Zotsatira za Bayeta pa matenda ashuga

Popeza nkhani yokhudza mankhwalawo idawonekera patsamba lathu "Baeta", yomwe imagwiritsidwa ntchito pochiza matenda a shuga a 2, zoposa chaka chimodzi zatha. Munthawi imeneyi, "Baeta" idadziwika kwambiri mdera la mayiko omwe kale anali USSR ndipo idayamba kupezeka kwa odwala matenda ashuga.

Lero tikambirana za mankhwalawa mwatsatanetsatane, tilingalire mbiri ya momwe adapangidwira kuti timvetsetse momwe zimakhudzira thupi la odwala matenda ashuga, momwe amasiyanirana ndi mankhwala ena, momwe angagwiritsidwire ntchito komanso zomwe zingayambitse.

Ku North America, mitundu yapadera ya abuluzi imakhala, yomwe imangodya katatu kokha pachaka. Nthawi yomweyo amamwa chakudya chochuluka kwambiri - mpaka gawo limodzi mwa magawo atatu a kulemera kwawo konse.

Poganizira zodabwitsa zachilengedwe zamtchirezi, asayansi aku America apeza kuti malovu a nyama imeneyi ali ndi chinthu exendin. Buluzi ikalowa m'mimba yodutsa ndi njira yoyendayenda exendin zimathandizira ngakhale kugawa michere kwakanthawi. Ndiye kuti, chakudya chimatengedwa pang'onopang'ono, ndichifukwa chake magawo osowa kwambiri amtundu wa nyama amayambitsidwa.

Chifukwa cha zosintha momwe mavu a nyama iyi yachitikira, mankhwala a Bayeta aonekera, ali ndi ntchito yogwira exenatide.
Chowonekeracho pochiza matenda a shuga a 2 ndikuti amathandizira kuchepetsa thupi la wodwala. Ngakhale mankhwala ambiri omwe amagwiritsidwa ntchito pazomwezi amapangitsa zotsatirapo zosiyana.

Ngati mukuwona kuti chimodzi mwazomwe zimayambitsa matendawa ndi onenepa kwambiri komanso kunenepa kwambiri, ndiye kuti kugwiritsa ntchito mtundu 2 shuga imatha kuonedwa ngati yankho la mavuto awiri nthawi imodzi.

Malinga ndi ndemanga ndi zofalitsa zosiyanasiyana, Byte amagwiritsidwa ntchito kawiri patsiku. Pankhaniyi, insulin siigwiritsidwa ntchito. Koma mtundu 2 chithandizo cha matenda ashuga yogwirizana ndi kugwiritsa ntchito mankhwala ena.
Kukhazikitsidwa kwa mankhwalawa Byte kumachitika mu ntchafu, kutsogolo kapena pamimba, mu subcutaneous mafuta. Cholembera chokhazikika chimagwiritsidwa ntchito pamenepa.

Byte angagwiritsidwe ntchito kokha pochiza matenda amtundu wa 2 shuga. Sitikulimbikitsidwa kugwiritsa ntchito mankhwalawa pamaso pa matenda monga matenda ashuga a ketocidosis, kulephera kwa impso, matenda amtundu wamatumbo, komanso chidwi chochulukirapo pazigawo zosiyanasiyana za mankhwalawa.

Bayeta sangalembedwe kwa ana ochepera zaka 18, ogwiritsira ntchito panthawi yomwe ali ndi pakati komanso poyamwitsa.

Pali kulangizidwa.

Mankhwala kutumikiridwa 1 ora pamaso chakudya, 2 pa tsiku. Mlingo, kuchepa kwake kapena kuwonjezeka kwake ndikofunikira kuti akambirane ndi adokotala.

Simungagwiritse ntchito bafa ngati yankho likuwoneka ngati lamitambo, tinthu tating'onoting'ono timapezeka mwa iwo kapena tili ndi mtundu wokayikitsa. Sitikulimbikitsidwa kugwiritsa ntchito mukangodya. Intramuscular and intravenous management of byte solution siziganizira.

