Insulin Insuman Bazal GT

Kuyimitsidwa kwa subcutaneous makonzedwe a 100 IU / ml

1 ml ya kuyimitsidwa kuli

ntchito yogwira - insulin ya anthu 100 IU (3,571 mg),

zokopa: 85% glycerol, protamine sulfate, metacresol, phenol, zinc chloride, sodium hydrogen phosphate dihydrate, sodium hydroxide, anaikira hydrochloric acid, madzi a jekeseni.

Kuthamangitsa mwachangu kuyimitsidwa kwa zoyera kapena pafupifupi zoyera. Chaupamwamba ndi chowonekera kapena pafupifupi chowonekera.

Mankhwala

Pharmacokinetics

Insuman® Basal GT (isofan-insulin kuyimitsidwa) ndi insulin yomwe imayamba pang'onopang'ono komanso imakhala nthawi yayitali. Pambuyo subcutaneous makonzedwe, zimachitika mkati 60 Mphindi, gawo pazoyenera zochita amawona 3-4 mawola jekeseni, zotsatira kumatenga maola 11-20.

Hafu ya moyo wa insulini kuchokera ku seramu ili pafupifupi maminiti 4-6. Imakhala yayitali kwambiri polephera kwa impso. Tiyenera kudziwa kuti pharmacokinetics ya insulin sikuwonetsa metabolic yake.

Mankhwala

Insuman® Basal HT imakhala ndi insulin yofanana ndi insulin yaumunthu, yomwe imapezedwa ndi ukadaulo wa maumboni a DNA ogwiritsa ntchito Escherichia coli.

Insuman® Bazal GT

- Amachepetsa glucose wamagazi ndikuthandizira zotsatira za anabolic, komanso amachepetsa zotsatira za catabolic

- imathandizira kayendedwe ka glucose m'maselo, komanso mapangidwe a glycogen mu minofu ndi chiwindi, zimathandizira kugwiritsa ntchito pyruvate. Amalepheretsa glycogenolysis ndi glyconeogeneis

- amalimbitsa lipogenesis mu chiwindi ndi adipose minofu ndi ziletsa lipolysis

- amalimbikitsa kumwa amino acid ndi maselo ndikuwonjezera kuphatikiza mapuloteni

- Kuchulukitsa kwa potaziyamu ndimaselo.

Mlingo ndi makonzedwe

Magazi a glucose ofunikira, kukonzekera kwa insulin kuti agwiritsidwe ntchito komanso mlingo wa mankhwala (kuchuluka kwa magawo, nthawi yogawa) amasankhidwa payekha malinga ndi kadyedwe, mulingo wakuchita zolimbitsa thupi komanso moyo wa wodwalayo.

Mlingo watsiku ndi tsiku ndi nthawi yoyendetsera

Palibe malamulo osasinthika a insulin dosing. Pafupifupi tsiku lililonse insulin ndi 0,5-1.0 IU pa kilogalamu ya odwala. Chofunikira cha metabolic cha insulin ndi 40-60% ya zomwe zimafunikira tsiku lililonse. Insuman® Bazal GT imaperekedwa kwa mphindi 45-60 mphindi asanadye.

Kusintha kwa mlingo wachiwiri

Kuwongolera kagayidwe ka metabolic kumatha kubweretsa kuchuluka kwa insulin, ndikupangitsa kuti insulin ifunike. Kuwongolera kwa dosi kungafunike ngati kusintha kwa kulemera kwa wodwalayo, momwe amakhalira, ndi zochitika zina zomwe zingapangitse kuti achuluke kwambiri a hypoglycemia kapena hyperglycemia (onani "malangizo apadera").

Magulu apadera a odwala

Kufunika kwa insulini kungachepetse vuto la chiwindi kapena matenda a impso komanso mukalamba (onani "Malangizo apadera").

Intravenous makonzedwe alibe kwathunthu.

Insuman® Basal GT imayendetsedwa mosavuta.

Kuyamwa kwa insulin ndipo, chifukwa chake, kuchepetsa mphamvu ya jakisoni kumasiyanasiyana, kutengera malo a jakisoni (mwachitsanzo, khoma lam'mimba poyerekeza ndi dera la akazi). Tsamba la jakisoni liyenera kusinthidwa nthawi iliyonse mkati mwa malo omwewo.

Mankhwala

Insuman ® Basal GT imakhala ndi insulin yofanana ndi insulin yaumunthu ndipo yopezeka ndi ma genetic engineering pogwiritsa ntchito kupsyinjika Escherichia coli K12 135 pINT90d.

Limagwirira zake insulin:

Amachepetsa kuchuluka kwa shuga m'magazi, amalimbikitsa zotsatira za anabolic komanso amachepetsa zotsatira za catabolic,

Zimawonjezera kuyendetsa shuga mkati mwa maselo ndikupanga glycogen mu minofu ndi chiwindi ndikuwongolera kugwiritsa ntchito pyruvate, tikuletsa glycogenolysis ndi glyconeogeneis,

Kuchulukitsa lipogenesis mu chiwindi ndi adipose minofu ndi ziletsa lipolysis,

Zimalimbikitsa kutulutsa kwa ma amino acid m'maselo ndi kaphatikizidwe wa mapuloteni,

Kuchulukitsa kwa potaziyamu kumaselo.

