Hypolipidemic mankhwala Tricor - malangizo ntchito

Wothandizidwa ndi hypolipidemic pagulu la zotumphukira za fibroic acid.
Kukonzekera: TRICOR
The yogwira mankhwala: fenofibrate
ATX Encoding: C10AB05
KFG: Hypolipidemic mankhwala
Nambala yolembetsa: LSR-002450/08
Tsiku lolembetsa: 04/03/08
Mwini reg. ID.: Laboratoires FOURNIER S.A.

Kutulutsa Fricor Tricor, ma CD ndikuphatikizira ndi mankhwala.

Mapiritsiwo anali atakutidwa ndi filimu yoyera, yolembedwa "145" mbali imodzi ndi logo ya kampani inayo. Mapiritsi okhala ndi filimu 1 tabu. fenofibrate (micronized) 145 mg
Omwe amathandizira: sucrose, sodium lauryl sulfate, lactose monohydrate, crospovidone, microcrystalline cellulose, colloidal silicon dioxide, hypromellose, sodium docusate, magnesium stearate.
Kuphatikizika kwa Shell: Opadry OY-B-28920 (mowa wa polyvinyl, titanium dioxide, talc, soy lecithin, xanthan chingamu).
Ma PC 10 - matuza (1) - mapaketi a makatoni.
Ma PC 10 - matuza (2) - mapaketi a makatoni.
Ma PC 10 - matuza (3) - mapaketi a makatoni.
Ma PC 10 - matuza (5) - mapaketi a makatoni.
Ma PC 10 - matuza (9) - mapaketi a makatoni.
Ma PC 10 - matuza (10) - mapaketi a makatoni.
14 ma PC. - matuza (2) - mapaketi a makatoni.
14 ma PC. - matuza (6) - mapaketi a makatoni.
14 ma PC. - matuza (7) - mapaketi a makatoni.
Ma PC 10 - matuza (28) - makatoni ama katoni (ma CD a zipatala).
Ma PC 10 - matuza (30) - makatoni ama katoni (ma CD a zipatala).
Kufotokozera kwa mankhwalawa kumatengera malangizo ovomerezeka omwe angagwiritsidwe ntchito.

