Diabefarm - malangizo a boma ogwiritsira ntchito

MALANGIZO
ntchito zamankhwala

Nambala yolembetsa:

Dzina la malonda: Diabefarm ®

Dzinalo Losayenerana: gliclazide

Mlingo: mapiritsi

Kupanga:
Piritsi 1 ili
Chithandizo: gliclazide 80 mg
Othandizira: lactose monohydrate (mkaka wa shuga), povidone, magnesium stearate.

Kufotokozera
Mapiritsi oyera kapena oyera okhala ndi chikasu chachikasu ndi amiyala pang'onopang'ono wokhala ndi bevel komanso chiwopsezo chokhala ndi mtanda.

Gulu la Pharmacotherapeutic: hypoglycemic wothandizira pakamwa makonzedwe a gulu la sulfonylurea a m'badwo wachiwiri

Nambala ya ATX: A10VB09

Zotsatira za pharmacological
Mankhwala
Glyclazide imathandizira kubisalira kwa insulin ndi ma pancreatic β-cell, imakulitsa mphamvu ya insulin-secretory ya glucose, ndikuwonjezera chidwi cha zotumphukira zimakhala ku insulin. Imalimbikitsa ntchito ya intracellular michere - minofu glycogen synthetase. Kuchepetsa nthawi kuyambira nthawi yakudya mpaka pakuyamba kwa insulin. Kubwezeretsanso nsonga zoyambirira za insulin katulutsidwe (mosiyana ndi zotumphukira zina za sulfonylurea, zomwe zimakhudza gawo lachiwonetsero chachiwiri). Amachepetsa kuchuluka kwa gluprose wa postprandial.
Kuphatikiza pa kukhudza kagayidwe kazakudya, kumapangitsanso kukoka kwa michere: kumachepetsa kuphatikiza mapulateleti ndi kusakanikirana, kupatsanso mphamvu ya mtima, kumalepheretsa kukula kwa micothrombosis ndi atherossteosis, ndikuyambiranso njira ya parietal fibrinolysis. Amachepetsa zamitsempha yama cell receptor ku adrenaline. Imachepetsa kukula kwa matenda ashuga retinopathy pa siteji ya ieproliferative. Ndi matenda a shuga a nephropathy omwe amagwiritsidwa ntchito kwa nthawi yayitali, pali kuchepa kwakukulu kwa proteinuria. Siziwonjezera kukwera kwa thupi, chifukwa imakhala ndi mphamvu pakatundu woyambirira wa insulin katemera ndipo samayambitsa hyperinsulinemia, imathandizira kuchepetsa kulemera kwa odwala onenepa kwambiri ngati ali ndi zakudya zoyenera. Amakhala ndi anti-atherogenic katundu, amachepetsa kuchuluka kwa cholesterol yathunthu m'magazi.
Pharmacokinetics
Pambuyo pakukonzekera pakamwa, imalowa mwachangu m'mimba. Mafuta ndi okwera. Pambuyo pakamwa 80 mg, pazipita ndende m'magazi (2.2-8 /g / ml) zimatheka pambuyo pafupifupi maola 4, pambuyo pa makonzedwe a 40 mg, kuchuluka kwakukulu m'magazi (2-3 μg / ml) kumachitika pambuyo pa maola 2-3 ndi mapuloteni a plasma - 85-97%, voliyumu yogawa - 0,35 l / kg. Kuyananira kwamwazi m'magazi kumafika patatha masiku awiri. Zimapukusidwa mu chiwindi, ndikupanga ma metabolites a 8.
Kuchuluka kwa metabolite yayikulu yomwe imapezeka m'magazi ndi 2-3% ya kuchuluka kwa mankhwala omwe amwedwa, alibe hypoglycemic effect, koma bwino. Imafukusidwa ndi impso - 70% mu mawonekedwe a metabolites, ochepera 1% mwanjira yosasinthika, kudzera m'matumbo - 12% mu mawonekedwe a metabolites.
Hafu ya moyo ndi maola 8 mpaka 20.

