Isofan Insulin > Insulin

Type 2 shuga mellitus, gawo la kukana mankhwalawa a hypoglycemic, kutsutsana kwapakamwa kwa mankhwala a hypoglycemic (kuphatikiza mankhwala), matenda oyanjana, chithandizo cha opaleshoni (mono- kapena chithandizo chamankhwala), matenda a shuga nthawi yayitali.

Momwe mungagwiritsire ntchito: Mlingo ndi njira ya chithandizo

P / C, katatu patsiku, mphindi 30-45 musanadye kadzutsa (sinthani malo a jekeseni nthawi iliyonse). Mwapadera, adokotala amatha kukupatsani jakisoni wa / m mankhwala. Mu / pakubweretsa insulin ya sing'anga nthawi yoletsedwa! Mlingo amasankhidwa payekha ndipo zimatengera zomwe zili ndi shuga m'magazi ndi mkodzo, mawonekedwe a matendawa. Nthawi zambiri, Mlingo ndi 8-24 IU 1 nthawi patsiku. Akuluakulu ndi ana omwe ali ndi chidwi chambiri ndi insulin, mlingo wochepera 8 IU / tsiku ukhoza kukhala wokwanira, mwa odwala omwe ali ndi kuchepa kwa chidwi - oposa 24 IU / tsiku. Pa mlingo wa tsiku lililonse wopitilira 0,6 IU / kg, - wofanana ndi jakisoni 2 m'malo osiyanasiyana. Odwala omwe amalandila 100 IU kapena kuposerapo patsiku, akachotsa insulin, ndikofunika kuchipatala. Kusamutsa kuchokera ku mankhwala kupita ku wina kuyenera kuchitika mothandizidwa ndi shuga wamagazi.

Zotsatira za pharmacological

Insulin yochita pakati. Kuchepetsa kuchuluka kwa shuga m'magazi, kuonjezera mayamwidwe ndi minofu, kumapangitsanso lipogenis ndi glycogenogeneis, kaphatikizidwe ka mapuloteni, kumachepetsa kuchuluka kwa shuga ndi chiwindi.

Imalumikizana ndi cholandirira china kumtundu wakunja wamaselo ndikupanga insulini yolandirira. Mwa kuyambitsa kaphatikizidwe ka cAMP (m'maselo amafuta ndi maselo a chiwindi) kapena kulowa mwachindunji mu cell (minofu), insulini yolandirira insulin imapangitsa njira zina, kuphatikizira kaphatikizidwe angapo ofunikira a michere (hexokinase, pyruvate kinase, glycogen synthetase, etc.). Kutsika kwa shuga wamagazi kumachitika chifukwa cha kuchuluka kwa kayendedwe kake ka chidwi, kuchuluka kwa zotupa, kukondoweza kwa lipogenesis, glycogenogeneis, kaphatikizidwe ka mapuloteni, kuchepa kwa kuchuluka kwa kupanga kwa shuga ndi chiwindi (kuchepa kwa kuphwanya glycogen), ndi zina zambiri.

Pambuyo pa jekeseni wa sc, matendawa amapezeka maola 1-1.5. Kuchuluka kwake kumachitika pakatikati pa maola 4-12, kutalika kwa nthawi ndi maola 11 mpaka 24, kutengera kapangidwe ka insulini ndi mlingo, kumawonetsa kupatuka kwakapakati komanso mkati mwa munthu.

Zotsatira zoyipa

Thupi lawo siligwirizana (urticaria, angioedema - malungo, kufupika, kuchepa kwa magazi),

hypoglycemia (pallor of the khungu, thukuta kwambiri, thukuta, pakamwa, kunjenjemera, njala, kusokonezeka, nkhawa, paresthesias mkamwa, kupweteka mutu, kugona, kugona, mantha, kupsinjika, kusakwiya, chikhalidwe chosazolowereka, kusowa kwa kayendedwe, vuto lakulankhula ndi kuyankhula komanso masomphenya), hypoglycemic coma,

hyperglycemia ndi matenda ashuga acidosis (pamiyeso yotsika, kudumpha jakisoni, kadyedwe koyipa, kutentha thupi ndi matenda): kuwodzera, ludzu, kufooka kwa chakudya, kutulutsa nkhope),

kuda nkhawa (mpaka kukula kwa precomatose ndi chikomokere),

kuchepa kwakanthawi kowoneka (nthawi zambiri kumayambiriro kwa zamankhwala),

immunological cross-reaction ndi insulin ya anthu, kuwonjezeka kwa gawo la anti-insulin antibodies, kenako kuwonjezeka kwa glycemia,

Hyperemia, kuyabwa ndi lipodystrophy (atrophy kapena hypertrophy of subcutaneous fat) pamalo a jekeseni.

Kumayambiriro kwa mankhwalawa - edema ndi mkodzo womwe ungayikidwenso (ndikanthawi kochepa ndipo amazimiririka ndi chithandizo chopitilira) Zizindikiro: thukuta, thukuta, kugwedezeka, kugona, nkhawa, kupsinjika mkamwa, pallor, mutu, kugona, kusowa tulo, mantha, kupsinjika, kusakhazikika, kusazolowereka, kusayenda, kuyankhula komanso kuwona, hypoglycemic chikomokere, kukomoka.

Chithandizo: ngati wodwalayo akudziwa, adayikidwa ndi dextrose pakamwa, s / c, i / m kapena iv pobayira glucagon kapena iv hypertonic dextrose solution. Ndi chitupa cha hypoglycemic coma, 20-40 ml (mpaka 100 ml) wa 40% dextrose solution amawayamwa kudzera mu mtsempha kulowa kufikira wodwalayo atatuluka.

Malangizo apadera

Musanatenge insulini kuchokera ku vial, ndikofunikira kuti muwone mawonekedwe a yankho. Matupi achilendo atawonekera, kusefukira kapena kutentha kwa zinthu pagalasi la botolo, njira yothetsera mankhwalawa singagwiritsidwe ntchito.

Kutentha kwa insulin yoyenera kuyenera kukhala kutentha kwambiri.

Mlingo wa insulin uyenera kusinthidwa matenda opatsirana, matenda a chithokomiro, matenda a Addison, hypopituitarism, kulephera kwaimpso ndi matenda ashuga okonda anthu opitirira zaka 65.

Zomwe zimayambitsa hypoglycemia zimatha kukhala: kuchuluka kwa insulini, kusintha mankhwala osokoneza bongo, kudumpha chakudya, kusanza, kutsegula m'mimba, kupsinjika kwa thupi, matenda omwe amachepetsa kufunika kwa insulin (matenda apamwamba a impso ndi chiwindi, komanso hypofunction ya adrenal cortex, pituitary kapena chithokomiro chithokomiro), kusintha malo jakisoni (mwachitsanzo, khungu pamimba, phewa, ntchafu), komanso mogwirizana ndi mankhwala ena. Ndikotheka kuchepetsa kuchuluka kwa shuga m'magazi posamutsa wodwala kuchokera ku insulin ya nyama kupita ku insulin ya anthu. Kusamutsa wodwala kupita ku insulin yaumunthu kuyenera kukhala koyenera nthawi zonse kumayang'aniridwa ndi adokotala.

Chizolowezi chokhala ndi hypoglycemia chimatha kuvulaza kuthekera kwa odwala kutenga nawo mbali mokwanira mumsewu, komanso kukonza makina ndi zida zamagetsi.

Odwala omwe ali ndi matenda ashuga amatha kuyimitsa pang'ono hypoglycemia yomwe amamva pakudya shuga kapena zakudya zamagulu owonjezera (tikulimbikitsidwa kuti nthawi zonse muzikhala ndi shuga osachepera 20 g). About hypoglycemia yomwe yasamutsidwa, ndikofunikira kudziwitsa dokotala kuti apangire pakufunika kwa chithandizo chamankhwala. Pa nthawi yoyembekezera, ndikofunikira kuganizira kuchepa (I trimester) kapena kuwonjezeka (II-III trimesters) pazofunikira za insulin. Nthawi yobadwa pambuyo pokhapokha ndipo mwayamba kubadwa, zofunika za insulin zimatha kugwa kwambiri. Pa mkaka wa m`mawere, kuwunikira tsiku ndi tsiku kumafunikira kwa miyezi ingapo (mpaka kufunika kwa insulin kukhazikika).

