawa amagwiritsidwa ntchito mu matenda a shuga pochiza odwala amisinkhu yosiyanasiyana, kwa moyo wabwinobwino womwe insulin imafunikira tsiku ndi tsiku. Mlingo wofunikira komanso kuchuluka kwa makonzedwe kungathe kutsimikiziridwa ndi dokotala.

Pali njira zitatu zovomerezeka:

Pochiza matenda a shuga kunyumba, akatswiri akulangizani DiaLife . Ichi ndi chida chapadera:

• Amasinthasintha shuga
• Amayang'anira ntchito ya pancreatic
• Chotsani puffness, limayendetsa madzi kagayidwe
• Amawongolera masomphenya
• Zoyenera akulu ndi ana.
• Alibe zotsutsana

Timapereka kuchotsera kwa owerenga tsamba lathu!

Gulani pa tsamba lovomerezeka

• pansi pa khungu
• kudzera m'mitsempha
• kudzera m'mitsempha.

Akatswiri okhawo omwe amatha kuperekera mankhwalawa mwachisawawa mu mawonekedwe a inpatient. Izi ndichifukwa choti kudziyang'anira wekha mwanjira imeneyi kumakhala ndi zoopsa zina. Kathumba katemera wa insulin adapangira kuti aziziritsa cholembera kwa odwala matenda ashuga. Kuyambitsa motere kumachitika kokha pakhungu.

Humalog imalowetsedwa m'thupi kupitilira mphindi 15. musanadye, kapena mwachangu mphindi imodzi mutatha kudya. Pafupipafupi jakisoni amatha kusiyanasiyana kanayi mpaka katatu patsiku limodzi. Odwala akamamwa insulin yayitali, jakisoni wa mankhwalawa amachepetsedwa katatu pa tsiku. Ndi choletsedwa kupitirira muyeso wokwanira womwe madokotala amapereka ngati palibe chifukwa chofunikira chofunikira.

Kufanana ndi mankhwalawa, ma fanizo ena a mahomoni achilengedwe amaloledwa. Imayendetsedwa ndikuphatikizira zinthu ziwiri mu cholembera chimodzi, zomwe zimapangitsa kuti jakisoni azikhala mosavuta, osavuta komanso otetezeka. Jekeseni asanayambe, katoni ndi zinthuzo zimayenera kusakanikirana mpaka osalala, ndikugudubuza m'manja mwanu. Simungagwedezeni chidebe ndi mankhwalawa kwambiri, popeza pali chiopsezo chopanga chithovu, kuyambitsa kwake komwe sikofunikira.

Malangizowa akutsatira njira yotsatira, momwe mungagwiritsire ntchito Humalogmix molondola:

• Choyamba, muyenera kusamba manja anu bwino, kugwiritsa ntchito sopo nthawi zonse.
• Tsimikizani tsamba la jakisoni, lipukuteni ndi disk disk.
• Ikani cartridge mu syringe, ndikugwedezani pang'onopang'ono mbali zosiyanasiyana. Chifukwa chake chinthucho chimakhala chofanana, chimakhala chowonekera komanso chosakongola. Gwiritsani ntchito ma cartridge okha ndi amadzimadzi opanda zotsalira.
• Sankhani mlingo wofunikira pakulipira.
• Tsegulani singano pochotsa kapu.
• Konzani khungu.
• Ikani singano yonse pansi pa khungu. Kukwaniritsa mfundoyi, muyenera kusamala kuti musalowe muzombo.
• Tsopano muyenera kukanikiza batani, gwiritsitsani.
• Yembekezerani chizindikirocho kuti mutsirize kukonzekera kwa mankhwalawo kuti mumveke, werengani masekondi 10. ndi kutulutsa syringe. Onetsetsani kuti mlingo wosankhidwa ukuperekedwa kwathunthu.
• Ikani chimbale cha zidakwa pamalowo a jakisoni. Mulimonsemo muyenera kukanikiza, kupukuta kapena kupukusa malo a jekeseni.
• Tsekani singano ndi kapu yoteteza.

Mukamagwiritsa ntchito mankhwalawa, muyenera kudziwa kuti zinthu zomwe zimagwiritsidwa ntchito pabokosi liyenera kuzitenthetsa m'manja musanagwiritse ntchito chipinda. Kumayambiriro pansi pakhungu la mankhwalawa ndi cholembera kumachitika mu ntchafu, phewa, pamimba kapena matako. Ndikupangiratu kuti musapange jekeseni malo omwewo. Gawo la thupi lomwe insulin imalowetsedwa mwezi uliwonse liyenera kusinthidwa. Gwiritsani ntchito Humalog pokhapokha mutayezera shuga kuti mupewe zovuta.

Kuti tichotse matenda a shuga m'mankhwala, ndimakonda kugwiritsa ntchito insulin analogues.

Popita nthawi, mankhwalawa akuchulukirachulukira pakati pa madokotala ndi odwala awo.

Izi zitha kufotokozedwanso:

• zokwanira bwino za insulini popanga mafakitale,
• mbiri yayikulu chitetezo,
• kugwiritsa ntchito mosavuta
• kutengera kulumikizira jakisoni wa mankhwala ndi chinsinsi chake cha mahomoni.

Pakapita kanthawi, odwala omwe ali ndi matenda a shuga 2 amakakamizidwa kuti asinthe mapiritsi ochepetsa shuga m'magazi kuti alowe jakisoni wa insulin. Chifukwa chake, funso loti musankhe mankhwalawa ndiwofunika kwambiri.

Anafananizira motchipa Humalog

Mukamawerengera mtengo wake zotchipa zotchedwa Humalog mtengo wocheperako womwe umapezeka mumndandanda wamapulogalamu omwe amaperekedwa ndi ma pharmacies adaganiziridwa

Ma analogues odziwika

Popeza mndandanda wamankhwala osokoneza bongo kutengera manambala a mankhwala omwe apemphedwa kwambiri

Analogs mwa chisonyezo ndi njira yogwiritsira ntchito

Kuphatikizika kosiyanasiyana, kungagwirizane mukuwonetsa komanso momwe mungagwiritsire ntchito

Kupanga mndandanda wamtengo wotsika mtengo wa mankhwala okwera mtengo, timagwiritsa ntchito mitengo yomwe imatipatsa mankhwala opitilira 10,000 mu Russia yonse. Dongosolo losungirako zamankhwala ndi mawonekedwe awo limasinthidwa tsiku ndi tsiku, chifukwa chake zambiri zomwe zimaperekedwa patsamba lathu zimangokhala zatsopano monga lero. Ngati simunapeze analogue yosangalatsa kwa inu, chonde gwiritsani ntchito kusaka pamwambapa ndikusankheni mankhwala osangalatsa kuchokera pamndandanda. Patsamba lililonse la iwo mupeza zosankha zonse za mankhwala omwe mungafune, komanso mitengo ndi ma adilesi omwe amapezekamo.

Malangizo a Humalog

kuyimitsidwa koyenda

Kusakaniza kwa lyspro insulin - kukonzekera insulin mwachangu komanso kuyimitsidwa kwa protamine kuyimitsidwa kwa lyspro insulin - kukonzekera kwa insulini pakukonzekera. Lyspro insulin ndi michere ya DNA yophatikizananso ndi insulin ya anthu; Imayendetsa kagayidwe ka glucose, imakhala ndi zotsatira za anabolic. Mu minofu ndi minyewa ina (kupatula bongo) imathandizira kusintha kwa glucose ndi amino acid kulowa mu khungu, imalimbikitsa kupangika kwa glycogen kuchokera ku glucose m'chiwindi, kupondereza gluconeogeneis ndikuwonjezera kutembenuka kwa glucose ochulukirapo kukhala mafuta. Zofanana ndi insulin yaumunthu. Poyerekeza ndi insulin yaumunthu yokhazikika, imadziwika ndi kuyamba mwachangu, kuyambika koyambirira kwa kanthu komanso nthawi yayifupi ya hypoglycemic zochita (mpaka maola 5). Kuyambanso mwachangu (mphindi 15 pambuyo pa kupangika) kumalumikizidwa ndi kuthamanga kwambiri ndipo kumalola kuti liperekedwe nthawi yomweyo musanadye (15 maminiti) - insulin yaumunthu yokhazikika imaperekedwa mphindi 30. Kusankha kwa jakisoni wambiri ndi zinthu zina kungakhudze kuchuluka kwa mayamwidwe ndi kuyamba kwake. Kuchuluka kwake kumawonedwa pakati pa maola 0.5 ndi 2,5, kutalika kwa nthawi ndi maola 3-4.

Type 1 shuga mellitus, makamaka ndi tsankho la ma insulin ena, postprandial hyperglycemia yomwe singathe kuwongoleredwa ndi ma insulin ena: kuthana kwambiri kwa insulini kukana (kuthamangitsa kuchepa kwa insulin). Type 2 shuga mellitus - mu milandu kukana m`kamwa hypoglycemic mankhwala, kuphwanya mayamwidwe ena insulin, pa ntchito, matenda wamba.

