Torvacard: malangizo ogwiritsira ntchito, zikuwonetsa, malingaliro ndi ma fanizo

Munkhaniyi, mutha kuwerengera malangizo ogwiritsira ntchito mankhwalawa Thorvacard. Ndemanga za alendo pamalowa - ogula mankhwalawa, komanso malingaliro a akatswiri azachipatala pakugwiritsa ntchito Torvacard statin machitidwe awo amaperekedwa. Chopempha chachikulu ndikuti muwonjezere ndemanga zanu za mankhwalawa: mankhwalawo adathandizira kapena sanathandizire kuchotsa matendawa, ndizovuta ziti zomwe zimawoneka ndi zotsatirapo zake, zomwe mwina sizinalengezedwe ndi wopanga. Analogs a Torvacard pamaso pa maupangidwe ena apangidwe. Gwiritsani ntchito kuchepetsa mafuta m'thupi komanso kupewa matenda a mtima mwa akulu, ana, komanso panthawi yoyembekezera.

Thorvacard - lipid-kutsitsa mankhwala ku gulu la ma statins. Kusankha mpikisano wosankha wa HMG-CoA reductase, enzyme yomwe imatembenuza 3-hydroxy-3-methylglutaryl-coenzyme A mpaka mevalonic acid, yomwe imatsogolera sodiumids, kuphatikiza cholesterol. Mu chiwindi, triglycerides ndi cholesterol imaphatikizidwa mu VLDL, imalowa m'magazi am'magazi ndipo imatengedwa kupita ku zotumphukira. Kuchokera ku VLDL, LDL imapangidwa panthawi yolumikizirana ndi LDL receptors. Atorvastatin (zomwe zimagwiritsidwa ntchito ndi mankhwala a Torvard) amachepetsa plasma cholesterol (Ch) ndi lipoproteins poletsa HMG-CoA reductase, kupanga cholesterol m'chiwindi ndikuwonjezera kuchuluka kwa zolandila za LDL m'chiwindi pamaselo a khungu, zomwe zimapangitsa kuti pakhale kuchuluka ndi chidwi chachikulu cha LDL .

Atorvastatin imachepetsa mapangidwe a LDL, imayambitsa kuwonjezereka komanso kulimbikira mu zochitika za LDL receptors. Torvacard amachepetsa LDL odwala omwe ali ndi homozygous Famer hypercholesterolemia, yomwe nthawi zambiri siziwathandiza kuchiza ndi ena othandizira a hypolipidemic.

Amachepetsa kuchuluka kwa cholesterol yonse ndi 30-46%, LDL - mwa 41-61%, apolipoprotein B - ndi 34-50% ndi triglycerides - pofika 14-33%, amachititsa kuchuluka kwa HDL-C ndi apolipoprotein A. Dose-modalira kumachepetsa mulingo wa LDL mu odwala homozygous cholowa hypercholesterolemia, kugonjetsedwa ndi mankhwala ndi lipid-kuchepetsa mankhwala.

Kupanga

Calcium a Atorvastatin.

Pharmacokinetics

Mafuta ndi okwera. Kudya pang'ono kumachepetsa kuthamanga ndi kutalika kwa mankhwalawa (mwa 25% ndi 9%, motsatana), koma kuchepa kwa cholesterol ya LDL kuli chimodzimodzi ndi kugwiritsidwa ntchito kwa atorvastatin popanda chakudya. Kuchulukitsidwa kwa atorvastatin pamene ntchito madzulo kumatsika kuposa m'mawa (pafupifupi 30%). Ubale wapakati pakati pa kuchuluka kwa mayamwidwe ndi mlingo wa mankhwalawo unawululidwa. Zimapangidwa makamaka m'chiwindi. Imafufutidwa m'matumbo ndi bile pambuyo pa hepatic ndi / kapena extrahepatic metabolism (siyimatchulidwa kuti enterohepatic recirculation). Ntchito yoletsa kutsutsana ndi HMG-CoA reductase imangokhalira kwa maola 20-30 chifukwa cha kukhalapo kwa metabolites yogwira. Osakwana 2% ya mlingo wa pakamwa amadziwika mu mkodzo. Sichotsetsedweratu pa hemodialysis.

Zizindikiro

• kuphatikiza ndi zakudya kuti muchepetse kuchuluka kwa cholesterol okwanira, cholesterol-LDL, apolipoprotein B ndi triglycerides ndikuwonjezera cholesterol-HDL kwa odwala omwe ali ndi hypercholesterolemia, heterozygous mabanja ndi osagwirizana ndi hyperlipidemia (mitundu 2a ndi 2a ndi 2a ,
• kuphatikiza ndi zakudya zochizira odwala omwe ali ndi serum triglycerides (mtundu 4 malinga ndi Fredrickson) ndi odwala dysbetalipoproteinemia (mtundu 3 malinga ndi Fredrickson), yemwe mankhwalawa amadya.
• Kuchepetsa kuchuluka kwa cholesterol yathunthu ndi LDL-C odwala omwe ali ndi homozygous Famer hypercholesterolemia, pamene chithandizo chamankhwala ndi njira zina zosagwiritsa ntchito mankhwalawa sizigwira ntchito mokwanira (monga njira yolumikizira kuchepa kwa lipid-kupatula magazi, kuphatikizapo autohemotransfusion ya magazi-oyeretsedwa a LDL),
• Matenda a mtima ), kuphatikizapo motsutsana ndi maziko a dyslipidemia - yachiwiri prophylaxis ndi cholinga chochepetsera chiopsezo chonse cha kufa, kulowerera m'matumbo, sitiroko, kuyambiranso kuchipatala kwa angina pectoris ndi kufunika kosintha njira.

Kutulutsa Mafomu

10 mg, 20 mg ndi 40 mg mapiritsi okhala ndi mafilimu.

Malangizo ogwiritsira ntchito ndi regimen

Torvacard asanaikidwe, wodwalayo ayenera kulimbikitsa zakudya zochepetsa lipid, zomwe ayenera kupitiriza kuzitsatira panthawi yonse ya chithandizo.

Mlingo woyambirira ndi pafupifupi 10 mg kamodzi patsiku. Mlingo umasiyanasiyana 10 mpaka 80 mg kamodzi patsiku. Mankhwala amatha kumwa nthawi iliyonse masana, mosasamala nthawi yakudya. Mlingo umasankhidwa poganizira magawo angapo a LDL-C, cholinga cha mankhwala ndi zotsatira zake. Kumayambiriro kwa chithandizo chamankhwala ndi / kapena pakuwonjezeka kwa mlingo wa Torvacard, ndikofunikira kuyang'anira kuchuluka kwa plasma lipid masabata onse a 2-4 ndikusintha mlingo moyenerera. Pazipita tsiku lililonse 80 mg mu 1 mlingo.

