Amoxiclav kuyimitsidwa kwa ana ndi akulu

Ufa pakukonzekera kuyimitsidwa kwa makonzedwe amkamwa kuyambira oyera mpaka oyera achikasu, kuyimitsidwa kokhazikika sikupangika, kuyambira pafupifupi kuyera mpaka chikaso.

Othandizira: anhydrous citric acid, anhydrous sodium citrate, sodium benzoate, microcrystalline cellulose, sodium carmellose, xanthan chingamu, colloidal silicon dioxide, silicon dioxide, sodium saccharase, mannitol, flavorings (sitiroberi, chitumbuwa chakuthengo, mandimu).

25 g - mabotolo a galasi lakuda ndi voliyumu ya 100 ml (1) yathunthu ndi supuni / pipette - mapaketi a makatoni.

Ufa pakukonzekera kuyimitsidwa kwa makonzedwe amkamwa kuyambira oyera mpaka oyera achikasu, kuyimitsidwa kokhazikika sikupangika, kuyambira pafupifupi kuyera mpaka chikaso.

Othandizira: anhydrous citric acid, anhydrous sodium citrate, sodium benzoate, microcrystalline cellulose, sodium carmellose, xanthan chingamu, colloidal silicon dioxide, silicon dioxide, sodium saccharase, mannitol, flavorings (sitiroberi, chitumbuwa chakuthengo, mandimu).

25 g - mabotolo a galasi lakuda ndi voliyumu ya 100 ml (1) yathunthu ndi supuni / pipette - mapaketi a makatoni.

Ufa pakukonzekera kuyimitsidwa kwa makonzedwe amkamwa kuyambira oyera mpaka oyera achikasu, kuyimitsidwa kokhazikika sikupangika, kuyambira pafupifupi kuyera mpaka chikaso.

Othandizira: anhydrous citric acid, anhydrous sodium citrate, microcrystalline cellulose, carmellose sodium, xanthan chingamu, colloidal silicon dioxide, silicon dioxide, sodium saccharin, mannitol, flavorings (sitiroberi, chitumbuwa chamtchire, ndimu).

8,75 g - 35 ml mabotolo amdima amdima (1) athunthu ndi pipette ya dosing - mapaketi okhala ndi makatoni.
12,5 g - mabotolo agalasi wakuda ndi voliyumu ya 50 ml (1) yathunthu ndi pipette ya dosing - mapaketi a makatoni.
17,5 g - mabotolo amdima amdima okhala ndi voliyumu 70 ml (1) okwanira ndi piritsi ya dosing - mapaketi okhala ndi makatoni.
35 g - 140 ml mabotolo amdima amdima (1) athunthu ndi pipette ya dosing - mapaketi okhala ndi makatoni.

Zotsatira za pharmacological

Amoxiclav ® ndi kuphatikiza kwa amoxicillin - semisynthetic penicillin wokhala ndi zochita zambiri za antibacterial ndi clavulanic acid - choletsa chosasintha cha β-lactamases. Clavulanic acid imakhala yovuta kukhazikika nayo michere iyi ndikuwonetsetsa kukana kwa amoxicillin pazotsatira za β-lactamases zopangidwa ndi tizilombo.

Clavulanic acid, yofanana ndi mankhwala a beta-lactam, ali ndi mphamvu yofooka ya antibacterial.

Amoxiclav ® ili ndi mawonekedwe osiyanasiyana a antibacterial action.

Imagwira ntchito pothana ndi zovuta zomwe zimakhudzidwa ndi amoxicillin, kuphatikiza mitundu yopangika ya β-lactamases, incl. Bacteria-aerobic bacteria: Streptococcus pneumoniae, Streptococcus pyogene, Streptococcus viridans, Streptococcus bovis, Staphylococcus aureus (kupatula ma methicillin osagwirizana ndi methicillin, staphylococcus epermidis (kupatula methicillin -cycuscuscuscuscuscuscuscuscusocus, grasocus, cycococcincycycus, cycococcincycycus, cycosocus, cycosocus, cycococscus, cycosocus, cycococepticus. : Bordetella pertussis, Brucella spp., Campylobacter jejuni, Escherichia coli, Gardnerella vaginalis, Haemophilus influenzae, Haemophilus ducreyi, Klebsiella spp., Moraxella catarrhalis spp. , Vibrio cholerae, Yersinia enterocolitica, Helicobacter pylori, Eikenella corrodens, anaerobic gram-bacteria bacteria: Peptococcus spp., Peptostreptococcus spp. Clostridium spp., Actinomyces israelii, Fusobacterium spp., Prevotella spp., Gram-hasan anaerobes: Bacteroides spp.

Pharmacokinetics

Magawo akuluakulu a pharmacokinetic a amoxicillin ndi clavulanic acid ndi ofanana.

Zonsezi zimapangidwa bwino mutatha kumwa mankhwalawo mkati, kudya sikumakhudza kuchuluka kwa mayamwidwe. C max mu plasma imatheka ola limodzi pambuyo pa kukhazikitsa. Miyezo ya C max ya amoxicillin (kutengera mlingo) ndi 3-12 μg / ml, wa clavulanic acid - pafupifupi 2 μg / ml.

Zonsezi zimadziwika ndi kuchuluka kogawika m'madzi amthupi ndi minyewa (mapapu, khutu lapakati, zotulutsa ndi zotumphukira za chiberekero, chiberekero, mazira, ndi zina). Amoxicillin imalowanso madzi ophatikizika a chiwindi, chiwindi, matumbo a prostate, minofu ya palatine, minofu ya minyewa, chikhodzodzo, kutsekeka kwa mphuno, malovu, kubisala kwa bronchial.

Amoxicillin ndi clavulanic acid simalowa BBB ndi mauna osavulala.

Amoxicillin ndi clavulanic acid amawoloka zochuluka zotchinga ndipo mumayang'anira kuchuluka amatsitsidwa mkaka wa m'mawere. Amoxicillin ndi clavulanic acid amadziwika ndi zomanga zochepa m'mapuloteni a plasma.

Amoxicillin amaphatikizidwa pang'ono, asidi clavulanic mwachidziwikire amatha kuyamwa kwambiri.

Amoxicillin amachotseredwa ndi impso pafupifupi osasinthika ndi kubisala kwa tubular ndi kusefera kwa glomerular. Clavulanic acid imapukusidwa ndi kusefera kwa glomerular, mwanjira ina ya metabolites. Zing'onozing'ono zimatha kupukusidwa kudzera m'matumbo ndi m'mapapu. T 1/2 ya amoxicillin ndi clavulanic acid ndi maola 1-1,5.

Pharmacokinetics mu milandu yapadera yamankhwala

Kulephera kwakukulu kwa aimpso, T 1/2 imawonjezeka mpaka maola 7.5 a amoxicillin ndi maola 4.5 a clavulanic acid. Zonsezi zimachotsedwa ndi hemodialysis ndi zochepa zazing'ono ndi peritoneal dialysis.

Zizindikiro Amoxiclav ®

Matenda oyambitsidwa ndi tizilombo tating'onoting'ono tating'ono:

• matenda a chapamwamba kupuma thirakiti ndi ENT ziwalo (kuphatikizapo pachimake ndi matenda sinusitis, pachimake ndi matenda otitis TV, pharyngeal abscess, tonsillitis, pharyngitis),
• matenda am'munsi kupuma thirakiti (kuphatikizapo pachimake bronchitis ndi bakiteriya wamphamvu, matenda opha ziwalo, chibayo),
• matenda a kwamkodzo thirakiti
• matenda azamatenda
• matenda a pakhungu ndi minofu yofewa, kuphatikiza kulumidwa kwanyama ndi anthu,
• matenda a mafupa ndi osakanikirana,
• matenda am'mimba thirakiti (cholecystitis, cholangitis),
• matenda odontogenic.

Mlingo

Mlingo watsiku ndi tsiku wa kuyimitsidwa 125 mg + 31.25 mg / 5 ml ndi 250 mg + 62,5 mg / 5 ml (kuti muthandizire kudziwa kuyimitsidwa koyenera, phukusi lililonse la mankhwalawa lili ndi 125 mg + 31.25 mg / 5 ml ndi 250 mg + 62,5 mg / 5 ml ndi mphamvu 5 ml kapena pipette womaliza maphunziro.