Hypersensitivity, hypoglycemia, insulinoma.

Thupi lawo siligwirizana (urticaria, angioedema - malungo, kufupika, kuchepa kwa magazi), lipodystrophy, zolakwika zosakhalitsa (nthawi zambiri mwa odwala omwe sanalandire insulin kale), hypoglycemia, hypoglycemic coma. Zizindikiro: ulesi, thukuta, thukuta lotupa, tachycardia, kunjenjemera, njala, nkhawa, paresthesias mkamwa, kutsekemera kwa khungu, kupweteka mutu, kunjenjemera, kusanza, kugona, kugona tulo, mantha, kuthedwa nzeru, kukwiya, zachilendo, kusatsika koyenda, kusalankhula bwino ndi masomphenya, chisokonezo, chikomokere, kukomoka.Chithandizo: ngati wodwalayo akudziwa, dextrose amalembedwa pakamwa, s / c, iv kapena iv pakamwa jekeseni kapena iv hypertonic dextrose solution. Ndikupanga chikomokere cha hypoglycemic, 20-40 ml (mpaka 100 ml) wa 40% dextrose solution amawayilowetsa mu mtsinje mpaka wodwala atatuluka.

Mlingo ndi makonzedwe:

Mlingo umatsimikiziridwa payekha kutengera mulingo wa glycemia. Kusakaniza kwa 25% insulin lispro ndi 75% kuyimitsidwa kwa protamine kuyenera kuperekedwa kokha s / c, nthawi zambiri mphindi 15 musanadye. Ngati ndi kotheka, mutha kulowa limodzi ndi insulin yokonzekera nthawi yayitali kapena ndi sulfonylureas pakamwa. Majakisoni amayenera kupangidwa m'ma s, mapewa, matako, matumbo. Masamba a jakisoni ayenera kusinthidwa kuti malo omwewo asagwiritsidwerenso nthawi 1 pamwezi. Ndi s / c makonzedwe, chisamaliro chimayenera kutengedwa kuti musalowe mumtsempha wamagazi. Odwala omwe ali ndi vuto laimpso komanso / kapena chiwindi, kuchuluka kwa insulin yozungulira, kumakulirakulira, ndipo kufunika kwake kumachepetsedwa, komwe kumafunikira kuwunika mosamala kuchuluka kwa glycemia ndi kusintha kwa insulin.

Njira yoyendetsera njira yomwe ikugwiritsidwa ntchito ikuyenera kuonedwa bwino. Posamutsa odwala kuchokera ku insulin yomwe ikuyenda mwachangu kuchokera ku insulin lispro, kusintha kwakufunikira kungafunike. Kusamutsidwa kwa odwala omwe amalandira insulin tsiku lililonse kuposa 100 IU kuchokera ku mtundu umodzi wa insulin kupita kwa ena ndikulimbikitsidwa kuti ikuchitika kuchipatala. Kufunika kwa insulin kumatha kuwonjezeka panthawi yomwe matenda opatsirana, ndi nkhawa zam'maganizo, ndi kuchuluka kwa chakudya chamagulu ambiri, pakudya kowonjezereka kwa mankhwala omwe ali ndi vuto la hyperglycemic (mahomoni a chithokomiro, GCS, kulera kwapakamwa, thiazide diuretics). Kufunika kwa insulin kumatha kuchepa ndi kuchepa kwaimpso komanso / kapena chiwindi, ndi kuchepa kwa kuchuluka kwa chakudya chamagulu m'zakudya, kuwonjezera kuchuluka kwa thupi, panthawi yowonjezera ya mankhwala omwe ali ndi vuto la hypoglycemic (Mao inhibitors, osasankha beta-blockers, sulfonamides). Chizolowezi chokhala ndi hypoglycemia chimatha kuvulaza kuthekera kwa odwala kutenga nawo mbali mokwanira mumsewu, komanso kukonza makina ndi zida zake. Odwala omwe ali ndi matenda ashuga amatha kuyimitsa pang'ono hypoglycemia yomwe amamva pakudya shuga kapena zakudya zopatsa thanzi (tikulimbikitsidwa kuti nthawi zonse muzikhala ndi shuga osachepera 20 g). Ndikofunikira kudziwitsa adokotala za hypoglycemia yomwe yasamutsidwa kuti athetse vuto la kufunika kwa kukonza mankhwalawa. Kufunika kwa insulin nthawi zambiri kumachepera mu trimester yoyamba ya kutenga pakati ndikuwonjezeka kwachiwiri mpaka kwachitatu trimesters. Panthawi yobereka komanso pambuyo pawo, kufunika kwa insulin kumatha kuchepa kwambiri.

Chidziwitso chonse chimaperekedwa pofuna kudziwa zambiri osati chifukwa chodzipangira nokha kapena kusintha mankhwala.

Yankho la iv and sc management zowonekera, zopanda utoto.

Othandizira: glycerol (glycerin) - 16 mg, metacresol - 3.15 mg, zinc oxide (q.s. pazinthu Zn 2+ 0.0197 mcg), sodium hydrogen phosphate heptahydrate - 1.88 mg, hydrochloric acid solution 10% ndi / kapena sodium hydroxide solution 10% - q.s. mpaka pH 7.0-8.0, madzi d / i - q.s. mpaka 1 ml.

3 ml - makatoni (5) - matuza (1) - mapaketi a makatoni.
3 ml - makatoni omwe adapangidwa mu cholembera cha syringe cha QuickPen ™ (5) - makatoni.

Kufotokozera kwa mankhwalawa kumadalira malangizo omwe amagwiritsidwa ntchito kuti avomereze ndikuvomerezedwa ndi wopanga.

Pharmacokinetics

Zogulitsa ndi kugawa

Pambuyo pa utsogoleri wa sc, insulin lyspro imalowetsedwa mwachangu ndikufika ku max m'magazi pambuyo pa mphindi 30-70. V d wa lyspro insulin ndi insulin wamba ya anthu onse ndi ofanana ndipo ali m'malo osiyanasiyana 0,26-0.36 l / kg.

Ndi s / c makonzedwe a T 1/2 a insulin, lispro ili pafupifupi ola limodzi.Odwala aimpso ndi hepatic kusowa, kuchuluka kwa mayamwa lyspro kumakhalabe kuyerekezera ndi wamba insulin.

- shuga mellitus mwa akulu ndi ana, omwe amafunikira chithandizo cha insulin kuti akhalebe ndi shuga.

Mlingo

Dokotala amatsimikiza za mankhwalawo payekha, kutengera zosowa za wodwalayo. Humalog ® imatha kuperekedweratu chakudya chisanafike, ngati kuli kofunikira mukangomaliza kudya.

Kutentha kwa mankhwala omwe amaperekedwa kuyenera kukhala kutentha kwambiri.

Humalog ® imayendetsedwa s / c munjira ya jakisoni kapena mwanjira yowonjezera ya s / c pogwiritsa ntchito pampu ya insulin. Ngati ndi kotheka (ketoacidosis, matenda apakatikati, nthawi pakati pa ntchito kapena nthawi ya postoperative) Humalog ® ikhoza kulowa mkati / mkati.

SC iyenera kuperekedwa kwa phewa, ntchafu, matako, kapena pamimba. Masamba a jakisoni ayenera kusinthidwa kuti malo omwewo asagwiritsidwerenso nthawi 1 pamwezi. Mukamapereka mankhwala a Humalog ® pakukhazikitsa, chisamaliro chiyenera kutengedwa kuti mupewe mankhwalawo m'mitsempha yamagazi. Pambuyo pa jakisoni, tsamba la jakisidwe siliyenera kutenthedwa. Wodwala ayenera kuphunzitsidwa njira yolondola ya jakisoni.

Malangizo a kukhazikitsidwa kwa mankhwalawa Humalog ®

Kukonzekera mawu oyamba

Mankhwala othandiza Humalog ® ayenera kukhala owonekera komanso opanda khungu. Njira yothira ngati yafinya, kapena yakuwala pang'ono ya mankhwalawo, kapena ngati tinthu tating'onoting'ono tapezeka m'maso, sitiyenera kugwiritsidwa ntchito.

Mukakhazikitsa cartridge mu syringe cholembera (cholembera), ndikulowa ndi singano ndikuchita jakisoni wa insulin, ndikofunikira kutsatira malangizo a wopanga omwe amaphatikizidwa ndi cholembera chilichonse.

2. Sankhani tsamba la jakisoni.

3. Antiseptic kuchitira khungu malo jakisoni.

4. Chotsani kapu ku singano.

5. Sinthani khungu lanu mwakuutambasula kapena poteteza khola lalikulu. Ikani singano molingana ndi malangizo ogwiritsa ntchito cholembera.