Insuman ® Bazal GT ndi insulin yochita masewera olimbitsa thupi pang'onopang'ono. Pambuyo pa utsogoleri wa sc, mphamvu ya hypoglycemic imachitika mkati mwa ola limodzi ndikufika pazokwanira mkati mwa maola 3-4. Zotsatira zimapitirira kwa maola 11 mpaka 20.

Contraindication

Hypersensitivity reaction insulin kapena zilizonse zothandiza za mankhwala, pokhapokha ngati insulini ikufunika,

Ndi chisamaliro: kulephera kwa aimpso (mwina kuchepa kwa insulini chifukwa cha kuchepa kwa insulin metabolism), odwala okalamba (kuchepa kwapang'onopang'ono kwa ntchito ya impso kungayambitse kuchepa kosafunikira kwa insulin), kulephera kwa chiwindi (insulini kufunikira kumatha kuchepa chifukwa cha kuchepa kwa mphamvu ya gluconeogeneis ndi kuchepa insulin metabolism), stenosis yayikulu yamitsempha yamagazi ndi matenda a m'magazi (mwa odwalawa, zochitika za hypoglycemic zingakhale ndi tanthauzo lapadera la matenda, i.e. K. pali chiopsezo chowonjezeka cha mtima kapena matenda a m'matumbo a hypoglycemia), odwala omwe ali ndi proliferative retinopathy, makamaka omwe sanalandire chithandizo ndi Photocoagulation (laser tiba), chifukwa ndi hypoglycemia pali chiopsezo chosakhalitsa amaurosis - khungu khungu lathunthu, odwala omwe ali ndi matendawa chifukwa matenda omwe amaphatikizana nthawi zambiri amalimbikitsa kufunika kwa insulin.

Ngati wodwala ali ndi imodzi mwa matenda kapena mikhalidwe iyi, muyenera kufunsa dokotala musanagwiritse ntchito mankhwalawa.

Mimba komanso kuyamwa

Chithandizo cha Insuman ® Basal GT panthawi yoyembekezera ziyenera kupitilizidwa. Insulin siyidutsa chotchinga. Kusunga moyenera kagayidwe kazakudya panthawi yonse yoyembekezera ndikovomerezeka kwa azimayi omwe ali ndi matenda ashuga asanabadwe, kapena amayi omwe apanga matenda a shuga.

Kufunika kwa insulin panthawi yapakati kumatha kuchepa panthawi yayitali ya kubereka ndipo nthawi zambiri kumawonjezeka panthawi yachiwiri komanso yachitatu ya amayi omwe ali ndi pakati. Pambuyo pobadwa, insulini ikucheperachepera (chiwopsezo cha hypoglycemia). Pa nthawi ya pakati komanso makamaka mukabereka mwana, kuwunika mosamala kuchuluka kwa shuga m'magazi kumafunika.

Ngati muli ndi pakati kapena mukufuna kubereka, onetsetsani kuti mwadziwitsa dokotala.

Panthawi yoyamwitsa, palibe zoletsa pazotsatira za insulin, komabe, mlingo wa insulin komanso kusintha kwa zakudya kungafunike.

Zotsatira zoyipa

Hypoglycemia. Zotsatira zoyipa kwambiri za mankhwala a insulin zimatha kupezeka ngati mlingo wa insulini womwe umathandizidwa upitilira kufunikira kwake (onani "Maupangiri Apadera"). Magawo obwerezabwereza a hypoglycemia angayambitse kukula kwa zizindikiro zamitsempha, kuphatikizapo chikomokere, onani kukokana (onani "bongo"). Kukhalitsa kwa nthawi yayitali kapena koopsa kwa hypoglycemia kumatha kukhala pachiwopsezo cha moyo.

Odwala ambiri, zizindikiro ndi mawonekedwe a neuroglycopenia atha kukhala patsogolo ndi zizindikiro za Reflex (poyankha kukulitsa hypoglycemia) kutsegulira kwa mtima wamanjenje. Nthawi zambiri, ndi kuchepa kwambiri kapena kuchepa msanga kwa kuchuluka kwa shuga m'magazi, chodabwitsa cha kutseguka kwa mphamvu yamanjenje yomvera chisoni ndikuonetsa zizindikiro zake.

Ndi kuchepa kwakukulu kwa kuchuluka kwa shuga m'magazi, kukulitsa kwa hypokalemia (zovuta kuchokera ku CCC) kapena kukulira edema ya ubongo.

Otsatirawa ndi zochitika zoyipa zomwe zimayesedwa m'magulu oyeserera omwe amadziwika ndi magulu a organic ndi kuchepa kwa zochitika: pafupipafupi kwambiri (≥1 / 10), pafupipafupi (≥1 / 100 ndi New, omwe endocrinologists amalangizira Kupitiliza kwa Matenda Atsopano! Ndi zofunika tsiku lililonse.

