Lisinopril Teva: malangizo, ntchito, maupangiri, wopanga, ndemanga

- ochepa matenda oopsa (mu monotherapy kapena kuphatikiza mankhwala ena a antihypertensive),

- Kulephera kwa mtima (monga njira yophatikiza),

- chithandizo choyambirira cha infarction yovuta kwambiri (m'maola 24 oyamba ndi hemodynamics yokhazikika kuti muzitha kuzitsatira ndikuletsa kukomoka kwamitsempha yamkati ndi mtima kulephera),

- diabetesic nephropathy (kutsitsa albinuria odwala omwe ali ndi vuto la matenda ashuga 1 ndi magazi othamanga, komanso kwa odwala omwe ali ndi matenda a shuga 2 omwe amakhala ndi matenda oopsa).

Contraindication

- Hypersensitivity to lisinopril, zida zina za mankhwala kapena zoletsa zina za ACE,

- Mbiri ya angioedema (kuphatikizapo kugwiritsa ntchito zoletsa zina za ACE),

- cholowa cha Quincke edema ndi / kapena idiopathic angioedema,

- zaka mpaka 18 (kuchita bwino ndi chitetezo sizinakhazikitsidwe),

- Mimba komanso nthawi yoyamwitsa.

Chenjerani: kumvekera kwa impso kwamitsempha kapena kukokoloka kwa minyewa imodzi ya impso yokhala ndi azotemia, mawonekedwe atatha kupatsirana kwa impso, kulephera kwa impso, hemodialysis pogwiritsa ntchito ziwalo zamkati (AN69R). Hypotension, matenda a cerebrovascular (kuphatikiza kuchepa kwa magazi m'thupi), matenda a mtima, kuchepa kwa mtima, matenda a autoimmune minofu yolumikizira (kuphatikiza ndi scleroderma, systemic lupus erythematosus), kuletsa kwamitsempha yama hematopoiesis, mikhalidwe yotsatana ndi kuchepa kwa magazi mozungulira magazi (BCC) (kuphatikiza kutsegula m'mimba, kusanza), kugwiritsa ntchito odwala pakudya koletsedwa mchere wa gome, odwala okalamba, munthawi yomweyo kugwiritsa ntchito potaziyamu, okodzetsa, mankhwala ena othandizira, NSAIDs, kukonzekera kwa lithiamu, maantacid, colestyramine, ethanol, insulin, kukonzekera kwina kwa hypoglycemic Tami, allopurinol, procainamide, kukonzekera golide, antipsychotics, tricyclic antidepressants, barbiturates, beta-blockers, calcium njira blockers pang'onopang'ono.

Momwe mungagwiritsire ntchito: Mlingo ndi njira ya chithandizo

Mankhwala Lisinopril-Teva amatengedwa pakamwa 1 nthawi / tsiku, mosasamala nthawi yakudya, makamaka nthawi yomweyo. Mlingo amasankhidwa payekha. Ndi ochepa matenda oopsa, odwala osalandira mankhwala ena a antihypertensive amagwiritsa 5 mg / tsiku. Palibe achire, mankhwalawa amachulukitsidwa masiku onse awiri ndi 2 mg mpaka 20 mg mg / tsiku (kuwonjezera mlingo wa 40 mg / tsiku nthawi zambiri sikuti kumabweretsa kuchepa kwa kuthamanga kwa magazi).

Pafupifupi tsiku lililonse yokonza 20 mg. Mlingo wambiri watsiku ndi tsiku ndi 40 mg. The achire zotsatira zambiri amakula pambuyo 2-4 milungu kuyambira chiyambi cha mankhwala, zomwe ziyenera kuganiziridwa pakukulitsa mlingo. Ndi osakwanira kwenikweni, kugwiritsa ntchito mankhwala munthawi yomweyo ndi mankhwala ena a antihypertensive ndikotheka.

Ngati wodwalayo adalandira chithandizo choyambirira ndi okodzetsa, ndiye kuti kumwa mankhwalawa kuyenera kuyimitsidwa masiku 2-3 asanayambe kugwiritsa ntchito mankhwalawa Lisinopril-Teva. Ngati izi sizingatheke, ndiye kuti mlingo woyambirira wa Lisinopril-Teva sayenera kupitirira 5 mg / tsiku. Pankhaniyi, mutatenga mlingo woyamba, kuyang'aniridwa kwa achipatala kumalimbikitsidwa kwa maola angapo (mphamvu yayitali imatheka pambuyo pafupifupi maola 6), chifukwa kuchepa kwakukulu kwa magazi kumatha kuchitika.