Kuchita

Mankhwala osagwirizana ndi mayankho a mankhwala ena.

Mphamvu ya hypoglycemic imapangidwira ndi sulfonamides (kuphatikizapo mankhwala a hypoglycemic, sulfonamides), ma inhibitors a MAO (kuphatikizapo furazolidone, procarbazine, selegiline), carbonic anhydrase inhibitors, ACE inhibitors, NSAIDs (kuphatikizapo salicylates), anabolic (kuphatikiza stanozolol, oxandrolone, methandrostenolone), androgens, bromocriptine, tetracyclines, clofibrate, ketoconazole, mebendazole, theophylline, cyclophosphamide, phenfluramine, Li + kukonzekera, pyridoxine, quinidine, quinine, etloroquin, etloro.

Zotsatira Hypoglycemic wa kulemala glucagon, kukula timadzi, corticosteroids m'kamwa kulera, estrogens, thiazide ndi kuzungulira okodzetsa, mahomoni BCCI, chithokomiro, heparin, sulfinpyrazone, sympathomimetics, danazol, tricyclics, clonidine, calcium muzikangana, diazoxide, morphine, chamba, fodya, phenytoin, epinephrine, H1-histamine receptor blockers.

Beta-blockers, reserpine, octreotide, pentamidine imatha kuwongolera ndi kufooketsa mphamvu ya hypoglycemic ya insulin.

Zizindikiro zogwiritsidwa ntchito ndi mayina ogulitsa a mankhwalawa

Kugwiritsa ntchito mankhwalawo kumasonyezedwa ngati mtundu wa shuga womwe umadalira insulin. Komanso, chithandizo chamankhwala chiyenera kukhala moyo wonse.

Insulin monga Isofan ndi mankhwala opangidwa ndi chibadwa cha anthu omwe amalembedwa mu milandu yotere:

mtundu 2 shuga (wodalira insulin),
opaleshoni njira
kukana hypoglycemic wothandizila kumwa pakamwa monga mbali ya zovuta mankhwala,
matenda a shuga (osagwiritsa ntchito mankhwalawa),
pafupipafupi matenda.

Makampani opanga mankhwala amapanga insulin yaumunthu yopangidwa ndi mayina osiyanasiyana. Odziwika kwambiri ndi Vozulim-N, Biosulin-N, Protafan-NM, Insuran-NPH, Gensulin-N.

Mitundu ina ya isofan insulin imagwiritsidwanso ntchito ndi awa:

Wopanda pake
Humulin (NPH),
Pensulin,
Isofan insulin NM (Protafan),
Actrafan
Insulidd N,
Biogulin N,
Chitetezo cha Protafan-NM.

Ndikofunikira kudziwa kuti kugwiritsa ntchito tanthauzo lililonse la Insulin Isofan kuyenera kuvomerezana ndi adokotala.

Mlingo ndi makonzedwe

Malangizo ogwiritsira ntchito insulin Isofan akunena kuti nthawi zambiri amathandizidwa mosavomerezeka mpaka 2 pa tsiku musanadye kadzutsa. Pankhaniyi, muyenera kusintha jakisoni tsiku lililonse ndikusunga syringe yomwe imagwiritsidwa ntchito kutentha kwa chipinda, ndi yatsopano mufiriji.

Nthawi zina mankhwala kutumikiridwa intramuscularly. Ndipo njira yolowerera yogwiritsira ntchito insulin yomwe imagwiritsa ntchito siigwiritsidwa ntchito.

Mlingo amawerengedwa payekhapayekha kwa wodwala aliyense, potengera kuchuluka kwa kuchuluka kwa shuga m'magazi achilengedwe komanso kutsimikizika kwa matendawa. Monga lamulo, avareji ya tsiku ndi tsiku imachokera ku 8-24 IU.

Ngati odwala ali ndi insulin, ndiye kuti tsiku lililonse mankhwalawo ndi 8 IU. Ndi chiwopsezo chovuta cha mahomoni, mlingo umawonjezeka - kuyambira 24 IU patsiku.

Ngati kuchuluka kwa tsiku ndi tsiku kwamankhwala kumaposa 0,6 IU pa 1 makilogalamu, ndiye kuti jakisoni awiri amapangidwa mbali zosiyanasiyana za thupi. Odwala omwe ali ndi tsiku lililonse la 100 IU kapena kuposerapo ayenera kugonekedwa m'chipatala ngati insulin italowe m'malo.

Komanso, posamutsa kuchokera ku mtundu wina wamtundu kupita ku wina, ndikofunikira kuwunika zomwe zili ndi shuga.

Zochita Zosiyanasiyana

Kugwiritsa ntchito insulin yaumunthu kumatha kuyambitsa matupi awo. Nthawi zambiri, ndi angioedema (hypotension, kupuma movutikira, malungo) ndi urticaria.

Komanso, kupitilira muyeso kungayambitse hypoglycemia, yowonetsedwa ndi zizindikiro zotsatirazi:

kusowa tulo
chikopa,
kukhumudwa
hyperhidrosis
mantha
dziko lokondwa
palpitations
mutu
chisokonezo,
Vuto lama vestibular
njala
kugwedezeka ndi zinthu.

Zotsatira zoyipa zimaphatikizira diabetesic acidosis ndi hyperglycemia, zomwe zimawonetsedwa ndi kutulutsa nkhope, kugona, kusowa kudya komanso ludzu. Nthawi zambiri, mikhalidwe yotere imachitika motsutsana ndi maziko a matenda opatsirana komanso kutentha thupi, jekeseni ikaphonya, mulingo wake sukulondola, ndipo ngati zakudya sizitsatiridwa.

Nthawi zina kuphwanya kwa chikumbumtima kumachitika. Pamavuto, pamakhala mkhalidwe wovuta komanso wamakhalidwe.

Kumayambiriro kwa mankhwalawa, kusokonezeka kwa nthawi yochepa kumatha kuchitika. Kuwonjezeka kwa gawo la anti-insulin matupi kumadziwikanso ndi kupita patsogolo kwa glycemia komanso zochita zamagetsi zamtundu wa mtanda ndi insulin ya anthu.

Nthawi zambiri tsamba la jakisoni limatupa ndikuluma. Poterepa, mafuta onunkhira a minyewa kapena ma atrophies. Ndipo pa gawo loyambirira la zamankhwala, zolakwika zosakhalitsa ndi edema zimatha.

Ngati mankhwala osokoneza bongo ochulukirapo, shuga m'magazi amatsika kwambiri. Izi zimayambitsa hypoglycemia, ndipo nthawi zina wodwala amagwa.

Ngati mulingo wachepera, muyenera kumwa zakudya zamatumbo ambiri (chokoleti, mikate yoyera, mpukutu, maswiti) kapena kumwa chakumwa chokoma kwambiri. Pakukhumudwa, yankho la dextrose (40%) kapena glucagon (s / c, v / m) limaperekedwa kwa wodwala mu / mu.

Wodwala akayambanso kudziwa bwino, ndikofunikira kumudyetsa chakudya chamafuta ambiri.

Izi zimapangitsa kuti matenda obwera chifukwa cha hypoglycemic ayambirenso kuchepa.

Zimagwira bwanji?

Isofan insulin umangidwe wa chibadwa cha anthu umakhudza thupi, kupereka mphamvu ya hypoglycemic. Mankhwalawa amakumana ndi ma cytoplasmic receptors a cell membrane. Izi zimapanga zovuta za insulin receptor. Ntchito yake ndikupanga kagayidwe kamphamvu kamene kamachitika mkati mwa maselo iwowo, ndikuthandizanso pakupanga kwakukulu kwa michere yonse yomwe ilipo.

