600 ml / mphindi (10 ml / s) ndi 50 ml / mphindi (0.83 ml / s), motero, chilolezo cha impso

74 ml / mphindi (1.23 ml / s) ndi 26 ml / mphindi (0.43 ml / s), motsatana. T_1/2 (theka-moyo) wa losartan - 2 hours, metabolite EXP-3174 - maola 6.9 Pafupifupi 58% ya mankhwalawa amachotsedwa ndi bile, mpaka 35% - ndi impso.

Makhalidwe a Pharmacokinetic a hydrochlorothiazide:

• mayamwidwe ndikugawa: mayamwidwe pambuyo pakamwa pakamwa kuchokera pa 60 mpaka 80%. C_max m'magazi am'madzi mumatha maola 1-5. Mpaka 64% ya zinthu zomwe zimamangidwa kumapuloteni a plasma,
• kagayidwe ndi zotupa: osati zimapukusidwa, zotulutsidwa ndi impso mwachangu, T_1/2 kuyambira maola 5 mpaka 15

Zizindikiro zogwiritsidwa ntchito

Malinga ndi malangizo, a Lorist N amalimbikitsidwa pochiza matenda oopsa mwa odwala omwe akuwonetsedwa ngati akuphatikiza mankhwala.

Mankhwalawa adapangidwanso kuti achepetse chiopsezo cha matenda amtima komanso kufa kwa odwala omwe ali ndi matenda oopsa ndipo amachepetsa mphamvu yamitsempha yamagazi.

Kodi madotolo aku China ati chiyani pa matenda oopsa

Ndakhala ndikuchiza matenda oopsa kwa zaka zambiri. Malinga ndi ziwerengero, mu 89% ya milandu, matenda oopsa amachititsa munthu kugunda kwamtima kapena kugunda kwam'magazi ndipo munthu akafa. Pafupifupi magawo awiri mwa atatu a odwala tsopano amafa zaka 5 zoyambirira za matendawa.

Mfundo yotsatirayi - ndikotheka komanso kofunikira kuti muchepetse kupanikizika, koma izi sizichiritsa matendawa palokha. Mankhwala okhawo omwe samasemphana ndi mfundo zamankhwala achi China ndipo amagwiritsidwa ntchito ndi akatswiri otchuka a mtima kuchiritsa matenda oopsa ndi Hyperten. Mankhwalawa amakhudza zomwe zimayambitsa matendawa, zomwe zimapangitsa kuti athetseretu matenda oopsa. Kuphatikiza apo, pansi pa pulogalamu ya feduro, aliyense wokhala ku Russian Federation akhoza kulandira ZAULERE .

Mankhwala Lorista N ndi Lorista ND khalani ndi zofananira zomwe mungagwiritse ntchito:

• kuchepetsa chiopsezo matenda amtima,
• Kuchepetsa imfa mu odwala ndi lamanzere yamitsempha yamagazi hypertrophy ndi ochepa matenda oopsa,
• ochepa matenda oopsa (kuphatikiza mankhwala).

Mankhwala onse awiriwa sayenera kugwiritsidwa ntchito pazinthu zotsatirazi:

• anuria,
• kusocha mkanda,
• Hyperkalemia,
• hypokalemia chotsatsira,
• aimpso kapena chiwindi ntchito.
• galactosemia,
• kusowa kwamadzi,
• ochepa hypotension,
• mimba
• shuga kapena galactose malabsorption syndrome,
• nyere
• kukhudzika kwa chinthu chilichonse,
• osakwana zaka 18.

Gwiritsani ntchito mosamala mukamachita:

• matenda ashuga,
• zamatsenga aimpso mtsempha wamagazi,
• kuphwanya magazi-electrolyte bwino magazi (hypomagnesemia, hypochloremic alkalosis, hyponatremia, hypokalemia),
• matenda a impso stenosis,
• zamagazi matenda
• Hyperuricemia,
• mbiri yakaliyonse
• hypercalcemia,
• gout,
• mphumu ya bronchial,
• nthawi yomweyo ndi NSAIDs.

Zotsatira zoyipa zomwe zimachitika chifukwa cha kumwa mankhwalawa:

• chizungulire (Zosagwirizana ndi zachikhalidwe), kusowa tulo, migrainemutu, kutopa,
• palpitations, okhudzana ndi orthostatic hypotension, tachycardiawoopsa - vasculitis,
• chifuwa, kutupira kwa mphuno, pharyngitismatenda opumira (zigawo zapamwamba),
• nseru, kupweteka m'mimba, kutsegula m'mimbakusanza dyspepsiaNthawi zina, chiwindi, kuchuluka kwa chiwindi michere, bilirubin, chiwindi ntchito.
• kupweteka kumbuyo arthralgia,myalgia,
• Shenlein-Genoch wofiirira, kuchepa magazi,
• kufooka, kupweteka pachifuwa, astheniazotumphukira edema,
• kuyabwa, kusintha kwa anaphylactic, urticariaangioedema.

Kumwa mankhwalawa kumakhudzanso zizindikiro zasayansi: Hyperkalemia, kuchuluka kwa creatinine, urea, kuchuluka kwa hematocrit ndi hemoglobin.

Malangizo ogwiritsira ntchito Lorista N (Njira ndi Mlingo)

Mankhwalawa amapangidwira pakamwa. Mwina kuphatikiza ndi mankhwala ena omwe ali ndi antihypertensive effect. Kumwa mankhwalawa sikudalira chakudya.

