Metformin (500 mg) Metformin > Chithandizo ndi kupewa

Mapiritsi, 500 mg, 850 mg ndi 1000 mg

Piritsi limodzi la 500 mg lili:

ntchito yogwira: metformin hydrochloride - 500 mg.

muobwera: microcrystalline cellulose, croscarmellose sodium, madzi oyeretsedwa, povidone (polyvinylpyrrolidone), magnesium stearate.

Piritsi limodzi la 850 mg lili:

ntchito yogwira: metformin hydrochloride - 850 mg.

muothandizira zinthu: cellcrystalline cellulose, croscarmellose sodium, madzi oyeretsedwa, povidone (polyvinylpyrrolidone), magnesium stearate.

Piritsi limodzi la 1000 mg lili:

yogwira chinthu: metformin hydrochloride - 1000 mg.

auxmachiritso zinthu: cellcrystalline cellulose, croscarmellose sodium, madzi oyeretsedwa, povidone (polyvinylpyrrolidone), magnesium stearate.

Mapiritsi 500 mg - mapiritsi ozungulira ozungulira amiyala yoyera kapena pafupifupi oyera okhala ndi chiopsezo mbali imodzi ndi chamfer kumbali zonse ziwiri.

Mapiritsi 850 mg, 1000 mg - mapiritsi a oic biconvex amtundu woyera kapena pafupifupi woyera wokhala ndi chiopsezo mbali imodzi.

Mankhwala

Pharmacokinetics

Pambuyo pakukonzekera pakamwa, metformin imatengedwa kuchokera kumimba kwathunthu. Mtheradi bioavailability ndi 50-60%. The ndende yambiri (Cmax) (pafupifupi 2 μg / ml kapena 15 μmol) mu plasma imatheka pambuyo maola 2,5.

Ndi kuyamwa kwa munthawi yomweyo, kuyamwa kwa metformin kumachepetsedwa ndikuchedwa.

Metformin imagawidwa mwachangu mu minofu, sikuti imagwira mapuloteni a plasma. Amapangidwira pamlingo wofooka kwambiri ndikuwonetsa impso. Kuvomerezeka kwa metformin m'maphunziro abwino ndi 400 ml / mphindi (kuchulukitsa kanayi kuposa kutulutsa chilolezo cha creatinine), zomwe zikuwonetsa kukhalapo kwa secalic secretion. Hafu ya moyo ndi pafupifupi maola 6.5. Ndi kulephera kwa aimpso, zimachulukana, pamakhala chiopsezo cha kupezeka kwa mankhwalawa.

Metformin imachepetsa hyperglycemia popanda kutsogola kukula kwa hypoglycemia. Mosiyana ndi zotumphukira za sulfonylurea, sizimalimbikitsa kutulutsa insulin ndipo sizikhala ndi vuto loti munthu azikhala wathanzi. Zimawonjezera chidwi cha zotumphukira zolandilira ku insulin ndikugwiritsa ntchito shuga ndi maselo. Amalepheretsa gluconeogenesis m'chiwindi. Imachedwetsa mayamwidwe am'mimba m'matumbo. Metformin imathandizira kapangidwe ka glycogen pochita glycogen synthase. Kuchulukitsa kuchuluka kwa mayendedwe amtundu uliwonse wa ma membrane glucose.

Kuphatikiza apo, imakhala ndi phindu pa metabolidi ya lipid: imachepetsa zomwe zimakhala ndi cholesterol yonse, lipoproteins yotsika komanso triglycerides.

Ngakhale mutamwa metformin, thupi la wodwalayo limakhalabe lolimba kapena limatsika pang'ono.

Zizindikiro zogwiritsidwa ntchito

Type 2 shuga mellitus, makamaka kwa odwala omwe ali ndi kunenepa kwambiri, komanso kulephera kwamankhwala othandizira kudya komanso zochitika zolimbitsa thupi:

• Akuluakulu, monga monotherapy kapena kuphatikiza ena othandizira pakamwa, kapena ndi insulin,

• mwa ana kuyambira zaka 10 monga monotherapy kapena kuphatikiza insulin.

Mlingo ndi makonzedwe

Mapiritsi amayenera kumwedwa pakamwa, kumeza lonse, osafuna kutafuna, pakudya kapena mukangomaliza kudya, kumwa madzi ambiri.

Akuluakulu: monotherapy ndi kuphatikiza mankhwalawa kuphatikiza ena othandizira pakamwa:

• Mlingo woyambira wamba ndi 500 mg kapena 850 mg katatu patsiku mutatha kudya kapena pakudya. Kuwonjezereka kwapang'onopang'ono kwa mlingo kumatha kutengera kuchuluka kwa shuga m'magazi.

• Mankhwala okonza mankhwalawa nthawi zambiri amakhala 1500-2000 mg / tsiku. Kuti muchepetse mavuto kuchokera m'matumbo am'mimba, mlingo wa tsiku ndi tsiku uyenera kugawidwa mu Mlingo wa 2-3. Mlingo wapamwamba ndi 3000 mg / tsiku, logawidwa pazidutswa zitatu.

• Kuchepetsa kwa pang'onopang'ono kumathandizanso kulolerana kwam'mimba.

• Odwala omwe akutenga metformin mu Mlingo wa 2000-3000 mg / tsiku amatha kusamutsira ku 1000 mg. Mlingo woyenera kwambiri ndi 3000 mg / tsiku, womwe umagawidwa pazigawo zitatu.

