Metformin Sandoz > Mankhwala

Mapiritsi okhala ndi mafilimu.

Zoyambira zathupi komanso mankhwala:

500 mg mapiritsi ozungulira, oyera, mapiritsi a biconvex, ophatikizidwa ndi filimu, wokhala ndi "M 500" mbali imodzi ndi yosalala mbali inayo

Mapiritsi a 850 mg mapiritsi oyera ozungulira, ophatikizidwa ndi filimu, wokhala ndi "M 850" mbali imodzi ndi notch mbali inayo.

Mankhwala

Metformin ndi biguanide yokhala ndi antihyperglycemic effect. Amachepetsa onse shuga komanso kuchuluka kwa glucose atatha kudya m'madzi am'magazi. Simalimbikitsa kubisalira kwa insulin ndipo sikuyambitsa vuto la hypoglycemic.

Metformin imagwira ntchito m'njira zitatu:

kumabweretsa kuchepa kwa kupanga kwa shuga m'chiwindi chifukwa cha kuletsa kwa gluconeogenesis ndi glycogenolysis,
bwino minofu insulin kumva bwino mwa kusintha kutenga ndi kugwiritsa ntchito zotumphukira shuga
Iachedwetsa mayamwidwe am'matumbo m'matumbo.

Metformin imathandizira kapangidwe ka glycogen mu intracellular mwa kuchita glycogen synthetases. Kuchulukitsa kuchuluka kwa mayendedwe amitundu yonse ya ma membrane glucose transport (GLUT).

Pogwiritsa ntchito metformin, kulemera kwamthupi la wodwalayo kunakhazikika kapena kumachepetsa. Kuphatikiza pakukhudza kuchuluka kwa shuga m'magazi, metformin imakhudza metabolism ya lipid.

Zogulitsa. Mutatenga metformin, imangokhala yodzaza ndi gawo logaya chakudya, 20-30% imachotsera ndowe. Nthawi yofika ndende yayikulu (T _max ) ndi maola 2,5. Bioavailability pafupifupi 50-60%.

Ndi chakudya chofananacho, kuyamwa kwa metformin kumachepa ndikuchepera.

Kugawa. Kumanga kwa mapuloteni a Plasma ndikosatheka. Metformin imalowa m'magazi ofiira. Kuchulukitsa kwambiri m'magazi kumakhala kocheperachepera m'madzi a m'magazi, ndipo kumafikiridwa pafupifupi nthawi yomweyo. Maselo ofiira nthawi zambiri amayimira chipinda chogawirako chachiwiri. Voliyumu yapakati yogawa (V _d ) zimasiyanasiyana pamtunda wa malita 63-276.

Kupenda. Metformin imachotsedwa mu mkodzo osasinthika. Palibe ma metabolites omwe amapezeka mwa anthu.

Pomaliza Kutsimikizika kwa impso ndi> 400 ml / min, zomwe zikuwonetsa kuti metformin imachotsedwera chifukwa cha kusefera kwa madzi ndi kubisala kwa tubular. Pambuyo kumwa, theka-moyo pafupifupi 6.5 maola. Mu vuto la impso, kutsekeka kwa impso kumatsika molingana ndi kupezeka kwa creatinine chilolezo, motero kuthetsa theka la moyo kumawonjezeka, komwe kumabweretsa kuwonjezeka kwa plasma metformin.

Type 2 shuga mellitus (osadalira insulini) osagwiritsa ntchito mankhwalawa pakudya komanso machitidwe olimbitsa thupi, makamaka kwa odwala onenepa kwambiri

monga monotherapy kapena kuphatikiza mankhwala molumikizana ndi ena othandizira pakamwa a hypoglycemic kapena molumikizana ndi insulin pochizira akuluakulu.
monga monotherapy kapena kuphatikiza mankhwala omwe ali ndi insulin pochiza ana opitirira zaka 10.

Kuchepetsa zovuta za matenda a shuga kwa anthu akuluakulu omwe ali ndi matenda a shuga a 2 komanso onenepa kwambiri, ngati mankhwala oyambira mzere woyamba wokhala ndi mankhwala osagwira ntchito.

Contraindication

Hypersensitivity kuti metformin kapena china chilichonse cha mankhwala,
matenda ashuga ketoacidosis, matenda ashuga,
Aimpso kulephera kapena mkhutu aimpso ntchito
zovuta pachimake ndi chiopsezo cha aimpso kukanika, monga:

kuperewera kwa madzi m'thupi, matenda opatsirana opatsirana, mantha

matenda owopsa komanso osachiritsika omwe angayambitse kukula kwa hypoxia:

kulephera kwa mtima kapena kupuma, kubowoleza kwaposachedwa kwaposachedwa, kugwedezeka

Kulephera kwa chiwindi, poyizoni wauchidakwa, uchidakwa.

Kuyanjana ndi mankhwala ena ndi mitundu ina yoyanjana

Kuphatikiza sikulimbikitsidwa.

Kumwa mowa kwambiri Amaphatikizidwa ndi chiopsezo chowonjezeka cha lactic acidosis, makamaka ngati akusala kapena kutsatira zakudya zochepa zopatsa mphamvu, komanso kulephera kwa chiwindi.

Iodini wokhala ndi zinthu za radiopaque kungayambitse kukula kwa lactic acidosis kwa odwala omwe ali ndi matenda osokoneza bongo motsutsana ndi maziko a magwiridwe antchito olephera. Kugwiritsa ntchito mankhwalawa kuyenera kuyimitsidwa maphunzirowa asanayambenso ndipo sayenera kuyambiranso kupitilira maola 48 mutatha kafukufukuyu pogwiritsa ntchito zinthu za radiopaque ndikuwunika kwa impso.

Kuphatikiza kuyenera kugwiritsidwa ntchito mosamala.

Mankhwala omwe ali ndi vuto la hyperglycemic (GCS of systemic and local action, sympathomimetics, chlorpromazine) . Ndikofunikira kuyang'anitsitsa kuchuluka kwa shuga m'magazi, makamaka kumayambiriro kwa chithandizo. Munthawi yotsiriza komanso yothandizayi itatha, ndikofunikira kusintha mlingo wa metformin motsogozedwa ndi glycemia.

Ma diuretics, makamaka zida zotulutsa, achulukitse chiopsezo cha lactic acidosis chifukwa kuchepa kwa impso.

Zolemba zogwiritsira ntchito

Lactic acidosis ndizosowa koma zovuta kwambiri za metabolic zomwe zimatha kuchitika chifukwa cha kuphatikizika kwa metformin hydrochloride. Nkhani za lactic acidosis zanenedwa kwa odwala omwe ali ndi matenda osokoneza bongo, omwe amalephera kwambiri aimpso. Zowopsa za lactic acidosis: matenda osokoneza bongo osayendetsedwa bwino, ketosis, kusala kudya kwa nthawi yayitali, kumwa kwambiri mowa, kulephera kwa chiwindi, kapena vuto lililonse lomwe lingakhale ndi hypoxia.

Lactic acidosis imatha kuchitika ngati minofu kukokana ndi kupweteka kwam'mimba komanso asthenia yayikulu. M'tsogolomu, kukula kwa dyspnea acidic, kupweteka kwam'mimba, hypothermia ndi chikomokere ndikotheka. Zizindikiro zakuzindikira zimaphatikizapo kuchepa kwa labot mu magazi pH, kuwonjezeka kwa kuchuluka kwa lactate mu seramu yamagazi pamtunda wa 5 mmol / l, kuchuluka kwa anion ndi gawo la lactate / pyruvate. Ngati mukukayikira lactic acidosis, muyenera kusiya kugwiritsa ntchito mankhwalawo ndikuperekera kuchipatala wodwala nthawi yomweyo.

Kulephera kwina . Popeza metformin imachotsedwa impso, isanachitike komanso isanachitike mankhwala a metformin, ma serum creatinine ayenera kuyang'aniridwa:

odwala aonekera aimpso ntchito osachepera 1 pachaka,
odwala aimpso kuwonongeka ndi okalamba odwala osachepera 2-4 pachaka.

Chenjezo liyenera kugwiritsidwa ntchito ngati matenda a impso angadwalidwe, mwachitsanzo, kumayambiriro kwa chithandizo cha mankhwala a antihypertensive, okodzetsa, komanso kumayambiriro kwa mankhwala a NSAID.

Ma ayodini okhala ndi ayodini . Kugwiritsa ntchito ma radiopaque mwakutsata kumatha kuyambitsa kulephera kwa impso, chifukwa chake, kuwerengetsa kwa metformin komanso kukula kwa lactic acidosis. Chifukwa chake, kutengera ntchito ya impso, kugwiritsa ntchito metformin kuyenera kuyimitsidwa maola 48 isanachitike kapena panthawi yophunzirayo ndipo osakonzedwanso kale kuposa maola 48 mutatha kuphunzira ndi kuwunika kwa impso.

Opaleshoni . M'pofunika kuletsa kugwiritsa ntchito mankhwalawa maola 48 musanachitike opaleshoni yofunikirayi, musanachitike opaleshoni yovomerezeka, ya msana kapena yowonjezera ndipo musayambenso kuyambika kale kuposa maola 48 mutagwira ntchito ndikuwunika kwa aimpso.

Ana ndi achinyamata . Musanayambe chithandizo ndi metformin, kuwunika kwa mtundu wachiwiri wa shuga kuyenera kutsimikiziridwa. Malinga ndi zotsatira za kafukufuku wazachipatala, zotsatira za metformin pa kukula ndi kutha kwa ana sizinawululidwe. Komabe, palibe deta pazotsatira za kukula kwa metformin komanso kutha msambo pogwiritsa ntchito nthawi yayitali, chifukwa chake, kuwunikira mosamala magawo awa azaka zapakati pa 10-12, omwe amathandizidwa ndi mankhwalawa, makamaka panthawi yakutha msuzi, akulimbikitsidwa.

Njira zina . Odwala ayenera kutsatira zakudya, kudya yunifolomu yanga tsiku lonse. Odwala onenepa kwambiri ayenera kupitiliza kutsatira zakudya zamafuta ochepa. Ndikofunikira kuwunika pafupipafupi zowonetsa ma labotale.

Ndi kugwiritsa ntchito pamodzi kwa metformin ndi insulin kapena mankhwala ena amkamwa hypoglycemic (mwachitsanzo, sulfonylureas kapena meglitinide), kuchuluka kwa zotsatira za hypoglycemic ndikotheka.

Gwiritsani ntchito pa nthawi yoyembekezera kapena mkaka wa m'mawere.

Matenda osagwirizana ndi matenda a shuga panthawi yomwe ali ndi pakati (gestational kapena kulimbikira) amawonjezera mwayi wokhala ndi vuto lobadwa nalo komanso kufa kwa perinatal.

Kuyamwitsa. Metformin amachotseredwa mkaka wa m'mawere. Mwa makanda / makanda, mavuto sanawoneke. Komabe, popeza palibe chidziwitso chokwanira pa mankhwalawa, kuyamwitsa sikulimbikitsidwa panthawi ya metformin. Lingaliro la kusiya kuyamwitsa liyenera kuchitika chifukwa chakufunika kotenga mankhwalawa kwa mayi ndi chiwopsezo cha mwana.

Chonde . Metformin sizinakhudze chonde amuna ndi akazi pomwe amagwiritsidwa ntchito mu Mlingo wa 600 mg / kg / tsiku, lomwe linali lokwera pafupifupi katatu kuposa mlingo waukulu wa tsiku lililonse, womwe umalimbikitsa anthu kuti ugwiritse ntchito ndipo umawerengeredwa potengera thupi.