At ochepa matenda oopsa osachepera mlingo zotchulidwa - piritsi 1. Pambuyo pa masabata atatu, zotsatira zabwino kwambiri zimakhala. Kuti mukwaniritse bwino, ndikofunikira kumwa mapiritsi awiri kamodzi patsiku, omwe ndi mlingo waukulu.

Kwa odwala ndi bcc yochepetsedwa muyenera kumwa 25 mg wa osowa patsiku. Ngati kuchepa kwa BCC kudachitika pamene mukumwa mitundu yayikulu yolembera, ndiye kuti musanayambe chithandizo ndi Lorista N, ndikofunikira kusiya kukodzetsa.

Mlingo woyambirira sufuna kukonzanso odwala omwe ali pa dialysis kuvutika kulephera kwa aimpso (wapakati) ndi odwala okalamba(woposa zaka 65).

Mlingo wa tsiku ndi tsiku wa 50 mg wa losartan amathandizidwa kuti achepetse chiopsezo cha matenda amtima komanso kufa kwa odwala omwe amapezeka kuti ali ndi vuto lamanzere lamitsempha yamagazi kapena matenda oopsa. Ngati sizinali zotheka kuchepetsa kukakamiza mutatenga 50 mg, ndiye kuti muyenera kuphatikiza losartan ndi hydrochlorothiazide (12.5 mg). Ngati ndi kotheka, losartan imatha kuwonjezeka mpaka 100 mg popanda kusintha mtundu wa hydrochlorothiazide. Pazipita tsiku lililonse mankhwala sayenera kupitirira kamodzi mapiritsi 2.

Malangizo ogwiritsira ntchito Lorista ND: Mankhwalawa amadziwitsidwa pokhapokha ngati wodwala atamwa Lorista N. Mankhwala a Lorista ND amatengedwa chimodzimodzi.

Bongo losartan ili ndi zizindikiro zotsatirazi: kuchepa kwakukulu kwa kupanikizika, bradycardia, tachycardia. Ngati mankhwala osokoneza bongo apezeka, mankhwalawa akulimbikitsidwa: chithandizo chamankhwala, mokakamizidwa diuresis. Hemodialysis pankhaniyi siyothandiza.

Pankhani ya bongo hydrochlorothiazide Zizindikiro zingachitike: hypochloremia, hypokalemia, hyponatremia. Pankhaniyi, chithandizo chamankhwala ndi mankhwala.

Matenda ofunikira kwambiri a losartan ndi digoxin, phenobarbital, hydrochlorothiazide, ketoconazolomvarfarin, erythromycin ndi cimetidine osadziwika.

Mlingo wa metabolite yogwira umatsika mukamamwa ndi losartan rifampicin ndi fukuchiyama. Komabe, kulumikizana koteroko sikunaphunziridwe kuchipatala.

Hyperkalemia zitha kuchitika chifukwa cha kuphatikiza kwa potaziyamu wotsekemera m'matumbo (kopambana, Ndipironolactone, amiloride), mchere wam potaziyamu kapena zowonjezera zam potaziyamu.

Mphamvu ya losartan itha kuchepetsedwa chifukwa chotenga NSAIDs ndi kusankha COX-2 zoletsa.

Phwando indomethacin zingayambitse kuchepa kwa hypotensive zotsatira lazortana.

Ethanoli, mankhwala osokoneza bongo ndi barbiturates akaphatikizidwa ndi hydrochlorothiazide, amatha kuyambitsa hypotension ya orthostatic.

Kutenga nthawi yomweyo othandizira a hypoglycemic (kuphatikiza insulin) ingafune kusintha kwa mlingo.

Chowonjezera chikhoza kuchitika mukaphatikiza chithandizo ndi ena antihypertensive othandizira.

Kusokoneza mayamwidwe a hydrochlorothiazide amatha mankhwala osokoneza bongo monga colestipol kapena colestyramine.

Hydrochlorothiazide zitha kupititsa patsogolo mphamvu zamagulu opuma minofu (tudocurarin).

Mphamvu za natriuretic, hypotensive, ndi diuretic za hydrochlorothiazide zitha kuchepa chifukwa chogwiritsa ntchito NSAIDs(kuphatikiza ma COX-2 zoletsa).

Zotsatira za labotale za ntchito ya parathyroid zitha kupotozedwa chifukwa cha hydrochlorothiazide pa calcium metabolism.

Mankhwala amagulitsidwa kokha ndi mankhwala.

Mankhwalawa amayenera kusungidwa m'malo amdima, osakhala chinyezi. Kutentha kwambiri ndi 30 ° C.

Kuphatikiza komwe kungachitike ndi mankhwala ena a antihypertensive.

Mlingo woyambirira wa odwala okalamba sunasinthidwe mwachindunji.

Hydrochlorothiazide ikhoza kuchuluka ochepa hypotension ndi kuswa madzi-electrolyte bwino. Ndizothekanso kulekerera glucose, kuchepa kwamatumbo a calcium, komwe kumapangitsa kuti magazi a calcium azikhala ochepa.

Kutenga mankhwala II kapena Wachitatu trimester pa mimba zimayambitsa imfa ya fetal. Mankhwalawa ayenera kusiyidwa ngati pakachitika mimba. Mwana wakhanda kapena mwana wosabadwa akhoza kuoneka jaundicemayi thrombocytopenia.