Zotsatira za pharmacological

ACE inhibitor, amachepetsa kupangika kwa angiotensin II kuchokera ku angiotensin I. Kuchepa kwa zomwe angiotensin II kumabweretsa kutsika kwachindunji kutulutsidwa kwa aldosterone. Amachepetsa kuchepa kwa bradykinin ndikuwonjezera kaphatikizidwe ka prostaglandins. Kuchepetsa kwathunthu zotumphukira mtima kukana (OPSS), kuthamanga kwa magazi, preload, kupanikizika m'mapapo m'mimba, kumapangitsa kuchuluka kwa magazi kwa miniti ndikuwonjezera kulolerana kwa mtima ndi odwala omwe ali ndi vuto la mtima. Imakulitsa mitsempha pamlingo wokulirapo kuposa mitsempha. Zotsatira zina zimadziwika chifukwa chowonekera mu renin-angiotensin-aldosterone system (RAAS). Pogwiritsa ntchito nthawi yayitali, hypertrophy ya myocardium ndi makhoma amitsempha ya mtundu wotsalira amachepa. Amasintha magazi kupita ku ischemic myocardium.

Lisinopril amachepetsa albinuria. Zilibe kukhudzanso kuchuluka kwa shuga wamagazi mwa odwala matenda a shuga ndipo sikuti zimawonjezera kuchuluka kwa hypoglycemia.

Zotsatira zoyipa

Kuchokera pamtima dongosolo: nthawi zambiri - kuchepa kwamphamvu kwa kuthamanga kwa magazi, kuchepa kwamitsempha yamagazi, kuchepa kwamatumbo - infarction, tachycardia, palpitations, matenda a Raynaud, kawirikawiri - bradycardia, tachycardia, kuchuluka kwazizindikiro za kuchepa kwa mtima, kuvulala kwa chifuwa.

Kuchokera pakati mantha dongosolo: Nthawi zambiri - chizungulire, kupweteka mutu, infrequent - kusinthasintha kwa mphamvu, paresthesia, kugona tulo, sitiroko, kawirikawiri - chisokonezo, asthenic syndrome, kupendekera mwamphamvu kwa minofu ya miyendo ndi milomo, kugona.

Pa mbali ya hematopoietic dongosolo ndi zamitsempha yamagazi dongosolo: kawirikawiri - kuchepa kwa hemoglobin, hematocrit, kawirikawiri - leukopenia, neutropenia, agranulocytosis, thrombocytenia, eosinophilia, erythropenia, hemolytic anemia, lymphadenopathy, autoimmune matenda.

Malangizo apadera

Nthawi zambiri, kutsika kwamphamvu kwa kuthamanga kwa magazi kumachitika ndi kuchepa kwa BCC komwe kumachitika ndi diuretic mankhwala, kuchepa kwa zomwe sodium chloride zimaperekedwa mu chakudya, dialysis, kutsekula m'mimba kapena kusanza. Moyang'aniridwa ndi dokotala, tikulimbikitsidwa kugwiritsa ntchito mankhwalawa Lisinopril-Teva odwala omwe ali ndi matenda amitsempha yamagazi, matenda osokoneza bongo, omwe kuchepa kwambiri kwa magazi kungayambitse kuphwanya kwa myocardial kapena stroko. Kugwiritsa ntchito mankhwala Lisinopril-Teva kungayambitse matenda aimpso, pachimake kukanika kwaimpso, komwe nthawi zambiri kumatha kusintha ngakhale mutagwiritsa ntchito mankhwalawa. Osakhalitsa ochepa hypotension si kuphwanya lamulo kuti mugwiritse ntchito mankhwalawa.

Pankhani ya stenosis ya aimpso mtsempha wamagazi (makamaka ndi stenosis kapena matenda a impso imodzi), komanso kufalikira kwa magazi kozungulira komwe kumachitika chifukwa cha hyponatremia ndi hypovolemia, kugwiritsa ntchito mankhwala Lisinopril-Teva kungayambitse vuto laimpso, Nthawi zambiri sichingasinthe pambuyo pakutha kwa mankhwalawo.