Pricorological kanthu Tricor

Wothandizidwa ndi hypolipidemic pagulu la zotumphukira za fibroic acid. Fenofibrate amatha kusintha zomwe zili mu lipid mu thupi la munthu kudzera mwa kutsegula kwa PPAR- receptors (alpha receptors yoyendetsedwa ndi peroxisome proliferator).
Fenofibrate imathandizira lipolysis ya plasma ndi kuchulukitsidwa kwa lipoprotein atherogenic yokhala ndi mawonekedwe apamwamba a triglycerides poyambitsa PPAR-α receptors, lipoprotein lipase ndikuchepetsa kaphatikizidwe ka apoprotein C-III. Zotsatira zomwe zafotokozedwa pamwambapa zimayambitsa kuchepa kwa zomwe zili pazigawo za LDL ndi VLDL, zomwe zimaphatikizapo apoprotein B (apo B), komanso kuwonjezeka kwa zomwe zili m'chigawo cha HDL, zomwe zikuphatikizapo apo A-I ndi apo A-II. Kuphatikiza apo, chifukwa cha kukonza kuphwanya kaphatikizidwe ndi katemera wa VLDL, fenofibrate imakulitsa kuwonekera kwa LDL ndikuchepetsa zomwe zimakhala ndi LDL yaying'ono (kuwonjezeka kwa LDL kumeneku kumawonedwa mwa odwala omwe ali ndi atherogenic lipid phenotype ndipo amagwirizana ndi chiwopsezo chachikulu cha CHD).
Pa maphunziro azachipatala, zidadziwika kuti kugwiritsa ntchito fenofibrate kumachepetsa cholesterol yonse ndi 20-25% ndi triglycerides ndi 40-55% ndi chiwonjezero cha HDL-C ndi 10-30%. Odwala omwe ali ndi hypercholesterolemia, momwe mulingo wa Chs-LDL amachepetsedwa ndi 20-35%, kugwiritsa ntchito fenofibrate kunapangitsa kutsika kwa ziwerengero: chonse Chs / Chs-HDL, Chs-LDL / Chs-HDL ndi pomwe B / apo A-I, omwe ali chizindikiro cha atherogenic chiopsezo.
Poganizira mphamvu ya fenofibrate pamlingo wa LDL-C ndi triglycerides, kugwiritsidwa ntchito kwa mankhwalawa kumagwira ntchito kwa odwala omwe ali ndi hypercholesterolemia, onse omwe amatsatana komanso osagwirizana ndi hypertriglyceridemia, mwachitsanzo, ndi hyperlipoproteinemia, mwachitsanzo, ndi mtundu wa 2 matenda osokoneza bongo. zowonjezera zowonjezera Xc (tendon ndi tubility xanthomas). Odwala omwe ali ndi milingo yambiri ya fibrinogen omwe amathandizidwa ndi fenofibrate, kuchepa kwakukulu kwa chizindikirocho kunadziwika, komanso kwa odwala omwe ali ndi milingo yayitali ya lipoprotein. Mankhwalawa fenofibrate, kuchepa kwa kuchuluka kwa mapuloteni a C omwe amachititsa kuti magazi azisungunuka ndi zina.
Kwa odwala omwe ali ndi dyslipidemia ndi hyperuricemia, mwayi wowonjezera ndikuti fenofibrate imakhala ndi uricosuric, zomwe zimapangitsa kuchepa kwa kuchuluka kwa uric acid ndi pafupifupi 25%.
M'maphunziro azachipatala komanso zoyeserera za nyama, fenofibrate yawonetsedwa kuti ichepetse kuphatikiza kwa platelet chifukwa cha adenosine diphosphate, arachidonic acid, ndi epinephrine.

Pharmacokinetics wa mankhwala.

Zogulitsa
Pambuyo pakukonzekera kwa pakamwa kwa Tricor, 145 mg ya Cmax imatheka pambuyo pa maola 2-4. Cmax mu plasma ndi mphamvu yonse ya michenized fenofibrate mu mawonekedwe a nanoparticles (Tricor 145 mg) osadalira kudya, chifukwa chake, mankhwalawa amatha kutengedwa nthawi iliyonse, mosasamala kanthu za kudya )
Kugawa
Fenofibroic acid ndi okhazikika komanso woposa 99% womangidwa ku plasma albin. T1 / 2 - pafupifupi maola 20. Mankhwalawa samadziunjikira pakatha nthawi yayitali komanso kugwiritsa ntchito nthawi yayitali.
Kupenda
Pambuyo pakukonzekera pakamwa, fenofibrate imatulutsidwa mofulumira ndi ma esterases. Yokha yogwira metabolite ya fenofibrate, fenofibroic acid, imapezeka mu plasma. Kugwiritsa ntchito kwa nthawi yayitali, kuchuluka kwa fenofibroic acid mu plasma kumakhazikika, osasamala kanthu za wodwalayo. Fenofibrate si gawo limodzi la CYP3A4, silikuchita nawo microsomal metabolism.
Kuswana
Amapakidwa makamaka ndi mkodzo mu mawonekedwe a fenofibroic acid ndi glucuronide conjugate. Pakupita masiku 6, fenofibrate imachotsedweratu pafupifupi.

Zambiri, kapangidwe ndi mawonekedwe ake amasulidwe

Malinga ndi radar, Tricor ndi mankhwala ochepetsa lipid - ochokera ku mafuta m'thupi. Kugwiritsa ntchito kwake kumathandizira kuchepetsa kuchuluka kwa mafuta m'thupi ndipo kumalepheretsa mapangidwe a atherosulinosis.

