Ndemanga za Tevastor

Tevastor imapangidwa ngati mapiritsi, utoto wamafilimu (ma PC 10. M'matumba, pamatayala okhala ndi matuza atatu kapena 9):

• Mlingo wa 5 mg: wozungulira, biconvex, wolemba mbali ina ndi "N", mbali inayo ndi "5", makanema ojambulira amachokera ku kuwala wachikasu-lalanje mpaka lalanje (utoto wamtambo umaloledwa), pakati poyera mpaka mtundu woyera
• Mlingo wa 10 mg: kuzungulira, biconvex, cholemba mbali imodzi ndi "N", mbali inayo ndi "10", chipolopolo cha filimuyi chimachokera ku pinki kupita pinki, pakati kuyambira oyera mpaka oyera amakhala osiyanitsidwa ndi nthawi yopuma,
• Mlingo wa 20 mg: kuzungulira, biconvex, cholembedwa mbali imodzi ndi "N", mbali inayo ndi "20", filimu ya filimuyi imachokera ku pinki kupita ku pinki, pakati kuchokera oyera mpaka oyera amakhala osiyanitsidwa ndi nthawi yopuma,
• Mlingo wa 40 mg: chowulungika, cholemba mbali imodzi ndi "N", mbali inayo ndi "40", chipolopolo cha filimuyi chimachokera ku pinki kupita pinki, pakati kuyambira oyera mpaka oyera amakhala osiyanitsidwa ndi nthawi yopuma.

Piritsi limodzi mu 1 mg la 5 lili:

• yogwira pophika: rosuvastatin mu mawonekedwe a calcium wa rosuvastatin - 5.21 mg,
• othandizira: microcrystalline cellulose, lactose, povidone-KZO, crospovidone, sodium stearyl fumarate,
• Opadry II 85P23426 lalanje lalanje: titanium dioxide (E171), pang'ono hydrolyzed polyvinyl mowa, talc, macrogol-3350, utoto wa chitsulo oxide wakuda (E172), utoto wa iron utoto wachikasu (E172), dzuwa kulowa kwa dzuwa chikasu (E110).

Piritsi limodzi mwa kuchuluka kwa 10, 20 kapena 40 mg lili:

• yogwira pophika: rosuvastatin mu mawonekedwe a calcium rosuvastatin - 10.42, 20.83 kapena 41.67 mg,
• othandizira: microcrystalline cellulose, lactose, povidone-KZO, crospovidone, sodium stearyl fumarate,
• casing Opadry II 85P24155 pinki: titanium dioxide (E171), pang'ono hydrolyzed polyvinyl mowa, talc, macrogol-3350, utoto - iron oxide chikasu (E172), iron oxide red (E172), indigo carmine aluminium varnish (E132), azorubine aluminiyamu. E 122).

Pharmacodynamics ndi pharmacokinetics

Tevastor ndi choletsa mpikisano HMG-CoA reductase ndi kusankha. Imagwira pachimake. Zomwe zimagwira zimawonjezera kuchuluka kwa hepatic LDL zolandilira ndipo chimalimbikitsa kugwidwa ndi chinyengo LDL. Zimayambitsa zopinga za kaphatikizidwe VLDL, chifukwa chomwe chiwerengerocho LDLndi VLDL kukana.

Mankhwala Amachepetsa Mankhokwe HS-non-HDL, HS-LDL, triglycerides, HS-VLDLP, TG-VLDLP, apolipoprotein B ndi okwana xckumawonjezera chidwi HS-HDL, apolipoprotein A-1. Amachepetsa chiwerengero:

• okwana xcndiHS-HDL,
• HS-non-HDL ndi HS-HDL,
• apolipoprotein B ndi apolipoprotein A-1,
• HS-LDL ndi HS-HDL.

Mphamvu ya mankhwalawa imayamba kuonekera pakadutsa masiku asanu ndi awiri atayamba kuyamwa. Pambuyo pa masabata angapo, 90% ya mphamvu yayikulu imatheka. Zotsatira za 100% zimawonedwa kumapeto kwa mwezi woyang'anira ndipo zimayendetsedwa ndikugwiritsa ntchito pafupipafupi malinga ndi malangizo.

Pazitali kwambiri pazogwiritsa ntchito mankhwala plasma anati pafupifupi maola 5 mutatha kumwa mapiritsi. Bioavailability pafupifupi 20%.

Chithandizo chomwe chimadziunjikira kwambiri m'chiwindi. Kuyankhulana ndi mapuloteni a plasma pafupifupi 90%.

Kwakukulu isoenzymekagayidwe – CYP2C9. Mu biotransfform rosuvastatinamapangidwa N-desmethyl ndi lactone metabolites. Zotsirizazo sizothandiza. N-desmethyl pafupifupi osagwira kwenikweni kuposa rosuvastatin.

Pafupifupi 90% ya mankhwala othandizira amachotsedwa mu ndowe. Ndalama zotsalazo zimaponyedwa mkodzo. Kutha kwa theka-moyo ndi maola 19. Ndi kuchuluka kwa mankhwalawa, sasintha.

Pankhani yaukali kulephera kwa aimpso zomwe zimagwiritsidwa ntchito mu plasma zimakwera katatu, komanso mulingo N-desmethyl - kasanu ndi kanayi. At hemodialysis mulingo rosuvastatinmu plasma pafupifupi 50% apamwamba.

Zizindikiro zogwiritsidwa ntchito

Mankhwalawa amagwiritsidwa ntchito:

• choyambirirakapena Hypercholesterolemia wosakanikiranakomanso hypertriglyceridemiangati njira yowonjezerapo pakudya, ngati zakudya ndi zina sizokwanira,
• kufunika kopewa matenda oyambamtima: vuto la mtima, ochepa kusintha, sitiroko - wodwala wachikulire alibe zizindikiro zamankhwala Matenda a mtima wa Ischemic, koma pali chiwopsezo chowonjezereka cha zotere, ndipo chiopsezo chimodzi chilipo (koyambirira) Matenda a mtima wa Ischemic m'mabanja mbiri, ochepa matenda oopsa, kusuta, milingo yochepetsedwa HS-HDL),
• banja homozygous hypercholesterolemia ngati njira yowonjezera kudya kapena lipid kutsikamankhwalawa (komanso munthawi yomwe chithandizo chotere sichili choyenera),
• kufunika kuchepetsa pang'onopang'ono chitukuko atherosulinosis monga njira yowonjezerapo yazakudya.

Contraindication

Zoyipa zogwiritsidwa ntchito pa mankhwalawa zimatha kukhala zosiyana kutengera mlingo.

Mapiritsi a 5-20 mg, zotsutsana zotsatirazi zilipo:

• matenda a chiwindi
• tsankho lactose,
• kuvulala kwambiri aimpso,
• nyere,
• shuga galactose malabsorptionLactase akusowa
• mimba,
• Hypersensitivityku zigawo za njira
• kuphwanya kwambiri chiwindi (osati kuphunzira),
• myopathy,
• kusowa kwa njira zodalirika zodzitetezera kuti musatenge pakati,
• ana ochepera zaka 18.

40 mg mapiritsi sangathe kugwiritsidwa ntchito pazotsatirazi:

• matenda a chiwindi
• lactose tsankho,
• kupezeka kwa zinthu zoopsa myopathies kapena rhabdomyolysis(myotoxicitymukamagwiritsa ntchito HMG-Co-A-reductase zoletsa kapena michere mu mbirikusanthula kwamunthu kapena banja za matenda amisempha, kulephera kwa aimpsokumwa pafupipafupi hypothyroidism, mikhalidwe imayambitsa kuwonjezeka kwa zinthu rosuvastatinm'magazi)
• mimba,
• kusowa kwa njira zodalirika zotetezera kuti mwana asatenge pakati,
• nyere,
• ana ochepera zaka 18
• HypersensitivityZamankhwala
• kukanika kwambiri kwa chiwindi,
• shuga galactose malabsorptionLactase akusowa
• Mtundu waku Asia.

Mosamala, mapiritsi a 5-10 mg ayenera kumwedwa ndi odwala amtundu waku Asia, ngati pali zovuta za myopathies/rhabdomyolysis, anthu azaka zopitilira 65, komanso matenda a chiwindi mbirikuvulala ochepa hypotensionzovuta za endocrine zovuta, mikhalidwe yomwe imatsogolera kuwonjezeka kwa zomwe zili rosuvastatinmu plasma sepsiszolemetsa kagayidwekuphwanya, njira zochulukirapo zochitira opaleshoni, kugwidwa kosalamulirika, kwakukulu electrolytekuphwanya malamulo.

Mapiritsi a 40 mg amagwiritsidwa ntchito mosamala mu matenda a chiwindi mbiri, kulephera kwa aimpso, ochepa hypotension, kuvulala, mavuto akulu a endocrine, zaka 65, sepsiszolemetsa kagayidwekuphwanya, njira zochulukirapo zochitira opaleshoni, kugwidwa kosalamulirika, kwakukulu electrolyte kuphwanya malamulo.

Malangizo ogwiritsira ntchito Tevastor (Njira ndi Mlingo)

Mapiritsi amatengedwa pakamwa. Kuti muyambe kulandira chithandizo, muyezo wa tsiku wa 10 mg umalimbikitsidwa. Ngati ndi kotheka, pakatha mwezi umodzi amathanso kuwonjezeka mpaka 20 mg. Mankhwala mu mlingo wa 40 mg ayenera kumwedwa moyang'aniridwa ndi katswiri, chifukwa pali chiopsezo chachikulu cha mavuto. Malangizo ogwiritsira ntchito Tevastor akuwonetsa kuti kumwa mapiritsi a 40 mg ndi kotheka pokhapokha ngati pali zovuta hypercholesterolemiakomanso kuthekera kwakukulu mtimapamene 20 mg kwa mwezi siothandiza kokwanira. Ndi kuchuluka kwa mankhwalawa, komanso pambuyo pa milungu 2-4 mutamwa mankhwalawa, ndikofunikira kuyang'anira mawonetsedwe a mafuta kagayidwe.

Malangizo ogwiritsira ntchito Tevastor akuti amalandila nthawi iliyonse komanso mosasamala za chakudya. Mankhwalawa amezedwa lonse, kutsukidwa ndimadzi pang'ono, osafuna kutafuna. Ndikosatheka kupera mapiritsi, pokhapokha ngati pakufunika kumwa Mlingo wa 5 mg, piritsi la 10 mg lingagawidwe pawiri.

Pochita mankhwala ndi Tevastor, zakudya za hypolipidemic ziyenera kuyang'aniridwa.

