Glyclazide mapiritsi 30 mg: malangizo ogwiritsira ntchito

Hypoglycemic wothandizira, womwe ndi wochokera ku m'badwo wa sulfonylurea II. Imathandizira kupanga insulin ndi ma cell a β ndikubwezeretsa mbiri yake. Kumwa mankhwalawa kumachepetsa nthawi kuyambira nthawi yomwe mudya mpaka kuyamba kwa insulin, popeza imabwezeretsa gawo loyamba (loyambirira) la secretion ndikuthandizira gawo lachiwiri. Kuchepetsa nsonga ya shuga kumatha kudya. Kuchulukitsa kumverera kwa minofu ku insulin.
Kuphatikiza apo, amachepetsa chiopsezo. thrombosispoletsa kuphatikiza ndi kudziphatika kuchuluka kwa mapulateletikubwezeretsa parietal yokhudza thupi fibrinolysisbwino microcirculation. Izi ndizofunikira chifukwa zimachepetsa chiopsezo chovuta kwambiri - retinopathies ndi michereopathies. Ndi diabetesic nephropathy, pali kuchepa proteinuria motsutsana kumbuyo kwake kwa mankhwalawa. Zimalepheretsa chitukuko cha atherosulinosis, chifukwa zimakhala ndi anti-atherogenic katundu.

Mawonekedwe a fomu ya mlingo Gliclazide MV kupereka othandizira achire kwambiri ndi kuwongolera minyewa mkati mwa maola 24.

Pharmacokinetics

Kutenga msanga m'mimba, kuchuluka kwa mayamwidwe kumakhala kwakukulu. Kuzindikira kwakukulu (komwe kumatengedwa 80 mg) kumatsimikiziridwa pambuyo pa maola 4. Kuyankhulana ndi mapuloteni mpaka 97%. Kufanana kwa ndende kumachitika pambuyo pa masiku awiri. Zimapukusidwa mu chiwindi mpaka 8 metabolites. Mpaka 70% imachotsedwa impso, matumbo - 12%. Kuchotsa hafu ya moyo wamba wa gliclazide ndi maola 8, kupitilira maola 20.

Contraindication

• insulin amadalira matenda a shuga,
• ketoacidosis,
• wodwala matenda ashuga,
• kwambiri aimpso / chiwindi kukanika,
• kobadwa nako lactose tsankho, malabsorption syndrome,
• phwando munthawi yomweyo Danazol kapena Phenylbutazone,
• wazaka 18
• Hypersensitivity
• Mimba, kuyamwa.

Amalandira mosamala ukalamba, zakudya zosakhazikika, hypothyroidism, hypopituitarismkoopsa Matenda a mtima wa Ischemicndi kutchulidwa atherosulinosis, adrenal kusowachithandizo cha nthawi yayitali glucocorticosteroids.

Zotsatira zoyipa

• mseru, kusanza, kupweteka m'mimba,
• thrombocytopenia, erythropenia, agranulocytosis, hemolytic anemia,
• matupi awo onse vasculitis,
• zotupa pakhungu, kuyabwa,
• kulephera kwa chiwindi,
• kuwonongeka kwamawonekedwe
• hypoglycemia(pankhani ya bongo).

Glyclazide, malangizo ogwiritsira ntchito (Njira ndi Mlingo)

Mapiritsi a Glyclazide zotchulidwa koyamba tsiku lililonse 80 mg, kumwedwa 2 pa tsiku kwa mphindi 30 asanadye. M'tsogolomu, mlingo umasinthidwa, ndipo pafupifupi tsiku lililonse mumakhala anthu 160 mg, ndipo pazokwanira ndi 320 mg. Mapiritsi a Glyclazide MB amatha kuzindikira mapiritsi otulutsidwa nthawi zonse. Kuthekera kwatsopano ndi kumwa pankhaniyi kumatsimikiziridwa ndi adokotala.

Glyclazide MB 30 mg kumwa 1 nthawi patsiku ladzala. Kusintha kwa mankhwalawa kumachitika pambuyo pa milungu iwiri ya chithandizo. Ikhoza kukhala 90 -120 mg.

Mukaphonya piritsi simungathe kumwa pawiri. Mukalowetsa mankhwala ena ochepetsa shuga ndi izi, nthawi yosinthika sifunikira - amayamba kumwa tsiku lotsatira. Mwina kuphatikiza ndi khwawa, insulinalpha glucosidase zoletsa. Pofatsa pang'ono kulephera kwa aimpso woikidwa chimodzimodzi. Odwala omwe ali pachiwopsezo cha hypoglycemia, mlingo wochepa umagwiritsidwa ntchito.

Bongo

Mankhwala osokoneza bongo amawonetsedwa ndi zizindikiro za hypoglycemia: mutu, kutopa, kufooka kwambiri, thukuta, palpitations, kuthamanga kwa magazi, arrhythmiakugona chipwirikitiukali, kusakwiya, kuchedwa kuchitapo kanthu, kusawona bwino ndi kuyankhula, kunjenjemerachizungulire kukokana, bradycardiakulephera kudziwa.

Ndi odziletsa hypoglycemiaosazindikira msanga, kuchepetsa kuchuluka kwa mankhwalawo kapena kuwonjezera kuchuluka kwa chakudya choperekedwa ndi chakudya.

M'magawo akulu a hypoglycemic, kugonekedwa kuchipatala mwachangu ndi thandizo ndikofunikira: iv 50 ml ya njira ya 20-30% ya shuga, ndiye 10% dextrose kapena glucose solution ikuwukha. Pakupita masiku awiri, kuchuluka kwa shuga kumayang'aniridwa. Kudina osagwira ntchito.

Kuchita

Ntchito mogwirizana Cimetidinezomwe zimawonjezera chidwi gliclazidezomwe zingayambitse hypoglycemia.

Mukamagwiritsa ntchito Verapamil muyenera kuyang'anira kuchuluka kwa shuga.

Mphamvu ya hypoglycemic imatha kugwiritsidwa ntchito ngati salicylateszotumphukira Pyrazolone, sulfonamides, khofi, Phenylbutazone, Theofylline.

Kugwiritsa ntchito ma beta-blockers osasankha kumawonjezera ngozi hypoglycemia.

Mukamagwiritsa ntchito Acarbosezolembedwa zowonjezera hypoglycemic zotsatira.

Mukamagwiritsa ntchito GCS (kuphatikiza mitundu yakunja yogwiritsira ntchito), barbiturates, okodzetsa, estrogenndi ma progestin, Diphenin, Rifampicin kutsitsa kwa shuga kwa mankhwalawa kumachepa.

Ndemanga za Gliclazide

Pakadali pano, zotumphukira zimagwiritsidwa ntchito kwambiri.m'badwo II sulfonylureas, komwe Gliclazide ndi yake, chifukwa ndioposa mankhwala am'badwo wapambuyo mwa zovuta za hypoglycemic, popeza chiyanjano cha β-cell receptors ndi nthawi 2-5, zomwe zimapangitsa kukwaniritsa izi mukamapereka milingo yaying'ono. Mbadwo uno wa mankhwalawa suvuta kuyambitsa mavuto.