Mankhwalawa ndi mankhwala a Sanofi, omwe amapanga Lantus, Apidra ndi Tujeo odziwika bwino. Gawo la Insuman pamsika wa insulin ndi pafupifupi 15%. Malinga ndi anthu odwala matenda ashuga, yankho ndi losavuta kugwiritsa ntchito, lomwe limadziwika ndi mtundu wonse wapamwamba. Pali mitundu iwiri ya insulini pamzere: wa Insuman Bazal ndi waufupi wa Insuman Rapid.

Kodi mankhwalawa amagwira ntchito bwanji?

Insuman ndi insulin yopangidwa ndi anthu. Pa kukula kwa mafakitale, timadzi timene timapanga timabakiteriya. Poyerekeza ndi ma insulins omwe amagwiritsidwa ntchito kale, kupanga ma genetic kumakhala ndi zotsatira zokhazikika komanso kuyeretsa kwapamwamba.

M'mbuyomu, cholinga cha mankhwala a insulin chinali kulimbana ndi imfa. Ndi kuyamba kwa insulin ya anthu, vutoli lasintha. Tsopano tikulankhula zochepetsera chiopsezo cha zovuta komanso moyo wathunthu wa odwala. Zachidziwikire, kuti izi zitheke pama insulin analogs ndizosavuta, koma pa Insuman yolipira chindapusa cha shuga ndiyotheka. Kuti muchite izi, muyenera kuwerenga mosamala malangizo a mankhwalawo, momwe amagwirira ntchito, kuphunzira ndikusintha panthawi yake.

Matenda a shuga ndi kupsinjika kudzakhala chinthu chakale

Matenda a shuga ndi omwe amayambitsa pafupifupi 80% yonse yamikwingwirima ndi kuduladula. Anthu 7 mwa anthu 10 amafa chifukwa cha mitsempha ya mtima kapena ubongo. Pafupifupi nthawi zonse, chifukwa chomaliza chomaliza ndi chimodzimodzi - shuga wamwazi.

Shuga akhoza ndipo amayenera kugwetsedwa, apo ayi. Koma izi sizichiritsa matendawa, koma zimangothandiza kulimbana ndi kufufuza, osati zomwe zimayambitsa matendawa.

Mankhwala okhawo omwe amalimbikitsidwa mwalamulo kwa odwala matenda ashuga komanso ogwiritsidwa ntchito ndi endocrinologists pantchito yawo ndi Ji Dao shuga patch.

Kugwiritsa ntchito bwino kwa mankhwalawa, kuwerengera malinga ndi njira yokhazikika (kuchuluka kwa odwala omwe achiwonjezere kuchuluka kwa odwala omwe ali mgulu la anthu 100 omwe adachitiridwa chithandizo):

• Matenda a shuga - 95%
• Kuthetsa kwa mitsempha thrombosis - 70%
• Kuthetsa kwa kugunda kwamtima kwamphamvu - 90%
• Kuthana ndi kuthamanga kwa magazi - 92%
• Kulimbitsa tsiku, kukonza kugona usiku - 97%

Opanga Ji Dao si bungwe lazamalonda ndipo amalipiridwa ndi boma. Chifukwa chake, tsopano wokhala aliyense ali ndi mwayi wopeza mankhwalawo kuchotsera 50%.

Kuphatikizika kwa mahomoni mu kapamba amoyo wathanzi ndikosakhazikika. Kutulutsa kwakukulu kwa insulin kumachitika poyankha glucose omwe amalowa m'mitsempha yamagazi kuchokera ku chakudya. Komabe, ngati munthu ali ndi njala kapena akugona, ndiye kuti pali insulin m'magazi, ngakhale itakhala yochepa kwambiri - pamlingo wotchedwa basal. Kupanga kwa timadzi timene timayamwa ndi matenda ashuga, mankhwala othandizira amayamba. Izi nthawi zambiri zimafuna mitundu iwiri ya insulin. Mulingo woyambira umatsata Insuman Bazal, imalowa m'magazi pang'onopang'ono, kwa nthawi yayitali komanso magawo ang'onoang'ono. Shuga mutatha kudya amapangidwira kuti muchepetse Insuman Rapid, yomwe imafikira zombo mwachangu kwambiri.

Makhalidwe oyerekeza a Insumans:

Malamulo ogwiritsira ntchito

Kufunika kwa insulin ndi munthu aliyense payekha wodwala matenda ashuga. Monga lamulo, odwala omwe ali ndi matenda amtundu 2 komanso kunenepa kwambiri amafunikira mahomoni ambiri. Malinga ndi malangizo ogwiritsira ntchito, pafupifupi patsiku, odwala amapaka jekeseni 1 mpaka 1 kilogalamu ya mankhwala. Chiwerengerochi chikuphatikiza Insuman Bazal komanso Rapid. Insulin yochepa imakhala 40-60% ya zosowa zonse.

Insuman Bazal

Popeza Insuman Bazal GT imagwira ntchito osakwana tsiku limodzi, muyenera kuyikamo kawiri: m'mawa mutatha kuyeza shuga komanso musanagone. Mlingo wa makina aliwonse amawerengedwa mosiyana. Pazomwezi, pali mitundu yapadera yomwe imaganizira kukhudzidwa kwa mphamvu ya ma cell ndi glycemia. Mlingo woyenera uyenera kusunga kuchuluka kwa shuga panthawi yomwe wodwala matenda ashuga ali ndi njala.

