Actovegin® (Actovegin®)

mapiritsi okutira.

Piritsi 1 yokhala ndi:
Kernel: ntchito: zigawo za magazi: hemoderivative ya magazi a ng'ombe - 200.0 mg mu mawonekedwe a Actovegin ® granate * - 345.0 mg, zokopa: magnesium stearate - 2.0 mg, talc - 3.0 mg,
Shell: acacia chingamu - 6.8 mg, glycol sera - 0,0 mg, hypthellose phthalate - 29.45 mg, diethyl phthalate - 11.8 mg, utoto wa quinoline wachikasu aluminium varnish - 2.0 mg, macrogol-6000 - 2 95 mg, povidone-K 30 - 1.54 mg, sucrose -52.3 mg, talc - 42.2 mg, titanium dioxide - 0,86 mg.
* Actovegin ® granrate imakhala ndi: yogwira zinthu: zigawo za magazi: zikuluzikulu za hemoderivative ya magazi a ng'ombe - 200.0 mg, otuluka: povidone-K 90 - 10,0 mg, cellcosestalline cellcose - 135.0 mg.

mapiritsi okhala ndi biconvex, wokutidwa ndi chipolopolo cha utoto wachikasu, chonyezimira.

Zotsatira za pharmacological

Mankhwala
Actovegin ® ndi antihypoxant yemwe ali ndi mitundu itatu yazotsatira: metabolic, neuroprotective ndi microcirculatory. Actovegin ® imakulitsa mayamwidwe ndikugwiritsira ntchito oksijeni, omwe ali gawo la inositol phospho-oligosaccharides, zimakhudza mayendedwe ndi kugwiritsa ntchito shuga, zomwe zimapangitsa kuti pakhale kusintha kwamphamvu kwamaselo a maselo komanso kuchepa kwa mapangidwe a lactate pansi pamikhalidwe ya ischemic.

Njira zingapo za kukhazikitsa njira ya neuroprotective ya zochita za mankhwala zimaganiziridwa.

Actovegin ® imalepheretsa kukula kwa apoptosis yoyambitsidwa ndi amyloid beta peptide (AP25-35).

Actovegin modulates zochitika za nyukiliya B kappa B (NF-kB), yomwe imagwira ntchito yofunika kwambiri pakuwongolera apoptosis ndi kutupa mkati ndi mkati mwa dongosolo lamanjenje.

Njira yina yochitira zinthu imagwirizanitsidwa ndi puloteni ya enzyme poly (ADP-ribose) -polymerase (PARP). PARP ili ndi gawo lofunikira pofufuza ndikusintha kuwonongeka kwa DNA yokhazikika kamodzi, komabe, kugwira ntchito mopitirira muyeso kwa minyewa kungayambitse kufa kwa maselo pazinthu monga matenda a cerebrovascular and diabetesic polyneuropathy. Actovegin ® imalepheretsa zochitika za PARP, zomwe zimapangitsa kuti ntchito yayikulu komanso yophatikizira yamitsempha ikhale.

Zotsatira zabwino za Actovegin ® zomwe zimakhudza kuchepa kwa magazi ndi endothelium ndizowonjezereka kwa magazi othamanga a magazi, kuchepa kwa gawo la pericapillary, kuchepa kwa mamvekedwe a mawu a precapillary arterioles ndi capillary sphincters, kuchepa kwa gawo la magazi am'magazi oyenda ndi magazi ambiri. nitric oxide, yokhudza microvasculature.

Popita maphunziro osiyanasiyana, zidapezeka kuti zotsatira za mankhwalawa Actovegin ® zimachitika pasanathe mphindi 30 kuchokera pakukhazikitsidwa kwake. Kutheka kwakukulu kumawonedwa patatha maola atatu pambuyo pa makolo ndi 2-6 mawola atagwira pakamwa.

Pharmacokinetics
Pogwiritsa ntchito njira za pharmacokinetic, ndizosatheka kuwerenga magawo a pharmacokinetic a Actovegin ®, popeza amangokhala ndi zofunikira zathupi zomwe nthawi zambiri zimapezeka m'thupi.

