Liraglutide zochizira kunenepa kwambiri ndi matenda a shuga

* Mwa kudina batani "Tumizani", ndimapereka chilolezo changa pakukonzanso kwandalama zanga malinga ndi mfundo zachinsinsi.

Liraglutide, yomwe yayamba kufalitsa ku United States pansi pa dzina la Victoza, si njira yatsopano yatsopano - yakhala ikugwiritsidwa ntchito kuyambira 2009 pochiza matenda a shuga a mtundu wachiwiri. Wothandizirawu wa hypoglycemic ndi jakisoni ndipo wavomerezedwa kuti azigwiritsidwa ntchito ku United States, Russia ndi mayiko ena mu mawonekedwe a Viktoza kuchokera ku wopanga Danish Novo Nordisk. Kuyambira 2015, Liraglutide imapezekanso pansi pa dzina la malonda Saksenda ndipo imayikidwa ngati mankhwala ochizira kunenepa kwambiri kwa akuluakulu.

Mwachidule, zinthu zomwezi zogwiritsidwa ntchito m'magulu osiyanasiyana ogulitsa zimagwiritsidwa ntchito pochiza matenda a shuga komanso pochotsa kunenepa kwambiri kwa thupi.

Zimagwira bwanji?

Liraglutide ndi kapangidwe kake kamene kamakhala ngati glucagon-peptide-1 (GLP-1), kamene kali 97% kofanana ndi mtundu wawo. Zotsatira zake, thupi silisiyanitsa pakati pa ma enzymes enieni opangidwa ndi thupi ndikulowetsedwa. Liraglutide mwanjira ya glucagon-ngati peptide-1 imamangirira kuzinthu zomwe zimafunidwa ndikuwonjezera kupanga kwa insulin, glucagon. Popita nthawi, njira zachilengedwe zopangira insulin zikukhazikitsidwa, zomwe zimatsogolera ku standardoglycemia.

Kamodzi m'magazi kudzera mu jakisoni, mankhwalawa amakulitsa kuchuluka kwa peptides mthupi. Zotsatira zake, ntchito ya pancreatic imabwezeretsedwa, kuchuluka kwa shuga kwa wodwalayo kumachepetsedwa kukhala malire oyenera. Izi, zimathandizira kuti pakhale chidwi chokwanira cha zinthu zopindulitsa kuchokera ku chakudya, zomwe zimakupatsani mwayi kuti muchotse mawonekedwe osiyanasiyana a matenda ashuga.

Amagwiritsidwa ntchito bwanji pochiza kunenepa

Kuti muchepetse kunenepa kwambiri kwa thupi, ndikofunikira kugwiritsa ntchito Liraglutid pakuchepetsa thupi, mu fomu ya "Saksenda". Wogulitsidwa mu mawonekedwe a cholembera, womwe umathandizira kuyambitsa kwake. Pali magawano pa syringe kuti adziwe kuchuluka kwa mankhwalawa. Kuphatikizika kwa mitundu ya kumwa kuchokera pa 0,6 mpaka 3 mg mukukula kwa 0,6 mg.

Malangizo ogwiritsira ntchito mawonekedwe a Saxenda

Mlingo wovomerezeka tsiku lililonse wa Saxenda ndi 3 mg. Pankhaniyi, palibe kudalira nthawi ya tsiku, kudya zakudya ndi mankhwala ena. Mu sabata yoyamba, mlingo ndi 0.6 mg, sabata iliyonse yotsatira kuchuluka kwa zinthu zomwe zimagwira ntchito zimawonjezeka ndi 0,6 mg. Kuyambira sabata 5, mpaka kumapeto kwa maphunzirowo, wodwalayo satenga zoposa 3 mg tsiku lililonse.

Mankhwalawa amaperekedwa kamodzi pachaka pa ntchafu, phewa kapena pamimba. Nthawi yoyang'anira ikhoza kusinthidwa, yomwe siyiyenera kukhudza mlingo wa mankhwalawa.