Chizindikiro cha mankhwalawa ndikuti ma metabolites angapo amapangidwa panthawi ya kusintha kwa kagayidwe kachakudya, ndipo imodzi mwa izo imakhudzanso ma microcirculation. Kafukufuku wambiri wawonetsa chiopsezo chochepetsetsa cha zovuta za microvascular (retinopathyndi nephropathy) mankhwalawa gliclazide. Kukula kumachepa angiopathy, zakudya zamagulu onse zimakhala bwino, zimazimiririka mtima stasis. Chifukwa chake amalembera zovuta matenda ashuga (angiopathy, nephropathyndi matenda oyamba a impso, retinopathies) ndipo izi zimanenedwa ndi odwala omwe, pazifukwa izi, adasinthidwa kuti amwe mankhwalawa.

Ambiri amagogomezera kuti mapiritsi amayenera kumwedwa pambuyo pa chakudya cham'mawa, chomwe chili ndi chakudya chokwanira, kufa ndi njala masana sikuvomerezeka. Kupanda kutero, motsutsana ndi maziko azakudya zochepa zopatsa mphamvu ndikuchita zolimbitsa thupi kwambiri, chitukuko ndichotheka hypoglycemia. Ndi kupsinjika kwakuthupi, ndikofunikira kusintha mlingo wa mankhwalawa. Atamwa mowa, anthu ena amakhalanso ndi mikhalidwe ya hypoglycemic.

Okalamba amamvera kwambiri mankhwala a hypoglycemic, chifukwa chiopsezo chawo chokhala ndi hypoglycemia chikuwonjezeka. Mothandizirana ndi izi, ndi bwino kugwiritsa ntchito mankhwala osakhalitsa (abwinobwino gliclazide).
Odwala amawunika mu malingaliro awo momwe amafunikira kugwiritsa ntchito mapiritsi osinthika osinthika: amachita pang'onopang'ono komanso moyenera, kotero, amagwiritsidwa ntchito kamodzi patsiku. Kuphatikiza apo, mlingo wake wogwira ntchito umakhala wocheperako kawiri kuposa momwe amaperekera gliclazide.

Pali malipoti kuti patadutsa zaka zingapo (kuyambira 3 mpaka 5 kuyambira pachiyambire), kukana kumayamba - kuchepa kapena kusowa kwa kanthu kwa mankhwalawa. Zikatero, adotolo amasankha kuphatikiza kwa ena othandizira a hypoglycemic.

Mlingo ndi makonzedwe

Ndikulimbikitsidwa kumeza piritsi lonse nthawi yam'mawa popanda kutafuna kapena kuphwanya. Mlingo uliwonse umayenera kusankhidwa payekha, kutengera kuchuluka kwa shuga m'magazi ndi glycosylated hemoglobin.

Mlingo woyenera wokhazikitsidwa kwa akuluakulu (kuphatikizapo okalamba ≥ zaka 65) ndi 30 mg / tsiku. Ngati mutha kuwongolera mokwanira, mankhwalawa atha kugwiritsidwa ntchito pa mankhwalawa. Ndi osakwanira pakuwongolera glycemic, mlingo wa tsiku ndi tsiku ungathe kuchuluka mpaka 60 mg, 90 mg kapena 120 mg. Kukula kwa mankhwalawa ndikotheka osati kale kuposa pambuyo pa mwezi umodzi wa chithandizo chamankhwala omwe adagwiritsidwa kale. Mlingo wa tsiku ndi tsiku ndi 30-120 mg mu 1 mlingo. Pazipita la tsiku lililonse lofika 120 mg. Mukaphonya mtundu umodzi kapena zingapo za mankhwalawa, simungalandire mlingo wambiri muyezo lotsatira, mlingo womwe mwasowa uyenera kumwedwa tsiku lotsatira.

Kusintha pakumatenga mapiritsi a gliclazide osasinthika kupita ku gliclazide 30 mapiritsi osinthika otulutsidwa: 1 tabo. 80 mg yachilendo yotulutsidwa gliclazide imatha kusinthidwa ndi 1 tabu. 30 mg yosinthira glyclatone. Posamutsa odwala kuchokera ku mankhwala a gliclazide 80 mg kupita ku gliclazide MV 30 mg, tikulimbikitsidwa kuwunika bwino kuchuluka kwa shuga m'magazi.

Kuphatikizidwa ndi mankhwala ena a hypoglycemic: Glyclazide-Borimed MV 30 mg ingagwiritsidwe ntchito limodzi ndi biguanidines, alpha-glucosidase inhibitors kapena insulin.

Ndi osakwanira pakuwongolera glycemic, insulin mankhwala imapangidwanso ngati imayang'aniridwa mosamala kuchipatala.

Kukonza mlingo wa mankhwalawa anthu opitirira zaka 65, komanso odwala aimpso kulephera kufatsa kwambiri.

Zotsatira zoyipa

Kuchokera m'mimba: dyspepsia (mseru, kusanza, kutsegula m'mimba, kupweteka kwam'mimba, kudzimbidwa) - zovuta zimachepa ndi chakudya, kawirikawiri - kukanika kwa chiwindi (hepatitis, cholestatic jaundice - kumafuna kusiya mankhwala, kuwonjezeka kwa ntchito ya "chiwindi" transaminases, zamchere phosphatase.

Kuchokera ku ziwalo za hemopoietic: chopinga cha mafupa hematopoiesis (magazi m'thupi, thrombocytopenia, leukopenia, granulocytopenia).

Thupi lawo siligwirizana: kuyabwa pakhungu, urticaria, zotupa pakhungu, kuphatikizapo maculopapular ndi bullous), erythema, matupi awo saviyo vasculitis.

Mawonekedwe a hypoglycemia: chizungulire, kutopa, kugona, kupweteka mutu ndi thukuta, kufooka, mantha, kunjenjemera, paresthesia. Zizindikiro zina zotheka za hypoglycemia: njala, kusokonezeka kwa kugona, kusokonezeka, kupsa mtima, kusachedwa kuyambitsa, kupsinjika, kusokonezeka, mawonekedwe am'maganizo ndi kuyankhula, aphasia, paresis, kusokonezeka kwa malingaliro, kumva kusatha, kulephera kudziletsa, kuperewera, kukokana, kupuma pafupipafupi, bradycardia, kugona, komanso kusazindikira, zomwe zingayambitse kupuma komanso kufa.

Kuphatikiza apo, zizindikiro za kutsutsana ndi adrenergic zimatha kukhazikika, monga thukuta, khungu la nkhawa, nkhawa, tachycardia, kuthamanga kwa magazi, kukhumudwa kwa mtima, angina pectoris ndi mtima. Mwachizolowezi, mawonetseredwe azachipatala nthawi zambiri amatha atatha kudya shuga (shuga). Zokomera zotsekemera zilibe mphamvu yakuyimitsa hypoglycemia. Zomwe tikugwiritsa ntchito kukonzekera kwina kwa sulfonylurea zikuwonetsa kuthekanso kuyambiranso kwa hypoglycemia ngakhale pakadachitika kuti njira zomwe zidagwiritsidwa ntchito pochotsa poyamba zidawoneka ngati zothandiza. Mukuvutikira kwambiri ndi protocol ya hypoglycemia, ndipo ngakhale itathetsedwa kwakanthawi chifukwa chotenga shuga, kulandira chithandizo chamankhwala mwachangu kapena kuchipatala ndikofunikira.