Ali ndi zaka 65, odwala omwe gene polymorphism SLC01B1, anthu amtundu waku Asia, komanso ngati matendawo angayambitse matenda aimpso, ndikofunika kuyamba kumwa mlingo wochepa kwambiri wa 5 mg.

Odwala omwe akuwonetsa kukonzekera myopathies, kumayambiriro kwa maphunziro muyenera kutenga 5 mg. Pang'onopang'ono, mlingo umakwera mpaka 10-20 mg.

Bongo

Kugwiritsa ntchito pamodzi mankhwala ambiri tsiku lililonse sikuti kumapangitsa kuti masinthidwe a mapiritsi a pharmacokinetic rosuvastatin.

Chithandizo cha mankhwala osokoneza bongo ndi chizindikiro. Ndikofunikira kuyang'anira ntchito ndi chiwindi KFK. Zapadera mankhwala kulibe.

Kuchita

Akaphatikizidwa ndi otsutsavitamini K ulamuliro wofunikira INR, popeza kuchuluka kwa mankhwalawa kwamankhwala kungayambitse kuchuluka INR ndi prothrombin nthawi, komanso kuthetsedwera kwa mankhwala kapena kuchepetsa mankhwalawa, m'malo mwake, kuchepa INR.

Kuyanjana ndi Gemfibrozil kumawonjezera zili rosuvastatinplasma 2 times.

Kusankhidwa ndi maantacidkuphatikiza zotayidwa ndi magnesium hydroxidezimayambitsa kuchepa kwa mulingo rosuvastatinmu plasma ndi 50%. Zotsatira zake sizitchulidwa kwenikweni ngati mungayang'anire pakati pa kudya kwa maola awiri.

Erythromycin kumapangitsa kuchepa AUC rosuvastatin ndi 20%. Kuphatikiza apo, kuchuluka kwakukulu pazogwira ntchitoyo kumachepetsedwa ndi 30%.

Phwando kulera kwamlomondalama zimachuluka AUC norchedrel ndi ethinyl estradiol, motero, ndi 26% ndi 34%.

Mwina chitukuko myopathieszimawonjezeka lipid-kutsitsaMlingo nicotinic acid ndi micherendi kugwiritsa ntchito munthawi yomweyo HMG-CoA reductase inhibitors. Tengani mapiritsi 40 mg nthawi imodzi mafupa chosokoneza.

Zoletsa mapuloteni zimapangitsa kuwonjezereka kwa kuchuluka kwa yogwira chigawo cha Tevastor pafupifupi nthawi 5. Kuphatikiza uku sikulimbikitsidwa.

Simungathe kuphatikiza Tevastor ndi Cyclosporin chifukwa cha kuthekera kwachitukuko myopathies. Ngati makonzedwe apamwezi a ndalama izi ndiwosapeweka, ndikofunika kuti osapitilira 5 mg patsiku.

Zolemba za Tevastor

Zolemba za Tevastor zotsatirazi zimadziwika, momwe kapangidwe kazomwe amagwira ntchito ndi mawonekedwe a kumasulidwa zikugwirizana:

Onsewa ali ndi mawonekedwe awo ogwiritsira ntchito ndipo sayenera kugwiritsidwa ntchito popanda mankhwala a dokotala.

Tevastor nthawi zambiri amalimbikitsidwa m'mafakisoni anthu akatembenukira kwa anzawo otsika mtengo. Poyerekeza, mtengo wa mankhwala wotchuka Crestor10 mg - pafupifupi 1300 rubles. Nthawi yomweyo, mtengo wa Tevastor 10 mg ndi ma ruble 470.

Pharmacokinetics

Makhalidwe a Pharmacokinetic a rosuvastatin:

• mayamwidwe: Kukwaniritsa kwa Cmax (ndende yayikulu) m'madzi a m'magazi kumachitika pafupifupi maola 5 pambuyo pakukonzekera kwamlomo pakamwa, chizindikiro cha bioavailability pafupifupi 20%,
• kugawa: mpaka 90% ya rosuvastatin amamanga mapuloteni a plasma, mokulira kwambiri ndi albumin, thunthu limadziunjikira m'chiwindi (chiwalo chachikulu cha kapangidwe ka Xc ndi catabolism ya Xs-LDL), voliyumu yogawa (Vd) ili pafupifupi 134 l,
• kagayidwe: rosuvastatin biotransforms pang'ono (mpaka 10% ya mankhwalawa omwe atengedwa), chifukwa ndi gawo lopanda chapakati pazogwiritsa ntchito za michere ya cytochrome P450. CYP2C9 imakhala ngati isoenzyme yayikulu yomwe imakhudzidwa ndi metabolism ya rosuvastatin. Pazochepera, isoenzymes CYP2C19, CYP3A4 ndi CYP2D6 akutenga nawo mbali ndondoyi. Ma metabolites odziwika bwino a rosuvastatin: N-dismethyl - omwe ntchito yake ndi theka la rosuvastatin, lactone metabolites - omwe amachokera ku pharmacologic. Kuletsa kuyendayenda kwa HMG-CoA reductase kopitilira 90% kumatsimikiziridwa ndi zochitika zamatenda a rosuvastatin, otsalawo ndi metabolites ake,
• chimbudzi: theka-moyo (T_1/2) ili pafupifupi maora 19. Mtengo wa T_1/2 sasintha ndi kuchuluka kwa mankhwala. Mpaka 90% ya mankhwalawa amachotsedwa ndowe sizinasinthidwe, zinthu zonsezo zimathiridwa mkodzo. Pafupifupi chilolezo chamadzi

50 l / h (yokhala ndi kusintha kosiyanasiyana - 21.7%). Pokonzekera kutenga kwa hepatic rosuvastatin, monga momwe zimakhalira ndi ma inhibitors ena a HMG-CoA reductase, anionic membrane chonyamula Xc amakhudzidwa, yemwe ali ndi gawo lofunikira kwambiri pakuchotsa chinthu.

Pharmacokinetics wa rosuvastatin m'magulu apadera odwala:

• Kulephera kwa aimpso: kufatsa komanso kwapakati - zisonyezo za plasma ndende ya rosuvastatin ndi N-dysmethyl sizimasintha, zimafotokozedwa mwamphamvu, ndi creatinine chilolezo (CC) zosakwana 30 ml / min, - kuchuluka kwa plasma kwa rosuvastatin ndi katatu kuposa, metabolite yake yogwira, N -dismethyl, kuchulukitsa maulendo 9, ndipo odwala hemodialysis, okwera amakhala pafupifupi 50% kuposa odzipereka athanzi,
• kulephera kwa chiwindi (kuloza pamlingo wa Mwana-Pugh): ≤ Mfundo 7 - kuwonjezeka kwa T_1/2 osadziwika, 8-9 - odwala osachepera awiri anali ndi kuwonjezeka kwa T_1/2osachepera 2, ≥ 9 - palibe chogwiritsa,
• mtundu: Anthu aku Japan ndi aku China omwe amakhala ku Asia akuwonetsa kuwonjezeka kuwirikiza kawiri m'dera lomwe lili pansi pa nthawi ya ndende (AUC), poyerekeza ndi ziwonetsero za odwala a mtundu wa Europe omwe amakhala ku Europe ndi Asia. Mphamvu ya majini komanso zachilengedwe pazosiyanazi za mapiritsi a pharmacokinetic sizinapezeke. Kuwunikira komwe kumakhala pakati pamafuko osiyanasiyana a odwala: Hispanics, azungu, akuda, aku America - sikuwonetsera kusiyana kwakukulu pamikhalidwe yamapilisi
• m`badwo ndi jenda: palibe kwambiri kukhudzidwa kwa pharmacokinetic machitidwe a rosuvastatin.

5 mg, 10 mg ndi 20 mg mapiritsi

• kukanika kwambiri kwa chiwindi (≥ 9 pamakwerero a Mwana-Pugh), chifukwa chosadziwa zambiri,
• matenda a chiwindi mu gawo logwira, kuphatikiza kuwonjezereka kwa ntchito ya ma enzymes a chiwindi kapena kuwonjezeka kwa nthawi zopitilira 3 poyerekeza ndi malire apamwamba abwinobwino (VGN),
• kuvulala kwambiri kwa impso (CC 60 ml / min), mbiri yodwala matenda a chiwindi, sepsis, hypotension yokhudzana ndi ubongo, kuchuluka kwa maopaleshoni, kuvulala, metabolic yayikulu, endocrine kapena electrolyte kusokonezeka, kugwidwa kosalamulirika, komanso okalamba wazaka zopitilira 65.

Malangizo ogwiritsira ntchito Tevastor: njira ndi mlingo

Tevastor adapangira pakamwa. Mapiritsi sayenera kutafunidwa ndikuphwanyidwa, ayenera kumezedwa lonse ndikutsukidwa ndi madzi. Ngati mukufuna kumwa rosuvastatin pa mlingo wa 5 mg, piritsi pa 10 mg liyenera kugawidwa pakati. Mlingo wothandizila pawokha sunayang'ane mzere wa circadian, komanso zakudya.

Asanayambe kumwa Tevastor, wodwalayo ayenera kuyamba kutsatira zakudya zotsika za lipid, zomwe ziyenera kupitilizidwa panthawi yonse ya mankhwalawa.

Mlingo wa rosuvastatin amasankhidwa payekhapayekha ndipo zimatengera chiwonetsero chazachipatala ndikuyankha kwa wodwalayo, poganizira zomwe akutsimikizira pakadali pano.

Kwa odwala omwe akuyamba kumwa mankhwalawo, kapena osamutsidwa kuchokera ku kutenga zina za HMG-CoA reductase inhibitors, mlingo woyambirira wa 5 kapena 10 mg kamodzi patsiku umalimbikitsidwa. Kusankha kwake kumadalira cholesterol zomwe zingachitike komanso chiopsezo chotenga matenda a mtima ndi kutha kwa mavuto. Ngati ndi kotheka, pakatha milungu 4, mlingo wa Tevastor ukhoza kuchuluka.

Ngati matenda oopsa a hypercholesterolemia ndi chiwopsezo chachikulu cha matenda amtima (makamaka odwala hypercholesterolemia), pomwe zotsatira zosafunikira sizinachitike ndi chithandizo cha rosuvastatin pa 20 mg kwa milungu 4, mlingo uyenera kuchuluka mpaka 40 mg moyang'aniridwa ndi dokotala ( chifukwa cha chiopsezo chowonjezeka). Odwala omwe amalandira mapiritsi a 40 mg ayenera kuyang'aniridwa bwino. Pambuyo kukulitsa mlingo wa mankhwalawa komanso / kapena masabata awiri atatenga Tevastor, ndikofunikira kuyang'anira kagayidwe ka lipid.

