Mankhwala a Subetta: malangizo ogwiritsira ntchito

Zina zamalonda zamankhwala: Subetta

Dzinalo Losayenerana: -

Fomu ya Mlingo: lozenges

Chithandizo: Ma antibodies ku C-terminal chidutswa cha β-subunit cha insulin receptor amatsukidwa, kuphatikiza ma antibodies a endothelial NO synthase kumayeretsedwa

Gulu la Pharmacotherapeutic: hypoglycemic ndi njira zina kuphatikiza

Katundu

Ma antibodies ku C-terminal fragment ya β-subunit kudzera mu njira ya allrateic modulation imapangitsa insulin receptor, imawonjezera chidwi chake ndi insulin komanso insulin, yomwe imayendera limodzi ndi activation ya metabolism ya insulin. Kukhalapo kwa zotsatira zapakati pa hypoglycemic mu ma antibodies kupita ku β-subunit kwawonetsedwa poyesa (kuchepa kwa kudya kwa glycemia ndi 0.7-1.4 mmol / L), pomwe kugwiritsidwa ntchito kwakutali sikunayendetsedwe ndikupanga zovuta monga hypoglycemia, acidosis, kulemera kwa thupi, hemostasis ndi hematopoiesis. Ma antibodies a endothelial NO synthase amathandizira ntchito ya endothelial NO synthase, yomwe imayendera limodzi ndi kuchuluka kwa NO, yomwe imakhala ndi endothelioprotective, imathandizira kuchepetsa kusintha kwa mtima, kuchepetsa kuphipha kwamitsempha, kuchepetsa matenda othamanga kwa magazi komanso kukonza zotumphukira zama cell. Ma antibodies a endothelial NO Syththase ali ndi kutchulidwa kwama psychotropic m'njira yotsutsa-nkhawa, anti-asthenic, michere yolimba. Pogwiritsa ntchito zigawo zikuluzikulu za kukonzekera kwa Subetta, zotsatira za synergistic pa kukhudzika kwa maselo a somatic kupita ku insulin zimawonedwa chifukwa chosagwirizana ndi NO-kudalira kwa kulowerera kwa chidziwitso cha intracellular kuchokera ku insulin receptor, yomwe imalola kuwonjezera mphamvu ya insulin mankhwala, kukhazikika kwa Mlingo womwe umagwiritsidwa ntchito ndikuchepetsa chiopsezo cha mavuto. Mankhwala amachepetsa kuopsa kwa zovuta za matenda ashuga: matenda a mtima, ma neuropathies, nephropathies.

Zisonyezero zogwiritsidwa ntchito:

Monga gawo la zovuta mankhwala a odwala matenda a shuga mellitus pamaso pa insulin kukana.

Zoyipa:

Kuchulukitsa kumvetsetsa kwamunthu pazigawo za mankhwala.

Mlingo ndi makonzedwe:

Mkati. Nthawi imodzi - piritsi 1 (khalani pakamwa mpaka itasungunuka kwathunthu, osati panthawi ya chakudya). Piritsi imayenera kusungidwa pakamwa popanda kumeza mpaka itasungunuka kwathunthu. Kukula kovomerezeka kumatsimikiziridwa ndi dokotala ndipo kumatha kusiyanasiyana kuyambira 2 mpaka 4 / tsiku - kutengera kuchuluka kwa kubwezeredwa kwa shuga.

Zotsatira zoyipa:

Zotheka zimachitika chifukwa cha kuchuluka kwa chidwi chamunthu pazigawo za mankhwala.

Mogwirizana ndi mankhwala ena:

Milandu yosagwirizana ndi mankhwala ena silinanenedwebe.

Tsiku lotha ntchito: Zaka zitatu

Mankhwala Okhala Pamalo a Pharmacy: pa kontrakitala

Kutulutsa mawonekedwe ndi kapangidwe kake

Mankhwalawa amapezeka mu mawonekedwe a lozenges: flat-cylindrical, kuyambira pafupifupi mpaka loyera, ndi notch ndi bevel, pambali yokhala ndi chilembo cholemba pali mawu akuti MATERIA MEDICA, mbali inayo - SUBETTA (ma PC 20. M'matumba, pamakatoni 1, 2 kapena 5 mapaketi ndi malangizo ogwiritsira ntchito Subetta).

