Acetylsalicylic acid: malangizo ogwiritsira ntchito

Acetylsalicylic acid, ikamamwa, imathandizira kusokoneza mapangidwe a ma prostaglandins, zinthu zomwe zimagwira gawo lalikulu pakukweza zigawo za febrile, kutupa ndi kupweteka.

Kuponderezedwa kwa kupanga kwa ma prostaglandins kumayambitsa kukulitsa kwamitsempha yamagazi, yomwe imathandizira kuwonjezera kugawaniza kwa thukuta, lomwe limafotokoza mphamvu ya antipyretic ya mankhwalawa.

Kugwiritsa ntchito mankhwala ozikidwa pa acetylsalicylic acid mu mankhwala kumayambitsa kutsika kwa chidwi cha mathero am'mitsempha, omwe amafotokozera analgesic zotsatira za mankhwalawa. Acetylsalicylic acid umachotsedwa kudzera mu impso.

Zomwe zimathandiza acetylsalicylic acid

Acetylsalicylic acid mapiritsi amathandizidwa kuti achikulire azichitira ndi kupewa zotsatirazi:

Pachimake yotupa njira - kutukusira kwa mtima thumba, nyamakazi, chorea, chibayo ndi kuchuluka monga mbali zovuta zovuta, zotupa zotupa za periarticular thumba,
Ululu wamankhwala ochokera kumayendedwe osiyanasiyana - kupweteka kwambiri kwa mutu, kupweteka kwa mano, kupweteka kwa minyewa ndimatenda a chimfine ndi mavairasi, kupweteka kwa msambo, migraines, kupweteka kwapawiri
Matenda a msana omwe amaphatikizidwa ndi kupweteka kwambiri - osteochondrosis, lumbago,
Kuwonjezeka kwa kutentha kwa thupi, kutentha thupi chifukwa cha matenda opatsirana ndi kutupa
Kupewa kwa chitukuko cha myocardial infarction kapena ischemic stroke ngati magazi atha kusokonekera, ma thromboaggregation, magazi akuda kwambiri,
Angina pectoris wachikhalidwe chokhazikika,
Tizeru zakukula kwa thromboembolism, thrombophlebitis,
Zofooka za mtima, mitral valve prolapse (ntchito yopuwala),
Pulmonary infarction, pulmonary thromboembolism.

Contraindication

Mapiritsi acetylsalicylic acid ali ndi zotsutsana zingapo kuti mugwiritse ntchito. Izi zikuphatikiza:

Hemorrhagic diathesis ndi vasculitis,
Gastritis yachisokonezo kapena chowononga,
Zilonda zam'mimba ndi duodenum,
Kuchepa kwam magazi, kusokonekera kwa magazi,
Vitamini K akusowa
Exortating Aortic Aneurysm,
Kusokonezeka kwakukulu kwa impso ndi chiwindi.
Hemophilia
Kusalolera payekha kwa salicylates kapena thupi lawo siligwirizana ndi acetylsalicylic acid m'mbiri
Arterial matenda oopsa, chiopsezo cha hemorrhagic stroke.

Acetylsalicylic acid uzitenga bwanji?

Mapiritsi a acetylsalicylic acid ndi othandizira pakamwa. Mankhwala tikulimbikitsidwa kumwedwa kumayambiriro kwa chakudya kapena atangomaliza kudya kuti aletse kukokoloka kwa msana. Mapiritsi amatha kutsukidwa ndi mkaka, kotero kuti kukwiya kwa acetylsalicylic acid pamitsempha yamkamwa pakamwa sikungakhale kovuta kwambiri kapena kugwiritsa ntchito madzi amchere wamba opanda mpweya wokwanira.

Akuluakulu amayikidwa piritsi limodzi la 500 mg ya mankhwalawa 2-4 patsiku, malingana ndi zomwe zikuwonetsa ndi thanzi lonse. Mlingo wapamwamba wa tsiku ndi tsiku ndi 3 g ndipo sungathe kupitirira! Kutalika kwa mankhwalawa ndi mankhwalawa kumatsimikiziridwa ndi adokotala kutengera ndi mawonekedwe, kuopsa kwa njira yotupa ndi mawonekedwe a munthu payekhapayekha, koma nthawi imeneyi sayenera kupitirira masiku 10-12.