Kuchepetsa kuchuluka kwa shuga m'magazi kumachitika ndikuwonjezera mayendedwe ake mkati mwa cell, komanso mwa kuchepetsa kuchuluka kwa shuga, pothandizira pakuyamwa. Ubwino wina wa insulin ya anthu ndi kaphatikizidwe wa mapuloteni, kutsegula kwa lithogenesis, glycogenogeneis.

Nthawi yayitali yomwe mankhwalawa amagwira mwachindunji molingana ndi kuchuluka kwa momwe mankhwalawa amathandizira kulowa m'magazi, ndipo mayamwidwe ake amatengera njira yoyendetsera ndi mankhwalawa. Chifukwa chake, zotsatira za mankhwalawa ndizosiyana mwa odwala osiyanasiyana.

Pachikhalidwe, pambuyo pa jekeseni, mphamvu ya mankhwalawa imayamba pambuyo pa maola 1.5. Chiwopsezo cha kugwira ntchito zimachitika pang'onopang'ono maola 4 mutatha kuperekera mankhwala. Kutalika kwa kuchitapo kanthu ndi maola 24.

Kuchuluka kwa Isofan kumadalira izi:

Tsamba la jekeseni (matako, pamimba, ntchafu),
Yogwira pophika
Mlingo.

Mankhwalawa amachotseredwa ndi impso.

Momwe mungagwiritsire ntchito: Zizindikiro zakugwiritsa ntchito

Malinga ndi malangizo ogwiritsidwira ntchito a Isofan, amayenera kuperekedwa kawiri patsiku: m'mawa ndi madzulo asanadye (30-30 mphindi asanadye). Tsamba la jakisoni liyenera kusinthidwa tsiku lililonse, syringe yomwe idagwiritsidwa ntchito iyenera kusungidwa pamwambo wabwinobwino, kutentha kwatsopano, ndipo yatsopano iyenera kukhala mumapaketi, mufiriji. Nthawi zambiri, mankhwalawa amalowetsedwa m'matumbo, koma osagwirizana konse, chifukwa ndi insulin.

Mlingo wa mankhwalawa amawerengedwa aliyense payekha kwa aliyense amene ali ndi matenda a shuga, pokambirana ndi adokotala. Kutengera kuchuluka kwa shuga mu plasma ndi kutsimikiza kwa shuga. Mlingo wambiri watsiku ndi tsiku, mosiyanasiyana umasiyana pakati pa 8-24 IU.

Ngati hypersensitivity kwa insulin, ndikofunikira kutenga zosaposa 8 IU patsiku, ngati mahomoni samadziwika bwino, mlingo ungathe kuwonjezeka mpaka 24 kapena kuposa IU masana. Ngati mlingo wa tsiku ndi tsiku wa mankhwalawa uzidutsa 0 6 IU pa kilogalamu ya thupi la wodwalayo, ndiye kuti jakisoni 2 amapangidwa nthawi imodzi m'malo osiyanasiyana.

Urticaria,

Mankhwala osokoneza bongo a mankhwala ambiri amakhala ndi hypoglycemia ndi chikomokere. Kuchulukitsa kwa mankhwalawa sikungasokonezeke ngati mumadya zakudya zopatsa thanzi (chokoleti, maswiti, makeke, tiyi wokoma).

Pofuna kutaya chikumbumtima, yankho la Dextrose kapena Glucagon liyenera kuperekedwa kwa wodwala. Chikumbumtima chikadzabweranso, wodwala amayenera kupatsidwa chakudya chambiri chamagulu omoto. Izi zitha kupewa kuti glycemic coma ndi hypoglycemic zibwererenso.

Insulin-isophan: malangizo ogwiritsira ntchito kuyimitsidwa

Dzina lachi Latin: insulinum isophanum
Code ya ATX: A10a
Chithandizo: insulin-human genetic engineering isophane

Wopanga: Novo Nordisk, Denmark

Zoyenera kusiya kuchokera ku mankhwala: Ndi mankhwala
Malo osungira: t mkati mwa 2-8 madigiri
Tsiku lotha ntchito: Zaka 2

Insulin isofan isofan yogwiritsa ntchito chibadwa cha anthu imagwiritsidwa ntchito pochiza matenda omwe amapezeka chifukwa cha kupangika kwa mphamvu ya thupi la munthu ndi insulin. Palibe mankhwala omwe ali ndi dzina ili pamalonda, popeza uwu ndi mtundu wa chinthu chogwira ntchito, koma pali ma fanizo. Chitsanzo chowoneka bwino cha chinthu chomwe chimagulitsidwa ndi rinsulin.

Isofan insulin: ndingagwiritse ntchito ndi mankhwala ena

Kuchulukitsa kwa hypoglycemic (kusintha shuga kwa magazi) matenda a Isofan ndi:

Sulfonamides,
Chloroquinine
ACE inhibitors / MAO / carbonic anhydrase,
Ethanoli
Mebendazole,
Njira zomwe zili m'gulululi ndi anabolic steroids,
Fenfluramine
Mankhwala a Tetracycline
Clofibrate
Malangizo a gulu la theofylline.

Mphamvu ya hypoglycemic (kubweretsa kuchuluka kwa shuga m'magazi kuti ikhale yofananira) imachepetsedwa chifukwa cha matenda a Isofan omwe ali ndi mankhwalawa:

Somatropin
Epinephrine
Njira zolera
Epinephrine
Phenytoin
Otsutsa a calcium.

Kuchuluka kwa shuga m'magazi kumachepa chifukwa cha mtundu wa insulin Isofan wokhala ndi thiazide ndi loop diuretics, wokhala ndi BMCC, komanso mahomoni a chithokomiro, sympathomimetics, Klondin, Danazole, sulfinpyrazone. Morphine, chamba, mowa ndi chikonga zimachetsanso shuga m'magazi. Odwala omwe ali ndi matenda ashuga sayenera kumwa kapena kusuta.

Kuphatikiza pakuphatikiza kwamankhwala osayenera ndi Isofan, zinthu monga zomwe zimayambitsa hypoglycemia komanso:

Mukasinthira ku mankhwala ena omwe amakhala ndi shuga wamba,
Kusanza kwa matenda ashuga
Matenda a shuga
Kuchuluka kwathupi katundu
Matenda omwe amachepetsa kufunika kwa insulin (pituitary, hypothyroidism, kulephera kwa chiwindi, kulephera kwaimpso),
Wodwala sanadye pa nthawi.
Kusintha kwa tsamba la jakisoni.

Mlingo wosalondola kapena nthawi yayitali pakati pa jakisoni ingayambitse matenda a hyperglycemia (makamaka munthawi ya matenda a shuga 1). Ngati mankhwalawa sasinthika pakapita nthawi, wodwalayo amatha kugwa ketoacidotic.

Wodwala yemwe amagwiritsa ntchito mankhwalawa ndi okalamba kuposa zaka makumi asanu ndi limodzi, ndipo makamaka yemwe ali ndi vuto la chithokomiro, impso, kapena chiwindi, ndikofunikira kufunsa dokotala wothandizirana ndi kuchuluka kwa insulin Isofan. Njira zomwezi ziyenera kumwedwa ngati wodwala akudwala hypopituitarism kapena matenda a Addison.

Momwe mungasinthire: malangizo apadera

Musanamwe mankhwalawo mu syringe, onani ngati yankho lake ndi mitambo. Ziyenera kukhala zowonekera. Ngati ma ntchofu, matupi akunja aoneka, yankho lafika pamtambo, mpweya watuluka, mankhwalawo sangathe kugwiritsidwa ntchito.

Kutentha kwa mankhwala operekedwa kuyenera kukhala kutentha kwa chipinda. Ngati pakadali pano muli ndi chimfine kapena zambiri ndi matenda ena opatsirana, muyenera kufunsa dokotala za mankhwalawa. Mukalowetsa mankhwalawa, izi zikuyenera kuchitika moyang'aniridwa ndi dokotala, ndikwanzeru kupita kuchipatala.