Mu chachikulu hypercholesterolemia ndi hyperlipidemia wosakanikirana, nthawi zambiri, mlingo wa 10 mg wa Torvacard kamodzi patsiku wokwanira. A achire kwambiri zimachitika pambuyo 2 milungu, monga lamulo, ndipo pazipita achire zotsatira zambiri zimawonedwa pambuyo 4 milungu. Ndi chithandizo cha nthawi yayitali, izi zimapitirira.

Zotsatira zoyipa

• mutu
• asthenia
• kusowa tulo
• chizungulire
• kugona
• zolota
• amnesia
• kukhumudwa
• zotumphukira neuropathy
• ataxia
• paresthesia
• kusanza, kusanza,
• kudzimbidwa kapena kutsegula m'mimba
• chisangalalo
• kupweteka m'mimba
• kukwiya kapena kulakalaka kudya,
• myalgia
• arthralgia,
• myopathy
• myositis
• kupweteka kumbuyo
• kukhathamira m'matumbo amiyendo,
• Khungu
• zotupa
• urticaria
• angioedema,
• anaphylactic shock,
• zotupa zambiri
• polymorphic exudative erythema, kuphatikizapo Matenda a Stevens-Johnson
• toxic epidermal necrolysis (matenda a Lyell),
• hyperglycemia
• achina,
• kupweteka pachifuwa
• zotumphukira edema,
• kusabala
• alopecia
• tinnitus
• kunenepa
• malaise
• kufooka
• thrombocytopenia
• kulephera kwachiwiri kwaimpso.

Contraindication

• odwala matenda a chiwindi kapena kuwonjezeka kwa zochitika za transaminases mu seramu yamagazi (koposa nthawi 3 poyerekeza ndi VGN) yosachokera,
• Kulephera kwa chiwindi (kuopsa kwa A ndi B pamawonekedwe a Mwana-Pugh),
• matenda obadwa nawo, monga lactose tsankho, kuchepa kwa lactase kapena malabsorption a glucose (chifukwa cha kupezeka kwa lactose mu kapangidwe kake),
• mimba
• kuyamwa
• azimayi amsinkhu wobereka omwe sagwiritsa ntchito njira zokwanira zakulera,
• ana ndi achinyamata ochepera zaka 18 (mphamvu ndi chitetezo sizinakhazikitsidwe),
• Hypersensitivity pamagawo a mankhwala.

Mimba komanso kuyamwa

Torvacard imakhudzana ndi pakati komanso kuyamwa.

Popeza cholesterol ndi zinthu zopangidwa kuchokera ku cholesterol ndizofunikira pakukula kwa mwana wosabadwayo, chiwopsezo choteteza HMG-CoA reductase chimaposa phindu logwiritsa ntchito mankhwalawa panthawi yapakati. Mukamagwiritsa ntchito lovastatin (choletsa HMG-CoA reductase) ndi dextroamphetamine mu trimester yoyamba ya kubereka, kubadwa kwa ana omwe ali ndi mafupa osakanikirana, tracheo-esophageal fistula, ndi anus atresia amadziwika. Ngati amayi apezeka ndi pakati pa mankhwala ndi Torvacard, mankhwalawa amayenera kuyimitsidwa nthawi yomweyo, ndipo odwala ayenera kuchenjezedwa za chiwopsezo chomwe chingakhalepo kwa mwana wosabadwayo.

Ngati ndi kotheka kugwiritsa ntchito mankhwalawa panthawi yoyamwitsa, chifukwa cha zovuta za makanda, nkhani yoletsa kuyamwitsa iyenera kuthetsedwa.

Kugwiritsira ntchito kwa akazi amisinkhu yakubereka ndikotheka kokha ngati njira zodalirika zakulera zikugwiritsidwa ntchito. Wodwala ayenera kudziwitsidwa za chiopsezo cha chithandizo cha mwana wosabadwayo.

Gwiritsani ntchito ana

Mankhwalawa amaletsedwa kugwiritsidwa ntchito mwa ana ndi achinyamata osakwana zaka 18 (zoyenera ndi chitetezo sizinakhazikitsidwe).

Malangizo apadera

Musanayambe mankhwala a Torvacard, ndikofunikira kuyesa kuthana ndi hypercholesterolemia mwa kudya mokwanira mankhwala, zolimbitsa thupi, kuchepa thupi kwa odwala omwe ali ndi kunenepa kwambiri komanso kuthandizira zina.

Kugwiritsa ntchito ma HMG-CoA reductase inhibitors kuti muchepetse lipids zamagazi kungapangitse kusintha kwa magawo amomwe amomwe amachititsa ntchito ya chiwindi. Kuchita kwa chiwindi kuyenera kuyang'aniridwa musanayambe mankhwala, masabata 6, masabata 12 mutayamba kumwa Torvacard pambuyo poti kuchuluka kulikonse kwa mankhwalawa, komanso nthawi ndi nthawi (mwachitsanzo, miyezi isanu ndi umodzi iliyonse). Kuwonjezeka kwa ntchito ya hepatic michere mu seramu yamagazi imatha kuwonedwa pa nthawi ya chithandizo cha Torvard (nthawi zambiri m'miyezi itatu yoyambirira). Odwala omwe ali ndi kuchuluka kwa transaminase ayenera kuwunikidwa mpaka milingo ya enzyme ibwerere ku yachilendo. Ngati malingaliro a ALT kapena AST apamwamba kwambiri kuposa katatu kwa VGN, tikulimbikitsidwa kuti muchepetse mlingo wa Torvacard kapena kusiya chithandizo.

Kuchiza ndi Torvacard kungayambitse myopathy (kupweteka kwa minofu ndi kufooka kophatikiza ndi kuwonjezeka kwa ntchito za CPK ndi nthawi zopitilira 10 poyerekeza ndi VGN). Torvacardum ikhoza kuyambitsa kuchuluka kwa serum CPK, yomwe iyenera kukumbukiridwa pakuwonetsetsa kusiyanasiyana kwa kupweteka pachifuwa. Odwala akuyenera kuchenjezedwa kuti ayenera kupita kwa dokotala ngati vuto lopanda kufooka kapena kufooka kwa minofu kumachitika, makamaka ngati akuphatikizidwa ndi malaise kapena malungo. Kuchiza kwa Torvard kuyenera kusiyidwa kwakanthawi kapena kulekeka kwathunthu ngati pali chizindikiro cha myopathy kapena choopsa chokhala ndi kulephera kwa impso chifukwa cha rhabdomyolysis (mwachitsanzo, matenda opweteka kwambiri, kusokonekera kwa hypotension, opaleshoni yayikulu, kuvulala kwambiri, kupweteka kwa metabolic, endocrine ndi electrolyte )

Kukopa pa kuyendetsa galimoto ndikugwira ntchito ndi zinthu

Zotsatira zoyipa za Torvacard pakutha kuyendetsa magalimoto ndi kuchita zinthu zina zomwe zimafunikira chidwi ndi kuthamanga kwa zochitika zama psychomotor sizinanenedwe.