Mwa zolinga za prophylactic, kuti muchepetse chiopsezo chokhala ndi myocardial infarction ndi thromboaggregation, achikulire amalembedwa ½ mapiritsi a aspirin 1 nthawi patsiku. Kutalika kwa mankhwalawa kuli pafupifupi miyezi iwiri. Munthawi imeneyi, ndikofunikira kuwunika pafupipafupi chithunzi cha magazi, kuwunika kuchuluka kwa magazi ndi kuchuluka kwa mapulateleti.

Zotsatira zoyipa

Musanagwiritse ntchito mapiritsi a acetylsalicylic acid, wodwalayo ayenera kufunsa dokotala. Ngati mulingo wapitirira kapena osagwiritsidwa ntchito mosagwiritsa ntchito mankhwalawa kwa nthawi yayitali, zotsatirapo zake zingakhale:

Kupweteka kwa epigastric, nseru, kusanza,
Kutsegula m'mimba
Chizungulire ndi kufooka
Kuchepetsa chidwi
Zowonongeka,
Kutulutsa magazi - matumbo, mphuno, gingival, chapamimba,
Kusintha kwa chithunzi cha magazi - magazi achepetsa kuchuluka kwa hemoglobin ndi mapulateleti,
Kuphwanya chiwindi ndi impso,
Kukula kwa aimpso aimpso kulephera,
Bronchospasm, mu milandu yayikulu, kukula kwa angioedema ndi anaphylactic.

Kugwiritsa ntchito mankhwalawa pa mimba komanso mkaka wa m`mawere

Mankhwala acetylsalicylic acid saloledwa kumwa 1 ndi 3 ma trimesters omwe ali ndi pakati.

Malinga ndi kafukufuku, kugwiritsa ntchito mapiritsi a aspirin mwa amayi apakati m'milungu 12 yoyambirira kumawonjezera mwayi wokhala ndi vuto la mluza, ndiko kuti, kufinya kwamkati ndi zofooka zamtima zatsopano.

Kugwiritsa ntchito mankhwalawa munthawi ya 2 ndikotheka mosamala kwambiri pokhapokha ngati phindu lomwe likuyembekezeredwa kwa mayi lidzakhala lalikulu kuposa momwe zingavulaze mwana wosabadwayo. Mapiritsi amagwiritsidwa ntchito muyezo wowerengeka (wogwira bwino ntchito) komanso moyang'aniridwa ndi achipatala. Panthawi yamankhwala, mayi woyembekezera ayenera kuyezetsa magazi pafupipafupi kuti awerenge hematocrit ndi ma protein.

Kugwiritsa ntchito acetylsalicylic acid mu 3 trimester ndi koletsedwa chifukwa cha chiwopsezo chachikulu chotsekedwa koyambirira kwa aortic duct mu fetus. Kuphatikiza apo, mankhwalawa amatha kubweretsa kukondoweza kwamitsempha yaubongo mu fetus ndikupangitsa kuti magazi achitike mwa mayi woyembekezera.

Kugwiritsa ntchito mapiritsi a acetylsalicylic acid pa nthawi yoyamwitsa ndi koletsedwa chifukwa cha chiwopsezo chachikulu chotenga chiwindi ndi impso kulephera kwa mwana. Kuphatikiza apo, kulowa m'thupi la mwana wakhanda wokhala ndi mkaka wa amayi, acetylsalicylic acid imatha kutulutsa magazi kwambiri kwa mwana. Ngati kuli kofunikira kugwiritsa ntchito mankhwalawa panthawi yoyamwitsa, mwana ayenera kupita ku chakudya chamagulu chophatikizira mkaka.

Kuchita ndi mankhwala ena

Kugwiritsa ntchito pamodzi kwa mapiritsi a aspirin ndimankhwala ena ochokera pagulu la zinthu zosapatsa mankhwala a antibidal (ibuprofen, nuroferon, indomethacin ndi ena) kumawonjezera chiopsezo cha mavuto obwera pamwambapa ndi zizindikiro zosokoneza bongo. Nthawi zina, odwala adayamba kulephera komanso kukomoka.

Ndi munthawi yomweyo kugwiritsa ntchito acetylsalicylic acid ndi mankhwala kuchokera ku gulu la antacid, kuchepa kwa njira zochiritsira za aspirin komanso kuchepa kwake pakulowetsedwa m'magazi kumawonedwa.

