Kodi Mungatenge Bwanji ndi Gwero la Galvus, Mankhwala A shuga

Galvus ndi mankhwala a matenda ashuga, omwe amagwira ntchito ndi vildagliptin, ochokera ku gulu la DPP-4 zoletsa. Mapiritsi a shuga a Galvus adalembedwa ku Russia kuyambira 2009. Amapangidwa ndi Novartis Pharma (Switzerland).

Mapiritsi a Galvus a shuga kuchokera ku gulu la zoletsa za DPP-4 - yogwira mankhwala Vildagliptin

Galvus adalembedwa kuti athandize odwala omwe ali ndi matenda ashuga a 2. Itha kugwiritsidwa ntchito ngati mankhwala okhawo, ndipo zotsatira zake zimakwaniritsa zotsatira za zakudya komanso masewera olimbitsa thupi. Mapiritsi a shuga a Galvus akhoza kugwiritsidwanso ntchito limodzi:

• metformin (siofor, glucophage),
• zotumphukira za sulfonylurea (palibe chifukwa chochita izi!),
• khalimon,
• insulin

Mlingo wa mapiritsi a Galvus

Mlingo wofanana ndi wa Galvus monga monotherapy kapena molumikizana ndi metformin, thiazolinediones kapena insulin - 2 pa tsiku, 50 mg, m'mawa ndi madzulo, mosasamala kanthu za kudya. Ngati wodwala amupatsa mlingo wa piritsi 1 la 50 mg patsiku, ndiye kuti ayenera kumwedwa.

Vildagliptin - zomwe zimagwiritsidwa ntchito popanga matenda a shuga a Galvus - zimapukusidwa ndi impso, koma mawonekedwe a metabolites osagwira. Chifukwa chake, pakuyamba kwa kulephera kwa impso, mlingo wa mankhwalawa suyenera kusinthidwa.

Ngati pali kuphwanya kwamphamvu kwa chiwindi ntchito (ALT kapena AST michere pafupipafupi 2.5 kuposa malire apamwamba), ndiye kuti Galvus iyenera kuyikidwa mosamala. Wodwala akayamba jaundice kapena zodandaula zina za chiwindi zimawonekera, chithandizo cha vildagliptin chiyenera kuyimitsidwa nthawi yomweyo.

Kwa odwala matenda ashuga azaka 65 ndi kupitilira - muyeso wa Galvus sukusintha ngati kulibe matenda ophatikizika. Palibe chidziwitso pakugwiritsa ntchito mankhwalawa kwa ana ndi achinyamata ochepera zaka 18. Chifukwa chake, sikulimbikitsidwa kuti mupereke kwa odwala a m'badwo uno.

Kuchepetsa shuga kwa vildagliptin

Mphamvu yotsitsa shuga ya vildagliptin idaphunziridwa pagulu la odwala 354. Zinapezeka kuti galvus monotherapy mkati mwa masabata 24 zinapangitsa kutsika kwakukulu kwa shuga m'magazi omwe sanalandire mtundu wawo wa 2 shuga. Mndandanda wawo wa hemoglobin wa glycated watsika ndi 0.4-0.8%, ndipo pagulu la placebo - mwa 0,1%.

Kafukufuku wina anayerekezera zotsatira za vildagliptin ndi metformin, mankhwala odziwika bwino a shuga (siofor, glucophage). Kufufuzaku kunakhudzanso odwala omwe anali atapezeka kuti anali ndi matenda a shuga 2, ndipo anali asanalandiridwepo.

Zidadziwika kuti galvus muzowonetsa zambiri zomwe sizigwira ntchito si zonyozeka kuposa metformin. Pambuyo pa masabata 52 (chaka chimodzi cha chithandizo) mwa odwala omwe akutenga galvus, kuchuluka kwa hemoglobin ya glycated kunatsika ndi pafupifupi 1.0%. Mu gulu la metformin, adatsika ndi 1.4%. Pambuyo pa zaka ziwiri, manambala adakhalabe omwewo.

Pambuyo pa masabata 52 atamwa mapiritsiwo, zidapezeka kuti mphamvu zamagulu olimbitsa thupi mwa odwala omwe ali m'magulu a vildagliptin ndi metformin ali ofanana.

Galvus imalekeredwa bwino ndi odwala kuposa metformin (Siofor). Zotsatira zoyipa zam'mimba zimayambira pafupipafupi. Chifukwa chake, ma algorithms amakono omwe akuvomerezedwa ndi boma la Russia pakuchizira matenda amtundu wa 2 amakulolani kuti muyambe kulandira chithandizo ndi galvus, pamodzi ndi metformin.

