Mndandanda wa mankhwala langerin

Langerin ndi imodzi mwazamankhwala ambiri omwe amagwiritsidwa ntchito pochiza matenda a matenda a shuga omwe samatengera insulin. Mankhwalawa ndi gawo la gulu la mankhwala a greatuanide, zotsatira zake zazikulu ndikuchepetsa kufunikira kwa kupanga insulini.

Mtengo wa Langerin m'masitolo ogulitsa, kutengera mlingo womwe ungafunike, ukhoza kuchokera ku ruble zana limodzi mpaka mazana atatu.

Langerin ndi mankhwala apiritsi a pakamwa omwe amagwiritsidwa ntchito pochiritsira matenda a shuga. Gawo lake lalikulu ndi mankhwala a metformin. Mankhwalawa ndi amodzi mwa mankhwala ochepetsa shuga ndipo nthawi zambiri amagwiritsidwa ntchito kuti matenda ashuga azikhala ndi matenda ashuga.

Chimodzi mwazomwe mungafotokozere za mankhwalawa ndi kukhazikitsidwa kwake ngati mapiritsi omwe amagwiritsidwa ntchito kale kuchokera ku gulu la sulfonylurea. Kuphatikiza apo, kunenepa kwambiri ndi vuto lolumikizana kwa anthu onse omwe ali ndi matenda ashuga.

Chifukwa chake, Langerin samangoleketsa kuchuluka kwa shuga, komanso zimathandizira kuti wodwalayo achulukane.

Katundu wama mankhwala ndi zizindikiro zogwiritsira ntchito

Kupanga kwa gawo lalikulu la mankhwala kumalumikizidwa ndi mphamvu yake yoletsa njira za gluconeogeneis, komanso njira za kaphatikizidwe wamafuta acids amafuta ndi oxidation wamafuta. Woimira kalasi la Biguanide samakhudza kuchuluka kwa insulin yomwe imatulutsidwa m'magazi, koma amasintha ma pharmacodynamics awo mwa kuchepetsa kuchuluka kwa insulini kumasulidwa ndikuwonjezera kuchuluka kwa insulini kuti proinsulin.

Chofunikira pakuwoneka kwa mapiritsi oterewa ndi kukondoweza kwa glucose omwe amapezeka m'maselo a minofu.

Chizindikiro chachikulu chogwiritsira ntchito mankhwalawa ndikutukuka kwa matenda a shuga omwe amadalira insulin mwa munthu, makamaka ndi kusakwanira kwa zakudya zomwe amatsata.

Mankhwala enieni a Langerin ndi awa:

• amachepetsa kuchuluka kwa hemoglobinꓼ ya glycated
• saiziwalitsa kukana kwa insulini m'maselo kupita ku ma insulin a insulin
• zimakhudza kutengera kwa mawonekedwe a lipid a plasmaꓼ
• amachepetsa cholesterolꓼ yoyipa

Kuphatikiza apo, kugwiritsa ntchito mankhwalawa kumatha kulimbitsa thupi.

Malangizo ogwiritsira ntchito mapiritsi

Mankhwala Langerin amapezeka mu mawonekedwe a mapiritsi okhala ndi tulo.

Mapiritsiwo amadzaza ndi thumba la pulasitiki, lomwe limasindikizidwa ndi zojambulazo za aluminiyamu.

Mapaketi amaikidwa pabokosi la makatoni pamodzi ndi malangizo ogwiritsira ntchito mankhwalawa.

Kutengera kuchuluka kwa mankhwalawa omwe agwiritsidwa ntchito, mankhwalawa atha kugulidwa ndi mlingo wa:

1. Ma milligram 500.
2. Ma milligram 850.
3. Gramu imodzi yogwira ntchito.

Njira yothetsera mapiritsiwa imakhala pakumwa, panthawi yakudya kapena itatha. Dotoloyo akupereka mankhwala kwa wodwala aliyense payekha malinga ndi kuopsa kwa matendawa. Komanso, katswiri wazachipatala amazindikira kuchuluka kwa mankhwalawa tsiku lililonse masana.

Langerin-malangizo angagwiritsidwe ntchito amalimbikitsa kuyambitsa njira yochiritsira yochepetsera ndi osachepera 500 mg a yogwira ntchito. Kuchuluka kwa Mlingo wa mankhwalawa masana kungakhale kwa mmodzi kapena atatu. Pang'onopang'ono, mlingo ungathe kuwonjezeka mpaka 850 mg wa chinthu chogwira tsiku lonse (kamodzi kawiri pa tsiku). Dokotala wothandizirayo amawunikira wodwalayo ndipo osapitirira kamodzi pa sabata, amasintha mlingo wa mankhwalawo.

Mankhwalawa adapangidwanso zochizira matendawa ana opitirira zaka khumi. Monotherapy iyenera kuyamba ndi mlingo wa 500 mg yogwira ntchito kamodzi kapena kawiri pa tsiku. Pakapita kanthawi, kuwonjezeka kwapang'onopang'ono kwa mlingo wa mankhwalawa amaloledwa, koma osaposa magalamu awiri patsiku, omwe amagawidwa pawiri kapena katatu.

Nthawi zambiri, kusintha kwa muyezo wa mankhwalawa kumachitika pakatha masiku khumi mpaka khumi ndi asanu potengera zotsatira za kuyezetsa magazi pamlingo wama glucose.

Nthawi zina, kuphika piritsi ndi gawo limodzi la mankhwala ophatikiza ndi jakisoni wa insulin.

Tiyenera kudziwa kuti munthawi yomweyo mankhwala a Langerin omwe ali ndi insulin, zotumphukira za sulfonylurea, acarbose, kapena ACE inhibitors amadziwika kuti amawonjezera mphamvu ya hypoglycemic ya mankhwala.

Nthawi zina, dokotala yemwe amapezekapo akhoza kusintha kugwiritsa ntchito Langerin ndi mapiritsi ofanana. Masiku ano, pali mitundu yambiri ya mankhwala, omwe amagwiritsidwa ntchito kwambiri ndi metformin.

Mtengo wa mankhwala a analog ukhoza kusiyana kwambiri, kutengera kampani yopanga mankhwala.

Kodi zotsutsana ndizogwiritsa ntchito chiyani?

Mlingo wosankhidwa molakwika kapena kusatsatira malangizo a dokotala kungakupangitseni kuoneka ngati musanamwe mankhwala.

Kuphatikiza apo, pali zochitika zina komwe kugwiritsa ntchito mankhwala ozungulira metformin ndikoletsedwa.

Malangizo ogwiritsira ntchito mankhwalawa akuwonetsa mndandanda wazotsatira zazikulu.

Milandu yayikulu pakugwiritsa ntchito mapiritsi a Langerin ndi awa:

• kuwonongeka kwakukulu kwa chiwindi kapena impso, kusakwanira kwawo
• uchidakwa, kuphatikiza pamakhalidwe oyipaꓼ
• mtima kapena kupuma
• pachimake myocardial infarctionꓼ
• mkhalidwe wodwala matenda ashuga kapena kholo
• chitukuko cha matenda ashuga phaziꓼ
• pamaso pa tsankho la munthu ndi metformin komanso kusintha kwa zinthu zina zosagwirizana ndi gawoꓼ
• kukhalapo kwa matenda opatsirana infectious
• kusala ndi matenda ashuga kapena kutsatira zakudya zomwe zakudya zake za tsiku ndi tsiku siziposa kilocaloriesꓼ
• Opaleshoni isanachitike komanso itachitika
• ndimavulala azambiri recent
• isanachitike komanso itatha diagnostic omwe amagwiritsa ntchito radio isotropes ya iodineꓼ
• ketoacidosis ndi lactic acidosis.