Kutulutsidwa kwake kumapangidwa ku France, pomwe mankhwalawa amagulitsidwa m'njira yam'mapiritsi. Zotsatira za mankhwalawa zimachitika chifukwa chake chimakhala chofunikira kwambiri, chomwe ndi fenofibrate.

Mutha kugwiritsa ntchito pokhapokha ngati adokotala adanenanso, chifukwa zimakhudza thupi. Zovuta zoyipa zambiri zimatha kugwiritsidwa ntchito mosayenera. Chifukwa chake, ndizotheka kugula kokha mwa mankhwala.

Kupanga ndalama kumachitika m'mapiritsi. Chofunikira chachikulu pa mankhwalawa ndi fenofibrate. Amaphatikizidwa ndi mapiritsi mu kuchuluka kwa 145 mg.

Kuphatikiza apo, pali zinthu monga:

• sucrose
• hypopellose,
• malingaliro a sodium,
• olimba ndi magnesium,
• cellcrystalline mapadi,
• lactose monohydrate,
• sodium laurisulfate,
• silicon dioxide colloidal.

Zinthu izi zimakupatsani mwayi wopatsa mankhwalawo mawonekedwe omwe mukufuna. Mapiritsiwa ndi filimu-wokutira (bp).

Palinso mapiritsi okhala ndi chophatikizira cha 160 mg. Muli ndizowonjezera zina monga mankhwala ena osiyanasiyana.

Mapaketi a mankhwala ali ndi masinthidwe osiyanasiyana. Atha kuphatikiza pa mapiritsi 10 mpaka 300 (mlingo wa 145 mg) kapena kuchokera 10 mpaka 100 zidutswa (mlingo wa 160 mg).

Pharmacological kanthu ndi pharmacokinetics

Kuti mumvetsetse chomwe mankhwalawa amapangidwira, muyenera kudziwa zomwe zachitika.

Fenofibrate imakhudzanso triglycerides, kuchepetsa kuchuluka kwawo. Zimathandizanso kuchepetsa cholesterol m'magazi. Izi ndichifukwa chakuphwanya kapangidwe ka mafuta acids.

Kugwiritsa ntchito mankhwalawa kumatha kuchepetsa kuchuluka kwa fibrinogen. Gawo lofooka pang'ono limagwira glucose, ndikuthandiza kuchepetsa mulingo wake. Izi zimapangitsa Tricor kukhala wothandiza pochiza odwala atherosulinosis omwe amakonda kudwala matenda ashuga.

Fenofibrate imafika pazomwe zimatha maola 5 pambuyo pa utsogoleri (izi zimasonkhezeredwa ndi machitidwe a thupi limodzi).

Kuchuluka kwake kumalumikizana ndi albumin, puloteni ya plasma, ndikupanga fenofibroic acid. Kagayidwe kake kumachitika m'chiwindi. Thupi limakhala ndi tanthauzo lokhalitsa - pafupifupi maola 20 amafunikira kuti athetse theka lake. Amachoka m'thupi kudzera m'matumbo ndi impso.

Zizindikiro ndi contraindication

Mutha kudziwa zomwe chida ichi chimathandizira pophunzira malangizo ndi zisonyezo pazolinga zake.

Ndikulimbikitsidwa kuti muzigwiritsa ntchito pazophwanya malamulo monga:

Ndi matenda otere, Tricorr imagwiritsidwa ntchito ngati njira zosagwiritsa ntchito mankhwalawa sizibweretsa zotsatira.

Komanso, adotolo atha kukulemberani mankhwalawa kuti athane ndi matenda ena monga gawo la zovuta mankhwala, ngati machitidwe otere ali oyenera.

Kumbukirani kuti kupezeka kwa zizindikiro za mankhwala sikutanthauza kugwiritsa ntchito mankhwalawa. Kuzindikira kwa ma contraindication kumakupangitsani kusiya kugwiritsa ntchito.

