Malangizo ogwiritsira ntchito mankhwalawa Neurorubin

Dzina lachi Latin: Neurorubine

Chosakaniza: Thiamine hydrochloride + Pyridoxine hydrochloride + Cyanocobalamin (Cyanocobalamin + Thiamine hydrochloridum + Pyridoxine hydrochloridum)

Wopanga: Wepha GmbH (Germany)

Kufotokozera kwadutsika pa: 02/05/18

Neurorubin ndi mavitamini ovuta pokonzekera mankhwalawa.

Kutulutsa mawonekedwe ndi kapangidwe kake

Neurorubin amagulitsidwa mwanjira yothetsera jakisoni ndi mapiritsi okhala ndi matendawa.

Njira yothetsera vutoli imapezeka m'magalasi okhala ndi makatoni a 5 amp.

Mapiritsi okhala ndi matenga amapezeka m'matumba (mapiritsi 10 aliyense), omwe amaikidwa m'mabhokisi a 2 pcs.

Zizindikiro zogwiritsidwa ntchito

Zisonyezero zogwiritsidwa ntchito ndi matenda awa:

• Matenda a shuga a polyneuropathy.
• Zilonda zamanjenje zamanjenje ndi neuralgia yomwe imayamba chifukwa cha poyizoni ndi zinthu zosiyanasiyana, kuphatikizapo mankhwala osokoneza bongo komanso zakumwa zoledzeretsa.
• Ululu wambiri ndi pachimake mitundu ya polyneuritis ndi neuritis.

Yankho la jakisoni

Ntchito ngati monotherapy kapena molumikizana ndi mankhwala ena a matenda otere:

• Anthu odwala matenda ashuga polyneuropathies.
• Neuropathies (kuphatikizapo zotumphukira, zopsinjidwa ndi mowa).
• Neuralgia, kuphatikizapo trigeminal neuralgia ndi cervicobrachial neuralgia.
• Acute ndi matenda polyneuritis pachimake ndi neuritis osiyanasiyana etiologies.
• Mawonekedwe owuma komanso owuma a Beriberi (mkhalidwe womwe umachitika ndikusowa thiamine), vitamini B hypovitaminosis

Contraindication

Contraindication kuti agwiritse ntchito ndi hypersensitivity kwa zigawo zogawo. Njira ya Neurorubin sagwiritsidwa ntchito panthawi yobala mwana komanso yoyamwitsa, komanso pochiza ana osaposa zaka 16.

Mankhwala amatchulidwa mosamala kwambiri odwala omwe ali ndi psoriasis. Kuchepetsa kumeneku kumalumikizidwa ndi kuthekera kwa cyanocobalamin kukulitsa psoriasis.

Zotsatira zoyipa

Kugwiritsa ntchito mankhwala Neurorubin kungayambitse zotsatirazi:

• Pakati ndi zotumphukira mantha dongosolo: chizungulire, kupweteka mutu, kufooka. Nthawi zina, pamakhala nkhawa, kuchuluka kwa mkwiyo ndi nkhawa. Pogwiritsa ntchito mankhwalawa muyezo waukulu, n`zotheka kukulitsa zotumphukira za m'mitsempha, zomwe zimazimiririka atasiya kumwa mankhwala.
• Mtima dongosolo: kuzungulira kwa magazi (omwe amapezeka mwa anthu omwe ali ndi hypersensitivity ku zigawo zikuluzikulu za mankhwala), tachycardia.
• Matumbo dongosolo: Kuukira mseru, kuchuluka chiwindi michere mu magazi, kusanza. Odwala omwe ali ndi hypersensitivity kwa mankhwalawa, magazi am'mimba amachitika.
• Mawonekedwe a matupi awo: urticaria, totupa ndi kuyabwa kwa khungu. Mukamamwa Mlingo waukulu wa mankhwalawa, kukula kwa ziphuphu zakumaso kumawonedwa.
• Zina: cyanosis, kutuluka thukuta, pulmonary edema. Odwala omwe ali ndi vuto la hypersensitivity ku mankhwalawa ali ndi chiopsezo chokhala ndi anaphylactoid zimachitika (kuphatikizapo edema ya Quincke). Kugwiritsa ntchito kwa makolo mwa odwala omwe ali ndi hypersensitivity ku mavitamini B, pamakhala chiopsezo cha anaphylactic.