Monga mbali ya zovuta mankhwala:

• Zizindikiro zochizira kuwonongeka kwazidziwitso, kuphatikizapo kuwonongeka pambuyo pa stroko yokhudzana ndi matenda amisala komanso kuchepa kwa chidwi.
• Zizindikiro zochizira zotumphukira zamagazi ndizotsatira zake.
• Chithandizo cha matenda ashuga polyneuropathy (DPN).

Zithunzi za 3D

Mlingo ndi makonzedwe

I / O, I / O (kuphatikizapo mawonekedwe a kulowetsedwa), mu / m.

Pokhudzana ndi kuthekera kwa kukhazikika kwa anaphylactic, tikulimbikitsidwa kuyesa kupezeka kwa hypersensitivity kwa mankhwala asanayambe kulowetsedwa.

Matenda amisempha ndi mtima. 5-25 ml (200-1000 mg wa mankhwala) patsiku i / v tsiku lililonse kwa masabata awiri, ndikutsatira kusintha kwa piritsi.

Ischemic stroke. 20-50 ml (800-2000 mg wa mankhwalawa) mu 200-300 ml ya 0,9% ya sodium kolorayidi kapena 5% iv dextrose solution yotsitsa sabata 1, ndiye 1020 ml (400-800 mg wa mankhwala) ) iv drip - masabata awiri ndikusintha kwa piritsi.

Zowonongeka za mtima (zotupa ndi venous) zamatsenga ndi zotsatira zawo. 20-30 ml (800-1200 mg wa mankhwalawa) mu 200 ml ya 0,9% sodium kolorayidi kapena 5% intravenous kapena intravenous dextrose solution tsiku lililonse, kwa milungu 4.

Matenda a shuga a polyneuropathy. 50 ml (2000 mg wa mankhwala) patsiku masabata atatu ndikusintha kwa mawonekedwe a piritsi - mapiritsi 2-3. Katatu patsiku kwa miyezi 4-5.

Kuchiritsa konse. 10 ml (400 mg ya mankhwalawa) iv kapena 5 ml IM tsiku lililonse kapena katatu pamlungu, kutengera njira yochira. Mwinanso mungagwiritse ntchito mitundu ya Actovegin ® yogwiritsira ntchito kunja.

Kupewa komanso kuchiza kuvulala kwama radiyo pakhungu ndi minyewa ya mucous pa radiation chithandizo. Mlingo wamba ndi 5 ml (200 mg) iv tsiku lililonse panthawi yopumira.

Mphamvu ya cystitis. Mosinthasintha, tsiku ndi tsiku, jakisoni 10 ml (400 mg) osakanikirana ndi mankhwala othandizira. Mulingo wa makonzedwe ndi pafupifupi 2 ml / min.

Kutalika kwa nthawi ya mankhwalawa kumatsimikiziridwa payekhapokha malinga ndi mawonekedwe ndi kuuma kwa matendawa.

Malangizo ogwiritsa ntchito ma ampoules omwe ali ndi mpata wopumira

1. Ikani nsonga ya phokoso ndi gawo logumukirako.

2. Kukoka pang'ono ndi chala ndikugwedeza zokwanira, lolani kuti yankho lake lithe kuchokera kumunsi kwa phokoso.

3. Dulani nsonga ya phokoso pamalo olakwika posamuka nanu.

Kutulutsa Fomu

Kubaya, 40 mg / ml.

Pankhani yopanga ndi kunyamula ku Takeda Austria GmbH, Austria:

2, 5, 10 ml ya mankhwalawa m'magalasi amtundu wopanda galasi wokhala ndi mpata wopumira. 5 amp iliyonse. mu pulasitala chida cholumikizira. 1, 2 kapena 5 matuza mumapaketi okhala ndi makatoni. Zolemba zoteteza kuzungulira zowonekera ndi zolemba za holographic ndi chiwongolero choyamba chotsegulidwa zimapakidwa pa paketi.