Tengani Liraglutide kuti muchepetse kunenepa tikulangizidwa ndi adokotala. Monga lamulo, mankhwalawa amalembedwa kwa odwala omwe ali ndi matenda a shuga a 2 omwe sangathe kulemetsa awo okha ndikulipira mapaundi owonjezera. Komanso, mankhwalawa amagwiritsidwa ntchito kubwezeretsa index ya glycemic mwa odwala omwe chizindikiro ichi chimakhala choperewera.

Malangizo ogwiritsira ntchito mankhwalawa

Liraglutide pochiza matenda a shuga a mtundu wachiwiri ndi kunenepa kwambiri ayenera kugwiritsidwa ntchito mu mtundu wa Saksenda, mutha kugula ngati cholembera. Magawikawa amakonzera syringe, amathandizira kudziwa kuchuluka kwa mankhwalawo ndikuwongolera kayendetsedwe kake. Masewera omwe amagwiritsidwa ntchito amachokera ku 0,6 mpaka 3 mg, gawo ndi 0,6 mg.

Tsiku la wamkulu wokhala ndi kunenepa kwambiri motsutsana ndi matenda a shuga limafuna 3 mg ya mankhwalawa, pomwe nthawi ya tsiku, kudya zakudya ndi mankhwala ena sikuchita mbali yapadera. Mu sabata yoyamba yamankhwala, tsiku lililonse ndikofunikira jekeseni ya 0,6 mg, sabata iliyonse yotsatira mugwiritse ntchito kuchuluka kwa 0,6 mg. Kale sabata lachisanu la chithandizo ndipo kumapeto kwa maphunzirowa, ndikulimbikitsidwa kuti mupeze jakisoni wambiri kuposa 3 mg patsiku.

Mankhwalawa amayenera kuperekedwa kamodzi patsiku, chifukwa ichi mapewa, m'mimba kapena ntchafu ndizoyenera. Wodwalayo amatha kusintha nthawi ya makonzedwe a mankhwala, koma izi siziyenera kuwonetsedwa mu mlingo. Kuchepetsa thupi, mankhwalawa amagwiritsidwa ntchito kokha chifukwa cha endocrinologist.

Nthawi zambiri, mankhwala a Viktoza ndiofunika kwa omwe ali ndi matenda ashuga a 2 omwe sangachepetse thupi ndikusintha momwe alili poyerekeza ndi maziko a:

1. zakudya mankhwala
2. kumwa mankhwala ochepetsa shuga.

Ndikofunikanso kugwiritsa ntchito mankhwalawa kubwezeretsa glycemia kwa odwala omwe akuvutika ndi kusintha kwa glucose.

Contraindication

• kusalolera payekhapayekha,
• mtundu 1 shuga
• matenda akulu a impso ndi chiwindi,
• kulephera kwamtima kwamitundu 3 ndi 4,
• matenda amatupa,
• zotupa za chithokomiro,
• angapo endocrine neoplasia syndrome,
• mimba ndi mkaka wa m`mawere.

Zopanda phwando:

• nthawi yomweyo ngati insulin
• ndi agonist wina aliyense wa GLP-1 receptor,
• anthu opitilira zaka 75
• odwala omwe ali ndi pancreatitis (momwe thupi silinaphunzirire).

Mosamala, mankhwalawa amaperekedwa kwa anthu omwe amadziwika ndi mtima. Sizikudziwikanso bwino momwe mankhwalawa amathandizira akamamwa ndi mankhwala ena ochepetsa thupi. Pankhaniyi, sikoyenera kuyesa komanso kuyesa mitundu yosiyanasiyana ya mankhwala yochepetsera kunenepa. Ndiosafunika kuti ana komanso achinyamata azaka zosaposa 18 azigwiritsa ntchito mankhwalawa - kulangizidwa koteroko kumatsimikiziridwa ndi adokotala atamupima ndikuwunika.