6. Kanikizani batani.

7. Chotsani singano ndikufinya pang'onopang'ono malo a jakisoni kwa masekondi angapo. Osatupa malo a jakisoni.

8. Pogwiritsa ntchito singano, inaninso singano ndikuwononga.

9. Mawebusayiti ayenera kusinthidwa kuti malo omwewo asagwiritsenso ntchito nthawi 1 pamwezi.

I kuyang'anira insulin

Jekeseni wa intravenous wa Humalog ® uyenera kuchitika molingana ndi chizolowezi chachipatala cha jakisoni wamkati, mwachitsanzo, kulowetsedwa kwa bolus kapena kugwiritsa ntchito njira yolowetsera. Poterepa, nthawi zambiri ndikofunikira kulamula kuchuluka kwa shuga m'magazi.

Makina a kulowetsedwa okhala ndi zozungulira kuyambira 0,1 IU / ml mpaka 1,0 IU / ml insulin lispro mu 0,9% sodium chloride solution kapena 5% dextrose solution amakhala okhazikika firiji kwa maola 48.

Kulowetsedwa kwa insulin / P / C pogwiritsa ntchito pampu ya insulin

Potengera kulowetsedwa kwa Humalog ®, mapampu Ochepera ndi Disetronic amatha kugwiritsa ntchito kulowetsedwa kwa insulin. Muyenera kutsatira mosamalitsa malangizo omwe abwera ndi pampu. Njira ya kulowetsedwa imasinthidwa maola 48 aliwonse. Pakachitika vuto la hypoglycemic, kulowetsaku kumayimitsidwa mpaka gawo litatsimikiza. Ngati pali shuga wobwereza mobwerezabwereza kapena wochepa kwambiri m'magazi, ndiye kuti muyenera kudziwitsa dokotala za izi ndikuganiza kuchepetsa kapena kuletsa kulowetsedwa kwa insulin. Kuperewera kwa pampu kapena kufalikira mu dongosolo la kulowetsedwa kumatha kubweretsa kukwera msanga kwamagazi. Ngati mukukayikira kuti akuphwanya insulin, muyenera kutsatira malangizowo ndipo ngati kuli koyenera dziwitsani adokotala. Mukamagwiritsa ntchito pampu, kukonzekera kwa Humalog ® sikuyenera kusakanikirana ndi ma insulini ena.

Zotsatira zoyipa

Zotsatira zoyipa zomwe zimapezeka ndi mankhwala: hypoglycemia. Hypoglycemia yayikulu imatha kutha mphamvu ya chikumbumtima (hypoglycemic chikomokere), ndipo, mwatsatanetsatane, kufa.

Zotsatira zoyipa: thupi lawo siligwirizana angathe - redness, kutupa kapena kuyabwa pa jakisoni jekeseni (nthawi zambiri zimatha patadutsa masiku angapo kapena masabata), zokhudza zonse zomwe zimachitika (zimachitika kangapo, koma zimakhala zowopsa) - kuyabwa kwambiri, urticaria, angioedema, kutentha thupi, kufupika, kuchepa HELL, tachycardia, kuchuluka thukuta. Milandu yambiri yokhudzana ndimomwe thupi limagwirira ntchito ikhoza kukhala pachiwopsezo cha moyo.

Zomwe zimachitika: lipodystrophy pamalo a jekeseni.

Mimba komanso kuyamwa

Mpaka pano, palibe zotsatira zosasangalatsa za Lyspro insulin pa mimba kapena thanzi la mwana wosabadwayo / wakhanda. Palibe kafukufuku wokhudzana ndi mliri omwe adachitika.

Cholinga cha mankhwala a insulin panthawi yapakati ndikusunga chiwonetsero chokwanira cha kuchuluka kwa shuga mwa odwala omwe ali ndi matenda a shuga a shuga komanso omwe ali ndi matenda a shuga. Kufunika kwa insulin nthawi zambiri kumachepera mu trimester yoyamba ndikuwonjezeka muyezo wachiwiri ndi wachitatu wama trimesters apakati. Nthawi yobadwa pambuyo pokhapokha ndipo mwayamba kubadwa, zofunika za insulin zimatha kugwa kwambiri.

Akazi azaka zaubala Anthu omwe ali ndi matenda ashuga ayenera kudziwitsa dokotala za mimba yomwe akukonzekera kapena yomwe ikukonzekera. Pa nthawi yoyembekezera, odwala matenda a shuga amafunika kuwunika mosamala kuchuluka kwa shuga m'magazi, komanso kuyang'aniridwa kawirikawiri kuchipatala.

Odwala omwe ali ndi matenda a shuga mellitus nthawi yoyamwitsa, kusintha kwa insulin ndi / kapena zakudya kungafunike.

Bongo

Zizindikiro hypoglycemia, limodzi ndi zizindikiro zotsatirazi: ulesi, kuchuluka thukuta, tachycardia, mutu, kusanza, chisokonezo.

Chithandizo: Hypoglycemia yofewa nthawi zambiri imayimitsidwa ndi kulowerera kwa shuga kapena shuga wina, kapena zinthu zomwe zimakhala ndi shuga.

Kuwongolera kwa hypoglycemia moyenera kumatha kuchitika mothandizidwa ndi / m kapena s / c kukhudzana ndi glucagon, kenako kutsekeka kwa chakudya chamagulu pambuyo pakhazikika pakudwala. Odwala omwe samalabadira glucagon amapatsidwa njira ya iv dextrose (glucose).

Wodwala akakhala kuti akomoka, ndiye kuti glucagon uyenera kutumikiridwa / m kapena s / c. Pokhapokha glucagon kapena ngati palibe chochita ndi kayendetsedwe kake, ndikofunikira kuyambitsa yankho la dextrose (glucose). Atangozindikira, wodwalayo ayenera kupatsidwa chakudya chopatsa thanzi.

Zakudya zowonjezera zowonjezera zamafuta othandizira ndikuwunikira odwala zingafunike, popeza kuyambiranso kwa hypoglycemia ndikotheka.

Apidra SoloStar malangizo ogwiritsira ntchito

• Wopanga
• Dziko lomwe adachokera
• Gulu Gulu
• Kufotokozera
• Kutulutsa Mafomu
• Kufotokozera za mtundu wa kipimo
• Zotsatira za pharmacological
• Pharmacokinetics
• Mikhalidwe yapadera
• Kupanga
• Zizindikiro za Apidra SoloStar zogwiritsidwa ntchito
• Contraindication
• Mlingo
• Zotsatira zoyipa
• Kuyanjana kwa mankhwala
• Bongo
• Malo osungira

Migwirizano ndi magwiritsidwe akusungidwa

Mndandanda B. Mankhwalawa amayenera kusungidwa kuti ana asawafikire, mufiriji, kutentha kwa 2 ° mpaka 8 ° C, osazizira. Moyo wa alumali ndi zaka 2.

Mankhwala omwe amagwiritsidwa ntchito akuyenera kusungidwa kutentha 15th mpaka 25 ° C, otetezedwa ku dzuwa kapena kutentha mwachindunji Moyo wa alumali - osaposa masiku 28.

Pharmacological kanthu Humalog

DNA imabweretsanso insulin. Amasiyana ndi omaliza mwanjira zotsatizana za amino acid pamalo 28 ndi 29 a insulin B.

Choyambitsa chachikulu cha mankhwalawa ndi kuyamwa kwa kagayidwe kazakudya. Kuphatikiza apo, ili ndi anabolic zotsatira. Mu minofu ya minofu, pali kuchuluka kwa glycogen, mafuta acid, glycerol, kuchuluka kwa mapuloteni komanso kuwonjezereka kwa kumwa ma amino acid, koma nthawi yomweyo kumachepa mu glycogenolysis, gluconeogeneis, ketogeneis, lipolysis, proteinabolism ndi kutulutsidwa kwa ma amino acid.

Odwala omwe ali ndi mtundu woyamba wa 2 ndi mtundu wa 2 shuga, akamagwiritsa ntchito insulin lyspro, hyperglycemia yomwe imachitika chakudya itatha amachepetsa kwambiri poyerekeza ndi insulin yaumunthu. Kwa odwala omwe amalandira ma insulin achidule komanso ofunika, amafunika kusankha kuchuluka kwa ma insulin onse kuti tsiku lililonse azikhala ndi shuga.

Monga momwe akukonzekera insulin yonse, kutalika kwa nthawi ya lyspro insulin kumatha kukhala kosiyanasiyana mwa odwala kapena nthawi zosiyanasiyana wodwala yemweyo ndipo zimatengera mlingo, malo a jakisoni, magazi, kutentha kwa thupi ndi zochitika zolimbitsa thupi.

Mankhwala a lyspro insulin mwa ana ndi achinyamata ali ofanana ndi omwe amawonekera mwa akulu.

Odwala omwe ali ndi matenda a shuga a mtundu wachiwiri amalandila Mlingo wambiri wa sulfonylurea, kuwonjezera kwa insulin kumapangitsa kutsika kwa hemoglobin wa glycosylated.