Insuman Bazal ndi kuyimitsidwa, panthawi yosungirako imatulutsa: yankho lomveka limatsalira pamtunda, gawo loyera lili pansi. Pamaso pa jekeseni iliyonse, mankhwala osokoneza bongo muyenera kusakaniza bwino . Momwe kuyimitsidwa kumayambira, ndiye kuti mlingo womwe umafunawo udzalembetsedwa. Insuman Bazal ndiyosavuta kukonzekera kuposa makina ena apakati. Kupangitsa kusanganikirana, ma cartridge amakhala ndi mipira itatu, zomwe zimapangitsa kuti zikwaniritse bwino homogeneity wa kuyimitsidwa pamitundu 6 yokha ya cholembera.

Okonzeka kugwiritsa ntchito Insuman Bazal ali ndi utoto woyera. Chizindikiro cha kuwonongeka kwa mankhwalawa ndi mapepala, makristali, ndi mawonekedwe amtundu wina mu cartridge atasakanikirana.

Insuman Rapid

Short Insuman Rapid GT jekeseni musanadye, nthawi zambiri patsiku. Imayamba kugwira ntchito patatha mphindi 30, ndiye kuti jakisoni uyenera kuchitidwa pasadakhale. Pofuna kukonza chindapusa cha shuga, ndikofunikira kukwaniritsa zomwe zimachitika polandila magawo a insulin ndi shuga m'magazi.

Kuti muchite izi, muyenera:

1. Yambitsani chakudya chanu pang'onopang'ono ndi mapuloteni. Zakudya zomanga thupi mwachangu zimasiyidwa kumapeto kwa chakudya.
2. Idyani pang'ono pakati pa zakudya zazikulu. Pazakudya zoziziritsa kukhosi, 12-20 g yamafuta okwanira ndizokwanira.

Mlingo wa Insuman Rapid umatsimikiziridwa ndi kuchuluka kwa chakudya chamagulu m'zakudya ndi zotsatira zakumwa. Mlingo wowerengeredwa moyenera umakupatsani mwayi kuti muchotse shuga onse omwe amabwera ndi chakudya.

Kuthamanga insulini kumakhala kowonekera nthawi zonse, simuyenera kusakaniza, cholembera chitha kugwiritsa ntchito popanda kukonzekera.

Njira yolowetsera

Insuman imapangidwa ndi wopanga mu mawonekedwe a Mbale 5 ml, 3 ml cartridgeges ndi syringe pens. M'magulitsa ogulitsa ku Russia, ndizosavuta kugula mankhwala omwe amaikidwa mu zolembera za SoloStar syringe. Amakhala ndi 3 ml ya insulin ndipo sangathe kugwiritsidwa ntchito mankhwala atatha.

Momwe mungalowere Insuman:

1. Kuti muchepetse kupweteka kwa jakisoni ndikuchepetsa chiopsezo cha lipodystrophy, mankhwala omwe ali mu cholembera amayenera kukhala kutentha kwambiri.
2. Asanagwiritse ntchito, katiriji amayang'aniridwa mosamala kuti awone zowonongeka. Kuti wodwala asasokoneze mitundu ya insulini, zolembera za syringe zimalembedwa ndi mphete za utoto zofanana ndi utoto wa zolembedwa paphukusili. Insuman Bazal GT - wobiriwira, Rapid GT - wachikasu.
3. Insuman Bazal imakulungidwa pakati pa kanjedza kangapo kuti isakanikane.
4. Akutenga singano yatsopano pa jakisoni aliyense. Gwiritsani ntchito ntchito yanu kuwonongeka. Masingano ali konsekonse ali ngati zolembera za SoloStar: MicroFine, Insupen, NovoFine ndi ena. Kutalika kwa singano kumasankhidwa malinga ndi kukula kwa mafuta ochulukirapo.
5. Cholembera cha syringe chimakulolani kuti muzimudula kuyambira 1 mpaka 80 mayunitsi. Insumana, kulondola kwa dosing - 1 unit. Mwa ana ndi odwala omwe amakhala ndi zakudya zochepa zamagulu ochulukirapo, kufunikira kwa mahomoni kungakhale kochepa kwambiri, amafunikira kulondola kwapamwamba pakukhazikitsa. SoloStar siyabwino pamilandu yotere.
6. Insuman Rapid makamaka idalaswa m'mimba, Insuman Bazal - ntchafu kapena matako.
7. Pambuyo pakuyambitsa yankho, singano imasiyidwa m'thupi kwa masekondi 10 ena kuti mankhwalawo asayambe kutulutsa.
8. Mukatha kugwiritsa ntchito, singano imachotsedwa. Insulin imawopa kuwala kwa dzuwa, chifukwa chake muyenera kutseka cartridge mwachangu ndi kapu.