Kutha kukopa momwe zinthu zikuyendera mukamayendetsa magalimoto kapena njila zina.

Mankhwalawa sakukhudzanso kuchuluka kwa magalimoto pamene mukuyendetsa magalimoto kapena njira zina, popeza monotherapy yokhala ndi metformin siyimayambitsa hypoglycemia.

Komabe, metformin iyenera kugwiritsidwa ntchito mosamala kuphatikiza ena othandizira a hypoglycemic (sulfonylureas, insulin, repaglinide, meglitinides) chifukwa choopsa cha hypoglycemia.

Mlingo ndi makonzedwe

Monotherapy kapena kuphatikiza mankhwalawa molumikizana ndi ena othandizira pakamwa.

Akuluakulu . Nthawi zambiri, muyeso woyamba wa 500 mg kapena 850 mg 2-3 kawiri pa tsiku mukamadya kapena mutatha kudya.

Pambuyo masiku 10-15 chithandizo, mlingo uyenera kusinthidwa malinga ndi zotsatira za miyeso ya seramu glucose.

Kuchepetsa pang'onopang'ono kwa mlingo kumachepetsa mavuto kuchokera m'mimba.

Mlingo woyenera kwambiri ndi 3000 mg patsiku, womwe umagawidwa pazigawo zitatu.

Pankhani ya kusintha kwa mankhwalawa ndi metformin, ndikofunikira kusiya kumwa mankhwala othandizira ena.

Kuphatikiza mankhwala ndi insulin .

Kuti akwaniritse bwino kuchuluka kwa shuga m'magazi, metformin ndi insulin zitha kugwiritsidwa ntchito ngati mankhwala osakanikirana.

Monotherapy kapena mankhwala ophatikizira limodzi ndi insulin.

Ana . Gwiritsani ntchito metformin kwa ana opitilira zaka 10. Nthawi zambiri, koyamba mlingo ndi 500 mg kapena 850 mg kamodzi tsiku lililonse panthawi kapena chakudya. Pambuyo masiku 10-15 chithandizo, mlingo uyenera kusinthidwa malinga ndi zotsatira za miyeso ya seramu glucose.

Kuchepetsa pang'onopang'ono kwa mlingo kumachepetsa mavuto kuchokera m'mimba.

Mlingo woyenera kwambiri ndi 2000 mg patsiku, womwe umagawidwa mu 2-3 Mlingo.

Odwala okalamba kuwonongeka kwa impso ndizotheka, motero, mlingo wa metformin uyenera kusankhidwa potengera kuyesedwa kwa aimpso, womwe uyenera kuchitidwa pafupipafupi (onani Gawo " Zolemba zogwiritsira ntchito »).

Mankhwalawa amatha kugwiritsidwa ntchito pochiza ana azaka zapakati pa 10.

Bongo

Pogwiritsa ntchito mankhwalawa mlingo wa 85 g, kukula kwa hypoglycemia sikunachitike. Komabe, pankhaniyi, kukula kwa lactic acidosis kunawonedwa. Pankhani ya lactic acidosis, chithandizo chiyenera kuyimitsidwa ndipo wodwala amapita kuchipatala mwachangu. Njira yothandiza kwambiri yochotsa lactate ndi metformin kuchokera mthupi ndi hemodialysis.

Zambiri pazamankhwala a hypoglycemic

Wothandizidwa ndi hypoglycemic ali ndi mankhwala othandizira, metformin hydrochloride, omwe ndiye woimira kalasi yayikulu. Kutengera mtundu wa Mlingo, mapiritsi amapangidwa omwe amaphatikiza ndi 500 kapena 850 mg ya mankhwala othandizira. Kuphatikizika kwa zamankhwala zam'mimba zimagwirizanitsidwa ndi mphamvu yolepheretsa kupanga kwa glucose kuchokera ku mankhwala osagwiritsa ntchito chakudya (gluconeogeneis).

Kuphatikiza pa metformin hydrochloride, piritsi limodzi la mankhwalawa limakhala ndi wowuma sodium, magnesium stearate, silicon dioxide, colloidal anhydrous, Copolyvidone Va64 ndi cellcrystalline cellulose.

Mankhwalawa samatulutsa popanga mahomoni ochepetsa shuga, chifukwa chake anthu athanzi omwe amamwa mankhwalawa samva zizindikiro za hypoglycemia. Pakati pazabwino za mankhwalawa, ndikofunikira kufotokoza izi:

Kuponderezedwa kwa gluconeogeneis.
Kuchuluka kwa chiwopsezo cha maselo olimbana ndi insulin.
Kukopa kwa glucose komwe kumachitika ndi myocyte.
Kuchepetsa thupi, makamaka mwa anthu onenepa.
Kutsika kwa zonse shuga ndi zomwe zimadya mutatha kudya.
Zabwino pa lipid metabolism (kuchepa kwa cholesterol, triglycerides ndi LDL).
Kuchepera kwa njala.
Kulimbikitsa anaerobic glycolysis.
Kuchedwa kuyamwa kwa matumbo m'matumbo.

Wothandizira antidiabetes amatengedwa mkati, kuphatikiza kwakukulu kumawonedwa pambuyo maola 2,5. Kuperewera kwa chigawo chachikulu kumachitika m'mimba.

Metformin hydrochloride imachotsedwera mawonekedwe osasintha ndi mkodzo.

Malangizo ogwiritsira ntchito mapiritsi

Monga tanena kale koyambirira, mankhwalawa amatha kugwiritsidwa ntchito ngati odwala matenda a shuga a insulin komanso osadalira insulin. Ndi dokotala yekhayo amene angatchule mlingo woyenera wa mankhwalawa, potengera kuchuluka kwa shuga ndi zina zokhudzana ndi wodwalayo.

Pogula mankhwala, wodwalayo sayenera kutsatira malingaliro a dokotala, komanso adziwitse yekha ndi ma phukusi. Ngati mafunso abuka, ayenera kufunsidwa ndi akatswiri azachipatala.

Kumayambiriro kwa mankhwalawa, mlingo wotsika tsiku lililonse umasankhidwa - 500 kapena 1000 mg yokha. Pakatha milungu iwiri, adotolo amatha kuonjezera mlingo wa mankhwalawo, chifukwa cha zomwe zili m'magazi. Mankhwala oyamba ndi mankhwalawa akhoza kutsagana ndi kuphwanya kwam'mimba. Zizindikiro zosasangalatsa zoterezi zimafotokozedwa ndikusintha kwa thupi ndi chinthu chogwira ntchito ndipo patatha masiku 10-14 zimadutsa zokha. Kuti mukhale ndi shuga wabwinobwino, muyenera kudya 1,500-2,000 mg patsiku. Mlingo waukulu kwambiri ndi 3000 mg. Kuti muchepetse zotsatira zoyipa za mankhwalawa m'matumbo oyambira, muyenera kugawa mankhwalawo kangapo.

Kuphatikiza Metformin Sandoz ndi insulin, kuchepetsedwa kothandiza kwambiri kwa anthu omwe ali ndi shuga kumatha kuchitika. Mankhwalawa amatengedwa kawiri kapena katatu patsiku 500 mg. Ponena za kuchuluka kwa insulin, zimatengera kuchuluka kwa shuga m'magazi.

Anthu odwala matenda ashuga okalamba omwe amagwiritsa ntchito Metformin Sandoz amafunikira chisamaliro chapadera. Dokotalayo ndi amene amawona muyezo wa mankhwalawa, chifukwa cha impso.

Pogula mankhwala, munthu sayenera kuyiwala za kuyang'ana tsiku lotha ntchito, lomwe nthawi zambiri limakhala zaka 5.

Mankhwalawa amasungidwa m'malo owuma pamtunda wosaposa 25 digiri Celsius.

Metformin Sandoz: Zochita Zamankhwala

Tiyenera kukumbukira kuti mankhwalawa amatha kuwonjezera kapena kuchepetsa Hypoglycemic zotsatira za mankhwalawa. Ena angayambitse lactic acid chikomokere.

Pankhani imeneyi, katswiri wothandizirayo ayenera kudziwa matenda onse omwe wodwalayo akumakumana nawo kuti apewe mavuto. Wodwalayo, sayenera kuletsa dokotala zina zamankhwala kupatula shuga.

Chifukwa chake, m'munsimu muli mayina a mankhwala omwe amachepetsa mphamvu ya mankhwalawa, motero kuwonjezeka kwa glycemia mwa odwala:

Danazole
Chlorpromazine
antipsychotic
glucagon,
mahomoni a chithokomiro,
thiazide okodzeya,
nicotinic acid zotumphukira,
amphanomachul
Mankhwala a estrogen-progestogen
beta-2-adrenergic zolandilira,
glucocorticosteroids am'deralo komanso mwatsatanetsatane kanthu.

Pali mitundu ingapo ya mankhwala omwe, m'malo mwake, imathandizira Hypoglycemic zotsatira za wothandizila wodwala. Izi zikuphatikiza:

Acarbose.
Kutenga nthawi yayitali komanso kuchita insulin pang'ono.
Beta-2 adrenergic olimbana nawo.
Mao ndi ACE zoletsa.
Zothandiza kuchokera ku sulfonylureas.
Salicylates.
Zothandiza pofikira.
NSAIDs.
Cyclophosphamide, komanso zotumphukira zake.
Oxytetracycline.

Amawonjezera mwayi wa lactic acidosis kumwa mankhwala ndi mowa komanso mankhwala okhala ndi ethanol, mankhwala okhala ndi ayodini omwe amaphatikizira ena, cimetidine ndi diuretics.

Mtengo wa mankhwalawa, ndemanga ndi fanizo

Mankhwalawa atha kugulidwa ku mankhwala aliwonse omwe mumalandira ndi dokotala. Kuti musunge ndalama, mankhwalawo amalamulidwa patsamba logula lazogulitsa.

Pafupifupi, mtengo wa mankhwalawo umasiyanasiyana kuchokera ku ruble 230 mpaka 800, kutengera mtundu wa kumasulidwa. Chifukwa chake, othandizira odwala matenda ashuga amapezeka m'magulu onse a anthu, omwe, ndi mwayi wawo.

Pa intaneti, mutha kupeza ndemanga zambiri zabwino kuchokera kwa odwala omwe amamwa mankhwalawa. Imatsika bwino ndipo imakhazikika m'magulu a shuga. Zimathandizanso kutaya mapaundi owonjezera pama diabetes a onenepa. Wothandizirana ndi hypoglycemic monga mapiritsi ndiosavuta kutenga. Kuphatikiza apo, sikuti zimayambitsa zovuta (kuwonjezera pakusokoneza pamimba).

Komabe, palinso ndemanga zoyipa za mankhwalawa. Amalumikizidwa ndi vuto logaya chakudya lomwe limapezeka munthawi yophatikiza thupi kuti lizigwira ntchito. Mwa odwala ena, zizindikiro zotere zimadziwika kuposa zina, motero amayenera kuyika mankhwala ena othandizawa ndi mankhwala ena.

Madokotala salimbikitsa kuti munthu azitha kumwa mankhwalawo kuti akhale ndi thanzi labwino. Ndi zoletsedwa kumwa zakumwa zoledzeretsa pamankhwala.