Kumwa mankhwalawa kwa odwala ambiri sikuwononga kuthekera kochita ntchito zofunika. Komabe, odwala ena kumayambiriro kwa chithandizo amawona kuchepa kwakukulu kwa kukakamiza, chizungulire. Musanayambe ntchito yotere, ndikofunikira kuyesa kuzindikira mutatha kumwa mankhwalawo.

Zofanizira za Lorista N zikuphatikiza: angizar kuphatikiza, mbalamear forte, mogwirizana, Lozap Plus, chivundikiro, nostasartan n, tozaar-g.

Zofanizira zonse pamwambazi zimagwiranso ntchito pa njira ya Lorista ND.

Chiwerengero chapakati cha mankhwala ndi 4,5 mfundo (kuchokera pa 5). Ogula amazindikira mphamvu ya mankhwalawo, mphamvu yake yofatsa. Zina mwa zolephera ndizofunikira kutenga tsiku lililonse ndikuwonetsa zovuta.

Maganizo abwino ochokera kwa madokotala okhudzana ndi mankhwalawa akuti amagwira ntchito bwino. Komabe, akatswiri amadziwa kuti ndikofunikira kumwa mosamalitsa Mlingo womwe madokotala amatsimikiza kuti achepetse zovuta zoyambira.

Ndemanga pa Lorist ND makonda ndemanga za Loriste N.

Mtengo Lorists ND ku Russia amakhala ndi ma ruble 350, ku Ukraine - 112 UAH.

Mtengo wa Lorist N ku Russia - ma ruble 214, ku Ukraine - 114 UAH.

LAPANI ZOTSATIRA!
Zambiri pamankhwala omwe ali pamalowo ndizokhudza zonse, zomwe zimatengedwa kuchokera kwa anthu ndipo sizingagwiritsidwe ntchito ngati lingaliro la kugwiritsa ntchito mankhwalawa munthawi ya chithandizo. Musanagwiritse ntchito mankhwala a Lorista N / ND, onetsetsani kuti mwawonana ndi dokotala.

Fotokozani

Matenda a mtima komanso mikwingwirima ndizomwe zimayambitsa pafupifupi 70% ya imfa zonse padziko lapansi. Anthu asanu ndi awiri mwa anthu khumi amafa chifukwa chotseka mitsempha ya mtima kapena ubongo.

Choyipa chachikulu ndikuti anthu ambiri saganiza kuti ali ndi matenda oopsa. Ndipo amaphonya mwayi wokonza kena kake, kumadzipangitsa kufa.

• Mutu
• Zosangalatsa pamtima
• Madontho akuda patsogolo pa maso (ntchentche)
• Kupanda chidwi, kusakwiya, kugona
• Masomphenya opanda pake
• Kutukwana
• Kutopa kwambiri
• Kutupa kwa nkhope
• Kunenepa komanso kuzizira kwa zala
• Kupanikizika kumapitilira

Ngakhale chimodzi mwazizindikirozi chikuyenera kukupangitsani kuganiza. Ndipo ngati pali awiri, musazengereze - muli ndi matenda oopsa.

Momwe mungathanirane ndi matenda oopsa pakakhala kuchuluka kwa mankhwala omwe amawononga ndalama zambiri?

Mankhwala ambiri sangachite bwino, ndipo ena amatha kupweteketsa! Pakadali pano, mankhwala okhawo omwe amavomerezeka ndi Unduna wa Zaumoyo pa matenda oopsa ndi Hyperten.

Mpaka February 26th. Institute of Cardiology, pamodzi ndi Unduna wa Zaumoyo, ukuchita pulogalamu " wopanda matenda oopsa"Momwe Hyperten amapezeka ZAULERE , onse okhala mumzinda ndi dera!

Sindikudziwa, kwa ine, mankhwala ambiri ali zinyalala kwathunthu, kuwononga ndalama.Kodi mungadziwe momwe ndayesera kale zonse .. Hyperten yekha amathandizika (mwa njira, malinga ndi pulogalamu yapaderayo, mutha kuipeza pafupifupi yaulere). Ndinkamwera kwa milungu inayi, nditatha sabata yoyamba kumwa, thanzi langa linakhala bwino. Miyezi 4 yadutsa kuyambira pamenepo, kupanikizika ndizabwinobwino, ndipo sindikukumbukira za matenda oopsa! Zimatanthawuza kuti nthawi zina ndimamwa kachiwiri kwa masiku 2-3, pofuna kupewa. Ndipo ndidaphunzira za iye mwangozi, kuchokera m'nkhaniyi ..

Lorista N / N

Kufotokozera kogwirizana ndi 07.05.2014

• Dzina lachi Latin: Lorista H, Lorista HD
• Code ya ATX: C09DA01
• Chithandizo: Losartan, Hydrochlorothiazide (Hydrochlorothiazide>

Piritsi limodzi lamankhwala Lorista N ili ndi:

• 50 mg losartan potaziyamu,
• 12,5 mg hydrochlorothiazide,
• magnesium stearate, MCC, lactose monohydrate, pregelatinized wowuma.

Mapiritsi osokoneza bongo Lorista ND muli:

• 100 mg losartan potaziyamu,
• 25 mg nidrohlortiziada,
• magnesium stearate, MCC, lactose monohydrate, pregelatinized wowuma.