Pankhani yopanga ndi / kapena ma CD ku LLC Takeda Pharmaceuticals, Russia:

2, 5, 10 ml ya mankhwalawa m'magalasi amtundu wopanda galasi wokhala ndi mpata wopumira. 5 amp iliyonse. mu pulasitala chida cholumikizira chopangidwa ndi filimu ya polystyrene kapena filimu ya PVC. 1, 2 kapena 5 matuza mumapaketi okhala ndi makatoni. Zolemba zoteteza kuzungulira zowonekera ndi zolemba za holographic ndi chiwongolero choyamba chotsegulidwa zimapakidwa pa paketi.

Wopanga

Wopanga / wonyamula / Wowongolera chiwongolero chofunikira: Takeda Austria GmbH, Austria.

Art. Peter Strasse 25, 4020 Linz, Austria.

"Takeda Austria GmbH, Austria." Peter-Strasse 25, 4020 Linz, Austria.

Kapena LLC Takeda Mankhwala, 150066, Russia, Yaroslavl, ul. Technopark, 9.

Tele. ((495) 933-55-11, fakisi: (495) 502-16-25.

Kapena CJSC Pharmfirema Sotex. 141345, Russia, dera la Moscow, chigawo cha maseru a Sergiev Posad, madera akumidzi Bereznyakovskoe, pos. Belikovo, 11.

Tel./fax: (495) 956-29-30.

Bungwe lovomerezeka lomwe dzina lake limalembetsa chikalata: Takeda Pharmaceuticals LLC. 119048, Russia, Moscow, ul. Usacheva, 2, p. 1.

Tele. ((495) 933-55-11, fakisi: (495) 502-16-25.

[email protected], www.takeda.com.ru, www.actovegin.ru

Zodandaula za ogula ziyenera kutumizidwa ku adilesi yabungwe lovomerezeka lomwe dzina lawo lidulembera: Takeda Pharmaceuticals LLC, Moscow, Russia.

Zotsatira zoyipa

Kukula kwa zotsatira zoyipa kumatsimikizidwa malinga ndi gulu la Council of International Medical Science Scientities (CIOMS): pafupipafupi (≥ 1/10), nthawi zambiri (≥ 1/100 to ® sikuwonetsa zotsatira zoyipa ngakhale pamene mlingo uli wa 30-40 nthawi kuposa Mlingo wovomerezeka kuti ugwiritse ntchito mwa anthu Pakhala palibe milandu ya bongo ndi Actovegin ®.

Malangizo apadera

Zambiri zamankhwala
Mu ARTEMIDA multicenter, randomized, blind-blind, placebo-control) (NCT01582854), yomwe cholinga chake chinali kuphunzira zotsatira zakuchiritsa kwa Actovegin ® pakudziwitsika kwazidziwitso kwa odwala 503 omwe ali ndi ischemic stroke, zochitika zonse zovuta zowopsa ndi kufa zinali zofanana m'magulu onse awiri ochiritsira. Ngakhale ma pafupipafupi ma stropic a ischemic anali mkati mwazomwe zikuyembekezeredwa kwa odwala, kuchuluka kwa milandu kudalembedwa m'gulu la Actovegin ® poyerekeza ndi gulu la placebo, koma kusiyana kumeneku sikunali kofunikira kwambiri pazotsatira. Chiyanjano pakati pa omwe amachitidwa mobwerezabwereza ndi mankhwala ophunzirira sichinakhazikitsidwe.

Gwiritsani ntchito odwala odwala
Pakadali pano, momwe anthu angagwiritsire ntchito mankhwalawa Actovegin ® ana sapezeka, chifukwa chake kugwiritsa ntchito gulu la anthu sikofunikira.

Kukopa pa kuyendetsa galimoto komanso njira zina
Sanakhazikitse.