Zotsatira za pharmacological

Neurorubin ndi njira yovuta yokonzekera mavitamini yomwe ili ndi mavitamini osungunuka a madzi a B. Imakhala ndi zochitika zosiyanasiyana zachilengedwe.

Vitamini B1 imakhudzanso kagayidwe kazakudya, pakupanga ndi kusinthana kwa amino acid, motero kuyang'anira kagayidwe kazakudya zomanga thupi. Mu metabolism yamafuta, vitamini B1 amawongolera mapangidwe a mafuta acids ndipo amathandizira kusintha kwa mafuta kukhala mafuta. Mitundu yogwira ya vitaminiyo imapangitsa kuti matumbo asamayende bwino komanso chinsinsi. Vitamini B1 imayendetsa mayendedwe a ion mu cell membrane ya neurons, ikukhudzana ndi kutsika kwa zophatikizika muzinthu za mitsempha.

Vitamini B6 amatenga nawo gawo mu kapangidwe ka michere, mapuloteni ndi mafuta kagayidwe, amagwira nawo ntchito zosiyanasiyana za enzymatic pamaudindo a coenzyme. Imayang'anira kaphatikizidwe ka ma neurotransmitters mu ma synapses apakati ndi zotumphukira, amatenga nawo mbali pakapangidwe ka myelin membrane wa neurons, mu lipid ndi protein metabolism, ndikuwongolera kaphatikizidwe ka hemoglobin.

Vitamini B12 imagwira ntchito yofunika kwambiri mumapuloteni, imayendetsa kapangidwe ka amino acid, purines ndi ma nucleic acid. Ndikofunikira kwa yachibadwa njira ya neuronal myelination ndi mapangidwe acetylcholine. Imathandizira kuwongolera bwino kwa kukhudzidwa kwa mitsempha paliponse pazomwe zimapangidwa ndi mitsempha yaziphuphu ndikuthandizira kukonzanso kwa ulusi wamitsempha. Cyanocobalamin ali ndi hematopoietic kwenikweni, imapangitsa erythropoiesis, imayendetsa hematopoiesis, imasintha magazi pakupanga magazi, komanso imathandiza kuchepetsa cholesterol m'magazi.

Neurorubin imakhala ndi mitundu yayikulu ya mavitamini omwe ali pamwambawa, omwe mwa zovuta amapangitsa kuti ntchito yamanjenje ikhale yokhudza lipid, chakudya, mapuloteni komanso mapuloteni. Kuphatikiza kwa mavitamini a B kumathandizira kuchepetsa ululu ndi neuralgia yamayendedwe osiyanasiyana.

Malangizo apadera

The yogwira zinthu za yankho ndi mapiritsi kudutsa hematoplacental chotchinga ndi kudutsa mkaka wa m'mawere. Palibe chidziwitso cha chitetezo chogwiritsidwa ntchito panthawi yoyembekezera komanso mkaka wa m`mawere. Chifukwa chake, atha kutumizidwa ndi dokotala ngati chiopsezo chomwe chingakhalepo kwa mwana wosabadwa chiri chocheperako kuposa phindu lomwe amayembekezera mayi. Ngati pakufunika kupereka mankhwala pa yoyamwitsa, m`pofunika kuthetsa nkhani yosiya kuyamwa.

Kuyanjana kwa mankhwala osokoneza bongo

Mukamagwiritsidwa ntchito limodzi, neurorubin amachepetsa njira yothandizira ya levodopa. Izi ziyenera kuganiziridwa pochiza anthu omwe ali ndi matenda a Parkinson. Ndikulimbikitsidwanso kupewa kugwiritsa ntchito mankhwalawa munthawi yomweyo.

Ndi zovuta kugwiritsa ntchito, mankhwalawa amathandizira poizoni wa isoniazid.

Mankhwala omwe ali ndi antacid komanso enveloping katundu amachepetsa mayamwidwe (mayamwidwe) a Neurorubin.