Izi zikuphatikiza:

• matenda oopsa a chiwindi
• mavuto akulu a impso
• tsankho pakuchokera,
• nyere
• matenda a gallbladder
• zaka za ana.

Palinso milandu yomwe kugwiritsa ntchito Tricor kumaloledwa, koma kumafuna kusamala kowonjezera:

• uchidakwa
• hypothyroidism
• ukalamba
• kuphwanya chiwindi ndi impso.

Izi zikutanthauza kuti mutha kumwa mankhwalawa pokhapokha mukauzidwa ndi katswiri. Kudzichitira nokha mankhwala kungayambitse zovuta.

Zisonyezero zogwiritsidwa ntchito:

- hypercholesterolemia ndi hypertriglyceridemia olekanitsidwa kapena osakanikirana (dyslipidemia mtundu IIa, IIb, IV) ndi kusagwira ntchito kwa mankhwala osagwiritsa ntchito mankhwala (hypolipidemic zakudya, kuchepa thupi, kuchuluka kwa zochitika zolimbitsa thupi) makamaka pakakhala matenda oopsa a dyslipidemia
- hyperlipoproteinemia yachiwiri, pomwe hyperlipoproteinemia imapitilirabe, ngakhale chithandizo chazomwe chimayambitsa matenda (mwachitsanzo, dyslipidemia mu shuga mellitus).

Mlingo ndi njira ya mankhwala.

Akuluakulu amayikidwa 1 tabu. 1 nthawi / tsiku
Odwala akutenga 1 kapu. fenofibrate 200 mg atha kupita ku 1 tabu. Tricorra 145 mg popanda kusintha kwa mlingo wowonjezera. Odwala akutenga tabu limodzi. fenofibrate 160 mg / tsiku, atha kutenga 1 tabu. Tricorra 145 mg popanda kusintha kwa mlingo wowonjezera.
Odwala okalamba amalangizidwa kuti apereke mlingo woyenera kwa akuluakulu.
Kugwiritsa ntchito mankhwalawa kwa odwala omwe ali ndi matenda a chiwindi sikunaphunzire.
Mankhwala Tricor 145 mg amatengedwa nthawi iliyonse ya tsiku, mosasamala kanthu za kudya, piritsi liyenera kumeza lonse, osafuna kutafuna, ndi kapu yamadzi.
Mankhwalawa amayenera kumwa kwa nthawi yayitali, ndikupitiliza kutsatira zakudya zomwe wodwalayo adatsata asanayambe chithandizo ndi Trikor.

Malangizo ogwiritsira ntchito

Njira Tricorum imagwiritsidwa ntchito kokha mkati. Mukamagwiritsa ntchito mankhwalawa muyezo wa 145 mg, mutha kumwa mosaganizira zakudya. Ngati muyezo wa 160 mg ndi mankhwala, mankhwalawa amayenera kumwedwa ndi chakudya. Sikoyenera kupera ndi kutafuna mapiritsi, ndikofunika kungosambitsa ndi madzi okwanira.

Mlingo ndi dongosolo la makonzedwe nthawi zambiri limayikidwa ndi katswiri ataphunzira za matenda ndi matendawo. Ngati zochitika zomwe zimafunikira kukonza kwake kulibe, wodwalayo akulimbikitsidwa kumwa mapiritsi a 145 kapena 160 mg (1 piritsi) patsiku.

Kutalika kwa nthawi ya maphunzirowa kumatsimikizidwanso payekhapayekha. Nthawi zambiri, zimatenga nthawi yayitali. Kuphatikiza apo, kudya kumalimbikitsidwa. Kuchita bwino kwa mankhwalawa kumatsimikiziridwa ndi zotsatira za mayeso kuti mudziwe kuchuluka kwa cholesterol ndi triglycerides.