Chipolopolocho ndi hypromelloseUtoto wa quinoline (wachikasu), talc, macrogol 4000 ndi titanium dioxide (E171).

Contraindication

Mankhwala onse awiriwa sayenera kugwiritsidwa ntchito pazinthu zotsatirazi:

• anuria,
• kusocha mkanda,
• Hyperkalemia,
• hypokalemia chotsatsira,
• aimpso kapena chiwindi ntchito.
• galactosemia,
• kusowa kwamadzi,
• ochepa hypotension,
• mimba
• shuga kapena galactose malabsorption syndrome,
• nyere
• kukhudzika kwa chinthu chilichonse,
• osakwana zaka 18.

Gwiritsani ntchito mosamala mukamachita:

• matenda ashuga,
• zamatsenga aimpso mtsempha wamagazi,
• kuphwanya magazi-electrolyte bwino magazi (hypomagnesemia, hypochloremic alkalosis, hyponatremia, hypokalemia),
• matenda a impso stenosis,
• zamagazi matenda
• Hyperuricemia,
• mbiri yakaliyonse
• hypercalcemia,
• gout,
• mphumu ya bronchial,
• nthawi yomweyo ndi NSAIDs.

Zotsatira zoyipa

Zotsatira zoyipa zomwe zimachitika chifukwa cha kumwa mankhwalawa:

• chizungulire (Zosagwirizana ndi zachikhalidwe), kusowa tulo, migrainemutu, kutopa,
• palpitations, okhudzana ndi orthostatic hypotension, tachycardiawoopsa - vasculitis,
• chifuwa, kutupira kwa mphuno, pharyngitismatenda opumira (zigawo zapamwamba),
• nseru, kupweteka m'mimba, kutsegula m'mimbakusanza dyspepsiaNthawi zina, chiwindi, kuchuluka kwa chiwindi michere, bilirubin, chiwindi ntchito.
• kupweteka kumbuyo arthralgia,myalgia,
• Shenlein-Genoch wofiirira, kuchepa magazi,
• kufooka, kupweteka pachifuwa, astheniazotumphukira edema,
• kuyabwa, kusintha kwa anaphylactic, urticariaangioedema.

Kumwa mankhwalawa kumakhudzanso zizindikiro zasayansi: Hyperkalemia, kuchuluka kwa creatinine, urea, kuchuluka kwa hematocrit ndi hemoglobin.

Bongo

Bongo losartan ili ndi zizindikiro zotsatirazi: kuchepa kwakukulu kwa kupanikizika, bradycardia, tachycardia. Ngati mankhwala osokoneza bongo apezeka, mankhwalawa akulimbikitsidwa: chithandizo chamankhwala, mokakamizidwa diuresis. Hemodialysis pankhaniyi siyothandiza.

Pankhani ya bongo hydrochlorothiazide Zizindikiro zingachitike: hypochloremia, hypokalemia, hyponatremia. Pankhaniyi, chithandizo chamankhwala ndi mankhwala.

Kuchita

Matenda ofunikira kwambiri a losartan ndi digoxin, phenobarbital, hydrochlorothiazide, ketoconazolomvarfarin, erythromycin ndi cimetidine osadziwika.

Mlingo wa metabolite yogwira umatsika mukamamwa ndi losartan rifampicin ndi fukuchiyama. Komabe, kulumikizana koteroko sikunaphunziridwe kuchipatala.

Hyperkalemia zitha kuchitika chifukwa cha kuphatikiza kwa potaziyamu wotsekemera m'matumbo (kopambana, Ndipironolactone, amiloride), mchere wam potaziyamu kapena zowonjezera zam potaziyamu.

Mphamvu ya losartan itha kuchepetsedwa chifukwa chotenga NSAIDs ndi kusankha COX-2 zoletsa.

Phwando indomethacin zingayambitse kuchepa kwa hypotensive zotsatira lazortana.

Ethanoli, mankhwala osokoneza bongo ndi barbiturates akaphatikizidwa ndi hydrochlorothiazide, amatha kuyambitsa hypotension ya orthostatic.

Kutenga nthawi yomweyo othandizira a hypoglycemic (kuphatikiza insulin) ingafune kusintha kwa mlingo.

Chowonjezera chikhoza kuchitika mukaphatikiza chithandizo ndi ena antihypertensive othandizira.

Kusokoneza mayamwidwe a hydrochlorothiazide amatha mankhwala osokoneza bongo monga colestipol kapena colestyramine.

Hydrochlorothiazide zitha kupititsa patsogolo mphamvu zamagulu opuma minofu (tudocurarin).

Mphamvu za natriuretic, hypotensive, ndi diuretic za hydrochlorothiazide zitha kuchepa chifukwa chogwiritsa ntchito NSAIDs(kuphatikiza ma COX-2 zoletsa).

Zotsatira za labotale za ntchito ya parathyroid zitha kupotozedwa chifukwa cha hydrochlorothiazide pa calcium metabolism.

Malangizo apadera

Kuphatikiza komwe kungachitike ndi mankhwala ena a antihypertensive.

Mlingo woyambirira wa odwala okalamba sunasinthidwe mwachindunji.