Piritsi limodzi lili:

• yogwira pophika: ma antibodies ku C-terminal ya beta subunit ya insulin receptor yoyanjanitsidwa - 0,006 g, ma antibodies kuti endothelial NO (nitric oxide) synthase yoyanjana itayeretsedwa - 0,006 g (chisakanizo cha magawo atatu a mowa omwe ali ndi vuto la mankhwala 100 12, 100 30, 100 200 times),
• othandizira zigawo: isomalt, magnesium stearate, crospovidone.

Mankhwala

Subetta ndi mankhwala osokoneza bongo a hypoglycemic omwe amapangidwa kuti aphatikizidwe ndi zovuta zovuta za odwala omwe ali ndi matenda a shuga mellitus pamaso pa insulin. Limagwirira a zochita za mankhwala chifukwa cha zotsatira za synergistic mphamvu ya maselo a somatic insulin, zomwe zimachitika chifukwa chosagwirizana ndi NO-kudalira activation ya intracellular sign transduction kuchokera kwa insulin receptor. Izi zimapangitsa kuwonjezeka kwa mphamvu ya mankhwala a insulin, kumathandizira kukhazikika kwa milingo yomwe imagwiritsidwa ntchito, komanso kuchepetsa mwayi wazotsatira zoyipa.

Kudzera mwa ma processor a allostic modulation, ma antibodies mpaka C-terminal ya beta subunit azindikira insulin receptor, yomwe imawonjezera chidwi chake mpaka endulin komanso jekeseni wa insulin komanso imayendetsa kagayidwe ka glucose wodalira insulin.

Ma antibodies ku beta subunit amakhala ndi vuto lodziwika bwino la hypoglycemic (akagwidwa pamimba yopanda kanthu, pamachepa kuchuluka kwa glycemia ndi 0.7-11.4 mmol / L). Kugwiritsira ntchito kwawo kwakanthawi sikumayendetsedwa ndikupanga zotsatira zoyipa mu mawonekedwe a hypoglycemia, acidosis, hexpasis yodala ndikupanga magazi, komanso kuchuluka kwa thupi.

Zotsatira za ma antibodies a endothelial NO synthase zimapangitsa kuchuluka kwa ntchito ya endothelial NO synthase ndi zomwe zili NO, zomwe zimakhala ndi endothelioprotective. Pali kuchepa kwa kusintha kwa mtima, kuchepa kwa kuphipha kwamitsempha, kuchuluka kwa kuthamanga kwa magazi ndikofunikira, zotumphukira zamitsempha zimayenda bwino. Kuphatikiza apo, ma antibodies a endothelial NO Syththase amakhala ndi kutchulidwa kwama psychotropic kwambiri, komwe kumawonetsedwa ndi zinthu monga kuthana ndi nkhawa, anti-asthenic, ndi michere yolimbitsa.

Potengera maziko a kumwa mankhwalawa, kuopsa kwa matenda amisempha amachepetsa: mtima matenda, nephropathy, neuropathy.

Subetta, malangizo ogwiritsira ntchito: njira ndi mlingo

Mapiritsi a Subetta amatengedwa pakamwa, osameza athunthu, koma atagwira pakamwa mpaka atasungunuka kwathunthu. Pakudya, mankhwalawa sayenera kumwa.

Mlingo woyenera: 1 pc. 2-5 pa tsiku. Dokotala amakhazikitsa kuchuluka kwa kuvomerezeka payekhapayekha, poganizira kuchuluka kwa chiphuphu cha matenda ashuga.

Kutulutsa mafomu ndi kapangidwe kake

Mankhwalawa amapangidwa mwa mawonekedwe a lozenges. Ndi osalala, oyera, oyera. Pali mzere wogawa mbali imodzi. M'matumba am'manja muli mapiritsi 20. Mu katoni mukhonza kukhala 1 mpaka 5 mapaketi ndi malangizo ogwiritsira ntchito.