Kuyanjana kwa mankhwala osokoneza bongo

Pogwiritsa ntchito munthawi yomweyo cyclosporine, fibrate, erythromycin, clarithromycin, mankhwala a immunosuppressive ndi antifungal a gulu la azole, nicotinic acid ndi nicotinamide, mankhwala omwe amalepheretsa kagayidwe kosungidwa ndi CYP450 isoenzyme 3A4, ndi / kapena kuchuluka kwa magazi ndi placort ya plas amadzuka. Popereka mankhwala awa, phindu lomwe likuyembekezeredwa komanso chiopsezo chamankhwala liyenera kuyesedwa mosamala, odwala ayenera kuwunikidwa pafupipafupi kuti adziwe kupweteka kwa minofu kapena kufooka, makamaka m'miyezi yoyambirira ya chithandizo komanso panthawi yowonjezera mlingo wa mankhwala aliwonse, nthawi ndi nthawi muzindikire ntchito ya KFK, ngakhale izi kupewa kukula kwa myopathy. Mankhwala a Torvard amayenera kusiyidwa ngati pali kuwonjezeka kwodziwika kwa zochitika za CPK kapena kukhalapo kwa myopathy yotsimikizika kapena yotsimikizika.

Torvacard analibe gawo lalikulu pakukhudzidwa kwa terfenadine mu plasma yamagazi, yomwe imapangidwa makamaka ndi 3A4 CYP450 isoenzyme, pankhaniyi, ndizokayikitsa kuti atorvastatin amatha kukhudza kwambiri magawo a pharmacokinetic a magawo ena a CYP450 3A4 isoenzyme. Ndi munthawi yomweyo kugwiritsa ntchito atorvastatin (10 mg kamodzi patsiku) ndi azithromycin (500 mg kamodzi patsiku), kuchuluka kwa atorvastatin m'madzi a m'magazi sikusintha.

Ndi kuyambitsa munthawi yomweyo kwa atorvastatin ndi kukonzekera komwe kumakhala ndi magnesium ndi aluminium hydroxides, kuchuluka kwa atorvastatin m'madzi a m'magazi kunatsika pafupifupi 35%, komabe, kuchepa kwa mulingo wa LDL-C sikunasinthe.

Ndi munthawi yomweyo kugwiritsa ntchito colestipol, plasma wozungulira atorvastatin utachepa pafupifupi 25%. Komabe, lipid-kutsitsa mphamvu ya kuphatikiza kwa atorvastatin ndi colestipol imaposa ya aliyense mankhwala payekhapayekha.

Kugwiritsa ntchito pamodzi kwa Torvacard sikukhudza ma pharmacokinetics a phenazone, chifukwa chake, kuyanjana ndi mankhwala ena omwe amapangidwa ndi CYP450 isoenzymes yomwe siyikuyembekezeredwa.

Mukamaphunzira kuyanjana kwa atorvastatin ndi warfarin, cimetidine, phenazone, palibe zizindikiritso zofunika kwambiri zamankhwala zomwe zapezeka.

Kugwiritsa ntchito munthawi yomweyo mankhwala omwe amachepetsa kuchuluka kwa mahomoni amkati (kuphatikizapo cimetidine, ketoconazole, spironolactone) kumawonjezera chiopsezo chochepetsa mahomoni amtundu wa antioxidosis (kusamala kuyenera kuchitidwa).

Palibe zochitika zamatenda zofunikira za atorvastatin zomwe zimagwiritsidwa ntchito ndi antihypertensive mankhwala, komanso estrogens.

Ndi kugwiritsa ntchito pamodzi kwa Torvacard pa mlingo wa 80 mg patsiku ndi njira zakulera zamkati zomwe zimakhala ndi norethindrone ndi ethinyl estradiol, kuchuluka kwakukulu kwa kuchuluka kwa norethindrone ndi ethinyl estradiol kumawonedwa ndi pafupifupi 30% ndi 20%, motero. Izi ziyenera kuganiziridwa posankha njira yolerera pakamwa ya azimayi omwe amalandila Torvacard.

Ndi munthawi yomweyo kugwiritsa ntchito atorvastatin pa mlingo wa 80 mg ndi amlodipine pa 10 mg, ma pharmacokinetics a atorvastatin m'chigawo chofanana sanasinthe.

Mobwerezabwereza makonzedwe a digoxin ndi atorvastatin pa 10 mg, kuchuluka kwa ndende ya digoxin m'madzi a m'magazi sikunasinthe. Komabe, pamene digoxin imagwiritsidwa ntchito limodzi ndi atorvastatin pa mlingo wa 80 mg patsiku, kuchuluka kwa digoxin kumawonjezeka pafupifupi 20%. Odwala omwe amalandira digoxin osakanikirana ndi atorvastatin amafunikira kuyang'aniridwa.

Kafukufuku wokhudzana ndi mankhwala ena sanachitike.

Mndandanda wa mankhwala Torvacard

Zofanana muzochitika zamagulu:

• Anvistat
• Atocord
• Atomax
• Atorvastatin
• Atorvox
• Atoris
• Vazator
• Lipona
• Lipoford
• Liprimar
• Liptonorm,
• Torvazin
• Tulip.

Ma Analogs mu pharmacological group (ma statins):

• Akorta,
• Machitidwe
• Anvistat
• Apextatin,
• Atherostat
• Atocord
• Atomax
• Atorvastatin
• Atorvox
• Atoris
• Vazator
• Vasilip
• Zokor
• Zokor Forte
• Zorstat
• Cardiostatin
• Crestor
• Leskol,
• Leskol forte
• Lipobay,
• Lipona
• Lipostat
• Lipoford
• Liprimar
• Liptonorm,
• Lovacor
• Lovastatin
• Lovasterol
• Mevacor
• Medostatin,
• Mertenil
• Aries
• Pravastatin,
• Rovacor
• Rosuvastatin,
• Rosucard,
• Rosulip,
• Roxer
• SimvaHexal,
• Simvakard,
• Simvacol
• Simvalimite
• Simvastatin
• Simvastol
• Simvor
• Simgal
• Simlo
• Chinyengo
• Tevastor
• Torvazin
• Tulip
• Holvasim
• Holetar.