Zizindikiro zogwiritsidwa ntchito
Type 2 shuga mellitus mwa akulu kuphatikiza mankhwala othandizira kudya komanso zolimbitsa thupi zolimbitsa thupi zomwe sizingatheke.

Contraindication
Hypersensitivity a mankhwalawa, lembani 1 shuga mellitus, matenda ashuga ketoacidosis, matenda a shuga, matenda ashuga, hyperosmolar chikomokere, hepatic komanso / kapena kulephera kwa aimpso, kulowererapo kwakukulu, kuvulala kwambiri, ndi zina zofunika pa insulin. m'mimba, machitidwe limodzi ndi malabsorption chakudya, kukula kwa hypoglycemia (matenda opatsirana), leukopenia, kutenga pakati, kuyamwitsa, ana ozrast kwa zaka 18.

Ndi chisamaliro (kufunikira kowunikira mosamala ndi kusankha kwa mankhwalawa) kumayendetsedwa ngati matenda a febrile, uchidakwa komanso matenda a chithokomiro.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwalawa ali contraindicated pa mimba komanso kudya.
Mimba ikachitika, mankhwalawa amayenera kuyimitsidwa nthawi yomweyo.

Mlingo ndi makonzedwe
Mlingo wa mankhwalawa umayikidwa payekhapayekha, kutengera zaka za wodwalayo, mawonetseredwe amtundu wa matenda komanso msanga wa kudya magazi ndi ma 2 maola mutatha kudya. Mlingo woyamba wa tsiku lililonse ndi 80 mg, pafupifupi tsiku lililonse ndi 160 mg, ndipo mlingo waukulu wa tsiku ndi tsiku ndi 320 mg. Diabefarm amatengedwa pakamwa katatu pa tsiku (m'mawa ndi madzulo) mphindi 30-60 asanadye.

Zotsatira zoyipa
Hypoglycemia (pofuna kuthana ndi mankhwalawa komanso kudya mokwanira): kupweteka mutu, kumva kuti watopa, kunjala, thukuta, kufooka, nkhawa, kusakhazikika, kuchepa kwa chidwi ndikuchepetsa, kupsinjika, kuwonongeka kwa mawonekedwe, aphasia, kunjenjemera, kusokonezeka kwa malingaliro, chizungulire , kulephera kudziletsa, kupuma, kukhumudwa, kupsinjika, kusazindikira, kupuma pang'ono, bradycardia.
Zotsatira zoyipa: kuyabwa, urticaria, zotupa za maculopapular.
Kuchokera ku ziwalo za hemopoietic: kuchepa magazi, thrombocytopenia, leukopenia.
Kuchokera m'mimba: dyspepsia (nseru, kutsegula m'mimba, kumva kupsinjika kwa epigastrium), anorexia - zovuta zimachepetsa mukamadya, kuwonongeka kwa chiwindi ntchito (cholestatic jaundice, kuchuluka kwa "chiwindi" transaminases).

Bongo
Zizindikiro: hypoglycemia ndikotheka, mpaka kukula kwa hypoglycemic coma.
Chithandizo: ngati wodwalayo akudziwa, tengani chakudya cham'mimba chambiri (shuga) mkati, ali ndi vuto losazindikira, 40% dextrose (glucose) yankho limathandizidwa kudzera mu 1-2 mg ya glucagon intramuscularly. Pambuyo pakupezanso chikumbumtima, wodwalayo ayenera kupatsidwa chakudya chambiri m'zakudya zomanga thupi (pofuna kupewa kukonzanso kwa hypoglycemia). Ndi ubongo edema, mannitol ndi dexamethasone.