Kuphatikiza apo, azimayi sayenera kumwa mankhwalawa panthawi yoyembekezera komanso mkaka wa m'mawere.

Kupezeka kwa zoyipa kumatha kudziwonekera mwa mbali zosiyanasiyana za thupi ndi machitidwe a thupi - m'mimba thirakiti, kagayidwe kazinthu, mtima dongosolo, khungu. Zoyipa zazikulu zomwe zimachitika chifukwa ch kumwa mankhwalawa ndi:

1. Kukweza mwachangu. Nthawi zina mseru umapezeka mu mtundu 2 shuga. Khansa ya m'mimba ikhoza kulowa m'malo mwa kusanza.
2. Mtundu wopweteka wam'mimba.
3. Maonekedwe akununkhira wachitsulo pamkamwa wamkamwa.
4. Hematopoiesis ndi heestasis.
5. Megaloblastic anemia.
6. Kutsitsa shuga m'magazi pansi pazovomerezeka - hypoglycemia.
7. Maonekedwe ofooka m'thupi.
8. Kugona.
9. Hypotension.
10. Matenda opatsirana.
11. Maonekedwe a dermatitis kapena totupa pakhungu.

Chenjezo liyenera kumwedwa mukamamwa Langerin ndi mankhwala ena. Kugwiritsa ntchito pamodzi mapiritsi ndi cymeditine kumawonjezera chiopsezo cha lactic acidosis. Kuphatikiza kwa Langerin ndi ma loopture otentha kumatha kukhala ndi zotsatira zomwezo. Pankhaniyi, kuwonjezera pakuwonetsedwa kwa lactic acidosis, chiwonetsero cha kulephera kwa impso chitha kuonedwa.

Kugwiritsa ntchito mankhwalawa, ndikofunikira kuyang'anira momwe impso zimagwirira ntchito ndikuwonetsa kuchuluka kwa lactate mu plasma osachepera kawiri pachaka.

Zambiri zokhudzana ndi mankhwala omwe amagwiritsidwa ntchito pochiza matenda a shuga zimaperekedwa mu kanema munkhaniyi.

Kufotokozera za mankhwalawa

Langerine - Wochita pakamwa hypoglycemic ku gulu la Biguanides (dimethylbiguanide). Kupanga kwa zochita za metformin kumalumikizidwa ndi kuthekera kwake kuponderezera gluconeogeneis, komanso mapangidwe a mafuta achilengedwe omasuka ndi makulidwe a oxidation. Zimawonjezera chidwi cha zotumphukira zolandilira ku insulin ndikugwiritsa ntchito shuga ndi maselo. Metformin siyimakhudzanso kuchuluka kwa insulin m'magazi, koma imasintha ma pharmacodynamics pochepetsa kuchuluka kwa insulini kuti imasulidwe ndikuwonjezera kuchuluka kwa insulin kuti proinsulin.

Metformin imathandizira kapangidwe ka glycogen pochita pa glycogen synthetase. Kuchulukitsa kuthekera kwamitundu yonse yamtundu wama glucose oyenda. Kuchepetsa mayamwidwe m'matumbo.

Lowers triglycerides, LDL, VLDL. Metformin imakweza michere yamagazi ya fibrinolytic mwa kuponderezana ndi minyewa yotulutsa minyewa ya plasminogen activator inhibitor.

Ngakhale mutatenga Metformin, thupi la wodwalayo limakhalabe lolimba kapena limatsika pang'ono.

Mndandanda wazofananira

Zolemba zosangalatsa

Momwe mungasankhire analog yoyenera
Mu pharmacology, mankhwala nthawi zambiri amagawidwa m'magulumagulu ndi ma analogi. Kapangidwe kazofananira kameneka kamaphatikizira amodzi kapena angapo amomwe omwewo omwe ali ndi mphamvu yothandizira thupi. Ndi ma analogi amatanthauza mankhwala okhala ndi zinthu zosiyanasiyana zogwira ntchito, koma zochizira matenda omwewo.

Kusiyana pakati pa matenda a ma virus ndi bakiteriya
Matenda opatsirana amayambitsidwa ndi ma virus, mabakiteriya, bowa ndi protozoa. Njira ya matenda oyambitsidwa ndi ma virus ndi ma bacteria nthawi zambiri imakhala yofanana. Komabe, kusiyanitsa chomwe chimayambitsa matendawa kumatanthauza kusankha njira yoyenera yomwe ingathandize kuthana ndi misala komanso sikuvulaza mwana.

Matalala ndi omwe amayambitsa chimfine
Anthu ena amadziwa zomwe zimachitika nthawi zambiri ngati mwana ali ndi chimfine. Makolo amamutengera kwa madotolo, kukamuyeza mayeso, kugwiritsa ntchito mankhwala osokoneza bongo, ndipo monga chotulukapo chake, mwana amalembetsa kale ndi dotolo wa ana monga nthawi zambiri amadwala. Zoyambitsa zenizeni za kupuma pafupipafupi sizidziwika.

Urology: mankhwalawa a chlamydial urethritis
Chlamydial urethritis nthawi zambiri imapezeka pochita urologist. Amayamba chifukwa cha majeremusi a chlamidia trachomatis, omwe ali ndi mphamvu ya mabakiteriya komanso mavairasi, omwe nthawi zambiri amafunikira njira yothandizira antibacterial. Imatha kuyambitsa kutupa kosakhudzana ndi urethra mwa amuna ndi akazi.

Langerin - malangizo, ntchito, ndemanga

Tsambali limapereka chidziwitso chokhudza mankhwalawa Langerin - malangizo amaperekedwa mukutanthauzira kwaulere. Kuti mumve zambiri, chonde onani zomwe akupanga. Malangizo omwe akupezeka a mankhwalawa si chifukwa chodzidziwira nokha.

Opanga: Zentiva a.s (Slovak Republic)

Zinthu zogwira ntchito
Gulu la matenda

• Matenda a shuga osagwirizana ndi insulin

Zachipatala ndi gulu la mankhwala

• Zosatchulidwa. Onani malangizo

Zotsatira za pharmacological
Gulu la mankhwala

• Kupanga kwa Hypoglycemic ndi othandizira ena pakuphatikizika

Kutulutsa mawonekedwe a Langerin

Mapiritsi 500 okhala ndi mafilimu, blister pack 10 pack of boardboard 6 pack, 500 mg-film-coated mapiritsi, blister pack 10 pack 10 of boardboard 3, 500 mg film-coated mapiritsi, blister pack 10 pack of Cardboard 9, mapiritsi, 850 mg film-yokutira, blister pack 10 pack ya makatoni 6, mapiritsi, 850 mg film-yokutira paketi, 850 mg film blister pack, 10 paketi yamakatoni 3, mapiritsi okhala ndi filimu 850 mg, blister paketi 10 paketi yamakatoni 9, mapiritsi okhala ndi kanema wovindikira 1 g, blister pack 10 pack of boardboard 1, mapiritsi okhala ndi filimu yopanda 1 g, blister packing 10 pack ofboardboard 3, mapiritsi okhala ndi filimu ya ganda 1 g, blister pack 10 Phukusi la makatoni 9,

mapiritsi okutidwa ndi filimu yophimba 1 g, matuza akuyika ma pack 10 makatoni 6,

Mankhwala

Kuchepetsa kuchuluka kwa shuga (pamimba yopanda kanthu ndikatha kudya) m'magazi komanso kuchuluka kwa hemoglobin ya glycosylated, kumakulitsa kulolera kwa glucose. Imachepetsa kuyamwa kwamatumbo a glucose, kapangidwe kake m'chiwindi, kumapangitsa chidwi cha insulini mu zotumphukira za minofu (kutulutsa kwa glucose ndikuwonjezeka kwa kagayidwe kake).