Kuchita

Mosamala, lisinopril iyenera kugwiritsidwa ntchito nthawi yomweyo ndi potaziyamu-spure diuretics (spironolactone, triamteren, amiloride, eplerenone), kukonzekera kwa potaziyamu, m'malo mwa mchere wokhala ndi potaziyamu, cyclosporine - chiopsezo cha hyperkalemia chikuwonjezeka, makamaka ndi vuto laimpso. Chifukwa chake, kuphatikiza uku kuyenera kugwiritsidwa ntchito pokhapokha ngati lingaliro la dokotala payekha likuwunikira ntchito ya seramu potaziyamu ndi impso. Pogwiritsa ntchito munthawi yomweyo ndi ma diuretics ndi mankhwala ena a antihypertensive, mphamvu ya antihypertensive imapangidwanso.

Pogwiritsa ntchito munthawi yomweyo ndi ma NSAIDs (kuphatikizapo kusankha ma cycloo oxygenase-2 (COX-2) zoletsa), acetylsalicylic acid pa mlingo wopitilira 3 g / tsiku, estrogens, komanso sympathomimetics, mphamvu ya antihypertensive ya lisinopril yafupika. NSAIDs, kuphatikiza COX-2, ndi ACE zoletsa kumaonjezera seramu potaziyamu ndipo imatha kufooketsa ntchito yaimpso. Izi nthawi zambiri zimatha kusintha. Lisinopril amachepetsa ma excretion a kukonzekera kwa lifiyamu, chifukwa chake, pogwiritsa ntchito munthawi yomweyo, kuwonjezereka kwa kuchuluka kwake m'magazi am'magazi kumachitika, zomwe zimatha kuwonjezera mwayi wopanga zovuta, chifukwa chake, kuyika kwa lithiamu mu seramu kuyenera kuyang'aniridwa pafupipafupi.

Pogwiritsa ntchito munthawi yomweyo maantacid ndi colestyramine, kuyamwa kwa lisinopril kuchokera m'mimba thirakiti kumachepetsedwa.

Mafunso, mayankho, ndemanga pa mankhwala Lisinopril-Teva

Zomwe zimaperekedwa zimakonzekera akatswiri azamankhwala komanso zamankhwala. Chidziwitso chokwanira chokhudza mankhwalawa chili m'malangizo omwe aphatikizidwa ndi wopanga. Palibe chidziwitso chomwe chatumizidwa patsamba lino kapena tsamba lililonse la tsamba lathu chomwe chingagwire ntchito ngati cholowa m'malo mwapadera kwa katswiri.

Kodi mankhwalawa amwedwa liti mosamala?

Monga lamulo, kugwiritsa ntchito mosamala "Lisinopril Teva" kukuwonekera mu milandu ili:

• Zowonongeka zamkati pamodzi ndi ziwongo zam'mimbamo zam'mimba zimayenda pang'onopang'ono ndi azotemia komanso motsutsana ndi maziko a chinthu pambuyo podziwikika kwa ziwalozo.
• Ndi hyperkalemia, stenosis mkamwa mwa msempha, matenda oopsa a mtima.
• Poyerekeza ndi maziko a hyperaldosteronism yoyamba, ochepa hypotension ndi matenda a cerebrovascular (kuphatikizapo kufooka kwa magazi muubongo).
• Pamaso pa matenda a mtima, coronary insufficiency, autoimmune zokhudza zonse matenda a zotumphukira zimakhala (kuphatikizapo scleroderma, systemic lupus erythematosus).
• Pankhani ya chopinga wa m'mafupa hematopoiesis.
• Ndi zakudya zochepa mchere.
• Poyerekeza ndi maziko a zochitika za hypovolemic chifukwa cha kutsegula m'mimba kapena kusanza.
• Mukalamba.

Malangizo ogwiritsira ntchito

Mapiritsi "Lisinopril Teva" amagwiritsidwa ntchito pakamwa kamodzi patsiku, m'mawa, mosasamala kanthu za kudya zakudya, makamaka nthawi imodzi. Pamaso pa ochepa matenda oopsa, odwala omwe salandila mankhwala ena a antihypertensive amasankhidwa mamiligalamu 5 kamodzi patsiku. Ngati palibe chochita, mulingo umakwera masiku atatu onse ndi mamiligalamu asanu kufikira ku achire wamba 40 mamiligalamu (kuwonjezeka kopitilira voliyumu iyi sikumabweretsa kuchepa kowonjezereka kwa kukakamiza). Kuchuluka kwachilendo kwa mankhwalawa ndi mamililita 20.