Mankhwala a Lyspro insulin kwa odwala omwe ali ndi matenda amtundu wa 2 ndi mtundu wa 2 amaphatikizidwa ndi kuchepa kwa ziwonetsero za nocturnal hypoglycemia.

Kuyankha kwa glucodynamic ku isulin lispro sikudalira kugwira ntchito kwa impso kapena chiwindi.

Zinawonetsedwa kuti insulin lyspro imakhala yofanana ndi insulin yaumunthu, koma zochita zake zimachitika mwachangu ndipo zimatha kwakanthawi.

Lyspro insulin imadziwika ndi kuyamba mwachangu (pafupifupi mphindi 15), monga Ili ndi mayamwidwe ambiri, ndipo izi zimakupatsani mwayi woti mulowe musanadye (0-15 mphindi musanadye), mosiyana ndi insulin yachilendo (mphindi 30-45 musanadye). Lyspro insulin imakhala ndi nthawi yofupikirako (maola 2 mpaka 5) poyerekeza ndi insulin yaumunthu wamba.

Mlingo ndi njira ya mankhwala.

Dokotala amatsimikiza za mankhwalawo payekha, kutengera zosowa za wodwalayo. Humalog imatha kuperekedweratu musanadye, ngati kuli kotheka - mutangodya.

Kutentha kwa mankhwala omwe amaperekedwa kuyenera kukhala kutentha kwambiri.

Humalog imayendetsedwa sc m'njira ya jakisoni kapena mawonekedwe a sc kulowetsedwa pogwiritsa ntchito insulin pump. Ngati ndi kotheka (ketoacidosis, matenda owopsa, nthawi pakati pa opaleshoni kapena nthawi ya postoperative) Humalog ikhoza kulowa mkati / mkati.

SC iyenera kuperekedwa kwa phewa, ntchafu, matako, kapena pamimba. Masamba a jakisoni ayenera kusinthidwa kuti malo omwewo asagwiritsidwerenso nthawi 1 pamwezi. Mukamayambitsa mankhwalawa Humalog, chisamaliro chiyenera kutengedwa kuti mupewe magazi. Pambuyo pa jakisoni, tsamba la jakisidwe siliyenera kutenthedwa. Wodwala ayenera kuphunzitsidwa njira yolondola ya jakisoni.

Malangizo oyendetsera mankhwalawa Humalog

Kukonzekera mawu oyamba

Yankho la mankhwalawa Humalog liyenera kukhala loonekera komanso lopanda utoto. Njira yothira ngati yafinya, kapena yakuwala pang'ono ya mankhwalawo, kapena ngati tinthu tating'onoting'ono tapezeka m'maso, sitiyenera kugwiritsidwa ntchito.

Mukakhazikitsa cartridge mu syringe cholembera (cholembera), ndikulowa ndi singano ndikuchita jakisoni wa insulin, ndikofunikira kutsatira malangizo a wopanga omwe amaphatikizidwa ndi cholembera chilichonse.

2. Sankhani tsamba la jakisoni.

3. Antiseptic kuchitira khungu malo jakisoni.

4. Chotsani kapu ku singano.

5. Sinthani khungu lanu mwakuutambasula kapena poteteza khola lalikulu. Ikani singano molingana ndi malangizo ogwiritsa ntchito cholembera.

6. Kanikizani batani.

7. Chotsani singano ndikufinya pang'onopang'ono malo a jakisoni kwa masekondi angapo. Osatupa malo a jakisoni.

8. Pogwiritsa ntchito singano, inaninso singano ndikuwononga.

9. Mawebusayiti ayenera kusinthidwa kuti malo omwewo asagwiritsenso ntchito nthawi 1 pamwezi.

I kuyang'anira insulin

Jekeseni wa intravenous wa Humalog uyenera kuchitika molingana ndi chizolowezi chachipatala cha jakisoni wamkati, mwachitsanzo, kulowetsedwa kwa bolus kapena kugwiritsa ntchito kulowetsedwa. Poterepa, nthawi zambiri ndikofunikira kulamula kuchuluka kwa shuga m'magazi.

Makina a kulowetsedwa okhala ndi zozungulira kuyambira 0,1 IU / ml mpaka 1,0 IU / ml insulin lispro mu 0,9% sodium chloride solution kapena 5% dextrose solution amakhala okhazikika firiji kwa maola 48.

Kulowetsedwa kwa insulin / P / C pogwiritsa ntchito pampu ya insulin

Pobayira mankhwala a Humalog, mapampu Ochepera ndi Disetronic angagwiritsidwe ntchito kulowetsedwa kwa insulin. Muyenera kutsatira mosamalitsa malangizo omwe abwera ndi pampu. Njira ya kulowetsedwa imasinthidwa maola 48 aliwonse. Pakachitika vuto la hypoglycemic, kulowetsaku kumayimitsidwa mpaka gawo litatsimikiza. Ngati pali shuga wobwereza mobwerezabwereza kapena wochepa kwambiri m'magazi, ndiye kuti muyenera kudziwitsa dokotala za izi ndikuganiza kuchepetsa kapena kuletsa kulowetsedwa kwa insulin. Kuperewera kwa pampu kapena kufalikira mu dongosolo la kulowetsedwa kumatha kubweretsa kukwera msanga kwamagazi. Ngati mukukayikira kuti akuphwanya insulin, muyenera kutsatira malangizowo ndipo ngati kuli koyenera dziwitsani adokotala. Mukamagwiritsa ntchito pampu, mankhwala a Humalog sayenera kusakanikirana ndi ma insulini ena.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere.

Mpaka pano, palibe zotsatira zosasangalatsa za Lyspro insulin pa mimba kapena thanzi la mwana wosabadwayo / wakhanda. Palibe kafukufuku wokhudzana ndi mliri omwe adachitika.

Cholinga cha mankhwala a insulin panthawi yapakati ndikusunga chiwonetsero chokwanira cha kuchuluka kwa shuga mwa odwala omwe ali ndi matenda a shuga a shuga komanso omwe ali ndi matenda a shuga. Kufunika kwa insulin nthawi zambiri kumachepera mu trimester yoyamba ndikuwonjezeka muyezo wachiwiri ndi wachitatu wama trimesters apakati. Nthawi yobadwa pambuyo pokhapokha ndipo mwayamba kubadwa, zofunika za insulin zimatha kugwa kwambiri.

Amayi amisinkhu yokhala ndi matenda ashuga ayenera kudziwitsa adotolo za kuyambika kapena kukhala ndi pakati. Pa nthawi yoyembekezera, odwala matenda a shuga amafunika kuwunika mosamala kuchuluka kwa shuga m'magazi, komanso kuyang'aniridwa kawirikawiri kuchipatala.

Odwala omwe ali ndi matenda a shuga mellitus nthawi yoyamwitsa, kusintha kwa insulin ndi / kapena zakudya kungafunike.

Malangizo apadera ogwiritsira ntchito Humalog.

Kusamutsa wodwala kupita ku mtundu wina kapena mtundu wa insulin kuyenera kuchitika moyang'aniridwa ndi achipatala. Kusintha kwa zochitika, mtundu (wopanga), mtundu (mwachizolowezi, NPH, Tape), mitundu (nyama, anthu, ma insulin analogue) ndi / kapena njira yopanga (kubwerezanso DNA insulin kapena insulin ya nyama) kungafunike kusintha kwa mlingo.

Mikhalidwe yomwe zizindikiro zoyambirira za hypoglycemia zitha kukhala zopanda tanthauzo komanso zocheperako zimaphatikizira matenda a shuga, kupatsirana kwa insulin, matenda amanjenje matenda a shuga, kapena mankhwala, monga beta-blockers.

Odwala omwe ali ndi vuto la hypoglycemic atasamutsidwa kuchokera ku insulin yochokera ku nyama kupita ku insulin yaumunthu, zizindikiro zoyambirira za hypoglycemia zitha kutchulidwa pang'ono kapena zosiyana ndi zomwe adakumana nazo kale ndi insulin. Hypoglycemic yosasinthika kapena ma hyperglycemic zomwe zimachitika zimatha kuyambitsa chikumbumtima, chikomokere, kapena kufa.

Mlingo wosakwanira kapena kusiya kulandira chithandizo, makamaka ndi matenda a shuga a shuga.

Kufunika kwa insulin kumatha kuchepa kwa odwala omwe amalephera kupweteka kwa impso, komanso kwa odwala omwe ali ndi vuto la chiwindi chifukwa kuchepa kwa gluconeogeneis ndi insulin metabolism. Komabe, mwa odwala omwe ali ndi vuto losatha la chiwindi, kukana kwa insulini kungayambitse kuchuluka kwa insulin.

Kufunika kwa insulin kumatha kuwonjezeka ndi matenda opatsirana, kupsinjika kwamalingaliro, ndikuwonjezereka kwa kuchuluka kwa chakudya chamagulu muzakudya.