Zotsatira zoyipa

Chowonekera kwambiri cha atypical cha mankhwalawa ndikuphwanya kwam'mimba thirakiti. Mu 40% ya milandu, nseru imapezeka. Mwa awa, pafupifupi theka amakhalanso akusanza. Wodwala wachisanu aliyense, akamamwa mankhwalawa, amadandaula za matenda am'mimba, ndi gawo lina - kudzimbidwa. Pafupifupi 7-8% ya anthu omwe amamwa mankhwalawa kuti achepetse thupi amadandaula za kutopa kwambiri. Makamaka ochenjera ayenera kukhala odwala omwe ali ndi mtundu wa matenda a shuga 2 - wodwala aliyense wachitatu atatha kuperewera kwa liraglutide, hypoglycemia wapezeka.

Zotsatira zotsatirazi zathupi kutengera mtundu wina wa liraglutide ndizothekanso:

• mutu
• chapamwamba kupuma thirakiti matenda
• chisangalalo
• kuchuluka kwa mtima,
• ziwengo

Zotsatira zonse zoyipa zimadziwika sabata loyamba kapena lachiwiri la kumwa mankhwalawa kutengera liraglutide. Pambuyo pake, kufalikira kwamphamvu ndi kuzimba kwa ziwalo zoterezi kumatsika ndipo pang'onopang'ono zimasowa. Popeza liraglutide imayambitsa zovuta kutulutsa m'mimba, izi zimakhudza kuchuluka kwa mayamwa ena. Komabe, zosinthazi ndizochepa, chifukwa chake, kusintha kwa mankhwalawa sikofunikira. Mutha kugwiritsa ntchito mankhwalawa nthawi imodzi ndi othandizira okhala ndi metformin kapena mankhwala osokoneza bongo pamodzi ndi metformin ndi thiazolidinedione.

Kugwiritsa Ntchito Kuchepetsa Thupi

Mankhwala ozikidwa pa yogwira mankhwala liraglutide, amathandizira kuwonda makamaka chifukwa amalepheretsa kuchuluka kwa chakudya m'mimba. Zotsatira zake, chidwi cha munthu chimachepa, ndipo amadya pafupifupi 15-20% kuposa kale.

Kugwiritsa ntchito bwino kwa mankhwalawo kumakhala kokwanira kwambiri ngati mungagwiritse ntchito ngati zowonjezera ku zakudya zochepa zama calorie. Chida ichi sichingagwiritsidwe ntchito ngati njira yokhayo yochepetsera kunenepa. Sizotheka kuchotsa "ballast" mothandizidwa ndi jakisoni nokha. Ndikulimbikitsidwanso kuti musiye zizolowezi zoyipa ndikulimbitsa thupi. Pansi pa izi, zotsatira za kuchepa thupi mutamaliza maphunzirowa ndi 5% mwa theka la iwo omwe amamwa mankhwalawo ndi 10% mwa theka la odwala omwe ali ndi matenda ashuga. Pafupifupi, odwala oposa 80% amafotokoza zabwino zochepetsa thupi atayamba kugwiritsa ntchito mankhwalawa. Zotsatira zoterezi zitha kuyembekezedwa pokhapokha mulingo wambiri wa mankhwala sunali wochepera 3 mg.

Mtengo wa liraglutide umatsimikiziridwa ndi kuchuluka kwa yogwira ntchito.

1. "Victoza" yankho la subcutaneous makonzedwe a 6 mg / ml, 3 ml, N2 (Novo Nordisk, Denmark) - kuchokera 10,000 rubles.
2. "Victoza" makatoni ndi syringe cholembera 6 mg / ml, 3 ml, 2 ma PC. (Novo Nordisk, Denmark) - kuchokera ku ruble 9,5,000.
3. Victoza, 18 mg / 3 ml cholembera syringe, 2 ma PC. (Novo Nordisk, Denmark) - kuchokera ku ruble 9,000.
4. "Saksenda" yankho la subcutaneous makonzedwe a 6 mg / ml, cartridge mu syringe cholembera 3 ml, 5 ma PC. (Novo Nordisk, Denmark) - ma ruble 27,000.

