Kodi Mungathe Kuthana ndi Matenda A shuga?

Nthawi zina, MSCs yotulutsidwa ku adipose minofu ndi yotchuka kwambiri:

• m'malo omwe kupatukana kwa maselo a hematopoietic tsinde ndikosatheka kapena kosafunikira (matenda ena, zaka, kupatukana kambiri komwe kunachitidwa kale),
• matenda ena (mtima, shuga mellitus), pomwe ma cellular pawokha amathandizira pakuthandizira

Maselo a Adipose Stem

Tizilombo ta Adipose ndi zinthu zachilengedwe zomwe zimapezeka mosavuta poyerekeza ndi marongo, komwe ndi gwero lalikulu la MSC. Ma MSC omwe amapezeka mu minofu ya adipose amakhala bwino kuti agwiritsidwe ntchito mu traumatology ndi orthopedics, chifukwa amasiyanitsa bwino kwambiri m'maselo am'mafupa. Kuphatikiza apo, ma Mips a adipose amatha kulimbikitsa kukula kwa mtima chifukwa chobisalira cha vascular endothelial grow factor (VEGF), chomwe chimawonetsera kugwiritsa ntchito kwawo bwino matenda monga m'munsi miyendo ischemia.

Makamaka ali ndi chidwi immunosuppress momwe ma MSC amagwiritsidwira ntchito molingana ndi ma MSC pochizira matenda a immunopathological, osati okhwima kwambiri monga momwe kumalumikizira motsutsana ndi kuchitapo kwa mtundu woyamba wa matenda a shuga, komanso monga wamba, mwachitsanzo. Ma cell a Mesenchymal stem cell (MSCs) amadziwika kuti amatha kulepheretsa magwiridwe antchito a T-lymphocyte, B-lymphocyte, maselo a dendritic ndi maselo wakupha (NK) maselo, ndipo njirayi imagwira ntchito ndi lingaliro la mayankho.

Zonsezi zimapangitsa MSC kukhala othandizira pochizira matenda ambiri a autoimmune ndipo, choyambirira, TYPE 1 DIABETES mwa akulu ndi ana. Chofunikira kwambiri mwa ma MSC ndi kuchepa kwa thupi kwawo ndipo, kuposa pamenepo, kukhoza kwawo kupondereza kuyankha kwa chitetezo cha mthupi, zomwe ndizofunikira kwambiri pochita mitundu ina yonse ya ma allogeneic transplantations.

Tikagulitsidwa mumitsempha yama cell kapena michere yoyera ya ubongo, maselo am'mimba am'mimba amathandizira kulowa mu minyewa yamitsempha yamanjenje ndikusiyanitsa ndikuchokera mu mzera wa cell wa glial kapena neuronal. Kuphatikiza apo, pali umboni wa transdifferentiation wa MSCs mu hematopoietic tsinde maselo onse mu vitro ndi vivo. Ndi kusanthula mwakuya, mu maphunziro amodzi, kutsika kwakanthawi kwambiri kwa MSC kunatsimikiziridwa, komwe kumadziwonetsera mu kuthekera kwawo kusiyanitsa zinthu zakuthambo, ma oligodendrocyte, ma neuron, ma mtima, maselo osalala a minofu.

Kafukufuku wambiri pakukula kwa transdifferentiation wa MSC mu vitro ndi vivo, zadziwika kuti ma mesenchymal progenitors ochulukitsa amachokera m'mafupa amamasiyanitsidwa m'mizere yama cell omwe amapanga mafupa, cartilage, minofu, mantha ndi adipose, komanso tendons ndi stroma yothandizira hematopoiesis.

KUMBUKIRANI, KWA CHOLINGA CAKUKHUMUDWA KUGWIRITSA NTCHITO NTCHITO YOPHUNZITSIRA NDIPONSO ZOSAVUTA, ZINSINSI ZOSIYANASIYANA (ZOTSATIRA), ZINSINSI ZABWINO.

Kuyambira Januware 2015, chithandizo cham'mimba chokhala ndi zigawo za adipose ndizotchipa, ndichizolowezi chopanda malire zaka (zokhazokha ndizovuta za adipose minofu).

Odwala ena, inde, amayesa kupeza njira yotsika mtengo kwambiri yochitira njirayi ndi "kutsata momwemo." Chowonadi ndi chakuti ukadaulo suyimirira. Pali kusiyana kwakukulu pakupezeka kwa chikhalidwe cha maselo kwa miyezi ingapo ku Belarus kapena "pompopompo" ku China komanso kwamakono kochitidwa ku Thailand ndi Japan. Nthawi zambiri timabwera kwa anthu omwe amabwera kuti atibweretse ku China ndi Hong Kong popanda pasipoti ya foni. Ndimalongosola kuti maselo a stem sakhala m'malo abwinobwino pa kutentha wamba. Pali njira zofunika kwambiri zolimidwa, kuzizira, thawing, mayendedwe ndi kuziika kuchokera kumalamulo awa sizingachokeretu pagulu.

Muyenera kusamala ndikuyamba mutsimikizire za bungwe lomwe mukucheza nawo. Timawonetseranso odwala athu pawunikulopu ndikuwonetsera masiyanidwe amtunduwu kuti awa ndi maselo a tsinde. Chifukwa chiyani? Pali zolemba zakale pamene ku Moscow, bungwe lolimba lomwe lili ndi ziphaso zambiri zovomerezeka komanso zovomerezeka, lidapereka chilichonse kwa odwala, koma osakhala maselo.

Ichi ndichifukwa chake timasankha mwanzeru anthu ochita nawo osati mapepala, koma zotsatira. Osawopa kufunsa! Komabe (tsoka, likuyenera dziko lathu), thupi la munthu likuyang'anira mosamala chilichonse chomwe chatulutsidwa. Kukhazikitsa chikhalidwe chopereka, osati chongofuna kuvomereza, ndizotheka kungoyambira pano, ngati tikufuna kuti zitheke popanda zovuta, ndipo makamaka sizowona kugwiritsa ntchito maselo oyambira: chomera, nyama ndi zina. Kalanga ine, sindimachita nthabwala - ali ndi chidwi, chifukwa kutsatsa koteroko kumachitika nthawi ndi nthawi.

Kwa iwo omwe akufuna kutsimikiza mwakuya kwa maselo a tsinde mu mtundu 1 shuga (hematopoietic):