Mimba, mkaka wa m`mawere ndi insulin Isofan

Amayi oyembekezera omwe ali ndi matenda ashuga amatha kutenga Isofan insulin, sangafike kwa fetus kudzera mu placenta. Mutha kugwiritsa ntchito ndi kuyamwitsa amayi, okakamizidwa kuti mukhale ndi matenda. Ndikofunikira kudziwa kuti panthawi yomwe muli ndi pakati pa trimester yoyamba, kufunika kwa insulin kumachepa, ndipo wachiwiri ndi wachitatu trimester imawonjezeka.

Zizindikiro zogwiritsidwa ntchito

Chizindikiro chachikulu ndicho chithandizo cha matenda amishuga amtundu 1, koma nthawi zina amatha kufotokozedwa pamaso pa matenda a insulin. Chuma chilichonse cha isophane ndi choyenera kuchiza munthu yemwe samatenganso zinthu za hypoglycemic chifukwa chokana kwathunthu kapena pang'ono. Pafupipafupi, mankhwala amagwiritsidwa ntchito mwa amayi apakati omwe ali ndi mtundu wachiwiri wa matenda ashuga.

Kupanga ndi mafomu omasulira

1 ml yankho lili ndi magawo 100 a yogwira zinthu. Zothandiza - protamine sulfate, madzi osabala a jakisoni, crystalline phenol, sodium dihydrate phosphate, glycerol, metacresol.

Kuyimitsidwa kwa jakisoni, wowonekera. Botolo imodzi ili ndi 3 ml ya chinthu. Phukusi limodzi mumakhala ma cartridge 5 kapena amagulitsidwa m'botolo limodzi 10 ml ya mankhwalawo.

Kuchiritsa katundu

Isofan insulin ndi nthawi yayitali yogwira chinthu cha hypoglycemic, yomwe idapangidwa pogwiritsa ntchito ukadaulo wa DNA.

Pambuyo pa subcutaneous makonzedwe, mahomoni amkati amamangira ku insulin receptor zovuta, zomwe zimapangitsa kuphatikizika kwa mitundu yambiri ya enzyme - hexokinase, pyruvate kinase ndi ena.

Chifukwa cha zinthu zomwe zimayambitsidwa kuchokera kunja, kuchuluka kwa shuga m'thupi kumawonjezeka, chifukwa kumatheka kwambiri ndi minofu, ndipo kuchuluka kwa shuga kwa chiwindi kumachepetsedwa kwambiri. Pogwiritsa ntchito pafupipafupi, mankhwalawa amayambitsa machitidwe a lipogenesis, glycogenogeneis ndi proteininogene.

Kutalika kwa kuchitapo kanthu komanso kuchuluka kwa magwiridwe antchito mwa anthu osiyanasiyana kumatengera zinthu zambiri, makamaka makamaka pa kuthamanga kwa zochita za metabolic. Zikutanthauza chiyani - njirayi ndi payekha.

Pafupifupi, popeza iyi ndi timadzi tambiri tomwe timathamanga, zotsatira zake zimayamba mkati mwa ola limodzi ndi theka kuyambira panthawiyi yopanga zinthu.

Kutalika kwa mavutowa ndi maola 24, kuchuluka kwa chidwi kumachitika mkati mwa maola 4-12.

Mankhwalawa amamwetsa mosiyanasiyana, wowoneka bwino kwambiri kudzera mu impso, kuwopsa kwa zotsatirazi kumadalira malo a jekeseni (m'mimba, mkono kapena ntchafu). Mankhwalawa samadutsa chopinga komanso kulowa mkaka wa m'mawere, chifukwa chake amaloledwa kwa amayi apakati komanso ongobadwa kumene.

Njira yogwiritsira ntchito

Mtengo wapakati wa mankhwala ku Russia ndi ma ruble 1075 pa paketi iliyonse.

Kubaya jakisoni, kamodzi patsiku, m'malo osiyanasiyana. Pafupipafupi jakisoni malo amodzi sayenera kupitirira nthawi 1 pamwezi, chifukwa chake malo oyendetsera mankhwalawa amasinthidwa nthawi iliyonse.

Asanagwiritse ntchito mwachindunji, ma ampoules adagulungika m'manja.

Malangizo oyendetsera jakisoni - chithandizo chosawoneka bwino, singano amaikidulira modzitchinjiriza kwa madigiri 45 mu khola loponderezedwa, pomwepo malowo ndi ophera tizilombo toyambitsa matenda. Mlingo amasankhidwa ndi dokotala payekhapayekha.

Pa nthawi yoyembekezera komanso yoyamwitsa

Mankhwala amavomerezedwa kuti azigwiritsidwa ntchito nthawi izi.

Contraindication ndi Kusamala

Izi zimaphatikizira: kusalolera ku chinthu china chake chogwira ntchito komanso shuga pang'ono panthawi inayake.

Kuchita mankhwala osokoneza bongo

Kuchepetsa mphamvu ya mankhwalawa: systemic glucocorticoids, kulera kwapakamwa, estradiol ndi progesterone, anabolic steroids, diuretics, antidepressants, mahomoni a chithokomiro.

Kuchulukitsa ntchito: mowa, salicylates, sulfonamides ndi beta-blockers, Mao inhibitors.

Zotsatira zoyipa ndi bongo

Hypoglycemia kapena lipodystrophy ndikotheka ngati malamulo a jekeseni ndi mankhwala omwe sanatsatire satsatiridwa. Zocheperako ndizotsatira zoyipa mwanjira ya thupi lawo siligwirizana, kufupika, kutsitsa magazi, hyperhidrosis ndi tachycardia.

Pankhani ya mankhwala osokoneza bongo, zizindikiro zapamwamba za shuga m'magazi zimawonekera: kumva kwamphamvu njala, kufooka, kusazindikira, chizungulire, thukuta, kufunitsitsa kudya maswiti, milandu yayikulu - chikomokere. Zizindikiro zofatsa zimayimitsidwa ndi kudya kwamphamvu thupi, pakati - ndi jakisoni wa dextrose kapena glucose. Nthawi zambiri pamafunika kuyitanidwa kwa madokotala kunyumba.

Rinsulin PNH

Geropharm-bio LLC, Russia

Mtengo wapakati ku Russia - ma ruble 1000 phukusi lililonse.

Rinosulin ndi analogue yathunthu ndipo imakhala ndi sing'anga wapakati. Mtundu wa mankhwalawa ndi wabwino chifukwa sufunikira kukonzekera pafupipafupi.

Ubwino:

Kugwiritsa ntchito bwino
Kupanga kwa Russia.

Chuma:

Osati otsika mtengo
Zotsatira zoyipa ndizotheka.

Humulin NPH

Eli Lilly East, Switzerland

Mtengo wapakati ku Russia - 17 ma ruble.

Humulin NPH ndi analog ya kuchuluka kwapakatikati.

Ubwino:

Mtengo wotsika
Chosavuta kugwiritsa ntchito.

Chuma:

Pali zovuta zina
Siwothandiza aliyense.

Zambiri zokhudza Biosulin N pa Pharmacy.ru

Mumasunga 104,00 rub.

kwa 1 unit - 183.00 rub.

Mumasungira 49,00 rub.

kwa 1 unit - 438.00 rub.

Mumasunga 99,00 rub.

kwa 1 unit - 256.00 rub.

Chomera cha Pharmstandard-Ufa Vitamini, JSC Russia Diabetes Means

Hypoglycemic wothandizila, yemwe amakhala pakati pa insulin.

Kutulutsa Mafomu

5 ml - mabotolo agalasi lopanda utoto (1) - mapaketi. 5 ml - mabotolo agalasi lopanda utoto (2) - ma CD a contour cell (1) - mapaketi. 5 ml - matumba a galasi lopanda utoto (3) - matumba otumphukira Kuyimitsidwa kwa makina osapindulitsa a 100 IU / ml - 3 ml ya makonzedwe opangira galasi la galasi lopanda utoto, losindikizidwa ndi kapu yophatikizika, kuti mugwiritse ntchito ndi cholembera cha Biomatic cholembera kuyimitsidwa koyenda kwa 100 Me / ml - 3 ml ya mankhwalawa katiriji kopanda galasi lopanda utoto, losindikizidwa ndi cap. Katiriji imayikidwa mu cholembera cha 2 BiomatikPen 2 kuti igwiritsidwe ntchito kamodzi. Pa ma syringes asanu a Biomatikpen 2 osagwiritsa ntchito kamodzi ndi makatiriji phukusi.