Kuchita ndi mankhwala ena
Angiotensin-converting enzyme inhibitors (Captopril, enalapril), H2-histamine receptor blockers (cimetidine), mankhwala antifungal (miconazole, fluconazole), mankhwala osapinga a antiidal omwe amachititsa kuti ma protein azikhala ndi matenda a Diabeficma. (ethionamide), salicylates, coumarin anticoagulants, anabolic steroids, beta-blockers, cyclophosphamide, chloramphenicol, monoamine oxidase inhibitors, su fanilamidy yaitali kanthu, fenfluramine, fluoxetine, pentoxifylline, guanethidine, theophylline, mankhwala kuti ndigwire tubular katulutsidwe, reserpine, bromocriptine, disopyramide, pyridoxine, allopurinol, Mowa ndi etanolsoderzhaschie kukonzekera, komanso mankhwala ena hypoglycemic (acarbose, biguanides, insulin).
Tasiya mphamvu ya hypoglycemic ya Diabefarma barbiturates, glucocorticosteroids, sympathomimetics (epinephrine, clonidine, ritodrine, salbutamol, terbutaline), phenytoin, pang'onopang'ono calcium blockers, carbonic anhydrase inhibitors, thiazide azolefendendane dioleanezane diolebetsetsetsetse. , diazoxide, isoniazid, morphine, glucagon, rifampicin, mahomoni a chithokomiro, mchere wa lithiamu, mu milingo yayitali - nicotinic acid, chlorpromazine, estrogens ndi njira zakulera zamkamwa zomwe zimakhala nazo.
Mukamacheza ndi ethanol, kugwiritsidwa ntchito ngati disulfiram ndikotheka.
Diabefarm imawonjezera chiopsezo chamitsempha yamagazi yam'mimba pamene imamwa glycosides yamtima.
Beta-blockers, clonidine, reserpine, guanethidine amatha kuphimba mawonetseredwe azachipatala a hypoglycemia.
Mankhwala omwe amalepheretsa mafupa a hematopoiesis kuonjezera chiopsezo cha myelosuppression.

Malangizo apadera
Mankhwala a Diabefarm amachitika limodzi ndi kalori wotsika, wokhala ndi carb wotsika. Ndikofunikira kuwunika pafupipafupi glucose omwe ali m'magazi pamimba yopanda kanthu ndikatha kudya.
Pankhani yopangira opaleshoni kapena kuwonongeka kwa matenda ashuga, ndikofunikira kulingalira za momwe mungagwiritsire ntchito kukonzekera kwa insulin.
Ndikofunikira kuchenjeza odwala za chiwopsezo chowonjezereka cha hypoglycemia ngati mutatenga mankhwala a ethanol, omwe si a antiidal. Pankhani ya ethanol, amathanso kukhala ndi discriram-like syndrome (kupweteka kwam'mimba, nseru, kusanza, kupweteka mutu).
Mukufuna kusintha kwa kumwa kwa thupi kapena kwamunthu, kusintha kwakudya
Makamaka omwe akhudzidwa ndi zochitika za mankhwala a hypoglycemic ndi anthu okalamba, odwala omwe salandira chakudya chokwanira, odwala ofooka, odwala omwe ali ndi vuto logona pituitary-adrenal.
Kumayambiriro kwa chithandizo, pakusankha kwa odwala omwe ali ndi vuto lokhala ndi hypoglycemia, sikulimbikitsidwa kuchita zochitika zofunikira kwambiri komanso kuthamanga kwa zochitika zama psychomotor.

Kutulutsa Fomu
Mapiritsi a 80 mg
Pa mapiritsi 10 mumtambo wokutira kuchokera ku filimu ya polyvinyl chloride ndi zojambulazo zotayidwa za aluminium.
3 kapena 6 matuza okhala ndi malangizo ogwiritsira ntchito amaikidwa pakatoni.

Malo osungira
Lembani B. Malo owuma, amdima pamtunda wosaposa 25 ° C.
Pewani kufikira ana.

Tsiku lotha ntchito
Zaka 2
Osagwiritsa ntchito tsiku lanu litatha.

Mankhwala Okhala Pamalo a Pharmacy
Ndi mankhwala.

Zodandaula ziyenera kupita kwa wopanga:
FARMAKOR PRODUCTION LLC, Russia
Adilesi Yopanga:
198216, St. Petersburg, Leninsky Prospect, d.140, lit. F
Adilesi yovomerezeka:
194021, St. Petersburg, 2nd Murinsky Prospect, 41, lit. A