Sisintha katulutsidwe ka insulin ndi maselo a beta a pancreatic islets (kuchuluka kwa insulini poyesedwa pamimba yopanda kanthu komanso kuyankha kwa insulin tsiku lililonse kumatha kuchepera).

Imasinthasintha mawonekedwe a lipid a madzi am'magazi mwa odwala omwe samadalira insulin; amachepetsa zomwe zili ndi triglycerides, cholesterol ndi LDL (zotchulidwa pamimba yopanda kanthu) ndipo sasintha kuchuluka kwa lipoproteins a zovuta zina. Imakhazikika kapena kuchepetsa thupi.

Pharmacokinetics

Amamwa mwachangu kuchokera mumimba. Mtheradi bioavailability (pamimba yopanda kanthu) ndi 50-60%. Cmax mu plasma imatheka pambuyo maola 2. Kudya otsika Cmax ndi 40% ndikuchepetsa kukwaniritsa kwake ndi mphindi 35.

Kuchulukana kwa metformin m'magazi kumafikira mkati mwa maola 24-48 sikupitirira 1 μg / ml. Kuchuluka kwa magawidwe (kwa mlingo umodzi wa 850 mg) ndi (654 ± 358) l. Pang'onopang'ono mapuloteni a plasma, amatha kudziunjikira tiziwalo timene timataya, chiwindi ndi impso.

Imafufutidwa ndi impso (makamaka mwa kubisala kwa tubular) yosasinthika (90% patsiku). Renal Cl - 350-550 ml / mphindi. T1 / 2 ndi 6.2 h (plasma) ndi 17.6 h (magazi) (kusiyana ndi chifukwa cha kuthekera kopanga ma cell ofiira amwazi).

Mu okalamba, T1 / 2 imatenga nthawi yayitali ndipo Cmax imachulukirachulukira. Ngati vuto la impso, kusungunuka kwa T1 / 2 kumachepetsa.

Pa nthawi ya chithandizo ayenera kusiya kuyamwitsa.

Contraindication

Hypersensitivity, matenda a impso, kapena kulephera kwa aimpso (creatinine woposa 0.132 mmol / L mwa amuna ndi 0.123 mmol / L mwa akazi), kukanika kwambiri kwa chiwindi, mikhalidwe yoyendetsedwa ndi hypoxia

mtima ndi kupuma, pachimake gawo la kuchepa kwa magazi m'mimba, kuchepa kwa magazi, kuchepa magazi, matenda opatsirana, zochitika zambiri ndi kuvulala, uchidakwa, matenda amisala kapena matenda a metabolic kapena kuperewera, mbiri ya lactic acidosis kutsatira zakudya zochepa zama calorie (zosakwana 1000 kcal / tsiku), kafukufuku wogwiritsa ntchito ayodini wa ayodini, mimba, kuyamwitsa.

Zotsatira zoyipa

Kuchokera m'mimba thirakiti: kumayambiriro kwa mankhwalawa - anorexia, kutsegula m'mimba, kusanza, kusanza, kupweteka kwam'mimba (kutsika ndi chakudya), kulawa kwazitsulo mkamwa (3%).

Kuchokera kumbali ya mtima ndi magazi (hematopoiesis, hemostasis): mwanjira zina - megaloblastic anemia (chifukwa cha malabsorption a vitamini B12 ndi folic acid).

Kuchokera kumbali ya kagayidwe: hypoglycemia, nthawi zina - lactic acidosis (kufooka, kugona, kuperewera, kupweteka kwa bradyarrhythmia, kupuma, kupweteka kwam'mimba, myalgia, hypothermia.

Kuchokera pakhungu: zotupa, dermatitis.

Kuchita ndi mankhwala ena

Mphamvu ya metformin imafooketsedwa ndi thiazide ndi ma diuretics ena, corticosteroids, phenothiazines, glucagon, mahomoni a chithokomiro, estrogens, kuphatikizapo monga gawo la njira zakulera zamkamwa, phenytoin, nikotini acid, sympathomimetics, calcium antagonists, isoniazid.

Mlingo umodzi mu odzipereka athanzi, nifedipine kuchuluka kwa mayamwa, Cmax (20%), AUC (9%) metformin, Tmax ndi T1 / 2 sizinasinthe. Mphamvu ya hypoglycemic imapangidwira ndi insulin, zotumphukira za sulfonylurea, acarbose, NSAIDs, Mao inhibitors, oxytetracycline, zoletsa za ACE, clofibrate zotumphukira, cyclophosphamide, beta-blockers.

Kafukufuku wokhudzana ndi kugwiritsidwa ntchito kwa mlingo umodzi mwa odzipereka athanzi kunawonetsa kuti furosemide imachulukitsa Cmax (ndi 22%) ndi AUC (mwa 15%) ya metformin (popanda kusintha kwakukulu kwachidziwitso cha metformin), metformin imachepetsa Cmax (mwa 31%), AUC (pofika 12) %) ndi T1 / 2 (32%) ya furosemide (popanda kusintha kwakukulu kwa chilolezo cha furosemide).

Palibe deta pakukhudzana kwa metformin ndi furosemide ndikugwiritsa ntchito nthawi yayitali. Mankhwala osokoneza bongo (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren ndi vancomycin) omwe amapezeka mu mpikisano wolimbana ndi machitidwe ogwiritsira ntchito ma tubular ndipo, ndi chithandizo chambiri, amatha kuonjezera Cmax ya metformin ndi 60%.

Cimetidine amachepetsa kuchotsedwa kwa metformin, yomwe imawonjezera mwayi wokhala ndi lactic acidosis. Zosagwirizana ndi mowa (chiwopsezo chowonjezeka cha mkaka acidosis).

Ntchito yeniyeni, kusefedwa kwa glomerular, ndi shuga wamagazi ziyenera kuyang'aniridwa nthawi zonse. Kuunika mosamala kuchuluka kwa shuga m'magazi ndikofunikira mukamagwiritsa ntchito metformin osakanikirana ndi sulfonylureas kapena insulin (chiopsezo cha hypoglycemia).

Mankhwala osakanikirana ndi metformin ndi insulin amayenera kuchitika kuchipatala kufikira mutapeza mankhwala okwanira. Odwala omwe akupitiliza mankhwala omwe ali ndi metformin, ndikofunikira kudziwa zomwe zili ndi vitamini B12 kamodzi pachaka chifukwa kuchepa kwa mayamwidwe ake.

Ndikofunikira kudziwa mulingo wa lactate mu plasma osachepera 2 pachaka, komanso mawonekedwe a myalgia. Ndi kuchuluka kwa lactate, mankhwalawa amathetsedwa.

Musagwiritse ntchito opaleshoni isanachitike komanso pakatha masiku awiri atachitidwa, komanso ngati mkati mwa masiku awiri asanafike komanso mutatha kuyesa matenda (intravenous urography, angiography, etc.).

Kutulutsa mawonekedwe, kapangidwe kake ndi ma CD

Ma PC 10 - matuza (3) - mapaketi a makatoni 10 ma PC. - matuza (6) - mapaketi a makatoni.

Ma PC 10 - matuza (9) - mapaketi a makatoni.