Makanda obadwa kumene ndi ana opitilira miyezi itatu amafunsidwa 30 mg / kg (kwa amoxicillin) / tsiku, logawidwa mu 2 Mlingo uliwonse (maola 12 aliwonse), kwa ana opitilira miyezi itatu - kuyambira 20 mg (kwa amoxicillin) / kg / tsiku la matenda ofatsa komanso odziletsa kuopsa kwa maphunzirowa mpaka 40 mg / kg (malinga ndi amoxicillin) / tsiku la matenda oopsa ndi matenda amtundu wa kupuma, omwe amagawidwa m'magawo atatu (maola 8 aliwonse).

Mlingo wolimbikitsidwa malinga ndi kuchuluka kwa thupi la mwanayo komanso kuopsa kwa matendawa.

Mlingo watsiku ndi tsiku wa kuyimitsidwa kwa 400 mg + 57 mg / 5 ml amawerengedwa pa kilogalamu imodzi ya kulemera kwa thupi malinga ndi kuopsa kwa matendawa ndipo 25 255 mg / kg thupi / tsiku (malinga ndi amoxicillin), wogawidwa mu 2 waukulu.

Kuwongolera dosing yoyenera, kuyimitsidwa kwa 400 mg + 57 mg / 5 ml ndikuyikidwa mu phukusi lirilonse la pipette ya mlingo, omaliza nthawi imodzi mu 1, 2, 3, 4, 5 ml ndi magawo 4 ofanana.

Mlingo wovomerezeka woyenera kutengera thupi la mwana komanso kuopsa kwa matendawa.

Mlingo wofanana watsiku ndi tsiku amawerengedwa potengera thupi la mwana, osati zaka zake.

Mlingo wapamwamba wa tsiku ndi tsiku wa amoxicillin ndi 6 ga kwa akulu, 45 mg / kg pa thupi la ana.

Mlingo wapamwamba wa tsiku ndi tsiku wa clavulanic acid (munthawi ya mchere wa potaziyamu) ndi 600 mg kwa akulu ndi 10 mg / kg yolemetsa wa ana.

Odwala omwe ali ndi vuto lalikulu la impso (CC osakwana 10 ml / min), mlingo uyenera kuchepetsedwa mokwanira kapena pakati pakati Mlingo wachiwiri uyenera kuchuluka (ndi anuria mpaka maola 48 kapena kupitilira).

Njira ya mankhwala ndi masiku 5-14. Kutalika kwa nthawi ya chithandizo akutsimikiza ndi dokotala. Kuchiza sikuyenera kupitirira masiku opitilira 14 popanda kupimidwa kachiwiri.

Malamulo pokonzekera kuyimitsidwa

Ufa pakukonzekera kuyimitsidwa kwa 125 mg + 31.25 mg / 5 ml: gwedezani botolo mwamphamvu, onjezerani madzi a 86 ml (pamalowo) mu milingo iwiri, nthawi iliyonse kugwedezeka bwino mpaka ufa utasungunuka kwathunthu.

Ufa pakukonzekera kuyimitsidwa kwa 250 mg + 62,5 mg / 5 ml: gwedezani botolo mwamphamvu, onjezerani 85 ml ya madzi (mpaka chizindikiro) mumiyeso iwiri, nthawi iliyonse kugwedezeka bwino mpaka ufa utasungunuka kwathunthu.

Ufa pakukonzekera kuyimitsidwa kwa 400 mg + 57 mg / 5 ml: gwiritsani ntchito vial mwamphamvu, onjezerani madzi pazowonetsedwa pa cholembedwa ndikuwonetsedwa patebulopo (mpaka chizindikiro) mumiyeso iwiri, nthawi iliyonse kugwedezeka bwino mpaka ufa utatha.

Musanagwiritse ntchito, vial ayenera kugwedezeka mwamphamvu.

Zotsatira zoyipa

Zotsatira zoyipa nthawi zambiri zimakhala zofatsa komanso zosakhalitsa.

Kuchokera pamatumbo: kuperewera kwa chakudya, kusanza, kusanza, kupweteka m'mimba, kuwonongeka kwa chiwindi, kuwonjezeka kwa michere ya chiwindi (ALT kapena AST), kawirikawiri - cholestatic jaundice, hepatitis, pseudomembranous colitis.

Thupi lawo siligwirizana: kuyabwa, urticaria, erythematous zidzolo, kawirikawiri - multiforme exudative erythema, angioedema, anaphylactic mantha, matupi a vasculitis, kawirikawiri - exfoliative dermatitis, Stevens-Johnson syndrome, pachimake chachikulu pantulosis.

Kuchokera pa hemopoietic dongosolo ndi dongosolo la lymphatic: kawirikawiri - kusinthika kwa leukopenia (kuphatikizapo neutropenia), thrombocytopenia, kawirikawiri - hemolytic anemia, kuchuluka kosinthika kwa prothrombin nthawi (ikaphatikizidwa ndi anticoagulants), eosinophilia, pancytopenia.

Kuchokera wamanjenje: chizungulire, kupweteka mutu, kawirikawiri - kukomoka (kumachitika mwa odwala omwe ali ndi vuto laimpso akamamwa mankhwalawa kwambiri), kuchepa mtima, nkhawa, kusowa tulo.

Kuchokera kwamikodzo dongosolo: kawirikawiri - interstitial nephritis, crystalluria.

Zina: kawirikawiri - kukulitsa kwa superinfection (kuphatikiza candidiasis).

Contraindication

• Hypersensitivity ku zilizonse za mankhwala,
• Hypersensitivity m'mbiri mpaka penicillin, cephalosporins ndi mankhwala ena a beta-lactam,
• mbiri ya umboni wa cholestatic jaundice komanso / kapena chiwindi china chovulala chifukwa chotenga amoxicillin / clavulanic acid,
• matenda mononucleosis ndi lymphocytic leukemia.

Mochenjera, muyenera kugwiritsa ntchito mankhwalawa ndi mbiri ya pseudomembranous colitis, ndi vuto la chiwindi, kuwonongeka kwambiri kwaimpso, komanso panthawi ya mkaka wa m`mawere.

Malangizo apadera

Ndi njira ya chithandizo, ntchito za magazi, chiwindi ndi impso ziyenera kuyang'aniridwa.

Odwala kwambiri mkhutu aimpso ntchito, kukonzekera koyenera wa dosing regimen kapena kuwonjezeka kwa pakati pakati pa dosing kumafunika.

Pofuna kuchepetsa chiopsezo cha zovuta kuchokera m'matumbo am'mimba, mankhwalawa amayenera kumwa ndi zakudya.

Mayeso a Laborator: kuchuluka kwa amoxicillin kumapereka mayankho olakwika a mkodzo akamagwiritsa ntchito njira ya Benedict kapena Reelling's. Enzymatic zimachitikira ndi glucosidase tikulimbikitsidwa.

Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu

Palibe deta pazovuta za Amoxiclav mu Mlingo wolimbikitsidwa pakuyendetsa galimoto kapena kugwira ntchito ndi makina.

Bongo

Palibe malipoti a imfa kapena zovuta zoyipa chifukwa cha mankhwala osokoneza bongo.

Zizindikiro: Nthawi zambiri, kusokonezeka kwa m'mimba thirakiti (kupweteka kwam'mimba, kutsegula m'mimba, kusanza), kuda nkhawa, kugona tulo, chizungulire ndizotheka.

Chithandizo: wodwalayo ayenera kuyang'aniridwa ndi achipatala, monga mankhwala. Pankhani ya mankhwalawa posachedwa a mankhwalawa (osachepera maola 4), ndikofunikira kutsuka m'mimba ndikuwapatsa makala ophatikizidwa kuti muchepetse mayamwa. Amoxicillin / potaziyamu clavunate amachotsedwa ndi hemodialysis.

Amoxiclav kuyimitsidwa - malangizo ntchito

Mankhwala abwino kwambiri a mankhwalawo adamupatsa mbiri ngati njira yodalirika yolimbana ndi matenda ambiri. Amoxiclav amalimbikitsidwa ndi madokotala otsogolera ku Russia ndi mayiko ena a CIS. Komabe, ngati agwiritsidwa ntchito molakwika, mankhwalawa amatha kuvulaza thupi la munthu. Kuti mupewe zolakwika zotere, musanayambe chithandizo, werengani malangizowo mwatsatanetsatane ndikuyang'ana kwa dokotala.