Zotsatira zoyipa

Ngati mankhwalawa amaperekedwa kuposa momwe amafunikira, zimachitika. Ndi omwe ali ndi vuto lotsatira kwambiri la insulin, mosasamala mtundu wa insulin yomwe imagwiritsidwa ntchito. Hypoglycemia imangokulira msanga, chifukwa chake ngakhale madontho pang'ono a shuga omwe amakhala pansi pazoyenera ayenera kuthetsedwa nthawi yomweyo.

Zotsatira zoyipa za Insuman mulinso:

Doctor of Medical Science, Mutu wa Institute of Diabetesology - Tatyana Yakovleva

Ndakhala ndikuphunzira matenda a shuga kwa zaka zambiri. Zimakhala zowopsa anthu ambiri akamwalira, ndipo makamaka amakhala olumala chifukwa cha matenda ashuga.

Ndili wokonzeka kunena uthenga wabwino - Endocrinological Research Center ya Russian Academy of Medical Science yakwanitsa kupanga mankhwala omwe amachiritsiratu matenda ashuga. Pakadali pano, kugwiritsa ntchito bwino kwa mankhwalawa kuyandikira 98%.

Nkhani ina yabwino: Unduna wa Zaumoyo wateteza kukhazikitsidwa kwa pulogalamu yapadera yomwe imalipira mtengo wa mankhwalawo. Ku Russia, odwala matenda ashuga mpaka pa Epulo 23 (kuphatikiza) nditha kuipeza - Kwa ma ruble 147 okha!

1. Chiwopsezo kwa zigawo za yankho. Nthawi zambiri zimafotokozedwa poyabwa, redness, zotupa m'dera loyang'anira. Nthawi zambiri (malinga ndi malangizo, zosakwana 1%) anaphylactic zimachitika: bronchospasm, edema, dontho dontho, mantha.
2. Kusungidwa kwa sodium. Nthawi zambiri zimawonedwa kumayambiriro kwa chithandizo, pamene shuga kuchokera pamitundu yambiri imatsika kupita kwazonse. Hypernatremia imayendera limodzi ndi edema, kuthamanga kwa magazi, ludzu, kusokonekera.
3. Kapangidwe ka ma antibodies kupita ku insulin mthupi kumadziwika ndi chithandizo chambiri cha insulin. Poterepa, kuchuluka kwa Insuman kumafunikira. Ngati mlingo womwe mukufuna ndi waukulu kwambiri, wodwalayo amamuthandizira mtundu wina wa insulin kapena mankhwala a immunosuppress.
4. Kusintha kwakukulu pakubwezeretsanso shuga kungayambitse kuwonongeka kwakanthawi.

Nthawi zambiri, thupi limazolowera pang'onopang'ono insulin, ndipo matupi awo sagwirizana. Ngati zotsatira zoyipa zikuopseza moyo (anaphylactic shock) kapena sizimatha pambuyo pa masabata awiri, ndikofunika kusintha mankhwalawo ndi analog. Insuman Bazal GT - kapena, Rapid GT -, kapena Humulin Regular. Mankhwalawa amasiyana muziperekazi. Mbiri yakuchitachita ndi yomweyo kwa iwo. Akadwala insulin yaumunthu, amasinthira ku insulin analogues.

Mtengo wa Insuman ndi wofanana ndi mtengo wamisonkho yake. Mankhwala omwe amapezeka m'matende a syringe amatenga ruble 1100. pa 15 ml (mayunitsi 1500, ma cholembera asanu). Isofan-insulin imaphatikizidwa pamndandanda wazamankhwala ofunika, momwe odwala matenda ashuga alili mwayi wolandira kwaulere .

Malangizo apadera

Hypoglycemia ndiye njira yovuta kwambiri ya insulin, chifukwa chake gawo logawika limaperekedwa potsatira malangizo a Insuman. Chiwopsezo cha kutsika koopsa kwa shuga ndizochuluka makamaka kumayambiriro kwa kugwiritsidwa ntchito kwa insulin, pomwe wodwalayo amangophunzira kuwerengetsa kuchuluka kwa mankhwalawo. Pakadali pano, kuwunika kwambiri shuga kumalimbikitsidwa: mita imagwiritsidwa ntchito osati m'mawa komanso asanadye, komanso pang'onopang'ono.

Hypoglycemia imayimitsidwa pazizindikiro zoyambirira kapena zokhala ndi shuga ochepa, ngakhale sizikhudza thanzi. Zizindikiro zowopsa: mantha, ludzu, kunjenjemera, dzanzi kapena kumva kutulutsa lilime ndi milomo, thukuta, matupa, mutu. Kuwonjezeka kwa hypoglycemia kumatha kukayikiridwa ndikukhudzika, kusadziletsa komanso kugwirizanitsa kosuntha. Munthu akasiya kuzindikira, matendawo amafooka, ndikuyamba.

Nthawi zambiri matenda obwera chifukwa cha hypoglycemia amayambiranso, pamene odwala matenda ashuga amayamba kuzindikira zizindikiro zake, ndipo kumakhala koopsa kwambiri kutsika kwina kwa shuga. Hypoglycemia pafupipafupi imafuna kusintha kwa mlingo wa Insuman. Thandizo loyamba la shuga ochepa - 20 g shuga . Mlingo uwu ukhoza kupitilira pazochulukirapo, popeza kuchuluka kwa chakudya champhamvu kwambiri kumabweretsa chiwonetsero chazovuta - hyperglycemia.