Zizindikiro zogwiritsidwa ntchito

Torvacard 10 mg

Mapiritsi amatchulidwa monga gawo la chithandizo chokwanira.Kodi Torvacard amagwiritsidwa ntchito bwanji? Mankhwala amathandizidwa odwala omwe ali ndi zotsatirazi pathologies:

• Pankhani ya hypercholesterolemia yoyamba, hyperlipidemia (cholowa, chosakhala choloŵa komanso chophatikiza), chakudya chimayikidwa panthawi ya chithandizo chomwe chimachepetsa cholesterol yathunthu ndi triglycerides (ngati, malinga ndi zotsatira za kusanthula, izi zikuwonjezera),
• Ndi kuwonjezeka kwa seramu ndende ya triglycerides (mtundu 4 hypertriglyceremia malinga ndi Frederickson), mkhutu wa mafuta m'thupi ndi lipoprotein metabolism (abetalipoproteinemia ndi hypobetalipoproteinemia - dsetalipoproteinemia -
• Ndi okwana mafuta m'thupi komanso kuchuluka kwa lipoprotein otsika kwambiri osakanikirana ndi homozygous Famer hypercholesterolemia,
• Kuwonongeka kwa mtima dongosolo (ischemia, matenda ashuga, matenda oopsa, kuthana ndi vuto la matenda am'mimba, matenda ashuga, matenda ammimba,
• Kupewera kwachiwiri kwa mavuto atatha kupanikizika kwa myocardial, stroko, angina pectoris.

Komanso, mapiritsi amayikidwa kwa odwala omwe ali pachiwopsezo chotukuka kwa matenda a mtima (kusuta, matenda a shuga, ukalamba).

Malangizo ogwiritsira ntchito Torvacard ndi mlingo

Pa mankhwala, wodwalayo ayenera kutsatira zakudya zopatsa mphamvu (kuletsa mchere, mchere, zakudya zamafuta, kugwiritsa ntchito chimanga, masamba, madzi).

Malinga ndi malangizo ogwiritsira ntchito Torvacard, mapiritsi amatengedwa kwathunthu (mkati), osasamala chakudya ndi nthawi ya tsiku. Kuchiza kumachitika malinga ndi chiwembu. Mlingo woyambirira ndi 10 mg (kamodzi patsiku). Kenako kuchuluka kwa mankhwalawa kumawonjezeka ndipo, kutengera zovuta za kupezeka kwake, mlingo wa tsiku ndi tsiku umachokera pa khumi mpaka makumi asanu ndi atatu mg.

Mankhwalawa, magawo a lipid m'magazi amayang'aniridwa labotale milungu iwiri iliyonse. Izi zimathandizira kusintha kwa mlingo wake.

Zomwe zimagwiritsidwa ntchito pa Torvacard:

- Ndi cholowa cholimbikitsa hypercholesterolemia homozygous, zolimbikitsidwa tsiku lililonse ndi 80 mg,
- Mlingo sasinthidwa vuto la chiwindi ndi impso.
- Zomwe zimalembedwa pakuwongolera zochita za ana ndizochepa, chifukwa chake, ana amayenera kupita kuchipatala panthawi yamankhwala (kupewa zotsatira zosagwirizana ndi mankhwalawa),
- Odwala okalamba amapirira bwino mapiritsi, kotero kusintha kwa mankhwalawa sikofunikira.

Odwala omwe amagwiritsa ntchito anticoagulant kapena coumarin kukonzekera, asanaikidwe kwa Torvacard, akulimbikitsidwa kuti awunikenso za PV (prothrombin time). Chisamaliro chikuyenera kuthandizidwa ndikaphatikizidwa ndi HMG-CoA reductase inhibitors ndi ma fiber.

Contraindication ndi bongo

Mapiritsi ali ndi ma contraindication ambiri, motero, amadziwika ndi dokotala atafufuza mwatsatanetsatane wodwala. Sitikulimbikitsidwa kuchitira Torvacard ndi pathologies:

• Hypersensitivity to main yogwira chinthu kapena zowonjezera (magnesium oxide, microcrystalline cellulose, lactose monohydrate, magnesium stearate),
• Matenda a chiwindi
• Kuchuluka kwa michere ya chiwindi ya etiology yosadziwika,
• Ana ochepera zaka 18 (chitetezo, kugwira ntchito bwino ndi kulekerera kwa mankhwala sanakhazikitsidwe), kupatula chithandizo cha heterozygous Famel hypercholesterolemia,
• Yofanana makonzedwe a proteinase zoletsa (mankhwalawa HIV).

Mankhwalawa sanatchulidwe kwa azimayi pokonzekera. Popeza atorvastatin imadutsa mkaka wa m'mawere, silinafotokozeredwe nthawi ya mkaka wa m'mawere.

• Kuchokera pakati mantha dongosolo - kugona tulo, migraine, chizungulire, kusokonekera mphamvu, kufooka minofu,
• Kuchokera mmimba thirakiti - nseru, kusanza, kusokonezeka kwa magazi, kutulutsa, kupweteka kwa epigastric, kutupa kwa chiwindi ndi kapamba,
• pa gawo la masculoskeletal system - kupweteka kwa minofu ndi kuphatikizika, kupindika kwa minofu minofu (mpaka kuwonongeka kwa minyewa yam'mimba), kutupa kwa minofu.

N`zothekanso kukula kwa thupi lawo siligwirizana - redness khungu, mawonekedwe a kakang'ono zotupa, kuyabwa, osowa - urticaria.
Mankhwala osokoneza bongo amachitika chifukwa cha kupitiliza kwa chithandizo chamankhwala kapena motsutsana ndi gawo limodzi la mlingo waukulu. Pankhaniyi, wodwala amagonekedwa m'chipatala, chithandizo cha mankhwala chimayikidwa. Hemodialysis siyothandiza.

Analogi za Torvakard, mndandanda

Torvacard, monga mankhwala ena omwe ali ndi atorvastatin, amamugulitsa m'mafakisoni popanda mankhwala. Koma izi sizitanthauza konse kuti wodwalayo amatha kusankha payekha mankhwala ena, omwe angakhale otsika mtengo kapena ovomerezeka ndi katswiri wazamankhwala.

Ngati mapiritsi a Torvard sanali oyenera kwa wodwala, ndiye kuti adokotala atha kukufotokozera:

Chofunikira - malangizo ogwiritsira ntchito Torvacard, mtengo ndi kuwunika sizigwira ntchito pa analogues ndipo sangagwiritsidwe ntchito ngati chiwongolero chogwiritsira ntchito mankhwala omwe ali ndi kapangidwe kake kapena machitidwe ena. Nthawi zonse zochizira ziyenera kupangidwa ndi dokotala. Mukasinthira Torvacard ndi analogue, ndikofunikira kuti mupeze upangiri waluso, mungafunike kusintha njira zamankhwala, mankhwalawa, etc. Osadziletsa!

Mankhwala onse amaikidwa kuti achepetse cholesterol yotsika, otsika osalimba a lipoprotein ndi triglycerides mu pulayimale kapena achibale hypercholesterolemia. Ma analogi a Torvacard amakhalanso ndi ma contraindication ambiri, kotero wodwalayo amawunikira magawo a lipid asanachitike, panthawi ndi pambuyo poti athandizidwe. Malingaliro a madokotala okhudzana ndi mankhwalawa ndiabwino: mankhwalawa, monga lamulo, amalekeredwa bwino - zovuta zimayamba kuchepa kwambiri, ndipo mlingo wake ndi wosavuta kudziwa.