Liraglutide mu mawonekedwe a "Victoza" ndi "Saxenda" ali ndi mitundu ingapo yofanana ndi yofanana mthupi komanso pochizira:

1. Novonorm (mapiritsi, kuchokera ku ma ruble 140 mpaka 250) amagwiritsidwa ntchito pochiza matenda a shuga a 2, pang'onopang'ono kutsika magazi.
2. "Baeta" (syringe cholembera, pafupifupi ma ruble 10,000) - amatanthauza amino acid amidopeptides. Imalepheretsa kuphwanya kwa m'mimba, kumachepetsa chilimbikitso.
3. "Lixumia" (cholembera cha syringe, kuyambira ma ruble 2.5-7 chikwi) - amachepetsa kuchuluka kwa shuga m'magazi, mosasamala kanthu za chakudya.
4. "Forsiga" (mapiritsi, ochokera ku ma ruble 1.8-2.8) - amalepheretsa kuyamwa kwa glucose, kuchepetsa kuyamwa kwake atatha kudya.

Kuvomerezeka kwa kugwiritsa ntchito ma analogu m'malo mwa Liraglutide kuti muchepetse kunenepa, adokotala omwe amapita ndi omwe amawona. Zisankho zodziyimira pankhaniyi ndizosayenera, chifukwa zimatha kudzetsa mayankho ambiri komanso kutsika kwa njira yothandizira.

Ndemanga ndi zotsatira za kuchepa thupi

Valentina, wazaka 49

Patatha mwezi umodzi ndikumamwa liraglutide, shuga anali osungika pa 5.9 mmol / l, ngakhale sanatsala pang'ono kutsika ndi 10 komanso mpaka 12. Inde, ndinaphatikiza mankhwalawo ndi zakudya, kusiya zakudya zanga zomwe ndimakonda koma zovulaza. Koma ndayiwala za kupweteka kwa kapamba komanso kuchepa thupi, nditataya kale 3 kg!

Mwana wanga wachiwiri atabadwa, thanzi langa linagwedezeka kwambiri. Ndidachira 20 kg, ndipo kuwonjezera apo ndidadwala matenda ashuga 2. Adotolo adalangiza mankhwala a Saksenda. Inde, sizotsika mtengo konse ayi, koma zimawononga ndalama zake. Choyamba, jakisoni itatha, mutu wanga umatuluka, ndipo anali kudwala kwambiri, tsopano thupi limagwiritsidwanso ntchito. Kwa miyezi 1.5 yakuvomerezedwa, ndinataya 5 kg, ndipo thanzi langa linayenda bwino. Tsopano kusamalira ana sikovuta.

Ndemanga za madotolo ndi akatswiri

Leonova Tatyana, Yaroslavl. Endocrinologist

Ndimapereka mankhwala a Liraglutide pafupipafupi, popeza cholinga chachikulu pakuthandizira matenda ashuga ndikwaniritsa kuchepa kwa shuga m'magazi osakhala ndi zotsatirapo zochepa mthupi. Cholinga ichi ndichotheka ndi mankhwala omwewo, koma okwera mtengo. Pazonse, ndikuwona kuti Liraglutid amathandizadi ndi ntchitozo, pokhapokha ngati wodwala amakwaniritsa zonse zomwe amalimbikitsa - amasintha zakudya, akuchita zolimbitsa thupi. Poterepa, kuwonjezera pa kuchepetsa shuga, kuchepa thupi kwa pafupifupi kilogalamu 5-7 kumawonedwa kwa miyezi iwiri.

Dudaev Ruslan, Woopsa. Endocrinologist

Ngati wodwala ali ndi mwayi wolipira mankhwalawa ndi Lyraglutide, ndikupangira iye mankhwalawa. Anawonetsa kuyesetsa kwake osati pothandizira matenda ashuga amtundu wa 2, komanso pochotsa kunenepa kwambiri. Komabe, ndikulimbikira kuperekera malangizo molondola kwambiri kuti muchepetse kuyambitsa mavuto. Kuphatikiza apo, kuchepa thupi, kugwiritsa ntchito mankhwalawa kwa nthawi yayitali kumalimbikitsidwa chifukwa chokhazikika komanso chokhazikika.