Zotsatira za pharmacological

Oral hypoglycemic wothandizila kuchokera pagulu la Biguanides (dimethylbiguanide). Kupanga kwa zochita za metformin kumalumikizidwa ndi kuthekera kwake kuponderezera gluconeogeneis, komanso mapangidwe a mafuta achilengedwe omasuka ndi makulidwe a oxidation.

Metformin siyimakhudzanso kuchuluka kwa insulin m'magazi, koma imasintha ma pharmacodynamics pochepetsa kuchuluka kwa insulini kuti imasulidwe ndikuwonjezera kuchuluka kwa insulin kuti proinsulin.

Cholumikizira chofunikira pakupanga metformin ndicho kukoka kwa glucose komwe kumachitika ndi minofu ya minofu.

Metformin imathandizira kufalikira kwa magazi m'chiwindi ndikuthandizira kusintha kwa glucose kukhala glycogen. Lowers triglycerides, LDL, VLDL. Metformin imakweza michere yamagazi ya fibrinolytic mwa kuponderezana ndi minyewa yotulutsa minyewa ya plasminogen activator inhibitor.

Mtundu woyamba wa matenda a shuga 1 mellitus (wodalira insulini) - ndi cholinga chochepetsera kufunikira kwa insulini komanso kupewa kunenepa (kuwonjezera pa insulin Therapy).

Type 2 shuga mellitus (osadalira insulini) pothana ndi vuto losagwirizana ndi zakudya (makamaka kunenepa kwambiri).

Mlingo

Kwa odwala osalandira insulin, masiku atatu - 500 mg katatu kapena tsiku kapena 1 g 2 nthawi / tsiku nthawi yakudya kapena itatha. Kuyambira tsiku la 4 mpaka tsiku la 14 - 1 g katatu kapena tsiku. Pambuyo pa tsiku la 15, mlingo umasinthidwa poganizira kuchuluka kwa shuga m'magazi ndi mkodzo. Mlingo wokonza ndi 100-200 mg / tsiku.

Ndi munthawi yomweyo kugwiritsa ntchito insulin pa mlingo wochepera 40 mayunitsi / tsiku, muyezo wa metformin ndi womwewo, pamene mlingo wa insulin ungachepetse pang'onopang'ono (mwa magawo 4-8 / tsiku tsiku lililonse). Ngati wodwala amalandira zoposa 40 magawo / tsiku, ndiye kuti kugwiritsa ntchito metformin ndi kuchepa kwa insulin kumafunikira chisamaliro chachikulu ndikuchitika kuchipatala.

Analogs ndi mitengo ya mankhwala Langerin

mapiritsi okhala ndi filimu

mapiritsi okhala ndi filimu

mapiritsi okhala ndi filimu

mapiritsi okutira

mapiritsi otulutsidwa

mapiritsi otulutsidwa

mapiritsi okhala ndi filimu

mapiritsi okhala ndi filimu

mapiritsi okhala ndi filimu

mapiritsi okhala ndi filimu

mapiritsi okhala ndi filimu

makanema ojambula okhala ndi mafilimu okhazikika

mapiritsi otulutsidwa

mapiritsi otulutsidwa

mapiritsi okhala ndi filimu

Mavoti onse: madotolo 73.

Zambiri za omwe adayankha mwapadera:

Zotsatira zoyipa

Kuchokera m'mimba: zotheka (nthawi zambiri kumayambiriro kwa chithandizo) mseru, kusanza, kutsekula m'mimba.

Kuchokera ku endocrine system: hypoglycemia (makamaka ikagwiritsidwa ntchito mosayenera).

Kuchokera kumbali ya kagayidwe: Nthawi zina - lactic acidosis (pamafunika kutha kwa mankhwala).

Kuchokera ku hemopoietic system: Nthawi zina - megaloblastic anemia.

Malangizo apadera

Sikulimbikitsidwa kumatenda owopsa, kuchulukitsa kwamatenda opatsirana komanso otupa, kuvulala, matenda opweteka kwambiri, komanso chiopsezo chofuna kuperewera madzi m'thupi.

Osagwiritsa ntchito musanachite opareshoni komanso patatha masiku awiri atachitidwa opereshoni.

Sikulimbikitsidwa kugwiritsa ntchito metformin mwa odwala omwe ali ndi zaka zopitilira 60 ndi omwe akugwira ntchito zolimbitsa thupi, zomwe zimakhudzana ndi chiopsezo chowonjezeka cha lactic acidosis.

Pa mankhwala, m`pofunika kuwunika aimpso, kutsimikiza kwa lactate zili plasma ayenera kuchitika osachepera 2 pachaka, komanso mawonekedwe a myalgia.

Metformin itha kugwiritsidwa ntchito limodzi ndi sulfonylureas. Potere, makamaka kuyang'anira kuchuluka kwa shuga m'magazi ndikofunikira.

Kugwiritsira ntchito metformin monga gawo la mankhwala osakanikirana ndi insulin tikulimbikitsidwa kuchipatala.

Kuyanjana kwa mankhwala

Pogwiritsa ntchito munthawi yomweyo ndimomwe zimachokera ku sulfonylurea, acarbose, insulin, salicylates, ma inhibitors a MAO, oxytetracycline, zoletsa ACE, ndi clofibrate, cyclophosphamide, zotsatira za hypoglycemic za metformin zitha kupititsidwa patsogolo.

Pogwiritsa ntchito munthawi yomweyo ndi GCS, njira yolerera ya mahomoni pakumwa, adrenaline, glucagon, mahomoni a chithokomiro, zotumphukira zochokera kwa thiazide, diuretics, zotumphukira za nicotinic acid, kuchepa kwa mphamvu ya hypoglycemic ya metformin ndikotheka.

Kugwiritsa ntchito cimetidine mozungulira kungakulitse chiopsezo cha lactic acidosis.

37. : 2.92)
Tikutsegula ...

Malangizo LANGERIN (LANAGERIN)

Code ya ATX: A10BA02

Metformin imatengedwa kuchokera m'mimba. Cmax mu plasma imafikira pafupifupi maola awiri atatha kumwa. Pambuyo maola 6, kuyamwa kuchokera m'mimba thirakiti kumatha ndipo kuchuluka kwa metformin m'madzi a m'magazi kumatha kuchepera. Sizingatheke kuti mapuloteni a plasma athere. Imadziunjikira m'magazi amanjenje, chiwindi ndi impso. T1 / 2 - 1.5-5,5 maola.Iwatsitsidwa ndi impso. Ngati vuto laimpso lofooka, metformin imatha kudzikundikira.

Gulani LANGERINE

Gulani pamtengo wotsika:

Alendo athu angakuyamikireni ngati mungalembe komwe mumapeza mankhwala abwino kwambiri pa intaneti.

Miyezo ya alendo pamtengo wa "mtengo / ntchito": 37. : 2.92)
Tikutsegula ...

Ngati mumagwiritsa ntchito mankhwalawa LANZHERIN (LANAGERIN), musakhale aulesi kusiya ndemanga yanu pakugwiritsa ntchito mankhwalawa. Ndikofunika kuyesa LANGERINE ndi magawo awiri: mtengo ndi magwiridwe antchito. Muthandiza ena ngati mungawonetse matenda omwe amayambitsa mankhwalawo.