Piritsi 1 ili ndi 0,006 g yogwira mankhwala. Othandizira ndi: magnesium stearate, isomalt, crospovidone.

Zotsatira za pharmacological

Wothandizila wovuta ndi hypoglycemic effect. Amapangidwa kuti athandize odwala matenda ashuga ndi chitukuko cha thupi kukana insulin. Mankhwalawa ali ndi synergism pokhudzana ndi maselo a insulin omwe amatha kuzindikira. Nthawi yomweyo, mphamvu ya mankhwala a insulin imakulirakulira, ndipo chiwopsezo cha zovuta zimachepa.

Pulogalamu yogwira ndi ma antibodies ku C-terminal ya beta subunit ya insulin receptor + antibodies kuti endothelial NO synthase.

Imagonjera machitidwe a allosteric modulation (ma antibodies) amayamba kulimbikitsa chidwi cha insulin receptors. Chifukwa chake, kumva chidwi ndi zigawo zikuluzikulu kumabweretsa mphamvu yogwira ya shuga.

Mukamagwiritsa ntchito mankhwalawa, mitsempha ya mtima imachepa. Chiwopsezo chokhala ndi ma spasms a mitsempha ya mtima imachepetsedwa, zizindikiro za kuthamanga kwa magazi zimasinthidwa. Uku ndiye kukhudzidwa kwa mankhwalawa.

Mukamagwiritsa ntchito mankhwalawa, mitsempha ya mtima imachepa.

Ma antibodies kuwonjezera omwe amathandizira kukulitsa zotsatira za antiasthenic, anti-nkhawa, kuphatikiza, kukhazikika kwa magwiridwe antchito a autonomic system. Chiwopsezo cha zovuta za matenda a shuga mu mawonekedwe a mtima, ma neuropathies ndi nephropathies amachepetsa kwambiri.

Ndi chisamaliro

Chenjezo liyenera kumwedwa mwa anthu okalamba ndi ana. Mwa ana, chitetezo chokwanira chimakhala chofooka, osapangidwa kwathunthu. Ma antibodies samapangidwa mwachangu, kotero, mankhwalawa amadzipatsa muyezo wochepetsetsa komanso kungokhala bwino munthawi ya chithandizo chachikulu.

Subetta imalembedwa kwa odwala omwe ali ndi matenda a shuga, momwe insulin imatchulidwira.

Okalamba ali ndi chiopsezo chachikulu cha mtima ndi mtima. Ngati zizindikiro zonse zaumoyo zikusintha, mankhwalawo amachotsedwa.

Chenjezo liyeneranso kuchitidwa pamaso pa mbiri ya matenda a impso ndi chiwindi. Pankhaniyi, muyenera kusintha mlingo wotsatira kuchuluka kwa thanzi la munthu.

Kutulutsa mawonekedwe, ma CD ndi kapangidwe kake ka mankhwala

Subetta imapezeka mu mawonekedwe am'mapiritsi, omwe amapangidwanso kuti azizungulira pakamwa. Kapangidwe ka mankhwalawa kumaphatikizapo mitundu iwiri ya ma antibodies: ku gawo lodana ndi insulin receptors ndi endothelial synthase. Mankhwalawa amamuikidwa pabokosi lamatabwa a zidutswa makumi awiri, pamodzi ndi malangizo ogwiritsira ntchito Subetta. Mutha kugula Subetta ndi mankhwala. Mtengo wa Subetta umasiyanasiyana ku Russia.

Ndi matenda ashuga

Mlingo wa mankhwalawa zimatengera kuuma kwa matenda, ndipo mwa ana, kulemera kwa thupi kumathandizidwanso. Ngati palibe zotsutsana ndi zoyipa, tikulimbikitsidwa kuti mutenge piritsi limodzi katatu pa tsiku. Kuchuluka kwa mapiritsi patsiku kumadalira kuchuluka kwa chiphuphu chamatenda a shuga ndipo amakhazikitsidwa payekhapayekha kwa wodwala aliyense.

Zotsatira zoyipa Subetta

Mankhwalawa amaloledwa ndi magulu onse a odwala. Koma nthawi zina, zimachitika izi:

• mavuto a dyspeptic
• Hypersensitivity pazigawo,
• matupi awo sagwirizana ndi mawonekedwe a khungu totupa ndi kuyabwa.