Zowonongeka: Kusokonezeka kwakanthawi kwakanthawi ndizotheka, makamaka kumayambiriro kwa chithandizo, chifukwa cha kusintha kwamagazi a shuga.

Kuchokera pamtima.

Zolemba ntchito

Itha kuthandizidwa kwa odwala omwe kudya kwawo nthawi zonse ndikuphatikiza chakudya cham'mawa. Ndikofunika kwambiri kuti azikhala ndi chakudya chamagulu ambiri monga chakudya Chiwopsezo cha kukhala ndi hypoglycemia chimawonjezeka ndi kusakhazikika kapena kuperewera kwa zakudya m'thupi, komanso kudya zakudya zopanda chakudya. Hypoglycemia nthawi zambiri imayamba kukhala ndi zakudya zochepa zopatsa mphamvu, pambuyo pochita masewera olimbitsa thupi kwa nthawi yayitali kapena mwamphamvu, mutamwa mowa, kapena mumamwa mankhwala angapo a hypoglycemic nthawi yomweyo. Nthawi zambiri, zizindikiro za hypoglycemia zimatha pambuyo podya chakudya chopatsa thanzi (monga shuga). Tiyenera kukumbukira kuti kutenga zotsekemera sikumathandiza kuthetsa zizindikiro za hypoglycemic. Hypoglycemia imatha kubwereranso ngakhale mutakhala kuti mwapumira. Ngati zizindikiro za hypoglycemic zimakhala ndi chikhalidwe chotchulidwa kapena ndizokhalitsa, ngakhale pakhale kusintha kwakanthawi mutatha kudya chakudya chamafuta ambiri, chithandizo chamankhwala chodzidzimu ndikofunikira, mpaka kuchipatala.

Ngakhale kumwa mankhwalawa, kutsimikiza kusala kudya kwa magazi ndi glycosylated Hb ndikofunikira.

Matenda opatsirana omwe ali ndi febrile syndrome angafunike kuthetsedwe kwa mankhwala amkamwa a hypoglycemic ndi makonzedwe a insulin.

Odwala ayenera kuchenjezedwa za chiwopsezo chowonjezereka cha hypoglycemia ngati atha kumwa mankhwala okhala ndi ethanol ndi ethanol (kuphatikizapo kukula kwa zochita za disulfiram: kupweteka kwam'mimba, nseru, kusanza, kupweteka mutu), NSAIDs, ndi njala.

Kusintha kwa mlingo ndikofunikira pakulimbitsa thupi ndi malingaliro, kusintha zakudya.

Chiwopsezo chowonjezereka cha kukhala ndi hypoglycemia chimadziwika pazochitika zotsatirazi: kukana kwa wodwala kapena kulephera (makamaka okalamba) kutsatira zomwe dokotala wamupatsa ndikuwongolera mkhalidwe wake, chakudya chosakwanira komanso chosagwirizana, kulumpha chakudya, kusala kudya ndikusintha zakudya, kusayenerana ndi zochitika zolimbitsa thupi komanso kuchuluka kwa chakudya chotengedwa, komanso aimpso. kusakwanira kapena kufinya kwambiri kwa chiwindi, bongo wa MV gliclazide, zovuta zina za endocrine (matenda a chithokomiro, pituitary ndi adrenal kusakwanira).

Odwala omwe ali ndi vuto lalikulu la hepatic komanso / kapena aimpso, kusintha kwa pharmacokinetic ndi / kapena pharmacodynamic zimatha gliclazide. Hypoglycemia yomwe imayamba mwa odwala imatha kukhala yotalikirapo, mwanjira zotere, chithandizo choyenera chofunikira ndikofunikira.

Ndikofunikira kudziwitsa wodwalayo ndi abale ake za chiwopsezo cha kukhala ndi hypoglycemia, Zizindikiro zake komanso zikhalidwe zomwe zikugwirizana ndi chitukuko chake. Wodwala ayenera kudziwitsidwa za zoopsa zomwe zingachitike ndi chithandizo cha chithandizo chomwe akufuna. Wodwala amafunika kufotokoza bwino kufunika kwa kudya, kufunika kochita masewera olimbitsa thupi pafupipafupi komanso kuwunika pafupipafupi kuchuluka kwa shuga m'magazi.

Munthawi ya chithandizo, chisamaliro chikuyenera kuchitika poyendetsa magalimoto ndi kuchita zina zomwe zingakhale zoopsa zomwe zimafunikira chidwi chochulukirapo komanso kuthamanga kwa zochitika zama psychomotor.

Njira zopewera kupewa ngozi

Okalamba, osakhazikika komanso / kapena osagwiritsidwa ntchito mokwanira, matenda oopsa a mtima (kuphatikizapo mtima wamkati, matenda a m'matumbo), hypothyroidism, adrenal kapena pituitary insuffence, hypopituitarism, aimpso ndi / kapena kulephera kwa chiwindi, kuchuluka kwa glucocorticosteroid , shuga-6-phosphate dehydrogenase akusowa, chithandizo chogwirizana ndi phenylbutazone ndi danazole.

Hypoglycemia. Mankhwala a Gliclazide amatha kuperekedwa kwa odwala omwe amatha kudya pafupipafupi (kuphatikizapo chakudya cham'mawa).Chiwopsezo cha hypoglycemia chimawonjezeka ndi kadyedwe kochepa kopatsa mphamvu, mutatha nthawi yayitali kapena kuchita masewera olimbitsa thupi mopitirira muyeso, kumwa mowa, kapena mukugwiritsidwa ntchito kophatikizana kwa mankhwala angapo a hypoglycemic ochokera ku gulu la sulfonylurea.

Kuperewera kwa chiwindi kapena impso. Mwa odwala, zigawo za hypoglycemia zitha kukhala zazitali, zomwe zimafuna kukhazikitsidwa kwa zinthu zokwanira.

Kuchita bwino kwa mankhwala aliwonse amkamwa a hypoglycemic, kuphatikizapo gliclazide, odwala ambiri amatsika pakapita nthawi: izi zitha kukhala chifukwa cha kuchuluka kwa matenda ashuga kapena kufooka chifukwa cha mankhwalawa.

Kutulutsa mawonekedwe ndi kapangidwe kake

Fomu ya Mlingo - mapiritsi olimbitsa - oyera kapena oyera, biconvex, 30 mg ndi 60 mg chowulungika, 90 mg wa kapangidwe kake, G90 wolemba mbali imodzi (30 mg: ma PC 10). , pamakatoni okhala ndi matuza 3, 6 kapena 9, ma CD 15 amodzi pachimake, pamatampu a makatoni 2, 4 kapena 6, 60 mg uliwonse: ma PC 15 pachimake, m'khadilo la matuza 2, 4, 6 kapena 8 , 90 mg: ma PC 10. Pakutupa, pakatundu kamatamba 3, 6 kapena 9 matuza.