Pankhani yakukonzekera kusinthaku kuti mutenge wina wothandizila wa hypoglycemic: muyenera kusiya kumwa mankhwalawa ndikuyamba kumwa Metformin muyezo womwe tafotokozazi.

Kuphatikiza ndi insulin:

Kukwaniritsa bwino shuga wamagazi, metformin ndi insulin zitha kugwiritsidwa ntchito ngati mankhwala ophatikiza. Mlingo woyamba wa Metformin 500 mg kapena 850 mg piritsi limodzi katatu patsiku, Metformin 1000 mg ndi piritsi limodzi nthawi imodzi patsiku, pamene insulini imasankhidwa potengera kuchuluka kwa shuga m'magazi.

Ana ndi achinyamata: mwa ana azaka 10, mankhwala Metformin angagwiritsidwe ntchito onse mu monotherapy komanso kuphatikiza insulin. Mulingo woyambira woyamba ndi 500 mg kapena 850 mg 1 nthawi patsiku mutatha kudya kapena. Pambuyo masiku 10-15, mlingo uyenera kusinthidwa potengera kuchuluka kwa magazi. Mulingo wambiri watsiku ndi tsiku ndi 2000 mg, wogawidwa pamitundu iwiri.

Odwala okalamba: chifukwa cha kuchepa kwa aimpso, mlingo wa metformin uyenera kusankhidwa poyang'anitsitsa mawonetseredwe aimpso (kudziwa kuchuluka kwa creatinine mu seramu osachepera 2-4 pachaka).

Kutalika kwa mankhwala kumatsimikiziridwa ndi adokotala. Kuchotsera kwa mankhwalawa popanda upangiri wa dokotala simukulimbikitsidwa.

Kugwiritsa ntchito mankhwala

Mapiritsi a Metformin amatengedwa pakamwa.

Mukamamwa mankhwalawa, ndikofunika kuti mapiritsiwo amezedwe lonse osafuna.

Mankhwalawa ayenera kugwiritsidwa ntchito pakudya kapena pambuyo pake. Tengani piritsi ndi madzi okwanira.

Chizindikiro chachikulu chogwiritsa ntchito mankhwalawa ndi kupezeka kwa mtundu wachiwiri wa shuga wodwala.

Malangizo ogwiritsira ntchito akuwonetsa kuti mankhwalawa amatha kugwiritsidwa ntchito popanga monotherapy kapena ngati gawo la zovuta mankhwala ndi mankhwala ena okhala ndi katundu wa hypoglycemic kapena kuphatikiza ndi inulin.

Malangizo ogwiritsira ntchito amalola kugwiritsa ntchito mankhwalawa ali mwana, kuyambira zaka 10. Kugwiritsa ntchito mankhwalawa kumaloledwa kwa ana onse monga monotherapy, komanso kuphatikiza jakisoni wa insulin.

Mlingo woyambirira mukamamwa mankhwala ndi 500 mg. Mankhwala tikulimbikitsidwa kuti kumwedwa katatu patsiku. Ngati ndi kotheka, ndikuvomerezedwa kwina, mlingo wa mankhwalawa ukhoza kuchuluka. Kuwonjezeka kwa mlingo womwe umatengedwa kumadalira kuchuluka kwa shuga m'thupi.

Mukamagwiritsa ntchito Metformin pantchito yokonza mankhwalawa, mlingo womwe umatengedwa umasiyana kuchokera ku 1,500 mpaka 2,000 mg patsiku. Mlingo wa tsiku ndi tsiku uyenera kugawidwa pawiri, kugwiritsa ntchito mankhwalawa kupewa kupewa mavuto obwera chifukwa cha kugaya chakudya. Mlingo wovomerezeka wokwanira malinga ndi malangizo ogwiritsira ntchito ndi 3000 mg patsiku.

Mukamamwa mankhwalawa, mulingo woyenera umafunika kuwonjezeredwa pang'onopang'ono mpaka mulingo woyenera utafikiridwa, njira iyi ithetsera kulolerana kwa mankhwalawo kupita m'mimba.

Ngati wodwala ayamba kumwa Metformin pambuyo pa mankhwala ena a hypoglycemic, ndiye kuti musanamwe Metformin mankhwala ena ayenera kusiyiratu.

Mukamagwiritsa ntchito mankhwalawa muubwana, mankhwala ayenera kuyambitsidwa ndi Mlingo wa 500 mg kamodzi patsiku. Pambuyo masiku 10-15, kuyezetsa magazi kwa glucose kumachitika ndipo ngati kuli kotheka, Mlingo wa mankhwala omwe amwedwa umasinthidwa. Mlingo wapamwamba tsiku lililonse wa odwala muubwana ndi 2000 mg. Mlingo uwu uyenera kugawidwa pakulipika kwa 2-3 patsiku.

Ngati mankhwalawa akugwiritsidwa ntchito ndi anthu okalamba, kusintha kwa mankhwalawa kuyenera kuchitika moyang'aniridwa ndi adokotala. Kufunika kumeneku kumachitika chifukwa chakuti mwa okalamba, kukula kwa matenda osiyanasiyana a impso m'thupi ndikotheka.

Kutalika kwa mankhwalawa kumatsimikiziridwa ndi dokotala.