Mukamagwiritsa ntchito maantibayotiki osiyanasiyana, amayenera kumwedwa ola limodzi asanakwane mankhwala.

Musanagwiritse ntchito mankhwala Baeta pochizira matenda a shuga a mtundu wachiwiri, muyenera kufunsa dokotala!

Dzinalo Losayenerana

INN Bayeta - Exenatide.

Baeta ndi hypoglycemic wothandizira kupangira matenda amtundu wa II shuga, mankhwala othandiza kwambiri popanga mankhwala.

Mankhwalawa ndi a gulu la pharmacological lopanga ma hypoglycemic othandizira othandizira matenda a shuga a insulin, ndipo ali ndi code ya AXX ya A10X.

Kutulutsa mafomu ndi kapangidwe kake

Mankhwala amapezeka mu mawonekedwe a jekeseni wothandizidwa ndi subcutaneous makonzedwe. Ndi madzi amadzimadzi, opanda mtundu ndi fungo. Yake yogwira mankhwala exenatide imakhala ndi 250 μg pa 1 ml ya yankho. Udindo wa zosungunulira umaseweredwa ndi madzi a jakisoni, ndipo kudzazidwa kothandizira kumayimiriridwa ndi metacresol, sodium acetate trihydrate, acetic acid, ndi mannitol (zowonjezera E421).

Njira yothetsera 1.2 kapena 2.4 ml imathiridwa m'makalata agalasi, omwe amayikidwa mu cholembera cha syringe - analogue ya jakisoni wa insulin. Katakitala wakunja. Pali syringe imodzi yokha ndi mankhwala m'bokosi.

Kukonzekera kosasunthika kosasinthika kumapezeka komwe kumapezeka mu ufa wa fomu pokonzekera osakaniza oyimitsidwa. Mafuta omwe amayamba amagwiritsidwanso ntchito ngati jekeseni wa subcutaneous. Dongosolo la ufa (2 mg) limathiridwa mu cartridge yomwe imayikidwa mu cholembera. Chithunzichi chimaphatikizira chosakanikirana ndi malangizo.

Bayeta ndi kapu yamagalasi yokhala ndi jakisoni wovomerezeka wa kasamalidwe koyenda, yoyikidwa mu ma syringe otayika.

Zotsatira za pharmacological

Zotsatira za mankhwalawa zimaperekedwa ndi ntchito ya exenatide (exendin-4).

Chipangizo chopangira ichi ndi unyolo wa amino peptide wopanga zinthu 39 za amino acid.

Izi ndi mawonekedwe a enteroglucagon, mahomoni a peptide omwe amapezeka m'thupi la munthu, omwe amatchedwanso glucagon-like peptide-1, kapena GLP-1.

Ma insretins amapangidwa ndi maselo a kapamba ndi matumbo pambuyo chakudya. Ntchito yawo ndikuyambitsa kutulutsa insulini. Chifukwa cha kufanana kwake ndi zinthu zamafuta izi, exenatide imakhudzanso thupi. Kuchita ngati GLP-1 mimetic, ikuwonetsa zochizira zotsatirazi:

• imalimbikitsa kutulutsa kwa insulin ndi ma pancreatic β-cell ndi kuchuluka kwa plasma glucose,
• Amachepetsa katulutsidwe wa glucagon, osasokoneza kuyankha kwa hypoglycemia,
• imaletsa ntchito yam'mimba, ndikuchepetsa,
• imayang'anira kukonzekera
• amachepetsa kuchuluka kwa chakudya,
• amalimbikitsa kuchepa thupi.

Malangizo a Byetta - kukonda Kodi mtundu 2 wa shuga m'mawu osavuta

Mtundu wachiwiri wa shuga, matenda a pancreatic β-cell amawonongeka, zomwe zimapangitsa kuti insulin itulutsidwe. Exenatide amakhudza magawo onse a insulin secretion. Koma panthawi imodzimodzi, kukula kwa ntchito ya β-maselo oyambitsidwa ndi iye amachepetsa ndi kuchepa kwa ndende ya glucose. Kutenga kwa insulini kumayima panthawi yomwe index ya glycemic ibwerera mwachizolowezi. Chifukwa chake, kuyambitsa mankhwala omwe akufunsidwa kumachepetsa mwayi wokhala ndi hypoglycemia.