Packer / Kutulutsa Kuwongolera Kwabwino

Takeda G MBH, Germany
Lenitzstrasse 70-98, 16515 Oranienburg, Germany
Takeda GmbH, Germany
Lehnitzstrasse 70-98, 16515 Oranienburg, Germany
kapena
"Takeda Austria G MBH", Austria.
Art. Peter Strasse 25, 4020 Linz, Austria
Takeda Austria GmbH, Austria
St. Peter-Strasse 25, 4020 Linz, Austria
kapena
LLC Takeda Mankhwala
Russia, 150066, Yaroslavl, ul. Technopark, d.9,
kapena
CJSC Pharmheshama Sotex
Russia, 141345, Dera la Moscow,
Dera la maserikali a Sergiev Posad,
midzi yakumidzi Bereznyakovskoe, pos. Belikovo, 11.

Kutulutsa mafomu ndi kapangidwe kake

Mapapu okhala ndi madzi owoneka bwino kapena achikasu pang'ono a jakisoni.

Yogwira pophika: amozi wa hemoderivative, 40 mg / ml.

Yopangidwa ndi dialysis, kupatukana kwa nembanemba komanso kupatula magawo a magazi a nyama zazing'ono, odyetsedwa mkaka wokha.

Chowonjezera: madzi a jakisoni.

Itha kupangidwa ndi makampani opanga mankhwala Takeda Austria GmbH (Austria) kapena Takeda Pharmaceuticals LLC (RF). Atakulungidwa mu 2 ml, 5 kapena 10 ml mu galasi lopanda utoto la 5 ma PC. mumapangidwe okhala ndi pulasitiki opangidwa ndi pulasitiki. Maselo okhala ndi 1, 2 kapena 5 m'makatoni.

Mankhwala ndi a gulu la antihypoxants.

Pa paketi iliyonse yamakhadi pazikhala ndi zomata zozungulira zomwe zilembedwe za holographic ndikuwongolera kutsegulira koyamba.

Zomwe zimayikidwa

Actovegin 40 imaphatikizidwa mu mitundu yovuta kuchiza:

• zovuta zamavuto osiyanasiyana okondweretsa,
• zotumphukira zotupa za mtima ndi ngozi za mtima.
• zotumphukira angiopathy,
• matenda ashuga a m'mimba
• kusinthika kwa minofu (kuvulala, maopareshoni, zilonda zam'mimba zam'munsi, etc.),
• Zotsatira za mankhwala a radiation.

Kuphatikiza apo, pogwiritsa ntchito mawonekedwe awa, grositis yam'mimba, zilonda zam'mimba ndi duodenum amathandizidwa.

Actovegin 40 ndi gawo limodzi la mndandanda wamankhwala othandizira odwala mwangozi.
Mankhwala amapatsidwa matenda a shuga.
Pogwiritsa ntchito mawonekedwe awa, zilonda zam'mimba ndi duodenum zimathandizidwa.
Actovegin amagwiritsidwa ntchito pochiza zotsatira za mankhwala a radiation.

Momwe mungatenge Actovegin 40

Kutalika, Mlingo ndi mitundu ya mankhwala imatsimikizika potengera zomwe zimayambitsa matenda. Zimatsimikiziridwa payekhapayekha. Amawerengera kudzera m'mitsempha, mitsempha ndi intramuscularly.

Mankhwalawa metabolism ndi zotupa zam'mimba mu ubongo, pazigawo zoyambirira zamankhwala, 10-20 ml ya iv kapena iv amalowetsedwa tsiku lililonse. Kenako, malinga ndi dongosolo la mankhwalawo, 5 ml iv kapena IM ndi kuchepetsedwa kulowetsedwa.

Mu ischemic stroke mu pachimake siteji, mankhwala amathandizidwa.

Mu ischemic stroke mu pachimake siteji, infusions amachitidwa. Pachifukwa ichi, mankhwala (10-50 ml) amawonjezeredwa ku 200-300 ml ya kapangidwe ka isotonic (5% glucose kapena sodium chloride solution). Zitatha izi, mankhwalawa amasinthidwa kukhala piritsi la mankhwalawo.