Odwala omwe ali mu mpikisano waku Asia, tikulimbikitsidwa kuti ayambe mankhwala ndi Tevastor ndi 5 mg, mapiritsi a 40 mg ndi otsutsana.

Musamamwe Tevastor muyezo wa 40 mg kwa odwala omwe ali ndi vuto la kuthekera kwa myopathy, ndipo pofotokoza mapiritsi a 10 ndi 20 mg, tikulimbikitsidwa kuti muyambe kulandira chithandizo cha 5 mg.

Ma polymorphism a genetic: onyamula genotype SLC01B1 (OATP1B1) s.521CC ndi genotype ABCG2 (BCCR) C.421AA ali ndi chiwonetsero chowonjezeka (AUC) ku rosuvastatin poyerekeza ndi onyamula genotype SLC01B1 C.521TT ndi genotype ABCG2 s.421CC. Chifukwa chake, kwa odwala omwe ali ndi genotypes c.521SS ndi C.421AA, tikulimbikitsidwa kutenga Tevastor kamodzi patsiku pa mlingo waukulu wa 20 mg.

Chifukwa chomangika kwa rosuvastatin kumapuloteni osiyanasiyana oyendetsa (mwachitsanzo, OATP1B1 ndi BCRP), kugwiritsa ntchito pamodzi kwa Tevastor ndi cyclosporine ndi HIV proteinase inhibitors (kuphatikizapo ritonavir kuphatikiza ndi atazanavir, lopinavir) kumawonjezera mwayi wa myopathy / rhabdomyolysis. Zomwe zimafunikira kuganizira njira yothandizira mankhwalawa kapena kusiya kwakanthawi mankhwala. Ngati sizotheka kupewa kugwiritsa ntchito mankhwalawa munthawi imeneyi, ndikofunikira kuyesa phindu / chiopsezo cha lingaliro lachipatala ndikuganiza zochepetsa mlingo wa Tevastor.

Zotsatira zoyipa

Zotsatira zoyipa zomwe zimawonedwa ndi rosuvastatin nthawi zambiri zimakhala zofatsa komanso zofupika, ndipo zimachitika pafupipafupi, monganso zina za HMG-CoA reductase inhibitors, zimadalira kumwa kwambiri.

Kuchulukitsa kwa zoyipidwa ndi makalasi a organic (pamlingo: zoposa 1/100, koma osakwana 1/10 - nthawi zambiri, opitilira 1/1000, koma osakwana 1/100 - pafupipafupi, oposa 1/10 000, koma osakwana 1/1000 - kawirikawiri, zosakwana 1/10 000 - zosowa kwambiri, ndizosatheka kuwerengera malinga ndi zomwe zilipo - kuchuluka kwakeko sikudziwika):

• chitetezo chamthupi: kawirikawiri - hypersensitivity zimachitika, mpaka angioedema,
• endocrine dongosolo: nthawi zambiri - mtundu 2 matenda a shuga,
• pakati mantha dongosolo: Nthawi zambiri - chizungulire, kupweteka mutu,
• kugaya chakudya dongosolo: Nthawi zambiri - nseru, kudzimbidwa, kupweteka pamimba, kawirikawiri - kapamba,
• Khungu ndi mafuta osunthika: pafupipafupi - zidzolo, kuyabwa pakhungu, urticaria,
• dongosolo la minofu ndi mafupa: Nthawi zambiri - myalgia, kawirikawiri - myopathy (kuphatikizapo myositis), rhabdomyolysis, kugwiritsidwa ntchito kwa Tevastor pamankhwala onse (makamaka 20 mg) - myalgia, myopathy (kuphatikiza myositis), nthawi zina - rhabdomyolysis ndi / wopanda pachimake aimpso kulephera, kuchuluka kochokera mu ntchito ya creatine phosphokinase (CPK), munthawi zambiri - pang'ono, asymptomatic komanso kwakanthawi. Ndi kuwonjezeka kwa ntchito ya VGN ya CPK nthawi 5 kapena kuposerapo, chithandizo chokhala ndi rosuvastatin chiyenera kuyimitsidwa kwakanthawi,
• kwamikodzo dongosolo: proteinuria - kusintha kwakukuru mumapuloteni mumkodzo (kuchoka kwathunthu kapena kupezeka kwa trace kuchuluka kwa ++ kapena kuposa) kunalembedwa mu zosakwana 1% za odwala omwe amalandira 10-20 mg wa rosuvastatin, ndipo

3% akulandira mlingo wa 40 mg. Nthawi zambiri, proteinuria imachepa kapena kutha nthawi ya mankhwalawa ndipo siziwonjezera kapena kufalikira kwa matenda a impso omwe alipo.

Kukula kwakubwera kwa mavuto a Tevastor malinga ndi ntchito yotsatsa:

• magazi ndi zamitsempha yamafuta: pafupipafupi osadziwika - thrombocytopenia,
• makina ogaya: kawirikawiri - kuchuluka kwa michere ya chiwindi, osowa kwambiri - jaundice, hepatitis, kusadziwika pafupipafupi - kutsekula m'mimba,
• dongosolo la minofu ndi mafupa: osowa kwambiri - arthralgia, osadziwika pafupipafupi - immuno-mediated necrotizing myopathy,
• pakati mantha dongosolo: osowa kwambiri - polyneuropathy, kuiwala kukumbukira.
• kupuma dongosolo: pafupipafupi osadziwika - kupuma movutikira, chifuwa,
• kwamikodzo: chosowa kwambiri - hematuria,
• khungu ndi mafuta osunthika: ma frequency osadziwika - Stevens-Johnson syndrome,
• uchembere wabwino: pafupipafupi - gynecomastia,
• zochita zina: ma frequency osadziwika - zotumphukira edema.

Zotsatira zotsatirazi zidawonedwa chifukwa chogwiritsa ntchito ma statin ena: kukomoka, kugona, kusokonezeka kwa tulo (kuphatikizapo kusowa tulo komanso zolakwika), munthawi zina - matenda am'kati mwa mapapo, makamaka chifukwa chogwiritsa ntchito mankhwala kwa nthawi yayitali.

Ndemanga za Tevastor

Ndemanga za Tevastor ndizabwino. Anthu omwe amamwa mankhwalawa kuti amakhala ngati sanasinthe cholesterol patatha pafupifupi milungu itatu kuyambira poyambira kukhazikitsa.

Ndemanga za madotolo za Tevastor ndi zabwino. Nthawi zambiri amalimbikitsa kuti mankhwalawa aku Israel akhale analogue to mtengo Krestor.

Kutsitsa Mkulu Cholesterol ndi Tevastor

Zhuravlev Nikolay Yuryevich

Tevastor ndi mankhwala omwe ali m'gulu la ma statins ndipo amathandizira kuchepetsa kuchuluka kwa lipoproteins yapansi, komanso kuchepetsa magazi m'thupi.

Chofunikira chachikulu cha Tevastor ndi rosuvastatin. Kodi mankhwalawa amagwira ntchito bwanji?

Amadziwika kuti m'thupi la munthu mumakhala mafuta omwe amakhudza thanzi lake: amakhala pamakoma amitsempha yamagazi, amapanga zolembera, amachepetsa minofu ya m'thupi komanso mtima umagwira.

Chithandizo cha mankhwala ndi Tevastor ndicholinga chofuna kukhudza chiwindi, komwe, komwe, zimapangitsa kuti mafuta asokonekere (lipoproteins).

Zotsatira zodziwika zoyambirira za mankhwalawa zimawonekera patatha sabata pambuyo pa kuyamba kwa mankhwalawa, ndipo patatha mwezi umodzi mutha kuwunika kwathunthu kuchuluka kwake.

Kuwunika, kuyezetsa magazi kumachitika nthawi zonse, kuwonetsa kusintha kwa ndende yamagazi amitundu yosiyanasiyana ya lipoprotein.

Kuphatikiza pa hypolipidemic effect, rosuvastatin imathandizanso kukomoka kwa endothelial (komwe kumatchulidwa ngati chizindikiritso choyambirira cha kupezeka kwa atherosulinosis), kukonza zinthu zam'kati zamwazi ndi magazi.

Malangizo apadera

Proteinuria, makamaka ya chiyambi cha impso, yomwe imapezeka mu kuyezetsa, imawoneka mwa odwala omwe amamwa mankhwala a 40 mg kapena kupitilira, nthawi zambiri imakhala yochepa m'thupi ndipo sichizindikiro chakulephera kwa impso kapena pachimake. Matenda onse obanika a impso amadziwika mukamamwa rosuvastatin pa 40 mg, motero kugwiritsa ntchito Tevastor pa 40 mg pamafunika kuwunika kwa aimpso.

Zilonda zamafupa monga myalgia, myopathy, ndipo nthawi zina, rhabdomyolysis, amawonedwa mwa odwala omwe amatenga Tevastor pa 20 mg kapena kupitilira. Zolemba za rhabdomyolysis zomwe sizipezeka kawirikawiri ndizophatikizira zaetetibe ndi HMG-CoA reductase inhibitors. Chiwopsezo cha rhabdomyolysis, chonse cha rosuvastatin mankhwala komanso ndi zina za HMG-CoA reductase inhibitors, zimawonjezeka ndi mlingo wa 40 mg.

Ntchito za CPK siziyenera kutsimikiziridwa pambuyo pakuchita masewera olimbitsa thupi kwambiri, komanso chifukwa cha zifukwa zina zowonjezera zomwe zikuchitika mu ntchito yake chifukwa chakusokonekera kwa zizindikiro. Ntchito yoyamba ya CPK ikachuluka kwambiri (≥ 5 VGN), patatha masiku 5-7 ndikofunikira kubwereza muyeso. Simuyenera kuyamba kutenga Tevastor ngati cheke chachiwiri chikutsimikizira ntchito yoyamba ya CPK (≥ 5 VGN).

Odwala ayenera kudziwa kufunika kofotokozera dokotalayo za mawonekedwe omwe sanawonekere kale, kupweteka kwa minofu ya etiology yosadziwika, kufooka ndi / kapena kukomoka, makamaka akaphatikizidwa ndi malaise ndi fever. Therapy imayimitsidwa pomwe ntchito za CPK zikukwera nthawi 5 kuposa VGN kapena pamaso pamavuto akulu amisala omwe amayambitsa kusasinthika kosalekeza. Pambuyo pakutha kwa zizindikiritso ndi kusintha kwa ntchito za KFK, funso la kugwiritsa ntchito rosuvastatin muyezo wocheperako komanso moyang'aniridwa likuyenera kuganiziridwanso. Sikoyenera kuchita zowunikira pafupipafupi za ntchito za CPK pakalibe zizindikiro.