Langerin - Kufotokozera za mankhwala, malangizo, ntchito, ndemanga

Lembani ndemanga
1 ndemanga

Opanga: Zentiva a.s (Slovak Republic)

Zinthu zogwira ntchito

Gulu la matenda

• Matenda a shuga osagwirizana ndi insulin

Zachipatala ndi gulu la mankhwala

• Zosatchulidwa. Onani malangizo

Zotsatira za pharmacological

Gulu la mankhwala

• Kupanga kwa Hypoglycemic ndi othandizira ena pakuphatikizika

Gwiritsani ntchito pa nthawi yoyembekezera

Pakati pa nthawi yayitali, ndizotheka ngati njira yochiritsira yomwe ikuyembekezeka imapitilira chiwopsezo cha mwana wosabadwayo (maphunziro okwanira komanso okhwima ogwiritsira ntchito panthawi yomwe ali ndi pakati sanachitike).

Gawo la FDA la mwana wakhanda ndi B.

Pa nthawi ya chithandizo ayenera kusiya kuyamwitsa.

Kuchita ndi mankhwala ena

Mphamvu ya metformin imafooketsedwa ndi thiazide ndi ma diuretics ena, corticosteroids, phenothiazines, glucagon, mahomoni a chithokomiro, estrogens, kuphatikizapo monga gawo la njira zakulera zamkamwa, phenytoin, nikotini acid, sympathomimetics, calcium antagonists, isoniazid.

Mlingo umodzi mu odzipereka athanzi, nifedipine kuchuluka kwa mayamwa, Cmax (20%), AUC (9%) metformin, Tmax ndi T1 / 2 sizinasinthe.

Mphamvu ya hypoglycemic imapangidwira ndi insulin, zotumphukira za sulfonylurea, acarbose, NSAIDs, Mao inhibitors, oxytetracycline, zoletsa za ACE, clofibrate zotumphukira, cyclophosphamide, beta-blockers.

Kafukufuku wokhudzana ndi kugwiritsidwa ntchito kwa mlingo umodzi mwa odzipereka athanzi kunawonetsa kuti furosemide imachulukitsa Cmax (ndi 22%) ndi AUC (mwa 15%) ya metformin (popanda kusintha kwakukulu kwachidziwitso cha metformin), metformin imachepetsa Cmax (mwa 31%), AUC (pofika 12) %) ndi T1 / 2 (32%) ya furosemide (popanda kusintha kwakukulu kwa chilolezo cha furosemide). Palibe deta pakukhudzana kwa metformin ndi furosemide ndikugwiritsa ntchito nthawi yayitali. Mankhwala osokoneza bongo (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren ndi vancomycin) omwe amapezeka mu mpikisano wolimbana ndi machitidwe ogwiritsira ntchito ma tubular ndipo, ndi chithandizo chambiri, amatha kuonjezera Cmax ya metformin ndi 60%. Cimetidine amachepetsa kuchotsedwa kwa metformin, yomwe imawonjezera mwayi wokhala ndi lactic acidosis. Zosagwirizana ndi mowa (chiwopsezo chowonjezeka cha mkaka acidosis).

Njira zopewera kugwiritsa ntchito

Ntchito yeniyeni, kusefedwa kwa glomerular, ndi shuga wamagazi ziyenera kuyang'aniridwa nthawi zonse. Kuunika mosamala kuchuluka kwa shuga m'magazi ndikofunikira mukamagwiritsa ntchito metformin osakanikirana ndi sulfonylureas kapena insulin (chiopsezo cha hypoglycemia).

Mankhwala osakanikirana ndi metformin ndi insulin amayenera kuchitika kuchipatala kufikira mutapeza mankhwala okwanira. Odwala omwe akupitiliza mankhwala omwe ali ndi metformin, ndikofunikira kudziwa zomwe zili ndi vitamini B12 kamodzi pachaka chifukwa kuchepa kwa mayamwidwe ake.

Ndikofunikira kudziwa mulingo wa lactate mu plasma osachepera 2 pachaka, komanso mawonekedwe a myalgia. Ndi kuchuluka kwa lactate, mankhwalawa amathetsedwa.

Musagwiritse ntchito opaleshoni isanachitike komanso pakatha masiku awiri atachitidwa, komanso ngati mkati mwa masiku awiri asanafike komanso mutatha kuyesa matenda (intravenous urography, angiography, etc.).

Mankhwala ofanana:

** Chithandizo cha mankhwala Kuti mumve zambiri, chonde onani zomwe akupanga.

Osadzilimbitsa, musanayambe kugwiritsa ntchito Langerin, muyenera kufunsa dokotala. EUROLAB sikuti ali ndi vuto pazotsatira zomwe zimadza chifukwa chogwiritsa ntchito chidziwitso chomwe chatumizidwa pa tsamba.

Zomwe zili patsamba lino sizilowa m'malo mwa upangiri waudokotala ndipo sizingakhale chitsimikizo cha mankhwala.

Kodi mumakonda Langerin? Kodi mukufuna kudziwa zambiri kapena muyenera kukaonana ndi dokotala? Kapena mukufuna kuyesedwa? Mutha kutero pangana ndi adokotala - chipatala Eurolabu nthawi zonse pantchito yanu! Madotolo abwino amayeserera, kukulangizani, kukupatsani chithandizo choyenera ndikupanga matenda. Mukhozanso Itanani dokotala kunyumba. Chipatalachi Eurolabu tsegulani kwa inu nthawi yonse yoyandikira.

** Tcheru! Zomwe zawonetsedwa mu bukhuli zamankhwala ndizothandiza akatswiri azachipatala ndipo siziyenera kukhala chifukwa chodzidziwira nokha. Kufotokozera kwa mankhwala Langerin amaperekedwa kuti awunikenso ndipo sanapangidwe kuti apereke mankhwala popanda kutenga dokotala. Odwala amafunikira upangiri waluso!

Mimba komanso kuyamwa

Contraindified mu mimba ndi mkaka wa m`mawere.

Gwiritsani ntchito ntchito yolakwika ya chiwindi

Amadzipaka chiwindi ntchito kwambiri.

Gwiritsani ntchito ntchito yolakwika yaimpso

Odwala kwambiri aimpso kuwonongeka.

Gwiritsani ntchito mu ukalamba

Metformin sikulimbikitsidwa kwa odwala azaka zopitilira 60, omwe amalumikizidwa ndi chiwopsezo cha lactic acidosis.

Malangizo apadera

Sikulimbikitsidwa kumatenda owopsa, kuchulukitsa kwamatenda opatsirana komanso otupa, kuvulala, matenda opweteka kwambiri, komanso chiopsezo chofuna kuperewera madzi m'thupi.

Osagwiritsa ntchito musanachite opareshoni komanso patatha masiku awiri atachitidwa opereshoni.

Sikulimbikitsidwa kugwiritsa ntchito metformin mwa odwala omwe ali ndi zaka zopitilira 60 ndi omwe akugwira ntchito zolimbitsa thupi, zomwe zimakhudzana ndi chiopsezo chowonjezeka cha lactic acidosis.

Pa mankhwala, m`pofunika kuwunika aimpso, kutsimikiza kwa lactate zili plasma ayenera kuchitika osachepera 2 pachaka, komanso mawonekedwe a myalgia.

Metformin itha kugwiritsidwa ntchito limodzi ndi sulfonylureas. Potere, makamaka kuyang'anira kuchuluka kwa shuga m'magazi ndikofunikira.

Kugwiritsira ntchito metformin monga gawo la mankhwala osakanikirana ndi insulin tikulimbikitsidwa kuchipatala.

Kuyanjana kwa mankhwala

Pogwiritsa ntchito munthawi yomweyo ndimomwe zimachokera ku sulfonylurea, acarbose, insulin, salicylates, ma inhibitors a MAO, oxytetracycline, zoletsa ACE, ndi clofibrate, cyclophosphamide, zotsatira za hypoglycemic za metformin zitha kupititsidwa patsogolo.