Kusintha kwa mlingo kungafunikenso ngati wodwala akucita zolimbitsa thupi kapena ngati zakudya zabwinobwino zasintha. Kuchita masewera olimbitsa thupi mukangomaliza kudya kumawonjezera chiopsezo cha hypoglycemia. Zotsatira za pharmacodynamics za insulin analogi zomwe zimagwira mwachangu ndikuti ngati hypoglycemia imayamba, ndiye kuti imatha kupanga jekeseni m'mbuyomu kuposa kubayidwa insulin yamunthu.

Wodwalayo ayenera kuchenjezedwa kuti ngati dokotala atayambitsa kukonzekera kwa insulin ndi kuchuluka kwa 40 IU / ml mu vial, ndiye kuti insulini sayenera kutengedwa kuchokera ku cartridge ndi insulin ya 100 IU / ml ndi syringe ya jekeseni wa insulin wochita ndi 40 IU / ml.

Ngati kuli kofunikira kumwa mankhwala ena nthawi imodzi ndi Humalog, wodwalayo ayenera kufunsa dokotala.

Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu

Ndi hypoglycemia kapena hyperglycemia yolumikizana ndi mtundu wosakwanira wa dosing, kuphwanya kuthekera kwambiri komanso kuthamanga kwa zochitika zama psychomotor ndikotheka. Izi zitha kukhala pachiwopsezo cha zinthu zoopsa (kuphatikizapo kuyendetsa galimoto kapena kugwira ntchito ndi makina).

Odwala ayenera kusamala kuti apewe hypolycemia poyendetsa. Izi ndizofunikira kwambiri kwa odwala omwe ali ndi kuchepetsedwa kapena kusamvetseka kwa zizindikiro zoneneratu za hypoglycemia, kapena omwe zochitika za hypoglycemia ndizofala. Pazochitika izi, ndikofunikira kuyesa kuwongolera kutha kuyendetsa. Odwala omwe ali ndi matenda ashuga amatha kudzithandizira kuti amvetsetse Hypoglycemia wodwala ngati atenga glucose kapena zakudya zamafuta ambiri (tikulimbikitsidwa kuti nthawi zonse mumakhala ndi shuga g 20%). Wodwala ayenera kudziwitsa adokotala za hypoglycemia yomwe idasamutsidwa.

Kuyanjana kwa Humalog ndi mankhwala ena.

Mphamvu ya Humalog's hypoglycemic imachepetsedwa ndi kulera kwapakamwa, corticosteroids, kukonzekera kwa mahomoni a chithokomiro, danazol, beta2-adrenergic agonists (kuphatikizapo rhytodrin, salbutamol, terbutaline), tricyclic antidepressants, thiazide diuretics, chlorprotixenic acid, chlorprotixenic acid, chlorprotixenic acid zotumphukira za phenothiazine.

Zotsatira za hypoglycemic za Humalog zimapangidwira ndi ophatikiza ndi beta, ma ethanol ndi mankhwala okhala ndi ethanol, anabolic steroids, fenfluramine, guanethidine, tetracyclines, mankhwala apakamwa a hypoglycemic, salicylates (mwachitsanzo, acetylsalicylic acid, aniloprilactyl antagonists, MAP inhibitors, angiotensin II zolandila.

Humalog sayenera kusakanikirana ndi kukonzekera kwa insulin ya nyama.

Humalog ikhoza kugwiritsidwa ntchito (kuyang'aniridwa ndi dokotala) kuphatikiza ndi insulin yaumunthu yotalika kapena kuphatikizidwa ndi othandizira a hypoglycemic, zotumphukira za sulfonylurea.

Migwirizano yosunga mankhwalawa Humalog.

Mndandanda B. Mankhwalawa amayenera kusungidwa kuti ana asawafikire, mufiriji, kutentha kwa 2 ° mpaka 8 ° C, osazizira. Moyo wa alumali ndi zaka 2.

Mankhwala omwe amagwiritsidwa ntchito akuyenera kusungidwa kutentha 15th mpaka 25 ° C, otetezedwa ku dzuwa kapena kutentha mwachindunji Moyo wa alumali - osaposa masiku 28.

• Njira yothetsera vutoli ndi yopanda utoto, yowonekera m'makatoreji atatu a 3 ml mu paketi yonyamula m'makatoni olemba No.
• Katoni yomwe ili mu cholembera cha syringe ya QuickPen (5) ili pabokosi la makatoni.
• Humalog Remix 50 ndi Humalog Mix 25 ikupezekanso.Insulin Humalog Remix ndi msanganizo wofanana wofanana ndi Lizpro yochepa-insulin solution ndi Lizpro insulin kuyimitsidwa ndi nthawi yayitali.

Mankhwala

Insulin Humalog ndi DNA yosinthika ya insulin ya anthu. Chochititsa chidwi ndi kusintha kwa kuphatikiza kwa ma amino acid mu insulin B.

Mankhwala amawongolera njirayi shuga kagayidwe ndipo ali nazo anabolic zotsatira. Zilowetsedwa m'matumba a minofu ya anthu, zomwe zimakulirakulira zimachuluka glycerol, glycogenmafuta acids kumathekamapuloteni kaphatikizidwe, kumwa ma amino acid kukukula, komabe, kukuchepa gluconeogenesis, ketogenesis, glycogenolysis, lipolysiskumasulidwa ma amino acidndi catabolism mapuloteni.

Ngati alipo shuga 1ndi2mitundu yandi kumayambiriro kwa mankhwala atatha kudya, kutchulidwa kokwanira hyperglycemiaZokhudza insulin ya munthu. Kutalika kwa Lizpro kumasiyanasiyana ndipo kumatengera zinthu zambiri - mlingo, kutentha kwa thupi, jakisoni, magazi, kuchita masewera olimbitsa thupi.

Makonzedwe a insulin a Lizpro amaphatikizidwa ndi kuchepa kwa ziwonetsero nocturnal hypoglycemia Odwala omwe ali ndi matenda a shuga, ndipo zochita zake poyerekeza ndi insulin ya anthu zimachitika mofulumira (pafupifupi pambuyo mphindi 15) ndipo zimakhala zazifupi (kuyambira maola 2 mpaka 5).

Humalog, malangizo ogwiritsira ntchito

Mlingo wa mankhwalawa umayikidwa payekha kutengera mphamvu ya odwala exo native insulin ndi momwe alili. Ndikulimbikitsidwa kupatsa mankhwala osapitirira mphindi 15 musanadye kapena mutatha kudya. Njira yoyendetsera ntchito ndi payokha. Pochita izi, kutentha kwa mankhwala akhale pamalo oyenera.

Zofunikira zatsiku ndi tsiku zimatha zosiyanasiyana, mpaka nthawi zambiri zimakhala 0.5-1 IU / kg. Mtsogolomo, tsiku ndi tsiku Mlingo umodzi wa mankhwalawo umasinthidwa malinga ndi momwe wodwala amagwirira ntchito ndi zambiri kuchokera ku mayeso angapo a magazi ndi mkodzo wa glucose.

Intravenous management ya Humalog imachitika ngati muyezo wa jekeseni wovomerezeka. Jakisoni wotsekemera amapangidwa m'apewa, matako, ntchafu kapena pamimba, nthawi ndi nthawi kuwasinthana osaloleza kugwiritsa ntchito malo amodzimodzi kamodzi pamwezi, ndipo malo omwe jakisoniyo sayenera kutenthedwa. Pakati pa njirayi, chisamaliro chimayenera kutengedwa kuti musalowe mumtsempha wamagazi.

Wodwala ayenera kuphunzira njira yolondola ya jakisoni.

Chofunikira chachikulu

Mankhwalawa ndi njira yopanda maonekedwe, yopaka makatoni (1.5, 3 ml) kapena mabotolo (10 ml). Imaperekedwa kudzera m'mitsempha. Chithandizo chogwira mankhwalawa ndi insulin lispro, kuchepetsedwa ndi zina zowonjezera.

Zowonjezera zina zikuphatikiza:

1. metacresol
2. glycerol
3. zinc oxide
4. sodium hydrogen phosphate,
5. 10% hydrochloric acid solution,
6. 10% sodium hydroxide solution,
7. madzi osungunuka.

Mankhwala akuphatikizidwa mu kayendedwe ka glucose, pochita zotsatira za anabolic.

Analogs ATC Level 3

Mankhwala opitilira atatu omwe ali ndi mawonekedwe osiyana, koma ofanana ndi mawonekedwe, njira yogwiritsira ntchito.

Mayina a ena ofanana ndi Humalog malinga ndi kuchuluka kwa code ya ATC 3:

• Biosulin N,
• Insuman Bazal,
• Protafan
• Humodar b100r,
• Gensulin N,
• Insugen-N (NPH),
• Protafan NM.

Kusintha kwa Humalog ndi Humalog 50: kusiyana

Ena odwala matenda ashuga molakwika amalingalira kuti mankhwalawa ndi othandizira kwathunthu. Izi siziri choncho. Prostamine Hagedorn (NPH) yosalowerera ndale, yomwe imachepetsa kuchitira insulin, imayambitsidwa mu Kusakaniza kwa Humalog 50 .