Kafukufuku wachipatala awonetsa kuti chithandizo choterechi chimapereka mwayi wowongolera shuga wamagazi mwa odwala omwe ali ndi matenda a shuga a 2.

Pharmacokinetics

Pambuyo pa utsogoleri wa Baeta mwanjira ya jakisoni wansinga, mankhwalawo amayamba kulowetsedwa m'magazi, mpaka kufika pakufika msanga pafupifupi maola awiri.

Chiwerengero chonse cha exenatide chimawonjezeka molingana ndi kuchuluka kwa mlingo womwe umalandiridwa mu 5-10 μg.

Mankhwala Baeta amafika pakukweza kwake m'magazi 2 pambuyo pa kuponderezedwa ndipo amachotsedwa m'thupi pakatha maola 10.

Kusintha kwa mankhwalawa kumachitika ndi zida za impso, mapuloteni a proteinolytic amakhudzidwa ndi kagayidwe. Zimatenga pafupifupi maola asanu kuchotsa zochuluka za mankhwalawo m'thupi, mosasamala kuchuluka kwa mankhwalawa. Kuyeretsa kwathunthu kwa thupi kumatenga maola 10.

Zizindikiro zogwiritsidwa ntchito

Mankhwala akuwonetsedwa kuti akonzedwa mokwanira m'magazi a shuga. Byetu angagwiritsidwe ntchito ngati mankhwala a hypoglycemic a monotherapy. Kuchita jakisoni koteroko kumathandiza ngati chakudya choyenera chikutsatiridwa ndikuchita zolimbitsa thupi nthawi zonse.

Mankhwalawa atha kuphatikizidwa mu maphunziro ophatikizika ndi kusakwanira kwa mankhwalawa ndi ena antiglycemic othandizira. Kuphatikiza zingapo kwa mankhwala ndi Bayeta ndikuloledwa:

1. Sulfonylurea derivative (PSM) ndi Metformin.
2. Metformin ndi Thiazolidinedione.
3. PSM yokhala ndi Thiazolidinedione ndi Metformin.

Malingaliro oterewa amatsogolera kuchepa kwa kuthamanga kwa shuga m'magazi ndikatha kudya, komanso glycemic hemoglobin, yomwe imakweza kuwongolera kwa glycemic kwa odwala.

Bayeta imalembedwa kuti ikonzedwe kokwanira pa glycemic, ndipo itha kugwiritsidwanso ntchito ngati monotherapy.

Contraindication

Mankhwala sangathe kugwiritsidwa ntchito ngati matenda a shuga 1. Zotsutsa zina:

• kuchuluka kwa zotumphuka,
• tsankho ku zowonjezera zowonjezera,
• ketoacidosis
• kuwonongeka kwa chakudya cham'mimba, limodzi ndi kuchepa kwa ntchito ya minofu ya m'mimba
• yoyamwitsa kapena pakati,
• kulephera kwambiri kwaimpso
• wazaka 18.

Kuyamwitsa ndi imodzi mwazinthu zotsutsana pakugwiritsa ntchito mankhwala a Bayet.

Kodi kutenga bayetu?

Dokotala ali ndi udindo wopereka mankhwalawo, kudziwa kuchuluka kwa mulingo woyenera ndikuwunika momwe wodwala alili ndi matenda a shuga. Ndikulimbikitsidwa kwambiri kuti musamadzipewe mankhwala omwe mumalandira.

Jekeseni imayendetsedwa pansi pa khungu m'dera la brachial, chikazi kapena pamimba. Tsamba la jakisoni la mankhwalawa silikuwonetsa kukhudzika kwake.