Ngakhale mankhwalawa atalembedwa ndi katswiri, wodwalayo ayenera kuwunika mosamala kusintha kwake. Maonekedwe a zochita zoyipa kapena kusowa kwa tanthauzo kumatanthauza kuti Tricor sioyenera kuchita izi. Itha kuwonetsanso kufunika kwa kusintha kwa mlingo kapena kupezeka kwa ma contraindication obisika.

Kanema wonena za cholesterol ndi ntchito yake mthupi:

Odwala Apadera ndi Mayendedwe

Chiwerengero cha odwala omwe chisamaliro chapadera chimalimbikitsidwa pogwiritsa ntchito Tricor chimakhala m'magulu a anthu awa:

1. Amayi pa nthawi yoyembekezera. Zomwe zimagwiritsidwa ntchito ndi mankhwala zimatsutsana, motero, kugwiritsidwa ntchito koletsedwa panthawi imeneyi.
2. Amayi oyamwitsa. Zotsatira za fenofibrate pamkaka wa mkaka wa m'mawere ndi mwana sizinakhazikitsidwe. Pankhaniyi, madokotala sagwiritsa ntchito Trikor kwa odwala otere.
3. Ana. Osakwana zaka 18, mankhwalawa sagwiritsidwa ntchito, chifukwa sizikudziwika momwe kapangidwe kake kamakhudzira thupi la ana.
4. Anthu okalamba. Kwa gulu ili la odwala, kugwiritsa ntchito mankhwalawa kumawerengedwa kuti ndivomerezeka. Koma asanaikidwe, odwala amafunika kuwunika kuti apewe zovuta. Kuchepetsa Mlingo kumachitidwanso.

Anthu ena (pakalibe zotsutsana) amatha kugwiritsa ntchito mankhwalawa monga momwe adanenera dokotala.

Chenjezo liyenera kugwiritsidwa ntchito mukamagwiritsa ntchito Traicor pamaso pamavuto otsatirawa mthupi:

1. Matenda a impso. Mu matenda oopsa a chiwalo ichi, kugwiritsa ntchito mankhwalawo ndizoletsedwa. Kupatuka kochepa pakugwira ntchito kwa impso kumafunika kuwunikira nthawi yonse ya chithandizo ndikugwiritsa ntchito.
2. Matenda a chiwindi. Kwa mavuto ang'onoang'ono a chiwindi, dokotala atha kumuwonetsa Tricor atamuyeza. Zophwanya zazikulu ndi chifukwa chokana mankhwalawa.

Fenofibrate imatha kusintha magwiridwe antchito a chiwindi, chifukwa ngakhale osasokoneza malo ano, muyenera kupenda momwe zilili. Komanso, motsogozedwa ndi mankhwalawa, magawo a mapangidwe amwazi amatha kusintha - izi zimafunikiranso kuwongoleredwa.

Zotsatira zoyipa ndi bongo

Mukamagwiritsa ntchito Tricorr, zotsatira zoyipa zimatha kuchitika. Ndi chidwi chachikulu, muyenera kukana chithandizo ndi mankhwalawa.

Zotsatira zoyipa za mankhwalawa zimaphatikizapo:

• nseru
• mutu
• minofu kukokana
• kuchuluka kwa maselo oyera
• kuchuluka kwa mpweya,
• kutsegula m'mimba
• kupweteka m'mimba
• myositis
• urticaria
• kapamba
• kuyabwa
• zotupa pakhungu,
• ma gallstones
• alopecia
• kuchepa kugonana.

Ngati ndi kotheka, dokotala ayenera kuthana nawo. Palibe mankhwala enieni, chifukwa chake, odwala amapatsidwa chithandizo chamankhwala.

Milandu yama bongo osaneneka sichinalembedwebe. Akuti chithandizo chamankhwala chiyenera kuthandiza pozindikira.