Kufotokozera za mtundu wa kipimo

Kuyimitsidwa koyera. Poimirira, kuyimitsidwa kumakhazikika, ndikupanga mpweya. Wopatsa chidwi ndi wowoneka bwino, wopanda utoto kapena wopanda mtundu. Mtengo umasinthidwa mosavuta ndikugwedezeka modekha. Kuyimitsidwa kwa s / c makonzedwe oyera, ataimirira, kuyimitsidwa kumatha, ndikupanga koyera. Wopatsa chidwi ndi wowoneka bwino, wopanda utoto kapena wopanda mtundu. Mtengo umasinthidwa mosavuta ndikugwedezeka modekha.

Pharmacokinetics

Mayamwidwe Kukwaniritsidwa kwathunthu ndi kuyambika kwa mphamvu ya insulin kumadalira malo a jakisoni (pamimba, ntchafu, matako), mlingo (kuchuluka kwa insulini), komanso kuchuluka kwa insulin pokonzekera.

Kugawidwa Kugawa minofu mosiyanasiyana. Sichidutsa chotchinga ndipo sichikumbukiridwa mkaka wa m'mawere. Metabolism Yowonongeka ndi insulinase makamaka m'chiwindi ndi impso.

Kuchotseredwa Mumkodzo - 30-80%.

Mikhalidwe yapadera

Simungathe kugwiritsa ntchito mankhwala Biosulin® N ngati, mutagwedezeka, kuyimitsidwa sikusintha kukhala koyera komanso kwamitambo. Poyerekeza ndi maziko a mankhwala a insulin, kuyang'anira kuchuluka kwa shuga m'magazi ndikofunikira.

Kuphatikiza pa kuchuluka kwa insulin, zifukwa za hypoglycemia zimatha kuphatikizira mankhwala osokoneza bongo, kudumpha chakudya, kusanza, kutsegula m'mimba, kuchuluka kwa zochitika zolimbitsa thupi, matenda omwe amachepetsa kufunika kwa insulin (chiwindi ndi matenda a impso, hypofunction ya adrenal cortex, pituitary kapena chithokomiro cha chithokomiro), kusintha kwa jekeseni wa jekeseni, komanso kucheza ndi mankhwala ena.

Malonda osokoneza bongo kapena osokonezeka mu kayendetsedwe ka insulin, makamaka kwa odwala omwe ali ndi vuto la matenda a shuga 1, angayambitse hyperglycemia. Nthawi zambiri, zizindikiro zoyambirira za hyperglycemia zimayamba pang'onopang'ono kwa maola angapo kapena masiku.

Izi zimaphatikizapo ludzu, kukodza kwambiri, kusanza, kusanza, chizungulire, khungu ndi kuwuma pakhungu, pakamwa pouma, kusowa chilimbikitso, kununkhira kwa acetone mu mpweya wotuluka. Ngati sanalandire, hyperglycemia mu mtundu 1 wa shuga angayambitse kukula kwa matenda ashuga a ketoacidosis.

Mlingo wa insulin uyenera kukonzedwa kuti matenda a chithokomiro asokonekera, matenda a Addison, hypopituitarism, chiwindi ndi / kapena ntchito ya impso, komanso matenda osokoneza bongo omwe ali ndi zaka zopitilira 65. Kuwongolera mlingo wa insulin kungafunikenso ngati wodwala akuwonjezera kuchuluka kwa zolimbitsa thupi kapena asintha zakudya zomwe amakonda.

Matenda onga (makamaka opatsirana) ndi mikhalidwe yomwe imatsatana ndi malungo imawonjezera kufunika kwa insulin. Kusintha kuchokera ku mtundu wina wa insulin kupita ku wina kuyenera kuchitika mothandizidwa ndi misempha yamagazi. Mankhwala amachepetsa kulolera kwa mowa.

Chifukwa cha kuthekera kwanyengo m'matumba ena, kugwiritsa ntchito mankhwalawa m'mapampu a insulin sikulimbikitsidwa.

Zotsatira pa kuthekera koyendetsa magalimoto ndi machitidwe oongolera Pa nthawi yoyamba kukonzekera insulin, kusintha kwa mtundu wake, kapena kupsinjika kwakuthupi kapena kwamalingaliro m'thupi, ndizotheka kuchepetsa kuyendetsa galimoto kapena kuwongolera njira zosiyanasiyana, komanso kuchita zochitika zina zowopsa zomwe zimafuna kuchuluka chidwi ndi liwiro la psychomotor zimachitikira jekeseni njira ntchito insulin mu makatiriji ndi mankhwala Biosulin N cholinga ntchito ndi cholembera cha syringe cha BiomatikPen. Wodwalayo ayenera kuchenjezedwa za kufunika kotsatira malangizo mosamala mu malangizo ogwiritsira ntchito cholembera cha syringe popereka insulin. Musanagwiritse ntchito, onetsetsani kuti palibe zowonongeka (mwachitsanzo, ming'alu) pa cartridge ndi Biosulin® N. Osagwiritsa ntchito cartridge ngati pali zowonongeka. Musagwiritse ntchito Biosulin® N ngati, mukusakaniza zomwe zili pakatoni malinga ndi malangizo ogwiritsira ntchito, insulin siyikhala yoyera komanso yamtambo. Osagwiritsa ntchito Biosulin N ngati ili ndi mapokoso mukasakaniza. Osagwiritsa ntchito Biosulin N ngati tinthu tating'ono tomwe timatengera pansi kapena makhoma a cartridge, ndikupanga "mawonekedwe achisanu". Kathumba katayikidwa mu cholembera, chingwe chautoto chiyenera kuwonekera kudzera pazenera la wonyamulira. Musanayike cartridge mu syringe cholembera, tembenuzani katoni ndikutsitsa kuti galasi la galasi lisunthe kuchokera kumapeto kupita kumapeto kwa cartridge. Njirayi iyenera kubwerezedwa nthawi 10 mpaka madzi onse atakhala oyera komanso mitambo. Zitachitika izi, jekeseni ndikofunikira. Ngati cartridge ili kale ndi cholembera, muyenera kuyitembenuza ndi cartridge mkati ndikutentha kasanu. Ndondomeko iyenera kubwerezedwa musanayambe kubayidwa aliyense. Pambuyo pa jekeseni, singano imayenera kukhalabe pansi pakhungu kwa masekondi 6 osachepera. Sungani batani kuti lipanikizidwe mpaka singano itachotsedwa kwathunthu pakhungu, ndikuwonetsetsa kuti mayendedwe olondola a mankhwalawo komanso kuthekera kwa magazi kapena zamitsempha kulowa mu singano kapena katemera wa insulin ndizochepa. Katemera ndi mankhwala a Biosulin N adapangidwira kuti azigwiritsa ntchito payekha ndipo sayenera kuzazidwanso. Njira Yogwiritsa ntchito jakisoni • Pogwiritsa ntchito zala ziwiri, sonkhanitsani khola, ikani singano m'munsi mwa khola pakatundu pafupifupi 45 °, ndikuyika insulin pansi pa khungu. • Pambuyo pakubayidwa, singano imayenera kukhalabe pansi pakhungu kwa masekondi osachepera 6 kuti muwonetsetse kuti insulini idabisidwa kwathunthu. • Ngati magazi abwera pamalo a jakisoni mutachotsa singano, pofinyani pang'onopang'ono jakisoni ndi swab yothira ndi njira yotsatsira (monga mowa). • Ndikofunikira kusintha tsamba la jakisoni.

insulin-isophan (maumboni amtundu wa anthu) 100 IU Othandizira: zinc oxide, sodium hydrogen phosphate, protamine sulfate, metacresol, crystalline phenol, glycerol, d / i madzi.