Poyamba, mlingo umodzi ndi 0.005 mg (5 μg). Jakisoni amaperekedwa musanadye chakudya cham'mawa komanso chamadzulo. Kusiyana kwakanthawi pakati pa kukhazikitsidwa kwa mankhwalawa ndi chiyambi cha chakudya sikuyenera kupitirira 1 ora.

Pakati pa zakudya zazikulu, zomwe zimagwirizanitsidwa ndi kugwiritsa ntchito mankhwalawa, osachepera maola 6 ayenera kudutsa.

Pakatha mwezi umodzi chithandizo, limodzi mlingo umatha kuwirikiza. Jakisoni wosaiwalika sikutanthauza kuchuluka kwa mankhwalawa ndi kuperekera kwa mankhwala. Mukatha kudya Bayetu sayenera kudulidwa.

Momwemonso kugwiritsidwa ntchito kwa mankhwalawa pofunsa ndi sulfonylurea kukonzekera, adokotala amatha kuchepetsa kuchuluka kwa zotsatira zakumapeto chifukwa chakukula kwa vuto la hypoglycemic. Chithandizo chophatikiza ndi Thiazolidinedione ndi / kapena Metformin sichitengera kusintha kwa Mlingo woyamba wa mankhwalawa.

Zotsatira zoyipa

Zotsatira zoyipa zomwe zimachitika chifukwa cha exenatide zimakhala zolimbitsa thupi ndipo sizifuna kuti discontinuation ya mankhwala (kupatula zina). Nthawi zambiri, pamayambiriro a mankhwalawa ndi Bayeta wokhala ndi mulingo wa 5 mg kapena 10 mg, nseru imawonekera, yomwe imazimiririka yokha kapena itatha kusintha kwa mlingo.

Kuchepetsa mphuno ndi njira yoyipa yochititsidwa ndi mankhwala a Bayet, omwe nthawi zambiri amawonetsedwa koyambira kwamankhwala.

Matumbo

Nthawi zambiri, odwala amakhala ndi vuto logaya m'mimba. Odwala amadandaula za nseru, kuchepa kwa chilala, kusanza, kukanika, kupweteka pamimba. Kutheka Reflux, maonekedwe a belching, flatulence, kudzimbidwa, kuphwanya kwa kuzindikira kwa kukoma. Milandu ingapo ya kapamba owopsa amadziwika.

Pakati mantha dongosolo

Nthawi zambiri odwala amakhala ndi migraines. Amatha kumva chizungulire kapena kusowa tulo masana.

Migraines ndi njira imodzi yodziwika yomwe imagwiritsidwa ntchito ndi mankhwala a Bayet kuchokera ku dongosolo lalikulu lamanjenje.
Chifukwa chogwiritsa ntchito mankhwala a Bayeta, odwala amatha kumva kuti ali ndi chizungulire.
Zovuta zakugona masana ndizotheka chifukwa chakugwiritsa ntchito Byeta.

Pa khungu

Pamalo jakisoni, zizindikiro zoyipa zitha kuonedwa.

Thupi lawo siligwirizana n`zotheka mawonekedwe a khungu totupa, kuyabwa, redness, kutupa. Mawonekedwe a anaphylactic samawonedwa kawirikawiri.

Khungu la Itchy limakhala losavomerezeka pakugwiritsa ntchito mankhwala a Bayet.

Malangizo apadera

Ngati mtundu, mawonekedwe, kapena kufanana kwa jakisoni wamadzi wasintha, sungagwiritsidwe ntchito. Muyenera kutsatira njira yoyenera yothandizira mankhwalawa. Jekeseni sichimaperekedwa kudzera m'mitsempha kapena m'mitsempha.

Kuzindikira kwamlingo kapena kuchepa thupi kwa wodwalayo sikuti kukuwonetsani kuti mukumwa mankhwala osokoneza bongo, kusintha kwa mlingo wake komanso pafupipafupi pakugwiritsa ntchito.

Potengera kuyambitsa kwa exenatide, ma antibodies amatha kupangidwa mthupi. Izi sizikhudza kuwonekera kwa zizindikiro zammbali.