Piritsi limodzi lili:

• yogwira mankhwala: gliclazide - 30 mg, 60 mg kapena 90 mg,
• zotuluka: hypromellose (100 mPas - mamasukidwe amadzimadzi a 2% yankho lamadzi), lactose monohydrate, colloidal silicon dioxide, magnesium stearate.

Kuphatikiza apo, m'mapiritsi a 30 mg - hypromellose (4000 mPas), calcium carbonate.

Zizindikiro zogwiritsidwa ntchito

Kugwiritsidwa ntchito kwa Glyclades kukuwonetsedwa pochiza odwala akuluakulu omwe ali ndi matenda a shuga 2 omwe amalephera kugwiritsa ntchito mankhwala othandizira, zolimbitsa thupi komanso kuwonda.

Kuphatikiza apo, mankhwalawa adapangidwa kuti apewe mavuto a odwala omwe ali ndi matenda a shuga 2: kuchepetsa chiopsezo cha microvascular (retinopathy, nephropathy) ndi macrovascular (myocardial infarction, stroke).

Mlingo ndi makonzedwe

Mapiritsi amatengedwa pakamwa pakudya m'mawa, 1 nthawi patsiku.

Mlingo wa Glyclades umatchulidwa payekhapayekha malinga ndi kuchuluka kwa hemoglobin wa glycosylated (HbAlc) komanso kuwunika kawirikawiri magazi.

Mlingo wovomerezeka tsiku lililonse: mlingo woyambirira ndi 30 mg, ngati mankhwalawa amalola kuti mukwaniritse bwino kwambiri matenda, amatengedwa ngati kukonza. Popeza pakufunika pakuwongolera glycemic, mankhwalawa amayenera kuwonjezeka pang'onopang'ono (makamaka kuchuluka kwa shuga m'magazi) mpaka 60 mg, 90 mg kapena 120 mg patsiku. Ngati kuchepa kwa shuga m'magazi kumachitika pakatha milungu iwiri, mankhwalawa atha kuwonjezeredwa pakapita milungu inayi kapena kupitilira apo. Ngati pakatha milungu iwiri mukugwiritsa ntchito mankhwalawa, kuchuluka kwa shuga m'magazi sikuchepa, mlingo uyenera kuwonjezeka kumapeto kwa sabata lachiwiri la chithandizo.

Mlingo wapamwamba tsiku lililonse ndi 120 mg.

Mukasankha kumwa mapiritsi otulutsa omwe ali ndi 80 mg ya glyclazide, ziyenera kukumbukiridwa kuti mphamvu ya piritsi limodzi lomweli ndi yofanana ndi 30 mg ya piritsi ya Gliclada. Kusintha mankhwalawa kuyenera kutsagana ndi kuyang'anira kuchuluka kwa shuga m'magazi.

Mlingo woyambirira wa mankhwalawa posintha kuchokera ku mtundu wina uliwonse (ngakhale waukulu) wam'mbuyomu

Hypoglycemic m`kamwa othandizira ayenera kukhala 30 mg. Pankhaniyi, ndikofunikira kuganizira za kuchuluka kwa mphamvu, nthawi komanso nthawi yayitali ya zochita za wothandizira wakale.

Ngati wothandizila kale wa hypoglycemic anali ndi T yayitali_1/2pofuna kupewa zowonjezera komanso kukula kwa hypoglycemia, kuleka kwa mankhwala kwakanthawi (masiku angapo). Pambuyo poyambiranso chithandizo, ndikofunikira kutsagana ndi masabata awiri mpaka awiri kuwunika kwa wodwalayo.

Mankhwalawa amatha kugwiritsidwa ntchito limodzi ndi Biguanides, zotupa za thiazolidatedione, alpha-glucosidase inhibitors kapena insulin.

Kuyambitsa mankhwala osakanikirana ndi insulin ndikofunikira kuyang'aniridwa mosamala ndi madokotala.

Ndi kufatsa komanso kufatsa kwa aimpso, kulengedwa kwa creatinine chilolezo (15) cha 15-80 ml / mphindi, chithandizo cha odwala osaposa zaka 65 sichifunikira kusintha kwa mlingo.

Kuti tikwaniritse gawo la HbAlc, kuphatikiza pakuwonjezera pang'onopang'ono mu mlingo wa mankhwalawa, ndikofunikira kutsatira mosamalitsa zakudya zapadera ndikuchita masewera olimbitsa thupi.

Malangizo apadera

Mukamagwiritsa ntchito mankhwala a Glyclades, wodwalayo ayenera kutsatira chakudya chokhazikika, onetsetsani kuti akuphatikiza chakudya cham'mawa, popeza kudya mochulukirapo kwa zakudya zamafuta, chakudya chakumbuyo kapena osakwanira kuchuluka kwake kumawonjezera chiopsezo cha hypoglycemia. Zizindikiro za hypoglycemia: njala yayikulu, kupweteka mutu, nseru, kusanza, kuchuluka kwaukali, kupsa mtima, kusokonezeka, kusowa tulo, kulephera kulozera, chizungulire, kuzengereza kuchitapo, kupsinjika, kugwedezeka, phokoso, phokoso , kusokonezeka kwa malingaliro, kulephera kudziletsa, kupsinjika, kupuma, bradycardia, kupuma kosakhazikika, kutaya chikumbumtima. Kuphatikiza apo, wodwalayo amatha kupeza thukuta lochulukirapo, nkhawa, kuthamanga kwa magazi, tachycardia, palpitations, angina pectoris, mtima arrhythmias, wodwala komanso khungu lozizira.

Kuti muchepetse kusintha kwa hypoglycemic, ndikofunikira kumwa chakudya (shuga), pamavuto akulu, chithandizo chamankhwala mwadzidzidzi chimafunika.

Kugwiritsa ntchito kudziyang'anira pawokha kuchuluka kwa shuga m'magazi am'magazi kumakupatsani mwayi wolembera kusintha kwa momwe wodwalayo alili.

Kutsatira kwambiri malangizo a dosing - kumwa mankhwalawa pakudya kadzutsa - kumachepetsa mwayi wokhala ndi vuto losafunikira mu mawonekedwe a dyspepsia.

Zizindikiro za cholestatic jaundice zikaonekera, mapiritsi amayenera kulekedwa.

Kuthana ndi zakudya zochepa zopatsa mphamvu, kuchita zinthu zolimbitsa thupi nthawi yayitali kapena kuchita zinthu zina zambiri, kugwiritsa ntchito nthawi yomweyo mankhwala ena oledzera, kumwa mowa kapena kugwiritsa ntchito mankhwala osokoneza bongo kumawonjezera chiopsezo cha hypoglycemia.