Chifukwa cha vitamini B6, yomwe ndi gawo lokonzekera, imatha kuchepetsa kugwiritsidwa ntchito kwa altretamine mukamagwiritsa ntchito limodzi.

Mtengo mumafakisi

Mtengo wa Neurorubin phukusi limodzi limayamba ku ruble 500.

Malongosoledwe patsamba lino ndi mtundu wosavuta wa mtundu wazovomerezeka zamankhwala. Chidziwitsocho chimaperekedwa kuti chizidziwitso chokha komanso sikuti chitsogozo chodzidziwitsa nokha. Musanagwiritse ntchito mankhwalawa, muyenera kufunsa katswiri kuti mudziwe malangizo omwe amavomerezedwa ndi wopanga.

Mankhwala

Kuphatikizika kwa mankhwala osokoneza bongo a Vitamini kuli ndi zinthu monga pyridoxine, cyanocobalamin ndi thiamine. Chilichonse mwazinthu izi zimafunidwa kuti zizichita mosiyanasiyana mu thupi la munthu.

Mwachitsanzo, thiamine amagwira nawo ntchito pazochita za metabolic zokhudzana ndi mafuta ndi ma carbohydrate (koma osati mapuloteni). Kuperewera kwa thiamine kumabweretsa kuwonjezeka kwamakhalidwe a lactate ndi pyruvic acid. Pulogalamu yothandiza iyi imalimbikitsa kukonzanso, komanso kusinthana kwa ma amino acid ofunikira m'thupi.

Chifukwa cha njirazi zomwe zikuchitika ndi gawo la thiamine, metabolism ya protein imakhazikika. Tiyenera kukumbukira kuti chinthucho chimathandizira kagayidwe kazakudya ndikupanga mafuta acids, ndikuphatikiza apo zimapangitsa kuti ntchito yamatumbo ikhale m'matumbo pamodzi ndi motility, kuwonjezera, Vitamini amalumikizana ndi makoma a cell mkati mwa ma neurons ndikuwonjezera ntchito ya njira za ion.

Pyridoxine, monga thiamine, amatenga nawo gawo pamafuta ndi mapuloteni am'magazi, ndipo amamangiriza ma enzyme nawo. Gawoli ndi coenzyme pakukula kwa enzymatic reaction. Vitamini A amathandizira kupanga khoma la myelin neural ndipo amatenga nawo gawo pakusinthana kwa lipids ndimapuloteni, komanso, pakuphatikiza kwa hemoglobin ndi neurotransmitters mkati mwa ma synapses a chapakati mantha dongosolo, komanso PNS.

Cyanocobalamin ndiyofunikira kwambiri mu metabolism ya protein, ndipo nthawi yomweyo imayang'anira kapangidwe ka purines ndi nucleic acid ndi amino acid. Vitamini iyi ndiyofunikira kwa thupi, chifukwa imakhudza kupanga acetylcholine, komanso kuwonjezera pa mapangidwe a neural myelination. Komanso, gawo ili limakhudza bwino kubwezeretsa kwa ulusi wamanjenje ndipo limalimbikitsa kukulitsa zovuta mkati mwa zotumphukira za NS.

Vitamini ali ndi hematopoietic kwenikweni, amawongolera cholesterol ndipo, nthawi yomweyo, amathandizira erythropoiesis. Cyanocobalamin imathandizira kukonza njira za hematopoietic komanso kukhazikika kwa magazi.

Kuphatikiza apo, mavitamini onse omwe ali pamwambawa amathandizira kukhazikika kwa ntchito ya NS ya anthu ndipo nthawi yomweyo amakhala ndi zotsatira zabwino pa kagayidwe ka lipids okhala ndi mapuloteni, zakudya ndi mafuta.

Ndikofunikanso kuganizira kuti mavitamini oterewa amachepetsa kwambiri kupweteka komwe kumachitika chifukwa cha mitsempha yomwe imakhala ndi mitundu yosiyanasiyana.