Musanayambe chithandizo komanso pakatha miyezi itatu ya chithandizo, muyenera kudziwa kuti chiwindi chimayambitsa matenda.

Kukopa pa kuthekera koyendetsa magalimoto ndi njira zowerengeka

Kafukufuku wokhudzana ndi mphamvu ya rosuvastatin pa luso lozama komanso kuthamanga kwa zochitika zama psychomotor sizinachitike. Koma pochita zinthu zowopsa, kuphatikizapo kuyendetsa galimoto, ziyenera kukumbukiridwa kuti chizungulire nchotheka ndi chithandizo cha Tevastor.

Mimba komanso kuyamwa

Tevastor imayesedwa kuti ichiritse amayi apakati ndi oyamwitsa. Ndipo ngati mukuganiza kuti muli ndi pakati pamankhwala, mankhwalawa ayenera kuyimitsidwa nthawi yomweyo.

Amayi azaka zobereka ayenera kugwiritsa ntchito njira zodalirika zotetezera. Cholesterol, komanso zinthu zomwe zili ndi biosynthesis, zimagwira ntchito yofunika kwambiri pakukula kwa mwana wosabadwayo, motero, chiopsezo cholepheretsa kubwezeretsedwanso kwa HMG-CoA kumakulitsa phindu lochuluka pogwiritsa ntchito Tevastor.

Kafukufuku wokhudza chimbudzi cha rosuvastatin mkaka wa m'mawere sichinachitike, chifukwa chake ngati kuli koyenera kugwiritsa ntchito Tevastor panthawi yoyamwitsa, kuyamwitsa kuyenera kuyimitsidwa.

Mu vuto laimpso

Odwala omwe ali ndi matenda ofiira aimpso wofatsa kapena olimbitsa safuna kusintha kwa rosuvastatin. A kwambiri aimpso kulephera (CC

Maphunziro: Yoyamba University State Medical University yotchedwa I.M. Sechenov, wapadera "General Medicine".

Zambiri zokhudzana ndi mankhwalawa ndizofanana, zimaperekedwa pazidziwitso ndipo sizilowa m'malo mwa malangizo ovomerezeka. Kudzipatsa nokha mankhwala kuopsa!

Zoposa $ 500 miliyoni pachaka zimagwiritsidwa ntchito pa mankhwala azisamba okha ku United States. Kodi mukukhulupilirabe kuti njira yoti mugonjetse ziwengo ikapezeka?

Ku UK, kuli lamulo malinga ndi momwe dokotala wothandizira amatha kukanachita opaleshoni ngati atasuta kapena wonenepa kwambiri. Munthu ayenera kusiya zizolowezi zoipa, kenako, mwina, sangafunikire opareshoni.

Malinga ndi ziwerengero, Lolemba, chiopsezo cha kuvulala kwammbuyo chimawonjezeka ndi 25%, ndipo chiopsezo chogundidwa ndi mtima - ndi 33%. Samalani.

James Harrison wazaka 74 yemwe amakhala ku Australia amakhala wopereka magazi pafupifupi nthawi 1,000. Ali ndi mtundu wamagazi osafunikira, ma antibodies omwe amathandizira akhanda omwe ali ndi vuto lalikulu la magazi kupulumuka. Chifukwa chake, waku Australia adapulumutsa ana pafupifupi mamiliyoni awiri.

Poyamba zinkakhala kuti kumatheka kumapangitsa thupi kukhala ndi mpweya wabwino. Komabe, malingaliro awa adatsutsidwa. Asayansi atsimikizira kuti ukamadzuka, munthu amazizira ubongo ndikusintha magwiridwe ake.

Kuphatikiza pa anthu, cholengedwa chimodzi chokha padziko lapansi - agalu, omwe ali ndi vuto la prostatitis. Awa ndi abwenzi athu okhulupilika kwambiri.

Pali ma syndromes osangalatsa kwambiri azachipatala, monga kuphatikiza zinthu. M'mimba mwa wodwala m'modzi wodwala mania uyu, zinthu 2500 zakunja zidapezeka.

Pochezera pafupipafupi pakama pofufuta, mwayi wokhala ndi khansa yapakhungu umawonjezeka ndi 60%.

Madokotala a mano adapezeka posachedwa. Kalelo m'zaka za zana la 19, inali ntchito ya tsitsi wamba kuti akatulutse mano odwala.

Malinga ndi kafukufuku wa WHO, kuyankhulana kwa theka la ola limodzi pafoni kumawonjezera mwayi wokhala ndi chotupa muubongo ndi 40%.

Kuti tinene ngakhale mawu afupi komanso osavuta, timagwiritsa ntchito minofu 72.

Amayi ambiri amatha kusangalala mwakuganizira za thupi lawo lokongola pakalilore kuposa kugonana. Chifukwa chake, akazi, yesetsani kuyanjana.

Pogwira ntchito, ubongo wathu umagwiritsa ntchito mphamvu zambiri zofanana ndi babu la 10-watt. Chifukwa chake chithunzi cha babu wapamwamba pamutu panu panthawi yomwe chikuwoneka ngati chosangalatsa sichili kutali ndi chowonadi.

Munthu aliyense samangokhala ndi zala zapadera, komanso chilankhulo.

Chiwindi chanu chikasiya kugwira ntchito, imfa imatha pakatha tsiku limodzi.

Mafuta a nsomba akhala akudziwika kwazaka zambiri, ndipo munthawi imeneyi zatsimikiziridwa kuti zimathandizira kupewetsa kutupa, kuchepetsa ululu wolumikizana, kukonza sos.

Kodi mankhwalawa amagwira ntchito bwanji?

Mthupi la munthu aliyense pali mafuta apadera omwe amatha kukhala ndi vuto lenileni mthupi, amachepetsa zizindikiro zake zaumoyo.

Mafuta a cholesterol amakonda kukhazikika pazitseko zamitsempha yamagazi, mawonekedwe ang'onoang'ono, amathandizira kwambiri thanzi labwino la minyewa yonse, mitsempha ndi mitsempha, kuphatikizapo. Zonsezi zimabweretsa matenda osiyanasiyana, a ziwiya zokha komanso zamtima.

Madokotala amakono amapereka Tevastor kotero kuti mankhwalawa ali ndi phindu lapadera pachiwindi, pomwe zimachitika mwapadera chifukwa cha kuphwanya kwathunthu kwamafuta, ndiye kuti, chinthu chofunikira monga lipoproteins, chimachitika.

Zotsatira zoyambirira zoyenera za mankhwalawa zimatha kumveka patatha sabata limodzi kuchokera kumayambiriro koyambirira kwa mankhwalawa. Kutheka kwakukulu kumatha kupezeka ndikuwoneka pamwezi.

Kuti aphunzitse kuyendetsa bwino, maphunziro a magazi amapangidwa, omwe akuwonetsa kusintha kwa kuchuluka kwa ndende ya plasma yamitundu yonse ya lipoproteins.

Nthawi yomweyo, mankhwalawa amapereka zotsatira zabwino ndi kukanika kwa endothelium ya munthu, kusintha kwathunthu kwatsatanetsatane wamagulu a magazi, ndiko kuti, magazi amadzimadzi.

Chofunika kwambiri, mankhwalawa ndi abwino ngati antiproliferative ndi antioxidant. Nthawi yomweyo, mankhwala a pharmacokinetic otsatirawa akhoza kudziwika:

1. Tevastor, malangizo ogwiritsira ntchito omwe akumveka, amakhudzanso thupi, mosaganizira jenda ndi zaka.
2. Ndi mawonekedwe oopsa komanso otchulika a kulephera kwa chiwindi, kugwiritsidwa ntchito kwa mankhwala othandizira omwe ali m'magazi kumakhala kokwanira katatu kuposa masiku ena onse.
3. Zambiri za pharmacokinetics zimatengera mtundu komanso malo omwe odwala amakhala. Achi Japan ndi China ali ndi kuchuluka kuwirikiza kawiri, komwe sikumawonedwa pakati pa azungu.

Mulimonsemo, njira yochizira mankhwalawa imadziwika ndi kuchuluka kwa zotsatira zabwino komanso zovuta zochepa, kupatula kusalolera kwa munthu payekha.

Tulutsani mawonekedwe ndi malamulo oyambirira ovomerezeka

Tevastor, malangizo omwe ayenera kutsatiridwa pamankhwala, ndi mapiritsi othandizira omwe amapezeka ndimagulu osiyanasiyana a chinthu chachikulu, chomwe ndi rosuvastine. Iyenera kutengedwa pokhapokha potsatira malangizo a dokotala komanso malangizo a mankhwalawo.

Mwa zina mwa malamulo oyenera kumwa mankhwalawa amatha kusiyanitsidwa:

• Mankhwala amatengedwa mosasamala chakudya,
• Chithandizo chimayamba ndi mlingo wocheperako, pang'onopang'ono kuwonjezeranso pansi mosamala
• akatswiri
• Ngati ndi kotheka gwiritsani ntchito mankhwalawa ochulukirapo, wodwalayo amalandiranso chisamaliro chokwanira kwambiri.
• Asanayambe chithandizo, wodwalayo amalimbikitsidwa kuti adye zakudya zapadera za lipid. Iyenera kutsatira nthawi yonse ya chithandizo.

Zizindikiro zazikulu zogwiritsidwa ntchito

Mankhwalawa adapangidwira mavuto osiyanasiyana ogwirizana ndi hypertriglyceridemia. Chofunika kwambiri pa matenda a cholesterol yapamwamba.

Mankhwalawa angagwiritsidwe ntchito ngati chowonjezera pa zakudya zomwe zakudya ndi mafuta osachepera. Zotsatira zabwino zitha kupezeka pochiza matenda a atherosulinosis.

Izi ndizomwe ndizodziwika kwambiri pazamankhwala omwe madokotala amapereka Tevastor. Ubwino wa mankhwalawa ndi mwayi wogwiritsidwa ntchito ngati njira yothandiza kupewa matenda a mtima ndi mitsempha yamagazi.

Mwachitsanzo, mankhwalawa muyezo wocheperako amatha kumwa ndi amuna onse kuyambira azaka 55 ndipo amayi kuyambira wazaka 60. Kugwiritsa ntchito kwa prophylactic kwa mankhwalawa kumawonetsedwa kwa onse omwe amasuta komanso omwe ali ndi zovuta zina zathanzi.

Za mankhwala monga Tevastor, kuwunika kwa odwala kumatha kupezeka kuti ndizotheka.

Mitu ya mankhwalawa

Tevastor analogues, monga mankhwala ena onse. Zimapangidwa ndi opanga osiyanasiyana, ndichifukwa chake mayina ake, Mlingo, ndi kupezeka kwa zida zina zingakhale zosiyanasiyana.