Zomwe zimawonjezera chiopsezo cha hypoglycemia zimaphatikizira ndi ma pathologies okhudzana: aimpso, kukanika kwambiri kwa chiwindi, matenda a chithokomiro, kusowa kwa pituitary-adrenal, hypopituitarism. Kusintha kwa mphamvu ya gliclazide mu hepatic kapena kupweteka kwambiri kwaimpso kungayambitse wodwalayo nthawi yayitali ya hypoglycemia.

Simungasokoneze kuchuluka pakati pa kuchuluka kwa chakudya chamafuta, masewera olimbitsa thupi komanso kupsinjika mtima.

Kugwiritsa ntchito mankhwala ena kumatsutsana popanda kufunsa dokotala.

Kuchepa kwa mphamvu ya mankhwala amkamwa hypoglycemic kumatha kuchitika ndi febrile syndrome, zoopsa, matenda opatsirana, kuwotcha kwakukulu, ndikuchita opareshoni. Izi zitha kubweretsa kufunika koti asamutse wodwala kuti apatsidwe insulin.

Tiyenera kudziwa kuti munthawi yomweyo kugwiritsa ntchito ma beta-blockers, reserpine, clonidine, guanethidine amatha kuteteza chiwonetsero cha matenda a hypoglycemia.

Ndi kuchepa kwa achire zotsatira za mankhwala atatenga nthawi yayitali, dokotala akuyenera kuwonetsetsa kuti wodwalayo amatsatira malangizo a dosing regimen, zakudya komanso zolimbitsa thupi. Ngati wodwalayo amatsatira iwo mosamala, ndiye kuti kuchepa kwa kayendedwe ka glycemic kumachitika chifukwa cha kupita patsogolo kwa matendawa.

Kugwiritsa ntchito ma glycase ngati vuto la kuchepa kwa glucose-6-phosphate dehydrogenase kungayambitse kuchepa kwa magazi m'thupi.

Munthawi yogwiritsira ntchito mankhwalawa, ndikulimbikitsidwa kuti odwala matenda a shuga azisamala poyendetsa magalimoto ndi machitidwe awo.

Kuyanjana kwa mankhwala osokoneza bongo

Pogwiritsa ntchito nthawi yomweyo a Glyclades:

• miconazole, phenylbutazone, danazole, ethanol amachititsa kuchuluka kwa mankhwala a hypoglycemic, kuonjezera ngozi ya hypoglycemia, chikomokere,
• insulin, biguanides, acarbose, beta-blockers, sulfonamides, angiotensin kutembenuza enzyme inhibitors (enalapril, Captopril), fluconazole, cimetidine, monoamine oxidase inhibitors, mankhwala omwe si a antiidal
• Chlorpromazine wokwanira (oposa 100 mg pa tsiku) Mlingo umachulukitsa kuchuluka kwa shuga m'magazi, kumachepetsa katemera wa insulin,
• tetracosactide, GCS yodziwika, yogwiritsa ntchito mkati, kunja komanso masekondi amawonjezera mwayi wokhala ndi ketoacidosis,
• salbutamol, ritodrin, terbutaline amawonjezera magazi,
• warfarin ndi anticoagulants ena amathandizira pochiritsa.

Ma fanizo a Gliklad ndi awa: mapiritsi - Diabeteson MV, Gliclazide MV, Diabefarm MV, Glidiab.

Mlingo

30 mg ndi 60 mg mapiritsi osinthidwa otulutsidwa

Piritsi limodzi lili:

ntchito yogwira - gliclazide 30.0 mg kapena 60.0 mg,

zokopa: silicon diokosi woipa wa m'magazi, hydroxypropyl methylcellulose, sodium stearyl fumarate, talc, lactose monohydrate.

Mapiritsi ndi oyera kapena pafupifupi oyera, owoneka bwino ngati cylindrical lapansi ndi bevel (mlingo wa 30 mg).

Mapiritsi ndi oyera kapena pafupifupi oyera mtundu, ozungulira mawonekedwe ndi mawonekedwe a cylindrical, facet ndi notch (Mlingo wa 60 mg).

Mankhwala

Pharmacokinetics

Pambuyo pakamwa, gliclazide imadzaza kwathunthu kuchokera kumimba. Kudya sizimakhudza kuchuluka kwa mayamwidwe. Kuchulukana kwa gliclazide mu plasma kumawonjezeka pang'onopang'ono mkati mwa maola 6 atatha kukhazikitsa ndikufika kumapanga omwe akupitilira kuyambira 6 mpaka 12 ora. Kusintha kwamitundu iwiri ndiocheperako. Ubale pakati pa mlingo mpaka 120 mg ndi plasma yokhotakhota ya mankhwalawa ndi njira yodalira nthawi. Pafupifupi 95% ya mankhwalawa amamangiriza mapuloteni a plasma.

Gliclazide imapangidwa makamaka mu chiwindi ndipo imapukusidwa makamaka mkodzo. Excretion imachitika makamaka ndi impso mu mawonekedwe a metabolites, ochepera 1% amachotsedwa osasinthika mumkodzo. Palibe metabolites yogwira mu plasma.

Hafu ya moyo (T1 / 2) wa gliclazide pafupifupi maola 16 (maola 12 mpaka 20).

Okalamba, palibe kusintha kwakukulu pama paracminetic paraceter.

Mlingo wa tsiku limodzi wa 60 mg umathandiza kugwiriridwa kwa plasma kwa maola oposa 24.

Mankhwala

Gliclazide MV ndi mankhwala osokoneza bongo a hypoglycemic ochokera ku gulu la II m'badwo wa sulfonylurea, omwe amasiyana ndi mankhwala omwewo mwa kukhalapo kwa mphete ya Nter heterocyclic yokhala ndi chomangira cha endocyclic.

Gliclazide MB imachepetsa shuga m'magazi ndikulimbikitsa chinsinsi cha insulin ndi β-maselo a islets a Langerhans. Pambuyo pa chithandizo cha zaka 2, odwala ambiri akadali ndi chiwopsezo cha postprandial insulin ndi secretion ya C-peptides.

Mtundu wachiwiri wa matenda a shuga, mankhwalawa amabwezeretsa chiyambi champhamvu cha insulin chifukwa cha kuchuluka kwa glucose ndikuwonjezera gawo lachiwiri la insulin secretion. Kuwonjezeka kwakukulu kwa insulin katulutsidwe kumawonedwa poyankha kukondoweza chifukwa cha zakudya zomwe amapatsa ndi shuga.

Gliclazide MV imakhudzanso ma microcirculation. Amachepetsa chiopsezo cha chotupa chama magazi (thrombosis) yam'magazi, kukhudza njira ziwiri zomwe zingakhudzidwe ndikupanga zovuta m'matenda a shuga: kusakanikirana kwakanthawi kwa kupatsidwa kwa zinthu za m'magazi komanso kutsekeka komanso kuchepa kwa kugwiritsidwa ntchito kwa zinthu zamagulu a cell (beta-thromboglobulin, thromboxane B2), komanso kubwezeretsa ntchito ya fibrinolytic mtima endothelium ndi kuchuluka kwa minofu plasminogen activator.