Nthawi zina madokotala amayenera kusintha njira yochiritsira odwala. Izi zitha kukhala chifukwa chosintha mosiyanasiyana. M'malo mankhwala osagwirizana akhoza kukhala njira zomwe zimakhala ndi chinthu chimodzi, kapena chimodzimodzi.

Metformin hydrochloride ndi gawo lodziwika bwino padziko lapansi, chifukwa chake limagwiritsidwa ntchito popanga mankhwala ambiri a hypoglycemic. Ndizosadabwitsa kuti Metformin Sandoz ali ndi mitundu yambiri ya mitundu, yomwe pali:

Gliformin (ma ruble 112).
Metformin-Teva (136 ma ruble),
Glucophage (ma ruble 223).
Metformin Richter (ma ruble 183),
Metfogamma 850 (134 ma ruble), Metfogamm 1000 (168 ma ruble).
Metformin Zentiva (134 ma ruble).
Siofor (ma ruble 245).
Metformin Canon (ma ruble 172).
Formetin (ma ruble 100).

Monga mukuwonera, Metformin Sandoz ndi mankhwala othandizadi omwe amachotsa zizindikiro za hyperglycemia ndi matenda a shuga mwa odwala akuluakulu. Pogwiritsa ntchito mankhwalawa moyenera, mutha kukhala ndi glycemia wabwinobwino kwa nthawi yayitali.

Akatswiri adzakuwuzani za zomwe Metformin amachita pazomwe zimayambitsa matenda ashuga zomwe zili muvidiyo ino.

Njira yamachitidwe

Metformin kapena dimethylbiguanide ali m'gulu la mankhwala antidiabetesic, biguadins.

Kodi Metformin imachepetsa bwanji magazi? Ndikofunika kudziwa kuti mawu awa si olondola konse, kuchuluka kwa shuga sikusintha, koma kumangogawidwanso osati kupangidwanso. Izi zimachitika chifukwa cha machitidwe angapo. Choyamba, Metformin imalepheretsa kupanga shuga m'thupi. Mosiyana ndi zimenezo, kumawonjezera kuvunda kwake. Izi zimachitika chifukwa Metformin imalepheretsa kupangidwa kwa mphamvu ndi mpweya m'maselo omwe amapanga glucose, chifukwa pomwe glucose imawonongeka popanda kutenga mpweya. Glucose amalowa m'maselo kuchokera kumalo achilendo, ndipo maselo amalandila kuchuluka kwa glucose, ndipo gawo lochulukirapo limangowonongeka.

Komanso Metformin, malangizo ogwiritsira ntchito, amafotokozera mwatsatanetsatane, amathandizira kudya kwa masitolo a glycogen m'chiwindi osachepetsa kuchuluka kwa shuga m'magazi. Likukhalira kuti Metformin imangothandiza kugawa glucose komwe ikufunika, imalepheretsa mapangidwe a glucose owonjezera ndipo sizitengera kusintha kwa kuchuluka kwa shuga m'thupi.

Pakati pa matenda a shuga, kuchuluka kwamafuta acids kumawonjezeka, ndipo kulemera kwa thupi kumakwera. Metformin imalepheretsa mapangidwe amafuta achilengedwe. Komanso kunenepa kwambiri kumatha kuchitika chifukwa cha kuchuluka kwambiri kwa insulin, chifukwa cha Metformin, kuchuluka kwa insulin kumachepetsedwa. Njira imeneyi ndi yofunikira kwambiri popewa zovuta pamatumbo a thupi.

Metformin imathandizira chidwi cha maselo a thupi kulowa insulin, izi zimathandiza kuyamwa glucose ku ziwalo ndi minyewa yomwe imadwala chifukwa cha kusowa kwa glucose panthawi ya matenda ashuga. Mukamagwiritsa ntchito mankhwalawa kwa nthawi yoposa chaka, wodwalayo amamva kuchepa kwakudya komanso kunenepa kwambiri.

Metformin imafinya magazi, imachepetsa mulingo wamafuta oyipa, imalepheretsa makulidwe amitsempha yamagazi. Izi zikusonyeza kufunikira kwa Metformin popewa zovuta zamatenda a shuga. Chifukwa chake, Metformin imachedwetsa kuyambika kwa matenda ashuga angiopathy. Chifukwa chake mutha kuweruza kuchuluka kwa chiwopsezo cha matenda ashuga kapena matenda am'mimba mtsogolo mwakuwerengera cholozera cha SCORE, ngati cholesterol imatsika, chiopsezo chimachepa.

Metformin, malangizo ogwiritsira ntchito, izi zikuwonetsa kusintha pang'onopang'ono kusinthika kwa matenda ashuga, kuchita zonse zokhudzana ndi matendawa.

Mutatha kumwa mankhwalawo, zomwe zimakhala m'magazi zimawonedwa pambuyo pa maola 2-2,5.

Kudya zolondola za Metformin pokhapokha musanadye, chifukwa ngati simunatero imakhala yolimba kwambiri m'matumbo ndipo sichingafikire pamankhwala omwe achire amachitika.

Ndikofunika kukumbukira kuti kumwa mankhwala othandizira odwala matenda ashuga kumamveka pokhapokha ngati wodwalayo akupitiliza kutsatira zakudya zotchulidwa ndi endocrinologist ndipo samachita zinthu zongokhala, amachita masewera, amachita masewera olimbitsa thupi.

Zizindikiro zogwiritsidwa ntchito

Metformin ndi mankhwala osiyanasiyana, kuphatikiza pa matenda ashuga m'zaka zaposachedwa, zotulukapo zake pama matenda ena ambiri apezeka.

Zisonyezero zogwiritsidwa ntchito:

Type 2 shuga mellitus, mankhwala amodzi yekhayo kapena osakanikirana ndi mankhwala ena amkamwa a antiidiabetes a magulu ena kapena a insulin,
Type 2 matenda a shuga komanso kunenepa kwambiri. Panthawi yomwe sizingatheke kuletsa matenda ashuga osagwiritsa ntchito mankhwala osokoneza bongo (masewera olimbitsa thupi ndi zakudya).

Ntchito yoyesera

Posachedwa, Metformin yakhala ikugwiritsidwa ntchito kwambiri pakumayesa matenda am'mimba a polycystic, matenda osokoneza bongo a mafuta osokoneza bongo, kutha msanga ndi matenda ena okhudzana ndi insulin kukana, monga acromegaly, hypercorticism.

Palibe zambiri zenizeni komanso lingaliro la sayansi pazokhudza Metformin pamatenda omwe atchulidwa pamwambapa, madokotala ena amati pambuyo pakupereka Metformin, kuchuluka kwa glucose ndi insulin kumachepa, koma izi sizokwanira kuphatikiza mankhwalawo mu protocol yovomerezeka pakuchiza matendawa.

Metformin ya polycystic ovary yochizira kukondoweza kwa ovulation imakhalabe yosavomerezeka, chifukwa maphunziro ambiri pazokhudza kubereka apeza zotsatira zolakwika zingapo. Madokotala ena, omwe amagwiritsa ntchito Metformin ya polycystic ovary ndi sekondale ya shuga, amawona kuwonjezeka kwa amayi omwe akutenga Metformin, mosiyana ndi omwe satero. Komabe, clomiphene kale amagwiritsidwa ntchito polimbikitsa ovulation.

MD Anderson Cancer Center adachita kafukufuku wamkulu yemwe adawonetsa zotsatira za Metformin popewa khansa ya kapamba. Zotsatira za phunziroli zidawonetsa kuti kuchepa kwa 62% pangozi yotenga khansa ya kapamba mwa otenga nawo mbali omwe adatenga Metformin poyerekeza ndi gulu la odwala omwe sanatenge. Izi zidapangitsa kukhazikitsidwa kwa kafukufuku watsopano komanso kukhazikitsa pulogalamu yoletsa khansa ya kapamba.

Kutenthetsa kwa Metformin

Masiku ano, yatchuka pakati pa anthu onenepa kwambiri komanso onenepa kwambiri popanda matenda ashuga kuti atenge Metformin ngati njira yochepetsera kunenepa. Pali njira ina yothandizira ndi Metformin kuti muwotche thupi kwambiri. Endocrinologists samalangiza wodwala wawo kuti atenge Metformin popanda matenda a shuga komanso kuchepa kwa chidwi cha maselo kuti apange insulin. Malangizo ogwiritsira ntchito lembani za izi. Koma nthawi zambiri, odwala amachita izi popanda kufunsa dokotala. Izi ndizoyipa kwambiri.

Kulephera kutsatira zakudya zoyenera ndi shuga wambiri, osazindikira kuchuluka kwa mankhwalawa kumatha kubweretsa zovuta zambiri, izi ndizo. Kachiwiri, zikuwonetsedwa kuti Metformin sikukhudza kuchuluka kwa shuga m'magazi athanzi, zomwe zikutanthauza kuti chinthu chokhacho chothandiza kuchepetsa kuchuluka kwamafuta ndizomwe zingagwire ntchito pamenepa.

Metformin yochepetsa thupi, makamaka popanda mankhwala a dokotala, imatsutsana.

Dokotala amatha kupereka mankhwala pokhapokha ngati ali ndi matenda a prediabetes kapena insulin. Koma ngakhale zili choncho, kudya ndi kuchita masewera olimbitsa thupi ndizothandiza kwambiri kuposa mankhwala omwe Metformin ali. Malangizo ogwiritsira ntchito samalongosola momwe mankhwalawa amathandizira kuchepetsa thupi.

Malangizo ogwiritsira ntchito, kukhazikitsa mlingo wofunikira

Mankhwala amatengedwa pakamwa ndikutsukidwa ndi madzi. Ngati piritsi ndi 850 mg - zitha kukhala zovuta kumeza, mutha kugawa piritsi lanu magawo awiri. Ngati mavuto akuwoneka pambuyo pa makonzedwe, kuti athandizire kupumula, tsiku ndi tsiku mlingo ungagawanike pawiri.

Mlingo wocheperako tsiku lililonse ndi gramu imodzi, mlingo waukulu patsiku ndi magalamu atatu. Masabata awiri kapena atatu atapangidwa ndi mankhwalawa, mlingo umatha kuchuluka. Ntchito yonse ya mankhwalawa ndi zotsatira zake zimawonedwa patatha masiku 10-15.

Ngati mukufunikira kuyamba kumwa Metformin m'malo mwa mankhwala ena okhudzana ndi matenda ashuga, muyenera kusiya kumwa mankhwala oyamba, kenako ndikumayamba Metformin, malinga ndi mlingo.

Mlingo wa insulin uyenera kuchepetsedwa ngati waperekedwa pamodzi ndi metformin. Mankhwala onsewa amatha kutulutsa mphamvu za wina ndi mnzake.

Pharmacokinetics

Pang'ono odzipereka kuchokera m'mimba thirakiti. Kuzindikira kwakukulu kumatha kutsimikiziridwa pambuyo maola 1.5-2. Kulandila kumawonjezera nthawi mpaka maola 2,5. Zinthu zomwe zimagwira zimatha kudziunjikira impso ndi chiwindi. Kuchotsa theka-moyo ndi 6 maola. Mukakalamba komanso kuwonongeka kwa impso, nthawi yochuluka kuchokera m'thupi imatalika.

Ndi matenda ashuga

Mlingo uyenera kusinthidwa ndi dokotala. Mlingo woyamba wa tsiku lililonse ndi piritsi limodzi. Mukakalamba, osaposa 1000 mg patsiku ayenera kumwedwa. Pambuyo masiku 10-15, mutha kuwonjezera kuchuluka kwake. Zambiri patsiku zimaloledwa kutenga 2,5 mg. Ndi matenda amtundu wa 1 shuga, kuchuluka kwa insulin kumatha kuchepetsedwa pakapita nthawi.

