Mankhwala Pentoxifylline 100: malangizo ntchito

Pentoxifylline 100 ndi mankhwala ogwiritsidwa ntchito pochiza matenda omwe amaphatikizidwa ndi kuchuluka kwa magazi. Imakhala ndi zotsutsana ndi zoyipa, chifukwa chake zimayikidwa mutaphunzira zotsatira za kusanthula.

Kutulutsa mawonekedwe ndi kapangidwe kake

Mankhwala amatha kuwoneka ngati:

1. Njira yothetsera kulowetsedwa kwa mtsempha wamkati ndi kwamkati. 1 ml muli 0,1 ga pentoxifylline, sodium kolorayidi njira, monovalent sodium phosphate, madzi a jekeseni. Mankhwalawa ali ndi mawonekedwe amadzimadzi osakhala opanda khungu omwe amawatsanulira ma ampoules 5 galasi. Katemera wama carton amakhala ndi ma ampoules 10 komanso malangizo.
2. Mapiritsiwa amaphatikizidwa ndi filimu ya pinki yosungunuka. Iliyonse imakhala ndi 100 mg ya pentoxifylline, stearic acid, povidone, wowuma chimanga, shuga mkaka, cellulose ufa, cellacephate, titanium dioxide, mafuta a castor, mafuta paraffin, talc, njuchi. Phukusili limaphatikizapo mapiritsi 10, 30, 50 kapena 60.

Pentoxifylline 100

Pentoxifylline ili ndi izi:

• kusintha kwa zotumphukira mtima,
• Amasintha magazi m'magazi,
• linalake ndipo tikulephera phosphodiesterase, kukulitsa kuchuluka kwa adenosine monophosphate m'mapulatifomu ndi adenosine triphosphate m'magazi ofiira,
• imachulukitsa kuchuluka kwa mphamvu yomwe imatulutsidwa ndi ma cell am'magazi, yomwe imathandizira pakukula kwamitsempha yamagazi,
• Imachepetsa zotumphukira mtima,
• kumawonjezera zotuluka zamtima popanda kukhudza kugunda kwa mtima,
• kumawonjezera mipata ya mitsempha yayikulu, kupatsa mpweya mu minofu ya mtima,
• imakulitsa mitsempha yam'mapapo, ndikudzaza magazi ndi mpweya,
• amachulukitsa kuchuluka kwa magazi akuyenda m'chigawo cham'bale,
• amachepetsa zamitsempha yamagazi magazi, amalepheretsa kuphatikizika kwa magazi, kumawonjezera maselo ofiira a m'magazi,
• Amasintha magazi kuti azikhala ischemic,
• amachotsa spasms ya ng'ombe minofu yolumikizana ndi kutsekeka kwa mitsempha yam'munsi.

Ndi makonzedwe apakamwa ndi makolo, pentoxifylline imalowa m'chiwindi, pomwe imasinthidwa kukhala ma metabolites awiri okhala ndi zofanana zofanana ndi zomwe zimayamba. Kupezeka kwakukulu kwa mankhwalawa m'magazi kumatsimikiziridwa pambuyo pa mphindi 90-120. Kuchotsa theka moyo kumatenga 3 hours. Zambiri zomwe zimagwiritsidwa ntchito zimapukutidwa ndi impso, gawo lotsala la pentoxifylline limasiya thupi ndi mkodzo.

Zizindikiro Pentoxifylline 100

Mndandanda wazomwe zikuyambitsa mankhwalawa umaphatikizapo:

• zovuta zamagazi zomwe zimakhudzana ndi zotumphukira kapena matenda a shuga.
• zotupa za ischemic zama minofu ya muubongo,
• encephalopathies yolumikizana ndi atherosulinosis ya mitsempha ya magazi ndi ngozi ya pachimake ya ubongo.
• Matenda a Raynaud
• kuperewera kwa zakudya m'thupi komwe kumakhudzana ndikuphwanya ntchito za mtima zam'matumbo (zilonda zam'mimba, frostbite, gangrene, matenda a post-thrombophlebitis),
• kusokoneza endarteritis,
• kusokonezeka m'matumbo a fundus ndi kufinya kwa diso,
• kutaya kwa makutu komwe kumayambitsidwa ndi vuto la mtima.

Momwe angatenge

Njira yogwiritsira ntchito imatengera mtundu wa mankhwalawa:

1. Mapiritsi amatengedwa mukatha kudya. Amameza osafuna kutafuna, ndikutsukidwa ndi madzi okwanira. Mlingo wovomerezeka tsiku lililonse ndi 600 mg. Iagawidwa pawiri. Pambuyo pakukula, mlingo umachepetsedwa ndikukonza (300 mg patsiku). Njira ya mankhwala kumatenga masiku 7-14. Mlingo wa tsiku ndi tsiku sayenera kupitilira 12 mapiritsi.
2. Njira yothetsera kulowetsedwa. Nthawi ya ndondomeko, wodwalayo ayenera kukhala pamalo apamwamba. Njira yothetsera vutoli imaperekedwa pang'onopang'ono. Musanagwiritse ntchito, zomwe zili pamapulogalamuwa zimasinthidwa mchikwama ndi 250-500 ml ya saline kapena dextrose solution. 300 mg ya pentoxifylline amatumizidwa patsiku. Pogwiritsa ntchito mankhwala osokoneza bongo, 5 ml ya mankhwalawa imasakanizidwa ndi 20-50 ml ya isotonic solution. Mitsempha yamatumbo ikagundika, pentoxifylline singailowe mu chotupa cha carotid.

Zotsatira zoyipa za Pentoxifylline 100

Mukamagwiritsa ntchito Pentoxifylline, mudzakumana ndi:

• mavuto am'mitsempha yamavuto (kupweteka kutsogolo ndi kwakanthawi, chizungulire, malingaliro osokoneza, kugona tulo tulo komanso kugona tulo masana, matenda opatsirana),
• Zizindikiro zowonongeka pakhungu ndi minyewa yofewa (kufupika kwa khungu, kutentha kwa nkhope ndi chifuwa, kutupira kwa minofu yolowerera, kuchuluka kwa msomali),
• kuphwanya ntchito za m'mimba thirakiti (kusowa kudya, kusokonezeka kwamatumbo, kusokonekera kwa ndulu, kuwononga maselo a chiwindi),
• kuchepa kowoneka bwino, scotoma,
• mtima matenda a mtima kusokonezeka kwa mtima, kupweteka mumtima, kuchuluka kwa angina kuukira, ochepa hypotension),
• kusokonekera kwa hematopoietic dongosolo (kuchepa kwa kuchuluka kwa mapulosi ndi leukocytes, kuchuluka kwa prothrombin nthawi, magazi amkamwa ndi mucous nembanemba, matumbo, m'mphuno ndi uterine magazi,
• Matenda oopsa (redness ndi kuyabwa kwa khungu, totupa ngati ming'oma, kutupa kwa nkhope ndi larynx, mawonekedwe a anaphylactoid),
• kuchuluka kwa chiwindi michere ndi zamchere phosphatase.