Mankhwala osokoneza bongo amaphatikiza gulu la mankhwalawa, pomwe chofunikira kwambiri ndi rosuvastine.

Kukonzekera kwa gawoli kumadziwika ndi zofananira zomwe zimagwiritsidwa ntchito, contraindication, komanso amatha kuyambitsa zovuta zomwezo. Chida chotere, Tevastor, ma analogi a choloweza akhoza kukhala ndi izi:

Analogs, monga mankhwala enieniwo, ayenera kuikidwa ndi dokotala wokhazikika yemwe amachititsa mankhwalawo. Amaganizira zomwe zimachitika chifukwa cha matendawa, kusalolera kwake, komanso thanzi la wodwalayo, chifukwa mtengo wa mankhwalawo umatengera wopanga.

Mtengo wa Tevastor ndiwotchipa, mankhwalawa amagulitsidwa pa mtengo wokwanira ma ruble 220 piritsi limodzi ndi mlingo wa 5 mg, ndipo kwa Tevastor 20 mg mtengo umayikidwa pafupifupi 800 rubles.

Ndemanga za Tevastor

Za mankhwala ngati Tevastor, ndemanga pamaneti zitha kupezeka kuti zili ndi chiyembekezo. Odwala ali ndi kuchepa kwakukulu kwa cholesterol yayikulu m'magazi, kukonza bwino kwathunthu.

Za mankhwala a Tevastor ndemanga za madokotala amakhalanso ndi chiyembekezo. Nawa ochepa mwa iwo mwachitsanzo.

Zotsatira zoyipa ndi mankhwala osokoneza bongo a Tevastor

Tikulemba zakuphwanya kumene komwe kumakumana ndi mchitidwe wogwiritsa ntchito statin iyi nthawi zambiri (osachepera limodzi mwa zana) ndipo nthawi zambiri (munthawi imodzi mwa khumi).

Chifukwa chake, odwala nthawi zambiri amakhala ndi vuto la endocrine system, kuphatikizapo matenda a shuga. Komanso, kupweteka kwam'mutu, matenda am'mimba amawonedwa nthawi zambiri. Kuchokera ku minculoskeletal system, myositis, kupweteka kwa minofu, asthenia imatha kukhazikika.

Pafupifupi atatu mwa odwala zana omwe amagwiritsa ntchito muyezo wa mamiligalamu makumi anayi ali ndi mapuloteni mkodzo wawo.

Mankhwala osokoneza bongo a Tevastor amawonda ndi mawonekedwe a zovuta zina. Chithandizo chimayikidwa kutengera zizindikiro zake.

Amayi omwe adalembedwa kuti Tevastor ayenera kudziteteza mosamala kuti apewe kutenga pakati. Musanayambe maphunziro, muyenera kuchita mayeso okonzekera kutenga pakati. Ngati mimba idachitikabe, muyenera kusiya kugwiritsa ntchito mankhwalawa ndipo mukaonane ndi dokotala posachedwa.

Mapiritsi a Tevastor: malangizo ogwiritsira ntchito, analogi, mtengo ndi kuwunika

Tevastor ndi mankhwala omwe ali m'gulu la ma statins. Chofunikira chachikulu pa mankhwalawa ndi calcium wa rosuvastatin.

Mankhwala amachepetsa kuchuluka kwa magazi a chinthu monga kuperewera kachulukidwe lipoprotein. Nthawi yomweyo, pakumatenga kuchuluka kwa cholesterol m'magazi kumachepetsedwa kwambiri.

Tevastor wa mankhwala: malangizo ogwiritsira ntchito

Tevastor ndi gawo limodzi mwa gulu la mankhwala ochepetsa lipid.

Pa moyo wonse, mafuta oyipa amadziunjikira m'matumba ndi mawonekedwe amtundu. Izi zimabweretsa kutsekeka kwa magazi, atherosclerosis, kuperewera kwa mpweya wa minofu ya ziwalo, mtima.

Hypercholesterolemia (kukwezeka kwa cholesterol yamagazi) ndizotsogola kwa mtima ndi matenda amitsempha. Pofuna kupewa zoyipa, ndikofunikira kuti muchepetse kuchuluka kwamafuta oyipa.

Kugwiritsidwa ntchito kwa Tevastor kumathandizira kagayidwe kazakudya, ndikupewa matenda amtima.

Tevastor ndi gawo limodzi mwa gulu la mankhwala ochepetsa lipid.

Zotsatira za pharmacological

Chiwindi chimayambitsa kuthana ndi mafuta, kuphatikiza lipoproteins (LP) yoyipa. Mankhwala a hypolipidemic amachulukitsa kuchuluka kwa hepatic lowensens lipoprotein receptors (LDL), kumawonjezera kutsutsana ndi kukoka. Maphatikizidwe a lipoproteins ngakhale apansi amachepetsa. Izi zimabweretsa kuchepa kwa kuchuluka kwa cholesterol m'magazi.

Wogulitsa mankhwala ali ndi kusankha kosankha. Imachita mpikisano kuletsa 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase). Chifukwa cha izi, chiŵerengerocho chimachepetsedwa:

• cholesterol yathunthu yokhala ndi cholesterol yolumikizana kwambiri ndi lipoproteins (HDL),
• cholesterol yopanda HDL ndi cholesterol ya HDL
• Cholesterol yokhudzana ndi LDL ndi cholesterol yokhudzana ndi HDL,
• apolipoprotein A-1 ndi apolipoprotein B.

Mankhwalawa amatha kupatsidwa mitsempha ya varicose.

Kugwiritsa ntchito kwa Tevastor kumakhala ndi zotsatira zabwino osati kokha pamatumbo, komanso m'mitsempha. Mankhwalawa amatha kupatsidwa mitsempha ya varicose. Imasintha magazi, imathandizira kupereka okosijeni kuzinthu ndi ziwalo, kuyeretsa ndikulimbitsa makhoma amitsempha yamagazi ndi mitsempha.

Momwe mungatengere Tevastor

Musanayambe kumwa mankhwalawo komanso munthawi yonse ya chithandizo, muyenera kutsatira zakudya zomwe zimachepetsa lipid.

Izi zidzakulitsa mphamvu ya ntchito yogwira ndikuchotsa katundu wowonjezera pachiwindi.

Mlingo amasankhidwa ndi dokotala payekhapayekha. Kukhalapo kwa matenda osachiritsika ndi zomwe zimachitika mthupi zimaganiziridwa. Okwatirana okalamba zilibe kanthu.

Mlingo woyambirira ndi 5 mg. Piritsi imatengedwa pakamwa, kutsukidwa ndi madzi. Nthawi yatsiku ndi kudya kwambiri zilibe kanthu. Njira yocheperako yothandizira ndi masiku 7. Kuphatikiza zomwe zimachitika, mankhwalawa amatengedwa kwa mwezi umodzi kapena kuposerapo.

Ngati kuwunika koyendetsedwa pambuyo pa masabata anayi kumawonetsa zotsatira zoyipa, mlingo ungathe kuwonjezeka mpaka 10 kapena 20 mg patsiku. Mapiritsi a 40 mg amaperekedwa pokhapokha pakagwa mwadzidzidzi, chifukwa nthawi zambiri amayambitsa mavuto. Pankhaniyi, wodwala ayenera kuyang'aniridwa ndi dokotala.

Musanayambe kumwa mankhwalawo komanso munthawi yonse ya chithandizo, muyenera kutsatira zakudya zomwe zimachepetsa lipid.

Anthu omwe ali ndi vuto lofooka kapena locheperako amaloledwa kumwa Tevastor pamtundu uliwonse. Woopsa milandu, chithandizo ndi mankhwala wothandizidwayo tikulimbikitsidwa kuti tisiyane.

Dotolo amawona zabwino ndi zoopsa ku thanzi la wodwalayo, kenako amupereka chithandizo.

Kuchepa kwa chiwindi ndi chifukwa chomayang'anira wodwalayo akamamwa Tevastor. Hepatic insuffential imabweretsa kuledzera ndi rosuvastatin, amene kwa nthawi yayitali amazungulira limodzi ndi magazi mthupi lonse. Izi zimatha kusintha mkhalidwe wa impso ndikuwapangitsa kulephera.

Gwiritsani ntchito pa nthawi yoyembekezera

Cholesterol ndi yofunika kuti mwana akhazikike m'mimba mwa mayi. Wothandizila lipid-wotsitsa amakhudza kwambiri kamangidwe ka mwana wosabadwayo ndikukula kwa mwana. Chifukwa chake, munthawi yobereka mwana ndi kuyamwitsa, kutenga Tevastor ndizoletsedwa.

Cholesterol ndi yofunika kuti mwana akhazikike m'mimba mwa mayi.

Kuyanjana kwa mankhwala osokoneza bongo

Kulandila kwa Tevastor ndizoletsedwa nthawi imodzi ndi:

1. Cyclosporine. Ndi kulumikizana kwa mankhwalawa, kuchuluka kwa rosuvastatin kumawonjezeka ka 10. Izi zimatha kusintha chiwindi.
2. Gemfibrozil. Ngati mankhwalawa amatengedwa pamodzi ndi Tevastor, ndende ya yogwira imachulukitsa 2 times.
3. Mavitamini a Vitamini K. Kuphatikiza kwa mankhwalawa kumakhudza magazi. Tikutengedwa, nthawi yowundana imachulukanso, ikathetsedwa, imachuluka.
4. Kulera kwamlomo. Chithandizo chogwira chimakhudza kuchuluka kwa mahomoni.
5. Mankhwala othandizira omwe amalepheretsa proteinase. Kupanda kutero, mulingo wa rosuvastatin ukuwonjezeka kasanu.
6. Ma antacid othandizira othandizira. Aluminium ndi magnesium yomwe ilimo imachepetsa kuchuluka kwa yogwira ntchito nthawi 2.

Musanayambe chithandizo ndi othandizira kutsitsa kwa lipid, ndikofunikira kudziwitsa dokotala za mankhwala omwe amamwa nawonso. Izi zikuthandizani kusankha mlingo woyenera komanso kupewa mavuto.

Kutulutsa mawonekedwe ndi mankhwala

Tevastor - mapiritsi omwe amapangidwa mosiyanasiyana ndi magawo osiyanasiyana a yogwira - rosuvastatin. Tengani mogwirizana ndi malangizo, nthawi yoyenera odwala, ngakhale zakudya.

Amayamba kulandira chithandizo chamankhwala ochepa, kuwunika momwe wodwalayo alili mwezi woyamba. Ngati ndi kotheka, onjezani mlingo wa mankhwalawa. Popereka mankhwala okwanira, kuwunikira kwathunthu komanso mosamala kumachitika kwa wodwala.