Yogwira pophika mankhwala, kupereka antibacterial zotsatira - amoxicillin ndi clavulanic acid. Izi zimalepheretsa kukula ndi kubereka kwa zinthu zoyipa.Kuphatikiza pa iwo, kapangidwe kake kamakhala ndi zinthu zina zothandiza zomwe zimapangitsa kuti mankhwalawo amvedwe ndi thupi la munthu:

• anhydrous citric acid,
• carmellose sodium
• colloidal silicon dioxide,
• sodium saccharin
• sodium citrate,
• cellcrystalline mapadi,
• xanthan chingamu,
• sodium benzoate
• silika
• mannitol
• kukoma (mandimu, sitiroberi, chitumbuwa).

Pharmacodynamics ndi pharmacokinetics

Mankhwala amagwiritsidwa ntchito polimbana ndi tizilombo tating'onoting'ono tambiri:

• aerobic gram zabwino ndi gram alibe mabakiteriya,
• anaerobic gram zabwino komanso gram alibe mabakiteriya,
• mitundu ya beta-lactamase II, III, IV, V (maumboni amtunduwu omwe amalimbana ndi amoxicillin amawonongeka bwino ndi chinthu chachiwiri chogwira - clavulanic acid).

Mutatenga kuyimitsidwa mkati, zigawo za Amoxiclav zimatengedwa mwachangu ndi ziwalo za m'mimba za m'mimba. Kugwiritsa ntchito nthawi yomweyo sikuti kumathandiza kuti muchepetse kuyamwa, chifukwa chake palibe chifukwa chofunikira kupumira musanadye. Nthawi yoti mufikire pazambiri za clavulanic acid ndi amoxicillin pafupifupi mphindi 45. Kutengera mlingo womwe dokotala wakhazikitsa, chithandizo sichimapweteka thupi. Zinthu zophulika za Amoxicillin zimachotsedwa m'thupi mkati mwa masiku 10-15.

Gulu la Nosological (ICD-10)

Zizindikiro zogwiritsidwa ntchito

Amoxiclav ufa tikulimbikitsidwa milandu ngati kuli koyenera kulimbana ndi matenda oyambitsidwa ndi tizilombo tating'onoting'ono tovuta tating'ono. Izi zikuphatikiza:

• matenda a chapamwamba kupuma thirakiti ndi ENT ziwalo (aakulu ndi pachimake sinusitis, pharyngeal abscess, pharyngitis, tonsillitis, otitis media),
• matenda opatsirana a m'munsi kupuma thirakiti (pachimake mawonekedwe a bronchitis ndi gawo la bakiteriya wamphamvu, chibayo, etc.),
• matenda azamatenda
• matenda a kwamkodzo thirakiti
• matenda a pakhungu ndi minofu yolumikizana,
• minofu yofewa ndi khungu (kuphatikizapo kuluma kwa anthu ndi nyama),
• matenda odontogenic
• matenda ammimba thirakiti (cholangitis, cholecystitis).

Kufotokozera za mtundu wa kipimo

Mapiritsi 250 + 125 mg: yoyera kapena pafupifupi yoyera, ya oblong, ya octagonal, ya biconvex, yojambula yokutidwa, yokhala ndi "250/125" mbali imodzi ndi "AMC" mbali inayo.

500 + 125 mg mapiritsi: oyera kapena pafupifupi oyera, chowulungika, biconvex, wokutidwa ndi filimu.

Mapiritsi 875 + 125 mg: yoyera kapena pafupifupi yoyera, yofupika, ya biconvex, yokhala ndi makanema, yopezeka ndi zikwangwani ndi kutanthauza "875" ndi "125" mbali ina ndi "AMC" mbali inayo.

Onani pa kink: misa yachikasu.

Mphamvu yakuyimitsidwa pakamwa: ufa kuchokera kuzoyera mpaka zoyera zachikasu. Kuyimitsidwa koyimitsidwa ndikuyimitsidwa kopusa kuchokera pafupifupi koyera mpaka chikasu.

Ufa pakukonzekera njira yothetsera utsogoleri wa iv: kuyambira oyera mpaka oyera achikasu.

Mapiritsi omwaza: oblong, octagonal, wachikasu wopepuka komanso wowerengeka wa bulauni, wokhala ndi fungo labwino.

Mimba komanso kuyamwa

Pa nthawi yobereka komanso mkaka wa m'mawere, Amoxiclav ® imagwiritsidwa ntchito pokhapokha ngati phindu lomwe likuyembekezeredwa kuti lipite kwa mayi limaposa chiwopsezo cha mwana wosabadwayo ndi mwana.

Amoxiclav ® Quicktab imatha kulembedwera panthawi yapakati ngati pali mawonekedwe omveka.

Amoxicillin ndi clavulanic acid ochepa omwe amalowa mkaka wa m'mawere.

Zotsatira zoyipa

Mapiritsi okhala ndi mafilimu a Amoxiclav ® ndi ufa wokonzekera yankho la iv

Kuchokera m'mimba: kusowa chilimbikitso, kusanza, kusanza, kutsegula m'mimba, kupweteka kwam'mimba, gastritis, stomatitis, glossitis, lilime "lakuda", kuyimitsidwa kwa mano enamel, hemorrhagic colitis (ingathenso kuyamba pambuyo pa mankhwala), enterocolitis, pseudomembranous colitis, kuwonongeka kwa chiwindi, ntchito ALT, AST, zamchere phosphatase ndi / kapena plasma bilirubin, kulephera kwa chiwindi (pafupipafupi kwa okalamba, amuna, omwe ali ndi chithandizo chambiri), cholestatic jaundice, hepatitis.

Zotsatira zoyipa: pruritus, urticaria, erythematous totupa, erythema multiforme exudative, angioedema, anaphylactic mantha, matupi a vasculitis, exfoliative dermatitis, Stevens-Johnson syndrome, pachimake chachikulu pantulosis, matenda ofanana ndi seramu matenda, poizoni epermus.

Kuchokera ku hemopoietic dongosolo ndi dongosolo la lymphatic: leukopenia yosinthika (kuphatikizapo neutropenia), thrombocytopenia, hemolytic anemia, kuchuluka kosintha kwa PV (akagwiritsidwa ntchito limodzi ndi anticoagulants), kuchuluka kosintha kwa nthawi yotaya magazi, eosinophilia, pancytopenia, thrombocytosis, agranulocytosis.

Kuchokera kumbali yamanjenje yapakati: chizungulire, kupweteka mutu, kukomoka (kumachitika mwa odwala omwe ali ndi vuto laimpso akamamwa kwambiri.

Kuchokera pamikodzo: interstitial nephritis, crystalluria, hematuria.

Zina: candidiasis ndi mitundu ina yamphamvu kwambiri.

Mapiritsi okhala ndi filimu, ufa wotseka pakamwa, ufa wowonjezera pakamwa kuwonjezera

Kuchokera kumbali yamanjenje yapakati: Hyperacaction. Kumva nkhawa, kusowa tulo, kusintha kwa machitidwe, kukondwerera.

Amoxiclav ® Quicktab ndi Amoxiclav ® ufa kuyimitsidwa pakamwa

Kuchokera ku ziwalo za hemopoietic ndi dongosolo la lymphatic: osowa - leukopenia yosinthika (kuphatikizapo neutropenia), thrombocytopenia, kawirikawiri - eosinophilia, thrombocytosis, agranulocytosis, kuchuluka kwa magazi ndi kuchuluka kwa PV, kuchepa magazi, kuphatikiza magazi kusinthanso hemolytic magazi m'thupi.

Kuchokera ku chitetezo chamthupi: pafupipafupi sizikudziwika - angioedema, anaphylactic zimachitika, matupi awo saviyo, ndi matenda ofanana ndi seramu.

Kuchokera ku dongosolo lamanjenje: pafupipafupi - chizungulire, kupweteka mutu, kawirikawiri - kusowa tulo, kusokonezeka, nkhawa, kusintha kwa machitidwe, kusinthika kwa mankhwalawa, kupweteka, kupweteka kumachitika mwa odwala omwe ali ndi vuto laimpso, komanso kwa iwo omwe amalandira kuchuluka kwa mankhwalawa.