Mapiritsi a Acetylsalicylic acid aletsedwa kumwa nthawi yomweyo ndi anticoagulants chifukwa chowonjezeka kwambiri cha kuthekera kwa kutulutsa magazi kwakanthawi komanso kuwonda kwambiri kwa magazi.

Momwe amagwiritsidwira ntchito acetylsalicylic acid okhala ndi okodzetsa, ntchito yawo yothandizidwa imachepa.

Kugwiritsa ntchito munthawi yomweyo mankhwalawa ndi ethanol kumatha kuyambitsa poizoni ndi kuledzera.

Kusunga ndi kugawa zinthu

Mapiritsi a acetylsalicylic acid amamugulitsa m'mafakisoni popanda mankhwala. Mankhwalawa amayenera kusungidwa zaka 4 kuyambira tsiku lopangira lomwe lasonyezedwa pa phukusi. Pambuyo pa nthawi imeneyi, mapiritsi sangathe kumwa pakamwa.

Sungani phukusi kutali ndi dzuwa komanso kuti ana asakufikire.

Mlingo

Mapiritsi, 500 mg

Piritsi limodzi lili

ntchito: acetylsalicylic acid - 500 mg

zokopa: wowuma mbatata, stearic acid, citric acid monohydrate, talc

Mapiritsi ochepera-cylindrical, oyera, amtundu wamkati komanso osakhazikika, osalala pang'ono

Mankhwala

Pharmacokinetics

Pambuyo pakukonzekera kwamlomo, acetylsalicylic acid imasandulika kukhala metabolite yayikulu - asidi salicylic. Kuperewera kwa acetylsalicylic ndi salicylic acids m'mimba mwake kumachitika msanga komanso mokwanira. Kuzindikira kwakukulu kwa plasma kumachitika pambuyo pa mphindi 10-20 (acetylsalicylic acid) kapena mphindi 45-120 (masalicylates athunthu). Mlingo womanga ma acid ndi mapuloteni a plasma umatengera ndende, yomwe ndi 49-70% ya acetylsalicylic acid ndi 66-98% ya salicylic acid. 50% ya mankhwala omwe amaperekedwa ndi mankhwalawa imaphatikizidwa pakadutsa koyamba kudzera pachiwindi.

Mankhwala amawoloka chotchinga cha magazi, ndipo amadziwikanso mkaka wa m'mawere ndi madzi amitsempha yamagazi.

Ma metabolabol a acetylsalicylic ndi salicylic acids ndi glycine conjugate wa salicylic acid, njonda acid ndi glycine conjugate yake. The biotransfform ya salicylates imachitika makamaka mu chiwindi ndikupanga 4 main metabolites omwe amapezeka mumtundu wambiri ndi mkodzo. Kutulutsa kwa salicylates kumachitika makamaka kudzera mwa katulutsidwe ka impso m'matumbo a impso osasinthika (60%) komanso ma metabolites. Mlingo wa kuchotserera umadalira mlingo - mukamamwa Mlingo wocheperako, theka la moyo ndi maola 2-3, ndipo ndi kuchuluka kwa mankhwalawa kumatha kuwonjezeka mpaka maola 15-30. Mwa makanda, kuchotsa kwa ma salicylates kumayamba pang'onopang'ono kuposa akuluakulu. Mphamvu yotsutsa-yotupa ya mankhwalawa imachitika pambuyo pa masiku 1-2 pambuyo pa kupangika (atapanga nthawi yayitali mankhwalawa amtundu wa silicylates, womwe umakhala pafupifupi 150-300 μg / ml), umafika pamlingo wambiri wa 20-30 mg% ndipo nthawi yonse yogwiritsa ntchito imatsala.

Mankhwala

Acetylsalicylic acid ali ndi anti-yotupa, antipyretic, komanso analgesic kwenikweni.

Mphamvu yotsutsa-yotupa ya acetylsalicylic acid imafotokozedwa ndi momwe zimakhalira pakuchitika pakukonzekera: kuchepa kwa mphamvu ya capillaries, kuchepa kwa ntchito ya hyaluronidase, kuchepetsedwa kwa mphamvu yamagetsi othandizira poyambitsa kupangika kwa ATP, etc.

Antipyretic zotsatira zimagwirizana ndi kukopa kwa malo a hypothalamic a thermoregulation.