Dongosolo la Endocrine

Pali kuchepa kwa kuthamanga kwa magazi ndi kuchuluka kwa shuga m'magazi, kupweteka kwa minofu, kugona.

Dermatitis imatha kuchitika.

Mutatenga Metformin 850, kutsika kwa magazi nthawi zina kumachitika.

Malangizo apadera

Mankhwalawa, ndikofunikira kuyang'ana momwe chiwindi chikugwirira ntchito, impso ndikuwunika kuchuluka kwa shuga m'magazi (makamaka mukaphatikizidwa ndi insulin ndi zotumphukira za sulfonylurea).

Yogwira pophika mankhwala imapangitsa kuyamwa kwa vitamini B12.

Kwa kupweteka kwa minofu, ndikofunikira kudziwa mulingo wa lactic acid m'madzi a m'magazi.

Kuchita ndi mankhwala ena

Njira yochepetsera shuga m'magazi imachepetsa ngati mutatenga GCS, glucagon, progestogens, mahomoni a chithokomiro, thiazide diuretics, adrenaline, mankhwala omwe ali ndi adrenomimetic kwenikweni, estrogens, antipsychotic (phenothiazines). Chosakaniza chophatikizacho sichigwirizana bwino ndi cimetidine chifukwa chotupa cha lactacidemia.

ACE zoletsa ndi monoamine oxidases, sulfonylureas, clofibrate zotumphukira, cyclophosphamide, beta-blockers, NSAIDs imatha kupititsa patsogolo zotsatira za hypoglycemic. Kuphatikiza kwa Danazol ndi mitundu yosiyanitsa yomwe imakhala ndi ayodini ndiwotsutsana.

Kulandila sikumaperekedwa pokhapokha ngati chiwindi chayamba kugwira ntchito.

Imwani pa kumwa mankhwala kudalira, incl. pamodzi ndi madontho ndizoletsedwa.

Kuchuluka kwa zinthu zogwira ntchito m'madzi a m'magazi kumawonjezeka ndi 60% pomwe mukumwa Triamteren, Morphine, Amiloride, Vancomycin, Quinidine, Procainamide. Mankhwala a hypoglycemic safunikira kuphatikizidwa ndi cholestyramine.

Kuyenderana ndi mowa

Kumwa mowa kumawonjezera chiopsezo cha lactic acidosis. Ndikulimbikitsidwa kuti mowa usamayanjidwe panthawi yamankhwala.

Mu mankhwalawa mutha kupeza m'malo mwa mankhwalawa. Pali zochitika zina zamankhwala zomwe zimapangidwa ndi mankhwala:

Glyformin
Glucophage ndi Glucophage Long,
Metfogamma,
Fomu,
Siofor.

Mankhwala Metformin kuchokera kwa wopanga wina akhoza kukhala ndi Zentiva, Long, Teva kapena Richter phukusi. Musanalowe m'malo ndi analog, muyenera kudziwa kuchuluka kwa shuga, kupimidwa kuti mupeze matenda ena ndi kufunsa dokotala.

Metformin Richter: malangizo a mapiritsi

Mapiritsi a Metformin - mankhwala omwe ali ndi vuto la hypoglycemic, amatengedwa kuti awonjezere kumva kwa maselo kuti apange insulini ndikuchepetsa mayamwidwe a shuga m'matumbo.

Kugwiritsa ntchito Metformin Richter kukuwonetsedwa kwa matenda ashuga amtundu wa 2 pa vuto la kusakhala ndi chizolowezi chokhala ndi ketoacidosis (makamaka mwa anthu onenepa kwambiri) osakwanira pakuwona kadyedwe.

Kupanga ndi mafomu omasulira

Mankhwalawa (1 tabu.) Muli ndi chinthu chokhacho chomwe chimagwira metformin, kachigawo kake kachulukidwe kamakhala 500 mg ndi 850 mg. Zowonjezereka zimaperekedwa:

Magnesium Stearate
Polyvidone
Aerosil
Copovidone
MCC.

500 mg ndi mapiritsi a 850 mg ndi apamwamba, oyera. Mapiritsi amayikidwa m'matumba a 10 ma PC. Mkatikati mwa phukusi pali matuza 5.

Kuchiritsa katundu

Mothandizidwa ndi metformin, kuletsa kwa gluconeogenesis m'maselo a chiwindi kumayang'aniridwa, kuyamwa kwa glucose ndi matumbo a matumbo kumachepetsedwa, ndipo njira yake yogwiritsira ntchito njira zake imagwirira ntchito.

Nthawi yomweyo, kuwonjezereka kwa chiwopsezo cha minyewa kuchitira insulin kwalembedwa popanda kukhudza kupanga kwa insulin ndi ma cell a cell omwe amapezeka mu kapamba, chifukwa chomwe chitha kuchepetsa cholesterol yathunthu, LDL, ndi triglycerides m'magazi.

Kupanga kwakukulu kwamankhwala kumawonekera:

Kukhathamiritsa kwa dongosolo la kufalikira kwa glucose komanso kuchepa mayamwidwe mu chiwindi
Kuwongolera kwa mahomoni olimbikitsa chithokomiro
Kuletsa kwa gluconeogeneis
Kuchepa kwamphamvu kwa thrombosis
Kupititsa patsogolo njira yobwezeretsanso magazi kuwundana
Kutsitsa ma linoprotein ndi triglycerides
Kuthamangitsa makutidwe ndi okosijeni amitundu yambiri yamafuta
Matenda a cholesterol.

Pambuyo pa kugwiritsa ntchito mapiritsi, pamakhala kuyamwa mwachangu kwa chinthu chogwira ntchito m'mimba. Chizindikiro cha bioavailability sichidutsa 60%. Kuzungulira kwakukulu kwa plasma kulembedwa pambuyo pa maola 2,5. Mukamadya, phindu limatsitsidwa ndi 40% ndipo kukwaniritsa kwake kumalepheretsa pafupifupi mphindi 35.

Metformin imadziwika ndi kufalitsa mwachangu mkati mwa minofu, komanso kuchuluka kochepa kwa metabolic. Ubwenzi wa metformin wokhala ndi mapuloteni a plasma ndi ochepa.

Njira yochotsera ikuchitika ndi kutenga gawo la impso. Ndizofunikira kudziwa kuti theka la moyo ndi maola 6.5.

Metformin Richter: malangizo onse ogwiritsira ntchito

Mtengo: kuchokera ku 162 mpaka 271 rubles.

Mankhwala amawonongeka ndi chakudya kapena pambuyo pake. Mapiritsi ayenera kutsukidwa ndi madzi okwanira. Kuchepetsa kwambiri mwayi wokhala ndi zovuta zoyipa, ndimamwa mlingo wa tsiku lililonse wa 2-3 r.

Mlingo wa mankhwalawa amatsimikiziridwa payekhapayekha pogwiritsira ntchito index ya glucose.

Chithandizo cha mapiritsi okhala ndi mulingo wa ma milligram 500: yambani mankhwalawa tsiku lililonse ndi 0,5-1 g. Patatha masiku 10-15. Mlingo ukuwonjezeka pambuyo poyendetsa shuga. Nthawi zambiri, mankhwalawa pokonza tsiku ndi tsiku samapitilira 1.5-2 g, apamwamba kwambiri - 3 g.

Kugwiritsa ntchito mapiritsi omwe ali ndi mulingo wa mamiligalamu 850: m'masiku oyamba a mankhwalawa, tikulimbikitsidwa kutenga 850 mg ya metformin patsiku. Pambuyo masiku 10-15. adokotala angakulimbikitseni kuchuluka kwa mlingo wanu. Mankhwala akukonza, tsiku lililonse mankhwala a metformin amatengedwa kuchuluka kwa 1.7 g. Mlingo wapamwamba kwambiri sayenera kupitirira 2.55 g.

Odwala okalamba salimbikitsidwa kudya oposa 1 g ya metformin patsiku.

Pankhani ya zovuta zazikulu za kagayidwe kachakudya, mwayi wa lactic acidosis umachulukirapo, momwe mungathandizire kuchepetsa mlingo wa mankhwalawa.

Zotsatira zoyipa

Zotsatira zoyipa za Metformin ndizosowa kwambiri, nthawi zambiri kumwa mankhwalawa ndikosavuta kwa wodwala. Zotsatira zoyipa ndizambiri:

nseru
kusanza
kutentha kwa mtima
kutulutsa ndi kupweteka m'mimba,
kuchepa kwamtima
kumva kukoma kwazitsulo mkamwa.

Nthawi zambiri, zizindikirozi zimayamba ndi milingo yoyamba ya mankhwalawa ndikuwonekera msanga, ngakhale simusintha mlingo wa Metformin.

Osowa kwambiri, anthu omwe ali ndi vuto la kuphatikizika kwa mankhwalawa amatha kukumana ndi mawonekedwe a erythema pakhungu. Poterepa, ndikofunikira kulingalira njira yothanirana ndikusinthira ina. Mankhwala a Anaphylactic kapena Quincke edema sanawonedwe ndi Metformin.

Osati kawirikawiri, Metformin, malangizo ogwiritsira ntchito polemba izi, angayambitse kukula kwa lactic acidosis. Chifukwa chake, wodwalayo ayenera kufunsa dokotala pafupipafupi kuti apenye.

Megaloblastic anemia kapena kuchepa kwa vitamini B12 kumatha kukhala mozungulira mozungulira kwa odwala omwe amatenga Metformin kwa nthawi yayitali komanso mwa odwala omwe ali ndi matenda oopsa a m'mimba thirakiti ndipo atatha kuyamwa kwathunthu m'mimba. Zizindikiro za megaloblastic anemia: kufinya pakhungu ndi mucous nembanemba, kufooka wamba, kuuma ndi kupindika kwa khungu, kuchepa tsitsi, kumva miyendo ya thonje.

Odwala omwe ali ndi hypothyroidism, kuchepa kwa mitundu ya mtundu wa antiotropic ndikotheka. Nthawi zina, pakhoza kukhala kuchepa kwa testosterone secretion mwa amuna. Kwambiri, zotsatira ziwiri zomaliza sizinatsimikizidwe.

Zizindikiro ndi kuopsa kwa bongo

Mankhwala osokoneza bongo a Metformin ndi osowa kwambiri. M'mabukuwo, mutha kupeza tanthauzo limodzi lokha mukamamwa mankhwalawa 75g. Nthawi yomweyo, kuchuluka kwa shuga sikunasinthe, koma lactic acidosis inayamba - mkhalidwe wowopsa kwambiri momwe mulingo wa lactate m'magazi umakwezeka kuposa 5 mmol / l. Zizindikiro zoyambira zitha kukhala:

chizungulire
mutu mpaka isanayambike migraine,
malungo
zosokoneza pakupuma
nseru
kusanza
kutsegula m'mimba
kupweteka m'mimba
spasms m'minyewa ya miyendo.

Milandu ingapo ikhoza kubweretsa kukhazikitsidwa kwa chikomokere ndi kufunika kolumikizana ndi mpweya wabwino.

Ngati muli ndi zizindikiro zotere, ndikofunikira kuchipatala wodwalayo mwachangu ndikuyesa mayeso onse ofunikira omwe akuwonetsa kuchuluka kwa lactate, pyruvate ndi kuchuluka kwake m'magazi.