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Pharmacokinetics

Mavitamini osungunuka m'madzi amatha bwino kumeza pambuyo pamankhwala, ma cellacokinetic ena:

• vitamini b₁: Gawo la diamine lomwe linaphatikizidwa limakhudzidwa ndi kufalitsidwa kwa magene acid. Zosasinthika, thiamine imachotsedwa mu zochepa, zimapukusidwa mu mawonekedwe a metabolites: thiamincarboxylic acid ndi piramidi (2,5 dimethyl-4-aminopyrimidine),
• vitamini b₆: pyridoxine imapangidwa kuti ikhale pyridoxamine kapena oxidized kuti pyridoxal; monga coenzyme, pyridoxine imagwira ntchito ngati pyridoxal-5-phosphate (PALP) chifukwa cha phosphorylation wa CH₂Gulu la OH muudindo wachisanu, mpaka 80% PALF imamanga mapuloteni a plasma, pyridoxine mu mawonekedwe a PALF imadziunjikira makamaka mu minofu minofu, yotulutsidwa makamaka mu mawonekedwe a 4-pyridoxic acid,
• vitamini b₁₂: Pambuyo mayamwidwe, cyanocobalamin mu seramu imagwira makamaka ndi mapuloteni - enieni B₁₂-kubweretsa β-globulin (transcobalamin) ndi B₁₂-kuphatikiza cy1-globulin, vitamini B adapangidwa₁₂ kwambiri mu chiwindi, theka-moyo (T_1/2) kuchokera ku seramu yamagazi

Masiku 5, ndi chiwindi

Kuchita

Sitikulimbikitsidwa kuti mutenge pamodzi neurorubin, Levodopa ndi Altretamine, popeza vitamini ovutikayo amachepetsa mphamvu ya mankhwala omwe ali pamwambapa. Kuti mupewe kuwonjezereka kwa kawopsedwe Isoniazid osagwiritsa ntchito mankhwalawa komanso zovuta nthawi imodzi Mavitamini B.

Ndikofunika kukumbukira kuti Vitamini B1 Otsutsa ndi zinthu monga Pikachat, komanso kachikachiyama. Mafuta Neurorubin Forte Lactab chepetsa mankhwala ndi katundu waacacidndi kupereka enveloping zotsatira.

Pa mimba ndi mkaka wa m`mawere

Popeza deta pa chitetezo chathunthu cha woyembekezera ndipo palibe azimayi amiyala, Neurorubin amaletsedwa kugwiritsa ntchito munthawi yomwe ili pamwambapa. Komabe, dotolo yemwe akupezekapo amatha kupereka mankhwala a vutoli kwa mayi woyembekezera ngati akufunika thandizo la kuchipatala pokhapokha ngati akuyembekeza kuti phindu lomwe lingapezeke lidzakhala lalitali kwambiri kuposa vuto lomwe lingachitike.

Ngati ndi kotheka, ntchito neurorubin nthawi nyereNdikulimbikitsidwa kuti muime yoyamwitsamonga kulumikizana kumathachotchinga hematoplacental ndikusintha kapangidwe ka mkaka wa m'mawere, womwe umatha kusokoneza thanzi la mwana.

Kodi mankhwalawa amapatsidwa nthawi yanji?

Zizindikiro zazikulu zogwiritsidwa ntchito:

• Wernicke-Korsakoff matenda, zotumphukira neuropathy ndi zina zomwe zimachitika chifukwa cha uchidakwa,
• valani mtundu wouma ndi wonyowa,
• matenda ashuga polyneuropathy.

Monga gawo la mankhwala othandizira, amagwiritsidwa ntchito:

• pachimake komanso matenda am'mimba komanso polyneuritis,
• cervicobrachialgia ndi trigeminal neuralgia.

Kuletsa kwa mankhwala

Milandu yomwe mankhwalawa ndi oopsa pochiza odwala:

1. Mtsutso waukulu womwe umachitika pakumwa mankhwalawa ndi kudziwa komwe kumapangitsa thupi, makamaka vitamini B6.
2. Vitamini B12 simalimbikitsidwa kwa anthu omwe ali ndi psoriasis, chifukwa imatha kupangitsa kuti matenda awonongeke.
3. Osagwiritsa ntchito mankhwalawa amayi apakati ndi amayi oyamwitsa. Zina mwazinthu zotsutsana ndi zaka za ana.