Zotsatira zonse, monga lamulo, zimayamba pambuyo pa milungu inayi kuyambira chiyambi cha mankhwala, zomwe zimayenera kuganiziridwa pakukweza kuchuluka kwa mankhwalawa. Poyerekeza ndi maziko osakwanira azaumoyo, kuphatikiza mankhwalawa ndi mankhwala ena a antihypertensive ndikotheka. Ngati wodwalayo adatengapo ma diuretics, ndiye kuti kugwiritsa ntchito ndikofunikira kuyimitsa masiku atatu isanayambe kugwiritsa ntchito "Lisinopril Teva." Ngati izi sizingatheke, ndiye kuti mulingo woyambira sayenera kupitirira mamiligalamu 5 patsiku. Pambuyo pa mlingo woyamba, tikulimbikitsidwa kuchita zowunika zamankhwala kwa maola angapo (mphamvu yayitali imatheka pambuyo pafupifupi theka la tsiku), chifukwa kuchepa kwamankhwala kumawonedwa.

Pamaso pa kukonzanso kwa matenda a renovascular kapena zina zokhala ndi ntchito yochulukirapo ya renin-aldosterone, ndikofunikira kuperekanso mlingo woyambirira wa mamiligalamu 5 motsogozedwa ndi dokotala. Kuchulukitsa kwa mankhwalawa kuyenera kutsimikiziridwa kutengera mphamvu zake.

Poyerekeza ndi maziko a kuthamanga kwa matenda oopsa, chithandizo chokonza nthawi yayitali chikusonyezedwa mamiligalamu 15 a mankhwala patsiku. Kulephera kwa mtima kosatha, amayamba kumwa 2,5 ndikuwonjezeka pang'onopang'ono patatha masiku asanu mpaka mamiliyoni 5 kapena 10. Mulingo wambiri watsiku ndi tsiku mamilimita 20.

Mu pachimake myocardial infarction (monga gawo la mankhwala osakanikirana), ma milligram asanu amamwa tsiku loyamba, ndiye kuchuluka pambuyo pa maola makumi awiri ndi anayi ndipo 10 atatha masiku awiri. Kenako tengani ma milligram 10 kamodzi patsiku. Njira yochiritsira imatha milungu isanu ndi umodzi. Zikakhala kuti kupanikizika kwanthawi yayitali, chithandizo chokwanira ndi mankhwalawo chikuyenera kuyimitsidwa.

Poyerekeza ndi maziko a nephropathy odwala omwe ali ndi matenda a shuga a 2, ma milligram 10 amagwiritsidwa ntchito kamodzi patsiku. Ngati ndi kotheka, mulingo ungathe kuwonjezeka mpaka 20 kuti mukwaniritse kuchuluka kwa mapiritsi a diastoli osakwana 75 millimeter of mercury mukakhala pansi. Kwa odwala omwe ali ndi matenda a shuga 1, kuchuluka kwa mankhwalawa ndi chimodzimodzi.

Bongo

Zizindikiro za mankhwala osokoneza bongo ndi kuchepa kwa kupanikizika pamodzi ndi kuwuma pamlomo, kutsekemera kwamadzi yamagetsi, kupumira kwambiri ndi tachycardia. Izi zimatsimikiziridwa ndi malangizo ogwiritsa ntchito ndi kuwunika. "Lisinopril Teva" imatha kupangitsa kuti uzimva kupweteka palimodzi ndi bradycardia, chizungulire, kuda nkhawa, kusokonezeka, kugona, kwamikodzo posungika, kudzimbidwa, kugwa, mapira.

Chithandizo chidzafunika mu mawonekedwe a chapamimba cha m'mimba, kugwiritsa ntchito ma enterosorbents ndi mankhwala othandizira. Intravenous sodium mankhwala enaake amawonetsedwa. Zimafunikanso kuwongolera kupanikizika komanso malire a electrolyte. Hemodialysis ikuyenda bwino.

Mtengo wa mankhwalawa mu mulingo wa 10 mg pakali pano ndi ma ruble 116. Zimatengera dera komanso maukonde opangira mankhwala.

Mndandanda wa "Lisinopril Teva"

Magulu a mankhwala omwe afunsidwa ndi a Diroton, Irume, ndi Lysinoton. Ndikofunikira kumvetsetsa kuti ndi dokotala yekha yemwe ayenera kupereka mankhwala ena aliwonse m'malo mwa omwe amatifotokozera.