Zotsatira zonse zoyipa zizipita pazokha mankhwala atatha. Izi ngati sizichitika, ndibwino kufunsa katswiri.

Kutenga Subetta kumatha kuyambitsa matenda osokoneza bongo.Kutenga Subetta kungayambitse kukulitsa kwa hypersensitivity pazinthuzi.
Ngati zotsatirapo zoyipa sizichoka pambuyo posiya mankhwala, ndi bwino kukaonana ndi katswiri.

Kapangidwe ka mankhwalawa

Mankhwala omwe amapanga ali ndi zigawo zikuluzikulu:

• yogwira: antibodies to C-terminal fragment of β-subunit of the insulin receptor and endothelial NO synthase,
• othandizira: isomalt, crospovidone, magnesium stearate.

Mankhwala akupezeka mu mawonekedwe a piritsi. Kumbali ina ya cholembapo pali mawu akuti MATERIA MEDICA, mbali ina - SUBETTA.

Mankhwala a Pharmacodynamic

Gulu loyamba la ma antibodies kudzera allostic modulation amatulutsa insulin receptor (IR), imathandizira kuyanjana kwake ndi insulin komanso insulin. Kuchita kumeneku kumawonetsedwa ndi kukondoweza kwa glucose metabolism wodalira insulin.

Kafukufuku awonetsa kuti ma antibodies opita ku β-subunit ali ndi katundu wofatsa wa hypoglycemic. Ngakhale izi, Subetta sanapangitse kuti:

• achina,
• acidosis
• kunenepa
• zolakwika za heestasis ndi hematopoietic ndondomeko.

Chifukwa cha ma antibodies a NO synthase, ntchito yotsiriza ikuwonjezeka. Izi zimaphatikizidwa ndi kuwonjezeka kwa kuchuluka kwa NO, komwe kumatha:

• khalani ndi chitetezo chokwanira,
• sinthani kukonzanso kwamitsempha,
• chepetsani kuphipha kwa mtima,
• sinthani kupanikizika m'mitsempha,
• Sinthani zotumphukira.

Komanso, antibodies awa amadziwika ndi kutchulidwa pang'ono kwama psychotropic, komwe kumakhala ndi anti-nkhawa, anti-asthenic ndi michere yolimba.

Kulandila "Subetta" kumakhala ndi gawo logwirizana pakuwona kwa insulin ndi maselo a somatic. Chomwe chimapangitsa izi ndi kusasinthika kwachidziwitso cha NO-kudalira chidziwitso cha IR. Amakhudzanso insulin mankhwala, imakhazikitsa Mlingo wa mankhwalawa ndikuchepetsa zovuta zoyipa.

Chifukwa cha Subetta, kukula kwa mawonetseredwe amatenda omwe amaperekedwa ndi matenda a shuga kumachepa. Izi zikuphatikiza:

• Zophwanya CCC
• neuropathy (kuwonongeka kwa zotumphukira za NS),
• nephropathy (matenda a impso).

Mlingo wambiri, zotsatira za bongo

Mankhwala opangidwa kuti agwiritsidwe ntchito pakamwa. Kapisozi umodzi amapangidwira mlingo umodzi. Iyenera kuyikidwa mumkamwa ndikudikirira mpaka isungunuke. Subetta iyenera kumwedwa musanadye chakudya.

Pafupipafupi kugwiritsa ntchito makapisozi kumatsimikiziridwa ndi adotolo potengera zomwe wodwala akuonetsa komanso kuopsa kwa matenda ashuga. Monga lamulo, mlingo wololedwa ndi makapisozi 2-4.

Milandu yama bongo osowa kwambiri. Amawonetsedwa ndi zovuta za dyspeptic, zomwe zimaputa zotulutsa zomwe zimapanga Subetta.

Njira zopewera kupewa ngozi

Mankhwala samakhudzanso wodwala kuti azitha kuwongolera makina aliwonse, komanso kuthekera kwambiri kokumbukira mavuto ovuta.

Pakadali pano, palibe malo amtundu wa Subetta pamsika wamankhwala.