Mphamvu ya analgesic imabwera chifukwa cha magawo azomwe amamva kupweteka komanso kuthekera kwa salicylates kuchepetsa algogenic zotsatira za bradykinin.

Chimodzi mwazinthu zazikulu za zochita za acetylsalicylic acid ndi inactivation (suppression of shughuli) ya cycloo oxygenase enzyme (enzyme yomwe ikukhudzidwa ndi kapangidwe ka prostaglandins), chifukwa chomwe kuphatikiza kwa ma prostaglandins kusokonezeka. Kuwonongeka kwa kaphatikizidwe ka prostaglandin kumabweretsa kuchepa kwa chidwi cha zotumphukira za mitsempha yopita kumapeto kwa kinins ndi ena oyimira pakati ndi otupa ndi opweteka (otumiza). Chifukwa chophwanya mapangidwe a ma prostaglandins, kuwopsa kwa kutupa ndi mphamvu yawo ya pyrogenic (kuwonjezeka kwa kutentha kwa thupi) pazomwe zimathandizira kuchepa. Kuphatikiza apo, zotsatira za ma prostaglandins pazomvera zamitsempha zachepa zimachepetsedwa, zomwe zimayambitsa kuchepa kwa chidwi chawo kwa oyimira pakati opweteka. Ilinso ndi antiaggregatory action.

Mphamvu yothana ndi kuchuluka kwa mankhwalawa ndikuchepetsa mphamvu ya kupatsidwa zinthu zamagazi ndi ma cell ena am'magazi kuti achulukane komanso kuchepetsa mwayi wokhala ndi thrombosis. Kupanga kwa izi kumalumikizidwa ndi kutsekeka kwa njira ya cycloo oxygenase ya arachidonic acid metabolism, kuletsa kwa michere ya thromboxane synthetase, phosphodiesterase, kuwonjezeka kwa kuchuluka kwa cAMP m'mapulogalamu, kuchepa kwa kuchuluka kwa calcium, kulepheretsa kwa kuphatikizika kwa maselo a prostaglandins. yogwira ntchito kwambiri (yothandizira kuphatikizira kwa kupatsidwa zinthu za m'magazi), kuchuluka kwa adenosine mu cr ova, blockade ya glycoprotein GP IIb / IIIa receptors. Zotsatira zake, kuphatikiza kwa maselo a m'magazi kumalepheretsa, kukana kwawo kusakanikirana kumachulukitsidwa, katundu wamagazi amayenda bwino, thrombosis imapanikizika, microcirculation imasinthidwa. Chofunikira choletsa kuphatikiza kwa ma cell amwazi chimatheka pa 30 mg. Amawonjezera plasma fibrinolytic ntchito ndikuchepetsa kuchuluka kwa mavitamini a magazi a K omwe amadalira magazi. Uric acid excretion imakhudzidwa mu Mlingo wambiri, chifukwa kupatsanso mphamvu m'matumbo aimpso kumatha kuwonongeka.

Zizindikiro zogwiritsidwa ntchito

pachimake kuphwanya thupi, nyamakazi, pericarditis, Mavalidwe am'mimba, chorea

kufatsa kwapafupifupi ululu (kuphatikiza mutu, mutu, mano, kupweteka kwa nyamakazi, nyamakazi, menalgia, algomenorrhea)

Matenda a msana limodzi ndi ululu (lumbago, sciatica)

kuchuluka kwa thupi kutentha kwa chimfine ndi matenda ena opatsirana ndi kutupa (mwa akulu ndi ana opitilira zaka 15)

Mlingo ndi makonzedwe

Acetylsalicylic acid amatengedwa pakamwa atatha kudya ndi madzi ambiri - madzi, mkaka kapena mchere wamadzi.

Ndi febrile ndi ululu matenda tikulimbikitsidwa kutenga 0,25 - 0,5 g / tsiku (1 / 2-1 tabu.) 3 - 6 pa tsiku. The pakati pakati Mlingo ayenera kukhala osachepera 4 maola. Mlingo umodzi wambiri wa 1 g. Mlingo wambiri watsiku ndi tsiku ndi 3.0 g.

Ngati mukumwa mankhwalawa acetylsalicylic acid kwa masiku 5, ululu wammbuyo kapena kwa masiku atatu malungo apitiliza, muyenera kusiya kulandira chithandizo chamankhwala.