M'mawu awo, anthu amati "Lisinopril Teva" ndi njira yabwino yothanirana ndi matenda oopsa. Amadziwika kuti ndioyenera kukhala ndi monotherapy, komanso kuphatikiza ndi mankhwala ena a antihypertensive.

Kuphatikiza pa kuthana ndi kuthamanga kwa magazi, mankhwalawa amathandizanso odwala omwe ali ndi vuto la mtima, komanso monga mbali yoyambirira yamatenda a mtima.

Mukawunika "Lisinopril Teva" pali zodandaula za zoyipa mwanjira yowonjezera thukuta ndi mawonekedwe a zotupa pakhungu. Koma apo ayi, mankhwalawa amakondedwa ndi ogula chifukwa chogwira ntchito komanso mtengo wotsika mtengo.

Mlingo

5 mg, 10 mg, 20 mg mapiritsi

Piritsi limodzi lili

yogwira mankhwala ndi lisinopril dihydrate 5.44 mg, 10,89 mg kapena 21.78 mg, wofanana ndi lisinopril anhydrous 5 mg, 10 mg, 20 mg,

zotuluka: mannitol, calcium hydrogen phosphate dihydrate, pregelatinized wowuma, utoto PB-24823, croscarmellose sodium, magnesium stearate.

Mapiritsiwo ndi oyera, ozungulira, a biconvex, omwe ali ndi notch mbali imodzi (mlingo wa 5 mg).

Mapiritsiwo ndi opepuka pinki mumtundu, mozungulira, biconvex, ndi chiopsezo mbali imodzi (kwa 10 mg).

Mapiritsiwo ndi pinki, ozungulira, a biconvex okhala ndi notch mbali imodzi (kwa 20 mg).

Mankhwala

Kwambiri ndende ya madzi am`magazi amafikira pafupifupi maola 7 pambuyo pakamwa. Kudya sizimakhudza kuchuluka kwa mayamwidwe a lisinopril. Lisinopril samangiriza mapuloteni a plasma. The odzipereka biologic yogwira thunthu kwathunthu ndipo sanasinthe amasintha kudzera impso. Hafu ya moyo wawo inali maola 12.6. Lisinopril amawoloka placenta.

Lisinopril-Teva ndi choletsa wa angiotensin-kutembenuza enzyme (ACE inhibitor). Kuponderezedwa kwa ACE kumabweretsa kupendekera kwapadera kwa angiotensin II (ndi vasoconstrictor zotsatira) ndikuchepa kwa secretion ya aldosterone. Lisinopril-Teva amaletsanso kuwonongeka kwa bradykinin, peptide yamphamvu ya vasodepressor.Zotsatira zake, amachepetsa kuthamanga kwa magazi, kupuma kwathunthu kwamitsempha, kukweza komanso kutsitsa pamtima, kumawonjezera kuchuluka kwa miniti, kutulutsa kwamtima komanso kumawonjezera kulolerana kwa myocardial ndi katundu ndikupangitsa magazi kukhala okongola kwa ischemic myocardium. Odwala omwe ali ndi vuto lalikulu lodana ndi infracation, Lisinopril-Teva, pamodzi ndi nitrate, amachepetsa mapangidwe amanzere amitsempha yama mtima kapena mtima.

- Matenda a mtima osachiritsika (monga gawo la zovuta mankhwala okodzetsa ndi mtima wama glycosides)

- pachimake myocardial infaration kwa odwala okhazikika hemodynamics popanda zizindikiro aimpso kukanika.

Mlingo ndi makonzedwe

Kuchiza kuyenera kuyamba ndi 5 mg tsiku lililonse m'mawa. Mlingo uyenera kukhazikitsidwa m'njira yoti athe kupereka magazi moyenera. Nthawi yotalikirana pakati pa kuchuluka kwa mlingo iyenera kukhala milungu itatu. Mulingo woyenera wokonza ndi 10-20 mg wa lisinopril 1 nthawi patsiku, ndipo pazipita tsiku lililonse ndi 40 mg 1 nthawi patsiku.