Mlingo ndi njira yoyendetsera

Muzochitika zapamwamba, mankhwala a Neurorubin amapatsidwa mankhwala amodzi tsiku lililonse tsiku lililonse kuti muchepetse mawonetseredwe a ululu. Malingaliro otere amayembekezeredwa kumayambiriro kwa chithandizo. Pambuyo pake, odwala amapatsidwa ma ampoules a 1-2 nthawi kawiri pa sabata.

Njira Yogwiritsira Ntchito:

1. Tengani zochulukirapozo ndikuyika chizindikiro. Amawonetsedwa ngati kadontho.
2. Gwedezani bwino kuti madzi agawire wogawana.
3. Dulani mutu wazopangidwazo zomwe zimakhala pamwamba polemba.

Kuthekera kwa bongo

Kutenga Mlingo wambiri wa vitamini B6 pazowonjezera 500 mg kapena kupitilira miyezi isanu kungayambitse zovuta. Mankhwala osokoneza bongo nthawi zambiri amakhala ndi:

• thupi lawo siligwirizana
• zotumphukira zosinthira zamatsenga.

Neuropathy nthawi zambiri imatha pambuyo posiya mankhwala.

Zotsatira zoyipa

Kumwa mankhwalawo kumatha kukhala limodzi ndi zovuta izi:

1. Endocrine dongosolo: chopinga cha prolactin magwiritsidwe.
2. Matenda a chitetezo cha mthupi: kawirikawiri - matupi amtundu wa polymorphic erythema, angioedema, omwe amakhala ndi chidwi ndi anthu omwe ali ndi chidwi ndi zigawo zina za mankhwala. Nthawi zina, jakisoni wambiri wa mavitamini atagundika, amayamba kugwedezeka. Chithandizo chaimpawu chimaphatikizanso kugwiritsa ntchito antihistamines.
3. Matenda a mtima: pulmonary edema yomwe imapezeka mwa anthu omwe ali ndi chidwi ndi zigawo zina, cyanosis, tachycardia ngakhale kugwa ndizotheka.
4. Pa khungu: urticaria ndi kuyabwa, zomwe zimadziwika munthu aliyense payekha. Ziphuphu zimapezeka mwa odwala omwe apatsidwa kuchuluka kwa mankhwalawa. Pyridoxine imadzetsa mawonekedwe a ziphuphu zatsopano, komanso kufalikira kwa ziphuphu kumaso.
5. Zotsatira wamba: kufooka, chizungulire, thukuta.

Odwala nthawi zambiri amakhala ndi nkhawa atatenga Neurorubin. Mwa makanda omwe ali ndi vuto la vitamini B12, milandu yosuntha mosalekeza inalembedwa pambuyo pa chithandizo.

Mitu ya mankhwalawa

Mwa analogues ayenera kumvetsetsa mankhwala omwe ali ndi dzina lofananira, lomwe si logwirizana ndi mayiko ena onse. Ndikofunikira kumvetsetsa kuti musanalowetse Neurorubin ndi analogue, muyenera kufunsa dokotala. Zofanizira zazikulu:

1. Vitaxon. Amagwiritsidwa ntchito pakuchepa kwa mavitamini B1 ndi B6 othandiza pothana ndi matenda amitsempha.
2. Neurobion. Ntchito mankhwalawa neuralgia neuralgia, kuphatikizapo trigeminal neuralgia, intercostal neuralgia. Zina mwazomwe zikuwonetsa ndi radicular neuritis, kusintha kwina komwe kumakhudzana ndi kusinthika kwa msana, prosoplegia, ndiko kuti, vuto lakumaso.
3. Neuromax. Neologicalological pathologies omwe amagwirizana ndi kuperewera kwa mavitamini B1 ndi B6.
4. Neuromultivitis. Ndiwothandiza kwa polyneuropathy, matenda amitsempha am'mayendedwe osiyanasiyana, neuralgia ndi neuritis, radiculoneuritis yopangidwa chifukwa cha kusokonekera kwa kapangidwe ka msana, ndi kufooka kwa khomo lachiberekero, sciatica, intercostal neuralgia.
5. Nerviplex. Zina mwazomwe zikuwonetsa ndi kuchepa kwa mavitamini B1, B6, B12, matenda ashuga a m'mimba, neuralgia, nkhope ya nerve paresis, mitsempha ya m'mitsempha yosiyanasiyana.
6. Neurobeks. Amagwiritsidwa ntchito posintha kwazovuta m'mitsempha yamafumbi, matenda osakhazikika omwe amachitika chifukwa cha kusintha kwa thupi chifukwa cha matenda ashuga, wothandizila, komanso zakumwa zoledzeretsa. Zina mwazomwe zikuwonetsa ndi polyneuropathies, osteochondrosis, sciatica, lumbago, kuvulala koopsa, vegetovascular dystonia. Amagwiritsidwa ntchito pophatikiza mankhwala a vitamini B1, B6, B12 hypovitaminosis, omwe ali ndi khungu. macular alibe, pruritus wa osiyanasiyana etiologies.
7. Unigamm Ntchito mu mawonekedwe a matenda a minyewa matenda osiyanasiyana osiyanasiyana. Ichi ndi chida chothandiza polimbana ndi matenda osokonezeka a msana, khomo lachiberekero, lumbago.