Zotsatira zoyipa

chizungulire, tinnitus, kusamva kwa makutu

NSAID gastropathy: kupweteka kwa epigastric, kutentha pa chifuwa, nseru, kusanza, magazi akulu m'mimba

thrombocytopenia, kuchepa magazi, leukopenia

Reye / Reye syndrome (encephalopathy yomwe ikupita patsogolo: nseru ndi kusanza kosakhazikika, kulephera kupuma, kugona, kukokana, chiwindi chamafuta, hyperammonemia, AST, ALT)

Thupi lawo siligwirizana: laryngeal edema, bronchospasm, urticaria, "aspirin" mphumu, ndi "aspirin" triad (eosinophilic rhinitis, pafupipafupi wammphuno polyposis, hyperplastic sinusitis)

Ndi ntchito yayitali:

interstitial nephritis, prerenal azotemia ndi kuchuluka kwa creatinine m'magazi ndi hypercalcemia, pachimake aimpso kulephera, nephrotic syndrome

matenda a magazi (magazi m'thupi, magazi m'thupi, agranulocytosis, thrombocytopenic purpura)

kuchuluka Zizindikiro za mtima kulephera, edema

kuchuluka kwa aminotransferases m'mwazi.

Zochita zamankhwala osokoneza bongo

Ndi kuphatikiza kwa acetylsalicylic acid ndi kukonzekera kwa valproic acid, cephalosporins kapena anticoagulants, chiopsezo cha magazi chikuwonjezeka. Pogwiritsa ntchito munthawi yomweyo mankhwalawa ndi NSAIDs, zazikulu ndi zoyipa zoyambazo zimakwezedwa.

Kumbuyo kwa mankhwala ndi mankhwalawa, zotsatira zoyipa za methotrexate zimakulitsidwa (mukamamwa mankhwala opitilira 15 mg / sabata - Acetylsalicylic acid imatsutsana).

Ndi munthawi yomweyo kugwiritsa ntchito mankhwala a hypoglycemic - mankhwala a sulfonylurea - pali kuwonjezeka kwa zotsatira za hypoglycemic.

Pogwiritsa ntchito munthawi yomweyo ndi glucocorticosteroids, kumwa mowa, ngozi ya kutulutsa magazi m'mimba imachulukanso.

Mankhwala amachepetsa mphamvu ya spironolactone, furosemide, antihypertgency ndi anti-gout othandizira omwe amalimbikitsa kuphipha kwa uric acid.

Kukhazikitsa antacid pa mankhwala ndi mankhwalawa (makamaka Mlingo woposa 3.0 g kwa akuluakulu) kungayambitse kuchepa kwa khola lalitali m'magazi.

Malangizo apadera

Acetylsalicylic acid imawonjezera vuto la kutaya magazi ngakhale mutamwa mankhwala ochepa komanso kwa masiku angapo mutamwa. Pamaso pa opaleshoni iliyonse, dziwitsani dokotala, dokotala wa opaleshoni, wamankhwala kapena wamano za kumwa acetylsalicylic acid. Masiku 5-7 asana opaleshoni, ndikofunikira kuletsa phwando (kuchepetsa magazi munthawi ya opareshoni ndi nthawi ya postoperative). Pa chithandizo cha nthawi yayitali, tikulimbikitsidwa kuyezetsa magazi pafupipafupi ndikuwunika ndowe za magazi amizimu.

Ndi munthawi yomweyo anticoagulation mankhwala ndi acetylsalicylic acid yaying'ono Mlingo, uric asidi chimbudzi yafupika, amene atha kukhala chifukwa cha gout.

Kugwiritsa ntchito kwa ana Osanenanso mankhwala acetylsalicylic acid wa ana osakwana zaka 15 zokhala ndi matenda opumira kwambiri am'mimba omwe amayamba chifukwa cha matenda opatsirana ndi mavairasi, omwe ali ndi matenda omwe amaperekedwa ndi hyperthermia chifukwa choopsa cha matenda a Reye / Ray syndrome.

Zomwe zimachitika chifukwa cha mankhwalawa amatha kuyendetsa galimoto kapena njira zoopsa

Palibe umboni wotsutsa pa chidwi, pamagetsi ndi pamagetsi.