Kuchokera m'mimba: Nthawi zambiri - kusowa kwa chakudya, nseru, kusanza, kutsekula m'mimba. Khansa ya msana imawonedwa kwambiri tikamamwa mitundu yayikulu. Ngati matenda am'mimba atatsimikiziridwa, amatha kutha ngati mankhwalawo atengedwa kumayambiriro kwa chakudya, osagaya chakudya, osachedwa kugaya mankhwala omwe amayamba chifukwa cha ma antibayotiki (kuphatikizapo pseudomembranous ndi hemorrhagic colitis), lilime la "tsitsi" lakuda, gastritis stomatitis. Mu ana, kusintha kwa mawonekedwe a mawonekedwe a mano enamel sikunachitike kawirikawiri. Kusamalira pakamwa kumathandiza kupewa kubowola kwa enamel ya dzino.

Pa khungu: pafupipafupi - zotupa pakhungu, kuyabwa, urticaria, kawirikawiri - kuchuluka kwa erythema kosadziwika, kusadziwika kwapafupipafupi - Stevens-Johnson syndrome, poermal necrolysis yoopsa, dermatitis yodwala kwambiri, pachimake pantulosis yayikulu.

Kuchokera pamikodzo: kawirikawiri - crystalluria, interstitial nephritis, hematuria.

Pa mbali ya chiwindi ndi biliary thirakiti: pafupipafupi - ntchito yowonjezereka ya ALT ndi / kapena AST (izi zimawonedwa mwa odwala omwe amalandira beta-lactam antiotic therapy, koma tanthauzo lake lamankhwala silikudziwika), Zochitika zolakwika kuchokera ku chiwindi zimawonedwa makamaka mwa abambo ndi odwala okalamba ndipo akhoza kuyanjanitsidwa ndi chithandizo cha nthawi yayitali. Zochitika zoyipa izi sizimawonedwa kawirikawiri mwa ana.

Zizindikiro zomwe zalembedwazo zimakonda kuchitika pakumala kapena atangomaliza kumene chithandizo, komabe nthawi zina mwina sangawonekere kwa milungu ingapo atamaliza kulandira chithandizo. Zochitika zoyipa nthawi zambiri zimasinthidwa. Zochitika zoyipa za chiwindi zimatha kukhala zowopsa, nthawi zina pamakhala nkhani zakufa. Pafupifupi nthawi zonse, awa anali odwala omwe ali ndi vuto lalikulu la matenda kapena odwala omwe amalandila mankhwala oopsa a hepatotoxic. Nthawi zambiri - kuchuluka kwa zamchere phosphatase, kuchuluka bilirubin, hepatitis, cholestatic jaundice (anati ndi concomitant mankhwala ndi penicillin ena ndi cephalosporins).

Zina: Nthawi zambiri - candidiasis a pakhungu ndi mucous nembanemba, pafupipafupi sizikudziwika - Kukula kwa tizilombo tating'onoting'ono.

Kuchita

Mitundu yonse yamiyeso

Maantacid, glucosamine, mankhwala othandizira, aminoglycosides amachepetsa kuyamwa, ascorbic acid imawonjezera kuyamwa.

Ma diuretics, allopurinol, phenylbutazone, NSAIDs ndi mankhwala ena omwe amatsekera secretion wa tubular secretion (phenenecid) amawonjezera kuchuluka kwa amoxicillin (clavulanic acid imachotsedwa makamaka ndi kusefera kwa glomerular).

Kugwiritsa ntchito pamodzi kwa Amoxiclav ® ndi methotrexate kumawonjezera kuwopsa kwa methotrexate.

Kukhazikitsidwa pamodzi ndi allopurinol kumawonjezera zochitika za exanthema. Ntchito zofananira ndi disulfiram ziyenera kupewedwa.

Amachepetsa mphamvu ya mankhwala, munthawi ya kagayidwe kamene PABA imapangidwa, ethinyl estradiol - chiopsezo chotaya magazi kwambiri.

Mabukuwa amafotokoza milandu yachilendo ya INR mwa odwala omwe amaphatikizana ndi acenocumarol kapena warfarin ndi amoxicillin. Ngati ndi kotheka, kugwiritsa ntchito nthawi yomweyo ndi anticoagulants, PV kapena INR iyenera kuyang'aniridwa mosamala popereka mankhwala kapena kusiya ntchito.

Kuphatikiza ndi rifampicin ndikutsutsana (kufooka kwa mphamvu ya antibacterial). Amoxiclav ® sayenera kugwiritsidwa ntchito nthawi yomweyo kuphatikiza ma bacteriostatic antibayotiki (macrolides, tetracyclines), sulfonamides chifukwa kuchepa kwa mphamvu ya Amoxiclav ®.

Amoxiclav ® imachepetsa mphamvu ya njira zakulera zamkamwa.

Mapiritsi omwera ndi ufa wowayimitsa pakumwa pamlomo

Zimawonjezera kugwira ntchito kwa anticoagulants osalunjika (kupondereza microflora yamatumbo, kumachepetsa kaphatikizidwe ka vitamini K ndi index ya prothrombin). Nthawi zina, kumwa mankhwalawa kungakulitse PV, motere, kusamala kuyenera kugwiritsidwa ntchito mukamagwiritsa ntchito anticoagulants ndi mankhwala Amoxiclav ® Quicktab.

Probenecid amachepetsa kupukusira kwa amoxicillin, kukulitsa kuchuluka kwake kwa seramu.

Odwala omwe amalandila mycophenolate mofetil, atayamba kugwiritsa ntchito mankhwala osakanikirana a amoxicillin ndi clavulanic acid, kuchepa kwa ndende yogwira metabolic, mycophenolic acid, adawonedwa asanamwe mlingo wotsatira wa mankhwala ndi 50%. Zosintha pamawonekedwe awa sizingawonetse moyenera kusintha kwamtundu wa mycophenolic acid.

Wofera pakukonzekera njira yothetsera utsogoleri wa iv

Mankhwala a Amoxiclav ® ndi aminoglycoside ndiosagwirizana.

Osasakaniza Amoxiclav ® mu syringe kapena kulowetsedwa ndi mankhwala ena.

Pewani kusakanikirana ndi mayankho a dextrose, dextran, sodium bicarbonate, komanso ndi mayankho okhala ndi magazi, mapuloteni, lipids.

Kuyanjana kwa mankhwala osokoneza bongo

Ndi munthawi yomweyo kugwiritsa ntchito Amoxiclav ® ndi maantacididi, glucosamine, mankhwala othandizira, aminoglycosides, mayamwidwe amachepetsa, ndi ascorbic acid imachulukanso.

Ma diuretics, allopurinol, phenylbutazone, NSAIDs ndi mankhwala ena omwe amatseka kubisalira kwa tubular kumawonjezera kuchuluka kwa amoxicillin (clavulanic acid imachotsedwa makamaka ndi kusefera kwa glomerular).

Ndi munthawi yomweyo kugwiritsa ntchito Amoxiclav ® kumawonjezera kawopsedwe a methotrexate.

Pogwiritsa ntchito munthawi yomweyo Amoxiclav ndi allopurinol, zochitika za exanthema zimawonjezeka.

Makonzedwe oyanjana ndi disulfiram ayenera kupewedwa.

Nthawi zina, kumwa mankhwalawa kungakulitse nthawi ya prothrombin, motere, kusamala kuyenera kuchitidwa popereka mankhwala anticoagulants ndi mankhwala Amoxiclav ®.

Kuphatikiza kwa amoxicillin ndi rifampicin ndikutsutsana (pali kufooka kwa mphamvu ya antibacterial).

Amoxiclav ® sayenera kugwiritsidwa ntchito nthawi imodzi ndi mankhwala opatsirana a bacteriostatic (macrolides, tetracyclines), sulfonamides chifukwa cha kuchepa kwa mphamvu ya Amoxiclav.

Probenecid amachepetsa kupukusira kwa amoxicillin, kukulitsa kuchuluka kwake kwa seramu.

Maantibayotiki amathandizira kuchepetsa kupatsirana kwa pakamwa.

Mlingo ndi makonzedwe

Mapiritsi okhala ndi mafilimu

Mkati. Mlingo wa mankhwalawa umayikidwa payekhapayekha, kutengera zaka, kulemera kwa thupi, impso ya wodwalayo, komanso kuopsa kwa matendawa.