Hydrochlorothiazide ikhoza kuchuluka ochepa hypotension ndi kuswa madzi-electrolyte bwino. Ndizothekanso kulekerera glucose, kuchepa kwamatumbo a calcium, komwe kumapangitsa kuti magazi a calcium azikhala ochepa.

Kutenga mankhwala II kapena Wachitatu trimester pa mimba zimayambitsa imfa ya fetal. Mankhwalawa ayenera kusiyidwa ngati pakachitika mimba. Mwana wakhanda kapena mwana wosabadwa akhoza kuoneka jaundicemayi thrombocytopenia.

Kumwa mankhwalawa kwa odwala ambiri sikuwononga kuthekera kochita ntchito zofunika. Komabe, odwala ena kumayambiriro kwa chithandizo amawona kuchepa kwakukulu kwa kukakamiza, chizungulire. Musanayambe ntchito yotere, ndikofunikira kuyesa kuzindikira mutatha kumwa mankhwalawo.

Zofanizira za Lorista N zikuphatikiza: angizar kuphatikiza, mbalamear forte,mogwirizana, Lozap Plus, chivundikiro, nostasartan n, tozaar-g.

Zofanizira zonse pamwambazi zimagwiranso ntchito pa njira ya Lorista ND.

Ndemanga za Lorista N

Chiwerengero chapakati cha mankhwala ndi 4,5 mfundo (kuchokera pa 5). Ogula amazindikira mphamvu ya mankhwalawo, mphamvu yake yofatsa. Zina mwa zolephera ndizofunikira kutenga tsiku lililonse ndikuwonetsa zovuta.

Maganizo abwino ochokera kwa madokotala okhudzana ndi mankhwalawa akuti amagwira ntchito bwino. Komabe, akatswiri amadziwa kuti ndikofunikira kumwa mosamalitsa Mlingo womwe madokotala amatsimikiza kuti achepetse zovuta zoyambira.

Ndemanga pa Lorist ND makonda ndemanga za Loriste N.

Kodi pali kusiyana kotani pakati pa Lorista ndi Lorista N?

Kusiyana kwakukulu pakati pa zida ziwiri zamankhwala izi kapangidwe kawo. Chifukwa chake, ngati mwapadera mtundu wa mankhwalawa, losartan imaperekedwa, ndipo cellulose, wowuma chimanga, maginito otentha, silicon dioxide ndi zina zotere amagwiritsidwa ntchito ngati zokopa, ndiye mu nkhani ya Lorista N, zonsezi pamwambapa zimathandizidwanso ndi hydrochlorothiazide. Wotsirizirayi ndi mankhwala omwe amachepetsa kwambiri kubwezeretsanso kwa Na + pamlingo wa gawo la cortical. Inde, zake zimachepa, ndipo nthawi zina zimayima ngati kuchuluka kwa kusefera kwamadzi kumatsika mpaka 30 ml / min.

Ngati timalankhula za odwala omwe ali ndi matenda a shuga insipidus, ndiye chida ichi chiziwapatsa antidiuretic zotsatirazofunika kuti muchepetse kuchuluka kwa mkodzo, komanso kuwonjezera kuchuluka kwake. Pankhani ya mankhwala "LoristaN", malangizo ena apadera amaperekedwa. Chofunika kwambiri kwa iwo ndikusowa kwa kufunika kosankha koyamba kwa odwala okalamba. Komanso, musanagule Lorista N, muyenera kukumbukiranso kuti ilinso ndi lactose, yomwe singathe kufotokozedwa molingana ndi odwala omwe adapezeka ndi galactosemia.

Pofotokozera mwachidule zomwe zili pamwambazi, tikuwona kuti ndizofunikira kuzindikira zingapo, makamaka zofunika:

1. Choyamba, mankhwalawa amasiyana mu nyimbo zawo. Mwachitsanzo, mwachitsanzo, mu nkhani ya Lorista N, gawo ngati hydrochlorothiazide limaperekedwa. Mwakutero, kupezeka kwake kumawonjezera phindu mankhwalawa chifukwa amachepetsa Na + reabsorption.
2. Mtengo wa mankhwalawa ndiwosiyana. Chifukwa chake, kuti Lorista yokhazikika, mupereka ma ruble 130, ndiye kuti mukagula Lorista N, muyenera kupereka ma ruble 230.

Kupanga ndi pharmacological kanthu

Mankhwala ndi a gulu la antihypertensive mankhwala. Zomwe zimagwiritsidwa ntchito ndi losartan. Izi zimapangitsa ntchito ya renin ndikuchepetsa kuchuluka kwa aldosterone. Izi zimathandizira kuchepetsa nkhawa pamakoma amitsempha yamagazi ndi mtima.

Kuphatikiza pa losartan, mawonekedwe a mankhwalawa akuphatikizapo:

• cellulose
• olimba ndi magnesium,
• cellulose
• hypopellose,
• kukhuthala
• talcum ufa
• silika
• hypopellose,
• titanium dioxide
• propylene glycol.

Gawo lolimbikira limatengeka mosavuta, zomwe zimachitika m'magawo am'mimba, kutuluka kwake kumachitika ndi impso. Pang'onopang'ono, limasiya thupi ndi bile.

Kodi mankhwala a Lorista ndi a Lorista N amagwira ntchito bwanji?

Lorista ndi wa gulu la angiotensin II receptor antagonists.

Lorista ndi wa gulu la angiotensin II receptor antagonists.