Zowonjezera zowonjezera, nthawi yayitali ntchito.Kutchuka kwake pakati pa odwala matenda ashuga ndi chifukwa chakuti imathandizira njira yothandizira mankhwala a insulin.

Humalog Sakanizani ma cartridge 50 100 IU / ml, 3 ml mu syringe ya Quick Pen

Chiwerengero cha tsiku ndi tsiku cha jakisoni chimachepetsedwa, koma izi sizothandiza kwa odwala onse. Ndi jakisoni, nkovuta kupereka njira zabwino zowongolera shuga. Kuphatikiza apo, ndale ya protamine Hagedorn nthawi zambiri imayambitsa zovuta zomwe zimayambitsa matenda ashuga.

Nthawi zambiri, insulin yomwe imakhala nthawi yayitali imaperekedwa kwa odwala okalamba, omwe, chifukwa cha ukalamba, amayiwala kupanga jakisoni panthawi.

Humalog, Novorapid kapena Apidra - ndibwino?

Mitundu yawo yosinthika imapangitsa kuti achepetse shuga mwachangu.

Insulin yaumunthu imayamba kuchita theka la ola, mankhwala ake omwe amafananizidwa ndi zotsatira zake amafunika mphindi 5-15 zokha. Humalog, Novorapid, Apidra ndi mankhwala a ultrashort omwe amapangidwa kuti achepetse shuga.

Mwa mankhwala onse, wamphamvu kwambiri ndi Humalog. . Imachepetsa shuga m'magazi 2,5 kuposeranso insulin yayifupi ya munthu.

Novorapid, Apidra ndiwofooka pang'ono. Ngati mungayerekeze mankhwalawa ndi insulin ya munthu, zimapezeka kuti zimakhala zamphamvu nthawi 1.5 kuposa zotsalazo.

Kupereka mankhwala enaake ochizira matenda a shuga ndi udindo wapadera wa dokotala. Wodwala amakumana ndi ntchito zina zomwe zingamulole kuthana ndi matendawa: kutsatira kwambiri, malingaliro a dokotala, kuchita zotheka.

Makanema okhudzana nawo

Pazakugwiritsa ntchito ka insulin Humalog mu kanema:

DNA imabweretsanso insulin.
Kukonzekera: HUMALOG®
The yogwira mankhwala: insulin lyspro
ATX Encoding: A10AB04
KFG: Insulin yofulumira ya anthu
Nambala yolembetsa: P. 015490/01
Tsiku lolembetsa: 02.02.04
Mwini reg. acc: LILLY FRANCE S.A.S.

Njira yothetsera jakisoni ndi yowonekera, yopanda utoto.

1 ml
insulin lispro *
100 IU

Omwe amathandizira: glycerol, zinc oxide, sodium hydrogen phosphate, m-cresol, madzi d / ndi, hydrochloric acid yankho la 10% ndi sodium hydroxide solution ya 10% (kupanga pH yofunikira).

3 ml - makatoni (5) - matuza (1) - mapaketi a makatoni.

* Dongosolo la mayiko ena omwe siali eni ake omwe amavomerezedwa ndi WHO, ku Russian Federation, matchulidwe a dzina lapadziko lonse - insulin lispro amavomerezedwa.

Kufotokozera kwa mankhwalawa kumatengera malangizo ovomerezeka omwe angagwiritsidwe ntchito.

Apidra SoloStar mavuto

• Hypoglycemia ndiyo njira yosavomerezeka kwambiri ya insulin, yomwe imatha kuchitika ngati mulingo wambiri wa insulin umagwiritsidwa ntchito mopitilira kufunika kwake. Zotsatira zoyipa zomwe zimayesedwa kuchipatala zoyesedwa ndi kuperekera mankhwalawa zalembedwa pansipa molingana ndi machitidwe a ziwalo komanso dongosolo loti muchepe. Mukamafotokozera pafupipafupi zomwe zimachitika, njira zotsatirazi zimagwiritsidwa ntchito: nthawi zambiri -> 10%, nthawi zambiri -> 1% ndi 0,1% ndi 0,01% komanso mogwirizana ndi Mankhwala

Kafukufuku wokhudzana ndi kukhudzana kwa mankhwala a pharmacokinetic kwa mankhwalawa sanachitike. Kutengera ndi kudziwa komwe kumanenedwa ndimankhwala ena ofanana, kuwoneka kwa mgwirizano wachipatala kwambiri sikungachitike. Zinthu zina zimatha kukhudza kagayidwe kakang'ono ka glucose, kamene kangafunike kusintha kwa insulin glulisin makamaka kuwunika mosamala chithandizo ndi momwe wodwalayo alili. Mukagwiritsidwa ntchito limodzi, othandizira pakamwa a hypoglycemic, ma ACE inhibitors, disopyramids, fibrate, fluoxetine, mao inhibitors, pentoxifylline, propoxyphene, salicylates ndi sulfonamide antimicrobials angapangitse mphamvu ya insulin ndikuwonjezera kutanthauzira kwa hypoglycemia.

Mitengo ya Apidra SoloStar m'mizinda inanso

Apidra SoloStar ku Moscow, Apidra SoloStar ku St. Petersburg, Apidra SoloStar ku Novosibirsk, Apidra SoloStar ku Nizhny Novgorod, Apidra SoloStar ku Kazan, Apidra SoloStar ku Chelyabinsk, Apidra SoloStar ku Omsk, Apidar Solara ku Rostov-on-Don, Apidra SoloStar ku Ufa, Apidra SoloStar ku Krasnoyarsk, Apidra SoloStar ku Perm, Apidra SoloStar ku Voronezh, Apidra SoloStar ku Krasnodar, Apidra SoloStar ku Saratov, Apatra, Apid rinburg

Mukamayitanitsa ku Apteka.RU, mutha kusankha kupita ku malo ogulitsa mankhwala omwe muli nawo pafupi ndi nyumba yanu kapena panjira yakunyumba.

Malo onse operekera ku Yekaterinburg - pharmacies 145

Malo onse operekera ku Yekaterinburg
- 145 malo ogulitsa mankhwala

Ndemanga za ntchito Apteka.RU
Malingaliro asanu

A10AB06 Insulin glulisin

Zithunzi za 3D

Mlingo ndi makonzedwe

S / c, posachedwa (0-15 mphindi) asanadye kapena atangomaliza kudya.

Apidra® SoloStar ® iyenera kugwiritsidwa ntchito pazamankhwala omwe amaphatikizapo insulini kapena wochita insulin kwa nthawi yayitali kapena analogue wa insulin wa nthawi yayitali. Kuphatikiza apo, Apidra® SoloStar ® ikhoza kugwiritsidwa ntchito limodzi ndi othandizira pakamwa.

Mlingo wa mankhwalawa Apidra® SoloStar® amasankhidwa payekha.

Apidra® SoloStar ® imayendetsedwa ndi jakisoni wa sc kapena kudzera mwa kulowetsedwa kosalekeza m'mafuta oyenda pogwiritsa ntchito pampu.

Jekeseni wa subcutaneous wa Apidra® SoloStar ® uyenera kuchitidwa m'chigawo cha mpanda wamimba wam'mimba, phewa kapena ntchafu, ndipo mankhwalawa amathandizidwa ndi kulowetsedwa kosalekeza m'mafuta oyambira m'chigawo cha khomo lamkati lakumbuyo. Masamba obayira ndi kulowetsedwa m'malo omwe ali pamwambapa (khoma lakunja lam'mimba, ntchafu kapena phewa) ziyenera kusinthana ndi kukonzekera kulikonse kwatsopano kwa mankhwalawa. Kuchuluka kwa mayamwidwe, motero, kuyambira ndi kutalika kwa zochita zingakhudzidwe ndi: malo oyang'anira, zochitika zolimbitsa thupi ndi zina zosintha. Kuwongolera kwa khoma lam'mimba kumapereka khunyu mwachangu kuposa kayendetsedwe kazinthu zina zatchulidwazi (onani gawo la "Pharmacokinetics").

Chenjezo liyenera kuonedwa kuti mankhwalawo asalowe mwachindunji m'mitsempha ya magazi. Pambuyo pa kukonzekera mankhwalawa, ndizosatheka kutikita minyewa yoyang'anira. Odwala ayenera kuphunzitsidwa njira yolondola ya jakisoni.

Kusakaniza kwa insulin

Apidra® SoloStar ® ikhoza kusakanikirana ndi insulin-isophan yaumunthu.

Mukasakaniza Apidra® SoloStar ® ndi insulin-isophan ya anthu, Apidra® SoloStar® iyenera kukhala yoyamba kukokedwa mu syringe. Kubayidwa kwa SC kuyenera kuchitidwa mukangosakaniza. Osakaniza ma insulin omwe ali pamwambapa sangathe kulowa / kulowa.

Kupukuta kachipangizo kopitiliza kosalekeza

Mukamagwiritsa ntchito Apidra® SoloStar ® ndi pulogalamu yopopera pokonza insulin, singaphatikizidwe ndi mankhwala ena.