Kuyanjana Ndi Mankhwala Ndi Analogi

Kuchita bwino kwa mankhwalawa kumaphatikizapo kuphatikiza koyenera kwa mankhwala omwe amagwiritsidwa ntchito. Ngati wina akonza zolakwika za wina, zotsatira zake zimakhala zosayembekezeka. Chifukwa chake, muyenera kuganizira momwe Tricor angakhudzire mankhwalawa omwe amagwiritsidwa ntchito limodzi nawo.

Kusamala kumafunika kuphatikiza mankhwalawa ndi:

• anticoagulants (fenofibrate amachepetsa mphamvu zawo, zomwe zimayambitsa ngozi yotulutsa magazi),
• Cyclosporine (ntchito ya impso imayipa),
• ma statins (pamakhala ngozi ya zovuta za m'misempha).

Kwa mankhwala ena, kusintha kwakukulu sikumawonedwa. Komabe, wodwalayo ayenera kudziwitsa dokotala za mankhwala onse omwe amagwiritsidwa ntchito kuti katswiriyo athe kukupatsani chithandizo choyenera.

Zifukwa zogwiritsira ntchito zida za analog zingasiyane. Nthawi zambiri, odwala amafunafuna ma analogi otsika mtengo, chifukwa kumwa mankhwala okwera mtengo mosalekeza ndi ntchito yotsika mtengo kwambiri.

Ena amakhala ndi nkhawa chifukwa cha zovuta zomwe zimapangitsa kuti zizikhala zovuta kugwira ntchito. Pankhaniyi, akatswiri nthawi zambiri amayenera kusankha mankhwala omwe ali ndi vuto lofananalo.

Izi zikuphatikiza:

Ndalama zina zomwe zatchulidwa zili ndi mtundu wofanana ndi wa Traicor. Kwa ena, zotsatira zofananira ndizodziwika, ngakhale zimasiyana zigawo zikuluzikulu.

Kuti mugwiritse ntchito analogue, muyenera kufunsa dokotala. Kudzipanga nokha kumakhala koopsa nthawi zonse, chifukwa chake muyenera kuwonetsetsa kuti mankhwalawo ndi abwino kwa wodwala wina.

Malingaliro odwala

Ndemanga za Tricor ya mankhwala ndizothandiza kwambiri - ambiri amazindikira kuti amapindulitsa bwanji thupi ndikuchepetsa cholesterol yamagazi.

Tawona Tricor miyezi isanu ndi umodzi yapitayo monga adanenera dokotala. Ndiyamika, adachotsa zowawa m'mapazi ndi mawondo. Magazi anga nawonso anachepa, ndipo ma triglycerides anga anachepa. Adamva bwino mpaka adasiya kumwa. Zizindikiro zonse zidabweranso, motero ndikuganiza zofunsa adokotala kuti apite kachiwiri.

Mankhwalawa adandithandiza kuthana ndi vuto la cholesterol yayikulu. Koma chifukwa cha iye, ndinayamba kudwala matenda ena - mwachidziwikire, mtundu wina wamavuto. Zinali zofunika kukana kugwiritsidwa ntchito.

Ndakhala ndikugwiritsa ntchito nyengoyi kwa miyezi itatu tsopano. Poyamba sizinali zabwino, kungofooka ndi mutu. Kenako chilichonse chinabweranso mwakale, mayesowa adakhala bwino. Ululu m'miyendo ndi manja nawonso unasiya, ndipo kukokana kunatha. Ndinkakonda kudzuka usiku chifukwa cha iwo, koma izi sizichitika. Ndimamva mphamvu zambiri - monga kuti ndimalimbikitsidwa.

Mtengo wa mankhwalawa umatengera muyeso wa mankhwala omwe ali nacho ndi kuchuluka kwa mapiritsi omwe ali phukusi. Phukusi lokhala ndi mapiritsi 30 (145 mg) muyenera kupereka kuchokera 750 mpaka 900 rubles. Pa mlingo wa 160 mg ndi phukusi lofananira, mtengo wa Tricor udzachokera ku 850 mpaka 1100 rubles.