Pochotsa Metformin mwachangu mthupi, ndibwino kugwiritsa ntchito hemodialysis.

Metformin pa mimba ndi mkaka wa m`mawere

Pa nthawi yoyembekezera, Metformin imatsutsana kwambiri. Itha ndipo iyenera kumwedwa asanatenge pakati azimayi omwe ali ndi matenda amtundu wa 2 komanso kunenepa kwambiri kuti achulukitse chiopsezo chotenga pakati komanso kuwonda, koma mankhwalawo amayenera kusiyidwa pakakhala pakati. Madokotala ambiri amapereka Metformin panthawi yoyamba trimester, koma izi zimakhala ndi zovuta za mwana wosabadwayo.

Pambuyo pake, ana omwe amayi awo adatenga Metformin panthawi yoyembekezera amakhala pachiwopsezo chotenga kunenepa kwambiri ndi matenda a shuga. Chifukwa chake, zimatsimikiziridwa kuti mayi ayenera kutenga Metformin panthawi yokhayo pokhapokha pakufunika komanso kusowa kwina kwa mankhwala ena.

Pokonzekera kukhala ndi pakati, Metformin adalandira ulemu wokhala "wofunikira" pakati pa azimayi omwe ali ndi shuga, onenepa kwambiri komanso ovomereza. Amayi onenepa kwambiri amatha kuvutika ndi kubereka. Metformin imathandizira thupi kugawa glucose ndikuchepetsa kuchuluka kwamafuta acid, mwakutero imakhazikitsa chiyambi cha mahomoni ndikubwezeretsanso kwina kwa masiku.

Mukamayamwa, ndikofunikira kuyimitsa kugwiritsa ntchito Metformin.

Metformin ya ana

M'zaka za m'ma 1900, matenda ashuga amtundu wa II mwa ana ndi achinyamata adayamba kuchuluka. Komanso, matendawa samapitirira ana amitundu ndi magulu osiyanasiyana. Ana padziko lonse lapansi amakonda kunenepa kwambiri ndipo amachepetsa mphamvu ya minofu ku insulin. Posachedwa, mapulogalamu ambiri apangidwa kuti asamachiritse ana mankhwala omwe ali ndi matenda osokoneza bongo a insulin, omwe amaphatikizapo kudya moyenera komanso kuchita masewera olimbitsa thupi. Komabe, ochulukirapo akuyenera kugwiritsa ntchito mankhwalawa. Moyo wosachita zambiri komanso kudya mopanda thanzi wokhala ndi shuga komanso mafuta ambiri zidapangitsa kuti matendawo apezenso mphamvu.

Metformin poyamba adalakwika mwa ana osakwana zaka 15. Pambuyo pa kafukufuku waposachedwa ndi madokotala aku America, momwe ana ndi achinyamata azaka zapakati pa 10-16 adatenga Metformin kwa masabata 16, kuchepa kwakukulu kwa kuchuluka kwamafuta am'magazi m'magazi, kuchepa kwa milingo yaopoproteins otsika kwambiri komanso otsika kwambiri, komanso triglycerides, ndi kuwonda. Zina mwazotsatira zoyipa, kapena hypoglycemia kapena lactic acidosis sizinawoneke, zochitika zosowa mwanjira ya mseru kapena kutsegula m'mimba sizinakhudze zotsatira za phunziroli.

Ubwino wogwiritsa ntchito Metformin muubwana watsimikiziridwa, kuyambira zaka 10 popanda zovuta zazikulu, koma ndi zotsatira zabwino komanso mtsogolomo kuti mutsirize kuyang'anira matenda ashuga ndikuchepetsa mlingo wocheperako ndi kuthekera kwa kuimitsidwa kwake.

Metformin ndi Vitamini B12

Vitamit B12 kapena cyanocobalomin ndi chinthu chofunikira pa hematopoiesis ndi magwiridwe amanjenje; chifukwa chake, mapuloteni amapangidwa m'thupi.

Amaganiza kuti kugwiritsa ntchito Metformin kwa nthawi yayitali, mankhwalawa amasokoneza mayamwidwe mu ileamu ya vitaminiyi, yomwe imapangitsa kutsika pang'ono m'magazi. Mchaka chachisanu chovomerezedwa, mulingo wa B12 umatsika ndi 5% pachaka cha 13 - ndi 9.3%.

Tiyenera kudziwa kuti kuchepa kwa 9% sikumatsogolera ku hypovitaminosis komanso kukula kwa hemolytic anemia, koma kumawonjezera chiopsezo chamtsogolo.

Kusowa kwa B12 kumapangitsa kuti magazi azikhala ndi hemolytic anemia, zomwe zikutanthauza kuti maselo ofiira am'magazi amakhala osalimba ndikukangana mkatikati mwa magazi. Izi zimabweretsa kukula kwa magazi m'thupi komanso jaundice. Khungu ndi mucous zimagwira mtundu wachikasu, wodwalayo amadandaula chifukwa cha kufooka, pakamwa pouma, dzanzi la miyendo ndi mikono, chizungulire, kusowa chilimbikitso, kusayenda bwino.

Kuti mudziwe kuchuluka kwa vitamini B12, muyenera kuyezetsa magazi kuti muwone mawonekedwe ndi kukula kwa maselo ofiira amwazi. Ndi B12 akusowa hemolytic anemia, maselo ofiira am'magazi amakhala okulirapo kuposa momwe amakhalira ndi nyukiliya, kuchepa kwa magazi kumawonetsedwa, ndipo bilirubin yopanda malire idzachulukitsidwa pakuwunika kwa magazi.

Ndikofunikira kupanga chifukwa chosowa vitamini B12 mukamatenga Metformin. Dokotala wanu angakupatseni mankhwala othandizira ndi mavitamini.

Kuchitika moseketsa komanso komveka, koma chithandizo cha kuchepa kwa B12 kumene kumachitika kumapangidwanso ndikupereka vitamini, kokha m'mitsempha.

Malo osungira

Metformin iyenera kusungidwa m'malo owuma, amdima, kutentha kwa madigiri 15-25. Ndi yosungirako bwino, moyo wa alumali ndi pafupifupi zaka zitatu.
Pewani kufikira ana. Ndiwophatikizika kuti atenge tsiku lotha ntchito.

Glucophage ndiye mndandanda woyamba wa Metformin wotulutsidwa ku USA.

Mwa zina, ambiri ali ndi zabwino. Njira yosavuta yogwiritsira ntchito, zovuta zochepa ndizomwe zimakopa kwambiri ogula. Kufunika kwakumwa kwa mankhwalawa panthawi yomwe muli ndi pakati ndizovuta zina. Odwala ambiri omwe ali ndi matenda ashuga a 2, polycystic ovary, prediabetes amasiya ndemanga zambiri zokhuza mankhwala.

Ndizopindulitsa kwambiri komanso zotsika mtengo kugula mankhwalawa kwa miyezi ingapo, mutha kumwa pamtengo wabwino kwambiri ngati mungagule mapaketi angapo nthawi imodzi. Ndipo izi ndizotheka, chifukwa dotolo wabanja amawunika kuchuluka kwa chithandizo cha Metformin kamodzi theka la chaka, osati kangapo.

Onani malingaliro enieni angapo:

Mayi anga ali ndi matenda ashuga, motero ndikudziwa kuti ndiyenera kuyang'anira kuchuluka kwa shuga. Nditapanikizika kwambiri kuntchito, ndidayamba kumva kuwawa, ndimangokhalira kugona, ndipo ndidapita kwa adotolo. Zidapezeka kuti kuchuluka kwa shuga ndikokwezeka ndipo adotolo adandiyikira Metformin, ndipo adandiwuzanso kuti ndizichita masewera olimbitsa thupi pang'ono komanso kudya zakudya.
Anayamba kutenga kawiri patsiku mamiligalamu 500 a Metformin. Malangizo ogwiritsira ntchito mafotokozedwe oyipa ndipo poyamba panali m'mimba ndikumva kuwawa m'mimba. Komabe, patatha masiku angapo mutatenga nthawi zosasangalatsazi kudutsa. Ndikufuna kudya pang'ono ndikamamwa mankhwalawa. Masabata angapo atadyeka, anayamba kumva bwino. Kenako adadutsa mayeso a shuga ndipo nawonso, anali abwinobwino. Metformin anandithandiza. Malangizowo akuonetsa kuti amwe kokha ngati adokotala akuwuza, choncho musamwe nokha.

Pambuyo pa zaka 30, adayamba kunenepa pang'onopang'ono, adayesa njira zingapo modekha kuti ataye, koma kwenikweni sizinapeze chifukwa. Ndidapeza pa intaneti kuti mutha kugwiritsa ntchito Metformin kuti muchepetse kunenepa. Malangizo ogwiritsira ntchito samalimbikitsa kuti ndikhale ndi mankhwalawa kwa anthu athanzi, koma ndidaganiza zokhala ndi mwayi. Anamugwira mwezi, munthawi yomweyo adaponya mapaundi 7. Metformin imachepetsa kwambiri njala. Kupatula pa zakudya, zotsekemera ndi ufa. Ndine wokhutira ndi zomwe zachitika, mpaka pano sindikulemera.

Zaka zinayi zapitazo, adotolo adapeza polycystic ovary syndrome. Ndine wokwatiwa ndipo panthawiyi sindinathe kutenga pakati. Panali mavuto osaneneka ndi kuzungulira, ndinayesa mankhwala osiyanasiyana, koma palibe chomwe chinathandiza. Nditayang'ananso pa intaneti pa umodzi mwamalo omwe ndinawona momwe Metformin adalangizidwira pankhaniyi. Malangizo ogwiritsidwira ntchito amagawa mankhwalawa ngati antidiabetes, koma ndidawerenga kuti polycystosis imathandizidwanso koyesera ndipo zotsatira zake ndizolimbikitsa. Ndinaganiza zoyesera.

Ndinkamwa pafupipafupi, koma chonsecho ndinamwa kwa miyezi ingapo, poyamba panali zotsatira zoyipa, koma zidatha. Ndipo pakuwunika kotsatira, adotolo adati pali zizindikiro za kutenga pakati. Sindinakhulupirire makutu anga! Ndinapita ndikukapereka magazi - ndipo zowonadi, posachedwa ine ndikhala mayi!

Ngakhale ndimamwa mankhwala ena, ndikuganiza kuti Metformin yandithandiza!

Ku Russia, mtengo wamankhwala umasiyanasiyana kuchokera ku ruble 100-220 pa chithunthu chilichonse. Tiyeni tiwone mitengo yake mwatsatanetsatane:

Mapiritsi a Metformin 500 mg, 60 ma PC. (wopanga Gedeon Richter) - ma ruble 95,
Mapiritsi a Metformin 500 mg, 60 ma PC. (wopanga Canonfarm, Russia) - ma ruble 165,
Mapiritsi a Metformin-Teva 1000 mg, 30 ma PC. (Wopanga Teva, Israeli) - ma ruble 200,
Metformin Richter mapiritsi 500 mg, 60 ma PC. (Wopanga Gideon Richter, Hungary) - 215 ma ruble.

Mitengo ku Ukraine kuchokera pa 22 mpaka 380 hryvnia. Tiyeni tiwone mitengo yake mwatsatanetsatane:

Mapiritsi a Metformin 500 mg, 30 ma PC. (opanga Indar Ukraine) - 25 h Htnias,
Mapiritsi a Metformin 500 mg, 60 ma PC. (opanga Indar Ukraine) - 45 h pantnias,
Metformin Sandoz mapiritsi 500 mg, 120 ma PC. (Wopanga LEK S.A., Poland) - 280 hhucnias,
Metformin Astrapharm mapiritsi 500 mg, 60 ma PC. - 45 hryvnia.