Amoxiclav ® ndikulimbikitsidwa kuti idatengedwe kumayambiriro kwa chakudya kuti mayamwidwe bwino komanso kuti muchepetse zotsatirapo zoyipa zamagetsi.

Njira ya mankhwala ndi masiku 5-14. Kutalika kwa nthawi ya chithandizo akutsimikiza ndi dokotala. Kuchiza sikuyenera kupitirira masiku opitilira 14 popanda kupimidwa kachiwiri.

Mlingowo umaperekedwa potengera zaka komanso kulemera kwa thupi. Mlingo woyenera ndi 40 mg / kg / tsiku mu 3 mgawani.

Ana omwe ali ndi thupi lolemera 40 makilogalamu kapena kupitilira ayenera kupatsidwa mlingo wofanana ndi akulu. Kwa ana azaka zapakati pa ≤6, ndikofunikira kwambiri kuyimitsidwa kwa Amoxiclav ®.

Akuluakulu ndi ana opitilira zaka zopitilira 12 (kapena> makilogalamu 40 a kulemera kwa thupi)

Mlingo wamba pofatsa pakamwa pang'ono piritsi limodzi. 250 + 125 mg maola 8 aliwonse kapena piritsi limodzi. 500 + 125 mg maola 12 aliwonse, ngati pali matenda opatsirana kwambiri komanso matenda opatsirana a m'mapapo - 1 tebulo. 500 + 125 mg maola 8 aliwonse kapena piritsi limodzi. 875 + 125 mg maola 12 aliwonse

Popeza mapiritsi osakanikirana a amoxicillin ndi clavulanic acid 250 + 125 mg ndi 500 + 125 mg aliyense amakhala ndi kuchuluka kwa clavulanic acid - 125 mg, ndiye mapiritsi awiri. 250 + 125 mg siofanana ndi piritsi limodzi. 500 + 125 mg.

Mlingo wa matenda odontogenic

1 tabu. 250 + 125 mg maola 8 aliwonse kapena piritsi limodzi. 500 + 125 mg maola 12 aliwonse masiku 5.

Odwala ndi mkhutu aimpso ntchito

Kusintha kwa Mlingo wokhazikika pazotsatira zoyenera za amoxicillin ndipo zimachitika poganizira mfundo za Cl designinine:

- achikulire ndi ana azaka zopitilira 12 (kapena kg40 makilogalamu a kulemera kwa thupi) (tebulo. 2),

- ndi anuria, gawo pakati pa dosing liyenera kuchuluka mpaka maola 48 kapena kupitirira,

- Mapiritsi a 875 + 125 mg ayenera kugwiritsidwa ntchito mwa odwala a Cl creatinine> 30 ml / min.

Mphamvu yakuyimitsidwa pakamwa

Mlingo watsiku ndi tsiku wa kuyimitsidwa ndi 125 + 31.25 mg / 5 ml ndi 250 + 62,5 mg / 5 ml (kutsogolera dosing yoyenera, mu phukusi lililonse la kuyimitsidwa 125 + 31.25 mg / 5 ml ndi 250 + 62,5 mg / 5 ml, piritsi yomaliza maphunziro a 5 ml yokhala ndi kukula kwa 0,5 ml kapena supuni ya 5 ml, imayikidwa. zikwangwani zakale za 2,5 ndi 5 ml).

Makanda obadwa kumene ndi ana mpaka miyezi itatu - 30 mg / kg / tsiku (malinga ndi amoxicillin), logawidwa mu 2 waukulu (maola 12 aliwonse).

Mlingo wa mankhwala Amoxiclav ® ndi dosing pipette - kuwerengetsa Mlingo umodzi zochizira matenda kwa akhanda ndi ana mpaka miyezi 3 (Table 3).

Ana okulirapo kuposa miyezi itatu - kuchokera 20 mg / kg chifukwa cha matenda ofatsa kwambiri mpaka 40 mg / kg pa matenda opatsirana kwambiri komanso kupumira kwamatumbo opatsirana, ma atitis media, sinusitis (amoxicillin) patsiku, omwe amagawidwa katatu.

Mlingo wa mankhwala Amoxiclav ® ndi dosing pipette - kuwerengetsa kwa Mlingo umodzi wowerengeka wa ana opitilira miyezi itatu (kutengera 20 mg / kg / tsiku (la amoxicillin) (Table 4).

Mlingo wa mankhwala Amoxiclav ® ndi pipette Mlingo - kuwerengetsa Mlingo umodzi zochizira matenda akuluakulu ana osaposa miyezi 3 (kutengera 40 mg / kg / tsiku (la amoxicillin) (Table 5).

Mlingo wa mankhwala Amoxiclav ® ndi supuni ya kumwa (pakalibe mlingo wa piritsi) - mlingo woyenera wa kuyimitsidwa kutengera thupi la mwana komanso kuopsa kwa matendawa.

Tsiku lililonse kuyimitsidwa 400 mg + 57 mg / 5 ml

Mlingo amawerengedwa pa kilogalamu iliyonse yakulemera kwa thupi, kutengera kuopsa kwa matendawa. Kuchokera pa 25 mg / kg pa matenda ofatsa kwambiri mpaka 45 mg / kg pa matenda opatsirana kwambiri komanso kupepuka kwa matenda opatsirana, otitis media, sinusitis (malinga ndi amoxicillin) patsiku, logawidwa mu 2 waukulu.

Kuwongolera dosing yoyenera, kuyimitsidwa kwa 400 mg + 57 mg / 5 ml ndikuyikidwa mu phukusi lirilonse la pipette ya mlingo, omaliza nthawi imodzi mu 1, 2, 3, 4, 5 ml ndi magawo 4 ofanana.

Kuyimitsidwa kwa 400 mg + 57 mg / 5 ml amagwiritsidwa ntchito mwa ana okulirapo kuposa miyezi itatu.

Mlingo woyenera wa kuyimitsidwa kutengera thupi la mwana komanso kuopsa kwa matendawa

Mlingo wofanana watsiku ndi tsiku amawerengedwa potengera thupi la mwana, osati zaka zake.

Mlingo wapamwamba wa tsiku lililonse wa amoxicillin ndi 6 ga kwa akulu ndi 45 mg / kg kwa ana.

Mlingo wapamwamba wa tsiku ndi tsiku wa clavulanic acid (munthawi ya mchere wa potaziyamu) ndi 600 mg kwa akulu ndi 10 mg / kg kwa ana.

Odwala ndi mkhutu aimpso ntchito, mlingo uyenera kusintha malinga ndi pazipita mlingo wa amoxicillin.

Odwala omwe ali ndi creatinine Cl> 30 ml / min safuna kusintha kwa mtundu uliwonse.

Akuluakulu ndi ana olemera oposa 40 kg (njira yeniyeniyo ya mankhwalawa imagwiritsidwa ntchito pochotsa matenda osakwanira komanso koopsa)

Odwala a Cl creatinine 10-30 ml / mphindi - 500/125 mg 2 kawiri pa tsiku.

Cl Clininine Cl creatinine 10-30 ml / mphindi, mlingo woyenera ndi 15 / 3.75 mg / kg kawiri pa tsiku (pazambiri 500/125 mg 2 kawiri pa tsiku).

Ndi Cl creatinine iv

Ana: ndi kulemera kwa thupi zosakwana 40 makilogalamu - mlingo amawerengedwa kutengera kulemera kwa thupi.

Osakwana miyezi 3 yokhala ndi kulemera kwa thupi zosakwana 4 kg - 30 mg / kg (malinga ndi mankhwala onse a Amoxiclav ®) maola 12 aliwonse

Pansi pa miyezi itatu ndi thupi lolemera kuposa 4 kg - 30 mg / kg (malinga ndi mankhwala onse a Amoxiclav ®) maola 8 aliwonse

Mwa ana ochepera miyezi 3, Amoxiclav ® imayenera kuperekedwa pang'onopang'ono kwa mphindi 30-40.

Ana kuyambira miyezi itatu mpaka zaka 12 - 30 mg / kg (malinga ndi kukonzekera kwathunthu Amoxiclav ®) ndi nthawi yotalikirapo maola 8, ngati matendawa atenga matenda ambiri - pakadutsa maola 6

Ana omwe ali ndi vuto laimpso

Kusintha kwa Mlingo wokhazikika pazotsatira zoyenera za amoxicillin. Kwa odwala omwe ali ndi Cl creatinine pamtunda wa 30 ml / min, kusintha kwa mlingo sikofunikira.