Vuto lalikulu la hyperglycemia ndi. Nthawi zambiri amakula kwa masiku angapo, choncho wodwala amakhala ndi nthawi yochitapo kanthu. Nthawi zina, kuyambira ketoacidosis kupita ku chikomokere, kumangopita maola ochepa, choncho muyenera kuchepetsa shuga yambiri itapezeka. Zolinga izi gwiritsani ntchito insuman yokha mwachangu . Monga lamulo wamba, 1 unit ikuyenera kuchepetsa glycemia ndi 2 mmol / L. Insuman. Popewa hypoglycemia, shuga mu gawo loyamba amachepetsedwa 8. Kuwongolera zomwe zimachitika kumachitika patatha maola ochepa, pomwe nthawi yovulala kale yatha.

Onetsetsani kuti mwaphunzira! Kodi mukuganiza kuti kuyamwa kwa mapiritsi ndi insulini kwa nthawi yonse yokhayo ndi njira yokhayo yosungira shuga m'manja? Sichowona! Mutha kutsimikizira izi nokha ndikuyamba kuzigwiritsa ntchito.

**** HOECHST MARION ROUSSEL Aventis Pharma Deutschland GmbH Sanofi-Aventis Deutschland GmbH / Sanofi-Aventis East Hoechst Marion Russel GmbH

Mikhalidwe yapadera

• insulin-isophan (umisiri wa majini a anthu) 3.571 mg (100 IU) Othandizira: protamine sulfate - 318 μg, metacresol (m-cresol) - 1.5 mg, phenol - 600 μg, zinc chloride - 47 μg, sodium dihydrogen phosphate dihydrate - 2.1 mg, glycerol 85% - 18.824 mg, sodium hydroxide (pakusintha pH) - 576 μg, hydrochloric acid (pakusintha pH) - 246 μg, madzi d / i - mpaka 1 ml. insulin-isophan (umisiri wa majini a anthu) 3.571 mg (100 IU) Othandizira: protamine sulfate - 318 μg, metacresol (m-cresol) - 1.5 mg, phenol - 600 μg, zinc chloride - 47 μg, sodium dihydrogen phosphate dihydrate - 2.1 mg, glycerol 85% - 18.824 mg, sodium hydroxide (pakusintha pH) - 576 μg, hydrochloric acid (pakusintha pH) - 246 μg, madzi d / i - mpaka 1 ml.

Kutulutsa mawonekedwe, kapangidwe kake ndi ma CD

Gulani Insuman Bazal GT ikhoza kukhala mu mawonekedwe a kuyimitsidwa kwa jakisoni pansi pakhungu pa mlingo wa 100ME / ml. Bokosi lirilonse lagalasi limakhala ndi 5 ml Insuman Bazal GT ndikutseka ndi kapu ya aluminiyamu yomwe imakutidwa pamwamba ndi kapu ya pulasitiki kuti itetezedwe. Pali mabotolo 5 mu makatoni. Kuphatikiza apo, mankhwalawa amapezeka mu katoni kapu ya 3 ml. Gawo limodzi limatsekedwa ndi choletsa ndipo limakutidwa ndi aluminiyamu, ndipo lachiwiri - ndi piston. Cartridge ili ndi mipira 3 yachitsulo. Makatoni asanu oterewa amapakidwa.

Zotsatira za pharmacological

Insulin imatsitsa glucose, imathandizira kupanga mapangidwe atsopano ndikuchepetsa zotsatira za catabolic. Mankhwala amalimbikitsa kusuntha kwa glucose kudzera m'maselo ndikupanga glycogen. Zotsatira zoyambitsa pansi pa khungu zimachitika mkati mwa ola limodzi, zimakhala zochuluka pambuyo pa maola atatu ndipo zimatenga maola 11 mpaka 20. Phula la T1 / 2 ndi mphindi 5, ndipo pakakhala kulephera kwa aimpso, limakula kwambiri.

Insuman Bazal GT imagwiritsidwa ntchito pa matenda ashuga, omwe amafunika kukhazikitsa insulin yowonjezera.