Zotsatira za pharmacological

Zokomera gulu ma statins ndikupereka lipid-kutsitsa kwenikweni. Tikuletsa mosamala komanso mwaphikisano ma enzyme omwe akukhudzidwa ndi kaphatikizidwe cholesterol.

Triglycerides ndipo cholesterol imakhala madera a atherogenic lipoprotein mu chiwindi, pambuyo pake magazi amawonjezeredwa kwa zotumphukira. Mwa kucheza ndi ma receptors lipoproteinskachulukidwe kakang'ono amasintha kukhala ma lipoprotein.

Mwa kuletsa HMG-CoA reductase, lipoproteins amachepetsa ndipo cholesterol m'magazi. Inachepetsa kaphatikizidwe ka LDL ndikuwonjezera zochitika za zolandilira.

Mankhwala amatha kuchepetsa kuchuluka kwa LDL ndi homozygous hypercholesterolemia cholowa, pomwe mankhwala ena alibe.

Mankhwala amachepetsa cholesterol ndi 30-46%, lipoproteins atherogenic ndi 41-61%, triglycerides ndi 14-33% ndikuwonjezera zomwe zili lipoproteins ndi antiatherogenic katundu.

Pharmacodynamics ndi pharmacokinetics

M'magazi, kuchuluka kwambiri kwa mankhwalawa kumachitika mkati mwa mphindi 60-120. Kudya kumachepetsa, koma kumachepetsa cholesterol kufananizidwa ndi chimenecho chopanda chakudya. Ngati mukumwa ntchito madzulo, kuchuluka kwa mankhwalawa kumakhala kotsika kuposa komwe kumachitika m'mawa.

Amakhala m'mapuloteni a magazi ndi 98%. Zimapukusidwa mu chiwindi ndikupanga metabolites yogwira.

Amachotseredwa ndi bile, theka la moyo ndi maola 14. Kugwiritsa ntchito bwino kwa mankhwalawa kumasungidwa chifukwa cha metabolites yogwira mpaka maola 30. Ndi hemodialysis, samachotsa.

Zisonyezo Torvakard

Mapiritsi a Torvacard - amachokera kuti?

Mankhwalawa amagwiritsidwa ntchito limodzi ndi zakudya:

• kuchepetsa magazi cholesterolatherogenic lipoproteins, triglycerides, apolipoprotein B komanso kuchuluka kwa HDL mu hypercholesterolemia, heterozygous komanso kuphatikiza hypercholesterolemia (Fredrickson mitundu IIa ndi IIb),
• chithandizo cha odwala omwe izi zimawonjezeka triglycerides m'magazi (lembani IV malinga ndi Fredrickson) ndipo lembani III malinga ndi Fredrickson (dysbetalipoproteinemia), ngati zakudya sizikubweretsa,
• kuchepetsa cholesterol ndi LDL ndi homozygous mtundu wa banja hypercholesterolemia,
• mankhwalawa mtima ndi mtima matenda pamaso pa okwera zifukwa za matenda a mtima matenda (ochepa matenda oopsaodwala opitilira zaka 55 sitiroko mu anamnesis, albinuriaHypertrophy ya kumanzere kwamitsempha, kusuta, zotumphukira matenda,Matenda a mtima wa Ischemic m’banja matenda ashuga).

Chizindikiro chodziwika bwino ku Torvacard ndi chenjezo lachiwiri myocardial infarationimfa kusinthansositiroko kumbuyo dyslipidemia.

Contraindication

• kuvulala kwambiri kwa chiwindi,
• malo okwera transaminase m'magazi
• chibadidwe chokhala ndi glucose ndi lactose, kuperewera kwa lactase,
• azimayi amsinkhu wobereka osagwiritsa ntchito kulera,
• mimba ndi yoyamwitsa,
• ana ochepera zaka 18
• kusalolera payekha.

Kugwiritsira ntchito bwino zovuta zama metabolic ndi metabolic, ochepa matenda oopsa, uchidakwaanasamutsa matenda a chiwindi sepsis, kusintha kwamphamvu yamagetsi yamagetsi, ndi matenda ashuga, khunyu, kuvulala ndi maopaleshoni akuluakulu.

Zotsatira zoyipa

Msempha: masoka opweteka, dyspepsiamseru ndi kusanza, kusokonekera kwa tulo, kusintha kwa kulakalaka. kapamba ndi chiwindi, jaundice.

Matenda a minofu ndi mafupa: kupweteka mafupa ndi minofu, kumbuyo, kukokana m'matumbo a miyendo, myositis.

Zowopsa zasayansi: kusintha kwa magawo shugakuchuluka kwa zochitika michere ya chiwindi ndi creatine phosphokinase m'magazi.

Mawonetsedwe ena atha kuphatikizira zotumphukira zotupa za edema, kupweteka pachifuwa, tinnitus, dazi, kufooka, kuchuluka kwa thupi, kusabala, kulephera kwaimpso kwa chikhalidwe chachiwiri, kuchepa kwa chiwerengero cha mapulateleti.

Mapiritsi a cholesterol nthawi zina zinayambitsa kukhumudwa, kuphwanya kugonana, zochitika zowonongeka zazowonongeka zam'mapapo, matenda ashuga (chitukuko chimatengera zinthu zomwe zingaike pachiwopsezo - glucose kudya, ochepa matenda oopsa, cholozera cha thupi, hypertriglyceridemia).

Malangizo ogwiritsira ntchito Torvacard (Njira ndi Mlingo)

Pa chithandizo, wodwala ayenera kutsatira zakudya zokhala ndi lipid.

Chithandizo cha mankhwalawa chimayamba ndi 10 mg patsiku, kenako amachulukitsidwa mpaka 20 mg. Mlingo wothandizira tsiku ndi tsiku umachokera ku 10 mpaka 80 mg. Mlingo umasankhidwa poganizira magawo a labotale ndi mawonekedwe ake.

Mankhwalawa amatengedwa mosasamala chakudya.

Asanatenge ndi, ngati kuli kotheka, kusintha mlingo, kuyang'anira labulotip ya milingo ya lipid kumachitika.

Zotsatira za ntchito zimachitika patatha masiku 14.

Zochizira odwala homozygous hypercholesterolemia Chimodzi mwazinthu zochepa zomwe zimapereka chithandizo ndi Torvacard, malangizo omwe angagwiritsidwe ntchito amadziwitsa bwino mlingo wa tsiku ndi tsiku, womwe ndi 80 mg.