Zotsatira zoyipa za Biosulin N

Kuchokera kumbali ya kagayidwe: zinthu zam'magazi (zotupa za pakhungu, kuchuluka thukuta, palpitations, kugwedezeka, njala, kukwiya, paresthesia mkamwa, mutu). Matenda oopsa a hypoglycemia angayambitse kukula kwa chikomokere kwa hypoglycemic. Zotsatira zamatsenga: kawirikawiri - zotupa pakhungu, edema ya Quincke, nthawi zina - kuwopsa kwa anaphylactic. Zomwe zimachitika m'deralo: hyperemia, kutupa ndi kuyabwa pamalowo jekeseni, ndikugwiritsidwa ntchito kwa nthawi yayitali - lipodystrophy pamalo opaka jekeseni. Zina: edema, zolakwika zopanda kanthawi kochepa (nthawi zambiri kumayambiriro kwa mankhwala).

Kuyanjana kwa mankhwala

Pali mankhwala angapo omwe amakhudza kufunika kwa insulin.

Zotsatira za hypoglycemic za insulin zimatheka chifukwa cha mankhwala apakamwa a hypoglycemic, ma inhibitors a MAO, osagwiritsa ntchito beta-blockers, ACE inhibitors, sulfanilamides, anabolic steroids, carbonic anhydrase inhibitors, bromocriptine, octreotide, tetracyclines, kefiloflindofindindindindendendalafindalindepindepindepindepindulindindendendului, anafiloflindilindolindindendendala, pulatifindindendendala, pulatifindindindendendani, pulatifondindindindendani, ndimu. kukonzekera kokhala ndi Mowa. Mphamvu ya m`kamwa hypoglycemic ya insulin imachepetsedwa ndi kulera kwapakamwa, corticosteroids, mahomoni a chithokomiro, thiazide diuretics, heparin, tridclic antidepressants, sympathomimetics, danazole, clonidine, calcium njira blockers, diazoxide, morphine, phenytoin, nikotini.Mothandizidwa ndi reserpine ndi salicylates, kufooka komanso kuwonjezeka kwa machitidwe a mankhwalawa ndizotheka.

Mitengo ya Biosulin N m'mizinda inanso

Biosulin N ku Moscow, Biosulin N ku St. Petersburg, Biosulin N ku Novosibirsk, Biosulin N ku Yekaterinburg, Biosulin N ku Nizhny Novgorod, Biosulin N ku Kazan, Biosulin N ku Chelyabinsk, Biosulin N ku Omsk, Biosulin N ku Samara, Biosulin N ku Rostov-on-Don, Biosulin N ku Ufa, Biosulin N ku Krasnoyarsk, Biosulin N ku Perm, Biosulin N ku Volgograd, Biosulin N ku Voronezh, Biosulin N ku Krasnodar, Biosulin N ku Saratov, Biosulin N ku Tyumen Order ku Moscow

Mukamayitanitsa ku Apteka.RU, mutha kusankha kupita ku malo ogulitsa mankhwala omwe muli nawo pafupi ndi nyumba yanu kapena panjira yakunyumba.

Malo onse operekera ku Moscow - mafakitale 696

Tsiku lobwereza: Epulo 2, 2016

Werengani ndemanga yonse Yowunikiridwa ndi: Bondareva Margarita

Tsiku lobwereza: Ogasiti 1, 2016

Tsiku lobwereza: Ogasiti 19, 2016

Tsiku lobwereza: Seputembara 15, 2016

Tsiku lobwereza: February 18, 2017

Insulin Isofan yaumunthu ya anthu: kugwiritsa ntchito ndi mtengo wa mankhwalawo

Isofan ndi insulin yoyenga bwino kwambiri, yomwe imagwiritsidwa ntchito pochiza odwala omwe ali ndi matenda ashuga.

Insulin yaumunthu, yomwe imapezeka ndi ma genetic engineering omwe amagwiritsa ntchito tekinoloje ya DNA, imawerengedwa ngati mankhwala owonjezera pakatikati.

M'masitolo ogulitsa mankhwalawa, amagulitsidwa monga kuyimitsidwa komwe kumagwiritsidwa ntchito jekeseni pansi pa khungu. Mtengo umatengera mlingo, wopanga ndipo amasiyanasiyana kuchokera ku 500 mpaka 1000 rubles.

Pharmacology

Isofan - insulin, ili ndi vuto la hypoglycemic. Imalumikizana ndi malekezero apadera a membrane wakunja wa cytoplasmic cell, chifukwa chomwe insulin receptor system imapangidwa. Zimathandizira kulimbikitsa njira zamagawo.

Chifukwa chakuti kusuntha kwa glucose mkati mwa maselo kumachuluka, kuchuluka kwake m'magazi kumatsika. Zotsatira zofananazo zimatheka pochepetsa kuchuluka kwa shuga m'magazi ndikuwonjezera kuyamwa kwake ndi minofu.

Mankhwalawa amagwira ntchito kwanthawi yayitali chifukwa cha kuthamanga, komwe kumayendetsedwa ndi zinthu zingapo: momwe insulin imalowera (imatha kubayidwa m'mimba, ntchafu kapena matako), njira yoyendetsera, Mlingo.

Pambuyo pobweretsa insulle yaumunthu yopanga ma insulin pansi pa khungu ndi jakisoni, kutseguka kwake kumachitika pambuyo pa ola limodzi ndi theka. Mankhwalawa amagwira ntchito kwambiri kuyambira 4th mpaka 12 koloko, amagwira ntchito masana.

Zinthu zotsatirazi zitha kuchitika chifukwa cha zofunikira za Isofan: samakhazikika mkaka wa amayi. Kugawa mu minofu sikofanana. Samadutsa placenta. Kuyambira 30 mpaka 80% amachotseredwa ndi impso.

Malangizo ogwiritsira ntchito

Malangizo ogwiritsira ntchito amawunikira mtundu waukulu wamatenda omwe ma insulin omwe amapangidwira matendawa amagwiritsidwa ntchito - insulin yodalira matenda a shuga. Chithandizo mu izi zimachitika mu moyo wonse. Pankhaniyi, ndikofunikira kutsatira jakisoni. Kuphatikiza apo, Isofan imagwiritsidwa ntchito pa mtundu 1 ndi matenda ashuga 2.

Dokotala atha kukulemberani mankhwala ngati pali vuto kuchokera ku mankhwala omwe amachepetsa shuga. Kenako insulin imayikidwa ngati mankhwala osakaniza.

Kuwonjezeka kwa shuga m'magazi kungakhale chifukwa chazovuta, mwachitsanzo, pambuyo pakuchita opaleshoni. Pankhaniyi, insulin ikhoza kutumikiranso ngati chithandizo chovuta. Amalandira amayi apakati omwe ali ndi matenda ashuga.

Isofan imagwiritsidwa ntchito kokha pa mtundu 1 ndi matenda ashuga 2!

Mankhwalawa amadziwikiridwa kwa odwala omwe amatha kuyanjana ndi hypoglycemia.

Kutengera mphamvu

Zotsatira zoyipa za kutenga Isofan ndi:

Zotsatira zoyipa za kagayidwe kazakudya. Izi zikuwonetsedwa ngati mawonekedwe amkhungu pakhungu, thukuta kwambiri, kuthamanga mtima, mawonekedwe a kunjenjemera, munthu amafunitsitsa kudya, amakhala ndi chisangalalo chamanjenje, kupweteka kwa mutu pafupipafupi.
Chiwonetsero chofotokozedwa ndi zotupa pakhungu, edema ya Quincke. Nthawi zina, mankhwalawa amayambitsa anaphylactic.
Kutupa kumatha kuchitika.
Pambuyo jakisoni, kuyabwa kapena kutupa, kupweteka kumatha kuchitika. Ngati chithandizo cha mankhwala chimatenga nthawi yayitali, lipodystrophy imapangidwa.