Metformin ndi mankhwala omwe amaphunziridwa bwino omwe amagwiritsidwa ntchito m'magawo ambiri, omwe adapangidwa kumapeto kwa zaka za zana lomaliza, ndipo akadali ovomerezeka. Zokhudza kagayidwe kazakudwala kamasintha kagayidwe kachakudya ka minyewa, kumalepheretsa kukula kwa mtima wamavuto, zomwe zikutanthauza kuti ndi njira yabwino kwambiri yopeweretsera matenda osokoneza bongo, ischemic ndi hemorrhagic stroke, diabetic angiopathy, neuropathy ndi nephropathy. Pogwiritsa ntchito Metformin, mulingo komanso moyo wa anthu odwala matenda ashuga wakula. Kafukufuku watsopano amachitika chaka ndi chaka ndipo njira zambiri zamankhwala zimawululidwa, pomwe zinali ndi malangizo angapo, lero zikuwoneka kuti zikuyendera limodzi ndi dziko lonse lapansi.

Ndemanga za Metformin 850

Chochitacho chimalekeredwa bwino. Odwala omwe amatsata malangizowo ndipo amawonedwa ndi dokotala amasiya ndemanga zabwino. Pamaso pa contraindication, mankhwalawa nthawi zambiri amatengedwa, koma kuwunika koyipa kumatsalira chifukwa cha kuwonongeka.

Yuri Gnatenko, endocrinologist, wazaka 45, Vologda

Yogwira pophika imachulukitsa kagayidwe kazinthu, imalimbikitsa kugwiritsidwa ntchito kwa shuga ndikuwonjezera chidwi cha thupi ku insulin. Kuphatikiza apo, muyenera kuchepetsa kuchuluka kwa chakudya chamafuta ochepa komanso kudya mafuta ambiri. Kutsatira mlingo woyenera komanso moyo wokangalika, zidzathandiza kupewa zovuta monga matenda a mtima.

Maria Rusanova, wothandizira, wazaka 38, Izhevsk

Chidacho chili ndi mphamvu yopulumutsa insulin. Mankhwala amathandiza kuchepetsa kunenepa, kusintha glycemic control. Poyerekeza ndi kutenga, kuchuluka kwa maukadaulo amadzi am'magazi, glycated hemoglobin, kumachepa. Pofuna kupewa zovuta kuchokera m'matumbo am'mimba, muyenera kuwonjezera nthawi 1 mu masabata awiri ngati kuli kotheka.

Elizabeth, wazaka 33, Samara

Mankhwala othandiza kuchepetsa shuga. Amatumizidwa piritsi limodzi kawiri pa tsiku. Mlingo unali wokwanira kutsitsa shuga. Zotsatira zoyipa zimaphatikizapo chizungulire, mapando otayirira, nseru ndi kutulutsa. Ndinayamba kumwa mankhwalawo ndi chakudya ndipo zizindikirizo zinazimiririka. Ndikupangira kumwa motengera malangizo.

Diana, wazaka 29, Suzdal

Atalembedwa ndi endocrinologist, adayamba kumwa mapiritsi. Mankhwalawa anathandizira kuchepetsa thupi, kuchepetsa matenda a shuga ndi mafuta m'thupi. Metformin adalimbana ndi ntchitoyi popanda mavuto. Kwa miyezi itatu ndinataya 7 kg. Ndikukonzekera kuzitengera patsogolo.

Kuchita mankhwala osokoneza bongo

Pali kuwonjezeka kwa zotsatira za hypoglycemic panthawi imodzi:

Β-blockers
NWPS
Kukonzekera kochokera ku sulfonylurea zotumphukira, zonenepa
ACE zoletsa ndi Mao
Acarbose
Cyclophosphamide
Oxytetracycline
Insulin.

Kutsika kwa hypoglycemic zotsatira kulembedwa panthawi yomwe mukugwiritsa ntchito mankhwalawa:

COC
Sympathomimetics
Mahomoni a chithokomiro
GKS
Amachokera ku phenothiazine komanso nicotinic acid
Epinephrine
Ma diuretics ena ("loop" ndi magulu a thiazide)
Glucagon.

Cimetidine amatha kuletsa kuchotsedwa kwa metformin, komwe kumawonjezera chiopsezo cha lactic acidosis.

Pogwiritsa ntchito munthawi yomweyo ma anticoagulants, mphamvu ya mankhwala ozikidwa pa metformin itha kufooka.

Kumwa mankhwala osokoneza bongo omwe ali ndi ethanol kumatha kuyambitsa lactic acidosis.

Zotsatira zoyipa ndi bongo

Kukula kwamayesero am'mbali:

M`mimba thirakiti: nseru ndi kusanza, kutchulidwa wachitsulo pakamwa, kusowa kudya, kudzimbidwa, kupweteka kwa epigastric
Metabolism: ntchito kwa nthawi yayitali - B12 hypovitaminosis, kawirikawiri - chitukuko cha lactic acidosis
Hematopoietic dongosolo: kupezeka kwa megaloblastic mtundu magazi
Endocrine dongosolo: mawonekedwe a hypoglycemia
Khungu: zotupa, matupi awo sagwirizana.

Mankhwala osokoneza bongo samaphatikizidwa ndi munthawi yomweyo kugwiritsa ntchito mankhwala osokoneza bongo ochokera ku sulfonylurea, Mowa ndi insulin. Imadziwoneka ngati ululu wam'mimba, kutsekula m'mimba, mseru, kupuma movutikira, komanso zizindikiro zina za lactic acidosis. Chithandizo chowonjezera chikuwonetsedwa momwe njira zimatengedwa kuti muchepetse kuchepa kwa madzi ndi kusintha kagayidwe.

Mtengo kuyambira 87 mpaka 545 rubles.

Gliformin ndi mankhwala omwe ali m'gulu la mankhwala a Biguanide, omwe amadziwika ndi hypoglycemic effect. Zomwe zimagwiritsidwa ntchito ndi metformin. Mankhwalawa amathandizira kuchepa kwa glucose m'mimba, zomwe zimapangitsa kuti chiwopsezo cha minofu chiwonjezeke. Fomu lotulutsidwa la Gliformin - mapiritsi.

Ubwino:

Zimathandizira kuchepetsa thupi
Itha kuperekedwa limodzi ndi insulin
Kugwiritsa ntchito nthawi yayitali kumaloledwa.

Chuma:

Contraindicated pa mimba ndi mkaka wa m`mawere
N`kutheka zimachitika za kuphwanya kwa m'mimba thirakiti
Zitha kupangitsa kuti matupi awo azigundana.

Zomwe zimathandiza Metformin. Malangizo ogwiritsira ntchito

Gulu: m Meyi 7, 2017 ·: 3 · Kuwerenga: 5 min · Views:

Mankhwala amakono a antiidiabetes omwe amalimbikitsa kuyamwa kwa glucose m'magazi - mapiritsi a Metformin. Kodi mankhwalawa amathandizira chiyani? Malangizo ogwiritsira ntchito akuwonetsa kuti mankhwalawa adadzitsimikizira pokhapokha ngati mukudwala matenda amtundu wa 2.

Kodi mawonekedwe ake ndi otani?

Wopanga mawonekedwe a mankhwalawo "Metformin" akuwonetsa wopanga kwambiri - Dimethyl Biguadine. Ndiye amene amabadwa mwa njira yokwaniritsa kuyamwa kwa glucose ndi minofu.

Mwa zina zothandizira ndi zomwe zalembedwa - wowuma ndi mania stearate, komanso talc. Cholinga chawo chachikulu ndikusunga ndikuwonjezera zotsatira za chinthu chachikulu chogwira ntchito.

Anapereka zotsatira zamankhwala

Woimira chidwi pagulu la Biguanide ndi mankhwala antidiabetesic Metformin. Malangizo ogwiritsira ntchito (mtengo, ndemanga, malingaliro a mankhwala omwe takambiranawa afotokozedwera m'nkhani ili m'munsiyi) akufotokoza kuti kumwa mankhwalawa kumathandizira kuti pakhale shuga wambiri mu chiwindi. Poyerekeza izi, hyperglycemia yomwe ilipo imachepa m'magazi.

Kuphatikiza apo, chidachi chimapereka chiwonjezeko chabwino kwambiri pakumverera kwa insulin receptors, kumathandizira kuyamwa kwa hormone insulin ndi oxidation yamafuta acids, omwe amathandizira kuwonjezera kuphatikizika kwa glucose. Kuphatikiza apo, kuchepa kwa mayamwidwe ake m'mimba kupatsidwa chakudya.

Mankhwala "Metformin" m'njira yabwino kwambiri amachepetsa kuchuluka kwa timadzi timene timalimbitsa magazi mu seramu yamagazi, komanso kuchuluka kwa kuchuluka kwa mafuta m'thupi komanso kuchepa kwa lipoproteins. Kuphatikiza apo, kusintha kwa zamatumbo m'matumbo kumapetsedwa. Zotsatira zina za pharmacological ziyenera kuwonetsa:

kubwezeretsa kwa magazi,
kusintha kwa magazi a magazi
kuchepa kwamphamvu kwa thrombosis.

Mankhwala amapereka kukonza magawo pamaso pa kunenepa kwambiri mwa munthu.

Mapiritsi a Metformin: zomwe mankhwalawo amathandizira nawo komanso ngati apatsidwa

Malangizo a mankhwalawa alembe zotsatirazi mikhalidwe yoipa yomwe mankhwalawo adadzitsimikizira kuchokera ku mbali yabwino:

matenda ashuga - amtundu woyamba kapena wachiwiri,
mankhwala othandizira pachithandizo chachikulu ndi insulin kapena mankhwala ena a shuga,
shuga monotherapy.

Kuphatikiza apo, mankhwalawa amatha kuikidwa ndi katswiri kwa munthu yemwe ali ndi vuto la kunenepa kwambiri, ngati pakufunika kuwongolera magawo a glucose m'magazi, ndipo ndizosatheka kukwaniritsa chinthu choterocho pokhapokha ngati mukudya komanso kuchita masewera olimbitsa thupi.

N`zotheka kugwiritsa ntchito mankhwalawa polimbana ndi mazira a polycystic - komabe, kuyang'aniridwa kwapadera kwa akatswiri, kuyang'anira mwamphamvu magwiridwe a shuga ndikofunikira.

Mankhwala "Metformin": malangizo ogwiritsira ntchito Mlingo

Malangizo omwe amaphatikizidwa ndi phukusi ndi mankhwalawa akuwonetsa kuti mapiritsiwo adapangira pakamwa. Simufunikanso kuwaphwanya, kupera, kutafuna. Ndikokwanira kumeza piritsi limodzi, limodzi ndi madzi okwanira, makamaka mukatha kudya.

Ngati kumwa mapiritsi ndikovuta chifukwa cha kukula kwake, ndizovomerezeka kugawa magawo awiri, omwe amamezedwa chimodzi pambuyo pa chinthu chimodzi.

Poyambirira, mlingo woyenera wa mankhwalawa ndi 1000 mg / tsiku, koma kuti mupewe mavuto, uyenera kugawidwa pakati Mlingo wa 2-3.