Yogwira ntchito ya mankhwala ndi potaziyamu losartan. Wopanga amapereka ma 4 mlingo:

Izi zimasankha maselo a AT1 mosasokoneza, osakhudza ma receptor a mahomoni ena omwe amakhudzidwa ndi kayendetsedwe ka kayendedwe ka mtima. Chifukwa cha izi, mankhwalawa amalepheretsa kuchuluka kwa magazi a systolic ndi diastolic chifukwa cha kulowetsedwa kwa angiotensin:

• 85% pa nthawi yayitali ya plasma ndende yafika ola limodzi mutatha kumwa 100 mg,
• 26-39% pambuyo maola 24 kuchokera nthawi yoyendetsa.

Kuphatikiza kwa matenda oopsa, umboni wa kugwiritsa ntchito mankhwalawa ndi:

• Kulephera kwamtima kwakanthawi (ngati chithandizo ndi ACE zoletsa sichitha),
• kufunika kuchepetsa kuchepa kwa impso kwa odwala omwe ali ndi matenda a shuga a 2.

Kutenga mankhwalawa chifukwa cha matenda oopsa kungachepetse kufa kwa stroke.
Lorista amagwiritsidwa ntchito pochita matenda oopsa.
Lorista amagwiritsidwa ntchito chifukwa cha matenda olephera a mtima.
Kutenga mankhwalawa kwa matenda oopsa kungachepetse kufa kwa vuto la mtima.
Lorista amagwiritsidwa ntchito ngati kuli kofunikira kuti achedwetse kuchepa kwa aimpso kwa odwala omwe ali ndi matenda ashuga a 2.

Kutenga mankhwalawa kwa matenda oopsa kungachepetse kufa kwa vuto la mtima kapena sitiroko pakati pa odwala omwe ali ndi matenda amtima, makamaka kumanzere kwamitsempha yamagazi.

The mankhwala a Lorista N akuphatikiza:

• hydrochlorothiazide - 12,5 mg,
• potaziyamu losartan - 50 mg.

Ndi mankhwala ophatikiza antihypertensive.

Kugwiritsa ntchito zinthuzi palimodzi kumabweretsa zotsatira zotchuka kuposa kugwiritsa ntchito mosiyana.

Hydrochlorothiazide ali m'gulu la thiazide okodzetsa, ali ndi zotsatirazi:

• kumawonjezera ntchito ya renin ndi zomwe angiotesin II amapezeka m'magazi,
• imalimbikitsa kumasulidwa kwa aldosterone,
• amachepetsa kubwezeretsanso kwa sodium ndi kuchuluka kwa potaziyamu mu seramu yamagazi.

Kuphatikiza kwa mankhwalawa kumapereka kuchepa kwakukulu kwa kuthamanga kwa magazi, osakhudza kugunda kwa mtima.

Kuphatikiza kwa mankhwalawa kumapereka kuchepa kwakukulu kwa kuthamanga kwa magazi, osakhudza kugunda kwa mtima.

Achire zotsatira za mlingo amapezeka 2 mawola utakhazikitsa ndi kumatenga maola 24.

Mankhwala omwe amawaganizira ali ndi zovuta zingapo, mwa iwo:

• zovuta zamanjenje: kusokonezeka kwa tulo, kupweteka mutu, kusokonezeka kwa malingaliro, ndi zina zambiri,
• kutentha kwa mtima
• aimpso kuwonongeka (kuphatikizapo pachimake aimpso kulephera),
• zosokoneza mu kagayidwe kazinthu zamagetsi,
• kuchuluka kwa seramu cholesterol ndi triglycerides,
• Zizindikiro zam'maso
• mawonetseredwe osiyanasiyana amitundu yosiyanasiyana,
• conjunctivitis ndi kuwonongeka kwa mawonekedwe,
• kutsokomola ndi chifuwa chammphuno,
• kuphwanya kugonana.

Mankhwala omwe amafunsidwa ali ndi zovuta zambiri, pakati pawo kugona mosokoneza.
Mankhwalawa ali ndi zotsatirapo zingapo zoyipa, ndipo mwa iwo mumakhala mavuto ena.
Mankhwala omwe amafunsidwa ali ndi zotsatira zoyipa zingapo, mwa iwo mumagwira ntchito yaimpso.
Mankhwala omwe amafunsidwa ali ndi zovuta zingapo, pakati pawo ndikuphwanya mzere wamtima.
Mankhwala omwe amawonedwa amakhala ndi zovuta zambiri, pakati pawo zovuta za dyspeptic.
Mankhwala omwe amawaganizira amakhala ndi zovuta zambiri, pakati pawo conjunctivitis.
Mankhwala omwe amafunsidwa ali ndi mavuto ambiri, kuphatikizapo kutsokomola.

Chifukwa chakuti kumwa mankhwala okhala ndi hydrochlorothiazide kumatha kupangitsa kuti matenda a impso asungike, ayenera kuphatikizidwa ndi Metformin mosamala. Izi zingayambitse kukula kwa lactic acidosis.

Muyenera kudziwa kuti mankhwalawa amaperekedwa kwa odwala osaposa zaka 18, panthawi yoyembekezera komanso mkaka wa m'mawere, komanso ndi matenda otsatirawa:

• hypotension
• Hyperkalemia
• kusowa kwamadzi
• malabsorption wa shuga.