Pogwiritsa ntchito munthawi yomweyo ndi GCS, njira yolerera ya mahomoni pakumwa, adrenaline, glucagon, mahomoni a chithokomiro, zotumphukira zochokera kwa thiazide, diuretics, zotumphukira za nicotinic acid, kuchepa kwa mphamvu ya hypoglycemic ya metformin ndikotheka.

Kugwiritsa ntchito cimetidine mozungulira kungakulitse chiopsezo cha lactic acidosis.

37. : 2.92)
Tikutsegula ...

Malangizo LANGERIN (LANAGERIN)

Code ya ATX: A10BA02

Metformin imatengedwa kuchokera m'mimba. Cmax mu plasma imafikira pafupifupi maola awiri atatha kumwa. Pambuyo maola 6, kuyamwa kuchokera m'mimba thirakiti kumatha ndipo kuchuluka kwa metformin m'madzi a m'magazi kumatha kuchepera. Sizingatheke kuti mapuloteni a plasma athere. Imadziunjikira m'magazi amanjenje, chiwindi ndi impso. T1 / 2 - 1.5-5,5 maola.Iwatsitsidwa ndi impso. Ngati vuto laimpso lofooka, metformin imatha kudzikundikira.

Malangizo ogwiritsira ntchito

Kutulutsa mawonekedwe, kapangidwe kake ndi ma CD

Ma PC 10 - matuza (3) - mapaketi a makatoni 10 ma PC. - matuza (6) - mapaketi okhala ndi makatoni. 10 ma PC. - matuza (9) - mapaketi a makatoni.

mapiritsi okhala ndi filimu, 850 mg: 30, 60 kapena 90 ma PC. - LSR-003625/10, 04.30.10

Kwa odwala osalandira insulin, masiku atatu - 500 mg katatu pa tsiku. kapena 1 g 2 pa tsiku. mukamadya kapena mukatha kudya. Kuyambira tsiku la 4 mpaka tsiku la 14 - 1 g katatu pa tsiku. Pambuyo pa tsiku la 15, mlingo umasinthidwa poganizira kuchuluka kwa shuga m'magazi ndi mkodzo. Mlingo wokonza ndi 100-200 mg / tsiku.

Ndi munthawi yomweyo kugwiritsa ntchito insulin mu mankhwala osakwana 40 mayunitsi / tsiku. Mlingo wa metformin ndi womwewo, pamene gawo la insulin limatha kuchepetsedwa pang'onopang'ono (mwa magawo 4-8 / tsiku. tsiku lina lililonse). Ngati wodwala amalandira zoposa 40 magawo / tsiku, ndiye kuti kugwiritsa ntchito metformin ndi kuchepa kwa insulin kumafunikira chisamaliro chachikulu ndikuchitika kuchipatala.

Mimba komanso kuyamwa

Contraindified mu mimba ndi mkaka wa m`mawere.

Gulani LANGERINE

Gulani pamtengo wotsika:

Alendo athu angakuyamikireni ngati mungalembe komwe mumapeza mankhwala abwino kwambiri pa intaneti.

Miyezo ya alendo pamtengo wa "mtengo / ntchito": 37. : 2.92)
Tikutsegula ...

Ngati mumagwiritsa ntchito mankhwalawa LANZHERIN (LANAGERIN), musakhale aulesi kusiya ndemanga yanu pakugwiritsa ntchito mankhwalawa. Ndikofunika kuyesa LANGERINE ndi magawo awiri: mtengo ndi magwiridwe antchito. Muthandiza ena ngati mungawonetse matenda omwe amayambitsa mankhwalawo.

Langerin: ndemanga zamankhwala, mtengo, malangizo

Langerin ndi imodzi mwazamankhwala ambiri omwe amagwiritsidwa ntchito pochiza matenda a matenda a shuga omwe samatengera insulin. Mankhwalawa ndi gawo la gulu la mankhwala a greatuanide, zotsatira zake zazikulu ndikuchepetsa kufunikira kwa kupanga insulini.

Mtengo wa Langerin m'masitolo ogulitsa, kutengera mlingo womwe ungafunike, ukhoza kuchokera ku ruble zana limodzi mpaka mazana atatu.

Langerin ndi mankhwala apiritsi a pakamwa omwe amagwiritsidwa ntchito pochiritsira matenda a shuga. Gawo lake lalikulu ndi mankhwala a metformin. Mankhwalawa ndi amodzi mwa mankhwala ochepetsa shuga ndipo nthawi zambiri amagwiritsidwa ntchito kuti matenda ashuga azikhala ndi matenda ashuga.

Chimodzi mwazomwe mungafotokozere za mankhwalawa ndi kukhazikitsidwa kwake ngati mapiritsi omwe amagwiritsidwa ntchito kale kuchokera ku gulu la sulfonylurea. Kuphatikiza apo, kunenepa kwambiri ndi vuto lolumikizana kwa anthu onse omwe ali ndi matenda ashuga.

Chifukwa chake, Langerin samangoleketsa kuchuluka kwa shuga, komanso zimathandizira kuti wodwalayo achulukane.

Katundu wama mankhwala ndi zizindikiro zogwiritsira ntchito

Kupanga kwa gawo lalikulu la mankhwala kumalumikizidwa ndi mphamvu yake yoletsa njira za gluconeogeneis, komanso njira za kaphatikizidwe wamafuta acids amafuta ndi oxidation wamafuta.

Woimira kalasi la Biguanide samakhudza kuchuluka kwa insulin yomwe imatulutsidwa m'magazi, koma amasintha ma pharmacodynamics awo mwa kuchepetsa kuchuluka kwa insulini kumasulidwa ndikuwonjezera kuchuluka kwa insulini kuti proinsulin.

Chofunikira pakuwoneka kwa mapiritsi oterewa ndi kukondoweza kwa glucose omwe amapezeka m'maselo a minofu.

Chizindikiro chachikulu chogwiritsira ntchito mankhwalawa ndikutukuka kwa matenda a shuga omwe amadalira insulin mwa munthu, makamaka ndi kusakwanira kwa zakudya zomwe amatsata.

Mankhwala enieni a Langerin ndi awa:

• amachepetsa kuchuluka kwa hemoglobinꓼ ya glycated
• saiziwalitsa kukana kwa insulini m'maselo kupita ku ma insulin a insulin
• zimakhudza kutengera kwa mawonekedwe a lipid a plasmaꓼ
• amachepetsa cholesterolꓼ yoyipa

Kuphatikiza apo, kugwiritsa ntchito mankhwalawa kumatha kulimbitsa thupi.

Malangizo ogwiritsira ntchito mapiritsi

Mankhwala Langerin amapezeka mu mawonekedwe a mapiritsi okhala ndi tulo.

Mapiritsiwo amadzaza ndi thumba la pulasitiki, lomwe limasindikizidwa ndi zojambulazo za aluminiyamu.

Mapaketi amaikidwa pabokosi la makatoni pamodzi ndi malangizo ogwiritsira ntchito mankhwalawa.

Kutengera kuchuluka kwa mankhwalawa omwe agwiritsidwa ntchito, mankhwalawa atha kugulidwa ndi mlingo wa:

1. Ma milligram 500.
2. Ma milligram 850.
3. Gramu imodzi yogwira ntchito.

Njira yothetsera mapiritsiwa imakhala pakumwa, panthawi yakudya kapena itatha. Dotoloyo akupereka mankhwala kwa wodwala aliyense payekha malinga ndi kuopsa kwa matendawa. Komanso, katswiri wazachipatala amazindikira kuchuluka kwa mankhwalawa tsiku lililonse masana.