Ndiye kuti pang'onopang'ono mlingo umawonjezeka - ndi gawo la masiku 10-14 ndikuwunika thanzi la wodwalayo, magawo a glycemic. Mlingo wololedwa wambiri patsiku ndi 3000 mg.

Munthawi ya mankhwala ndi Metacinator wothandizila "Metformin" wa okalamba, tikulimbikitsidwa kuwunika ntchito za impso. The achire achire ntchito za mankhwala zimatheka pambuyo 10-14 masiku kuyambira chiyambi cha mankhwala.

Ngati munthu wadwala kale mankhwala aliwonse osokoneza bongo, poyamba maphunzirowo amaletsedwa, kenako chithandizo chamankhwala cha Metformin chimayamba mu mulingo wovomerezeka ndi katswiri.

Ngati ndi kotheka, kumwa mankhwalawa kumatha kuphatikizidwa ndi insulin, m'masiku ochepa mlingo wa insulin sukusintha. Koma kenako imatsitsidwa pang'onopang'ono - moyang'aniridwa ndi dokotala.

Mtheradi ndi zotsutsana pachibale

Monga othandizira ena a pharmacological, mankhwalawa a Metformin ali ndi mndandanda wawo wokhudzana ndi zotsutsana kwathunthu. Malangizo ake ndi awa:

lactic acidosis wopangidwa, kapena kupezeka kwake mu anamnesis,
dziko loyipa
Hyperreaction payekha yogwira kapena yothandizira ya kukonzekera kwa Metformin, komwe mapiritsiwo angayambitse zotsatira zoyipa.
cholakwika mu ntchito ya aimpso, kapena zomwe zimachitika mwanjira ya kwamikodzo, yomwe ingayambitse vuto lofananalo,
kuperewera kwa adrenal,
hepatic kubwezeretsa,
Matenda a matenda ashuga
zovuta zina zonse zomwe zimadzetsa kuchepa thupi kwa thupi, mwachitsanzo, kusanza, kutsekula m'mimba, komanso hypoxia - kugwedezeka, kulephera kwa mtima,
uchidakwa.

Akatswiri amagogomezera kuti ngakhale kugwiritsidwa ntchito kamodzi kwa zinthu zopangidwa ndi mowa ndi mapiritsi a Metformin kumatha kubweretsa kuphwanya kwakukulu mu metabolic system.

Kuphatikiza apo, kumwa mankhwalawa ndiwotsutsana:

ndi matenda osiyanasiyana pachimake nyengo,
malungo
matenda oyambitsidwa mu gawo lawo lowerengera,
kuchitapo kanthu kwakukulu, komanso nthawi yoyambitsanso.
mphindi ya intrauterine kukula kwa mwana, mkaka wake wotsatira.

Mosamala, mankhwalawa "Metformin" angalimbikitsidwe pochiza matenda ashuga kapena mawonekedwe ake achinyamata. Komabe, pankhaniyi, kuwunika kwa adokotala kuyenera kuchitika. Ndi kutsatira glycemic magawo, aimpso ntchito.

Zosafunika

Mwambiri, mankhwalawa amaloledwa ndi anthu. Zotsatira zosafunikira izi sizingachitike kawirikawiri:

vuto la dyspeptic - kufuna kusanza, kapena kusanza,
hypovitaminosis B12,
kuchepa kwamtima
kulimbirana mwachangu, kutsekula m'mimba,
gastralgia,
lactic acidosis yofuna kutha kwa mankhwala,
kulawa kwazitsulo mkamwa
megablastic anemia,
Kuphulika kwa zamatenda.

Pambuyo pakutha kwa mapiritsi a Metformin, zotsatira zoyipa zimatha. Katswiri amasankha njira zina zochizira.

Mndandanda wa mankhwala "Metformin"

Mapangidwe ofananawo ali ndi fanizo:

Metformin Richter.
"Metformin hydrochloride."
Nova Met.
"Metformin Sandoz."
NovoFormin.
"Metfogamma 850."
Siofor 500
"Metadiene."
Glformin.
Siofor 1000
Metformin Richter.
Glucophage.
Bagomet.
Siofor 850
"Metfogamma 500."
"Metformin Canon."
Gliminfor.
"Forethine."
"Metformin Teva."
"Langerine."
Glycon.
Glucophage Kutalika.
"Metfogamma 1000."
"Metformin."
"Metospanin."
Sofamet.
"Fomu Pliva."

Mapiritsi a Metformin ku Moscow atha kugulika ma ruble 92 - 284. Mtengo ku Kazakhstan ndi 1190 tenge. Ku Minsk, malo ogulitsa mankhwala amapereka analogue of "Metformin farmland" kwa ma 3-6 bel. ma ruble. Ku Kiev, mankhwalawa amagulitsidwa m'masitolo a 100 - 300 hryvnia.

Ndemanga zambiri zabwino zomwe anthu adasiya pazomwe zimakambirana za mankhwala othandizira odwala matenda ashuga zikuwonetsa kukayikira kosakayikira kwa mankhwala a Metformin.

Malangizo ogwiritsira ntchito ndi kuwunika kwa madokotala amatsimikizira kuti mankhwalawa amakupatsani mwayi wowongolera magawo a hyperglycemia.

Odwala ena amamwa mapiritsi a Metformin zakudya, omwe akatswiri sawalimbikitsa.

Momwe mungatenge metformin kuti muchepetse thupi ndipo ndiyofunika konse

Tsiku labwino! Pofunafuna chithunzi chokongola chomwe azimayi okha samayesa, ngakhale atakhala kuti njira imeneyi ndi yogwira mtima kapenanso yovulaza thanzi.

Ndipo lero tikulankhula za metformin (Richter, Teva, ndi zina), momwe mungatengere molondola mukamachepetsa thupi, perekani malangizo ogwiritsa ntchito, komanso ndemanga yanu monga dokotala yemwe akugwira ntchito ndi mankhwalawa nthawi zonse.

Ndikukhulupirira kuti mutawerenga nkhaniyi mutha kukhala ndi chithunzi chonse cha mankhwalawo ndipo mutha kuganiza zaka zana ngati mufunika kuzigwiritsa ntchito polimbana ndi kunenepa kwambiri.

Metformin: malangizo ogwiritsira ntchito kuchepa thupi

Poyamba, Metformin poyambirira adapangidwa kuti azithandiza odwala omwe ali ndi matenda a shuga mellitus. Pambuyo pake, pophunzira za mankhwalawa, zisonyezo zina zidawululidwa, mwachitsanzo, chithandizo cha kunenepa kwambiri komanso kunenepa kwambiri. Koma kodi ndiwothandiza kwa anthu onenepa kwambiri opanda matenda ashuga? Kuti tichite izi, tiyenera kumvetsetsa momwe mankhwalawa amagwirira ntchito komanso chifukwa chake kunenepa kwambiri kumachitika.

Ngati mukufuna kuphunzira mokwanira machitidwe onse a metformin, ndikupangira kuti muwerenge kaye nkhani yowunika "Metformin: momwe imagwirira ntchito." Munkhaniyi sindiyankhula za zonse zomwe zilipo, koma ndingolankhula zokhudzana ndi kuchepa thupi.

Chifukwa cha zomwe metformin "imathandizira" kuchepa thupi

Ndinganene motsimikiza 99% kuti pafupifupi anthu onse onenepa kwambiri amakhala ndi vuto la kusamva bwino kwa insulin pakapita nthawi.

Insulin ndi timadzi tating'onoting'ono tokhala ndi glucose m'maselo. Pazifukwa zina, maselo samalowanso insulin ndipo glucose sangathe kulowa m'maselo.

Zotsatira zake, ziphuphu zimapatsidwa chizindikiro kuti ziwonjezere kupanga kwa insulin ndipo zimayamba kulowa m'magazi.

Izi zimapangitsa kuti mafuta asamale kwambiri, chifukwa kusungidwa kwamafuta kumakhala kosavuta komanso mwachangu.

Zomwe zimapangitsa kuti maselo asiye kumva kuti ali ndi insulin yambiri, koma ochulukirapo amakhala ndi mafuta ochulukirapo.

Maselo amadzaza ndi shuga ndipo amayesa kuzimitsa osazindikira insulin. Zinafika poti insulini nthawi zambiri sili ndi mlandu uliwonse, chifukwa adangochita ntchito yake.

Zotsatira zake, zimachulukirachulukira, ndipo zimayamba kuchuluka, zimadana kwambiri ndi maselo amthupi. Likukhalira kuzungulira koyipa komwe kumabweretsa kunenepa kwambiri, kukana insulini ndi hyperinsulinism.

Metformin imakhudzana ndi zotumphukira za insulin, ndikuchepetsa ndikubwerera mulingo wake wachilengedwe. Izi zimabweretsa kuyamwa kwabwinobwino kwa glucose ndi maselo ndipo sikulola kuti insulini ipangidwe mwambiri, zomwe zimatanthawuza kusunga mafuta.

Mwachidule, metformin imagwira ntchito pochita zina mwa insulin pochotsa insulin. Kuphatikiza apo, metformin imakhala yofooka yothandizanso - kuchepetsa kulakalaka (anorexigenic athari). Ndi zomwe aliyense amaganiza za iye akayamba kumwa mankhwalawo.

Komabe, izi ndizofooka kwambiri kotero kuti sizimamvekanso ndi aliyense. Chifukwa chake dalirani izi, kutali kwambiri, zotsatira za mankhwalawo sizoyenera.

Kodi ikhoza kuchepetsa kulemera ndi metformin: kuwerengetsa kwa dotolo

Ngakhale kutsitsa shuga kochepa, chifukwa chakuti kumalimbikitsa kuyamwa kwa shuga ndi maselo, metformin sikuti nthawi zonse imabweretsa kuwonda. Ndinganene kuti izi ndizosowa kwambiri ndipo sizifotokozedwa.

Ngati mukuganiza kuti kumwa mapiritsi awiri patsiku, koma osachita zina zilizonse kuti muchepetse kunenepa, mumataya mafuta 30 makilogalamu, ndiye ndiyenera kukukhumudwitsani. Metformin ilibe katundu. Zabwino kwambiri pamenepa mungotaya mapaundi ochepa.

Ndipo momwe mungatengere metformin kuti muchepetse kunenepa

Kumbukirani kuti metformin sindiwo mapiritsi amatsenga omwe amathetsa ma kilogalamu anu mozizwitsa, ndipo pakadali pano mukudya mkate wachikhumi womwe uli pa sofa. Ndi njirayi, palibe chida chomwe chidzagwira ntchito. Kusintha kofananirako kwa moyo wanu, komwe kumaphatikizapo zakudya, kuyenda ndi malingaliro, zomwe zimatha kubweretsa zotsatira zenizeni.

Titha kunena kuti moyo watsopano ndi wofunikira kwambiri, ndipo metformin imangothandiza. Mankhwalawa siwopanda ndipo nthawi zambiri mungathe kuchita popanda iwo. Izi sizikugwira ntchito pazomwe zimalemera kwambiri komanso shuga. Koma ngati mumangokhala ndi kunenepa kwambiri komanso popanda matenda a shuga, zimakhala bwino m'maganizo kuti muchepetse thupi mwa kumeza mapiritsi, ndiye kuti muchite bwino.