Apidra ® ikhoza kutumizidwanso pogwiritsa ntchito chipangizo chopompa popitilira insulin. Ngati ndi kotheka, kukonzekera kwa Apidra® kumatha kuchotsedwa mu katoni ya syringe ya Apidra ® SoloStar ® ndikugwiritsira ntchito makina pogwiritsa ntchito pampu popukutira insulin mosalekeza.

Nthawi yomweyo, kulowetsedwa ndi chosungira chogwiritsidwa ntchito ndi Apidra ® ziyenera kulowedwa m'malo ndi malamulo aseptic pafupifupi maola 48. Malangizo awa akhoza kusiyanasiyana ndi malangizo apomwe akupezeka pakugwiritsa ntchito zida zapompo. Ndikofunika kuti odwala azitsatira malangizo apadera omwe ali pamwambawa kuti agwiritse ntchito Apidra®. Kulephera kutsatira malangizo apaderawa ogwiritsidwa ntchito ndi Apidra® kungapangitse kuti pakhale zochitika zovuta kwambiri.

Mukamagwiritsa ntchito Apidra® ndi chipangizo chothandizira kupomeleza insulini mosalekeza, singathe kusakanikirana ndi ma insulin ena kapena ma sol sol.

Odwala omwe amalandiridwa ndi Apidra ® ndi kulowetsedwa kosalekeza ayenera kukhala ndi njira zina zochitira insulin ndipo ayenera kuphunzitsidwa mu insulin yolandirira jekeseni ya sc (pakavulazidwa chipangizo chomwe chimagwiritsidwa ntchito).

Mukamagwiritsa ntchito Apidra® ndi zida zamapampu zothandizira kulowetsedwa kwa insulin, kusokonezeka kwa chida cha pampu, kusagwira bwino ntchito kwa kulowetsedwa, kapena zolakwika pakugwiritsa ntchito kungayambitse kukula kwa hyperglycemia, ketosis, ndi matenda ashuga a ketoacidosis. Pankhani ya chitukuko cha hyperglycemia kapena ketosis kapena matenda ashuga ketoacidosis, kuzindikiritsa mwachangu ndi kuchotsera zomwe zimayambitsa chitukuko.

Tsatirani malangizo oyenera kugwiritsa ntchito ma syringe amadzaza (onani gawo "Malangizo ogwiritsira ntchito ndi kusamalira").

Malangizo ogwiritsira ntchito ndi kusamalira cholembera chodzaza ndi SoloStar ®

Asanayambe kugwiritsa ntchito, cholembera cha syringe chimasungidwa kutentha kwa firiji kwa maola 1-2.

Musanagwiritse ntchito, yang'anani cartridge mkati mwa cholembera. Iyenera kugwiritsidwa ntchito pokhapokha yankho likakhala lowonekera, lopanda utoto, lilibe tinthu tolimba tomwe timayimira, ndikufanana, madzi.

Ma syringe a Empty SoloStar ® sayenera kugwiritsidwanso ntchito ndipo ayenera kutayidwa.

Popewa matenda, cholembera chodzaza chisanachitike chizingogwiritsidwa ntchito ndi wodwala m'modzi ndipo sayenera kusamutsidwira wina.

Kugwira cholembera SoloStar ® Syringe

Musanagwiritse ntchito cholembera cha SoloStar®, muyenera kuwerenga mosamala malangizo kuti agwiritse ntchito.

Chidziwitso chofunikira pakugwiritsa ntchito SoloStar® Syringe pen

Musanagwiritse ntchito, gwiritsani ntchito singano yatsopano ndi cholembera chonde ndikuyesa mayeso. Ma singano okhawo omwe amagwirizana ndi SoloStar® ndi omwe ayenera kugwiritsidwa ntchito.

Malangizo apadera amayenera kuchitika popewa ngozi zokhudzana ndi kugwiritsa ntchito singano komanso mwayi wopatsira matenda.

Musagwiritse ntchito cholembera cha SoloStar ® ngati chawonongeka kapena ngati mulibe chitsimikizo kuti chidzagwira ntchito moyenera.

Nthawi zonse khalani ndi cholembera cha SoloStar ® chopopera pokhapokha mutataya kapena kuwononga chiyerekezo chanu.

Malangizo osungira

Ngati cholembera cha SoloStar ® chikusungidwa mufiriji, chikuyenera kuchotsedwa pamenepo kwa maola 1-2 musanabaye jekeseni kuti yankho lithe kutentha. Makamaka insulini yodziwika bwino imapweteka kwambiri.

Cholembera cha SoloStar ® Syringe chikuyenera kuwonongeka.

SoloStar® syringe cholembera iyenera kutetezedwa kufumbi ndi fumbi.

Kunja kwa SoloStar® Syringe cholembera kumatha kutsukidwa ndikumupukuta ndi nsalu yonyowa.

Osamiza m'madzimadzi, muzimutsuka ndikudzoza cholembera cha SoloStar ®, chifukwa izi zitha kuwononga.

SoloStar Syrrrr Syringe pen imapereka moyenera insulini ndipo ndi yoyenera kugwiritsa ntchito. Zimafunikanso kusamala mosamala. Pewani zochitika zomwe zowonongeka mu SoloStar® Syringe pen zingachitike.Ngati mukukayikira kuti cholembera cha SoloStar® syringe chitha kuwonongeka, gwiritsani ntchito cholembera chatsopano.

Gawo 1. Kuwongolera kwa insulin

Muyenera kuyang'anitsitsa cholembera pa SoloStar® Syringe pen kuti muwonetsetse kuti ili ndi insulin yolondola. Pambuyo pochotsa kapu ya cholembera, ma insulini omwe ali momwemo amawongolera: yankho la insulini liyenera kukhala lowonekera, lopanda utoto, losakhala ndi tinthu tolimba tomwe timakhala ngati madzi.

Gawo 2. Kulumikiza singano

Ma singano okhawo omwe amagwirizana ndi SoloStar® Syringe pen ayenera kugwiritsidwa ntchito.

Pa jakisoni wotsatira, gwiritsani ntchito singano yatsopano yosabala. Pambuyo pochotsa chipewa, singano iyenera kuyikiridwa mosamala pa cholembera.

Gawo 3. Kuyesa Kwachitetezo

Pamaso pa jekeseni iliyonse, ndikofunikira kuyeserera chitetezo ndikuonetsetsa kuti cholembera ndi singano zimagwira bwino komanso thovu lakum air limachotsedwa.

Pimani mlingo wofanana ndi 2 PIERES.

Zingano zakunja ndi zamkati zimayenera kuchotsedwa.

Ikani cholembera mu singano ndi singano, pang'onopang'ono pa kathumba ka insulini ndi chala chanu kuti thovu lonse la mlengalenga lisunthidwe kuloza singano.

Kanikizani (kwathunthu) batani la jakisoni.

Ngati insulini ikuwonekera pachimake pa singano, izi zikutanthauza kuti cholembera ndi singano zikugwira ntchito moyenera.

Ngati insulini siziwoneka pamphepete mwa singano, ndiye kuti gawo 3 limabwerezedwa mpaka insulini ikawonekere kumapeto kwa singano.

Gawo 4. Kusankha Mafuta

Mlingo ukhoza kukhazikitsidwa ndikulondola kwa 1 UNIT, kuyambira pa mlingo wocheperako (1 UNIT) kufikira wambiri (80 UNIT). Ngati kuli kofunikira kukhazikitsa mlingo wowonjezera wa PISCES 80, jakisoni wa 2 kapena kupitilira uyenera kuperekedwa.

Zenera la dosing likuyenera kuwonetsa "0" mukamaliza kuyesa kwa chitetezo. Pambuyo pake, mlingo wofunikira ukhoza kukhazikitsidwa.

Gawo 5. Mlingo

Wodwala ayenera kudziwitsidwa za njira ya jakisoni ndi katswiri wazachipatala.

Singano iyenera kuyikiridwa pansi pa khungu.

Batani la jakisoni liyenera kukanikizidwa kwathunthu. Imasungidwa m'malo ano kwa 10 s mpaka singano itachotsedwa. Izi zimathandizira kuyambitsa mtundu wa insulin kwathunthu.

Gawo 6. Kuchotsa ndi kutaya singano

Nthawi zonse, jekeseni aliyense atavulala, singano imayenera kuchotsedwa ndikuchotsedwa. Izi zimathandizira kupewa kuipitsidwa ndi / kapena kutenga kachilomboka, kulowa mu chidebe cha insulin ndi kutulutsa insulin.

Pochotsa ndi kutaya singano, muyenera kusamala mosamala. Malangizo otetezedwa oyenera kuchotsa ndi kuponyera singano (mwachitsanzo, njira yovalira chipewa ndi dzanja limodzi) amayenera kuonedwa kuti athetse ngozi za ngozi zogwiritsidwa ntchito ndi singano komanso kupewa matenda.