Pankhani imeneyi, kumayambiriro kwa chithandizo, chithandizo cha insulin chitha kuchitika pokhapokha poikidwa ndi dokotala komanso moyang'aniridwa.

Mlingo wowonjezera

Pankhani ya kuyambitsa kuchuluka kwa mankhwala, wodwalayo amatha kuwona zizindikiro za hypoglycemia. Poterepa, muyenera kudya chidutswa cha shuga kapena zakudya zopatsa mphamvu yamafuta ambiri. Itha kukhala ma cookie, madzi a zipatso, maswiti.

Kuyambitsa Isofan kwambiri kungachititse kuti musamale kwambiri. Ndikulimbikitsidwa kuti mupeze jakisoni wambiri wa 40% dextrose solution. Glucagon imatha kutumikiridwa intramuscularly, kudzera m'mitsempha kapena mozungulira.

Njira zopewera kupewa ngozi

Mukamagwiritsa ntchito ISofan, ziyenera kukumbukiridwa kuti ngati mutabaya mankhwalawo pamalo omwewo, lipodystrophy imatha kupanga. Popewa, tikulimbikitsidwa kusintha tsamba la jakisoni. Mukamapangira mankhwala a insulin, muyenera kuyang'anira shuga wanu wamagazi.

Chipangizocho chikuyenera kuvulazidwa mothandizidwa ndi adokotala. Kupanda kutero, hypoglycemia ikhoza kukhala. Itha kuwoneka chifukwa cha zakudya zomwe sizinachitike. Pankhaniyi, munthu amakhala ndi ludzu, pakamwa pouma, kukokana pafupipafupi, kusakhala bwino ndi thanzi, mpaka kusanza, kusowa kwa chilimbikitso, kupuma koipa kwa asetone kuchokera mkamwa.

Mankhwala omwe amayendetsedwa azikhala opanda matupi achilendo, owonekera, osagwa pansi. Kukhalapo kwake kumawonetsa kuwopsa kwa insulin, chifukwa chake kugwiritsa ntchito mankhwalawa kungakhale koopsa kwa wodwala.

Isophan izikhala yoyenera kutentha pakaperekedwa. Ndi matenda opatsirana omwe amapezeka chifukwa cha kukanika kwa chithokomiro, Hypopituitarism, kuchuluka kwa mankhwala omwe amaperekedwa amafunika kusintha.

Isofan imayikidwa ndi dokotala ngati palibe zotsatira zamankhwala ndi mankhwala ochepetsa shuga.

Kuchita zamtanda

Malangizo ogwiritsira ntchito mankhwalawa amafotokozera mwatsatanetsatane mawonekedwe a mankhwalawo komanso mawonekedwe ake ogwiritsira ntchito.

Kapangidwe kamtundu wamtundu wa Isofan ndikogwira ntchito ngati mankhwala otsatirawa atengedwa nthawi yomweyo:

Hypoglycemic pamlomo wothandizira.
Mao ndi ACE zoletsa, carbonic anhydrase.
Sulfonamides.
Anabolikov.
Tetracyclines.
Mankhwala okhala ndi ethanol.

Mphamvu ya Isofan imachepa ndikugwiritsira ntchito: Kulera kwapakamwa, mankhwala a glucocorticoid, mahomoni a chithokomiro, antidepressants, morphine. Ngati sizotheka kusiya mankhwala omwe amakhudza insulin, ndikofunikira kuchenjeza adokotala omwe akupezekapo.

Mankhwala ofanana

Odwala a shuga ali ndi chidwi chofunsa funso lomwe limatanthawuza insulin. Ndikulimbikitsidwa kugwiritsa ntchito fanizo lotsatira la Isofan pochiza: Humulin (NPH), Protafan-NM, Protafan-NM Penfill, Insumal, Actrafan.

Musanasinthe Isofan kukhala analog, ndikofunikira kufunsa dokotala. Mankhwala a insulin ndi chithandizo chachikulu. Zimafunikira kulangidwa ndi wodwalayo komanso zomwe dokotala akuwona.

Matenda a shuga ndi matenda oopsa, omwe, mwatsoka, sangathetsedwe konse. Monga mukudziwa, motsutsana ndi kudwala, pali kuphwanya kwa katulutsidwe ka mahomoni mu tiziwalo ta kapamba. Ndipo nthawi zambiri, odwala amapatsidwa insulin yopanga insulin. Izi zimawongolera kuchuluka kwa shuga m'magazi, kuonetsetsa kuti thupi lonse limagwira.

Zachidziwikire, odwala ali ndi chidwi chofuna kudziwa chilichonse chokhudza mankhwalawo. Kodi insulin Isofan imakhudza bwanji thupi? Malangizo, contraindication, zovuta zomwe zingachitike panthawi ya mankhwala ndizofunikira zomwe zimakambidwa m'nkhaniyi.

Kutulutsa Fomu

Si chinsinsi kuti matenda ashuga ndiofala komanso owopsa omwe amafuna kugwiritsa ntchito mankhwala osiyanasiyana, kuphatikizapo insulin.

"Isofan" ndi dzina lamalonda lamankhwala, lomwe ndi mankhwala osakanikira opangidwa ndi mahomoni amiseche. Mankhwala amapangidwa ngati njira yothetsera ma subcutaneous makonzedwe.

Mankhwala amagulitsidwa m'mabotolo agalasi a 10 ml ndi mlingo wa 40 IU / ml. Kukonzekera yankho, madzi oyeretsedwa a jakisoni amagwiritsidwa ntchito.

Ngati mankhwala ena omwe ali ndi mawonekedwe omwewo ndi insulin Isofan. Zofananira zake ndi "Insuman", "Protafan" ndi "Himulin". M'pofunika kunena nthawi yomweyo kuti mankhwalawa amaperekedwa pokhapokha kuti apatsidwe mankhwala kapena amathandizidwa ndi endocrinologist.

Kodi mankhwalawo ali ndi katundu wotani?

Insulin "Isofan" ndi mahomoni opanga omwe ali ndi zinthu zofanana ndi zomwe zimapangidwa ndi kapamba wamunthu. Mankhwalawa amachepetsa kuchuluka kwa shuga m'magazi mwa kupititsa patsogolo machitidwe a lipogenesis ndi gluconeogeneis.

Ma synthetoni mahomoni amayanjana ndi ma insulin omwe amadalira maselo, ndikuyambitsa metabolic mkati mwa cell. Mutatha kumwa mankhwalawa, pali mphamvu ya kapangidwe ka michere ina, kuphatikizapo glycogen synthetases, pyruvate kinases ndi hexokinases.

Zotsatira zitha kuonedwa kale maola 1-1.5 pambuyo pokhazikitsa yankho. Kutengera mlingo ndi mawonekedwe a thupi la wodwalayo, pazinthu zambiri zomwe amapanga insulin zimawonedwa patangotha maola 4-12 atatha kutsata. Zotsatira zake zimatenga maola 11 mpaka 24.

Zizindikiro zazikulu zogwiritsidwa ntchito

Mankhwala "Insulin-Isofan" amagwiritsidwa ntchito pa matenda a shuga a mtundu wachiwiri (fomu yodalira insulin). Amagwiritsidwanso ntchito pochiza insulin. Nthawi zina chithandizo choterechi chimafunikanso kwa matenda amtundu 1. Mwachitsanzo, kuyambitsidwa kwa yankho kumalimbikitsidwa kwa odwala milandu pomwe mankhwala omwe amachepetsa shuga samapereka zomwe akufuna.

Kukhazikitsidwa kwa insulin yaumunthu kumafunika pambuyo pa njira zina zopangira opaleshoni. Mankhwalawa amagwiritsidwanso ntchito pothana ndi matenda a shuga (matenda amtunduwu amayamba mwa amayi nthawi yapakati). Kukhazikitsidwa kwa insulin kwa amayi oyembekezera kumalimbikitsidwa ngati chithandizo chamankhwala sichikhala nacho chofunikira.