Mtengo wa ma CD No. 100 umasiyanasiyana ma ruble 300.

Ngakhale kuti Subetta ali ndi mndandanda wocheperako wa contraindication ndipo alibe ndemanga zoyipa, sangagwiritsidwe ntchito ngati mankhwala omwe mungadzipange nokha.

Mlingo ndi makonzedwe

Mankhwala amaperekedwa pakamwa. Piritsi imayikidwa mkamwa, ndipo imakhalapo mpaka itasungunuka kwathunthu. Kutafuna, kugawa zigawo kapena kumeza mankhwala athunthu ndikuloledwa. Mankhwalawa amatengedwa mosasamala chakudya. Kutalika kwa nthawi yolandirira ndi kufotokozera kwa mankhwalawa amathandizidwa ndi adokotala.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Palibe chodalirika poti mankhwalawo akudutsa chotchinga ndi kulowa mkaka wa m'mawere. Chifukwa chake, mapiritsi amayikidwa pokhapokha ngati phindu kwa mayi lidzapambana zomwe zingavulaze mwana wosabadwayo.

Subetta simalimbikitsidwa kwa ana ochepera zaka zitatu.

Overdose Subetta

Kuwoneka kwa zizindikiro za bongo kumatheka pokhapokha ngati wodwala mwangozi amatenga mapiritsi angapo nthawi. Panthawi imeneyi, maonekedwe a mseru komanso kusanza, kutsegula m'mimba, komanso zovuta zina zam'mimba. Chifukwa cha kutchulidwa kwakukulu, kutenga mapiritsi angapo a Subetta nthawi imodzi kumatha kupangitsa kuti magazi achepe kwambiri, omwe ndi owopsa kwa okalamba.

Mankhwalawa amangokhala chizindikiro. Poizoni wowopsa, mankhwala obwezeretsa detoxation amachitidwa. Hemodialysis siyothandiza, popeza palibe deta pa kagayidwe ka mankhwala a chiwindi.

Kuchita ndi mankhwala ena

Palibe deta yodalirika ya momwe mankhwalawa amaphatikizidwira ndi mankhwala ena. Koma sikulimbikitsidwa kumwa mapiritsi ndi mankhwala ena kuti muchepetse matenda a shuga. Kuphatikiza apo, ndikosafunikanso kuphatikiza ndi mankhwala opangira zochizira kunenepa, mwachitsanzo ndi Dietress.

Kuyenderana ndi mowa

Simungathe kuphatikiza zakumwa zoledzeretsa ndi zakumwa zoledzeretsa. Ndi kuphatikiza uku, zizindikiro za kuledzera zimatha, ndipo mphamvu yogwiritsa ntchito mankhwalawa imachepa.

Subetta ilibe fanizo pazomwe zimagwira. Pali malo okhawo omwe amathandizira mankhwalawa omwe ali ndi vuto lofanana la hypoglycemic.

Sikulimbikitsidwa kumwa mapiritsi ndi mankhwala ena kuti muchepetse matenda a shuga.

Tsiku lotha ntchito

Ndi zaka 3 kuyambira tsiku lopangira, zomwe zikuyenera kuwonetsedwa pazomwe zimapangidwira koyambirira.

Kuwoneka kwa zizindikiro za bongo kumatheka pokhapokha ngati wodwala mwangozi amatenga mapiritsi angapo nthawi.

Ndemanga za Subetta

Popeza mankhwalawa amagwiritsidwa ntchito kwambiri ndi magulu osiyanasiyana a odwala, mutha kupeza ndemanga zambiri za izi, osasiyidwa ndi akatswiri okha, komanso ndi odwala. Kuphatikiza apo, mankhwalawa amathandizira kuchepetsa thupi ndikuwonetsetsa kuti ali pamlingo woyenera mwa kuchepetsa shuga.