Gwiritsani ntchito mu ukalamba

Mankhwala a pharmacokinetics samatengera zaka za odwala. Chifukwa chake, palibe chifukwa chosinthira mlingo wa okalamba.

Kukalamba sikukulepheretsa kugwiritsa ntchito mankhwala a Bayet, komanso sikutanthauza kusintha mtundu wa mankhwalawa.

Kugwiritsa ntchito kwa vuto la chiwindi

Chifukwa chakuti nkhawa yayikulu yothetsa exenatide imagwera impso, zolakwika za chiwindi kapena chikhodzodzo sindikuwunikira chifukwa chogwiritsa ntchito mankhwalawa ndipo osakakamiza ziletso.

Kulephera kwa chiwindi kapena ndulu ya ndulu sikukutsutsana pakugwiritsa ntchito mankhwalawa.

Mankhwala osokoneza bongo a Byeta

Kugwiritsa ntchito mulingo wambiri wa exenatide kumabweretsa hypoglycemia. Poterepa, jakisoni kapena dontho la glucose limafunikira. Zizindikiro za bongo:

• kulumikizana
• kusanza
• shuga wa m'madzi ochepa
• cholembera chazithunzi,
• kuzizira
• mutu
• thukuta
• arrhasmia,
• mantha
• kuchuluka kwa kuthamanga kwa magazi:
• kunjenjemera.

Arrhythmia ndi chimodzi mwazizindikiro za Bayet.

Kuchita ndi mankhwala ena

Kuphatikiza yankho ndi mankhwala ena opakidwa mu syringe imodzi ndikuloledwa.

Muyenera kukumbukira kutsika kwam'mimba pansi pa zochita za exenatide mukamamwa mankhwala osokoneza bongo mkati, chifukwa kuchuluka kwa mayamwidwe ndi mayamwidwe kumatha kuchepetsedwa kwambiri. Ndalama zoterezi zimayenera kutengedwa nthawi yayitali asanakhazikitsidwe kwa Byeta, nthawi yocheperako ndi ola limodzi. Ngati mankhwalawa amafunika kudya ndi chakudya, ndiye kuti ayenera kukhala chakudya chomwe sichimalumikizidwa ndi jakisoni wa wothandizira wa hypoglycemic.

Proton pump zoletsa ayenera kumwedwa patatha maola 4 jekeseni kapena ola limodzi lisanachitike.

Pogwiritsa ntchito warfarin kapena kukonzekera kwanyanjayi, kuwonjezeka kwa nthawi ya prothrombin ndikotheka. Chifukwa chake, kuphatikizika kwa magazi kuyenera kuyendetsedwa.

Ngakhale kugwiritsidwa ntchito kophatikizana kwa Bajeta ndimankhwala omwe amalepheretsa kuchepa kwa HMG-CoA sikuyambitsa kusintha kwakukulu pakuphatikizika kwa magazi, tikulimbikitsidwa kuwunikira cholesterol.

Kuphatikiza kwa mankhwalawa komwe kumafunsidwa ndi Lisinopril sikuyambitsa kusintha kwa kuthamanga kwa magazi mwa wodwala.

Kuphatikiza jakisoni wa Bajeta ndi njira yolerera pakamwa sikutanthauza kusintha kwa mlingo.

Sikoyenera kuti muzisamalira panjira zapakati pa jekeseni la Bayeta ndikumwa mankhwala - omwe amachokera ku sulfanylurea.

Ndi kaphatikizidwe / kayendetsedwe kamodzi ka Bayeta ndi Warfarin, kuphatikizika kwa magazi kuyenera kuyendetsedwa.

Kuyenderana ndi mowa

Ndikosayenera kumwa mowa kapena mankhwala akumwa.

Pali mitundu iwiri yokha ya mankhwala - Exenatide ndi Baeta Long. Otsatirawa a hypoglycemic ali ndi zotere:

Generic Baeta - Bydureon (Bydureon).

Victoza ndi othandizira a hypoglycemic omwe amakhalanso ndi Bayeta.