Lisinopril-Teva adapangidwira kuwonjezera pa chithandizo chomwe chilipo ndi diuretics ndi digitalis. Mlingo woyamba ndi 2,5 mamawa. Mankhwala okonza ayenera kukhazikitsidwa m'magawo ndi kuwonjezeka kwa 2,5 mg ndi nthawi ya masabata a 2-4. Mulingo woyenera wokonza ndi 520 mg kamodzi tsiku lililonse. Osapitilira muyeso waukulu wa 35 mg wa lisinopril / tsiku.

Pachimake m`mnyewa wamtima infaration odwala khola hemodynamics:

Kuchiza ndi lisinopril-Teva kumatha kuyamba patadutsa maola 24 kutangoyamba kumene kwa zizindikiro, kupatsidwa magazi okhazikika a hemodynamics (systolic magazi ochulukirapo kuposa 100 mmHg, popanda chizindikiro cha kuperewera kwaimpso), kuwonjezera pa chithandizo chokwanira cha matenda a mtima (othandizira a thrombolytic, acetylsalicylic acid, beta-blockers, nitrate). Mlingo woyambirira ndi 5 mg, pambuyo pa maola 24 - wina 5 mg, pambuyo maola 48 - 10 mg. Ndiye kuti mlingo ndi 10 mg wa lisinopril 1 nthawi patsiku.

Odwala omwe ali ndi vuto lochepa kwambiri la systolic (≤ 120 mm Hg) musanalandire chithandizo kapena masiku atatu oyamba atakumana ndi vuto la mtima ayenera kulandira chithandizo chochepa cha 2,5 mg wa Lisinopril-Teva. Ngati kupanikizika kwa systolic kumakhala kochepera 90 mm Hg. Art. kupitirira ola limodzi ayenera kusiyidwa lisinopril-Teva.

Kuchiza kuyenera kupitilizidwa kwa milungu 6. Mlingo wocheperako wokonza ndi 5 mg patsiku. Odwala omwe ali ndi vuto la kulephera kwa mtima ayenera kupitiliza kuthandizidwa ndi lisinopril-Teva. Mankhwalawa amatha kuperekedwa nthawi yomweyo ndi nitroglycerin (kudzera m'mitsempha kapena mawonekedwe amkhungu).

Pankhani ya kulowetsedwa kwa myocardial, lisinopril iyenera kuperekedwa kuwonjezera pazomwe zimagwiritsidwa ntchito masiku onse (ma thrombolytic othandizira, acetylsalicylic acid, beta-blockers), makamaka pamodzi ndi nitrate.

Mwa odwala okalamba, mlingo uyenera kusinthidwa poganizira kuchuluka kwa creatinine (kuwunika ntchito ya impso), yomwe imawerengeredwa ndi njira ya Cockroft:

(140 - zaka) × kulemera kwa thupi (kg)

0,814 × seramu creatinine ndende (μmol / L)

(Kwa akazi, zomwe zimapezeka ndi formula izi ziyenera kuchulukitsidwa ndi 0.85).

Mlingo wa odwala omwe ali ndi zochepa aimpso ntchito (creatinine chilolezo 30 - 70 ml / min):

Mlingo woyambirira ndi 2.5 mg m'mawa, mlingo wokonza ndi 5-10 mg patsiku. Osapitilira muyeso wa 20 mg wa lisinopril patsiku.

Lisinopril-Teva amatha kumwedwa mosasamala zakudya, koma ndi madzi okwanira, 1 nthawi patsiku, makamaka nthawi imodzi.

Zochita zamankhwala osokoneza bongo

Pogwiritsa ntchito nthawi yomweyo mapiritsi a Lisinopril-Teva ndi:

- lifiyamu itha kuchepetsedwa lifiyamu kuchokera m'thupi, chifukwa chake, ndikofunikira kuyang'anira kusamala kwa ndende ya lithiamu mu seramu yamagazi

- analgesics, mankhwala osokoneza bongo a anti-yotupa (mwachitsanzo, acetylsalicylic acid, indomethacin) - ndizotheka kufooketsa mphamvu ya hypotensive ya lisinopril

- baclofen - ndikotheka kupititsa patsogolo hypotensive zotsatira za lisinopril-okodzetsa - ndizotheka kuwonjezera kuchuluka kwa hypotensive kwa lisinopril

- potaziyamu woteteza okodzetsa (spironolactone, triamteren kapena amiloride) ndi potaziyamu zowonjezera zimawonjezera chiopsezo cha hyperkalemia

- mankhwala a antihypertensive - angalimbikitse kuyipa kwamphamvu kwa lisinopril

- mankhwala oletsa kupweteka, mankhwala osokoneza bongo, mapiritsi ogona - mwina kuchepa kwambiri kwa magazi

- allopurinol, cytostatics, immunosuppressants, systemic corticosteroids, procainamide - chiopsezo chotenga leukopenia chikuwonjezeka

- mankhwala akumwa a antiidiabetesic (sulfonylurea derivatives, biguanides) ndi insulin - ndizotheka kuonjezera mphamvu ya hypotensive, makamaka masabata oyamba ophatikizira mankhwala.