Ana olemera Cl creatinine 10-30 ml / min25 mg / 5 mg pa 1 kg maola 12 aliwonse Cl creatinine ® imakhala ndi 25 mg ya amoxicillin ndi 5 mg ya clavulanic acid.

Akuluakulu ndi ana opitirira zaka 12 kapena osaposa 40 makilogalamu - 1,2 g ya mankhwalawa (1000 + 200 mg) ndi nthawi yotalikirapo maora 8, ngati ali ndi vuto lalikulu - -

Mlingo wowonjezera wothandiza pakuchitidwa opaleshoni: 1.2 g ndi mankhwala opaleshoni (ndi nthawi ya opaleshoni yochepera maola 2). Kwa ntchito yayitali - 1.2 ga mpaka 4 pa tsiku.

Kwa odwala omwe ali ndi vuto la aimpso, muyezo komanso / kapena pakati pa jakisoni wa mankhwalawa amayenera kusintha malinga ndi kuchuluka kwa kusakwanira:

Popeza 85% ya mankhwalawa imachotsedwa ndi hemodialysis, kumapeto kwa njira iliyonse ya hemodialysis, muyenera kulowa muyezo wa Amoxiclav ®. Ndi peritoneal dialysis, kusintha kwa mankhwala sikofunikira.

Njira ya mankhwala ndi masiku 5-14. Kutalika kwa nthawi ya chithandizo akutsimikiza ndi dokotala. Ndi kuchepa kwa kuopsa kwa zizindikilo, kusintha kwa mitundu yamkamwa ya Amoxiclav ® ndikulimbikitsidwa kuti mupitilize mankhwala.

Kukonzekera kwa mayankho a jakisoni wa iv. Sungunulani zomwe zili mu vial m'madzi a jakisoni: 600 mg (500 + 100 mg) mu 10 ml ya madzi a jakisoni kapena 1.2 g (1000 + 200 mg) mu 20 ml ya madzi a jekeseni. Mu / kulowa kulowa pang'onopang'ono (mkati mwa mphindi 3-4).

Amoxiclav ® iyenera kuperekedwa pakadutsa mphindi 20 pambuyo pokonzekera njira zoyendetsera iv.

Kukonzekera njira zothetsera kulowetsedwa kwa iv. Pa kulowetsedwa kwa Amoxiclav ®, kuchepetsedwa kowonjezereka ndikofunikira: mayankho okonzekera omwe ali ndi 600 mg (500 + 100 mg) kapena 1.2 g (1000 + 200 mg) ya mankhwalawa amayenera kuchepetsedwa mu 50 kapena 100 ml ya kulowetsedwa. Kutalika kwa kulowetsedwa ndi mphindi 30 mpaka 40.

Mukamagwiritsa ntchito zakumwa zotsatirazi pamavuto obwera, maantibayotiki ofunikira amasungidwa:

Njira yothetsera mankhwalawa Amoxiclav ® siyingasakanikirane ndi mayankho a dextrose, dextran kapena sodium bicarbonate.

Mayankho omveka okha ndi omwe ayenera kugwiritsidwa ntchito. Njira zakonzedwa siziyenera kuzizira.

Mkati. Mlingo wa mankhwalawa umayikidwa payekha kutengera zaka, kulemera kwa thupi, ntchito ya impso ya wodwala komanso kuopsa kwa matendawa.

Mapiritsiwo ayenera kusungunuka theka la kapu ya madzi (osachepera 30 ml) ndikusakanizidwa bwino, kenako imwani kapena gwiritsani ntchito mapiritsiwo mkamwa mpaka atasungunuka kwathunthu, kenako ndikumeza.

Pofuna kuchepetsa chiwopsezo cha mavuto obwera chifukwa cha m'mimba, mankhwalawa amayenera kumwedwa kumayambiriro kwa chakudya.

Amoxiclav ® Quicktab Mapiritsi Osiyanasiyana 500 mg / 125 mg:

Akuluakulu ndi ana azaka zopitilira 12 okhala ndi thupi lolemera ≥40 kg

Zochizira matenda ofatsa pang'ono zolimbitsa - 1 tebulo. (500 mg / 125 mg) maola 12 aliwonse (kawiri pa tsiku).

Zochizira matenda opatsirana ndi matenda a kupuma dongosolo - 1 tebulo. (500 mg / 125 mg) maola 8 aliwonse (katatu pa tsiku).

Mlingo wapamwamba wa tsiku ndi tsiku wa Amoxiclav ® Quicktab ndi 1,500 mg ya amoxicillin / 375 mg wa clavulanic acid.

Odwala ndi mkhutu aimpso ntchito. Odwala omwe ali ndi creatinine Cl pamwamba pa 30 ml / mphindi, kusintha kwa mlingo sikofunikira.

Akulu ndi ana a zaka zopitilira 12 okhala ndi thupi lolemera ≥40 kg (njira ya dosing yomwe akuwonetsedwa imagwiritsidwa ntchito pochotsa matenda osakhazikika komanso koopsa):

Akuluakulu ndi ana azaka zopitilira 12 okhala ndi thupi lolemera ≥40 kg

Woopsa matenda ndi kupuma matenda - 1 gome. (875 mg / 125 mg) maola 12 aliwonse (kawiri pa tsiku).

Mlingo wa tsiku ndi tsiku wa mankhwala Amoxiclav ® Quicktab akagwiritsidwa ntchito kawiri pa tsiku ndi 1750 mg ya amoxicillin / 250 mg ya clavulanic acid.

Odwala ndi mkhutu aimpso ntchito. Odwala omwe ali ndi Cl creatinine woposa 30 ml / mphindi, palibe chifukwa chofuna kusintha kwa mlingo.

Kwa odwala omwe ali ndi Cl creatinine osakwana 30 ml / min, kugwiritsa ntchito mapiritsi omwedwa a Amoxiclav ® Quicktab, 875 mg / 125 mg ndi kutsutsana.

Odwala otere amayenera kumwa mankhwalawa pa mlingo wa 500 mg / 125 mg pambuyo pa kusintha kwa mlingo woyenera wa creatinine Cl.

Odwala omwe ali ndi vuto la chiwindi. Mukamamwa Amoxiclav ® Quicktab, muyenera kusamala. Kuwunikira pafupipafupi kwa ntchito ya chiwindi ndikofunikira. Ngati chithandizo chikuyambitsidwa ndi makulidwe a makolo ake, ndizotheka kupitiliza mankhwalawa ndi mapiritsi a Amoxiclav ® Quicktab.

Kutalika kwa nthawi ya chithandizo akutsimikiza ndi dokotala!

Njira yochepetsetsa ya mankhwala opha maantibayotiki ndi masiku 5. Kuchiza sikuyenera kupitilira masiku opitilira 14 osanenapo za matenda.

Mlingo ndi makonzedwe

Mankhwala amatengedwa pakamwa. Mlingo watsiku ndi tsiku umatsimikiziridwa ndi dotolo, chifukwa kuwopsa kwa matendawo komanso kulemera kwa thupi la wodwalayo. Kukonzekera kuyimitsidwa kwa ufa, muyenera kugwedeza botolo, mumtundu wachiwiri muwonjezere kuchuluka kwa madzi omwe akuwonetsedwa pa chizindikiro, sakanizani bwino. Ufa udzasungunuka kwathunthu mkati mwa masekondi khumi ndi anayi ndikupeza madzi akuda. Kuti mumvetsetse momwe mungatenge Amoxiclav, muyenera kudziwa bwino tebulo ili m'munsiyi:

Mlingo

Ufa woyimitsidwa pakamwa, 156.25 mg / 5 ml ndi 312.5 mg / 5 ml

5 ml ya kuyimitsidwa (kipimo 1 cha pipette) chili

ntchito: 125 mg amoxicillin monga amoxicillin trihydrate + 5% yowonjezera kukhazikika kwa 6.25 mg, 31.25 mg clavulanic acid monga potaziyamu clavulanate (kwa mulingo wa 156.25 mg / 5 ml) kapena 250 mg amoxicillin monga amoxicillin trihydrate + 5% yowonjezera chifukwa cha kukhazikika kwa 12,5 mg, 62,5 mg clavulanic acid mu mawonekedwe a potaziyamu clavulanate (Mlingo wa 312,5 mg / 5 ml).

obwera: anhydrous citric acid, anhydrous sodium citrate, ndi microcrystalline cellulose ndi sodium carboxymethyl cellulose, xanthan chingamu, anhydrous colloidal silicon dioxide, silicon dioxide, Strawberry flavour (kwa mulingo wa 156.25 mg / 5 ml), Wild Cherry flavor (kwa Mlingo wa 31,5 mg. / 5 ml), sodium benzoate, sodium saccharin, zouma, mannitol.