Tsiku lotha ntchito

Mwanjira yake yoyambirira, mankhwalawa amasungidwa kwa zaka ziwiri. Mukatsegula phukusi, liyenera kugwiritsidwa ntchito masiku 30.

Moyo wa alumali wa mankhwala a Bayeta ndi zaka 2 momwe zidalili kale ndipo masiku 30 atatsegula phukusi.

Wopanga

Dziko lomwe adalembedwako ndi Great Britain. Komabe, kupanga mankhwalawa kumachitika ndi kampani yopanga mankhwala ku India ya Macleods Pharmaceuticals Ltd.

Alla, wazaka 29, Stavropol.

Ndigula amayi a Baitu. Zodula, koma zosavuta kugwiritsa ntchito. Poyamba, amayi ankadandaula kuti anali ndi vuto, koma posakhalitsa zinaleka.Shuga ndi okhazikika, chifukwa chake tidzapitiliza kugwiritsa ntchito mankhwalawa.

Veronika, wazaka 34, Danilov.

Ndinkawerenganso malangizowa, ndinkaona kuti sindinasangalale nawo pamndandanda wazotsatira zoyipa. Pambuyo pa jakisoni ndidadwala. Ndinaopanso kupereka mlingo wotsatira. Koma mwamuna wanga adati ndadzinyenga ndekha. Amanena zoona. Jakisoni wotsatira sanalinso wopweteka kwambiri. Dokotalayo ananena kuti mulingo sayenera kugawidwa, ndipo pambuyo pake anawonjezera. Tsopano samadwaladwala, pokhapokha nthawi zina pamakhala kusokonezeka m'mimba.

Olga, wazaka 51, mzinda wa Azov.

Ndinayamba kugwiritsa ntchito mankhwalawa kuthandiza Metformin. Anadya masiku oyamba onse kudzera mu mphamvu - chidwi chake chinali chitatha. Kenako thupi linazolowera. Magawo adayamba kuchepa, koma chidwi chidayambiranso. Tsopano ndizachidziwikire chifukwa ku America Bayetu amalembera okhawo omwe akufuna kuchepetsa thupi.

Kupanga ndi mawonekedwe a kumasulidwa

mu ma syringe zolembera okhala ndi makatoni a 1.2 kapena 2.4 ml, mu paketi ya makatoni 1 a cholembera.

Mankhwala

Exenatide (Exendin-4) ndi incretin mimetic ndipo ndi 39-amino acid amidopeptide. Ma insretins, monga glucagon-peptide-1 (GLP-1), amalimbikitsa kuteteza shuga m'magazi, amasintha ntchito ya beta, kuponderezana mosabisa kutulutsa glucagon ndikuchepetsa m'matumbo atalowetsa magazi ambiri kuchokera m'matumbo. Exenatide ndi mphamvu ya incretin mimetic yomwe imapangitsa kuti shuga ikhale yolimba ndipo imakhala ndi zotsatirapo zina za hypoglycemic zomwe zimapangidwa ndi ma insretins, zomwe zimapangitsa kuti glycemic control mu odwala omwe ali ndi matenda a shuga a 2.

Mndandanda wa amino acid wa exenatide pang'ono umafanana ndi kufanana kwa anthu a GLP-1, chifukwa chomwe chimamangiriza ndikuyambitsa zolandilira za GLP-1 mwa anthu, zomwe zimapangitsa kuti chiwonetsero cha glucose chizidalira komanso kutulutsa kwa insulin kuchokera ku maselo a beta othandizira pancreatic beta komanso nawo cyclic adenosine monophosphate (AMP) ndi / kapena njira zina zowonetsera ma intracellular. Exenatide imathandizira kutulutsa kwa insulin kuchokera ku maselo a beta pamaso pa kutsika kwa glucose.

Exenatide amasiyana mu kapangidwe ka mankhwala ndi zochita za pharmacological kuchokera ku insulin, zotumphukira za sulfonylurea, zotumphukira za D-phenylalanine ndi meglitinides, biguanides, thiazolidinediones ndi alpha-glucosidase inhibitors.