Langerin-malangizo angagwiritsidwe ntchito amalimbikitsa kuyambitsa njira yochiritsira yolimbitsa thupi ndi osachepera 500 mg a yogwira ntchito. Kuchuluka kwa Mlingo wa mankhwalawa masana kungakhale kwa mmodzi kapena atatu.

Pang'onopang'ono, mlingo ungathe kuwonjezeka mpaka 850 mg wa chinthu chogwira tsiku lonse (kamodzi kawiri pa tsiku).

Dokotala wothandizirayo amawunikira wodwalayo ndipo osapitirira kamodzi pa sabata, amasintha mlingo wa mankhwalawo.

Mankhwalawa adapangidwanso zochizira matendawa ana opitirira zaka khumi. Monotherapy iyenera kuyamba ndi mlingo wa 500 mg yogwira ntchito kamodzi kapena kawiri pa tsiku. Pakapita kanthawi, kuwonjezeka kwapang'onopang'ono kwa mlingo wa mankhwalawa amaloledwa, koma osaposa magalamu awiri patsiku, omwe amagawidwa pawiri kapena katatu.

Nthawi zambiri, kusintha kwa muyezo wa mankhwalawa kumachitika pakatha masiku khumi mpaka khumi ndi asanu potengera zotsatira za kuyezetsa magazi pamlingo wama glucose.

Nthawi zina, kuphika piritsi ndi gawo limodzi la mankhwala ophatikiza ndi jakisoni wa insulin.

Tiyenera kudziwa kuti munthawi yomweyo mankhwala a Langerin omwe ali ndi insulin, zotumphukira za sulfonylurea, acarbose, kapena ACE inhibitors amadziwika kuti amawonjezera mphamvu ya hypoglycemic ya mankhwala.

Nthawi zina, dokotala yemwe amapezekapo akhoza kusintha kugwiritsa ntchito Langerin ndi mapiritsi ofanana. Masiku ano, pali mitundu yambiri ya mankhwala, omwe amagwiritsidwa ntchito kwambiri ndi metformin.

Mtengo wa mankhwala a analog ukhoza kusiyana kwambiri, kutengera kampani yopanga mankhwala.

Kodi zotsutsana ndizogwiritsa ntchito chiyani?

Mlingo wosankhidwa molakwika kapena kusatsatira malangizo a dokotala kungakupangitseni kuoneka ngati musanamwe mankhwala.

Kuphatikiza apo, pali zochitika zina komwe kugwiritsa ntchito mankhwala ozungulira metformin ndikoletsedwa.

Malangizo ogwiritsira ntchito mankhwalawa akuwonetsa mndandanda wazotsatira zazikulu.

Milandu yayikulu pakugwiritsa ntchito mapiritsi a Langerin ndi awa:

• kuwonongeka kwakukulu kwa chiwindi kapena impso, kusakwanira kwawo
• uchidakwa, kuphatikiza pamakhalidwe oyipaꓼ
• mtima kapena kupuma
• pachimake myocardial infarctionꓼ
• mkhalidwe wodwala matenda ashuga kapena kholo
• chitukuko cha matenda ashuga phaziꓼ
• pamaso pa tsankho la munthu ndi metformin komanso kusintha kwa zinthu zina zosagwirizana ndi gawoꓼ
• kukhalapo kwa matenda opatsirana infectious
• kusala ndi matenda ashuga kapena kutsatira zakudya zomwe zakudya zake za tsiku ndi tsiku siziposa kilocaloriesꓼ
• Opaleshoni isanachitike komanso itachitika
• ndimavulala azambiri recent
• isanachitike komanso itatha diagnostic omwe amagwiritsa ntchito radio isotropes ya iodineꓼ
• ketoacidosis ndi lactic acidosis.

Kuphatikiza apo, azimayi sayenera kumwa mankhwalawa panthawi yoyembekezera komanso mkaka wa m'mawere.

Kupezeka kwa zoyipa kumatha kudziwonekera mwa mbali zosiyanasiyana za thupi ndi machitidwe a thupi - m'mimba thirakiti, kagayidwe kazinthu, mtima dongosolo, khungu. Zoyipa zazikulu zomwe zimachitika chifukwa ch kumwa mankhwalawa ndi:

1. Kukweza mwachangu. Nthawi zina mseru umapezeka mu mtundu 2 shuga. Khansa ya m'mimba ikhoza kulowa m'malo mwa kusanza.
2. Mtundu wopweteka wam'mimba.
3. Maonekedwe akununkhira wachitsulo pamkamwa wamkamwa.
4. Hematopoiesis ndi heestasis.
5. Megaloblastic anemia.
6. Kutsitsa shuga m'magazi pansi pazovomerezeka - hypoglycemia.
7. Maonekedwe ofooka m'thupi.
8. Kugona.
9. Hypotension.
10. Matenda opatsirana.
11. Maonekedwe a dermatitis kapena totupa pakhungu.

Chenjezo liyenera kumwedwa mukamamwa Langerin ndi mankhwala ena. Kugwiritsa ntchito pamodzi mapiritsi ndi cymeditine kumawonjezera chiopsezo cha lactic acidosis. Kuphatikiza kwa Langerin ndi ma loopture otentha kumatha kukhala ndi zotsatira zomwezo. Pankhaniyi, kuwonjezera pakuwonetsedwa kwa lactic acidosis, chiwonetsero cha kulephera kwa impso chitha kuonedwa.

Kugwiritsa ntchito mankhwalawa, ndikofunikira kuyang'anira momwe impso zimagwirira ntchito ndikuwonetsa kuchuluka kwa lactate mu plasma osachepera kawiri pachaka.

Zambiri zokhudzana ndi mankhwala omwe amagwiritsidwa ntchito pochiza matenda a shuga zimaperekedwa mu kanema munkhaniyi.

Sonyezani shuga yanu kapena sankhani jenda kuti muyimikize.

Langerin - Kufotokozera za mankhwala, malangizo, ntchito, ndemanga

Lembani ndemanga
1 ndemanga

Opanga: Zentiva a.s (Slovak Republic)

Zinthu zogwira ntchito

Gulu la matenda

• Matenda a shuga osagwirizana ndi insulin

Zachipatala ndi gulu la mankhwala

• Zosatchulidwa. Onani malangizo

Zotsatira za pharmacological

Gulu la mankhwala

• Kupanga kwa Hypoglycemic ndi othandizira ena pakuphatikizika

Mapiritsi a pakamwa Langerin (Lanagerin)

Malangizo ogwiritsira ntchito mankhwalawa

Zizindikiro zogwiritsidwa ntchito

Type 2 shuga mellitus (makamaka pamavuto a kunenepa kwambiri) ndi kulephera kwa kukonza kwa matenda a hyperglycemia kuphatikiza ndi sulfonylurea kukonzekera.