Galvus Met: vildagliptin + kuphatikiza kwa metformin

Galvus Met ndi mankhwala ophatikiza okhala ndi piritsi limodzi la vildagliptin pa 50 mg ndi metformin pa Mlingo wa 500, 850 kapena 1000 mg. Kulembetsa ku Russia mu Marichi 2009. Ndi bwino kulembera odwala piritsi 1 kawiri pa tsiku.

Galvus Met ndi mankhwala ophatikiza matenda a shuga a 2. Muli vildagliptin ndi metformin. Zida ziwiri zogwira piritsi limodzi - zosavuta kugwiritsa ntchito komanso zothandiza.

Kuphatikizidwa kwa vildagliptin ndi metformin kumawoneka koyenera pochiza matenda amtundu wa 2 odwala omwe samamwa metformin okha. Ubwino wake:

• mphamvu yotsitsa shuga m'magazi imachulukitsidwa, poyerekeza ndi monotherapy ndi mankhwala aliwonse,
• ntchito yotsalira ya maselo a beta pakupanga insulin imasungidwa,
• Kulemera kwa odwala sikukula,
• chiopsezo cha hypoglycemia, kuphatikiza kwambiri, sichikukula,
• pafupipafupi mavuto a metformin kuchokera m'matumbo am'mimba - amakhalabe ali pamodzimodzi, sawonjezeka.

Kafukufuku watsimikizira kuti kutenga Galvus Met ndikothandiza kwambiri ngati mutenga mapiritsi awiri osiyana ndi metformin ndi vildagliptin. Koma ngati mukufuna kumwa piritsi limodzi lokha, ndiye kuti ndi losavuta kwambiri ndipo mankhwalawo ndi othandiza kwambiri. Chifukwa sizochepa kuti wodwalayo aiwale kapena kusokoneza china chake.

Wachita kafukufuku - ndikufanizira chithandizo cha matenda ashuga ndi Galvus Met ndi chiwembu china chodziwika bwino: metformin + sulfonylureas. Sulfonylureas adalembedwera odwala omwe ali ndi shuga omwe adapeza Metformin yekha sikokwanira.

Phunziroli linali lalikulu. Oposa 1300 odwala m'magulu onse awiri adatenga nawo mbali. Kutalika - 1 chaka. Zinapezeka kuti odwala omwe akutenga vildagliptin (50 mg 2 kawiri pa tsiku) ndi metformin, kuchuluka kwa shuga m'magazi kunatsikanso komanso iwo omwe amatenga glimepiride (6 mg 1 nthawi patsiku).

Panalibe kusiyana kwakukulu pazotsatira zakuchepetsa shuga. Nthawi yomweyo, odwala omwe ali mgulu la mankhwala a Galvus Met adakumana ndi hypoglycemia nthawi 10 kochepa poyerekeza ndi omwe amachitidwa ndi glimepiride ndi metformin. Panalibe milandu ya hypoglycemia yayikulu kwa odwala omwe amatenga Galvus Met kwa chaka chonse.

Momwe Mapiritsi A shuga a Galvus Amagwiritsidwira Ntchito ndi Insulin

Galvus anali woyamba mankhwala a shuga ochokera ku gulu la DPP-4 inhibitor, lomwe adalembetsa kuti azigwiritsa ntchito limodzi ndi insulin. Monga lamulo, limayikidwa ngati sizingatheke kuyendetsa matenda a shuga a 2 limodzi ndi mankhwala oyambira okha, ndiye kuti insulin.

Kafukufuku wa 2007 adayesa kuyendetsa bwino ndiku chitetezo cha kuwonjezera galvus (50 mg 2 kawiri patsiku) motsutsana ndi placebo. Odwala adatenga nawo gawo omwe adakhazikika pamatumbo a glycated hemoglobin (7.5-11%) pokana jakisoni wa "pafupifupi" insulini yokhala ndi gawo la Hagedorn protramine (NPH) pamitengo yoposa 30 mayunitsi / tsiku.

Odwala 144 adalandira galvus limodzi ndi jakisoni wa insulin, odwala 152 omwe ali ndi matenda a shuga a 2 adalandira placebo kumbuyo kwa jakisoni wa insulin. Mu gulu la vildagliptin, kuchuluka kwa hemoglobin wa glycated kwambiri kumatsika ndi 0,5%. Mu gulu la placebo, ndi 0,2%. Mwa odwala omwe ali ndi zaka zopitilira 65, Zizindikiro ndizabwino koposa - kutsika kwa 0.7% kumbuyo kwa galvus ndi 0,1% chifukwa chotenga placebo.