Roman, wazaka 47, wa endocrinologist, ku St. Petersburg: "Nthawi zambiri ndimapereka mankhwala kwa odwala anga. Panalibe anthu omwe sanakhutire ndi momwe amathandizidwira. Odwala azindikire zomwe zimachitika pang'onopang'ono. yang'aniranini mankhwalawa, makamaka kwa ana ndi okalamba. Ngati mukuyiwala kumwa mapiritsi, kulumpha pang'ono m'magazi a magazi ndizotheka. Chifukwa chake, ndikofunika kuti musaphonye mlingo ndi kumwa mankhwalawo momveka bwino pazolinga zomwe mukufuna. "

Georgy, wazaka 53, woweruza wa matenda a ana, Saratov: "Masiku ano mankhwalawa akutchuka kwambiri. Mapiritsi ndiosavuta kumwa. Ndi ochepa, amakhudzidwa mwachangu. "kuchuluka kwa shuga m'magazi. Zotsatira zoyipa sizipezeka konse. Analogs of the yogwira mankhwala sangapezeke, choncho nthawi zina pamafunika kupereka mankhwala ena a hypoglycemic."

Mankhwala a Hypoglycemic Kodi mankhwala a shuga ndi ati?

Olga, wazaka 43, ku Moscow: "Ndidapezeka kuti ndimadwala matenda a shuga kwa nthawi yayitali. Subetta: Kunena kuti ndakhutira ndikungonena chilichonse. Zotsatira zake za mankhwalawa ndi zabwino.

Tsopano simukuyenera kuyimirira pamzere wa mankhwala, mutha kungomwa mapiritsi katatu patsiku ndikumva bwino. Sindinamve zowawa zilizonse. Kuphatikiza apo, mapiritsi amasungunuka bwino, samakhala ndi kukoma kosasangalatsa komanso fungo. Zotsika mtengo, mutha kugula chithandizo chotere. "

Vladislav, wazaka 57, Rostov-on-Don: "Sindikanatha kulandira chithandizo ndi Subetta. Choyamba, chifukwa cha zovuta kukumbukira, nthawi zambiri ndimayiwala kumwa mapiritsi. Chifukwa cha izi, ndidamva bwino .. Dokotala adandiwuza kuti ndibwino kuphatikiza mankhwalawa. ndi mankhwala ena a matenda a shuga .. Popita nthawi, zotupa zapakhungu zidayamba kuonekera.

Chilichonse chapita pambuyo pothana ndi mankhwalawo ndi chinanso. Adotolo adalongosola izi momwe thupi langa limachitikira chifukwa chakuti mankhwalawa amayamba kupangika pakapangidwe kamankhwala. Mankhwalawa sanayenere. "

Chenjezo liyenera kumwedwa.

Anna, wazaka 22, ku St. Petersburg: "Ndakhala ndikudwala matenda a shuga kuyambira ndili mwana. Chifukwa chake, ndili wachinyamata, chifukwa cha kusintha kwa mahomoni, ndidayamba kulemera msanga. Madokotala adapereka mankhwala osiyanasiyana oletsa kuchepa thupi, koma sizinathandize.

Kenako pulofesa wina analimbikitsa mapiritsi a Subetta. Anatinso kuti mankhwalawa amapangidwira kuti azikhala ndi shuga wambiri, komanso kulemera. Poyamba, sindinamve chilichonse, kupatula kungochotsa insulin. Koma kwenikweni patatha milungu iwiri, kulemera kunayamba kuchepa. Dokotalayo anakhazikitsa zakudya zapadera komanso kuchita masewera olimbitsa thupi pang'ono. Tsopano ndimatsatira malingaliro onse, ndikumva bwino komanso ndili ndi thanzi. "

Migwirizano ndi magwiritsidwe akusungidwa

Ku Moscow, Subetta amasungidwa moyenerera. Ulamuliro wa kutentha ndi madigiri makumi awiri ndi asanu, chinyezi chachibale ndi makumi asanu ndi awiri peresenti. Pewani kufikira ana ndikuwululidwa ndi dzuwa. Moyo wa alumali pakapangidwe koyambirira ndi miyezi makumi atatu ndi isanu ndi umodzi. Tsiku lotha litatha, mankhwalawo amayenera kutayidwa, chifukwa zinthu zomwe zimatayika zimataya phindu.

Chilolezo cha Pharmacy LO-77-02-010329 cha pa June 18, 2019