Mtengo wamitundu yosiyanasiyana yamasulidwe:

1. Mapiritsi okhala ndi Neurobion ophatikizidwa pazidutswa 20 phukusi lililonse limagulidwa pamtengo wapakati wa rubles 280-300.
2. Njira yothetsera jakisoni wambiri wam'mapapo atatu a 3 mg ndikugulitsanso. Mtengo wawo ndi pafupifupi ma ruble 280.

Zotsatira zoyipa

• Mgwirizano wamtima: munthawi zina - kugwa, tachycardia, cyanosis,
• Pakati mantha dongosolo: nkhawa, kunjenjemera, kumva ngati "kupindika pakhosi", nkhawa, chizungulire,
• Matumbo a dongosolo: nseru, kutuluka kwa m'mimba, kuchuluka kwa plasma ya aspartate aminotransferase,
• Endocrine dongosolo: chopinga cha prolactin excretion,
• Njira yodzikonzera: edema ya m'mapapo, kupuma movutikira,
• Khungu: Ziphuphu,
• Zotsatira zamagetsi: kuyabwa, urticaria, edema ya Quincke, kuwopsa kwa anaphylactic,
• Thupi lonse: kumverera kufowoka, thukuta ladzidzidzi, Hyperemia ya nkhope, malungo.

Bongo

Mankhwala osokoneza bongo a Neurorubin amalimbitsa monga chizindikiro cha mavuto monga arrhythmia, chizungulire, kupweteka.

Zotheka kuchita ngati mukupezeka mankhwala osokoneza bongo ambiri a B:

• vitamini b₁: chifukwa cha kuchuluka kwa mankhwalawa kwa thiamine, pamene imwedwa muyezo waukulu (zoposa 10,000 mg), kutsitsa kwa mitsempha kumapanikizidwa, kuwulula zotsatira za curariform,
• vitamini b₆: pyridoxine ali ndi poizoni wotsika kwambiri, koma kugwiritsidwa ntchito kwake pamlingo wambiri (oposa 1000 mg patsiku) kungawonetse vuto la miyezi ingapo, pambuyo pa utsogoleri wa tsiku ndi tsiku woposa 2000 mg, zomwe zimachitika ngati neuropathy ndi ataxia ndi vuto la kumva. matenda a ubongo amagwiritsa ntchito kusintha mu electroencephalogram, munthawi zina, seborrheic dermatitis ndi hypochromic anemia
• vitamini b₁₂: parenteral makonzedwe a cyanocobalamin mu Mlingo wopitilira zomwe analimbikitsa, hypersensitivity zimachitikira, mawonekedwe oyipa a ziphuphu zakumaso ndi mawonekedwe a khungu oziziridwa amawonetsedwa kawirikawiri, kugwiritsa ntchito nthawi yayitali kungayambitse vuto la chiwindi michere, kuchepa kwa mtima, kupweteka mumtima.

Ngati mukukayikira kuti mulingo wovomerezeka udapitilira, ntchito ya Neurorubin iyenera kusiyidwa ndipo ngati kuli koyenera, chithandizo chazizindikiro ziyenera kuchitika.