Zochita zamankhwala osokoneza bongo

Mankhwala omwe amalimbikitsa mphamvu ya Gliclazide MV (chiwopsezo chowonjezeka cha hypoglycemia)

Miconazole (akaperekedwa mwadongosolo kapena kugwiritsidwa ntchito kwa mucosa wamkati mwa mawonekedwe a gel): imakulitsa mphamvu ya hypoglycemic ya MV Gliclazide (hypoglycemia imatha kukhala mpaka hypoglycemic coma.

Zosavomerezeka kuti zigwiritsidwe:

Phenylbutazone imawonjezera mphamvu ya hypoglycemic ya zotumphukira za sulfonylurea (zimawachotsa kuti asalumikizane ndi mapuloteni a plasma komanso / kapena amachepetsa mayeso awo kuchokera mthupi).

Ndikofunika kugwiritsa ntchito mankhwala ena odana ndi kutupa.

Mowa umachulukitsa hypoglycemia, kupewetsa mphamvu zamagetsi, zimathandizira kukulitsa kukomoka kwa hypoglycemic.

Ndikofunikira kusiya kumwa mowa ndi kumwa mankhwala, monga mowa.

Kuphatikiza komwe kumafunikira kuchenjeza:

Kugwiritsa ntchito pamodzi mankhwala otsatirawa kungakulitse kuchuluka kwa mankhwala a Gliclazide MV ndipo nthawi zina kumayambitsa hypoglycemia:

othandizira ena odwala matenda a shuga (ma insulins, acarbose, biguanides), opanga ma beta, fluconazole, angiotensin-otembenuza enzyme inhibitors (Captopril, enalapril), H2 receptor antagonists, osasinthika a monoamine oxidase inhibitors (MAO I), sulfonamides ndi mankhwala osapweteka a antiidal.

Mankhwala ofooketsa a Glyclazide MV

Zosavomerezeka kuti zigwiritsidwe:

Kugwiritsa ntchito limodzi ndi danazol osavomerezeka chifukwa chakuwonjezeka kwa glucose wamagazi. Ngati nkosatheka kukana kugwiritsa ntchito danazol, fotokozerani wodwalayo kufunika kolamulira kuchuluka kwa shuga m'magazi ndi mkodzo. Nthawi zina pamafunika kusintha mlingo wa Gliclazide MV nthawi ya mankhwala a danazol kapena pambuyo pa danazol.

Kuphatikiza komwe kumafunikira kuchenjeza:

Chlorpromazine mu Mlingo wambiri (zoposa 100 mg patsiku) amawonjezera kuchuluka kwa shuga m'magazi, kuchepetsa kubisalira kwa insulin.

Glucocorticosteroids (ofunikira komanso am'deralo: intraarticular, khungu ndi rectal management) ndi tetracosactrin kuwonjezera magazi ndi kuthekera kwa ketoacidosis, chifukwa cha kuchepa kwa kulekerera kwa chakudya ndi glucocorticosteroids.

β2-adrenostimulants - ritodrin, salbutamol, terbutaline (kugwiritsa ntchito kwadongosolo) kumapangitsa kuchuluka kwa shuga.

Yang'anani makamaka pakufunika kwakudziyang'anira nokha shuga. Ngati ndi kotheka, sinthani wodwala kupita ku insulin.

Ngati mukufuna kugwiritsa ntchito mitunduyi pamwambapa, muyenera kuyang'anira kwambiri kuchuluka kwa shuga m'magazi. Pangakhale kofunikira kuwonjezera pakusintha kwa MV Glyclazide onse munthawi yophatikiza mankhwala atasiya kumwa mankhwala ena.

Kuphatikizika kwa Gliclazide MV ndi mankhwala opatsirana (warfarin, etc.) kungayambitse kuwonjezeka kwa anticoagulant ya mankhwalawa. Kusintha kwa mankhwalawa kwa anticoagulant kungafunike.

Zambiri

Satifiketi yakulembetsa ku Gliclazide MV imaperekedwa ndi kampani yaku Russia Atoll LLC. Mankhwala omwe ali pansi pa mgwirizano amapangidwa ndi kampani ya Samara yopanga mankhwala Ozone. Imapanga ndi kunyamula mapiritsi, ndikuwongolera mtundu wawo. Gliclazide MV silingatchulidwe ngati mankhwala apanyumba, popeza mankhwala omweyo (amagulitsanso glyclazide) amagulitsidwa ku China. Ngakhale izi, palibe cholakwika chomwe chinganenedwe za mtundu wa mankhwalawa. Malinga ndi odwala matenda ashuga, palibe vuto lililonse kuposa French Diabeteson yofananira.

Mawu achidule a MV m'dzina la mankhwalawa akuwonetsa kuti chinthu chomwe chimagwira mwa iye chimasinthidwa. Glyclazide imatuluka piritsi pa nthawi yoyenera komanso pamalo oyenera, yomwe imawonetsetsa kuti simalowa m'magazi nthawi yomweyo, koma m'magawo ang'onoang'ono. Chifukwa cha izi, chiwopsezo cha zotsatira zosafunikira chimachepetsedwa, mankhwalawa amatha kumwa pafupipafupi.Ngati mapangidwe a piritsi amaphwanyidwa, nthawi yake yayitali imatayika, motero, malangizo ogwiritsira ntchito silimbikitsa kuti azidula.

Glyclazide imaphatikizidwa pamndandanda wazamankhwala ofunikira, chifukwa chake ma endocrinologists ali ndi mwayi wopereka kwa odwala matenda ashuga kwaulere. Nthawi zambiri, malinga ndi zomwe wapatsidwa, ndi MV Gliclazide yomwe ndi analog ya Diabeteson woyambayo.

Kodi mankhwalawa amagwira ntchito bwanji?

Ma gliclazide onse atakhudzidwa m'mimba amatayikiridwa m'magazi ndipo amaphatikizana ndi mapuloteni ake. Nthawi zambiri, shuga amalowa m'maselo a beta ndipo amathandizira zolandilira zapadera zomwe zimapangitsa kutulutsidwa kwa insulin. Glyclazide imagwiranso ntchito mofananamo, kupangitsa mwachilengedwe kuphatikizika kwa mahomoni.

Zotsatira pakupanga insulin sizingokhala ndi zotsatira za MV Glyclazide. Mankhwala amatha:

1. Kuchepetsa kukana insulin. Zotsatira zabwino (kuchuluka kwa insulivivity mwa 35%) zimawonedwa.
2. Kuchepetsa kapangidwe ka shuga ndi chiwindi, potero kumapangitsa kusala kudya.
3. Pewani magazi kuundana.
4. Yambitsani kaphatikizidwe ka nitric oxide, yomwe imakhudzidwa pakukakamiza, kuchepetsa kutupa, komanso kukonza magazi kuti apange ziwalo zotumphukira.
5. Ntchito ngati antioxidant.