Pambuyo powonjezera galvus ndi insulin, chiopsezo cha hypoglycemia chinachepa kwambiri, poyerekeza ndi mankhwala a shuga, jakisoni wa "sing'anga" NPH-insulin. Mu gulu la vildagliptin, chiwerengero chonse cha hypoglycemia chinali 113, m'gulu la placebo - 185. Komanso, palibe vuto limodzi la hypoglycemia lomwe lidadziwika motsutsana ndi maziko a chithandizo cha vildagliptin. Panali zochitika 6 zotere mu gulu la placebo.

The zikuchokera ndi zimatha mapiritsi

Zomwe zili mkati mwa mapiritsi ndi izi zigawo:

• gawo lalikulu ndi vildagliptin,
• othandizira zigawo - cellulose, lactose, sodium carboxymethyl wowuma, magnesium stearate.

Mankhwalawa ali ndi izi katundu:

• Amasintha ntchito zapantchito,
• zimayambitsa kuchepa kwa insulin chifukwa cha kusintha kwa ntchito za maselo apakhungu owononga,
• amachepetsa kuchuluka kwa lipids yoyipa m'magazi.

Zokhudza thupi

Mankhwalawa amathandizira thupi la wodwalayo. Nthawi zina, zotsatira zoyipa zimawonedwa. Mankhwala amakulolani kusintha shuga m'magazi chifukwa cha kapangidwe kake ndi katundu wake. Imawonjezera ntchito ya kapamba ndi ma enzymes omwe amathandizira kukoka kwa glucose.

Mankhwalawa amasintha wodwala ndipo zotsatira zake zimapitirira kwa nthawi yayitali. Zotsatira za mankhwalawa ndi maola 24.

Kuchoka kwa mankhwalawa kumachitika makamaka mothandizidwa ndi impso, kawirikawiri kudzera m'matumbo.

Momwe mungagwiritsire ntchito?

Mankhwala "Galvus" akuwonetsedwa ngati matenda amitundu iwiri. Mankhwalawa amamwa kumwa piritsi limodzi m'mawa uliwonse, kapena piritsi limodzi kawiri patsiku (m'mawa ndi madzulo). Palibe kusiyana pakumwa mankhwala musanadye kapena musanadye. Njira yogwiritsira ntchito "Galvus" iyenera kusankhidwa palokha, poganizira nthawi yogwira ntchito komanso kulolerana.

Ikani mankhwalawa pakamwa, pakumwa piritsi ndi madzi okwanira. Mlingo wa mankhwalawa sayenera kupitirira 100 mg patsiku.

Mankhwala "Galvus" amagwiritsidwa ntchito ngati:

• monotherapy, kuphatikiza ndi zakudya komanso osati amphamvu, koma zolimbitsa thupi mokhazikika (mwachitsanzo, "Galvus" + zakudya + masewera),
• chithandizo choyambirira cha matenda a shuga osakanikirana ndi mankhwala ochepetsa shuga a Metformin, pamene kudya ndi kuchita masewera olimbitsa thupi sizimapereka zotsatira zabwino (mwachitsanzo, "Galvus" + Metformin + zakudya + masewera),
• chithandizo chovuta limodzi ndi mankhwala ochepetsa shuga kapena insulin, ngati kudya, kuchita masewera olimbitsa thupi komanso chithandizo ndi Metformin / insulin yokha sizithandiza (mwachitsanzo, "Galvus" + Metformin kapena zotumphukira za sulfonylurea, kapena thiazolidinedione, kapena insulin + zakudya + masewera),
• Kuphatikiza chithandizo: sulfonylurea zotumphukira + Metformin + "Galvus" + zakudya chakudya + maphunziro akuthupi, pamene chithandizo chofanana, koma popanda "Galvus" sichinathandize.
• mankhwalawa: Metformin + insulin + Galvus, pomwe mankhwala ofanana kale, koma popanda Galvus, sanatulutse zotsatira zomwe amayembekeza.