Momwe mungalimbane ndi kunenepa kwambiri

Pali nkhani zambiri zonena za kunenepa kwambiri, masemina ndi misonkhano yamisonkhano imachitika pamlingo wapadziko lonse wokhudza matenda ashuga, endocrinology, mankhwala ambiri, zowona ndi maphunziro zimaperekedwa chifukwa cha matendawa, ndikuti kwa munthu aliyense, kukhala wonenepa kwambiri nthawi zonse kumakhala vuto lokongoletsa. Kuti muthandizire odwala anu kuchepetsa thupi ndikukhala ndi zotsatira zabwino, ndikofunikira kufunsa katswiri wazokhudza endocrinology ndi zakudya.

Kukumbukira zonse zomwe zili pamwambapa, choyambirira, ndikofunikira kudziwa bwino mbiri yamatendawa. Chofunikira kwambiri pothandizira kunenepa kwambiri ndikukhazikitsa cholinga choyambirira - chomwe chimafuna kuchepetsa thupi. Pokhapokha pokhapokha ngati chithandizo chofunikira chitha kufotokozedwa bwino. Ndiye kuti, atafotokoza zolinga zomveka kuti athe kuchepetsa thupi, dokotala amamulembera pulogalamu yam'tsogolo ndi wodwala.

Kunenepa kwambiri

Chimodzi mwazomwe amamwa mankhwalawa ndi chida cha Liraglutide (Liraglutide). Sichatsopano, idayamba kugwiritsidwa ntchito mu 2009. Ndi chida chomwe chimachepetsa shuga mumagazi a seramu ndipo amalowetsedwa m'thupi.

Kwenikweni, amalembera mtundu wachiwiri wa matenda ashuga kapena kuthandizira kunenepa kwambiri, kuti aletse kuphatikizira kwa chakudya (glucose) m'mimba. Pakadali pano, kupanga mankhwala okhala ndi dzina lina lodziwika "Saxenda" (Saxenda) kwayamba kukhazikitsidwa pamsika wamtunduwu amadziwika ndi dzina lodziwika bwino lotchedwa "Viktoza". Zomwezi zomwe zimakhala ndi mayina osiyanasiyana ogulitsa zimagwiritsidwa ntchito pochiza odwala omwe ali ndi mbiri ya matenda ashuga.

Liraglutide anafuna zochizira kunenepa. Kunenepa kwambiri, wina anganene, "kuneneratu" kwa matenda ashuga wazaka zilizonse. Chifukwa chake, polimbana ndi kunenepa kwambiri, timapewa kuyambika ndi kukula kwa matenda ashuga.

Mfundo yogwira ntchito

Mankhwalawa ndi chinthu chopezeka mosiyanasiyana, chofanana ndi peptide ya glucagon. Mankhwalawa ali ndi mphamvu yayitali, ndipo kufanana kwake ndi 97% ndi peptide iyi. Ndiye kuti, akaphatikizidwa m'thupi, amayesa kumunyenga. Zotsatira zake, thupi silikuwona kusiyana pakati pa ma enzymes awa kuchokera ku mankhwala omwe adayambitsidwa. Zimakhazikika pama receptors. Pankhaniyi, insulin imapangidwa kwambiri. Mothandizawa, wokhathamira wa glucone peptide wakumwa ndi mankhwalawa.
Popita nthawi, pamakhala kusintha kwa zinthu zachilengedwe zomwe zimayambitsa insulini. Izi zimabweretsa matenda a shuga.
Kulowa m'magazi, liraglutide imawonjezera kuchuluka kwa matupi a peptide. Zotsatira zake, kapamba ndi ntchito yake zimakhalanso zabwinobwino. Mwachilengedwe, shuga m'magazi amatsika msanga. Zakudya zomwe zimalowa m'thupi ndi chakudya zimayamba kuyamwa bwino, shuga m'magazi amakhala osakhazikika.