Asanayambe chithandizo ndi Tevastor, wodwalayo amafunika kutsatira zakudya zomwe zimachepetsa lipid ndipo amakhala pamenepo kwa nthawi yonse ya mankhwalawa.

Mlingo wa mankhwala umasankhidwa payekha ndipo zimatengera zisonyezo.

Zotsatira zoyipa ndi bongo

Zotsatira zoyipa zomwe zingachitike mutamwa Tevastor nthawi zambiri zimakhala zofatsa ndipo nthawi zambiri zimakhala zokha. Pafupipafupi komanso kutha kwa zovuta zina ndi zomwe zimadziwika kuti zimadalira mlingo.

Timalemba zakuphwanya zomwe zingachitike tikamagwiritsa ntchito rosuvastatin nthawi zambiri (mlandu umodzi pa zana) ndipo nthawi zambiri (mlandu umodzi mwa khumi):

• zosokoneza pakugwira ntchito kwa endocrine system zimadziwika, nthawi zambiri zimakhala matenda a shuga,
• kupweteka kwa mutu kwa nthawi yayitali, chizungulire,
• matenda ammimba (nseru, kudzimbidwa, kupweteka kwa epigastric, kapamba),
• angioedema,
• proteinuria (zonyansa mu impso),
• mbali ya masculoskeletal system pali chiopsezo cha myositis, asthenia, kupweteka kwa minofu,
• mukamagwiritsa ntchito milingo 40 yamkodzo mumkodzo, mapuloteni amawonekera.

Maphunziro a Laborator adawona kuchuluka kwa bilirubin ndi glucose, ntchito ya GGT,

Mankhwala osokoneza bongo a Tevastor amawonda ndikuwonetsa zovuta, mankhwalawa omwe amaperekedwa malinga ndi zomwe akuwonetsa.

Yang'anani! Amayi omwe amatenga Tevastor amayenera kudziteteza mosamala kuti asatenge pathupi, ndipo pakakhala pakati, musasiye kumwa mankhwalawo ndikufunafuna upangiri wa dokotala mwachangu.

Tevastor: malangizo ogwiritsira ntchito, ndemanga ndi fanizo

Chiwerengero chachikulu cha anthu omwe ali okalamba amakumana ndi zovuta za metabolic, zomwe zimachitika chifukwa cha moyo wamunthu wamakono. Kuchepetsa kwa zochitika zolimbitsa thupi, kumwa mowa mwauchidakwa komanso kumwa mowa, kudya transgenic, masamba osaphika a masamba ochepa kumabweretsa kusintha kwa mbiri ya lipid komanso mtsogolo pakukula kwa atherosulinosis.

Kusintha kagayidwe ka mafuta m'thupi, kuwonjezera pakukhathamiritsa kwa magalimoto ndi zakudya, mankhwala amagwiritsidwa ntchito. Malinga ndi malangizo ogwiritsira ntchito mankhwala a Tevastor, ndi chida chomwe chimatsitsa cholesterol. Malinga ndi akatswiri ndi odwala, mtengo wa mankhwalawa umagwirizana ndi mtunduwo ndipo siwotsika pa analogues.

Zambiri pazokhudza Tevastor

Maphunziro ambiri azachipatala atsimikizira kuthekera kwa ma statins kuti achepetse chiopsezo chokhala ndi matenda amtima. Malinga ndi malingaliro apadziko lonse lapansi (mabungwe azachipembedzo a ku Europe ndi ku America aukadaulo wamtima), amawonetsedwa osati kwa anthu omwe ali ndi vuto la atherosclerosis ndi lipid mbiri, komanso magulu ena a anthu omwe ali ndi kuchuluka kwa cholesterol.

Ndikofunika kuperekera ma statins ngati muli ndi mbiri ya kugunda kwa mtima, sitiroko, kupindika kwa matenda a m'matumbo, matenda oopsa a shuga komanso kuphatikiza matenda oopsa, komanso kulephera kwambiri kwaimpso. Gulu la mankhwalawa limaphatikizapo Tevastor.

Gulu lazachipatala, INN, kuchuluka

Malinga ndi Anatomical ndi achire gulu la mankhwala, Tevastor ndi monocomponent lipid-kutsitsa mankhwala. Chidacho chikufanana ndi dzina ladziko lonse lapansi - rosuvastatin. Ndiwoyimira wa inhibitors wa enzyme HMG-CoA reductase ndi njira yosankha yochita ndipo ndi wa gulu la statins a m'badwo wachinayi.

Amagwiritsidwa ntchito kwambiri ndi akatswiri amtima wamtima kuti athetse kuchepa kwa vuto la mtima wamtima mwa anthu omwe ali ndi chiwopsezo chachikulu pamlingo wa SCore, komanso pochiza matenda a atherosulinosis.

Mitundu ya kumasulidwa ndi mitengo ya mankhwalawo, avareji ku Russia

Mtengo wa mankhwala a Tevastor mwachindunji zimatengera mlingo. Zavumbulutsanso kusinthasintha kwamitengo malinga ndi komwe kuli. Zogulitsa ndi phukusi la zidutswa 30 ndi 90. Mtengo womwe uli patebulopo ndi wa phukusi la matuza atatu okhala ndi mapiritsi khumi.

Calcium ya Rosuvastatin imagwira ntchito. Ndi gawo la blockers ya enzyme yomwe imayang'anira kapangidwe ka cholesterol - HMG-Coa-Reductase.

Wopangayo amagwiritsa ntchito lactose, microcrystalline cellulose, talc ngati filler. Kuti muwonjezere utoto, utoto umaphatikizidwa pakukonzekera - iron oxides achikasu ndi ofiira, azorubine. Amakhala otetezeka chifukwa chaumoyo ndipo amavomerezedwa kuti agwiritsidwe ntchito popanga mankhwala.

Mankhwala Okhala Pamalo a Pharmacy

Ngati muli ndi mankhwala kuchokera kwa dokotala.

Mtengo umatengera kuchuluka kwa mapiritsi omwe ali muphukusili ndi zomwe ali nazo pazomwe ali.

Mtengo wamba wa mapiritsi a 5 mg ndi ma ruble 400.Mankhwala okhala ndi 10 mg ya rosuvastatin amawononga ma ruble 470-500. Mapiritsi 20 mg - 600-700 ma ruble.

Ngati simungapeze mankhwala ofunikira a lipid ofunika, muthamangitse chidwi chake.

Zomwe zikuchitika ndi mankhwala a Tevastor ali pafupi ndi mankhwala monga:

• Atorvastatin
• Rosucard,
• Mertenil
• Roxer
• Akorta,
• Rustor
• Crestor
• Suvardio
• Rosulip,
• Rosicore
• Ro statin
• Razuvastatin,
• Rosart.

Musanalowe m'malo mankhwalawa, ndikulimbikitsidwa kuti mufunsane ndi dokotala. Dokotala aziganizira mawonekedwe a wodwala ndikusankha analogue yothandiza kwambiri.

Malamulo a kayendetsedwe koyenera ndi mlingo

Nthawi ya mankhwalawa iyenera kutsagana ndi chakudya chochepa m'mafuta a nyama komanso zopatsa mphamvu za m'mimba zingapo. Komanso, kuyanjana ndi mankhwala ena kuyenera kuganiziridwanso. Zodziwika bwino ndi kuphatikiza kwa rosuvastatin ndi cyclosporins, mavitamini a vitamini K, kuphatikiza kwapakati pakamwa, ndi erythromycin.

Nthawi zambiri, mlingo woyambira ndi 5 mg (piritsi 1/2 lomwe lili ndi 10 mg ya rosuvastatin). Piritsi imayenera kutengedwa pakamwa nthawi iliyonse masana. Kudya kulibe phindu lililonse pa pharmacokinetics ndi pharmacodynamics. Sikulimbikitsidwa kutafuna ndi kupera mankhwalawa.

Zofunika! Pambuyo pa milungu 4 yodyedwa pafupipafupi, mbiri ya lipid iyenera kubwerezedwa ndipo ngati kuli kotheka, kusintha kwa mankhwalawa kuyenera kupangidwa.

Zotheka zoyipa ndi bongo

Nthawi zambiri, chithandizo ndi Tevastor sichimabweretsa vuto labwino ndipo chimalekerera mosavuta. Komabe, mopanda chidwi ndi chimodzi mwazolemba zake, mulingo woyenera, komanso osagwirizana ndi malingaliro a mapiritsi, zotsatirazi zingakhale zotsatirazi:

• hepatitis poizoni, limodzi ndi jaundice ndi mayesero a chiwindi ntchito (thymol, AST, ALT, bilirubin okwanira), poizoni hepatitis
• kusokonekera kwa stool (kudzimbidwa, kutsekula m'mimba),
• thupi lawo siligwirizana, limodzi ndi redness pakhungu, kuyabwa, edincke, edema,
• Nthawi zina, kutsokomola, kupuma movutikira.
• chizungulire, maso osalala,
• kuphwanya kwa psycho-maikutlo thanzi (kugona, kusakwiya).

Ngati zizindikiro zomwe zili pamwambazi zikuchitika, muyenera kusiya kumwa mankhwalawo ndikuwonana ndi dokotala kuti ayang'anire ntchito ya impso ndi chiwindi.

Ndemanga pazakuyenda kwa Tevastor

Ndemanga zambiri kuchokera kwa odwala ndi madokotala zimathandizira kuwunika Tevastor.

Marina, wazaka 48: “Mwamwayi, poyesa kuchipatala, adapeza mafuta ambiri. Ndinali pachakudya kwa miyezi iwiri, palibe chomwe chinachitika. Cardiologist adalemba Tevastor mu theka la 10 mg piritsi. Zowona tsiku lililonse m'mawa. Patatha mwezi umodzi, cholesterol inatsika pang'ono. ”

Victor, wazaka 65: “Zaka ziwiri zapitazo adadwala matenda a mtima, adayamba kupimidwa bwino. Dotolo adayikira mapiritsi kuti achepetse cholesterol ngati choletsa kukonzanso. Ndikumva bwino, koma mwezi woyamba nditatha kumwa mankhwalawo ndidayamba kumva kupweteka.

Ndimamwa mapiritsiwa, mtengo wake umakhala wotsika mtengo, ndipo umakhala wabwino kwambiri, nseru wadutsa. ”Alexander, wazaka 43:“ M'banja lathu, patatha zaka 40, aliyense amakhala ndi mavuto okhudzana ndi cholesterol. Sindinachite chimodzimodzi. Tevastor adayikidwa, koma mankhwalawo sanandikwanira.