Mankhwala amatengedwa pakamwa 1 nthawi / tsiku, mosasamala chakudya. Mapiritsi ayenera kutsukidwa ndi madzi ambiri. Kuphatikiza kwa mankhwalawa ndi mankhwala ena a antihypertensive ndikovomerezeka. Pogwiritsa ntchito munthawi yomweyo, zotsatira zowonjezera zimawonedwa.

Kuyerekezera Mankhwala

Ngakhale pali kuchuluka kwakukulu kwa mawonekedwe omwe amaphatikiza mankhwalawa, adokotala okha ndi omwe amatha kudziwa omwe angasankhe kulandira chithandizo, kutengera zosowa za wodwalayo. Sizovomerezeka kuti m'malo mwamankhwala ena muthane ndi ena.

Mankhwalawa amatsutsana mu hypotension.
Mankhwalawa amatsutsana mu hyperkalemia.
Mankhwalawa ali contraindised mu madzi osowa madzi.
Mankhwalawa amatsutsana panthawi yomwe ali ndi pakati.
Mankhwalawa amatsutsana panthawi ya mkaka wa m`mawere.
Mankhwalawa amaphatikizidwa kwa odwala osakwana zaka 18.

Mankhwalawa ali ndi zinthu zodziwika bwino izi:

• Zotsatira zake chifukwa chomwa mankhwalawo ndi kuchepetsa kuthamanga kwa magazi,
• kupezeka kwa potaziyamu mu losartan,
• mawonekedwe a mankhwalawa.

Kodi pali kusiyana kotani?

Kusiyanitsa kwakukulu pakati pa mankhwalawa kumawonekera poyerekeza nyimbo. Igona pamaso pa Lorist N pazinthu zina zowonjezera. Izi zimawonekera mu mtundu wa momwe mankhwalawo amathandizira (amawonjezera okodzetsa), ndi mtengo wake. Chofunikanso ndichakuti mankhwalawa amapereka mankhwalawa 4.

Lorista N, mosiyana ndi Lorista, sagwiritsidwa ntchito pochotsa kukhumudwa kwa mtima komanso kuchepetsa kufalikira kwa aimpso odwala matenda ashuga.

Zomwe zimakhala zotsika mtengo

Mtengo wa mankhwala a Lorista zimatengera muyeso wa zomwe zimagwiritsidwa ntchito. Webusayiti yachipatala chodziwika bwino ku Russia imapereka mapiritsi 30 pamitengo yotsatirayi:

• 12,5 mg - 145.6 ma ruble,
• 25 mg - 159 ma ruble,
• 50 mg - 169 ma ruble,
• 100 mg - 302 rub.

Pomwe mtengo wa Lorista N ndi ma ruble 265. Titha kuwona pamenepa kuti ndi mulingo wofanana wa losartan potaziyamu, kukonzekera kophatikizidwa kumawononga ndalama zambiri chifukwa kukhalapo kwa chinthu china chomwe chikugwirika.

Zomwe zili bwino - Lorista kapena Lorista N

Lorista ali ndi zabwino zingapo zomwe sizingatheke pompangidwe:

• kuthekera popereka mankhwala osinthika,
• zoyipa zochepa chifukwa chogwiritsa ntchito chimodzi,
• mtengo wotsika.

Komabe, izi sizitanthauza kuti zokonda ziyenera kupatsidwadi mtundu uwu wa mankhwalawo. Ngati wodwala alandila chithandizo chamankhwala, kuikidwa kwa Lorista N kudzakhala kovomerezeka.

Lorista - mankhwala ochepetsa mphamvu

Ndemanga za madotolo za Lorista ndi Lorista N

Alexander, wazaka 38, wowerenga zamtima, ku Moscow: "Ndimaona ngati Lorista ndi mankhwala amakono, ogwiritsira ntchito bwino matenda oopsa a digiri ya I ndi II"

Elizaveta, wazaka 42, katswiri wa zamtima, Novosibirsk: "Ndimaona kuti potaziyamu wa losartan samatha kugwira ntchito monotherapy. Nthawi zonse ndimapereka mankhwala osakanikirana ndi othandizira okhudzana ndi calcium kapena okodzetsa. M'machitidwe anga, nthawi zambiri ndimagwiritsa ntchito mankhwala ophatikizira a Lorista N".

Ndemanga za Odwala

Azat, wazaka 54, Ufa: "Ndakhala ndikumutenga Lorista m'mawa mwezi wathunthu. Zotsatira zake zochizira zimatha tsiku lonse. Ndipo ngakhale m'mawa wotsatira, asanamwe mapiritsi, kupanikizika kumadalirabe."

Marina, wazaka 50, Kazan: "Ndimaona kuti a Lorista N ndiwothandiza kwambiri kuti hydrochlorothiazide yomwe adamupanga, pakuchotsa kutupa bwino, sikuwonjezera kukodzanso."

Vladislav, wazaka 60, wa ku St.

Pa mimba ndi mkaka wa m`mawere

Zokhudza mphamvu za osakhazikika pamimba ndi kulera kwa fetus sizinaphunzire. Chifukwa chake, mimba ikachitika, mankhwala ayenera kusokonezedwa. Mankhwalawa angakhudze mtundu wa mkaka wa m'mawere, chifukwa chake simuyenera kuugwiritsa ntchito poyamwitsa.