Semi-kupanga insulin "Isofan": malangizo ogwiritsira ntchito

Ndi matenda 2 a shuga, odwala amafunikira chithandizo cha moyo wonse. Mlingo, tsiku lililonse, dongosolo la oyang'anira - zonsezi zimatsimikiziridwa ndi kupezeka kwa endocrinologist. Ndikofunikira kutsatira mosamalitsa malangizo onse a katswiri. Pali malamulo ena wamba ogwiritsira ntchito Insulin-Isofan.

Njira yothetsera vutoli ndi yokhayo yopanga makina osokonekera. Nthawi zina, dokotala angalimbikitse kupereka mankhwalawa intramuscularly. Jekeseni wamkati amuloledwa.
Mankhwalawa sangathe kutumikiridwa pamalo omwewo.
Choyamba muyenera kugwedeza botolo kangapo, kenako ndikokerani kuchuluka kwa yankho mu syringe (mlingo umasankhidwa).
Jakisoni amayenera kuchitidwa nthawi yomweyo mutadzaza syringe.

Mbale zokhala ndi vutoli zimasungidwa mufiriji pamtunda wa 2-8 digiri Celsius. Musanapereke mankhwalawa, muyenera kuyeza kuchuluka kwa shuga m'magazi. Palibe chifukwa muyenera kugwiritsa ntchito mankhwalawa ngati muona yankho lamtambo, mapangidwe a mpweya m'makoma a botolo.

Kodi pali zotsutsana?

Mankhwala ali ndi zotsutsana zina - izi zimakhala ndi malangizo ogwiritsira ntchito. "Insulin-Isofan" sinafotokozedwe kwa odwala omwe ali ndi hypoglycemia.

Contraindication imaphatikizapo insulinoma, komanso hypersensitivity pazigawo zamankhwala.

Ndizofunikira kudziwa kuti nthawi zina ngakhale kusintha kwa jakisoni kumatha kubweretsa zovuta zonse komanso kuwonekera kwa zotsatirapo zina.

Zotsatira zoyipa

Mankhwalawa ndiofunikira kwa odwala omwe ali ndi mitundu yodwala ya shuga. Komabe, chithandizo chamankhwala chimakhudzana ndi zovuta zina. Ndi zolakwika ziti zomwe zingayambitse kugwiritsa ntchito Isofan-Insulin? Malangizowa ali ndi izi:

Mndandanda wamatenda omwe amadziwika kwambiri amatha kuphatikizira zomwe zimachitika, zomwe zimayendera limodzi ndi mawonekedwe a zotupa ndi urticaria, kutsika kwamphamvu kwa kuthamanga kwa magazi, kuwonjezeka kwa kutentha kwa thupi komanso mawonekedwe a edema.
Zotsatira zowopsa za insulin mankhwala ndi hypoglycemia, mkhalidwe womwe umadziwika ndi kuchepa kwa shuga m'magazi. Zizindikiro zimaphatikizira khungu, kuthamanga kwamtima, nkhawa, kugona movutikira, kumangokhala ndi njala. Kuphwanya koteroko nthawi zambiri kumagwirizanitsidwa ndi Mlingo wosayenera kapena osagwirizana ndi malangizo a dokotala. Vuto lalikulu kwambiri limayamba.
Kuyamba kulandira chithandizo mwa odwala kumalumikizidwa ndi kuwonongeka kwa mawonekedwe. Sikoyenera kuda nkhawa kwambiri ndi izi, chifukwa nthawi zambiri zotsatirapo zoyipa zimangokhala zokha.
Mndandanda wazovuta zomwe umaphatikizidwa umaphatikizidwa ndi zochita za immunological, zomwe zimadutsanso m'mene thupi limasinthira mtundu uwu wa insulin.
Kumayambiriro kwa kumwa mankhwalawa, zimachitika pakhungu, kuphatikiza redness ndi kuyabwa. Amadutsa okha.
Kukhazikitsidwa kwa Mlingo waukulu kwambiri wa mankhwalawa kumadzaza ndi mavuto amisala. Kuchulukirachulukira, nkhawa, kusintha kwa machitidwe, kakulidwe ka kukhumudwa kumadziwika.

Ndikofunika kumvetsetsa kuti Isofan insulin iyenera kuperekedwa molingana ndi dongosolo lomwe dokotala wakupanga. Kudumpha jakisoni kumayendera limodzi ndi kukula kwa matenda ashuga.

Mankhwala amakono, ma insulin opangidwa ndi anthu (kufupikitsidwa kwakanthawi ndi kwapakatikati), ma analogu a mahomoni aumunthu, ndi zosakaniza zimagwiritsidwa ntchito kuwongolera kuchuluka kwa shuga. Inde, msika wogulitsa mankhwala umapereka mankhwala ambiri omwe amathandizira kuthetsa kwakanthawi zizindikiro za matenda ashuga.

Pamndandanda wa analogues mulinso mankhwala monga "Actrafan", "Biogulin", "Diafan". Nthawi zina, odwala amalimbikitsidwa kuti akonzekere "Protafan", "Humodar", "Pensulin". Bazal ndi Fereyn wa insulin nawonso amatengedwa kuti ndiabwino.

Tiyenera kumvetsetsa kuti mahomoni ndi mankhwala oopsa, ndipo simungathe kuwagwiritsa ntchito mwanjira iliyonse. Ndi dokotala yekhayo amene angasankhe analog ndikuzindikira kuti ndi ndani.

Mwachitsanzo, kupezeka kwa kachulukidwe kamodzi mu yankho mwa odwala ena kumatha kuyambitsa mavuto ambiri omwe amabwera chifukwa cha anaphylactic.

Zidziwitso zina zogwirizana ndi mankhwala

Musanayambe chithandizo, muyenera kudziwitsa dokotala zamankhwala omwe mukumwa. Kuchita kwa insulin yopanga kumapangidwira pamene mukumutenga ndi sulfonamides, hadrogens ndi anabolic steroids, ma inhibitors a MAO, omwe si a antiidal.

Mphamvu ya hypoglycemic imatchulidwa motsutsana ndi kugwiritsidwa ntchito kwakanthawi kofanana ndi mankhwala a Isofan okhala ndi ketoconazole, cyclophosphamide, quinine, chloroquinine, quinidine, ndi mankhwala okhala ndi lithiamu.

Mwa njira, siyikulimbikitsidwa kumwa mowa panthawi ya mankhwala, popeza Mowa umapititsa patsogolo mphamvu ya kupanga insulin.

Estrogens, njira zakulera zamkamwa, glucagon, heparin, mahomoni a chithokomiro amachepetsa mphamvu ya mankhwalawa. Zomwezi zitha kunenedwa za nikotini, chamba, morphine, ma diuretics (makamaka, thiazide ndi loop), antidepressant atatu.

Mulimonsemo, ziyenera kumvetsedwa kuti popanda chidziwitso cha dokotala, simungasinthe mlingo kapena ndandanda ya insulin. Maonekedwe akuipiraipira komanso oyipa amayenera kudziwitsidwa kwa endocrinologist.

Isofan insulin: malangizo ogwiritsira ntchito komanso mtengo wa mankhwalawa

Chithandizo cha insulin chimakhala ndi mawonekedwe ena, chifukwa ntchito yayikulu yothandizira pakubwezerera kwa malfunctions mu carbohydrate metabolism pakubweretsa mankhwala apadera pansi pa khungu. Mankhwala oterowo amakhudza thupi komanso insulini yachilengedwe yopangidwa ndi kapamba. Pankhaniyi, mankhwalawa amakhala athunthu kapena osapatula.

Mwa mankhwala omwe amagwiritsidwa ntchito popanga matenda ashuga, imodzi mwabwino ndi insulin Isofan. Mankhwala ali ndi chibadwa chomanga insulin ya nthawi yayitali.

Chidachi chimapezeka m'njira zosiyanasiyana. Amayendetsedwa m'njira zitatu - subcutanely, intramuscularly komanso kudzera m'mitsempha. Izi zimathandiza wodwala kusankha njira yabwino kwambiri yolamulirira glycemia.