Anthu odwala matenda ashuga amagwiritsa ntchito mankhwalawa:

• monotherapy - 50 mg / tsiku (m'mawa) kapena 100 mg / tsiku (i. 50 mg m'mawa ndi madzulo),
• Metformin + "Galvus" - 50 mg 1 kapena 2 pa tsiku,
• Sulfonylurea zotumphukira + "Galvus" - 50 mg / tsiku (1 nthawi patsiku, m'mawa),
• thiazolidinedione / insulin (china mwa mndandanda) + "Galvus" - 50 mg 1 kapena 2 kawiri pa tsiku,
• zotumphukira za sulfonylurea + Metformin + Galvus - 100 mg / tsiku (mwachitsanzo, kawiri patsiku, 50 mg, m'mawa ndi madzulo),
• Metformin + insulin + "Galvus" - 50 mg 1 kapena 2 kawiri pa tsiku.

Mukamamwa "Galvus" ndi sulfonylurea kukonzekera, mlingo wa wotsiriza kuchepetsapopewa kukula kwa hypoglycemia!

Zoyenera, mukamamwa mankhwalawa kawiri patsiku, muyenera kumwa mapiritsi ena 12 maola atatha. Mwachitsanzo, nthawi ya 8 am iwo adatenga piritsi limodzi (50 mg) ndipo nthawi ya 8 pm iwo amatenga piritsi limodzi (50 mg). Zotsatira zake, 100 mg ya mankhwalawa amatengedwa patsiku.

Mlingo wa 50 mg amatengedwa nthawi imodzi, osagawika pawiri.

Ngati mulingo uwu sukupereka zotsatira zabwino, ngakhale kuti ndimachangu chovuta, ndiye kuti ndikofunikira kuwonjezera mankhwala ena kuwonjezera pamenepo, koma ndizosatheka kuwonjezera kuchuluka kwa Galvus kupitilira 100 mg / tsiku!

Anthu odwala matenda ashuga omwe ali ndi matenda ofatsa a ziwalo za parenchymal (i.e., impso kapena chiwindi) nthawi zambiri amagwiritsa ntchito Mlingo wa 50 mg. Anthu omwe ali ndi zilema zoopsa (ngakhale atakhala ndi mawonekedwe a matenda a impso kapena chiwindi), Galvus, monga lamulo, silomwe limasankhidwa.

Mwa okalamba (kuyambira zaka 60 kapena kupitirira), Mlingo wa mankhwalawa ndiwofanana ndi wa achinyamata. Komabe, nthawi zambiri, anthu achikulire amalamulidwa kumwa 50 mg kamodzi patsiku.

Mulimonsemo, mankhwalawa "Galvus" ayenera kugwiritsidwa ntchito mosamalitsa ndikuyang'aniridwa ndi dokotala.

Achinyamata a 2 odwala matenda ashuga, i.e. Ana ndi achinyamata azaka zosakwana ambiri sayenera kumwa mankhwalawa, chifukwa sanayesedwe pa gulu la anthu azaka zam'mbuyomu panthawi yoyesedwa.

Amayi omwe ali ndi mwana wosabadwa saloledwa kugwiritsa ntchito mankhwalawa. M'malo mwake, amatha kugwiritsa ntchito mankhwala a mahomoni achizolowezi (i.e. insulin).

Komabe, zomwe takumana nazo madotolo zimawonetsa kuti palibe zoyipa pakukula kwa pakati pa 50 mg patsiku, komabe ndibwino kukana kugwiritsa ntchito mankhwalawa ngati zingatheke. Chifukwa chake, kugwiritsa ntchito kwa "Galvus" ndi azimayi oyembekezera kungathekebe, koma pothandizidwa ndi akatswiri.

Ndikulimbikitsidwanso kuti musiye kumwa mankhwalawa panthawi yoyamwitsa, chifukwa palibe amene amadziwa ngati chinthu chogwira chimalowa mkaka kapena ayi.

Kuthekera kotheka

Monga mankhwala ena, ilinso ndi zotsutsana. Kwenikweni, ngakhale zinthu zosafunikira zikaonekera, ndizakanthawi ndipo zimatha kwakanthawi, kotero kusintha kwa mankhwalawa kupita kwina kulikonse sikunaperekedwe.

Contraindication wa mankhwalawa ndi awa:

1. Zovuta kwambiri pakugwira ntchito kwa impso, chiwindi ndi / kapena mtima.
2. Metabolic acidosis, matenda ashuga ketoacidosis, lactic acidosis, chikomokere shuga.
3. Mtundu woyamba wa shuga.
4. Mimba komanso yoyamwitsa.
5. Zaka za ana.
6. Thupi lonse la mankhwala kapena chimodzi.
7. Galactose tsankho.
8. Lactase akusowa.
9. Kuwonongeka kwa kugaya chakudya komanso kuchuluka kwa shuga-galactose.
10. Kuwonjezeka kwa hepatic enzymes (ALT ndi AST) m'magazi.