Bongo

Mankhwala osokoneza bongo mophatikiza, mwachitsanzo, kuyambitsa kumwa mopitirira muyeso pokhudzana ndi chakudya kapena mphamvu zomwe zimamwa, zitha kuyambitsa chiwonetsero chachikulu cha hypoglycemia, yomwe imatha kukhala chowopsa, ngakhale imfa. Zochizira milandu ya hypoglycemia yaing'onoting'ono, pamene wodwalayo amakhala ndi chikumbumtima chodziwika bwino, kuyimitsa pogwiritsa ntchito chakudya chamagulu ambiri. Mungafunike kusintha mlingo, musinthe malamulo komanso kudya pafupipafupi ndikusintha kuchuluka kwa zochitika zamasewera. Machitidwe ovuta kwambiri a hypoglycemia, omwe amatha kuphatikizidwa ndi boma la comotose, kukokana kwamphamvu kapena kuwonongeka kwa mitsempha, imatha kuyimitsidwa ndikuyang'anira kwa glucagon intramuscularly kapena subcutaneally, kapena kukhazikitsa njira yapamwamba kwambiri ya dextrose kudzera mu mtsempha. Kwa ana, kutsimikiza kwa mlingo wa dextrose kumadalira thupi lawo. Matenda a glucose akangotuluka, zingakhale zofunikira kudya chakudya chamafuta ndikuwongolera adotolo, chifukwa pambuyo pa chithandizo choyambirira cha matenda a hypoglycemia, amatha kubwereranso. Popereka mankhwala kwa ana, ndikofunikira kuyang'anitsitsa kuchuluka kwa glucose, chifukwa zitha kutheka kuti kuwonongeka kwakukuru kwa mphamvu kumakula. Milandu ya hypoglycemia yayitali kwa nthawi yayitali mutatha kugwiritsa ntchito glucagon kapena dextrose, ndikofunikira kuyika dontho lomwe lili ndi chizolowezi chambiri cha dextrose kuti mupewe milandu yakupangidwanso kwa njala. Kuphatikiza apo, ndikofunikira kulingalira kuti zina zitha kufunikira kuti munthu athe kupita kumalo osungirako odwala mozama kuti athe kuwongolera mkhalidwe wake ndikuwongolera njira zonse zochiritsira.

Kuyanjana kwa mankhwala osokoneza bongo

Kuchita kwa Insuman Bazal GT ndi mankhwala ena kumatha kuwoneka motere: 1. Ndi beta-blockers, clonidine, lithiamu salt - kuchepa kwa mphamvu ya hypoglycemic. 2. Ndi ethanol - kuchepa kwa mphamvu ya hypoglycemic, kuwonjezereka kwa chiwopsezo chokhala ndi mphamvu zamagetsi, komanso kuchuluka kwa glucose pamtengo womwe umawopseza thanzi ndi moyo. 3. Ndi pentamidine - chiwopsezo chowonjezeka cha mphamvu zam'mimba, zomwe zimatha kulowa mu hyperglycemia. 4. Ndi mankhwala achifundo - kuchepetsa kapena kuchotsa kwathunthu kwa zizindikiro za ubongo.

Mimba komanso kuyamwa

Pa nthawi ya pakati, ndikofunikira kupitiliza kumwa Insuman Bazal GT. Ndizoyenera kunena kuti insulini ilibe mphamvu yolowetsa placenta. Ndikofunika kuyendetsa kagayidwe kake ka nthawi yonse yoyembekezera kwa iwo omwe matenda a shuga amapezeka asanabadwe, komanso kwa iwo omwe mayesero amiseche amayamba kuwonekera nthawi yapakati. Mu trimester yoyamba, kufunika kwa insulini kumatha kuchepa, koma pakuwonjezereka kwa insulin yachiwiri ndi yachitatu. Pambuyo pa kubereka, kufunika kwa insulin kumachepa, zomwe zimapangitsa kuti pakhale mphamvu zambiri zakukulira mphamvu ya njala. Kuwunikira mosamala shuga kumafunikira pakatha nthawi yomweyo komanso pobereka. Pokonzekera kukhala ndi pakati komanso pakachitika, ndikofunikira kudziwitsa adotolo za izi. Musanayambe kukonzekera, muyenera kuonana ndi dokotala ndikupeza mawonekedwe onse a momwe mungakonzekere kutenga pakati, komanso pazizindikiro zoyambirira za izo. Ndikofunika kudziwa kuti nthawi yoyamwitsa palibe contraindication pakugwiritsa ntchito insulin, koma kuganizira kusintha kwa onse a insulin mlingo ndi zakudya.

Malo osungira

• khalani pamalo owuma
• Sungani kuzizira (t 2 - 5)
• osayandikira ana
• sungani pamalo amdima

• Biogulin Tape U40, Isofan Insulin World Cup, Levulin L, Levulin N, Monotard, Humulin L, Humulin N

Kutalika kwapakatikati kwa insulin yaumunthu

Pharmacokinetics

Mwa anthu athanzi, T 1/2 ya plasma insulin pafupifupi mphindi 4-6. Odwala omwe ali ndi vuto lalikulu la impso, amatenga nthawi yayitali. Komabe, ziyenera kudziwidwa kuti pharmacokinetics ya insulin sikuwonetsa metabolic yake.

Zisonyezo Insuman ® Bazal GT

Matenda a shuga odwala matenda a insulin.

Kuchiritsa katundu

Mphamvu ya Hypoglycemic ya Insuman Bazal imatheka chifukwa cha chigawo chake - insulin-isophan. Thupi lomwe limapangidwa ndi momwe limapangidwira limafanana ndi mahomoni omwe amapangidwa m'thupi la munthu. Imapezeka kudzera mujini.