Zochizira pazinthu zomwe zimayambika chifukwa cha kusokonezeka kwa minyewa yaubongo, mankhwalawa ndi mankhwala a iv kapena iv (20-30 ml ya mankhwalawa amaphatikizidwa ndi 200 ml ya kapangidwe ka isotonic).

Kuti athetse zizindikiro za matenda ashuga a polyneuropathy, 50 ml iv imalowetsedwa. Kenako achire zotsatira kusintha kwa Actovegin mapiritsi.

Ndi makonzedwe a / m, mpaka 5 ml amagwiritsidwa ntchito. Lowani pang'onopang'ono.

Kumwa mankhwala a shuga

Amatengera mankhwala omwe amathandizira kuti metabolism ikhale yachilendo. Chifukwa chake, ndizovomerezeka pakuchipatala.

Mankhwalawa amafunikira pakuchiza kwa matenda a shuga.

Bongo

Panalibe milandu yambiri ya Actovegin.

Amagwiritsidwa ntchito pochiza komanso kupewa hypoxic komanso vuto la ischemic la ziwalo ndi minyewa mwa odwala okalamba.

Pali kuthekera kowonjezereka kuwonekera kwa zoyipa.

Kuchita ndi mankhwala ena

Palibe zotsatira zoyipa chifukwa chogwiritsa ntchito mankhwala omwe adapezeka.

Zimagwirizana ndi mitundu ya mankhwala omwe amagwiritsidwa ntchito popanga zovuta za ischemic stroke (mwachitsanzo, ndi Mildronate).

Kuphatikiza apo, imagwiritsidwa ntchito pophatikizira ndi mankhwala omwe amagwiritsidwa ntchito kuti athetse venous ndi placental insufficiency, mankhwalawa a thrombosis (mwachitsanzo, ndi Curantil).

Kuphatikiza komwe kumafunikira kusamala

Kuphatikizidwa ndi ACE inhibitors (Enalapril, Lisinopril, Captopril, ndi zina), komanso kukonzekera kwa potaziyamu kumafunikira kusamala.

M'malo a Actovegin ndi:

• Vero-Trimetazidine,
• Curantil-25,
• Cortexin
• Cerebrolysin, etc.

Curantil-25 ndi analogue ya Actovegin.

Mtengo Actovegin 40

Mtengo wapakati umatengera kuchuluka kwa ma ampoules ndi kuchuluka kwawo phukusi. Chifukwa, mwachitsanzo, ku Russia, mtengo wa Actovegin (jekeseni wa 40 mg / ml ampoules a 5 ml 5 pcs.) Amasiyana kuchokera ma ruble 580 mpaka 700.

Ku Ukraine, phukusi lofananalo limawononga pafupifupi 310-370 UAH.

Mtengo wapakati wa mankhwalawa umatengera kuchuluka kwa ma ampoules ndi kuchuluka kwawo phukusi.

Ndemanga za madokotala ndi odwala pa Actovegin 40

Malingaliro a madokotala ndi odwala okhudzana ndi kugwiritsa ntchito, magwiridwe antchito ndi chitetezo amasiyana.

Vasilieva E.V., wamisala, Krasnodar

Actovegin ilibe zotsatira zoyipa ndipo imalekeredwa bwino. Itha kugwiritsidwa ntchito onse mu monotherapy komanso mu regimens zovuta. Wosankhidwa ndi pathologies a mtima dongosolo ndi metabolic zolephera. Ndikupangira odwala anga ambiri.

Marina, wazaka 24, Kursk

Anapereka jakisoni ndi ma donsi panthawi yoyembekezera kuti magazi azituluka. Palibe zoyipa. Pambuyo pa chithandizo, magazi amatuluka kukhala abwinobwino, ndipo kutopa ndi chizungulireko zidasowa limodzi ndi matendawa. Ndimalangiza azimayi onse oyembekezera.