Kuchita

Kugwiritsa ntchito mankhwala omwe amalepheretsa kagayidwe koyendetsedwa ndi enzyme ya CYP450, erythromycinmankhwala antifungal ndi immunosuppressive, fibrate, cyclosporine, chindwana, nicotinamide, nicotinic acid kuchuluka kwa Torvacard m'magazi kumawonjezeka. Nthawi yomweyo, mwayi wa myopathy ukuwonjezeka, motero ndikofunikira kuwongolera mulingo wa CPK m'magazi.

Kulandila kwa ndalama ndi aluminium hydroxide kapena magnesium amachepetsa kukhudzidwa kwa Torvacard, koma izi sizikhudza kugwiraku.

Kuphatikiza ndi colestipol amachepetsa ndende atorvastatinkoma olowa nawo lipid-kutsitsa kwenikweni limaposa aliyense payekhapayekha.

Phwando kulera kwamlomo ndipo tsiku lililonse mlingo wa Torvacard 80 mg umawonjezera zomwe zili ethinyl estradiol m'magazi.

Gwiritsani ntchito limodzi digoxin amachepetsa kugwiritsidwa ntchito kwa 20%.

Malangizo apadera

Asanalandire chithandizo, muyenera kuyesa kuchepetsa cholesterol ndi zakudya, mankhwala kunenepa ndi matenda ophatikizira, kuchuluka kwa zolimbitsa thupi.

Pa chithandizo, ndikofunikira kuwongolera msinkhu wa AST ndi ALT. Kwa nthawi yoyamba, ulamuliro umachitika isanachitike, pambuyo pa masabata 6 ndi miyezi itatu itatha chithandizo, komanso mutasintha mawonekedwe komanso kamodzi pa miyezi isanu ndi umodzi. Ngati kuchuluka kwa ma enzymes kukwera nthawi zopitilira 3, mankhwalawo amathetsedwa.

Kudya kwa Torvacard kungayambitse kufooka kwa minofu ndi zowawa (myopathies) ndi kuchuluka kwa CPK m'magazi. Ngati mukumva kupweteka kwa minofu kapena kufooka kuphatikiza ndi malungo, muyenera kufunsa dokotala.

Mankhwalawo amathetsedwa pachiwopsezo cha kulephera kwa impso chifukwa rhabdomyolysis. Zimatha kukhala zowawa, zambiri zogwira ntchito, kuperewera kwa magazi ndi zamagetsi, ochepa hypotensionmatenda oopsakukokana.

Kudya kwa Torvacard kumatha kubweretsa chitukuko matenda ashuga mwa odwala omwe ali pachiwopsezo chowonjezeka. Koma ndikofunikira kukumbukira kuti maubwino otenga ma statins ndi apamwamba kuposa chiopsezo cha matenda ashuga, chifukwa chake palibe chifukwa chothetsera mankhwalawo, ndipo odwala omwe ali pachiwopsezo ayenera kukhala moyang'aniridwa ndi dokotala.

Ndemanga pa Torvakard

Ndemanga za Torvacard zomwe zimapezeka pamaforamu amatilola kunena kuti mankhwalawa ndi othandizadi. Amasankhidwa kwambiri ndi akatswiri a mtima kuti akhale otsika. cholesterol komanso kuteteza odwala ku sitiroko ndi vuto la mtima. Pambuyo pakugwiritsa ntchito miyezi 1-2, kuchepa kwakukulu kwa milingo ya cholesterol kumawonedwa. Amayi ambiri amawoneka osangalatsa - kuwonda.

Mwa zoperewera zimatha kutchedwa kuti mankhwala a cholesterol angayambitse kusowa tulo ndi kuyabwa zotupa thupi.

Kuphatikizika, mawonekedwe a mankhwala ndi mtengo

Mapiritsi a convex, ophimbidwa ndi filimu, amakhala ndi mchere wa calcium wa atorvastatin wokwanira 10, 20 kapena 40 g. Onjezani zinthu zoyambira:

1. Microcrystalline ndi hydroxypropyl cellulose,
2. Magnesium okusayidi ndi owala,
3. Croscarmellose sodium
4. Lactose mfulu
5. Hypromellose,
6. Silika
7. Titanium dioxide
8. Macrogol 6000,
9. talcum ufa.

Mankhwala omwe mumalandira. Kwa Torvacard, mtengo wamtengo muma pharmacyl amatengera muyeso wawo komanso kuchuluka kwa bokosilo, mwachitsanzo, Torvacard 20 mg, mtengo wake ndi mapiritsi 90. -1066 rub.

• 10 mg, 30 ma PC. - 279 ma ruble,
• 10 mg, ma PC 90. - 730 ruble,
• 20 mg, 30 ma PC. - 426 rub,
• 40 mg, 30 ma PC. - 584 ma ruble,
• 40 mg, ma PC 90. -1430 rub.

Mankhwalawa ndi oyenera kugwiritsidwa ntchito kwa zaka 4, palibe mikhalidwe yapadera pakusungika kwake komwe kumafunikira.

Mankhwala

Mankhwala opangidwa Torvacard amalepheretsa kuchepa kwa HMG-CoA, kuchepetsa kuchepa kwa cholesterol. Cholesterol, triglycerides, lipoproteins ali mkati mwa njira yoyenda mozungulira.

Mitundu yambiri ya cholesterol yathunthu (OH), LDL ndi apolipoprotein B imakhala pachiwopsezo cha atherosulinosis ndi zovuta zake, mulingo wokwanira wa HDL umachepa, m'malo mwake, izi zikuwonetsa.

Poyeserera nyama, zidapezeka kuti statin imachepetsa kuchuluka kwa cholesterol ndi LP, poletsa HMG-CoA reductase ndikupanga cholesterol. Kuchuluka kwa cholesterol receptors “yoyipa” kukuchulukanso, zomwe zikuwonjezera mayamwidwe amtunduwu wa lipoprotein. Amachepetsa atorvastine ndi LDL kaphatikizidwe.

Torvacard amathandizira kuchepetsa kuchuluka kwa mahotela ku OS, VLDL, TG, LDL, ngakhale kwa odwala omwe siabanja la mtundu hypercholesterolemia ndi dyslipidemia, samakonda kuyankha mankhwala ena.

Pali umboni wa mgwirizano womwe ulipo pakati pa anthu omwe amafa pamitsempha ya mtima ndi mitsempha ya magazi komanso zomwe zili mu LDL ndi OH komanso molingana ndi HDL.

Torvacard ndi ma metabolites ake amagwira ntchito mthupi la munthu. Malo akuluakulu a chitukuko ndi chiwindi, chomwe chimagwira ntchito yopanga cholesterol ndi chilolezo cha LDL. Poyerekeza ndi momwe mankhwalawo amapezekera, mulingo wa Torvacard umathandizika mwachangu ndi kuchepa kwa milingo ya LDL.

Mlingo waumwini umasankhidwa molingana ndi zotsatira za njira yochizira.