Mosamala, mankhwalawa "Galvus" ayenera kugwiritsidwa ntchito kwa anthu omwe atha kufalikira kwa kapamba.

Zotsatira zoyipa

Zotsatira zoyipa zimachitika kawirikawiri ndi mankhwala osokoneza bongo:

• chizungulire, kupweteka mutu,
• kugwedezeka
• kuzizira
• kusanza, kusanza,
• gastroesophageal Reflux,
• kutsegula m'mimba, kudzimbidwa, kugonja,
• achina,
• hyperhidrosis
• kuchepa kwa ntchito ndi kutopa,
• zotumphukira edema,
• kunenepa.

Mankhwala "Galvus" akuwonetsedwa ngati matenda amitundu iwiri. Chidacho chili ndi mawonekedwe pakugwiritsa ntchito komanso mlingo. Mankhwala amathandiza thupi, amatulutsa shuga mumagazi. Chipangizochi chili ndi zoyipa ndi zoyipa, chifukwa anthu ena ayenera kuzigwiritsa ntchito mosamala.

Kugwiritsa

Galvus ndi mankhwala omwe amapangitsa kuti shuga azikhala mthupi. Amangotengedwa pakamwa pokha. Mankhwalawa amalimbikitsa kukhudzika kwa minofu ku glucose, omwe amathandiza insulin kutuluka.

Vildagliptin ndi mankhwala omwe amapezeka mu mankhwala. Zimathandizira kukhala ndi maselo a pancreatic beta.

Ngati munthu alibe matenda a shuga, ndiye kuti mankhwalawo samathandizira kuti amasulidwe komanso asasinthe kuchuluka kwa shuga m'magazi oyenda.

Galvus imatha kuyambitsa ma lipids otsika kwambiri m'thupi. Izi sizimayendetsedwa ndi kusintha kwa magwiridwe antchito a minyewa.

Galvus imatha kuchepetsa matumbo. Izi sizikugwirizana ndi ntchito ya vildagliptin.

Galvus Met ndi mtundu wina wamankhwala. Kuphatikiza pa vildagliptin, imakhala ndi metformin yogwira ntchito.

Zizindikiro zazikulu za kutenga mankhwala a mtundu 2 shuga

• Kwa monotherapy, kuphatikiza ndi zakudya komanso masewera olimbitsa thupi oyenera.
• Odwala omwe m'mbuyomu adagwiritsa ntchito mankhwala omwe ali ndi metformin kwathunthu.
• Pa monotherapy, kuphatikiza ndi metformin. Imagwiritsidwa ntchito ngati zolimbitsa thupi ndi zakudya sizinabweretse zotsatira zomwe mukufuna.
• Kuphatikiza pa insulin.
• Kugwiritsa ntchito mosakaniza mankhwala. Nthawi zina, amaloledwa kutenga insulin, metformin ndi vildagliptin palimodzi.

Vildagliptin, ngati itengedwa pamimba yopanda kanthu, imatengedwa mwachangu ndi thupi. Mukamadya, kuchuluka kwa mayamwidwe kumachepa. Vildagliptin, pakukhala m'thupi, imasandulika ma metabolites, pambuyo pake imasiya madzi amkodzo.

Malangizo a Galvus meth ogwiritsira ntchito akuwonetsa kuti kugonana ndi thupi la munthu sizimakhudza ma pharmacokinetic katundu wa vildagliptin.Kafukufuku wokhoza kuwona zotsatira za vildagliptin kwa ana osaposa zaka 18 sanachitike.

Metformin, yomwe ili ndi Galvus Met, imachepetsa kuyamwa kwa mankhwalawa chifukwa chakudya. Vutoli siligwirizana ndi madzi am'magazi. Metformin imatha kulowa m'magazi ofiira, zotsatira zake zimachulukana ndikugwiritsa ntchito nthawi yayitali. Thupi limangotsala ndi impso, osasintha maonekedwe ake. Bile ndi metabolites sizipangidwe.

Palibe maphunziro omwe adachitidwa omwe akuwonetsa zomwe Galvus zimapangitsa thupi la mayi wapakati. Sindikulimbikitsidwa kumwa mankhwalawa nthawi imeneyi (m'malo mwa mankhwala a insulin).