Nefedov I.B., wazaka 47, Oryol

Ngakhale kuti mankhwalawa ndi oletsedwa ndi FDA (US Department of Health and Human Services), imagwiritsidwa ntchito kwambiri ku Russia ndi mayiko a CIS. Antigen wakunja. Sindikhulupirira mankhwalawa, malangizo omwe amawonetsa kuti ndizosatheka kuwunika malo ake a pharmacokinetic.

Afanasyev P.F. dokotala wa ultrasound, St.

Mankhwala abwino a antihypoxic osunga achire kwa miyezi 3-6. Chida ichi chimagwiritsidwa ntchito kwambiri kuchipatala chathu ku Research Institute. Ankylosing spondylitis yochotsa zizindikiro za matenda amisempha komanso matenda am'mimba otupa. Zimathandizira kuthetsa kupweteka kwa mutu, migraines, kumverera kwa nkhawa, kumapangitsa ntchito zamaganizidwe, etc.

Zizindikiro Actovegin ®

Monga mbali ya zovuta mankhwala:

• kusokonezeka kwa chizindikiritso, kuphatikizira kuwonongeka kozungulira
• zotupa zoyipa ndi zotulukapo zawo,
• matenda ashuga polyneuropathy.

Mlingo

Mankhwala amagwiritsidwa ntchito mu / a, mu / mu (kuphatikizapo mawonekedwe a kulowetsedwa) ndi / m.

Kutengera ndi kuopsa kwa chithunzichi, muyenera kuyika mankhwalawa kwa 10-20 ml tsiku lililonse kapena / tsiku lililonse, kenaka 5 ml mkati / kapena / m pang'onopang'ono, tsiku lililonse kapena kangapo pa sabata.

Mwa kulowetsedwa, kuchokera pa 10 mpaka 50 ml ya mankhwalawa akuyenera kuwonjezeredwa ku 200-300 ml ya yankho lalikulu (isotonic sodium chloride solution kapena 5% glucose solution). Mlingo wa kulowetsedwa uli pafupifupi 2 ml / min.

Kwa jakisoni wa v / m, osagwiritsa ntchito 5 ml ya mankhwalawa, omwe amayenera kuperekedwa pang'onopang'ono, chifukwa yankho lake ndi hypertonic.

Mu pachimake nthawi ischemic sitiroko (kuyambira masiku 5-7) - 2000 mg / tsiku mu / kutsitsa mpaka 20 infusions ndi kusintha kwa piritsi mawonekedwe 2 mapiritsi. 3 nthawi / tsiku (1200 mg / tsiku). Kutalika konse kwa mankhwala ndi miyezi 6.

Ndi dementia - 2000 mg / tsiku mu / kukapanda kuleka. Kutalika kwa chithandizo mpaka milungu 4.

Panthawi yamavuto obisika komanso zotulukapo zawo - 800-2000 mg / day in / a or in / in Drip. Kutalika kwa chithandizo mpaka milungu 4.

Pa matenda ashuga polyneuropathy - 2000 mg / tsiku iv / kukapanda kuleka 20 kulowetsedwa ndi kusintha kwa piritsi 3 mapiritsi. 3 nthawi / tsiku (1800 mg / tsiku). Kutalika kwa mankhwalawa kuyambira 4 mpaka 5 miyezi.

Malangizo ogwiritsa ntchito ma ampoules omwe ali ndi mpata wopumira

Ikani nsonga ya gawo lokwera.

Kugunda pang'onopang'ono ndi chala ndikugwedeza mphamvu, lolani kuti yankho lake lithe kuchokera kumunsi kwa phokoso.

Kugwira ampoule mdzanja limodzi ndikukweza mutu, ndi dzanja lina, kuthyola nsonga ya chikwanje pamalo olakwika.

Contraindication

• Hypersensitivity a mankhwala Actovegin ®, mankhwala omwewo kapena ochulukitsa,
• mtima wosakhazikika,
• pulmonary edema,
• oliguria, anuria,
• kuchuluka kwa madzi mthupi,
• ana ndi achinyamata ochepera zaka 18.