Mukachotsa singano, tsekani cholembera cha SoloStar ® ndi chipewa.

Magulu apadera a odwala

Matenda aimpso. Kufunika kwa insulini pakukanika kwa impso kumatha kuchepa.

Kuwonongeka kwa chiwindi. Odwala omwe ali ndi vuto la chiwindi, vuto la insulin lingathe kuchepa chifukwa cha kuchepetsedwa kwa gluconeogeneis komanso kuchepa kwa insulin metabolism.

Odwala okalamba. Zambiri zomwe zimapezeka mu pharmacokinetics mu odwala okalamba omwe ali ndi matenda osokoneza bongo ndi osakwanira. Kugwedezeka kwa impso muukalamba kungachititse kuchepa kwa insulin.

Ana ndi achinyamata. Apidra® ikhoza kugwiritsidwa ntchito mwa ana opitilira zaka 6 ndi achinyamata. Zambiri zamankhwala pazokhudza kugwiritsa ntchito mankhwalawa kwa ana osakwana zaka 6 ndizochepa.

Kodi zingakwanitse bwanji?

Humalog mwachangu kuposa mankhwala ena amatha kupangitsa kuti shuga azikhala kwambiri. Chifukwa chake, ndibwino kukhala nanu pokhapokha pachitika ngozi. Komabe, ochepa omwe ali ndi matenda ashuga omwe akufuna kugwiritsa ntchito onse aifupi ndi a insulin.Ngati muthana ndi kagayidwe kakang'ono ka shuga wanu wamafuta ochepa, mungathe kudutsa ndi mankhwala osakhalitsa.

Kodi jakisoni aliyense amatalika bwanji?

Jekeseni aliyense wa mankhwala a Humalog amatha pafupifupi maola anayi. Anthu odwala matenda ashuga omwe amatsata amafunika Mlingo wambiri wa insulin. Nthawi zambiri imayenera kuchepetsedwa kuti ipange jekeseni woyenera wa mankhwala osakwana 0,5-1. Humalog imatha kuchepetsedwa osati kwa ana omwe ali ndi matenda a shuga 1, komanso odwala akuluakulu. Chifukwa ndi mankhwala amphamvu kwambiri. Mukamagwiritsa ntchito mankhwala ochepa, insulin imasiya kugwira ntchito mwachangu kuposa momwe amafunidwira. Mwina jakisoni amatha kumapeto kwa maola awiri ndi awiri ndi awiri.

Pakapita jakisoni iliyonse ya kukonzekera kwa ultrashort, muyezetse magazi osachepera maola atatu pambuyo pake. Chifukwa kufikira nthawi ino, mlingo wa insulin wolandirira ulibe nthawi kuti uwonetse mphamvu yake yonse. Monga lamulo, odwala matenda ashuga amapereka jakisoni wa insulin yofulumira, idyani, kenako kuyeza shuga kale chakudya chotsatira. Pokhapokha ngati wodwala akumva. Zikatero, muyenera kudziwa nthawi yomweyo kuchuluka kwa shuga m'magazi ndipo ngati kuli koyenera, chitanipo kanthu.

Ndi insulin iti yomwe ili bwino: Humalog kapena NovoRapid?

Pangakhale palibe chidziwitso cholondola choyankha funso ili, lomwe nthawi zambiri limafunsidwa ndi odwala. Chifukwa mitundu yambiri ya insulini imakhudza aliyense wodwala matenda ashuga payekhapayekha. Monga Humalog, ali ndi mafani ambiri. Monga lamulo, odwala amapaka jakisoni mankhwala omwe amapatsidwa kwaulere.

Ziwengo zimakakamiza ena kuti asinthe mtundu wina wa insulin kupita ku wina. Tikubwerezanso kuti, ngati tikuwonetsetsa kuti insulin isanachitike, tisanadye, ndi bwino kugwiritsa ntchito mankhwala achidule, mwachitsanzo, m'malo mwa ultrashort Humalog, NovoRapid kapena Apidra. Ngati mukufuna kusankha mitundu yoyenera ya insulin yowonjezera komanso yachangu, ndiye kuti simungathe kuchita popanda kuyesa komanso zolakwika.

Mndandanda wa insulin Humalog (lispro) - awa ndi mankhwala osokoneza bongo komanso. Kapangidwe ka mamolekyulu awo ndiosiyana, koma pochita nawo zilibe kanthu. akuti Humalog amachita mwachangu komanso mwamphamvu kuposa anzawo. Komabe, si odwala onse omwe amatsimikizira izi. Pamabwalo a odwala matenda ashuga olankhula Chirasha, mutha kupeza mawu otsutsa.

Odwala omwe ali ndi matenda amtundu wa 1 ndi mtundu wa 2 omwe amawonera angayesere kusintha insulin lispro ndi mankhwala osakhalitsa. Mwachitsanzo, pa. Pamwambapo zalembedwa mwatsatanetsatane chifukwa chake izi ndizoyenera kuchita. Komanso, insulin yochepa ndiyotsika mtengo. Chifukwa adalowa m'msika zaka zambiri m'mbuyomu.

Wopanga

1. Sanofi-Aventis Deutschland GmbH, Germany.

2. CJSC Sanofi-Aventis Vostok, Russia. 302516, Russia, Dera la Oryol, Chigawo cha Oryol, s / n Bolshekulikovskoye, ul. Livenskaya, 1.

Zodandaula za ogula ziyenera kutumizidwa ku adilesi yoyimilira kampaniyo ku Russia: 125009, Moscow, ul. Tverskaya, 22.

Tele. ((495) 721-14-00, fakisi: (495) 721-14-11.

Pankhani yopanga mankhwalawa ku Sanofi-Aventis Vostok CJSC, Russia, madandaulo a ogula ayenera kutumizidwa ku adilesi iyi: 302516, Russia, Oryol Region, Oryol District, s / n Bolshekulikovskoye, Livenskaya, 1.

Tele./fax: +7 (486) 244-00-55.

Apidra ndi mankhwala ochita chiyani?

Anthu ambiri amakhulupirira kuti Apidra ndi insulin yochepa. M'malo mwake, ndi mankhwala a ultrashort. Siyenera kusokonezedwa ndi insulin ya insrapid, yomwe ndiyifupi. Pambuyo pa utsogoleri, Apidra wowerengeka-pang'ono amayamba kuchita mwachangu kuposa kukonzekera kwakanthawi. Komanso, zochita zake zimatha posachedwa.

Makamaka, mitundu yochepa ya insulini imayamba kuchita mphindi 20-30 pambuyo pa jekeseni, ndi ultrashort Apidra, Humalog ndi NovoRapid - itatha mphindi 10-15. Amachepetsa nthawi yomwe wodwala matenda ashuga ayenera kudikira asanadye. Zambiri zikuwonetsa. Wodwala aliyense amakhala ndi nthawi yake yoyambira payekha komanso mphamvu ya zochita za jakisoni wa insulin. Kuphatikiza pa mankhwalawa omwe amagwiritsidwa ntchito, amadalira tsamba la jakisoni, kuchuluka kwa mafuta m'thupi ndi zinthu zina.

Chonde dziwani kuti odwala omwe ali ndi shuga omwe amatsata zakudya zama carb otsika, jakisoni wa insulin yochepa musanadye bwino kuposa mankhwala a ultrashort. Chowonadi ndichakuti zakudya zama carb zotsika mtengo zomwe zimakhala zopindulitsa kwa odwala matenda ashuga zimatengedwa pang'onopang'ono ndi thupi. Apidra amatha kuyamba kutsika shuga kale kwambiri kuposa puloteni yomwe idadyedwa ndikupukusidwa ndipo gawo lina limasandulika kukhala glucose. Chifukwa cha kusiyana pakati pa kuchuluka kwa zochita za insulin ndi chakudya, shuga m'magazi amatha kuchepa kwambiri, kenako nkudzukanso. Ganizirani kusintha kuchokera ku insulin Apidra kukhala mankhwala osakhalitsa, monga Actrapid NM.

Kodi nthawi ya jakisoni wa mankhwalawa ndi yotani?

Jekeseni aliyense wa insulin Apidra ndiwothandiza kwa maola pafupifupi anayi. Chiphuphu chotsalira chimakhala mpaka maola 5-6, koma sizofunikira. Kuchuluka kwa zochitika pambuyo pamaora 1-3. Muziwonetsanso shuga pasanadutse maola 4 kuchokera insulin. Kupanda kutero, mlingo wolandidwa wa mahomoni ulibe nthawi yokwanira kuchitapo kanthu. Yesetsani kuti musalole Mlingo wa insulin iwiri yolimba kuti uzizungulira nthawi yomweyo. Kuti izi zitheke, jakisoni wa Apidra uyenera kuchitidwa mosiyanasiyana kwa maola osachepera anayi.

Werengani za malonda a odwala matenda ashuga: Zipatso za uchi uchi Porridge Batala ndi mafuta a masamba