Malangizo ogwiritsira ntchito

Galvus imatengedwa ndi pakamwa pokha. Nthawi yopeza chakudya sikofunikira. Mapiritsiwo samatafuna, osambitsidwa ndi madzi okwanira.

Mukamamwa mankhwala osokoneza bongo, chisamaliro chachikulu chiyenera kulipira pakulimbana ndi mankhwala:

• Vildagliptin wokhala ndi metformin. Mukamamwa zinthu zonse ziwiri mwanjira zovomerezeka, palibe zotsatira zina zapezeka. Vildagliptin mwina samayanjana ndi mankhwala ena. Sikugwiritsidwa ntchito ndi zoletsa. Mavuto a vildagliptin m'thupi limodzi ndimankhwala ena omwe amafunsira mtundu wachiwiri wa shuga sanakhazikitsidwe. Chenjezo liyenera kuchitidwa.
• Metformin. Ngati atengedwa ndi Nifedipine, ndiye kuti kuchuluka kwa mayamwidwe a metformin kumawonjezeka. Metformin ilibe gawo lililonse pa zinthu za Nifedipine. Glibenclamide, kuphatikiza ndi thunthu, iyenera kumwedwa mosamala: zotsatirazi zingasiyane.

Galvus iyenera kumwedwa mosamala ndi mankhwala omwe amakhudza ntchito ya impso.

Kugwiritsa ntchito Galvus ndi chlorpromazine sikulimbikitsidwa. Chifukwa cha izi, kuchuluka kwa insulin katulutsidwe kumachepetsedwa. Kusintha kwa magazi kumafunika.

Sizoletsedwa kumwa mankhwala okhala ndi Mowa ndi Galvus. Izi zimawonjezera mwayi wa lactic acidosis. M'pofunikanso kupewa kumwa mowa uliwonse.

Contraindication

Galvus ali ndi zotsutsana zingapo:

• Kuwonongeka kwa impso, kulephera kwa aimpso.
• Matenda ndi zinthu zomwe zingayambitse matenda aimpso. Mwa izi, kusowa kwamadzi, kutentha thupi, matenda, komanso kuchepa kwa okisijeni mthupi kumatha.
• Matenda a mtima, myocardial infarction.
• Zovuta zamkati zopuma.
• Kulephera kwa chiwindi.
• Pachimake kapena kusuntha kosasintha kwa asidi-maziko olimba. Panthawi imeneyi, mankhwala a insulin amagwiritsidwa ntchito.
• Mankhwalawa sagwiritsidwa ntchito masiku awiri asanachitike opaleshoni kapena mayeso. Komanso, musatenge masiku opitilira 2 patatha masiku.
• Mtundu woyamba wa shuga.
• Kumwa mowa pafupipafupi komanso kudalira. Hangover Syndrome.
• Kudya chakudya chochepa. Mulingo wocheperako wothira mankhwalawa ndi zopatsa mphamvu za 1000 tsiku lililonse.
• Hypersensitivity pazinthu zilizonse zomwe zimapezeka mu mankhwala. Itha m'malo ndi insulin, koma pokhapokha mukaonana ndi katswiri.

Palibe deta pakumwa mankhwalawa panthawi yoyembekezera komanso mkaka wa m`mawere. Gwiritsani ntchito mankhwalawa ndiwotsutsana. Chiwopsezo chokhala ndi vuto la kubereka mwa mwana wosabadwa chikuchulukirachulukira. Kuchotsa mankhwalawa ndi mankhwala a insulin kumalimbikitsidwa.

Mankhwalawa amaleredwa mwa ana akula. Kafukufuku wokhudza gulu ili la anthu sanachitepo kanthu.

Mankhwala ayenera kugwiritsidwa ntchito mosamala kwambiri kwa anthu azaka zopitilira 60. Kuyang'aniridwa mosamala kuchipatala nthawi yonseyi kumafunika.

Mlingo wa Galvus umayikidwa payekhapayekha kwa wodwala aliyense. Zimatengera kulolera kwa thupi ndi mankhwala ena omwe amagwiritsidwa ntchito ngati monotherapy.

Mlingo wa mankhwala omwe amagwiritsidwa ntchito pa monotherapy ndi insulin amachokera ku 0,55 mpaka 0,1 ga yogwira tsiku lililonse. Ngati wodwala akudwala matenda oopsa a shuga, tikulimbikitsidwa kuti ayambe kumwa mankhwalawa ndi 0,5 g.