Kutulutsa Fomu

Mapiritsi 500 okhala ndi mafilimu, blister pack 10 pack of boardboard 6 pack, 500 mg-film-coated mapiritsi, blister pack 10 pack 10 of boardboard 3, 500 mg film-coated mapiritsi, blister pack 10 pack of Cardboard 9, mapiritsi, 850 mg film-yokutira, blister pack 10 pack ya makatoni 6, mapiritsi, 850 mg film-yokutira paketi, 850 mg film blister pack, 10 paketi yamakatoni 3, mapiritsi okhala ndi filimu 850 mg, blister paketi 10 paketi yamakatoni 9, mapiritsi okhala ndi kanema wovindikira 1 g, blister pack 10 pack of boardboard 1, mapiritsi okhala ndi filimu yopanda 1 g, blister packing 10 pack ofboardboard 3, mapiritsi okhala ndi filimu ya ganda 1 g, blister pack 10 Phukusi la makatoni 9,

mapiritsi okutidwa ndi filimu yophimba 1 g, matuza akuyika ma pack 10 makatoni 6,

Gwiritsani ntchito pa nthawi yoyembekezera

Pakati pa nthawi yayitali, ndizotheka ngati njira yochiritsira yomwe ikuyembekezeka imapitilira chiwopsezo cha mwana wosabadwayo (maphunziro okwanira komanso okhwima ogwiritsira ntchito panthawi yomwe ali ndi pakati sanachitike).

Gawo la FDA la mwana wakhanda ndi B.

Pa nthawi ya chithandizo ayenera kusiya kuyamwitsa.

Kuchita ndi mankhwala ena

Mphamvu ya metformin imafooketsedwa ndi thiazide ndi ma diuretics ena, corticosteroids, phenothiazines, glucagon, mahomoni a chithokomiro, estrogens, kuphatikizapo monga gawo la njira zakulera zamkamwa, phenytoin, nikotini acid, sympathomimetics, calcium antagonists, isoniazid.

Mlingo umodzi mu odzipereka athanzi, nifedipine kuchuluka kwa mayamwa, Cmax (20%), AUC (9%) metformin, Tmax ndi T1 / 2 sizinasinthe.

Mphamvu ya hypoglycemic imapangidwira ndi insulin, zotumphukira za sulfonylurea, acarbose, NSAIDs, Mao inhibitors, oxytetracycline, zoletsa za ACE, clofibrate zotumphukira, cyclophosphamide, beta-blockers.

Kafukufuku wokhudzana ndi kugwiritsidwa ntchito kwa mlingo umodzi mwa odzipereka athanzi kunawonetsa kuti furosemide imachulukitsa Cmax (ndi 22%) ndi AUC (mwa 15%) ya metformin (popanda kusintha kwakukulu kwachidziwitso cha metformin), metformin imachepetsa Cmax (mwa 31%), AUC (pofika 12) %) ndi T1 / 2 (32%) ya furosemide (popanda kusintha kwakukulu kwa chilolezo cha furosemide). Palibe deta pakukhudzana kwa metformin ndi furosemide ndikugwiritsa ntchito nthawi yayitali. Mankhwala osokoneza bongo (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren ndi vancomycin) omwe amapezeka mu mpikisano wolimbana ndi machitidwe ogwiritsira ntchito ma tubular ndipo, ndi chithandizo chambiri, amatha kuonjezera Cmax ya metformin ndi 60%. Cimetidine amachepetsa kuchotsedwa kwa metformin, yomwe imawonjezera mwayi wokhala ndi lactic acidosis. Zosagwirizana ndi mowa (chiwopsezo chowonjezeka cha mkaka acidosis).

Njira zopewera kugwiritsa ntchito

Ntchito yeniyeni, kusefedwa kwa glomerular, ndi shuga wamagazi ziyenera kuyang'aniridwa nthawi zonse. Kuunika mosamala kuchuluka kwa shuga m'magazi ndikofunikira mukamagwiritsa ntchito metformin osakanikirana ndi sulfonylureas kapena insulin (chiopsezo cha hypoglycemia).

Mankhwala osakanikirana ndi metformin ndi insulin amayenera kuchitika kuchipatala kufikira mutapeza mankhwala okwanira.Odwala omwe akupitiliza mankhwala omwe ali ndi metformin, ndikofunikira kudziwa zomwe zili ndi vitamini B12 kamodzi pachaka chifukwa kuchepa kwa mayamwidwe ake.

Ndikofunikira kudziwa mulingo wa lactate mu plasma osachepera 2 pachaka, komanso mawonekedwe a myalgia. Ndi kuchuluka kwa lactate, mankhwalawa amathetsedwa.

Musagwiritse ntchito opaleshoni isanachitike komanso pakatha masiku awiri atachitidwa, komanso ngati mkati mwa masiku awiri asanafike komanso mutatha kuyesa matenda (intravenous urography, angiography, etc.).

Kukhala gulu la ATX:

Matumbo a kagayidwe komanso kagayidwe

A10 Mankhwala osokoneza bongo

Mankhwala a A10B Oral hypoglycemic

Mankhwala ofanana:

** Chithandizo cha mankhwala Kuti mumve zambiri, chonde onani zomwe akupanga.

Osadzilimbitsa, musanayambe kugwiritsa ntchito Langerin, muyenera kufunsa dokotala. EUROLAB sikuti ali ndi vuto pazotsatira zomwe zimadza chifukwa chogwiritsa ntchito chidziwitso chomwe chatumizidwa pa tsamba.

Zomwe zili patsamba lino sizilowa m'malo mwa upangiri waudokotala ndipo sizingakhale chitsimikizo cha mankhwala.

Kodi mumakonda Langerin? Kodi mukufuna kudziwa zambiri kapena muyenera kukaonana ndi dokotala? Kapena mukufuna kuyesedwa? Mutha kutero pangana ndi adokotala - chipatala Eurolabu nthawi zonse pantchito yanu! Madotolo abwino amayeserera, kukulangizani, kukupatsani chithandizo choyenera ndikupanga matenda. Mukhozanso Itanani dokotala kunyumba. Chipatalachi Eurolabu tsegulani kwa inu nthawi yonse yoyandikira.

** Tcheru! Zomwe zawonetsedwa mu bukhuli zamankhwala ndizothandiza akatswiri azachipatala ndipo siziyenera kukhala chifukwa chodzidziwira nokha. Kufotokozera kwa mankhwala Langerin amaperekedwa kuti awunikenso ndipo sanapangidwe kuti apereke mankhwala popanda kutenga dokotala. Odwala amafunikira upangiri waluso!

Zogwira ntchito

- metformin hydrochloride (metformin)

Mimba komanso kuyamwa

Maphunziro okwanira komanso osamalitsa okhazikika otetezeka a metformin pa nthawi yomwe ali ndi pakati sanachitike. Kugwiritsa ntchito pa nthawi ya pakati ndikotheka pazochitika zadzidzidzi, pomwe phindu la chithandizo cha mayiyo limaposa chiwopsezo cha mwana wosabadwayo. Metformin iwoloka chotchinga.

Metformin yaying'ono imachotsedwa mkaka wa m'mawere, pomwe kuchuluka kwa metformin mkaka wa m'mawere kumatha kukhala 1/3 ya kuchuluka kwa plasma ya amayi. Zotsatira zoyipa za akhanda pa nthawi yoyamwitsa pamene mukumwa metformin sizinawoneke.

Komabe, chifukwa cha kuchuluka kwa deta, kugwiritsa ntchito nthawi yoyamwitsa sikulimbikitsidwa.

Lingaliro loletsa kuyamwitsa liyenera kuchitika poganizira zabwino za kuyamwitsa ndi chiopsezo cha zovuta zoyambira mwana.

Kafukufuku wam'mbuyomu wasonyeza kuti metformin ilibe mphamvu poyerekeza Mlingo womwe umakhala wotalika katatu kuposa mankhwala omwe amagwiritsidwa ntchito mwa anthu. Metformin ilibe mutagenic angathe, sichikhudza chonde.