Mankhwala ndi a gulu la mankhwala a sing'anga nthawi ya kuchitapo. Pambuyo makonzedwe, subcutaneous chimamangiriza kwa ena zolandilira za nembanemba wa cell, ndikupanga zovuta zina zomwe zimayambitsa njira zothandizira. Imachepetsa shuga mwakuchulukitsa kayendedwe kake, imathandizira mayamwidwe, kuletsa kaphatikizidwe ka chiwindi, ndikuwongolera njira za metabolic ndi kutenga nawo mbali.

Kutalika kwa mphamvu ya mankhwalawa kumatengera kuthamanga komwe insulin imalowa mu thupi, mlingo, malo a jekeseni, komanso njira yoyendetsera. Chifukwa chake, insulin imagwira ntchito makamaka osati mu odwala matenda ashuga osiyanasiyana, koma ngakhale mwa wodwala m'modzi.

Malingaliro apamwamba a isofan: nthawi yoyambira - ola limodzi ndi theka atatha kubayidwa, mphamvu yayikulu imawonetsedwa pakadutsa maola 4-12, nthawi ya hypoglycemic - mpaka 1 tsiku.

Mankhwalawa amagawidwa pamtundu uliwonse, osatha kudutsa mkaka ndi placenta. Amagwiritsidwa ntchito mochuluka m'chiwindi ndi impso. Amathira mkodzo.

Kuchita mankhwala osokoneza bongo

Pa nthawi ya insulin, Insuman Bazal GT iyenera kukumbukiridwa kuti ikaphatikizidwa ndi mankhwala ena, kusintha kwa zotsatira za hypoglycemic kapena kusokoneza kwamankhwala ena kwamankhwala ena kumachitika:

• Mphamvu ya Insuman's hypoglycemic imakonzedwa ndikukula ngati ikuphatikizidwa ndi mankhwala ochepetsa shuga a pakamwa, ma AIn inhibitors, iMAO, Disoprimide, salicylates, anabolics, mankhwala omwe ali ndi mahomoni achimuna, Fluoxetine, Fenfluramine, Ifosfamide, sulfonamides, Amphetamine ndi tetetamine.
• Kuphatikizidwa ndi GCS, mankhwala okodzetsa, corticotropin, Danazole, glucagon, mahomoni (estrogens, gestagens), sympathomimetics, zinthu za chithokomiro, zotuluka za phenothiazine, barbiturates ndi mankhwala ena onse zimachepetsa mphamvu ya insulin.
• Mukaphatikizidwa ndi BAB, Clonidine, mchere wa lithiamu, zochita za Insuman Bazal ndizosatheka kuneneratu: zotsatira za hypo- kapena hyperglycemic zingayambike.
• Ethanol amachita pakukonzekera insulini komanso mosakonzekera: zotsatira za Insuman zitha kuchuluka kapena kuchepa. Tiyenera kudziwa kuti ngati wodwalayo achepetsa thupi, ndiye kuti zakumwa zakumwa zoledzeretsa kapena mankhwala osokoneza bongo, mlingo wake umatha kutsika mpaka kufika povuta, zomwe zitha kuwononga thanzi komanso moyo wa odwala matenda ashuga.

Zotsatira zoyipa

Pogwiritsa ntchito mankhwalawa, ndikofunikira kukumbukira kuti insulin Bazal imatha kuyambitsa zovuta pa matenda ashuga.

Zotsatira zoyipa kwambiri ndi insulin. Amayamba ngati mugwiritsa ntchito mlingo womwe umakhala wambiri kuposa momwe thupi limafunira insulin. Mobwerezabwereza milandu yambiri ya kugwa kwa glucose imathandizira kukulitsa kwamisempha yamitsempha, yomwe imatha kutsagana ndi kupweteka, chikomokere. Kuukila kwa nthawi yayitali komanso koopsa kumatha kupangitsa kuti wodwalayo afe.

Ngati kuchepa kwa ndende ya glucose kwachitika modabwitsa, izi zitha kuyambitsa hypokalemia ndi zovuta za CVS ndi / kapena edema yamatumbo.

Kuphatikiza pa hypoglycemia, odwala matenda ashuga amakhalanso ndi zotsatirapo zina zosayenera, zowonetsedwa mwanjira yolakwika ya ziwalo zamkati ndi machitidwe:

• Kuwonetsedwa kwa ziwopsezo: anaphylaxis, zotengera pakhungu, Quincke's edema, bronchospasm, antibody mapangidwe (kusintha kwa insulin kungafunike).
• CCC: dontho la kuthamanga kwa magazi.
• Njira za metabolism: edema, sodium owonjezera m'thupi.
• Zowoneka m'maso: kuwonongeka kwakanthawi kochepa, kuwonongeka kwakanthawi kwa retinopathy, kuwonongeka kwa mitsempha ya maso kapena retina, ndikutsatiridwa ndi khungu kwakanthawi kapena kosatha.
• Khungu ndi subcutaneous minofu: lipodystrophy (yokhala ndi jekeseni wokhazikika m'malo amodzi), chifukwa - kulowetsedwa kwa insulin.
• Matenda ena: kufupika pamalo a jakisoni, kuyabwa, kupweteka, urticaria, kutupa kapena kutupa, kutupa.