Kutulutsa mawonekedwe ndi mlingo

Piritsi Gliclazide MV ndi 30 kapena 60 mg yogwira ntchito. Zothandizira zothandizira ndi izi: cellulose, yomwe imagwiritsidwa ntchito ngati chochulukitsa, silika ndi magnesium stearate ngati emulsifiers. Mapiritsi amtundu woyera kapena kirimu, womwe umayikidwa mu matuza a 10-30 zidutswa. Mu paketi ya matuza a 2-3 (mapiritsi 30 kapena 60) ndi malangizo. Glyclazide MV 60 mg imatha kugawidwa pakati, chifukwa izi ndizowopsa pamapiritsi.

Mankhwalawa amayenera kuledzera pakudya cham'mawa. Gliclazide imagwira ntchito mosasamala kanthu za kupezeka kwa shuga m'magazi. Kuti hypoglycemia isachitike, palibe chakudya chomwe muyenera kudumpha, chilichonse chimayenera kukhala ndi chakudya chofanana. Ndikofunika kuti mudye mpaka katatu pa tsiku.

Malamulo akusankha:

Malangizo atsatanetsatane oti mugwiritse ntchito

Malinga ndi malingaliro azachipatala a Unduna wa Zaumoyo ku Russia, gliclazide iyenera kuyikidwa kuti ikulimbikitse insulin. Moyenerera, kusowa kwa mahomoni akeake kuyenera kutsimikiziridwa ndikuwunika wodwalayo. Malinga ndi ndemanga, izi sizimachitika nthawi zonse. Othandizira ndi ma endocrinologists amapereka mankhwala "ndi maso". Zotsatira zake, zochuluka kuposa kuchuluka kwa insulin komwe kumatulutsidwa, wodwalayo amafuna kudya nthawi zonse, kulemera kwake kukuwonjezeka pang'onopang'ono, ndipo kubwezeredwa kwa matenda ashuga sikokwanira. Kuphatikiza apo, maselo a beta okhala ndi njira yotereyi amawonongeka mwachangu, zomwe zikutanthauza kuti matendawo amapita gawo lina.

Mungapewe bwanji izi:

1. Yambani kutsatira zakudya za anthu odwala matenda ashuga (tebulo Na. 9, kuchuluka kwa chakudya kokhazikika kwa dokotala kapena wodwalayo malinga ndi glycemia).
2. Fotokozerani zochitika zatsiku ndi tsiku.
3. Kuchepetsa thupi kubwinobwino. Mafuta ochulukirapo amawonjezera shuga.
4. Imwani glucophage kapena mawonekedwe ake. Mulingo woyenera kwambiri ndi 2000 mg.

Ndipo pokhapokha ngati izi sizikwanira shuga wabwinobwino, mutha kuganiza za gliclazide. Musanayambe chithandizo, ndikofunikira kuyesedwa kwa C-peptide kapena insulin kuti muwonetsetse kuti kuphatikizika kwa mahomoni kumavulaza kwenikweni.

Ha glycated hemoglobin ndi yokwera kuposa 8.5%, MV Gliclazide imatha kuperekedwa limodzi ndi zakudya komanso metformin kwakanthawi, mpaka matenda a shuga amalipiridwe. Pambuyo pake, nkhani yosiya mankhwala imasankhidwa payekhapayekha.

Wogwirizira Sitifiketi Yoyang'anira

JLLC "Lekpharm", Republic of Belarus, 223141, Logoysk, ul. Minskaya, 2a, tel / fax: +375 1774 53 801, imelo: [email protected]

Adilesi ya bungweli kuvomereza zofunsidwa kwa ogula pamsika wazogulitsa zomwe zili mdera la Republic of Kazakhstan

Woimira ofesi ya Lekpharm COOO ku Republic of Kazakhstan,

050065, Republic of Kazakhstan, Almaty, dera la Almaly, ul. Kazybek bi, d. 68/70, ngodya ya st. Nauryzbay batyr, tel. 8 (727) -2676670, fakisi 8 (727) -2721178

Dzinalo, adilesi ndi zambiri zokhudzana ndi (foni, fakisi, imelo) ya bungwe lomwe lili kudera la Republic of Kazakhstan lomwe limayang'anira kuwongolera kwa chitetezo cha mankhwala

Woimira ofesi ya Lekpharm COOO ku Republic of Kazakhstan,

050065, Republic of Kazakhstan, Almaty, dera la Almaly, ul. Kazybek bi, d. 68/70, ngodya ya st. Nauryzbay batyr, tel. 8 (727) -2676670, fakisi 8 (727) -2721178,

Zotsatira za pharmacological

Zogulitsa ndi kugawa

Mutatha kumwa mankhwalawo mkati, gliclazide imatenga gawo lonse la m'mimba. Kuchulukana kwa gliclazide mu plasma kumawonjezeka pang'onopang'ono mkati mwa maola 6 atatha kukhazikitsa ndikufika kumapanga omwe akupitilira kuyambira 6 mpaka 12 ora. Kusiyanasiyana kwamunthu aliyense kumakhala kotsika. Kudya sizimakhudza kuchuluka kwa mayamwidwe. Voliyumu yogawa ndi pafupifupi malita 30. Plasma kumanga mapuloteni pafupifupi 95%. Mlingo umodzi tsiku lililonse wa mankhwala a Gliclada® umawonetsetsa kuti glyclazide yogwira plasma imaposa maola 24.

Gliclazide imapangidwa makamaka mu chiwindi. Zotsatira zake za metabolites zilibe zochitika za pharmacological. Kuyanjana kwa mlingo womwe umatengedwa mpaka 120 mg ndi kuchuluka kwa mankhwalawa m'madzi a plasma ndikodalira kwa nthawi.

Hafu ya moyo (T1 / 2) ya gliclazide ndi maola 12-20. Imafufutidwa makamaka ndi impso mu mawonekedwe a metabolites, ochepera 1% omwe amaponyedwa mkodzo osasinthika.

Pharmacokinetics mu milandu yapadera yamankhwala

Okalamba, palibe kusintha kwakufunika kwamapiritsi a pharmacokinetic komwe kwapezeka.

Gliclada ® ndi mankhwala osokoneza bongo a hypoglycemic ochokera ku gulu la sulfonylurea ofanana ndi a m'badwo wachiwiri, omwe amasiyana ndi mankhwala omwewo mwa kukhalapo kwa mphete ya Nter heterocyclic yokhala ndi chomangira cha endocyclic.

Glyclada® imatsitsa shuga m'magazi ndikulimbikitsa kuteteza kwa insulin ndi maselo a Langerhans okhala ndi maselo a R. Pambuyo pa zaka ziwiri zamankhwala, kuwonjezereka kwa kuchuluka kwa insulin ya postprandial ndi secretion ya C-peptides kumatsalira. Mtundu wachiwiri wa matenda a shuga, mankhwalawa amabwezeretsa chiyambi champhamvu cha insulin chifukwa cha kuchuluka kwa glucose ndikuwonjezera gawo lachiwiri la insulin secretion. Kuwonjezeka kwakukulu kwa insulin katulutsidwe kumawonedwa poyankha kukondoweza chifukwa cha zakudya zomwe amapatsa ndi shuga.