Pharmacokinetics

1. Zogulitsa. Mankhwalawa amalowerera m'matumbo pambuyo pakugwiritsidwa ntchito kwamkati, mpaka kufika pakulimbikitsidwa kwambiri patatha ola limodzi kapena awiri. Mlingo wa mayamwidwe ukuwonjezeka ndi kuchuluka kwa Torvacard. Bioavailability yake ali 14%, mulingo wa inhibitory zochita motsutsana ndi HMG-CoA reductase ndi 30%. Chizindikiro cha otsika bioavailability akufotokozera ndi pre-zokhudza zonse zokhudza m`mimba thirakiti ndi biotransformation mu chiwindi. Chakudya chimabwezeretsa kuchuluka kwa kuyamwa kwa mankhwalawa, koma zakudya zophatikizika kapena zophatikizika sizikhudzanso kutsika kwa cholesterol yoyipa. Ngati mumagwiritsa ntchito statin madzulo, kuyika kwake kumachepetsedwa ndi 30%, koma kulephera kumeneku sikukhudzana ndikuchepetsa kwa cholesterol "yoyipa".
2. Kugawa. Zoposa 98% za zinthu zomwe zimagwira amapanga mapuloteni amwazi. Kuyesa pa makoswe kunawonetsa kuti mankhwalawa amatha kudutsa mkaka wamawere.
3. Kupenda. Mankhwala amakhathamiritsa kwambiri. Pafupifupi 70% ya zochita zake zotsutsana ndi HMG-CoA reductase zimaperekedwa ndi metabolites.
4. Kuswana. Ambiri a atorvastine ndi omwe amachokera amachotsedwa ndi bile pambuyo pokonza m'chiwindi. Kuchulukitsa kwa statin theka moyo mpaka maola 14. Mutamwa, osapitirira 2% ya mankhwala omwe amalowa mkodzo.
5. Zogonana ndi zaka. Mwa anthu athanzi la zaka zokhwima, kuchuluka kwa zinthu za statin ndizokwera kuposa mwa achinyamata, chifukwa chake, kuchuluka kwa kuchepetsa kwa LDL kumakulirapo. Mwa azimayi, zomwe zili mu Torvacard m'magazi ndizambiri, koma izi sizikhudza kuchepa kwa LDL. Palibe umboni wa momwe ana amathandizira ku Torvacard.
6. Zotsatira zam'mimba. Kulephera kwamkati sikukhudza kuchuluka kwa protein ndipo sikutanthauza kusintha kwa mlingo. Kutsimikizika kwa mankhwalawa sikungathandize hemodialysis, popeza atorvastine imamangidwa kumapulogalamu.
7. Matenda a hepatatic. Matenda a chiwindi omwe amaphatikizidwa ndi kumwa mowa mwauchidakwa amakhudzanso kuchuluka kwa mankhwalawa m'magazi: zomwe zimakwezedwa kwambiri.

Kugwirizana kwa Torvacard ndi mankhwala ena

Zomwe zidawonetsedwa ngati zosintha maulendo angapo ndikuwerengeka kwa milandu yogwiritsidwa ntchito kamodzi ndi mankhwala ndi Torvacard okha.

Zomwe zawonetsedwa pazowerengera peresenti ndikusiyana kwa deta yokhudza kugwiritsidwa ntchito kwa Torvacard padera. AUC - dera lomwe lili pansi pa mpendero woonetsa nthawi ya atorvastatin kwakanthawi. C max - zomwe zimakhala kwambiri m'magazi.

Mankhwala othandizira kufanana ndi kumwa

MlingoKusintha kwa AUCSinthani C _max Cyclosporin 520 mg / 2r. / tsiku, mosalekeza.10 mg 1 p./day kwa masiku 288,7 p.10.7 r Saquinavir 400 mg 2 p./day / Ritonavir 400 mg 2 p./day, masiku 1540 mg 1 p./day kwa masiku 43,9 p.4,3 p. Telaprevir 750 mg pambuyo maola 8, masiku 10.20 mg RD7.88 p.10,6 p. Itraconazole 200 mg 1 p. / tsiku, masiku 4.40 mg RD.3,3 tsa.20% Clarithromycin 500g 2 r./day, masiku 9.80 mg 1 p./day Kwa masiku 84,4 r5.4 tsa. Fosamprenavir 1400 mg 2 p./day, masiku 14.10 mg kamodzi pa tsiku kwa masiku anayi.2.3 tsa.. 4.04 tsa. Madzi a mphesa, 250 ml 1 r. / Tsiku.40 mg 1 p./day n37%16% Nelfinavir 1250 mg 2 p./day, masiku 1410 mg 1 p./day pa 28 d74%2.2 tsa. Erythromycin 0.5g 4 r./day, masiku 7.40 mg 1 p./day51%Palibe kusintha Diltiazem 240 mg 1 p./day, masiku 28.80 mg 1 p./day15%12% Amlodipine 10 mg, muyezo umodzi10 mg 1 p./day33%38% Colestipol 10 mg 2 p. / Tsiku, masabata 28.40 mg 1 p./day kwa milungu 28osadziwika26% Cimetidine 300 mg 1 r./day, masabata 4.10 mg 1 p./day kwa masabata awirimpaka 1%11% Efavirenz 600 mg 1 r./day, masiku 14.10 mg kwa masiku atatu.41%1% Maalox TC ® 30 ml 1 r./day, masiku 17.10 mg 1 p./day kwa masiku 1533%34% Rifampin 600 mg 1 p./day, masiku 5.40 mg 1 p./day80%40% Fenofibrate 160 mg 1 p./day, masiku 7.40 mg 1 p./day3%2% Gemfibrozil 0,6 g 2R./day., Masiku 7.40 mg 1 p./day35%mpaka 1% Boceprevir 0,8g 3 r./day, masiku 7.40 mg 1 p./day2.30 p.2.66 p.

Chiwopsezo cha matenda am'matumbo am'mimba (rhabdomyolysis) chilipo pamene Torvacard akumana ndi mankhwala omwe amalimbikitsa mulingo wake. Ndiowopsa kuphatikiza ndi cyclosporine, styripentol, telithromycin, clarithromycin, delavirdine, ketoconazole, voriconazole, posaconazole, itraconazole ndi zoletsa HIV.

Nthawi zambiri, ma analogu omwe samalumikizana ndi Torvacard amasankhidwa. Ngati sichoncho? Pakakhala chisankho chawaphatikiza, amawerengera zonse zowopsa ndi mapindu ake.

Statin ndi fusidic acid sizigwirizana: atorvastatin inathetsedwa chifukwa cha acid acid.

Ngati wodwala agwiritsa ntchito mankhwala omwe amachulukitsa kuchuluka kwa magazi mu magazi, mulingo wocheperako wa Torvacard ndi womwe. Kuwunikira pafupipafupi kwa odwala kotere kumafunikira.