Exenatide imathandizira kuwongolera kwa glycemic mwa odwala omwe ali ndi matenda a shuga a 2 chifukwa cha machitidwe omwe alembedwa pansipa.

M'mikhalidwe ya hyperglycemic, exenatide imakulitsa katulutsidwe wama shuga a insulin kuchokera kuma cell a pancreatic beta. Katemera wa insuliniyu amathera pomwe kuchuluka kwa glucose m'magazi kumachepera ndipo kumayandikira mwachizolowezi, potero kumachepetsa chiopsezo cha hypoglycemia.

Kubisirana kwa insulin mkati mwa mphindi 10 zoyambirira, komwe kumadziwika kuti "gawo loyamba la mayankho a insulin", kulibe makamaka kwa odwala omwe ali ndi matenda a mtundu wa 2. Kuphatikiza apo, kutayika kwa gawo loyamba la mayankho a insulin ndikusokonekera koyambirira kwa ntchito ya cell ya beta mu mtundu wachiwiri wa shuga. imabwezeretsa kapena imathandizira kwambiri gawo loyamba ndi lachiwiri la kuyankha kwa insulin mwa odwala omwe ali ndi matenda a shuga a 2.

Odwala ndi mtundu 2 matenda a shuga mellitus motsutsana maziko a hyperglycemia, makonzedwe a exenatide amachepetsa kwambiri secretion wa glucagon. Komabe, exenatide sichimasokoneza mayankho abwinobwino a glucagon ku hypoglycemia.

Zinawonetsedwa kuti kukhazikika kwa exenatide kumayambitsa kutsika kwa kudya komanso kuchepa kwa chakudya, kumalepheretsa matumbo, omwe amatsogolera pakuchepa kwake.

Odwala omwe ali ndi mtundu wachiwiri wa matenda a shuga, mankhwalawa a exenatide akuphatikizidwa ndi metformin ndi / kapena sulfonylurea kukonzekera kumayambitsa kutsika kwa glucose wamagazi, postprandial magazi glucose, ndi glycosylated hemoglobin index (HbA1c), potero kukonza kuwongolera kwa glycemic mwa odwala.

Mlingo ndi makonzedwe

S / c mpaka pa ntchafu, pamimba, kapena pamphumi.

Mlingo woyamba ndi 5 mcg, womwe umaperekedwa kawiri / tsiku lililonse nthawi iliyonse mphindi 60 musanadye chakudya cham'mawa ndi chamadzulo. Musamwe mankhwala mukatha kudya. Ngati jakisoni wa mankhwalawo akusowa, chithandizo chimapitilira osasintha mlingo.

Patatha mwezi umodzi chiyambire chithandizo, mlingo wa mankhwalawa ukhoza kuchuluka mpaka 10 mcg 2 nthawi / tsiku.

Kuphatikizidwa ndi metformin, thiazolidinedione, kapena kuphatikiza kwa mankhwalawa, mlingo woyambirira wa metformin ndi / kapena thiazolidinedione sungasinthidwe. Pankhani ya kuphatikiza kwa Bayeta ® ndi zotumphukira zochokera ku sulfonylurea, njira yochepetsera kupezeka kwa sulfonylurea ingafunike kuti muchepetse chiopsezo cha hypoglycemia.

Mlingo ndi njira ya makonzedwe a mankhwala a BAETA

Jekeseni wa mankhwalawa amapangidwa m'mimba, ntchafu, phewa.

Mlingo woyambirira ndi 5 mcg, kutumikiridwa kawiri pa tsiku, kwa mphindi 60 musanadye chakudya cham'mawa komanso chakudya chamadzulo. Mukatha kudya, mankhwalawa osavomerezeka. Ngati jakisoni waphonya, musangowonjezera muyezo pazotsatira zamtundu wotsatira.

Mlingo ukuwonjezeka mu mwezi mpaka 10 mcg kawiri pa tsiku.

Matenda a 2 a shuga: monotherapy kapena kuwonjezera pa mankhwalawa ndi metformin, sulfonylurea ndi mankhwala a thiazolidinedione omwe ali ndi glycemic control control.