Crystalline ufa kuchokera kuzoyera mpaka zachikaso zopepuka.

Kuyimitsidwa mokonzekereratu ndi kuyimitsidwa kokhazikika kuyambira pafupi yoyera mpaka chikaso.

Mankhwala

Pharmacokinetics

Amoxicillin ndi clavulanic acid amasungunuka kwathunthu mu madzi amchere pH ya thupi. Zonsezi ndizoyamwa bwino pakamwa. Mulingo woyenera kumwa amoxicillin / clavulanic acid mukadzayamba kudya. Pambuyo pakamwa, bioavailability wa amoxicillin ndi clavulanic acid pafupifupi 70%. Mphamvu ya kuchuluka kwa mankhwalawa mu plasma ya zigawo zonse ziwiri ndi zofanana. Pazambiri za seramu zimafikira ola limodzi pambuyo pa kukhazikitsa.

Mphamvu ya amoxicillin ndi clavulanic acid mu seramu ya magazi mukamamwa mankhwala a amoxicillin / clavulanic acid ndi ofanana ndi omwe amadziwika ndi pakamwa pokhapokha ngati gawo limodzi la amoxicillin ndi clavulanic acid.

Pafupifupi 25% ya kuchuluka kwathunthu kwa clavulanic acid ndi 18% ya amoxicillin amamangiriza mapuloteni a plasma. Kuchuluka kwa magawa pakamwa pakumwa mankhwala pafupifupi 0.3-0.4 l / kg wa amoxicillin ndi 0,2 l / kg wa clavulanic acid.

Pambuyo pokonzanso mtsempha wamagazi, onse amoxicillin ndi clavulanic acid adapezeka mu chikhodzodzo, mafinya am'mimbamo, khungu, mafuta, minofu yamatumbo, zotumphukira ndi zotumphukira, bile ndi mafinya. Amoxicillin amalowa bwino mu madzi a cerebrospinal.

Amoxicillin ndi clavulanic acid amawoloka placental zotchinga. Zinthu zonsezi zimadutsanso mkaka wa m'mawere.

Amoxicillin amachotsekedwa pang'ono mu mkodzo wofanana ndi penicillic acid wofanana ndi 10-25% ya mlingo woyamba. Clavulanic acid imapangidwa m'thupi ndi kuponyera mkodzo ndi ndowe, komanso mpweya wa mpweya wothira mpweya.

Kuchulukitsa kwapakati theka la moyo wa amoxicillin / clavulanic acid ndi pafupifupi ola limodzi, ndipo kuvomerezeka kokwanira pafupifupi 25 l / h. Pafupifupi 60-70% ya amoxicillin ndi 40-65% ya clavulanic acid amachotsedwa mu mkodzo mkati mwa maola 6 atatha kumwa kamodzi pa mapiritsi a amoxicillin / clavulanic acid. Pa maphunziro osiyanasiyana, zidapezeka kuti 50-85% ya amoxicillin ndi 27-60% ya clavulanic acid amachotsedwa mkodzo mkati mwa maola 24. Kuchuluka kwacrosulanic acid kumachotsedwa pakatha maola 2 mutatha ntchito.

Kugwiritsa ntchito pamodzi kwa phenenecid kumachepetsa kutulutsidwa kwa amoxicillin, koma mankhwalawa samakhudza kutuluka kwa clavulanic acid kudzera mu impso.

Hafu ya moyo wa amoxicillin imakhala yofanana mwa ana a zaka zitatu mpaka ziwiri, komanso mwa ana achikulire ndi akulu. Popereka mankhwala kwa ana aang'ono kwambiri (kuphatikiza ana akhanda) m'milungu yoyamba ya moyo, mankhwalawa sayenera kuperekedwa kawiri patsiku, omwe amalumikizidwa ndi kusakhazikika kwa njira ya impso kwa ana. Chifukwa chakuti odwala okalamba amatha kudwala matenda a impso, mankhwalawa ayenera kuyikidwa mosamala ku gulu la odwala, koma ngati kuli kotheka, kuyang'anira ntchito yaimpso kuyenera kuchitidwa.

Chilolezo chonse cha amoxicillin / clavulanic acid m'madzi am'magazi amachepetsa mwachindunji kuchepa kwa impso. Kuchepa kwa chilolezo cha amoxicillin kumanenedweratu poyerekeza ndi clavulanic acid, chifukwa kuchuluka kwa amoxicillin kumathandizidwa kudzera mu impso. Chifukwa chake, popereka mankhwala kwa odwala omwe amalephera aimpso, kusintha kwa mankhwalawa ndikofunikira kuti muchepetse kuchuluka kwa amoxicillin ndikukhalabe wofunikira clavulanic acid.

Popereka mankhwala kwa odwala omwe ali ndi vuto la chiwindi, muyenera kusamala posankha mlingo ndikuwonetsetsa ntchito ya chiwindi.

Mankhwala

Amoxicillin ndi mankhwala opanga ma cell kuchokera ku penicillin gulu (beta-lactam antiotic) lomwe limalepheretsa ma enzyme amodzi kapena angapo (omwe nthawi zambiri amatchedwa ma penicillin-binding protein) omwe amaphatikizidwa ndi biosynthesis ya peptidoglycan, yomwe ndi gawo lofunikira kwambiri mwa khoma la bakiteriya. Kuletsa kwa peptidoglycan synthesis kumayambitsa kufooka kwa khungu la cell, nthawi zambiri kumatsatiridwa ndi lysis l cell ndi cell cell.

Amoxicillin amawonongeka ndi beta-lactamases opangidwa ndi mabakiteriya osagwira, chifukwa chake zochitika za amoxicillin zokha sizimakhala ndi tizilombo tating'onoting'ono timene timatulutsa michere.

Clavulanic acid ndi beta-lactam mwapangidwe kogwirizana ndi penicillin. Imalepheretsa ma beta-lactamase, potero kuletsa kuyatsidwa kwa amoxicillin ndikukulitsa zochitika zake. Clavulanic acid yokha ilibe mphamvu yokhudza antibacterial.

Nthawi yowonjezereka pamwamba pazowonjezera zochepa zoletsa (T> IPC) imawerengedwa kuti ndiyo yofunika kwambiri yogwira ntchito ya amoxicillin.

Njira ziwiri zomwe zingalimbane ndi amoxicillin ndi clavulanic acid ndi:

- inactivation ndi bacteria beta-lactamases omwe saponderezedwa ndi clavulanic acid, kuphatikiza makalasi B, C ndi D.

- kusintha kwa mapuloteni omangira penicillin, omwe amachepetsa kuyanjana kwa antibacterial wothandizila kuzinthu zomwe mukufuna.

Kusakhudzidwa kwa mabakiteriya kapena njira ya pampu ya efflux (kayendedwe ka zinthu) kumatha kuyambitsa kapena kupitiliza kulimbana ndi mabakiteriya, makamaka mabakiteriya osagwiritsa ntchito gramu.

Wopanga

Lek dd Verovshkova 57, Ljubljana, Slovenia.

Pa ufa pokonzekera yankho la intravenous makonzedwe

1. Lek dd, Verovshkova 57, Ljubljana, Slovenia.

2. Sandoz GmbH, Biohemistrasse 10 A-6250, Kundl, Austria.

Zodandaula za ogula ziyenera kutumizidwa ku Sandoz CJSC: 125317, Moscow, Presnenskaya nab., 8, p. 1.

Tele. ((495) 660-75-09, fax: (495) 660-75-10.