Nditangotenga chizungulire, ndinkafuna kugona. Dokotalayo akuti ndi woleza mtima - zimachitika nthawi zambiri, koma ndikuona kuti ndibwino kuuchotsa ngati mankhwalawo sanakwane nthawi yomweyo. ”

Golub Olga Vasilievna, katswiri wazaka 18: “Tevastor amagwiritsidwa ntchito kukonza matenda a lipid mwa anthu okulirapo kwa zaka 50 okhala ndi matenda oopsa. Nthawi zambiri mankhwalawa amaloledwa bwino, mankhwalawa amapezeka m'masitolo ambiri, mtengo umakhala wotsika mtengo.

Zotsatira zake sizimawonedwa nthawi yomweyo, koma zimakhalapo kwanthawi yayitali. Komabe, kuti mupeze chithandizo choyenera, ndikofunikira kusankha mlingo woyenera woganizira phindu ndi zoopsa zake. "

Mankhwala omwe ayambitsidwa panthawi yake ali ndi tanthauzo lotchuka kuphatikiza ndi moyo wabwino. Ma Statin sakhala mankhwala ovomerezeka pakupezeka kwa hypercholesterolemia, komabe, cholinga chawo ndichoyenera kuzindikira chiopsezo chokhala ndi matenda amtima.

Dziwani kuti Tevastor ndi mankhwala omwe amagwiritsidwa ntchito, ayenera kugwiritsidwa ntchito poyang'anira chiwindi ndi impso, komanso kuwunika pafupipafupi magazi.

Tikutsegula ... Katswiri wa Ntchito (Obstetrics and Gynecology)

• 2009 - 2014, Donetsk National Medical University. M. Gorky
• 2014 - 2017, Zaporizhzhya State Medical University (ZDMU)
• 2017 - pakadali pano, ndikupanga digiri yolembera matenda azachiphuphu

Yang'anani! Zambiri patsamba lamasamba zimatumizidwa ndicholinga chodziwa. Osadzisilira. Pazizindikiro zoyambirira za matendawa - funsani dokotala kuti akuthandizeni. Kodi muli ndi mafunso mutatha kuwerenga nkhaniyi? Kapena munaona cholakwika munkhaniyi, lembani kwa katswiri wa polojekiti.

Tevastor: malangizo ogwiritsira ntchito, analogi, mitengo ndi malingaliro

Kodi mapiritsi a Tevastor ndi chiyani, malangizo amomwe mungagwiritsire ntchito, ma analogu omwe alipo, mtengo wapakati, ndemanga za madokotala ndi odwala - chidziwitso chofunikira chomwe titha kudziwa pankhaniyi.

Mawonekedwe ndi kipimo

Tevastor wa mankhwala ndi wa gulu la mankhwala osankha zoletsa za HMG-CoA. Enzyme iyi imakhudzidwa ndi ma cholesterol opanga ma hepatocytes. Izi zimathandizira kupanga ma lipoproteins apamwamba kwambiri ndi ma cell a chiwindi.

Nthawi yomweyo, kuchuluka kwa cholesterol yoyipa kumachepa.

Chofunikira chachikulu cha Tevastor, rosuvastatin, chimakonza kuchuluka kwa cholesterol yonse, kuchepetsa ma triglycerides, komanso munthawi yomweyo kumachepetsa ma apolipoproteins B m'magazi ozungulira.

Tevastor imapezeka mu mawonekedwe a mapiritsi achikasu achikasu mu chipolopolo. Rosuvastatin angagulidwe pa mlingo wa 5, 10, 20 ndi 40 mg. Phukusi loyenera limakhala ndi mapiritsi 30 kapena 90, osindikizidwa ndi matuza a zidutswa 10. Dziko loyambira - Israeli.

Zotsatira zabwino za mankhwala omwe amapezeka ndi Tevastor nthawi zambiri zimawonedwa pambuyo pa masiku 7-10 ogwiritsidwa ntchito nthawi zonse. Kuchuluka kwa cholesterol okwera kumachitika pambuyo pa milungu inayi ya pharmacotherapy. Kusintha kwa koyamba kwa mlingo kuyenera kuchitika pamaziko a zokhala ndi mbiri ya lipid osati kale kuposa mwezi watatha mapiritsi.

Mlingo ndi makonzedwe

Tevastor imatha kutengedwa nthawi iliyonse yabwino kwa inu. Osaperera piritsi; imwani yonse ndi madzi kapena tiyi ofunda.

Kuperekera kwa mankhwala opangira mankhwala kuyenera kuphatikizidwa ndi menyu wazakudya ndi zolimbitsa thupi. Ndi dokotala wodziwa bwino yekha yemwe angasankhe mtundu woyenera wa mankhwalawa, poganizira zomwe zimachitika mthupi lanu komanso mbiri yakale ya zamankhwala.

Nthawi zambiri, mankhwalawa amayamba ndi kuyamba kwa 5-10 mg. Ngati patatha mwezi umodzi njira zochizira sizinapezeke, dokotala amasintha mlingo wa mankhwalawo.

Kuwunika bwino kwa regimen ya chithandizo kumachitika pogwiritsa ntchito kuyeserera kwa magazi kwa cholesterol ndi triglycerides.

Mlingo waukulu wa 40 mg umawonetsedwa kwa anthu omwe ali ndi vuto lalikulu la hypercholesterolemia komanso matenda amtima. Odwala otere amayang'aniridwa ndi achipatala kwamuyaya.

Pa mimba ndi mkaka wa m`mawere

Amayi onyamula mwana, ndikosayenera kugwiritsa ntchito mankhwala ochepetsa mphamvu ya lipid. Pa nthawi yoyembekezera, muyenera kupuma.

Kugwiritsa ntchito gulu la mankhwala ogulitsira amaloledwa pokhapokha pokhapokha ndikuyang'aniridwa mwamphamvu ndi achipatala.

Pankhani ya kuvuta kwamphamvu kugwiritsa ntchito ma statins panthawi yoyamwitsa, ndikofunikira kusamutsa mwana ku zakudya zopanda ntchito.

Popeza mphamvu yamankhwala pathupi la ana sinaphunziridwe bwino, mankhwalawa sagwiritsidwa ntchito ngati ana.

Kugwiritsa Ntchito

Malingaliro a madokotala ndi odwala ali ogwirizana - pali zotsatirapo zabwino kuchokera ku njira ya rosuvastatin. Madokotala amawona kusintha kwa ma cholesterol a labotale mkati mwa sabata ndi theka kuyambira chiyambi cha mankhwala. Nthawi yomweyo, ndizotheka kusintha ngati pakufunika kutero. Rosuvastatin ikugwirizana bwino ndi lingaliro la chithandizo chapamwamba kwambiri.

Odwala amawona kuti ndizotheka kudya kamodzi patsiku popanda kutengera kudya. Zotsatira zoyipa nthawi zambiri zimakhala zazing'ono komanso zakanthawi. Ena amadandaula za mtengo, makamaka pogula muyeso wokwanira. Koma nzika zambiri zomwe zidagwiritsa ntchito mankhwalawa zimakhutira ndi zotsatira za mankhwala ndikuletsa cholesterol yayikulu.

Ndemanga za Odwala

Lyudmila, wazaka 53, Moscow

Mtima unayamba kuvuta ndi zaka 47. Kupweteka kwakanthawi ndi kupsinjika kumatsitsidwa ndi moyo wabwinobwino ndi ntchito. Anatembenukira kwa wamtima wazaka, wopezeka ndi vuto la mtima. Dokotala adati atenge mapiritsi a Tevastor 10 mg kwa mwezi umodzi. Kafukufuku wobwereza adawonetsa zotsatira zabwino. Kuopsa kwa vuto la mtima kunachepa, kupsinjika kunabwezeretsa. Sindinazindikire mavuto aliwonse.

Elena, wazaka 59, Vladivostok

Ndinadwala mtima 3 zapitazo, anali ndi opareshoni ya mtima. Pofuna kuti izi zisachitike kachiwiri, adotolo adalembera Tevastor. Mankhwalawa amathandiza, koma mtengo. Pali ma analogu otsika mtengo.

Victor, wazaka 64, Rostov-on-Don

Ndakhala ndikusuta kuyambira ndili ndi zaka 21. Ndimakonda zakudya zamafuta ndi okazinga. Chifukwa cha izi, zovuta ndi zotengera zinayamba. Zotsatira zakuyesa magazi zinawonetsa cholesterol yokwera. Dokotala adalangiza mapiritsi a Tevastor monga kupewa atherosulinosis ndi kugunda kwa mtima. Ndimamwa mankhwalawa m'miyezi umodzi. Ndazindikira kuwongolera: mutu wanga sunachepera chizungu, sindimangodzikakamiza.

Panthawi yotenga Tevastor, kuchuluka kwa mapuloteni mumkodzo kumawonjezeka.

Madokotala amafufuza

Svetlana, wamtima wazaka 44, Astrakhan

Cholesterol wokwera amapezeka mwa onse okalamba komanso achinyamata. Pofuna kupewa mapangidwe a zolembera ndi ma pathologies owopsa, ndimapereka mankhwala ochepetsa lipid. Kuchiza ndi Tevastor kumapereka zotsatira zabwino pamwezi. Cholesterol yabwerera mwakale. Komabe, pofuna kupewa kuyambiranso, njira yoyendetsera uyenera kubwerezedwa nthawi ndi nthawi.

Anatoly, cardiologist, wazaka 39, Orenburg

Zizolowezi zoyipa, kusadya bwino, kusachita masewera olimbitsa thupi kumapangitsa kuti mafuta ayambe kukhazikika m'makoma amitsempha yamagazi. Ndikofunika kuzindikiritsa munthawi yake. Kuti athane ndi vutoli, ndimalimbikitsa mapiritsi a Tevastor kwa odwala. Amatsitsa cholesterol, koma kuyambiranso kumatha kuchitika ngati kuthetsedwa. Chifukwa chake, ndikofunikira kutsatira zakudya.

Mapiritsi a Tevastor: malangizo ogwiritsa ntchito ndi kuwunika kwa madokotala

Kutengera kuchuluka kwa mankhwalawa padziko lonse lapansi, malo oyamba okhala ndi malire ambiri amakhala ndi ma statins kuyambira pomwe anali ndi dzina lawolo.

Atorvastatin ndi mankhwala oyamba pa izi. Mankhwalawa adapangidwa mu August 1985 ku Germany.

Statin ndi mankhwala opangidwa kuti athane ndi hypercholesterolemia, ndi atherosulinosis yomwe ikubwera chifukwa chake. Zochita zawo ndikukonza maulalo a mbiri ya lipid, zithandizireni zotupa za mtima ndi kuchepetsa kutupa kwake.