- amifostine - hypotensive zotsatira zitha kupitilizidwa

- maantacid - - kuchepa kwa bioavailability wa lisinopril

- sympathomimetics - hypotensive zotsatira zitha kupititsidwa patsogolo

- mowa - mwina kuledzera

- sodium chloride - kufooka kwa hypotensive zotsatira za lisinopril ndi mawonekedwe a kulephera kwa mtima.

Kutulutsa Fomu

Mankhwalawa ali ngati mapiritsi. Mosasamala kanthu za kupsinjika, amapezeka mu mawonekedwe a oval biconvex ndi mtundu woyera. Pali chiopsezo mbali imodzi ya mapilitsi, mbali inayo ndikulemba "LSN2.5 (5, 10, 20)".

Zinthu za kukhazikitsidwa zimadalira ndende ya yogwira mankhwala. Mosasamala kanthu za izi, mapiritsiwo amaikidwa m'matumba a blister a zidutswa 10. Pa mlingo wa 2,5 mg, mbale zitatu zoterezi zimayikidwa phukusi limodzi, 5 mg - 1 kapena 3 zidutswa. Mapiritsi a 10 ndi 20 mg amagulitsidwa 1, 2 kapena 3 matuza pa paketi iliyonse.

Zochita zamankhwala

Lisinopril amaletsa enzyme yotembenuza-angiotensin, yomwe imathandiza kwambiri pakusokonekera kwa angiotensin I kupita ku angiotensin II. Zotsatira zake, kaphatikizidwe ka aldosterone ndi zotumphukira zamitsempha zimachepetsedwa, ndipo kupanga kwa prostaglandin kumawonjezeka. Izi zimabweretsa kutsika kwa kuthamanga kwa magazi, kuthamanga kwa mapangidwe am'mapapo ndi kutsitsa, kuwonjezeka kwa kuchuluka kwa magazi.

Kumwa mankhwalawa kumathandizira kuti magazi azikhala ndi minofu ya mtima. Kuchiza kwakanthawi kwakanthawi kumatha kuchepetsa myocardial hypertrophy. Odwala omwe ali ndi matenda a mtima osalephera, chiyembekezo chamoyo chimawonjezeka. Ngati vuto la mtima lidakomoka, koma kulephera kwa mtima sikuwonekeranso, ndiye kugwiritsa ntchito mankhwalawa, kumanzere kwamitsempha yamanzere kumayenda pang'onopang'ono.

M'masiku oyamba a mankhwalawa, zotsatira zake zamankhwala zimadziwika. Imafika pokhazikika mkati mwa miyezi 1-2 yokhazikika ya mankhwalawa.

Tiyenera kudziwa kuti ma pathologies ena amatha kusokoneza mankhwala a pharmacokinetic:

• kuchepa chilolezo, mayamwidwe ndi bioavailability (16%) pamaso pa mtima kulephera,
• kuchuluka nthawi zina kuchuluka kwa lisinopril mu plasma ndi aimpso kulephera.
• 2 kuchuluka kwambiri plasma ndende mu ukalamba,
• 30% kuchepa kwa bioavailability ndi 50% chilolezo cha matenda enaake.

Zotsatira zoyipa, bongo

Zotsatira zoyipa mukamatenga Lisinopril-Teva amagawika m'magulu molingana ndi mawonetsedwe. Nthawi zambiri, chithandizo choterechi chimabweretsa zotsatirazi:

• orthostatic hypotension,
• kutchulidwa kuchepa kwa kupsinjika,
• chizungulire, kupweteka mutu,
• kutsokomola
• kusanza
• kutsegula m'mimba
• matenda aimpso.

Mlingo uyenera kusankhidwa ndi katswiri. Pankhani ya mlingo wosankhidwa molakwika kapena kupitirira kuchuluka kwake, zotsatira zoyipa ndizotheka.