Ngati pamodzi ndi Galvus magawo awiri oyandikana nawo agwiritsidwa ntchito, ndiye kuti mankhwalawa amayamba ndi 0,1 g tsiku lililonse. Mlingo wa 0,05 g uyenera kumwa nthawi. Ngati mlingo ndi 0,1 ga, ndiye kuti uyenera kutambasulidwa mu 2 Mlingo: m'mawa ndi madzulo.

Ndi monotherapy, komanso kukonzekera kwa sulfonylurea, mlingo wofunikira ndi 0,05 g tsiku lililonse. Sitikulimbikitsidwa kutenga zochulukirapo: kutengera maphunziro apachipatala, zidapezeka kuti Mlingo wa 0,05 g ndi 0,1 g kwenikweni sizimasiyana pogwira ntchito. Ngati chithandizo chamankhwala chomwe mukufuna sichinachitike, ndiye kuti mulingo wa 0,1 g ndi mankhwala ena omwe shuga yotsika magazi amaloledwa.

Ngati wodwala ali ndi vuto laling'ono ndikugwira ntchito kwa impso, ndiye kuti kusintha kwa mlingo sikofunikira. Mankhwalawa akuyenera kuchepetsedwa kukhala 0,05 g ngati muli ndi vuto lalikulu la impso.

Tiyeni tipitilize kuganizira za mankhwalawa a Galvus Met.

Mlingo amasankhidwa payekha kwa wodwala aliyense. Saloledwa kupitilira muyeso wa tsiku ndi tsiku la yogwira - 0,5 g.

Ngati chithandizo cha mankhwala ndi Galvus wamba sichinabweretse zotsatira zomwe mukufuna, ndiye kuti mlingo uyenera kuyamba ndi 0,05 g / 0,5 g awa ndi vildagliptin ndi metformin, motero. Mlingo utha kuwonjezereka potengera kuwunika kwa mankhwalawa. Ngati metformin sikunapereke zotsatira zabwino mankhwalawo, ndiye kuti mutenge Galvus Met m'malingaliro otsatirawa: 0.05 g / 0,5 g, 0,55 g / 0,85 g kapena 0,05 g / 1 g. nthawi.

Mlingo woyambirira wa odwala omwe amathandizidwa kale ndi metformin ndi vildagliptin zimatengera umunthu wa mankhwalawo. Izi zitha kukhala zotsatirazi Mlingo: iyenera kuyamba ndi 0,05 g / 0,5 g, kutengedwa nthawi 1. Pang'onopang'ono, mlingo uyenera kuwonjezeka mpaka 0,05 g / 1 g.

Mwa anthu achikulire, kuchepa kwa ntchito ya impso nthawi zambiri kumawonedwa. Zikatero, muyenera kumwa mulingo wochepa wa mankhwalawa, omwe amatha kuwongolera shuga. Ndikofunikira kumayeserera nthawi zonse komwe kumawululira za impso.

• Mapiritsi a Galvus a 0,05 g yogwiritsira ntchito pophika angagulidwe kwa ma ruble 814.
• Galvus Met, mtengo wake ndi ma ruble 1,500 pamapiritsi 30 okhala ndi mitundu yosiyanasiyana ya metformin ndi vildagliptin. Chifukwa chake, mwachitsanzo, galvus meth 50 mg / 1000 mg ingagule ma ruble 1506.

Mankhwalawa onse ndi mankhwala.

Ganizirani mankhwala omwe amalowa m'malo mwa Galvus:

• Arfezetin. Ntchito ngati mankhwala a odwala matenda ashuga. Kwa chithandizo chokwanira sikokwanira. Pafupifupi palibe mavuto, angagwiritsidwe ntchito monotherapy. Ubwino wake ndi wotsika mtengo - ma ruble 69. Kugulitsa popanda mankhwala.
• Victoza. Mankhwala okwera mtengo komanso ogwira mtima. Muli liraglutide mu kapangidwe kake. Amapezeka mu ma syringes. Mtengo - 9500 rub.
• Glibenclamide. Chimalimbikitsa kumasulidwa kwa insulin. Muli yogwira mankhwala glibenclamide mu kapangidwe kake. Mutha kugula mankhwala a ruble 101.
• Glibomet. Imathandizira kukula kwa shuga ndi magazi. Mapiritsi 20 a mankhwalawa angagulidwe kwa ma ruble 345.
• Glidiab. Zomwe zimagwiritsidwa ntchito ndi gliclazide. Zimawonjezera kukhudzika kwa minofu ku insulin. Zosintha pamtengo wotsika mtengo komanso kuchita bwino. Mankhwala angagulidwe kwa ma ruble a 128. - Mapiritsi 60.
• Glformin. Zomwe zimagwiritsidwa ntchito ndi metformin. Ili ndi zovuta zochepa. Mtengo - ma ruble 126 a mapiritsi 60.
• Glucophage. Muli ndi metformin hydrochloride. Simalimbikitsa kupanga insulin. Itha kugulika ma ruble 127.
• Galvus. Amasintha kayendedwe ka glycemic. Ndizovuta kupeza m'mafakitala aku Russia, makamaka ku St.
• Glucophage Kutalika. Zofanana ndi mnzake wakale. Kusiyanitsa ndiko kumasulidwa kwapang'onopang'ono kwa zinthu. Mtengo - 279 rub.
• Diabetes. Kuchepetsa kuchuluka kwa shuga muzozungulira. Ntchito kuperewera kwa matenda a thanzi. Mtengo wamapiritsi 30 ndi ma ruble 296.
• Maninil. Muli glibenclamide. Itha kugwiritsidwa ntchito ngati gawo la monotherapy. Mtengo wake ndi ma ruble 118. mapiritsi 120.
• Metformin. Imathandizira njira yamapangidwe a glycogen. Imathandizira minofu kugwedezeka. Kugulitsa ndi mankhwala. Mtengo - 103 ma ruble. mapiritsi 60.
• Siofor. Ili ndi metformin. Imachepetsa kupanga shuga, imawonjezera katemera wa insulin. Itha kugwiritsidwa ntchito ngati monotherapy. Mtengo wapakati ndi ma ruble 244.
• Fomu. Imachepetsa gluconeogeneis ndikuwonjezera mphamvu ya minofu ku insulin. Sizitenga nawo gawo popanga insulin. Mutha kugula ma ruble 85.
• Januvius. Muli yogwira mankhwala sitagliptin. Itha kugwiritsidwa ntchito ngati gawo la monotherapy. Kugulitsidwa ma ruble 1594.

Awa anali otchuka kwambiri a Galvus ndi Galvus Met. Kusintha kwayekha kuchoka pa mankhwala kupita kwina sikuloledwa. Kukambirana ndi katswiri ndikofunikira.

Bongo

Mankhwala osokoneza bongo a vildagliptin amapezeka pamene kuchuluka kwawonjezeka mpaka 0,4 g.

• Ululu m'matumbo.
• Mikhalidwe.
• Kutupa.

Chithandizo chimakhala kukana kwathunthu kwa mankhwala kwakanthawi. Dialysis sikugwiritsidwa ntchito. Komanso, chithandizo chingakhale chisonyezo.

Mankhwala osokoneza bongo a metformin amapezeka pogwiritsa ntchito zoposa 50 g ya chinthucho. Pankhaniyi, hypoglycemia ndi lactic acidosis imatha kuonedwa. Zizindikiro zazikulu:

• Kutsegula m'mimba
• Kutentha kochepa.
• Ululu pamimba.

Zikatero, ndikofunikira kusiya mankhwalawo. Zochizira, hemodialysis imagwiritsidwa ntchito.

Ganizirani ndemanga zomwe anthu amasiya za Galvus kapena Galvus Met:

Ndemanga za Galvus zikuwonetsa kuti uwu ndi mwayi wabwino wolamulira shuga. Anthu omwe amagwiritsa ntchito mankhwalawa amadziwa zabwino zake.

Zotsatira zoyipa

Mwambiri, galvus ndi mankhwala otetezeka kwambiri. Kafukufuku akutsimikizira kuti chithandizo cha matenda amtundu wa 2 omwe ali ndi mankhwalawa samakulitsa chiwopsezo cha matenda amtima, mavuto a chiwindi, kapena vuto la chitetezo chamthupi. Kutenga vildagliptin (chophatikiza yogwira m'mapiritsi a galvus) sikukula thupi.

Poyerekeza ndi mafuta am'magazi ochepetsa shuga, komanso ndi placebo, galvus siziwonjezera chiopsezo cha kapamba. Zotsatira zake zoyipa zimakhala zofatsa komanso zosakhalitsa. Zosawonetseka kwambiri:

• kuwonongeka kwa chiwindi (kuphatikizapo chiwindi),
• angioedema.

Zomwe zimayambitsa zotsatirazi ndizoyambira 1/1000 mpaka 1/10 000 odwala.