Kuphatikiza pa kukhudza kagayidwe kazachilengedwe, Glyclada® imathandizanso pakukula kwa ma cell. Mankhwala amachepetsa chiopsezo chaching'ono chotupa cha thrombosis, chikukhudza njira ziwiri zomwe zingakhudzidwe ndikupanga zovuta m'matenda a shuga: kusakanikirana kwakanthawi kwa kuphatikizana kwa mapulogalamu am'magazi komanso kutsika ndi kuchepa kwa kuchuluka kwa ma cell a activation (beta-thromboglobulin, thromboxane B2), komanso kubwezeretsa fibrinolytic mtima endothelial ntchito ndi kuchuluka kwa minofu plasminogen activator.

Momwe mungatengere panthawi yoyembekezera

Malangizo ogwiritsira ntchito kuletsa chithandizo ndi Gliclazide pa nthawi ya pakati ndi mkaka wa m`mawere. Malinga ndi gulu la FDA, mankhwalawa ndi a m'gulu la C. Izi zikutanthauza kuti zimatha kusokoneza kukula kwa mwana wosabadwayo, koma sizimayambitsa kusokonezeka kwa kubereka. Gliclazide ndiyotetezedwa m'malo ndi mankhwala a insulin musanabadwe, m'malo ovuta kwambiri - kumayambiriro.

Kuthekera kwa kuyamwitsa ndi gliclazide sikunayesedwe. Pali umboni kuti kukonzekera kwa sulfonylurea kumatha kulowa mkaka ndikuyambitsa hypoglycemia mwa makanda, kotero kugwiritsa ntchito panthawiyi ndizoletsedwa.

Doctor of Medical Science, Mutu wa Institute of Diabetesology - Tatyana Yakovleva

Ndakhala ndikuphunzira matenda a shuga kwa zaka zambiri. Zimakhala zowopsa anthu ambiri akamwalira, ndipo makamaka amakhala olumala chifukwa cha matenda ashuga.

Ndithamangira kunena mbiri yabwino - Endocrinological Research Center ya Russia Academy of Medical Science idatha kupanga mankhwala omwe amachiritsiratu matenda ashuga. Pakadali pano, kugwiritsa ntchito bwino kwa mankhwalawa kuyandikira 98%.

Nkhani ina yabwino: Unduna wa Zaumoyo wateteza kukhazikitsidwa kwa pulogalamu yapadera yomwe imalipira mtengo wa mankhwalawo. Ku Russia, odwala matenda ashuga mpaka Meyi 18 (kuphatikiza) nditha kuipeza - Kwa ma ruble 147 okha!

Zotsatira zoyipa ndi bongo

Zotsatira zoyipa kwambiri za MV Glyclazide ndi hypoglycemia. Zimachitika pamene kupanga kwa insulin kwadutsa kofunikira pakufunikira. Cholinga chake chimatha kukhala kuti mwangozi mankhwala osokoneza bongo, kudumphadumpha chakudya kapena kusowa kwa chakudya m'thupi, komanso kuchita masewera olimbitsa thupi mopitirira muyeso. Komanso, kutsika kwa shuga kungayambitse kuchuluka kwa gliclazide m'mwazi chifukwa cha kulephera kwaimpso ndi chiwindi, kuwonjezeka kwa ntchito ya insulin m'matenda ena a endocrine. Malinga ndi ndemanga, mankhwalawa sulfonylureas ndi hypoglycemia, pafupifupi onse odwala matenda ashuga. Madontho ambiri a shuga amatha kuthetseka mosavuta.

Monga lamulo, hypoglycemia imayendera limodzi ndi zizindikiro zosonyeza: njala yayikulu, kugwedezeka kwamphamvu, kukalamba, kufooka. Odwala ena pang'onopang'ono amasiya kumva izi, kutsika kwawo kwa shuga ndikuwopseza moyo. Amafuna kuwongolera pafupipafupi shuga, kuphatikiza usiku, kapena kusamukira kumapiritsi ena ochepetsa shuga omwe alibe zotsatira zoyipa.

Chiwopsezo cha zochita zina zosafunikira za Gliclazide zimayesedwa ngati zosowa komanso zosowa kwambiri. Chotheka:

• kugaya chakudya mu mawonekedwe a mseru, zovuta matumbo, kapena m'mimba. Mutha kuwathetsa potenga Glyclazide panthawi yazakudya kwambiri,
• zotupa za pakhungu, nthawi zambiri zimakhala ngati zotupa ndipo zimayamwa
• kutsika kwa mapulosi, maselo ofiira am'magazi, maselo oyera amwazi. Kapangidwe ka magazi kamabweranso kokhako pambuyo pakuchotsedwa kwa Gliclazide,
• kuwonjezeka kwakanthawi kwa ntchito ya chiwindi michere.

Yemwe Glyclazide MV wapatukana

Zitha kusintha

Gliclazide ya ku Russia ndiyotsika mtengo, koma m'malo mwake ndi mankhwala apamwamba kwambiri, mtengo wamatayala a Gliclazide MV (30 mg, 60 vipande) wafika mpaka ma ruble 150. M'malo mwake ndi analogues pokhapokha ngati mapiritsi wamba sogulitsidwa.

Mankhwala oyamba ndi Diabeteson MV, mankhwala ena onse omwe ali ndi mawonekedwe omwewo, kuphatikiza Gliclazide MV ndi majenito, kapena makope. Mtengo wa matenda ashuga ndiwotsika pafupifupi 2-3 kuposa ma genetic ake.

Glyclazide MV analogues ndi oloweza olembetsedwa ku Russian Federation (zosintha zakumasulidwa zokhazokha zikuwonetsedwa):

• Glyclazide-SZ yopangidwa ndi Severnaya Zvezda CJSC,
• Golda MV, Pharmasintez-Tyumen,
• Gliclazide Canon kuchokera ku Canonpharm Production,
• Glyclazide MV Malo ogulitsa, Pharmstandard-Tomskkhimfarm,
• Diabetalong, wopanga MS-Vita,
• Gliklada, Krka,
• Glidiab MV kuchokera ku Akrikhin,
• Diabefarm MV Pharmacor Production.

Mtengo wa analogues ndi ma ruble 120-150 pa phukusi lililonse. Gliklada yopangidwa ku Slovenia ndiye mankhwala okwera mtengo kwambiri kuchokera pamndandandawu, paketi imadya pafupifupi ma ruble 250.

Ndemanga Zahudwala

Ndinawerenga kuti Galvus imaperekanso chimodzimodzi, koma ndiyotetezeka kwambiri pankhani ya kuponya shuga. Ndifunsa adotolo kuti asinthane ndi Gliclazide.

Onetsetsani kuti mwaphunzira! Kodi mukuganiza kuti kuyamwa kwa mapiritsi ndi insulini kwa nthawi yonse yokhayo ndi njira yokhayo yosungira shuga m'manja? Sichowona! Mutha kutsimikizira izi nokha ndikuyamba kuzigwiritsa ntchito. werengani zambiri >>