Zokhudza ma statins pa cholesterol biosynthesis

Statins amachepetsa cholesterol yamagazi mwa kuphatikiza mu biosynthesis yake m'chiwindi.

Kuti mumvetsetse izi, ndikofunikira kutenga magawo onse kukhala magawo.

Pali zinthu zopitilira makumi awiri zomwe zimakhudzidwa ndi biosynthesis.

Posavuta pakuphunzira ndi kumvetsetsa, pali magawo anayi okha:

• gawo loyamba ndikukhazikika kwa glucose okwanira mu hepatocytes kuti ayambe kuchitapo kanthu, pambuyo pake enzyme HMG-CoA reductase iyamba kuphatikizidwa ndi njirayi, mchikakamizo cha gulu lomwe limatchedwa mevalonate limapangidwa ndi biotransfform,
• ndiye mevalonate wozunguliridwa amakhudzidwa ndi phosphorylation, imakhala mu kusamutsa kwamagulu a phosphorous ndi kugwidwa kwawo ndi adenosine tri-phosphate, kapangidwe kazinthu zamagetsi.
• gawo lotsatira - njira yoperekera - imakhala pakugwiritsa ntchito madzi pang'onopang'ono ndikusintha kwa mevalonate kukhala squalene, kenako kukhala lanosterol,
• kwa lanosterol, pakukhazikitsa ma bondage awiri, atomu ya kaboni imamangirizidwa - iyi ndi gawo lomaliza la cholesterol kupanga lomwe limapezeka mu organelle ya hepatocytes - endoplasmic reticulum.

Statin imakhudza gawo loyamba la kusinthika, kutsekereza enzyme HMG-CoA reductase ndipo pafupifupi kuyimitsa kwathunthu kupanga mevalonate. Njira imeneyi imakhala yodziwika kwa gulu lonse. Chifukwa chake zidapangidwa koyamba ndi asayansi aku Germany ku Pfizer m'zaka zapitazi.

Patatha zaka khumi mayesero azachipatala, ma statins adawonekera pamsika wamankhwala. Woyamba mwa iwo anali mankhwala oyamba Atorvastatin, ena onse adawonekera pambuyo pake ndipo ndi makope ake - awa ndi omwe amatchedwa ma generics.

Limagwirira ntchito mthupi

Tevastor ndi statin ya m'badwo wachinayi wokhala, monga chinthu chogwira ntchito, rosuvastatin. Tevastor ndi imodzi mwazinthu zotchuka kwambiri zaku Atorvastatin m'maiko a CIS - omwe adatsogola.

Pharmacodynamics ndi pharmacokinetics amafotokoza momwe Tevastor amachitikira pambuyo kulowa thupi la munthu.

Zolowera mkati mwa mucous membrane wam'mimba, chigawo chogwira ntchito chimatengedwa ndi magazi mthupi lonse ndikudziunjikira m'chiwindi pambuyo maola asanu.

Hafu ya moyo ndi maola makumi awiri, zomwe zikutanthauza kuti zimatenga pafupifupi maola makumi anayi kuti zitheke. Mankhwala amachotsedwa pamayendedwe achilengedwe - matumbo amachotsa 90%, ndalama zotsalazo zimatsitsidwa ndi impso.

Ndi kugwiritsa ntchito mankhwalawa pafupipafupi, chithandizo chokwanira kwambiri chimawonekera patatha mwezi umodzi chiyambi cha chithandizo.

Ngati wodwala ali ndi matenda osachiritsika, ma paracokinetic magawo amasintha:

1. Ndi kulephera kwambiri kwa aimpso, pomwe kupangika kwa creatine kumachepera 4 kapena kupitilira, kuchuluka kwa rosuvastatin kumawonjezeka nthawi 9. Odwala a hemodialysis, awa amawonjezeka mpaka 45%,
2. Kuchepa pang'ono komanso kwapakati kwaimpso, pomwe chivomerezo ndichiposa mamililita 30 pamphindi, kuchuluka kwa zinthu m'magazi kumatsalira pamlingo wowonjezera.
3. Ndi kulephera kwa chiwindi, kupatula kwa theka la moyo kumawonjezeka, ndiye kuti, zigawo zikuluzikulu zimapitilirabe kuzungulira magazi. Izi zimatha kuyambitsa kuledzera kwakukulu, kuwonongeka kwa impso, ndi poyizoni. Chifukwa chake, munthawi yamankhwala, ndikofunikira kutsatira mosamalitsa zomwe dokotala akukuuzani, kuti muchepetse bongo wambiri komanso munthawi yopititsa mayeso oyang'anira,

Mukamagwiritsa ntchito mankhwalawa, muyenera kukumbukira kuti mwa anthu amtundu waku Asia, kuchoka kwa rosuvastatin kumachedwetsedwa, kotero ayenera kuyikidwa mankhwala ochepera.

Malangizo ogwiritsira ntchito mankhwalawa

Pali mndandanda wazomwe mungagwiritse ntchito mankhwalawa.

Zizindikiro zonse zimawonetsedwa mu malangizo ogwiritsira ntchito.

Kuwongolera uku ndi gawo lofunikira pakukhazikitsa kwa mankhwala omwe agulitsidwa kudzera pa netiweki ya pharmacy.

Zizindikiro zazikulu pakugwiritsa ntchito mankhwalawa ndi:

1. Pulayimale (yokhala ndi lipoprotein yokha yotsika kwambiri yomwe imakwezedwa) ndi kusakanikirana (okwera ndi ma lipoprotein ochepa otsika kwambiri) hypercholesterolemia. Koma pokhapokha ngati kuwonjezeka kwa zochitika zolimbitsa thupi, kukana zizolowezi zoipa ndi chakudya chamagulu sizinabweretse zotsatira zomwe mukufuna,
2. Hypertriglycerinemia, pakumachulukitsa ochulukitsa lipoprotein, ngati zakudya zovuta sizinatsitse cholesterol,
3. Atherosulinosis - kuwonjezera kuchuluka kwa osachulukitsa lipoprotein zolandilira mu chiwindi kuti achepetse kuchuluka kwa cholesterol yoyipa,
4. Pofuna kupewa kukula kwa mtima wamavuto a atherosulinosis: pachimake infarction, ischemic stroke, angina pectoris, makamaka pamaso pangozi - kusuta, kuledzera, kunenepa kwambiri, zaka zopitilira 50.

Malangizo ogwiritsira ntchito amakhazikitsa mitundu yovomerezeka ya mankhwala.

Tengani pakamwa, kumwa madzi ambiri, ngakhale osadya, osafuna kutafuna kapena kuswa. Ndikulimbikitsidwa kumwa usiku, chifukwa masana mankhwalawa amathandizira, ndipo ambiri amachotsedwa m'thupi.

Mlingo woyambirira ndi 5 mg 1 nthawi patsiku. Mwezi uliwonse, ndikofunikira kuyang'aniridwa ndi lipid ndi kuonana ndi dokotala. Asanayambe chithandizo, dokotala wamtima amakakamizidwa kupereka chitsogozo chovomerezeka ndikufotokozera mavuto omwe ayenera kusiya kulandira ndi kupita kuchipatala.

Kuphatikiza apo, nthawi yonse ya mankhwalawa, ndikofunikira kutsatira zakudya za hypocholesterol, zomwe zikutanthauza kuti kuletsa kudya zamafuta, zakudya zokazinga, mazira, ufa ndi zakudya zotsekemera.

Zotsatira zoyipa za thupi

Zotsatira zoyipa zimagawidwa potengera ma pafupipafupi monga zimachitika pafupipafupi, osowa komanso osowa kwambiri.

Pafupipafupi - vuto limodzi mwa anthu zana - chizungulire, kupweteka m'makachisi ndi khosi, kukula kwa matenda a shuga 2, nseru, kusanza, kukhumudwa pang'onopang'ono, kupweteka kwa minofu, asthenic syndrome,

Osowerengeka - milandu imodzi pa anthu 1000 - zimachitika zonse zomwe zimagwiritsidwa ntchito ndi mankhwalawa kuchokera ku urticaria kupita ku edema ya Quincke, pancreatitis ya pachimake (kutupa kwa kapamba), zotupa pakhungu, myopathy,

Osowa kwambiri - 1/10000 milandu - rhabdomyolysis imachitika, uku ndikuwonongeka kwa minofu yam'mimba ndikutulutsidwa kwa mapuloteni owonongeka kulowa m'magazi ndikuchitika kwa kulephera kwa impso.

Zotsatira zosagwirizana ndi kugwiritsa ntchito mankhwalawa ndi izi:

• Mimba - Rosuvastatin ndi woopsa kwambiri kwa mwana wosabadwayo chifukwa, poletsa kapangidwe ka cholesterol, chimasokoneza mapangidwe a khoma la cell. Izi, zimabweretsa kukula kwa intrauterine, kufooka kwa ziwalo zambiri, komanso kupuma. Mwana wosabadwayo amatha kufa kapena kubadwa ndi vuto lalikulu, motero, ndikulimbikitsidwa kuti mankhwala ena apatsidwe kwa wodwala yemwe ali ndi pakati.
• Kuyamwitsa - izi sizinayesedwe m'maphunziro azachipatala, chifukwa chake zoopsa zake sizinachitike. Pakadali pano, mankhwalawa ayenera kusiyidwa.
• Ana ndi achinyamata chifukwa cha kupanda ungwiro kwa maphunzirowa atha kusokonezeka, motero, kuvomerezedwa kwa zaka 18 ndizoletsedwa.
• Kulephera kwakukulu kwaimpso.
• Matenda a chiwindi, pachimake kapena aakulu.
• Mukalamba, ndikofunikira kupereka mankhwala mosamala. Kuyamba kwa 5 mg, osapitirira 20 mg pa tsiku motsogozedwa ndi achipatala.
• Pambuyo kupatsidwa ziwalo chifukwa cha kulephera kwa cyclosporine, komwe kumachepetsa kukana komwe kumachitika ndi rosuvastatin.
• Pamodzi ndi anticoagulants, popeza Tevastor amawonjezera zochita zawo, akuwonjezera nthawi ya prothrombin. Izi zitha kupsa ndi magazi ochokera mkati.
• Simungathe kuzitenga ndi mankhwala ena a statins ndi hypocholesterolemic chifukwa cha kuphatikiza kwa pharmacokinetics.
• Lactose tsankho.

Kuphatikiza apo, ndizoletsedwa kumwa mankhwala ngati wodwala ali ndi vuto la hypersensitivity pazinthu zilizonse za mankhwala.

Zambiri zokhudzana ndi ma statins zimaperekedwa kanema munkhaniyi.

Sonyezani shuga yanu kapena sankhani jenda kuti muyiyikire.