Bongo

Copusa: chizungulire, kusawona bwino komanso kumva, nseru, kusanza, kupuma kwambiri. Pambuyo pake, pamakhala kukhumudwa kwa chikumbumtima, kupuma, kulephera, acid-base usawa (kupuma kwa alkalosis, ndiye metabolic acidosis), kulephera kwa impso (ARF), kugwedezeka. Kuledzera koopsa ndikotheka kumwa mankhwala a 200 mpaka 500 mg / kg.

Chithandizo: kusanza kapena kupukusa kwam'mimba, gwiritsani ntchito makala, makala. Chithandizo chikuyenera kuchitika mu dipatimenti yapadera.

Tulutsani mawonekedwe ndi ma CD

500 mg mapiritsi

Mapiritsi 10 aikidwa mu contour bezeljakovoj mapangidwe okhala ndi mapepala okhala ndi othandiza polyethylene.

Mabagi 100 a contour bezjacheykovy pamodzi ndi malangizo ofanana ogwiritsira ntchito kuchipatala ndipo zilankhulo za Chirasha zimayikidwa mu bokosi kuchokera pamatoni a katoni (ma CD).

Wogwirizira Sitifiketi Yoyang'anira

Marbiopharm OJSC, Russian Federation

Adilesi ya bungweli yomwe imavomereza zodula kuchokera kwa ogula pamsika wazogulitsa (katundu) ku Republic of Kazakhstan

Russian Federation, 424006, Republic of Mari El, Yoshkar-Ola,

Foni: (8362) 42-03-12, fakisi: (8362) 45-00-00

Pharmacology

Imalepheretsa cycloo oxygenase (COX-1 ndi COX-2) ndipo imalepheretsa njira ya cycloo oxygenase ya arachidonic acid metabolism, imalepheretsa kuphatikizika kwa PG (PGA₂PGD₂, PGF_2alphaPET₁PET₂ ndi ena) ndi thromboxane. Imachepetsa hyperemia, exudation, capillary permeability, hyaluronidase ntchito, imachepetsa mphamvu yamagetsi yotupa poyimitsa kupanga kwa ATP. Zimakhudza malo osiyanasiyananso a thermoregulation ndi sensitivity ululu. Kuchepetsa kwa GHG (makamaka PGE₁ ) pakati pa thermoregulation kumabweretsa kuchepa kwa kutentha kwa thupi chifukwa cha kuchuluka kwa mitsempha ya magazi pakhungu komanso thukuta lomwe likuwonjezeka. Mphamvu ya analgesic imachitika chifukwa cha malo omwe akumva kupweteka, komanso kuphatikizira odana ndi zotupa komanso kuthekera kwa salicylates kuchepetsa zotsatira zoyipa za bradykinin. Kuthetsa kwa Thromboxane₂ kupatsidwa zinthu zam'magazi kumabweretsa kuponderezana kosasinthika, komwe kumachepetsa mitsempha ya m'magazi. Antiplatelet zotsatira zimapitirira kwa masiku 7 pambuyo limodzi. Kafukufuku wowerengeka adawonetsa kuti zopinga zazikuluzikulu za kuphatikiza kwamagazi zimapezeka pamtunda mpaka 30 mg. Kuchulukitsa kwa plasma fibrinolytic ntchito ndikuchepetsa kuchuluka kwa mavitamini obwera chifukwa cha vitamini K (II, VII, IX, X). Zimathandizira kupukusa kwa uric acid, chifukwa kuphatikizika kwake m'matumbo aimpso kumatha kuwonongeka.

Pambuyo pakukonzekera pakamwa, imatenga bwino. Pamaso pa membrane wa enteric (osagwirizana ndi machitidwe a m'mimba ndipo samalola kuyamwa kwa acetylsalicylic acid m'mimba), imayamwa kumtunda kwa matumbo ang'ono. Pa mayamwidwe, amachotsedwapo mwachangu mu khoma lamatumbo ndi chiwindi (deacetylated). Gawo lomwe limalowa ndi hydrolyzed mwachangu kwambiri ndi ma esterases apadera, chifukwa chake, T_1/2 acetylsalicylic acid si zoposa 15-20 mphindi. Zimazungulira mthupi (75-90% chifukwa cha albin) ndipo zimagawidwa mu minofu ngati anion ya salicylic acid. C_max zimatheka pambuyo pafupifupi maola 2. Acetylsalicylic acid kwenikweni sikugwirizana ndi mapuloteni a plasma. Panthawi ya biotransfform, metabolites amapangidwa m'chiwindi chomwe chimapezeka mu minofu yambiri komanso mkodzo. The excretion ya salicylates imachitika makamaka mwachangu secretion mu tubules a impso mu mawonekedwe osasinthika komanso mawonekedwe a metabolites. Kutupa kwa zinthu zosasinthika ndi metabolites zimatengera pH ya mkodzo (ndi mkodzo wamkodzo, ionization wa salicylates umawonjezereka, kubwezeretsanso kwawo kumakulirakulira, ndipo chimbudzi chimakulirakulira).