Amoxiclav ®

mafilimu okhala ndi mafilimu 250 mg + 125 mg 250 mg + 125 - zaka 2.

mafilimu okhala ndi mafilimu 500 mg + 125 mg 500 mg + 125 - zaka 2.

mafilimu okhala ndi mafilimu 875 mg + 125 mg 875 mg + 125 - zaka ziwiri.

ufa pokonzekera yankho la mtsempha wa magazi mtsempha wa 500 mg + 100 mg 500 mg + 100 - 2 zaka.

ufa pokonzekera yankho la mtsempha wa magazi mtsempha wa 1000 mg + 200 mg 1000 mg + 200 - zaka 2.

dispersible mapiritsi 500 mg + 125 mg 500 mg + 125 - zaka 3.

dispersible mapiritsi 875 mg + 125 mg 875 mg + 125 - zaka 3.

ufa w kuyimitsidwa kwa makonzedwe amkamwa a 125 mg + 31.25 mg / 5 ml 125 mg + 31.25 mg / 5 - 2 zaka. Kuyimitsidwa kwamaliza ndi masiku 7.

ufa kuyimitsidwa pakamwa makonzedwe a 250 mg + 62,5 mg / 5 ml 250 mg + 62,5 mg / 5 - 2 zaka. Kuyimitsidwa kwamaliza ndi masiku 7.

ufa woyimitsidwa pakumwa kwamlomo 400 mg + 57 mg / 5 ml 400 mg + 57 mg / 5 - 3 zaka. Kuyimitsidwa kwamaliza ndi masiku 7.

Osagwiritsa ntchito tsiku lotha ntchito likusonyezedwa pa phukusi.

Zochita zamankhwala osokoneza bongo

Ma anticoagulants am'magazi komanso maantibayotiki a gulu la penicillin amagwiritsidwa ntchito kwambiri mchitidwe popanda malipoti a mgwirizano. Komabe, m'mabuku mumawonjezeka kuchuluka kwa odwala omwe amatenga acenocoumarol kapena warfarin palimodzi ndi amoxicillin. Ngati kugwiritsa ntchito mankhwala munthawi yomweyo kuli kofunikira, nthawi ya prothrombin kapena kuchuluka kwa mitundu yonse kuyenera kuyang'aniridwa mosamala posankha ndi kufalitsa amoxicillin. Komanso, kusintha kwa muyezo wa mankhwala oteteza pakamwa angafunikire.

Mankhwala a gulu la Penicillin amatha kuchepetsa kuchulukitsidwa kwa methotrexate, komwe kumapangitsa kuchuluka kwa kawopsedwe.

Kugwiritsa ntchito kwapomponecid kosavomerezeka sikulimbikitsidwa. Probenecid amachepetsa impso ya katulutsidwe wa amoxicillin. Kugwiritsa ntchito nthawi yomweyo ndi Amoxiclav kumatha kukulitsa magazi, koma osati clavulanic acid.

Kugwiritsa ntchito munthawi yomweyo allopurinol ndi Amoxiclav kungakulitse chiopsezo cha zotsatira zoyipa. Zambiri pakugwiritsa ntchito munthawi yomweyo allopurinol ndi amoxiclav sizikupezeka.

Odwala omwe amatenga mycophenolate mofetil, akaphatikizidwa ndi mankhwala Amoxiclav, ndende ya yogwira metabolic ya mycophenolic acid ndi koyamba mlingo imachepetsedwa pafupifupi 50%. Kusintha kwa kuchuluka kwa ndende yoyamba kungafanane ndi kusintha kwa kuchuluka kwa mycophenolic acid.

Tulutsani mawonekedwe ndi ma CD

25 g wa ufa amayikidwa mu botolo lagalasi lamtundu wama amber lomwe limatha kukhala ndi 125 ml, lokhathamira ndi makatani apulasitiki oyendetsedwa ndikuwongolera koyambira koyamba.

Botolo 1 yokhala ndi pipette ya muyezo komanso malangizo ogwiritsira ntchito zachipatala m'boma komanso zilankhulo zaku Russia zimayikidwa mukatoni.

Pa nthawi yoyembekezera

Zochita za amoxicillin yolimbana ndi mabakiteriya sizimayambitsa khansa mwachindunji, chifukwa chake, ngati pali umboni womveka, madokotala amawauza kuti azimayi oyembekezera. Ndikofunikanso kudziwa kuti clavulanic acid ndi amoxicillin amathandizidwa pang'ono mkaka wamawere. Izi sizowopsa, koma madokotala nthawi zonse amayang'anira momwe amadyetsedwerako kuti apewe mawonekedwe osayembekezeka a thupi la mwana.

Amoxiclav ya ana

Ndikosavuta kuti thupi laling'ono lizitha kuyamwa mankhwala osokoneza bongo. Pankhani imeneyi, Amoxiclav ya ana (mpaka zaka 12) amawonetsedwa ndi ana mu mawonekedwe a kuyimitsidwa kopanda tanthauzo. Kutengera mlingo, Amoxiclav sikuvulaza thanzi la ana. Chiwerengero choyenera cha kuchuluka kwa mankhwalawa kwa kulemera kwa thupi ndi 40 mg / kg. Mlingo wovomerezeka tsiku lililonse ndi 45 mg / kg. Popewa zovuta, siziyenera kupitirira. Kuchuluka kwa mankhwalawa, mankhwala a Amoxiclav a ana ndi owopsa kwambiri.

Mtengo wa Amoxiclav

Chofunikira kwa wodwala aliyense ndi mtengo wa mankhwalawa omwe adokotala adauza. Madokotala samalimbikitsa kupulumutsa thanzi, komabe, ndizotheka kugula mankhwala omwe ali ndi zotsika mtengo kwambiri ngati antibacterial. Pogula mankhwala omwe ali ndi vuto lofananalo, onetsetsani kuti mukumana ndi dokotala ndikuphunzira malangizo omwe angagwiritsidwe ntchito. Kuti mumvetsetse kuchuluka kwa Amoxiclav ndi mitundu yake, tebulo ili m'munsiyi ithandiza:

Alexandra, wazaka 24. Atam'pitiliza kuzipatala, madokotala anapeza cholecystitis. Amoxiclav kutumikiridwa pakamwa. Ndinawerenga ndemanga pa intaneti, ndinali wokhutira. Imachita mosangalatsa, mtengo wake ndiwomveka. Dokotalayo adakonza ndondomeko yokonzekera njira, yodziwitsa Mlingo wa amoxicillin. Anatinso thupi ndi lamphamvu, achikulire, choncho mankhwalawa sazengereza. Ndipo zidachitika. Ndidachira patatha sabata limodzi.

Victoria, wazaka 27. Zithunzi za chisanu mu chisanu zimawononga kwambiri - zimagwira zilonda zapakhosi. Dokotala adati ndachepetsa chiwindi, motero ndiyenera kuthandizidwa mosamala. Amoxiclav 1000 wapamwamba ufa. Pasanathe sabata ndinamwa 10 ml ya kuyimitsidwa katatu pa tsiku ndipo zonse zidapita. Kuchokera ku mankhwala opha maantibayotiki, matenda anga a chiwindi amayamba kuvuta, koma nthawi imeneyi adawononga. Mapangidwe a kuyimitsidwa kumadziwika ndi thupi langa mwachizolowezi.

Victor, wazaka 37 M'mwezi wa Meyi, mwana adagonekedwa m'chipatala ndi chibayo. Dokotala adalamula kuyimitsidwa kwa mankhwalawa Amoxiclav 125. Chifukwa cha zovuta zamagazi, kuphatikiza anticoagulants kunali kofunikira. Kuwona ndemanga, kuphatikiza kotereku sikolandilidwa, koma kunalibe chosankha. Popewa zovuta, kuchuluka kwa kuyimitsidwa kunachepetsedwa kukhala 32 mg ya amoxicillin pa 1 kg yolemera. Mankhwalawa anali opambana.

Anna, wa zaka 32 Mwezi watha, mwana adadwala. Fungo linadzuka, pakhosi. Chipatalacho adapezeka kuti ali ndi matenda osokoneza bongo. Dotolo adati kuimitsa forte kwa Amoxiclav kudzathandiza. Adanenanso kuti zigawo za mankhwalawa zimatha kuthana ndi nthendayi. Adandiwuzani za momwe angagwiritsire ntchito - kumwa 5 ml a amoxicillin katatu patsiku. Sungani kuyimitsidwa mufiriji. Anachira m'masiku atatu, ndipo palibe ziwombolo.