Kafukufuku wina akuti ma statins amatha kuchuluka kwambiri m'magazi. Odwala omwe ali ndi prediabetes angafunike mankhwala othandizira. Koma ngati mungayerekeze izi ndikuwopseza kuwonongeka kwa mtima, ndiye kuti kugwiritsa ntchito ma statins kungakhale koyenera.

Oimira gulu lachiwopsezo (shuga wanjala mpaka 6.9 mmol / l, BMI> 30 kg / m2, kuchuluka kwa triglycerol, matenda oopsa) amayang'anitsitsa magawo a biochemical ndi chikhalidwe chachipatala.

Zinthu zina zothandizira zimatha kubweretsanso mavuto osafunikira. Mwachitsanzo, lactose siyabwino kwa galactose tsankho kapena chifukwa cha kuperewera kwa lactase.

Odwala omwe ali ndi matenda a mtima komanso odwala omwe ali pachiwopsezo cha angina pectoris Torvacard zotchulidwa pamodzi ndi zakudya.

Torvacard: Zizindikiro ndi ma contraindication kuti mugwiritse ntchito

Akuluakulu osakhala ndi chizindikiro cha matenda amtima, koma poyambira mapangidwe ake:

Mtundu wachiwiri wa anthu odwala matenda ashuga popanda zizindikiro za matenda amtima.

Ndi matenda oopsa a mtima, atorvastatin amalembedwa kuti apewe matenda oopsa a mtima komanso osapweteka, kuwongolera machitidwe a kusinthanso, komanso kuchepetsa ngozi yakugonekedwa ku zochitika za mtima.

Ndi hyperlipidemia, mankhwala a Tovakard amawonetsedwa limodzi ndi zakudya zomwe zimachepetsa ma cholesterol "oyipa" ndi triglycerol ndikuwongolera HDL.

Osati mankhwala Torvacard matenda a chiwindi mu gawo yogwira ndi kuchuluka chidwi cha zosakaniza atorvastatin.

Thorvacard pa mimba

Amayi oyembekezera, komanso azimayi omwe amatha kukhala ndi pakati, osagwiritsa ntchito Torvacard, popeza ma statins ndi owopsa kwa mwana wosabadwayo. Odwala a msinkhu wobala ana ayenera kukhala ndi udindo posankha njira zakulera.

Ngakhale kukhala ndi pakati kwabwinobwino, kuchuluka kwa cholesterol ndi triglycerol ndiokwera kuposa kwazololeka. Mankhwala a Hypolipidemic pamenepa siothandiza, chifukwa cholesterol ndi zotumphukira zake ndizofunikira kuti mwana akhazikike.

Atherosclerosis ndi matenda osachiritsika ndipo kwakhala kukuchitika kwazaka zambiri, chifukwa chake, kupweteka kwakanthawi kochepa sikungakhudze njira ya hypercholesterolemia.

Kwa Torvakard, kafukufuku wazokhudza momwe mankhwalawo amachitikira mwana wakhanda woyamwitsidwa sanachitike. Koma pazonse, ma statins amatha kulowa mkaka wa m'mawere, zomwe zimayambitsa zotsatira zosayenerera mu makanda. Chifukwa chake, ndikofunikira kuti azimayi omwe amatenga Torvacard asamutse mwana kupita ku zakudya zopanda ntchito.

Mlingo ndi makonzedwe

Ndi hyperlipidemia ndi dyslipidemia, mlingo woyamba wa mankhwala a Tovakard malangizo akutsimikizira mkati mwa 10-20 mg / tsiku. Ngati cholesterol "yoyipa" iyenera kuchepetsedwa ndi 45% kapena kupitilira, mutha kuyamba ndi 49 mg / tsiku. Mulingo wotalikirapo wa kuchuluka kwake ndi 10-80 mg / tsiku.

Ana a zaka 10 mpaka 17 ndi heterozygous hypercholesterolemia amayamba maphunzirowa ndi 10 mg / tsiku. Muyezo wapamwamba wa Tovacar ndi 20 mg / tsiku. Palibe deta pazomwe ana angachite Mlingo waukulu kwambiri. Konzani mlingo uliwonse pakatha milungu 4 kapena kupitilira.

Ngati pali mbiri ya homozygous hypercholesterolemia, mulingo wa Torvacard ndi 10-80 mg / tsiku. Statin imagwiritsidwa ntchito limodzi ndi mankhwala ochepetsa lipid, komanso ngati chithandizo chotere sichikupezeka.

Mlingo wofotokozedwa sofunikira kwa odwala omwe ali ndi vuto la impso, chifukwa ma pathologies amenewa samakhudza mphamvu ya atorvastatin.

Malangizowa salimbikitsa kupatsa Torvacard odwala omwe amagwiritsa ntchito HIV ndi hepatitis C proteinase inhibitors, komanso cyclosporine.

Kuthandiza ndi bongo

Palibe chithandizo chapadera chogwiritsa ntchito kwambiri Torvacard. Njira zimasankhidwa kutengera ndi zizindikiro zake, zothandizidwa ndi njira zothandizira. Chifukwa chogwira mwachangu zigawo zama protein, magazi sayenera kuyembekeza kuwonjezeka kwa hemodialysis.

Kwa Thoracard, malangizo atsatanetsatane ogwiritsira ntchito amapezeka pano.

Zotsatira zoyipa

Zotsatira zoyipa zamankhwala zodziwika mu 2% ya odwala omwe atenga Mlingo osiyanasiyana wa Torvacard, ngakhale atayambitsa, amapezeka patebulopo.

Atorvastatin siyimakhudza kwambiri kuchuluka kwa chidwi ndi momwe amagwirira ntchito pogwiritsa ntchito makina kapena zoyendetsa.

Torvacard - analogues

Mankhwala okhala ndi katundu wofanana atha kuphatikizira atorvastatin kapena amangokhala ndi ntchito zofananira mthupi. Musanaganize zokhala njira ina yothandizira, muyenera kufunsa dokotala nthawi zonse.

Pazigawo zogwira ntchito, mutha kusankha mtundu wa Torvakard analogues wotsika mtengo komanso wotsika mtengo:

• Atomax
• Anvistata
• Atoris
• Liptonorm,
• Lipona
• Liprimara,
• Lipoford
• Tulipa.

Malinga ndi zotsatira za zomwe zimachitika mthupi, Torvacard ikhoza kusinthidwa:

• Avestatin,
• Acortoy
• Apextatin,
• Aterostat,
• Vasilip,
• Zovatin,
• Zorstat
• Zokor,
• Cardiostatin
• Mwa mtanda
• Leskol,
• Lovastatin
• Mertenil,
• Rosuvastatin,
• Roxeroi
• SimvaHexalom,
• Simlo
• Simgal
• Simvakardom.

Musanatenge Torvacard kapena statin ina, ndikofunikira kuphunzira malangizo kuti mugwiritse ntchito, kuthana ndi zovuta komanso kugwirizanitsa ndi mankhwala othandizira.