Kugwiritsa ntchito chinthu Acetylsalicylic acid

IHD, kukhalapo kwa zinthu zingapo zowopsa kwa IHD, vuto losakanizira la myocardial ischemia, osakhazikika angina, infarction ya myocardial (kuti muchepetse kubwereza kwaposachedwa kwa myocardial infarction ndi kufa pambuyo pa myocardial infarction, kubwereza kwakanthawi kwa ubongo kwa ischemia ndi ischemic stroke ya amuna, ma cell a mtima oletsa (kupewa ndi chithandizo cha thromboembolism) , balloon coronary angioplasty ndi kuyikika kwa stent (kuchepetsa chiopsezo cha kubwezeretsa m'mbuyo ndi kuchiritsa kwachiwiri kwa mitsempha yam'mimba), komanso zotupa zosagwirizana ndi luso awapeze (Kawasaki matenda), aortoarteriit (matenda Takayasu), mitral vavu zopindika a mtima ndi matenda fibrillation, mitral vavu prolapse (thromboembolism prophylaxis), kobwereza m'mapapo mwanga embolism, syndrome Dressler a, infarction m'mapapo mwanga, pachimake thrombophlebitis. Thupi la matenda opatsirana komanso kutupa. Ululu matenda ofooka komanso sing'anga mphamvu zosiyanasiyana zoyambira, kuphatikiza thoracic radicular syndrome, lumbago, migraine, mutu, neuralgia, mano, myalgia, arthralgia, algomenorrhea. Mu matenda immunology ndi allergology, amagwiritsidwa ntchito pang'onopang'ono kuchuluka kwa "aspirin" desensitization wopanga nthawi yayitali komanso kupanga mapangidwe olimba a NSAIDs mwa odwala omwe ali ndi mphumu ya "aspirin" ndi "aspirin".

Malinga ndi zomwe zikuwonetsa, rheumatism, rheumatic chorea, nyamakazi, percarditis - pakadali pano amagwiritsidwa ntchito kwambiri.

Mimba komanso kuyamwa

Kugwiritsa ntchito milingo yayikulu ya salicylates m'nthawi yoyamba ya mimba kumalumikizidwa ndi kuchuluka kwa zolakwika za fetal (kufala kwamkati, zolakwika zamtima). Mu trimester yachiwiri yokhudza kubereka, ma salicylates amatha kutumizidwa pokhapokha kuyesa kuwopsa ndi kupindula. Kukhazikitsidwa kwa salicylates mu III trimester ya mimba kumatsutsana.

Ma salicylates ndi ma metabolites awo ochepa amapita mkaka wa m'mawere. Mwadzidzidzi kudya kwa salicylates pa mkaka wa m`mawere sikuyenda limodzi ndi zovuta mu zimachitika mwa mwana ndipo sikutanthauza kuti kuyamwa yoyamwitsa. Komabe, ngati mukugwiritsidwa ntchito kwa nthawi yayitali kapena makonzedwe akulu, kuyamwitsa kuyenera kuyimitsidwa.

Malangizo ogwiritsira ntchito Acetylsalicylic acid, mlingo

Mapiritsi adapangidwira kuti azigwiritsidwa ntchito pakamwa - tikulimbikitsidwa kuti muzidya mukatha kudya mkaka, madzi abwinobwino kapena mchere wamchere.

Mlingo wofanana wa acetylsalicylic acid malinga ndi malangizo omwe angagwiritsidwe ntchito kwa akuluakulu - kuyambira 500 mg mpaka 1 g (mapiritsi a 1-2) mpaka kanayi pa tsiku.