Kusintha kwa Mlingo

Yambani ndi 0,6 mg. Kenako imachulukitsidwa ndi kuchuluka komweko sabata iliyonse. Bweretsani kwa 3 mg ndikusiya mlingo mpaka maphunzirowo atha. Mankhwalawa amaperekedwa popanda malire a tsiku lililonse, chakudya chamasana kapena kugwiritsa ntchito mankhwala ena m'chafu, phewa kapena pamimba. Malowa a jakisoni amatha kusinthidwa, koma mlingo sasintha.

Yemwe amawonetsedwa ngati mankhwalawo

Chithandizo cha mankhwalawa chimangoperekedwa ndi dokotala.! Ikani momwemo ndipo ngati cholozera cha hypoglycemic chaphwanyidwa.

Contraindication kuti agwiritse ntchito:

• Milandu yokhala osalolera payekha imatheka.
• Osagwiritsa ntchito mtundu 1 wa shuga.
• Mitundu yambiri yaimpso ndi kwa chiwindi.
• 3 ndi 4 mtundu wa kulephera kwa mtima.
• Matumbo amkati ogwirizana ndi kutupa.
• Chithokomiro cha chithokomiro.
• Mimba

Ngati pali jakisoni wa insulin, ndiye kuti nthawi yomweyo mankhwala osavomerezeka. Ndikosayenera kugwiritsa ntchito muubwana komanso omwe adadutsa zaka 75 zaka. Mosamala kwambiri, ndikofunikira kugwiritsa ntchito mankhwalawa pamitundu yosiyanasiyana ya mtima.

Mphamvu ya kugwiritsa ntchito mankhwalawa

Kuchita kwa mankhwalawa kumadalira kuti kuyamwa kwa chakudya kuchokera m'mimba kumalepheretsa.Izi zimadzetsa kuchepa kwa chikhumbo, chomwe chimaphatikizapo kuchepa kwa kudya kwa pafupifupi 20%.
Mankhwalawa a kunenepa kwambiri amagwiritsidwa ntchito kukonzekera kwa Xenical (the yogwira mankhwala orlistat), Reduxin, kuchokera ku mankhwala atsopano a Goldline Plus (chinthu chogwiritsidwa ntchito ndi sibutramine kutengera mankhwalawa), komanso opaleshoni ya bariotric.

Tikupangizanso kuti muzidziwitsa zovuta zamankhwala amakono momwe mungakwaniritsire kulemera koyenera:

Kunenepa kwambiri ndi mdani woopsa kwa anthu amakono, kuyambira ndewu yomwe, choyambirira, simuyenera kuyiwala za zomwe zimakulimbikitsani kulimbana ndi vuto la mahomoni, polumikizana ndi katswiri wazakudya zanu komanso endocrinologist yemwe angakulembetseni molondola pulogalamu yam'tsogolo. Kudzichita nokha ndi mankhwalawa ndizoletsedwa, zomwe zingagwiritsidwe ntchito monga momwe adanenera dokotala.

Zokhudza mankhwalawa

Liraglutide yochepetsa thupi ndi chida chotsimikiziridwa komanso chotsika mtengo chomwe chidawonekera pamsika waku Russia kubwerera mu 2009. Imaloledwa kugwiritsidwa ntchito osati ku Russia, komanso ku USA ndi m'maiko ena. Wopanga chopangira Novo Nordisk adalembetsedwa ku Denmark.

Mankhwala amapezeka mu mawonekedwe a jekeseni wa subcutaneous. Cholinga chake chachikulu ndikuwongolera kapamba. Mankhwala amathandizanso kubisa kwa mitundu ina ya mahomoni omwe amachititsa kuti pakhale zotetezedwa:

• glucagon,
• insulin
• kulemera kwa thupi.

Kodi mumadziwa kuti ku United States, Saxenda ndi mankhwala achi 4 omwe amavomerezedwa kuti azigwiritsidwa ntchito ngati njira yochepetsera kunenepa kwambiri?