Ndi metformin iti kuti musankhe? Metformin Richter kapena Metformin Teva, ndipo mwina Metformin Canon

Pakadali pano, pamsika wamankhwala pali makampani ambiri omwe amapanga mapiritsi otere. Mwachilengedwe, kampani iliyonse imatulutsa metformin pansi pa dzina la malonda, koma nthawi zina amatchedwanso "Metformin", mathero amangowonjezeredwa omwe amawonetsa dzina la kampaniyo. Mwachitsanzo, metformin-teva, metformin-canon kapena metformin-richter.

Palibe kusiyana kwakukulu mu mankhwalawa, chifukwa chake mutha kusankha iliyonse. Ndingonena kuti ngakhale pali zinthu zomwezo, zina zowonjezera zingakhale zosiyanasiyana ndipo pazomwe zimachitika zimatha kuwonedwa, ngakhale metformin imakhalanso ndi zovuta. Werengani nkhani yomwe ndidalimbikitsa pamwambapa.

Momwe mungamwe metformin kuti muchepetse thupi

Muyenera kuyamba ndi mlingo wa 500 mg kamodzi. Mankhwalawa ali ndi mitundu yosiyanasiyana - 500.850 ndi 1000 mg. Ngati mukufuna kuyamba ndi mlingo waukulu, mudzamva kukongola konse kwamatenda oyipa, omwe amakhala makamaka amisala osokoneza bongo kapena, ku Russia, matenda am'mimba. Onjezani mlingo pang'onopang'ono ndi 500 mg pa sabata.

Mlingo wambiri watsiku ndi tsiku umatha kukhala 3,000 mg, koma monga lamulo, madokotala ndi ine pakati pawo ali ndi malire a 2000 mg.Kupitilira kuchuluka kumeneku, kugwirako ntchito kumakhala kochepa, ndipo mavuto ake akuwonjezeka.

Mankhwala amatengedwa nthawi ya chakudya kapena itatha. Amalembedweratu asanagone - mankhwalawa amakhalanso olondola ndipo ali ndi malo oti akhale. Zotsatira zoyipa zikaoneka ndipo sizinadutse pambuyo pa masabata awiri kuyambira pomwe munayambira, ndiye kuti mankhwalawa siabwino kwa inu ndipo ayenera kusiyidwa.

Metformin: kuwunika kwa kunenepa

Sindinali waulesi kwambiri ndipo ndinakwera pamagulu ndi malo omwe kulumikizana pakati pa kuchepetsa thupi ndi komwe amagawana zomwe akumana nazo. Pempholi lidatulutsa mphamvu ya metformin.

Ndikukupatsirani ndemanga zenizeni za anthu kuti musawafunse pamaneti. Ndemanga zambiri sizabwino. Zomwe zimakhala zabwino nthawi zambiri zimalimbikitsa mtundu wina wa mankhwala kapena kugwiritsa ntchito njira zina kupatula metformin.

Ine sindinalamulire ndemanga; zitha kukhala ndi zolakwika zosiyanasiyana.

Unikani Na. 1 (pakutsimikizira mawu anga)

Mverani, ngati mumatsatira malangizo olimbitsa thupi mu metformin .. ndiye kuti metformin palokha siyofunika)))))))))))

Unikani Na. 2 (osati onse odwala matenda ashuga)

Mayi anga, omwe ali ndi matenda ashuga, amamwa metformin. Ndipo china chake sachepa naye. = -))))))))) Chinyengo china.

Unikani Na. 3 (zotsatira z zero ndi zotsatiranso, chinthu chachikulu ndikubweretsa mawu)

Ndinaganiza z kumwa Metformin kuti muchepetse thupi, chifukwa amati imaletsa chakudya. Ndinkamwa mogwirizana ndi malangizo, pang'onopang'ono ndikuwonjezera muyezo. Ndiyenera kunena nthawi yomweyo kuti sindimadwala matenda ashuga kapena matenda aliwonse kuti ndizinena motsimikiza.

Ndipo, zoona zake, sindinazindikire zotsatira pambuyo pa mwezi umodzi. Winalemba kuti ali ndi zovuta zake, kuti mutha kudwala ngati mumamwa osapangana naye. Chilichonse chinali bwino ndi ine, kapena m'malo mwake, mwanjira iliyonse - kuti ndinamwa zomwe sindinachite. Mwina ndibwino ngati mankhwala, koma kuchepa thupi - 0.

Chifukwa chake sindinganene motsimikiza kuti ndimalimbikitsa kapena ayi. Koma pofuna kuchepetsa thupi, ayi.

Unikani Na. 4 (zidakumana ndi zovuta)

Inemwini, njirayi sinagwirizane ndi ine, zovuta zanga zamatumbo zimakhudzidwa, ndipo ngakhale nseru sizinayende ngakhale mlingo utachepa, ndinasokoneza maphunziro. Palibenso kuyesera.

Unikani Na. 5 (sagwira ntchito popanda chakudya)

Ndinkamwa molingana ndi zidziwitso zachipatala ndipo sindinachepetse thupi popanda kudya. ndi zakudya, inde, ndachepa, koma glucophage alibe chochita ndi izo

Chifukwa chake, ndikuganiza kuti aliyense adamvetsetsa kuti kukonzekera kwa metformin si piritsi labwino kapena zakudya zowonjezera zatsopano, osati owotchera mafuta, osati othandizira mafuta m'matumbo, koma mankhwala akulu omwe ali ndi zisonyezo zachindunji.

Ndipo lingaliro lalikulu lomwe ndimafuna kuti ndikufotokozereni kuti metformin sithandiza popanda kusintha kadyedwe, koma monga mankhwala ena kuthana ndi kunenepa kwambiri.

Ndi metformin komanso moyo watsopano, kuchepa thupi kumakhala kosangalatsa, m'njira zina kumakhala kosavuta.

Ndipo popeza pali mwayi wopeza zotsatira popanda mankhwala, ndiye kuti simukuyenera kuyamba kumwa metformin nthawi yomweyo? Chemistry yochepa imatanthawuza thanzi! Ndizo zonse. Amvera kulandira zolemba zatsopano ndi maimelo ndikudina mabatani azama media pansipa.

Ndi chisangalalo ndi chisamaliro, endocrinologist Lebedeva Dilyara Ilgizovna

* Zambiri sizigwira ntchito kwa anthu omwe amaphatikiza kunenepa kwambiri, matenda ashuga kapena zovuta zina za kagayidwe kazakudya. Kulandila kwa metformin mu nkhaniyi kumayambitsidwa ndi chisonyezo chachindunji, monga hypoglycemic.

Oral hypoglycemic mankhwala

Kutulutsa mawonekedwe, kapangidwe kake ndi ma CD

Mapiritsi Othandizira Operic yoyera, yozungulira, ya biconvex.

1 tabumetformin hydrochloride 500 mg

Omwe amachokera: povidone K90, wowuma chimanga, crospovidone, magnesium stearate, talc.

Mapangidwe a Shell: methaconic acid ndi methylryacoplate copolymer (Eudragit L 100-55), macrogol 6000, titanium dioxide, talc.

Ma PC 10 - matuza (3) - mapaketi a makatoni.

Zotsatira za pharmacological

Metformin imalepheretsa gluconeogenesis m'chiwindi, amachepetsa kuyamwa kwa m'matumbo, imakulitsa kugwiritsidwa ntchito kwa glucose, komanso kumakulitsa chidwi cha minofu kulowa insulin.

Sichikukhudzana ndi kubisika kwa insulini ndi ma cell a beta, sikuti kumayambitsa kutengeka kwa hypoglycemic. Amachepetsa mulingo wa ma triglycerides ndi ma linoprotein otsika m'magazi. Imakhazikika kapena kuchepetsa thupi.

Ili ndi fibrinolytic mwina chifukwa chokakamira minofu ya plasminogen activator inhibitor.

Kuyanjana kwa mankhwala osokoneza bongo

Kugwiritsa ntchito nthawi yomweyo danazol osavomerezeka kuti apewe hyperglycemic zotsatira za chomaliza. Ngati mankhwala a danazol akufunika ndipo atayimitsa koyamba, kusintha kwa ayodini wa metformin kumafunikira kuti azitha kuyendetsa glycemia.

Kuphatikiza komwe kumafunikira chisamaliro chapadera: chlorpromazine - pamene imwedwa mu Mlingo waukulu (100 mg / tsiku) kumakulitsa glycemia, kuchepetsa kutulutsa kwa insulin.

Mankhwalawa antipsychotic ndipo atasiya kuyimilira, kusintha kwa metformin kumafunika muulamuliro wa glycemia.

Pogwiritsa ntchito munthawi yomweyo ndimomwe zimachokera ku sulfonylurea, acarbose, insulin, NSAIDs, ma inhibitors a MAO, oxytetracycline, ACE inhibitors, clofibrate zotumphukira, cyclophosphamide, β-blockers, ndizotheka kuwonjezera mphamvu ya hypoglycemic ya metformin.

Pogwiritsa ntchito munthawi yomweyo ndi GCS, kulera pakamwa, epinephrine, sympathomimetics, glucagon, mahomoni a chithokomiro, thiazide ndi loop diuretics, zotumphukira zochokera mu mtima, zotuluka za nicotinic acid, kuchepa kwa mphamvu ya hypoglycemic ya metformin ndikotheka.

Cimetidine amachepetsa kuchotsedwa kwa metformin, yomwe imawonjezera chiopsezo cha lactic acidosis.

Metformin itha kufooketsa mphamvu ya ma anticoagulants (zotumphukira za coumarin).

Kumwa mowa mwauchidakwa kumawonjezera mwayi wokhala ndi lactic acidosis panthawi yoledzera ya pachimake, makamaka ngati akusala kapena kutsatira zakudya zochepa zopatsa mphamvu, komanso ngati chiwindi chikulephera.

Mimba komanso kuyamwa

Pokonzekera kutenga pakati, komanso ngati muli ndi pakati mukamamwa Metformin, iyenera kuthetsedwa ndipo mankhwala a insulin ayenera kuyikidwa. Popeza palibe chidziwitso pakulowera mkaka wa m'mawere, mankhwalawa amadziwikiridwa pakuyamwa. Ngati mukufuna kugwiritsa ntchito Metformin panthawi yoyamwitsa, kuyamwitsa kuyenera kuyimitsidwa.

Migwirizano ndi magwiritsidwe akusungidwa

Sungani pamalo owuma, amdima pa kutentha 15 15 mpaka 25 ° C. Pewani kufikira ana. Nthawi yodikira ndi zaka zitatu.

Kufotokozera kwa mankhwala METFORMIN kumadalira malangizo ovomerezeka ovomerezeka oti agwiritsidwe ntchito ndikuvomerezedwa ndi wopanga.

Kodi mwapeza cholakwika? Sankhani ndikusindikiza Ctrl + Lowani.

Metformin Sandoz 500 mg ndi 850: mtengo, ndemanga

Metformin Sandoz ndi amodzi mwa mankhwala odziwika omwe amagwiritsidwa ntchito onse amtundu wa shuga I kuphatikiza jakisoni wa insulin komanso matenda a mtundu II, pamene maphunziro olimbitsa thupi komanso kudya moyenera sizipereka kuchepa kwa shuga.

Chifukwa cha zomwe zimagwira, kuchepa kwa kuchuluka kwa shuga kumachitika mu seramu yamagazi, ndipo kufunika kwa glucose kumacheperanso.

Monga mukudziwa, mankhwala aliwonse ali ndi zotsutsana zingapo, zoyipa ndi zina za mankhwala. Chifukwa chake, ndikofunikira kudziwa zambiri momwe zingathekere za mankhwalawa. Momwe mungagwiritsire ntchito mankhwalawa?