Mlingo umodzi wambiri ndi gramu imodzi (mapiritsi 2).
Mlingo wambiri tsiku lililonse ndi magalamu atatu (mapiritsi 6)

Pofuna kukonza zofunikira za magazi, komanso choletsa kuphatikizika kwa mapulateleti, theka la piritsi la acetylsalicylic acid patsiku limayikidwa miyezi ingapo.

Ndi myocardial infarction komanso kupewa sekondale ya myocardial infarction, tikulimbikitsidwa kutenga 250 mg patsiku.

Kusokonezeka kwakukulu pakumazungulira kwa ubongo ndi ubongo wa thromboembolism kumalimbikitsa kutenga piritsi limodzi ndi kusintha pang'onopang'ono kwa mlingo mpaka mapiritsi awiri a Acetylsalicylic acid patsiku.

Zotsatira zoyipa

Malangizowa amachenjeza za mwayi wokhala ndi zotsatirapo zoyipa mukamapatsa Acetylsalicylic acid:

kupweteka kwa epigastric, nseru, kusanza,
kutsegula m'mimba
chizungulire ndi kufooka
kusowa kwa chakudya
kusawona bwino,
magazi - m'mimba, m'mphuno, gingival, chapamimba,
kusintha kwa chithunzi cha magazi - magazi achepetsa kuchuluka kwa hemoglobin ndi mapulateleti,
zovuta mu chiwindi ndi impso,
kukula kwa pachimake aimpso kulephera,
bronchospasm, mu milandu yayikulu, kukula kwa angioedema ndi anaphylactic mantha.

Contraindication

Acetylsalicylic acid amatsutsana zotsatirazi:

m'mimba,
Asipirin wopambana,
kuchuluka kwa zotupa ndi zotupa zam'mimbamo,
machitidwe ogwiritsa ntchito acetylsalicylic acid ndi ena odana ndi kutupa mu mawonekedwe a urticaria ndi rhinitis,
hemorrhagic diathesis,
hemophilia
hypoprothrombinemia,
matenda oopsa a portal
matenda oopsa, chiwopsezo cha hemorrhagic stroke,
strurified aortic aneurysm,
shuga-6-phosphate dehydrogenase akusowa,
Vitamini K akusowa
aimpso ndi chiwindi kulephera,
Matenda a Reye.

Komanso, mankhwalawa amaphatikizidwa mwa amayi apakati, munthawi ya mkaka wa m`mawere ndi kudziwa kukhudzidwa kwa zigawo zikuluzikulu.

Acetylsalicylic acid sichigwiritsidwa ntchito pochiza ana ndi achinyamata omwe akudwala kapena kuchira ku nthomba ndi fuluwenza, chifukwa kupanga kwa pachimake hepatic encephalopathy ndikotheka.

Bongo

Mankhwala osokoneza bongo a acetisalicylic acid amaphatikizidwa ndi vuto la acid-base ndi electrolyte bwino. Kuchepetsa mseru, kusanza, kupweteka m'dera la epigastric, kuchepa kwa kumva ndi chidwi.

Kuganiza kosagwirizana, chisokonezo, kunjenjemera, kugona, kuchepa kwa madzi amchere, chikomokere, metabolic acidosis, komanso kuphwanya kagayidwe kazakudya zam'thupi zimakhalanso zotheka.

Kuchiza kumakhazikika pakuthamangitsa kuthana kwa mankhwalawo, komanso kufalikira kwa acid-base balance.

Analogs Acetylsalicylic acid, mtengo m'mafakisi

Ngati ndi kotheka, mutha kusintha Acetylsalicylic acid ndi analogue yogwira mankhwala - awa ndi mankhwala:

Mukamasankha analogi, ndikofunikira kumvetsetsa kuti malangizo ogwiritsira ntchito acetylsalicylic acid, mtengo ndi kuwunika kwa mankhwala omwe ali ndi zotsatira zofananira sizikugwira ntchito. Ndikofunikira kupeza upangiri wa dokotala komanso kuti usasinthe popanda mankhwala.

Mtengo muma Russian pharmacies: mapiritsi Acetylsalicylic acid 500mg 10pcs. - kuchokera ku ruble 4 mpaka 9, mapiritsi 20 - kuchokera ku ruble 15 mpaka 21, malinga ndi mafakitale 592.

Pewani kufikira ana pa kutentha kwambiri osapitirira + 25 ° C. Moyo wamafoloko ndi zaka 4. Kugulitsa m'mafakisoni popanda mankhwala.