Nthawi zambiri, bongo wambiri umawonetsedwa ndi zizindikiro zotsatirazi:

• kuponya kwakukulu
• kamwa yowuma
• kusowa kwa madzi m'magetsi,
• kulephera kwa aimpso
• kupumira msanga
• palpitations
• chizungulire
• nkhawa
• kuchuluka kukwiya
• kugona
• bradycardia
• kutsokomola
• kusungika kwamikodzo
• kudzimbidwa
• Hyperventilation yamapapo.

Palibe mankhwala enieni a mankhwalawa. Ndikofunikira kutsuka m'mimba, kuonetsetsa kuti kudya kwa enterosorbent ndi mankhwala ofewetsa tuvi tolimba. Therapy imaphatikizanso kulowetsedwa kwamchere kwa saline. Ngati bradycardia ikana mankhwala, pitani kukhazikitsa pacemaker yochita kupanga. Gwiritsani ntchito hemodialysis bwino.

Kugwirizana kwina ndi mankhwala ena, mowa

N`kutheka kuti zochita za lisinopril zimatheka pamodzi ndi munthawi yomweyo diuretic mankhwala kapena makonzedwe ena a antihypertensive mankhwala. Ma Vasodilators, ma barbiturates, antidepressants, calcium antagonists, β-blockers angayambitse zotsatira zofananira. Zotsatira zotsutsana zimawonedwa ndikuphatikizidwa ndi acetylsalicylic acid, sympathomimetics, estrogens kapena mankhwala osokoneza bongo omwe si a antiidal.

Kukhazikitsidwa kwa munthawi yomweyo kwa Lisinopril-Teva komanso okodzetsa a gulu lokhala ndi potaziyamu kapena kukonzekera kwa potaziyamu kungayambitse matenda oopsa. Kuphatikizana ndi insulin kapena wothandizira wa hypoglycemic kungayambitse hyperglycemia.

Mowa kapena mankhwala omwe amakhala ndi ethanol amalimbikitsa mphamvu ya lisinopril.

Moyo wa alumali, malo osungira

Kusungidwa kwa mankhwalawa kuyenera kuchitika m'malo osafikirika kwa ana pa kutentha kosaposa 25 digiri. Ngati izi zakwaniritsidwa, mankhwalawa angagwiritsidwe ntchito mkati mwa zaka ziwiri kuyambira tsiku lomwe adapanga.

Mtengo wapakati pa Lisinopril-Teva 2,5 mg kapena 5 mg ndi ma ruble a 125. Mankhwalawa 10 mg amatenga pafupifupi ma ruble a 120 pazidutswa 20 ndi ma ruble 135 mwa zidutswa 30. Mankhwala a 20 mg angagule pafupifupi ma ruble 150 kwa mapiritsi 20 ndi ma ruble 190 a mapiritsi 30.

Kuti mugule, muyenera kupatsa wogulitsa zamankhwala mankhwala kuchokera kwa dokotala.

Lisinopril-Teva ali ndi ma fanizo ambiri. Zonsezi zimakhazikika pa chinthu chimodzi chogwira - lisinopril. Mankhwalawa akuphatikizapo:

• Aurolyza,
• Diroton
• Wophunzitsidwa
• Vitopril,
• Lysoryl
• Lizi Sandoz,
• Zonixem
• Lysinokol
• Lisopril
• Dapril
• Lysigamm
• Scopril
• Anayesa
• Lisighexal
• Solipril
• Linotor.

Lisinopril-Teva amaletsa enzyme yotembenuka ya angiotensin, ndikupereka zovuta. Tengani mankhwalawa amayenera kufotokozedwa ndi dokotala mosamala muyeso womwe unenedwa, apo ayi bongo ndi lotheka. Akaphatikizidwa ndi mankhwala ena, mphamvu ya zotsatira za lisinopril imatha kusiyanasiyana.

Njira ndi mawonekedwe

Mankhwala Lisinopril-Teva amagwiritsidwa ntchito pomeza kuchuluka kwa mapiritsi okhala ndi madzi okwanira. Mlingo wa tsiku ndi tsiku ndi wofanana piritsi limodzi, lomwe limayenera kudya nthawi yonse ya mankhwala kamodzi patsiku komanso nthawi yomweyo, osaganizira zakudya. Mlingo wa wodwala aliyense umasankhidwa ndi dokotala yekha.