Onani mankhwala aliwonse awiri mwatsatanetsatane:

1. Woperewera amapezeka mu syringes yodzazidwa ndi 3 ml ya yankho. Mtengo wake wamsika ndi 158 USD. Zinali ndi Victoza, mu 2009, komwe kugwiritsa ntchito Liraglutide mu mankhwala kunayambika. Chida ichi chinakonzedwanso. Zotsatira zake, mankhwala a Saksenda adawonekera.
2. Saxenda ndi cholembera cha syringe 5 yomwe ili ndi mankhwalawo. Cholembera chilichonse chimakhala ndi 3 mg ya yankho. Chida chimakhala ndi muyeso wokhala ndi magawano ndipo chimapangidwira majekiseni angapo. Kuchuluka kwake kumatengera mlingo. Mtengo wa mankhwala opangira mankhwala kuchokera pa 340.00 mpaka 530.00 USD. Kuphatikiza pa Liraglutida, akuphatikiza:

• Propylene Glycol,
• Nátrii Hydroxídum,
• Phenol
• Sodium hydrogen phosphate dihydrate
• Madzi a jakisoni.

Saxenda, monga njira yamakono yosinthira, ili ndi zabwino zingapo pa Viktoza. Izi ndi:

• kuchepetsedwa mavuto
• kulimbana kwambiri ndi kunenepa kwambiri,
• zosavuta kugwiritsa ntchito.

Victoza poyambirira adapangidwa kuti azichiritsa matenda ashuga, chifukwa akatswiri azakudya nthawi zambiri amakonda mnzake wocheperako.

Matenda zotsatira, katundu, contraindication

Kutsitsa minofu ya adipose ndipo, chifukwa chake, kuchepa thupi, kumachitika chifukwa cha kukhazikitsa kwa njira ziwiri:

• anjala imatha
• kuchepa kwa mphamvu yamagetsi.

Gwiritsani ntchito mankhwala ochepetsa thupi Lyraglutid amapereka zotsatira zotsatirazi:

• shuga amabwerera mwakale
• chifukwa cha kuchuluka kwa ma peptides, ntchito ya pancreatic imakhala yofanana.
• kukhuta chakudya kumathamanga, pomwe thupi limatenga kuchokera kuzakudya zomwe zawonongeka zokhala ndi michere yonse mkati mwake,
• bongo limapatsidwa chisonyezo kuti kukwezedwa kwatha,
• chilakolako kuponderezana kumachitika.

Zoyipa pa kugwiritsa ntchito mankhwala okhala ndi liraglutide ndi:

• matenda a chithokomiro
• kulephera kwa mtima
• kusokonezeka ndi njira zotupa m'mimba,
• kupatuka kwa malingaliro,
• kuphwanya impso ntchito,
• matenda a chiwindi
• kapamba
• endocrine neoplasia,
• kuyamwa
• mimba
• tsankho pa zosakaniza za mankhwala,
• shuga ini.

Izi ndi zifukwa zomveka zokanira kumwa mankhwalawo. Madokotala amatchulanso zifukwa zingapo zosadziwika:

• matenda a mtima
• kumwa mankhwala okhala ndi GLP-1 (insulin, etc.),
• kutenga njira zina zolimbikitsira kuchepa thupi,
• zaka zosakwana 18 ndi zopitilira 75.

Muzochitika izi, mutha kutenga Saxenda kapena Victoza pokhapokha malinga ndi dokotala komanso moyang'aniridwa naye. Pokayikira koyamba kuti mwina pali zotsatira zoyipa, mankhwalawo amachotsedwa.

Omwe amamwa mankhwalawa nthawi zambiri amawona zovuta zingapo:

• kulakalaka kugwa, komwe kungatengedwe ngati mphamvu,
• kupuma
• mitundu yosiyanasiyana ya zolephera m'matumbo am'mimba:
• kudzimbidwa
• kutsegula m'mimba
• nsapato zokongola
• gastroesophageal Reflux,
• kupweteka
• dyspepsia
• chisangalalo
• ukufalikira
• kusanza
• nseru
• mutu
• kusowa kwamadzi
• achina,
• kukhumudwa
• kulimbikira ntchito
• ulesi
• kusiya kugwira ntchito
• thupi lawo siligwirizana
• arrhasmia,
• kukomoka.