Odwala a Lorista omwe ali ndi zaka zosakwana zambiri amaletsedwa, chifukwa deta yachitetezo chake ndi kuwakwanira sizikupezeka.

Zotsatira zoyipa

Mankhwalawa amalekeredwa bwino ndipo nthawi zambiri samayambitsa mavuto. Koma zolengedwa zamunthu ndizosiyana, kotero momwe zimachitikira kwa losartan zimatha kukhala zosiyana. Pamndandanda wazotsatira zoyipa:

• chizungulire
• mutu
• kusowa tulo
• tachycardia
• kutsokomola
• kutupa kwa mucous nembanemba,
• nseru
• kupweteka m'mimba
• yafupika libido
• myalgia
• kuchepa magazi
• kutuluka thukuta kwambiri
• zotupa pakhungu,
• kuyabwa
• urticaria.

Koma nthawi zina pamakhala kufunika kuletsa mankhwalawo. Chifukwa chake, kupezeka kwawo kuyenera kudziwitsidwa kwa asing'anga.

Migwirizano ndi magwiritsidwe akusungidwa

Kuti izi zitheke, kuyatsidwa ndi dzuwa ndizovulaza, chifukwa chake ndikulimbikitsidwa kuyiyika pamalo amdima. Ndikothekanso kupeza madzi pamenepo - izi zimakhudza kusasinthika ndi mankhwala. Kutentha kosungirako komwe mumakonda kuli mpaka madigiri 30. Ndikofunikira kuti mankhwalawa athe kufalikira kwa ana.

Lorista imatha kugwiritsidwa ntchito zaka 5 (ngati malo osungirako anali oyenera). Pambuyo pa izi, mankhwalawo amaletsedwa.

Momwemonso

Pali mankhwala ambiri omwe amatha kusintha mankhwalawa. Izi zikuphatikiza:

Dokotala amayenera kusankha zomwe zikuyenerana ndi wodwalayo. Njira iliyonse yomwe yatchulidwa ili ndi mawonekedwe ake, chifukwa yomwe imatha kuvulaza.

Malingaliro odwala

Malinga ndi ndemanga za ogwiritsa ntchito, mutha kumvetsetsa zomwe zingachitike pa mankhwala a Lorista.

Kupsinjika kwanga kunayamba kukwera posachedwa, ndipo Lorista ndiye mankhwala oyamba omwe adokotala adandiuza. Pakadali pano, sindinganene chilichonse chokhudza iye. Poyamba panali kupweteka kwa mutu, koma adotolo adati thupi ili limayankha. Kenako zonse zidapita, ndipo ndidayamba kumva bwino. Kupsinjika kunachepera pafupifupi, ndipo kumangokhala wotopa ndi kugona kunasokeranso.

Valentina, wazaka 43

Ndinali ndimavuto opsinjika zaka zingapo zapitazo, choncho ndidakwanitsa kusintha mitundu ingapo ya antihypertensive mankhwala. Lorista ndi mankhwala abwino. Ndinalibe zovuta chifukwa chake. Zilibe mphamvu komanso zimachepetsa kupanikizika pang'onopang'ono, zomwe ndimazikonda kwambiri. Kulumphira mwadzidzidzi kuthamanga kwa magazi ndi kowopsa, ndipo ndikamachepetsa kwambiri mavuto, ndimamvanso zowawa. Chifukwa chake, kwa iwo omwe akungopanga matenda oopsa, mapiritsi awa atha kukhala othandiza. Koma ndi vuto la matenda oopsa, sangathandize - mankhwala amphamvu kwambiri omwe amachitika mwachangu akufunika pano.

Ekaterina, emyaka 46

Sindili ndi lingaliro labwino kwambiri za mankhwalawa. Ndinagwiritsa ntchito chida china nthawi zonse, ndipo zidandithandiza. Koma ndayiwala kugula mapiritsi, ndipo ndimayenera kugwiritsa ntchito mankhwala a mkazi wanga. Mankhwalawa adadzakhala a Lorista. Adatenga masiku angapo, zonse zili bwino, kenako kupanikizika kudayamba kukwera. Ndimaganiza kuti ndayiwala kumwa mankhwalawo ndikumwa piritsi lina. Zinkangokulirakulira. Kupsinjika kunachepa pang'ono, koma mutu wanga udayamba kupweteka, ndipo nseru ndi chizungulire zidawonekera. Zonsezi zidatha ndikuyimbira foni dokotala. Ndipo amandidzudzulanso, akunena kuti mankhwalawa sanali oyenera kwa ine. Mwina akulondola.

Victor, wazaka 49

Maganizo a odwala pankhani yothetsera vutoli nthawi zambiri amakhala abwino. Malingaliro olakwika nthawi zambiri amasiyidwa ndi anthu omwe adzipanga okha mankhwala.

Mu matenda a kwamikodzo, mankhwala a antihypertensive nthawi zina amagwiritsidwa ntchito, omwe amaphatikizapo Lorista. Mapiritsiwa amachotsa chinyezi chambiri m'thupi, chifukwa chake ndi chothandiza potupa chifukwa cha vuto la impso.

Koma zina mwazomwe zimachitika mu kwamikodzo ndiyo kuphwanya kwawo ntchito. Ndikofunikira kuphunzira mosamala malangizo ndikutsatira.