Protaphane® HM (Protaphane® HM)

Protafan ® HM Penfill ®

Zotsatira za pharmacological

Amalumikizana ndi membrane membrane wa plasma ndikulowa mu cell, momwe imayambitsa phosphorylation ya mapuloteni am'magazi, imalimbikitsa glycogen synthetase, pyruvate dehydrogenase, hexokinase, inhibits minofu ya lipip ndi lipoprotein lipase. Kuphatikiza ndi cholandilira china chake, chimathandizira kulowa kwa glucose m'maselo, kumathandizira kukoka kwake ndi minofu ndikulimbikitsa kutembenuka kukhala glycogen. Kuchulukitsa minofu ya glycogen, kumapangitsa kaphatikizidwe ka peptide.

Clinical Pharmacology

Zotsatira zimayambika maola 1.5 pambuyo poyang'anira sc, zimafika patadutsa maola 4-12 ndipo zimatha maola 24. Protafan NM Pulogalamu yodwala matenda a shuga omwe amadalira insulin amagwiritsidwa ntchito ngati insulin insulin limodzi ndi insulin yotsalira, kwa osagwirizana ndi insulini - monga monotherapy , komanso kuphatikiza ma insulini othamangira.

Kuchita

Zotsatira za hypoglycemic zimapangidwira ndi acetylsalicylic acid, mowa, alpha ndi ma beta blockers, amphetamine, anabolic steroids, clofibrate, cyclophosphamide, phenfluramine, fluoxetine, ifosfamide, MAO zoletsa, methyldopa, tetracycline, trifamazidigigidi, trifamizidigigidi, trifamizidigigidi, trifamizigidigigidi, trifamizigidigigidi, trifamigidigigidi, trifamigidigigidi, trifamizigigidi, trifamigidigigidi, trifamizigidigigidi, trifamizigigidi, trifamizigigidi, trifamizigidigigidi, trifamizigigidi. thiazides), glucocorticoids, heparin, kulera kwa mahomoni, isoniazid, lithiamu carbonate, nicotinic acid, phenothiazines, audiathomimetics, tricyclic antidepressants.

Mlingo ndi makonzedwe

Protafan ® HM Penfill ®

P / c. Mankhwala anaupanga subcutaneous makonzedwe. Kuyimitsidwa kwa insulin sikungalowe / kulowa.

Mlingo wa mankhwalawa amasankhidwa payekha, poganizira zosowa za wodwala. Nthawi zambiri, zofunika za insulin zimakhala pakati pa 0.3 ndi 1 IU / kg / tsiku. Kufunika kwa insulini tsiku lililonse kumatha kukhala kwabwino kwambiri kwa odwala omwe ali ndi insulin (mwachitsanzo, nthawi yakutha msinkhu, komanso odwala omwe ali ndi kunenepa kwambiri), komanso otsika mwa odwala omwe ali ndi zotsalira za insulin.

Protafan ® NM itha kugwiritsidwa ntchito pa monotherapy komanso kuphatikiza mwachangu kapena mwachidule.

Protafan ® NM nthawi zambiri imayendetsedwa mwachangu mu ntchafu. Ngati izi ndizotheka, ndiye kuti jakisoni amathanso kuchitika khoma lakumbuyo kwamkati, m'chigawo cha gluteal kapena minofu ya m'mapewa. Ndi kukhazikitsidwa kwa mankhwalawa mu ntchafu, pali kuyamwa pang'onopang'ono kuposa komwe kumayambitsa madera ena. Ngati jakisoniyo wapangidwira pakhungu lalitali, ngozi ya mankhwalawo mwangozi imachepetsedwa.

Singano imayenera kukhalabe pansi pakhungu kwa masekondi 6 osachepera, omwe amatsimikizira mlingo wokwanira. Ndikofunikira nthawi zonse kusintha malo a jekeseni mkati mwa anatomical dera kuti muchepetse kukula kwa lipodystrophy.

Protafan ® NM Penfill ® idapangidwa kuti igwiritsidwe ntchito ndi NOvo Nordisk insulin jakisoni ndi singano za NovoFine ® kapena NovoTvist ®. Malangizo atsatanetsatane ogwiritsira ntchito ndi kuyang'anira mankhwalawa amayenera kuonedwa.

Matenda okhala ndi vuto limodzi, makamaka opatsirana komanso kutentha thupi, nthawi zambiri amalimbikitsa kufunika kwa insulin. Kusintha kwa magazi kungafunikenso ngati wodwala ali ndi matenda a impso, chiwindi, mkhutu wa adrenal ntchito, pituitary kapena chithokomiro cha chithokomiro. Kufunika kosinthidwa kwa mlingo kumatha kuonekanso posintha zolimbitsa thupi kapena zakudya zomwe wodwala amadya. Kusintha kwa Mlingo kungafunike posamutsa wodwala kuchokera ku mtundu wina wa insulin kupita ku ina

Bongo

Zizindikiro Kukula kwa hypoglycemia (thukuta lozizira, palpitations, kugwedezeka, kugona, kukwiya, kusokonekera, pallor, kupweteka mutu, kugona, kusowa poyenda, kuyankhula ndi kuwonongeka kwamaso, kukhumudwa). Hypoglycemia imatha kubweretsa kuwonongeka kwakanthawi kapena kugwira ntchito kwa ubongo, chikomokere, ndi kufa.

Chithandizo: shuga kapena shuga mkati mwake (ngati wodwalayo akudziwa), s / c, i / m kapena iv - glucagon kapena iv - glucose.

Kutulutsa Fomu

Kuyimitsidwa kwa kayendetsedwe ka subcutaneous, 100 IU / ml (mbale). Mumabotolo amgalasi ya hydrolytic kalasi yoyamba, yokhala ndi zotsekemera kuchokera ku rongosutyl / polyisoprene rabara ndi zipewa za pulasitiki, 10 ml iliyonse, muthumba la makatoni 1 fl.

Kuyimitsidwa kwa kayendetsedwe ka subcutaneous, 100 IU / ml (makatoni). Mu 3 ml ma Penfill ® galasi makatoni, makatoni 5 m'matumba, 1 chithuza chonyamula makatoni.