Zotsatira zoyipa izi zimakupangitsani kukumbukira mawu oti "Kukongola kumafuna kudzipereka." Ziphokoso ndizosankha koma ndizotheka. Mutatha kumwa mankhwalawa, zonse zimayamba pang'onopang'ono.

Malangizo ogwiritsira ntchito ndi zotsatira

Wopanga wapanga malangizo ogwiritsa ntchito Liraglutide:

1. Mankhwala ayenera kuperekedwa:

• kokha mwanjira
• kamodzi pa maola 24
• pa ola lomwelo (popanda kufuna)
• jekeseni m'chiuno, m'mimba, kapena phewa.

1. Mlingo woyambirira wa 1.8 mg, pakapita nthawi, mutha kupititsidwa mpaka 3 mg.
2. Mlingo wawiri saloledwa masana.
3. Nthawi yovomerezedwa ndiku kuyambira miyezi 4 kufikira chaka (zotchulidwa ndi dokotala).
4. Ngati chifukwa chodwala ndikuchepetsa thupi, muyenera kupita kumasewera ndikupita kukadya.
5. Pamodzi ndi liraglutide, thiazolidinediones ndi metformin nthawi zambiri amaloledwa.
6. Mankhwalawa amasungidwa mufiriji pa kutentha kwapakati pa + 2 ° C (musalole kuzizira).
7. Mankhwalawa amagwiritsidwa ntchito kwa mwezi umodzi.

Mlingo umayikidwa ndi wopanga, koma adokotala amatha kusintha zina ndi zina.

Ndemanga za akatswiri azachipatala

Athandizanso kupanga chisankho, kumwa mankhwalawo kapena kuyang'ana yankho lina, ndemanga za Liraglutid za kuwonda, zolembedwa ndi madotolo. Tikuwapatsa ena a iwo:

Pimenova G.P., endocrinologist, Rostov-on-Don, zaka 12:

Liraglutide ndi amodzi mwa mankhwala omwe ndimapereka kwa odwala anga kuti achepetse shuga. Nthawi zambiri chifukwa cha mtengo wokwera wa mankhwalawo. Kufanana ndi chinthu chachikulu, kuchepa kwa cholozera cha thupi kumawonedwanso. Kuchita bwino komanso kuthamanga kwa kuchepa thupi zimadalira mwachindunji kutsatira kwa odwala pazomwe ndimalangizira, zomwe ndimapereka payekhapayekha. Zotsatira zake zimadaliranso zakudya zomwe zimagwiritsidwa ntchito. ”

Orlov E.V., zakudya, Moscow, zaka 10:

“Ndimapereka mankhwala mosamala mu Lyraglutide mosamala. Kumbali ina, si aliyense amene amatha kulipira ndalama zamtunduwu, Komano, mankhwalawa amapangidwira odwala matenda ashuga. Kumwa mankhwala othandiza popanda vuto lililonse ndikotheka ndikuyang'aniridwa ndi achipatala okha. "

Stepanova L. R., endocrinologist, MD, Murmansk, zaka 17 zokumana nazo:

"Ku chipatala chathu, Liraglutide ndi njira imodzi yochizira matenda ashuga komanso kunenepa kwambiri, komwe kumayambitsa matenda ambiri. Tsoka ilo, odwala olemera okha ndi omwe angathe kugula mankhwalawo. Mtengo wake ndiwokwera kwambiri, ndipo njira yovomerezeka imatha kupitilira chaka chimodzi. Zotsatira zake ndi kutaya kwakukulu. Komabe, ndi njira imodzi yothandiza kwambiri yothana ndi kunenepa kwambiri komanso matenda ashuga. "

Ndemanga za madotolo ndi akatswiri azaumoyo amalimbikitsa anthu omwe akufuna kuchepa thupi kuti agule mankhwala okhala ndi liraglutide.